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Frédérique FAVIER

37
Documents
Researcher identifiers

Presentation

After a PhD in protein crystallography in Strasbourg in the laboratory of D. Moras, I was recruited in 1995 as an assistant professor at the University of Nancy, now University of Lorraine, France. I carry out my research work in the BioMod team at the CRM2 (UMR CNRS-UL 7036). I am currently involved in two main research projects. - The first one concerns glutathione transferases. Although the first structures were established about thirty years ago, the diversity of these proteins throughout living organisms reveals roles that are complex and still poorly known, particularly in plants and fungi. In collaboration with the team of Pr. E. Gelhaye (IAM laboratory, Nancy), we have more than 10 years of experience in the analysis of the structure of these proteins, especially in complex with specialized metabolites, in relation with their function. - My second research area concerns horizontal gene transfer via integrative and conjugative elements (ICE) in Streptococcus thermophilus, a Gram-positive bacterium. We analyze the structures of proteins involved in the early stage of conjugation and in the transfer through the type IV secretion system, in collaboration with Drs N. Soler and B. Douzi in the ICE-TeA team led by Pr. N. Leblond-Bourget (DynAMic laboratory in Nancy) who are long-time specialists in the field. - Previously, I worked for a long time on methionine sulfoxide reductases, which are protective proteins against oxidative stress.

Publications

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Biochemical and Structural Insights on the Poplar Tau Glutathione Transferase GSTU19 and 20 Paralogs Binding Flavonoids

Elodie Sylvestre-Gonon , Laura Morette , Morgane Viloria , Sandrine Mathiot , Alexis Boutilliat et al.
Frontiers in Molecular Biosciences, 2022, 9, ⟨10.3389/fmolb.2022.958586⟩
Journal articles hal-03953075v1
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Diversity of Omega Glutathione Transferases in mushroom-forming fungi revealed by phylogenetic, transcriptomic, biochemical and structural approaches

Thomas Perrot , Mathieu Schwartz , Aurélie Deroy , Jean-Michel Girardet , Annegret Kohler et al.
Fungal Genetics and Biology, 2021, 148, pp.103506. ⟨10.1016/j.fgb.2020.103506⟩
Journal articles hal-03143927v1
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A rush to explore protein–ligand electrostatic interaction energy with Charger

Vedran Vuković , Theo Leduc , Zoe Jelić-Matošević , Claude Didierjean , Frédérique Favier et al.
Acta crystallographica Section D : Structural biology [1993-..], 2021, 77 (10), pp.1292-1304. ⟨10.1107/S2059798321008433⟩
Journal articles hal-03361937v1
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Structural and Biochemical Analysis of OrfG: The VirB8-like Component of the Conjugative Type IV Secretion System of ICESt3 From Streptococcus thermophilus

Julien Cappele , Abbas Mohamad Ali , Nathalie N. Leblond-Bourget , Sandrine Mathiot , Tiphaine Dhalleine et al.
Frontiers in Molecular Biosciences, 2021, 8, ⟨10.3389/fmolb.2021.642606⟩
Journal articles hal-03196531v1

The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl-phenethylthiocarbamate reveals plasticity of its active site

Mathieu Schwartz , Thomas Perrot , Melanie Morel-Rouhier , Guillermo Mulliert , Éric Gelhaye et al.
Protein Science, 2019, 28 (6), pp.1143-1150. ⟨10.1002/pro.3620⟩
Journal articles hal-02311418v1
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Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor

Mathieu Schwartz , Thomas Perrot , Emmanuel Aubert , Stéphane Dumarçay , Frédérique Favier et al.
Scientific Reports, 2018, 8 (1), pp.8472. ⟨10.1038/s41598-018-26601-3⟩
Journal articles hal-01843732v1

Fungal Glutathione Transferases as Tools to Explore the Chemical Diversity of Amazonian Wood Extractives

Thomas Perrot , Mathieu Schwartz , Fanny Saiag , Guillaume Salzet , Stéphane Dumarcay et al.
ACS Sustainable Chemistry & Engineering, 2018, 6 (10), pp.13078-13085. ⟨10.1021/acssuschemeng.8b02636⟩
Journal articles hal-02492224v1
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Trametes versicolor glutathione transferase Xi 3, a dual Cys-GST with catalytic specificities of both Xi and Omega classes

Mathieu Schwartz , Thomas Perrot , Aurélie Deroy , Thomas Roret , Melanie Morel-Rouhier et al.
FEBS Letters, 2018, 592 (18), pp.3163-3172. ⟨10.1002/1873-3468.13224⟩
Journal articles hal-01959634v1

Structural view of fungal glutathionyl-hydroquinone reductases

Claude Didierjean , Mathieu Schwartz , Thomas Perrot , Arnaud Hecker , Éric Gelhaye et al.
Acta Crystallographica Section A : Foundations and Advances [2014-..], 2016, 72 (a1), pp.s226 - s226. ⟨10.1107/S205327331609656X⟩
Journal articles hal-01549101v1
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Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones

Mathieu Schwartz , Claude Didierjean , Arnaud Hecker , Jean-Michel Girardet , Mélanie Morel-Rouhier et al.
PLoS ONE, 2016, 11 (10), pp.e0164678. ⟨10.1371/journal.pone.0164678⟩
Journal articles hal-01539425v1

Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi

Thomas Roret , Anne Thuiier , Frederique Favier , Éric Gelhaye , Claude Didierjean et al.
Fungal Genetics and Biology, 2015, 83, pp.103-112. ⟨10.1016/j.fgb.2015.09.002⟩
Journal articles hal-01521792v1
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Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

Pierre-Alexandre Lallement , Edgar Meux , José M. Gualberto , Stéphane Dumarcay , Frédérique Favier et al.
FEBS Letters, 2015, 589 (1), pp.37 - 44. ⟨10.1016/j.febslet.2014.11.021⟩
Journal articles hal-01522015v1

Atypical features of a Ure2p glutathione transferase from Phanerochaete chrysosporium

Anne Thuillier , Thomas Roret , Frederique Favier , Éric Gelhaye , Jean-Pierre Jacquot et al.
FEBS Letters, 2013, 587 (14), pp.2125 - 2130. ⟨10.1016/j.febslet.2013.05.031⟩
Journal articles hal-01268064v1
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Diversification of Fungal Specific Class A Glutathione Transferases in Saprotrophic Fungi

Yann Mathieu , Pascalita Prosper , Frederique Favier , Luc Harvengt , Claude Didierjean et al.
PLoS ONE, 2013, 8 (11), ⟨10.1371/journal.pone.0080298⟩
Journal articles hal-01520994v1
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Characterization of a Phanerochaete chrysosporium Glutathione Transferase Reveals a Novel Structural and Functional Class with Ligandin Properties

Yann Mathieu , Pascalita Prosper , Marc Buee , Stephane Dumarcay , Frederique Favier et al.
Journal of Biological Chemistry, 2012, 287 (46), pp.39001 - 39011. ⟨10.1074/jbc.M112.402776⟩
Journal articles hal-01268261v1

Sphingobium sp SYK-6 LigG involved in lignin degradation is structurally and biochemically related to the glutathione transferase omega class

Edgar Meux , Pascalita Prosper , Eiji Masai , Guillermo Mulliert , Stephane Dumarcay et al.
FEBS Letters, 2012, 586 (22), pp.3944 - 3950. ⟨10.1016/j.febslet.2012.09.036⟩
Journal articles hal-01268258v1

Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin

Aik-Hong Teh , Jennifer Saito , Aida Baharuddin , Jason Tuckerman , James Newhouse et al.
FEBS Letters, 2011, 585 (20), pp.3250-3258. ⟨10.1016/j.febslet.2011.09.002⟩
Journal articles hal-03576187v1
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Glutathione transferases of Phanerochaete chrysosporium S-glutathionyl-p-hydroquinone reductase belongs to a new structural class

Edgar Meux , Pascalita Prosper , Andrew Ngadin , Claude Didierjean , Mélanie Morel et al.
Journal of Biological Chemistry, 2011, 286 (11), pp.9162-9173. ⟨10.1074/jbc.M110.194548⟩
Journal articles hal-02648116v1

Methionine Sulfoxide Reductase B Displays a High Level of Flexibility

Fanomezana Ranaivoson , Fabrice Neiers , Brice Kauffmann , Sandrine Boschi-Muller , Guy Branlant et al.
Journal of Molecular Biology, 2009, 394 (1), pp.83 - 93. ⟨10.1016/j.jmb.2009.08.073⟩
Journal articles hal-01690443v1

A Structural Analysis of the Catalytic Mechanism of Methionine Sulfoxide Reductase A from Neisseria meningitidis

Fanomezana Ranaivoson , Mathias Antoine , Brice Kauffmann , Sandrine Boschi-Muller , André Aubry et al.
Journal of Molecular Biology, 2008, 377 (1), pp.268 - 280. ⟨10.1016/j.jmb.2008.01.021⟩
Journal articles hal-01690635v1
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Functional and structural aspects of poplar cytosolic and plastidial type A methionine sulfoxide reductases

Nicolas Rouhier , Brice Kauffmann , Frédérique Tete-Favier , Pasquale Palladino , Pierre Gans et al.
Journal of Biological Chemistry, 2007, 282 (5), pp.3367-3378. ⟨10.1074/jbc.M605007200⟩
Journal articles hal-02655515v1

Redox based anti-oxidant systems in plants: Biochemical and structural analyses

Nicolas Rouhier , Cha San Koh , Éric Gelhaye , Catherine Corbier , Frederique Favier et al.
Biochimica et Biophysica Acta (BBA) - General Subjects, 2007, 1780 (11), pp.1249-1260. ⟨10.1016/j.bbagen.2007.12.007⟩
Journal articles hal-02662632v1

The X-ray structure of the N-terminal domaine of PILB from Neissera meningitidis reveals a thioredoxin-fold

F.M. Ranaivoson , B. Kauffmann , F. Neiers , J. Wu , S. Boschi-Muller et al.
Journal of Molecular Biology, 2006, 358/2, pp.443-454
Journal articles hal-00089617v1

The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions. Review

B. Kauffmann , A. Aubry , F. Favier
BBA - Biochimica et Biophysica Acta, 2005, 1703 (Proteins & Proteomics), pp.249-260. ⟨10.1016/j.bbapap.2004.09.008⟩
Journal articles hal-00022899v1
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Crystal Structure of Two Ternary Complexes of Phosphorylating Glyceraldehyde-3-phosphate Dehydrogenase from Bacillus stearothermophilus with NAD and d-Glyceraldehyde 3-Phosphate

Claude Didierjean , Catherine Corbier , Mustapha Fatih , Frederique Favier , Sandrine Boschi-Muller et al.
Journal of Biological Chemistry, 2003, 278 (15), pp.12968-12976. ⟨10.1074/jbc.M211040200⟩
Journal articles hal-01690824v1

Disulphide dimerised peptide creates a crystal contact in an anti-peptide antibody

Enrico Stura , Frédérique Tête-Favier , Sylviane Muller , André Aubry
Acta crystallographica Section D : Structural biology [1993-..], 2002, 58 (10), pp.1740-1743. ⟨10.1107/s0907444902012878⟩
Journal articles hal-03576166v1

Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase B domain of Neisseria meningitidis PILB

Brice Kauffmann , Frederique Favier , Alexandre Olry , Sandrine Boschi-Muller , Philippe Carpentier et al.
Acta crystallographica Section D : Structural biology [1993-..], 2002, 58 (9), pp.1467 - 1469. ⟨10.1107/S0907444902010570⟩
Journal articles hal-01690844v1

Chemical mechanism and substrate binding sites of NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

S. Marchal , D. Cobessi , S. Rahuel-Clermont , F. Tête-Favier , A. Aubry et al.
Chemico-Biological Interactions, 2001, 130-132 (1-3), pp.15-28
Journal articles hal-00151129v1

Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

D. Cobessi , F. Tête-Favier , S. Marchal , G. Branlant , A. Aubry et al.
Journal of Molecular Biology, 2000, 300 (1), pp.141-52. ⟨10.1006/jmbi.2000.3824⟩
Journal articles hal-00151125v1

Crystallization and preliminary X-ray diffraction studies of the peptide methionine sulfoxide reductase from Escherichia coli.

F. Tête-Favier , D. Cobessi , G. A. Leonard , S. Azza , F. Talfournier et al.
Acta crystallographica Section D : Structural biology [1993-..], 2000, 56 (Pt 9), pp.1194-7. ⟨10.1107/s0907444903006814⟩
Journal articles hal-00151126v1

Crystal structure of the Escherichia coli peptide methionine sulphoxide reductase at 1.9 A resolution.

F. Tête-Favier , D. Cobessi , S. Boschi-Muller , S. Azza , G. Branlant et al.
Structure / Struct Fold Des; Structure (Camb ), 2000, 8 (11), pp.1167-78
Journal articles hal-00151127v1

Apo and holo crystal structures of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

D. Cobessi , F. Tête-Favier , S. Marchal , S. Azza , G. Branlant et al.
Journal of Molecular Biology, 1999, 290 (1), pp.161-73. ⟨10.1006/jmbi.1999.2853⟩
Journal articles hal-00151107v1
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Structural view of fungal glutathionyl-hydroquinone reductases

C. Didierjean , Mathieu Schwartz , Thomas Perrot , Arnaud Hecker , Éric Gelhaye et al.
30. European Crystallographic Meeting, Aug 2016, Basel, Switzerland. Wiley-Blackwell, Acta crystallographica. Section A, Foundations of crystallography, A72, 1 p., 2016, ⟨10.1107/S205327331609656X⟩
Conference poster hal-02743022v1