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Frédérique FAVIER

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After a PhD in protein crystallography in Strasbourg in the laboratory of D. Moras, I was recruited in 1995 as an assistant professor at the University of Nancy, now University of Lorraine, France. I carry out my research work in the BioMod team at the CRM2 (UMR CNRS-UL 7036). I am currently involved in two main research projects. - The first one concerns glutathione transferases. Although the first structures were established about thirty years ago, the diversity of these proteins throughout living organisms reveals roles that are complex and still poorly known, particularly in plants and fungi. In collaboration with the team of Pr. E. Gelhaye (IAM laboratory, Nancy), we have more than 10 years of experience in the analysis of the structure of these proteins, especially in complex with specialized metabolites, in relation with their function. - My second research area concerns horizontal gene transfer via integrative and conjugative elements (ICE) in Streptococcus thermophilus, a Gram-positive bacterium. We analyze the structures of proteins involved in the early stage of conjugation and in the transfer through the type IV secretion system, in collaboration with Drs N. Soler and B. Douzi in the ICE-TeA team led by Pr. N. Leblond-Bourget (DynAMic laboratory in Nancy) who are long-time specialists in the field. - Previously, I worked for a long time on methionine sulfoxide reductases, which are protective proteins against oxidative stress.


Structural insights into the interactions of glutathione transferases with a nitric oxide carrier and sodium nitroprusside

Mathieu Schwartz , Thomas Perrot , Jordan Beurton , Flavien Zannini , Mélanie Morel-Rouhier
Biochemical and Biophysical Research Communications, 2023, 649, pp.79-86. ⟨10.1016/j.bbrc.2023.01.099⟩
Journal articles hal-03985658v1
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New crystal form of human neuropilin-1 b1 fragment with six electrostatic mutations complexed with KDKPPR peptide ligand

Ibrahima Goudiaby , Thérèse E Malliavin , Eva Mocchetti , Sandrine Mathiot , Samir Acherar
Molecules, 2023, 28 (14), pp.5603. ⟨10.3390/molecules28145603⟩
Journal articles hal-04173135v1
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Biochemical and Structural Insights on the Poplar Tau Glutathione Transferase GSTU19 and 20 Paralogs Binding Flavonoids

Elodie Sylvestre-Gonon , Laura Morette , Morgane Viloria , Sandrine Mathiot , Alexis Boutilliat
Frontiers in Molecular Biosciences, 2022, 9, ⟨10.3389/fmolb.2022.958586⟩
Journal articles hal-03953075v1
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Structural and Biochemical Analysis of OrfG: The VirB8-like Component of the Conjugative Type IV Secretion System of ICESt3 From Streptococcus thermophilus

Julien Cappele , Abbas Mohamad Ali , Nathalie N. Leblond-Bourget , Sandrine Mathiot , Tiphaine Dhalleine
Frontiers in Molecular Biosciences, 2021, 8, ⟨10.3389/fmolb.2021.642606⟩
Journal articles hal-03196531v1
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A rush to explore protein–ligand electrostatic interaction energy with Charger

Vedran Vuković , Theo Leduc , Zoe Jelić-Matošević , Claude Didierjean , Frédérique Favier
Acta crystallographica Section D : Structural biology [1993-..], 2021, 77 (10), pp.1292-1304. ⟨10.1107/S2059798321008433⟩
Journal articles hal-03361937v1
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Diversity of Omega Glutathione Transferases in mushroom-forming fungi revealed by phylogenetic, transcriptomic, biochemical and structural approaches

Thomas Perrot , Mathieu Schwartz , Aurélie Deroy , Jean-Michel Girardet , Annegret Kohler
Fungal Genetics and Biology, 2021, 148, pp.103506. ⟨10.1016/j.fgb.2020.103506⟩
Journal articles hal-03143927v1

The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl-phenethylthiocarbamate reveals plasticity of its active site

Mathieu Schwartz , Thomas Perrot , Melanie Morel-Rouhier , Guillermo Mulliert , Éric Gelhaye
Protein Science, 2019, 28 (6), pp.1143-1150. ⟨10.1002/pro.3620⟩
Journal articles hal-02311418v1

Fungal Glutathione Transferases as Tools to Explore the Chemical Diversity of Amazonian Wood Extractives

Thomas Perrot , Mathieu Schwartz , Fanny Saiag , Guillaume Salzet , Stéphane Dumarcay
ACS Sustainable Chemistry & Engineering, 2018, 6 (10), pp.13078-13085. ⟨10.1021/acssuschemeng.8b02636⟩
Journal articles hal-02492224v1
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Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Emmanuel Aubert , Stéphane Dumarçay , Frédérique Favier
Scientific Reports, 2018, 8 (1), pp.8472. ⟨10.1038/s41598-018-26601-3⟩
Journal articles hal-01843732v1
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Trametes versicolor glutathione transferase Xi 3, a dual Cys-GST with catalytic specificities of both Xi and Omega classes

Mathieu Schwartz , Thomas Perrot , Aurélie Deroy , Thomas Roret , Melanie Morel-Rouhier
FEBS Letters, 2018, 592 (18), pp.3163-3172. ⟨10.1002/1873-3468.13224⟩
Journal articles hal-01959634v1
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Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones

Mathieu Schwartz , Claude Didierjean , Arnaud Hecker , Jean-Michel Girardet , Mélanie Morel-Rouhier
PLoS ONE, 2016, 11 (10), pp.e0164678. ⟨10.1371/journal.pone.0164678⟩
Journal articles hal-01539425v1

Introduction to Protein Science. Architecture, Function and Genomics. Third Edition. By Arthur M. Lesk. Oxford University Press, 2016. Pp. 466. Paperback. Price GBP 39.99. ISBN 9780198716846.

Claude Didierjean , Frédérique Tête-Favier
Acta crystallographica Section D : Structural biology [1993-..], 2016, 72 (12), pp.1308-1309. ⟨10.1107/S2059798316018283⟩
Journal articles hal-04483014v1

Structural view of fungal glutathionyl-hydroquinone reductases

Claude Didierjean , Mathieu Schwartz , Thomas Perrot , Arnaud Hecker , Éric Gelhaye
Acta Crystallographica Section A : Foundations and Advances [2014-..], 2016, 72 (a1), pp.s226 - s226. ⟨10.1107/S205327331609656X⟩
Journal articles hal-01549101v1

Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi

Thomas Roret , Anne Thuiier , Frederique Favier , Éric Gelhaye , Claude Didierjean
Fungal Genetics and Biology, 2015, 83, pp.103-112. ⟨10.1016/j.fgb.2015.09.002⟩
Journal articles hal-01521792v1
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Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

Pierre-Alexandre Lallement , Edgar Meux , José M. Gualberto , Stéphane Dumarcay , Frédérique Favier
FEBS Letters, 2015, 589 (1), pp.37 - 44. ⟨10.1016/j.febslet.2014.11.021⟩
Journal articles hal-01522015v1

Atypical features of a Ure2p glutathione transferase from Phanerochaete chrysosporium

Anne Thuillier , Thomas Roret , Frederique Favier , Éric Gelhaye , Jean-Pierre Jacquot
FEBS Letters, 2013, 587 (14), pp.2125 - 2130. ⟨10.1016/j.febslet.2013.05.031⟩
Journal articles hal-01268064v1
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Diversification of Fungal Specific Class A Glutathione Transferases in Saprotrophic Fungi

Yann Mathieu , Pascalita Prosper , Frederique Favier , Luc Harvengt , Claude Didierjean
PLoS ONE, 2013, 8 (11), ⟨10.1371/journal.pone.0080298⟩
Journal articles hal-01520994v1
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Characterization of a Phanerochaete chrysosporium Glutathione Transferase Reveals a Novel Structural and Functional Class with Ligandin Properties

Yann Mathieu , Pascalita Prosper , Marc Buée , Stephane Dumarcay , Frederique Favier
Journal of Biological Chemistry, 2012, 287 (46), pp.39001 - 39011. ⟨10.1074/jbc.M112.402776⟩
Journal articles hal-01268261v1

Sphingobium sp SYK-6 LigG involved in lignin degradation is structurally and biochemically related to the glutathione transferase omega class

Edgar Meux , Pascalita Prosper , Eiji Masai , Guillermo Mulliert , Stephane Dumarcay
FEBS Letters, 2012, 586 (22), pp.3944 - 3950. ⟨10.1016/j.febslet.2012.09.036⟩
Journal articles hal-01268258v1

Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin

Aik-Hong Teh , Jennifer Saito , Aida Baharuddin , Jason Tuckerman , James Newhouse
FEBS Letters, 2011, 585 (20), pp.3250-3258. ⟨10.1016/j.febslet.2011.09.002⟩
Journal articles hal-03576187v1
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Glutathione transferases of Phanerochaete chrysosporium S-glutathionyl-p-hydroquinone reductase belongs to a new structural class

Edgar Meux , Pascalita Prosper , Andrew Ngadin , Claude Didierjean , Mélanie Morel
Journal of Biological Chemistry, 2011, 286 (11), pp.9162-9173. ⟨10.1074/jbc.M110.194548⟩
Journal articles hal-02648116v1

Methionine Sulfoxide Reductase B Displays a High Level of Flexibility

Fanomezana Ranaivoson , Fabrice Neiers , Brice Kauffmann , Sandrine Boschi-Muller , Guy Branlant
Journal of Molecular Biology, 2009, 394 (1), pp.83 - 93. ⟨10.1016/j.jmb.2009.08.073⟩
Journal articles hal-01690443v1

A Structural Analysis of the Catalytic Mechanism of Methionine Sulfoxide Reductase A from Neisseria meningitidis

Fanomezana Ranaivoson , Mathias Antoine , Brice Kauffmann , Sandrine Boschi-Muller , André Aubry
Journal of Molecular Biology, 2008, 377 (1), pp.268 - 280. ⟨10.1016/j.jmb.2008.01.021⟩
Journal articles hal-01690635v1
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Functional and structural aspects of poplar cytosolic and plastidial type A methionine sulfoxide reductases

Nicolas Rouhier , Brice Kauffmann , Frédérique Tete-Favier , Pasquale Palladino , Pierre Gans
Journal of Biological Chemistry, 2007, 282 (5), pp.3367-3378. ⟨10.1074/jbc.M605007200⟩
Journal articles hal-02655515v1

Redox based anti-oxidant systems in plants: Biochemical and structural analyses

Nicolas Rouhier , Cha San Koh , Éric Gelhaye , Catherine Corbier , Frederique Favier
Biochimica et Biophysica Acta (BBA) - General Subjects, 2007, 1780 (11), pp.1249-1260. ⟨10.1016/j.bbagen.2007.12.007⟩
Journal articles hal-02662632v1

The X-ray structure of the N-terminal domaine of PILB from Neissera meningitidis reveals a thioredoxin-fold

F.M. Ranaivoson , B. Kauffmann , F. Neiers , J. Wu , S. Boschi-Muller
Journal of Molecular Biology, 2006, 358/2, pp.443-454
Journal articles hal-00089617v1

The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions. Review

B. Kauffmann , A. Aubry , F. Favier
BBA - Biochimica et Biophysica Acta, 2005, 1703 (Proteins & Proteomics), pp.249-260. ⟨10.1016/j.bbapap.2004.09.008⟩
Journal articles hal-00022899v1
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Crystal Structure of Two Ternary Complexes of Phosphorylating Glyceraldehyde-3-phosphate Dehydrogenase from Bacillus stearothermophilus with NAD and d-Glyceraldehyde 3-Phosphate

Claude Didierjean , Catherine Corbier , Mustapha Fatih , Frederique Favier , Sandrine Boschi-Muller
Journal of Biological Chemistry, 2003, 278 (15), pp.12968-12976. ⟨10.1074/jbc.M211040200⟩
Journal articles hal-01690824v1

Disulphide dimerised peptide creates a crystal contact in an anti-peptide antibody

Enrico Stura , Frédérique Tête-Favier , Sylviane Muller , André Aubry
Acta crystallographica Section D : Structural biology [1993-..], 2002, 58 (10), pp.1740-1743. ⟨10.1107/s0907444902012878⟩
Journal articles hal-03576166v1

Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase B domain of Neisseria meningitidis PILB

Brice Kauffmann , Frederique Favier , Alexandre Olry , Sandrine Boschi-Muller , Philippe Carpentier
Acta crystallographica Section D : Structural biology [1993-..], 2002, 58 (9), pp.1467 - 1469. ⟨10.1107/S0907444902010570⟩
Journal articles hal-01690844v1

Chemical mechanism and substrate binding sites of NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

S. Marchal , D. Cobessi , S. Rahuel-Clermont , F. Tête-Favier , A. Aubry
Chemico-Biological Interactions, 2001, 130-132 (1-3), pp.15-28
Journal articles hal-00151129v1

Crystal structure of the Escherichia coli peptide methionine sulphoxide reductase at 1.9 A resolution.

F. Tête-Favier , D. Cobessi , S. Boschi-Muller , S. Azza , G. Branlant
Structure / Struct Fold Des; Structure (Camb ), 2000, 8 (11), pp.1167-78
Journal articles hal-00151127v1

Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase from Escherichia coli.

F. Tête-Favier , D. Cobessi , G. A. Leonard , S. Azza , F. Talfournier
Acta crystallographica Section D : Structural biology [1993-..], 2000, 56 (Pt 9), pp.1194-7. ⟨10.1107/s0907444903006814⟩
Journal articles hal-00151126v1

Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

D. Cobessi , F. Tête-Favier , S. Marchal , G. Branlant , A. Aubry
Journal of Molecular Biology, 2000, 300 (1), pp.141-52. ⟨10.1006/jmbi.2000.3824⟩
Journal articles hal-00151125v1

Apo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

D. Cobessi , F. Tête-Favier , S. Marchal , S. Azza , G. Branlant
Journal of Molecular Biology, 1999, 290 (1), pp.161-73. ⟨10.1006/jmbi.1999.2853⟩
Journal articles hal-00151107v1

A ‘specificity’ pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil

A Urzhumtsev , F. Tête-Favier , A Mitschler , J Barbanton , P Barth
Structure, 1997, 5 (5), pp.601-612. ⟨10.1016/s0969-2126(97)00216-5⟩
Journal articles hal-03576110v1

Structure determination of aldose reductase: joys and traps of local symmetry averaging

F. Tête-Favier , J. Rondeau , A. Podjarny , D. Moras
Acta crystallographica Section D : Structural biology [1993-..], 1993, 49 (2), pp.246-256. ⟨10.1107/s090744499200773x⟩
Journal articles hal-03576093v1

Novel NADPH-binding domain revealed by the crystal structure of aldose reductase

J.-M. Rondeau , F. Tête-Favier , A Podjarny , J.-M. Reymann , P. Barth
Nature, 1992, 355 (6359), pp.469-472. ⟨10.1038/355469a0⟩
Journal articles hal-03576054v1

Structure of a VirB8-like protein, one of the main components of the Type IV secretion system involved in horizontal gene transfer between bacteria

Julien Cappele , Badreddine Douzi , Abbas Mohamad Ali , Nathalie Leblond-Bourget , Sandrine Mathiot
SFB-GEM Meeting 2021 - Biophysics of membranes and beyond., Sep 2021, Online, France
Conference papers hal-03576846v1

Interactions between wood polyphenols and detoxification enzymes of the white rot Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Emmanuel Aubert , Stephane Dumarcay , Frederique Favier
49th IRGWP Annual Meeting, Apr 2018, Johannesburg, South Africa. pp.IRG/WP 18-10906
Conference papers hal-03127877v1

Glutathione Transferase Xi: Structural insights into a class of enzymes conserved in fungi

Mathieu Schwartz , Aurélie Deroy , Éric Gelhaye , Arnaud Hecker , Frédérique Favier
3rd Transnational Redox Symposium, 2017, Vandoeuvre -les-Nancy, France
Conference papers hal-04482713v1

Etude cristallographique de la glutathion-s-transferase omega1 de phanerochaete chrysosporium

Pascalita Prosper , Edgar Meux , Éric Gelhaye , Claude Didierjean , Frederique Favier
AFC 2010, Jul 2010, Strasbourg, France
Conference papers hal-04482604v1

Structure tridimensionnelle d'une méthionine sulfoxyde reductase de classe A en complexe avec un substrat

F.M. Ranaivoson , M. Antoine , S. Boschi-Muller , G. Branlant , A. Aubry
14ème Réunion du Groupe Français des Peptides et des Protéines (GFPP), 2005, Aussois, France
Conference papers hal-00089642v1

The X-ray structure of the N-terminal domain of pilb from Neisseria meningitidis reveals a thioredoxin-fold

F.M. Ranaivoson , F. Favier , C. Didierjean
Regio Meeting, 2005, La Bresse, France
Conference papers hal-00089656v1

Crystallographic and biochemical study of glutathione transferase Omega 3S from Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Frédérique Favier , Stéphane Dumarcay , Éric Gelhaye
2. FesBioNet Training School, Sep 2018, Grenoble, France
Conference poster hal-04482878v1

Structural evidences of flavonoid-binding glutathione transferases in Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Stéphane Dumarçay , Melanie Morel-Rouhier , Éric Gelhaye
50th International School of Crystallography, Integrative Structural Biology, Jun 2017, Erice (Sicile), France
Conference poster hal-04482882v1
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Structural view of fungal glutathionyl-hydroquinone reductases

C. Didierjean , Mathieu Schwartz , Thomas Perrot , Arnaud Hecker , Éric Gelhaye
30. European Crystallographic Meeting, Aug 2016, Basel, Switzerland. Wiley-Blackwell, Acta crystallographica. Section A, Foundations of crystallography, A72, 1 p., 2016, ⟨10.1107/S205327331609656X⟩
Conference poster hal-02743022v1

Crystallographic Study of a Xi-class Glutathione Transferase from Trametes versicolor

Mathieu Schwartz , Aurélie Deroy , Éric Gelhaye , Claude Didierjean , Frédérique Favier
2nd redox meeting, May 2015, Vandoeuvre lès Nancy, France
Conference poster hal-04482699v1

Caractérisations biochimique et structurale des glutathion transférases du basidiomycète Phanerochaete chrysosporium

Claude Didierjean , Pascalita Prosper , Thomas Roret , Melanie Morel-Rouhier , Éric Gelhaye
Congrès de l'AFC, Jul 2013, Bordeaux, France
Conference poster hal-04482655v1

Structurefunction relationships study of the glutathione-S-transferase superfamily in the saprophytic fungus Phanerochaete chrysosporium

Pascalita Prosper , Edgar Meux , Mélanie Morel , Éric Gelhaye , Claude Didierjean
ACA Meeting, May 2011, New Orleans, United States
Conference poster hal-04482617v1