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Frédérique FAVIER

6
Documents
Identifiants chercheurs

Présentation

After a PhD in protein crystallography in Strasbourg in the laboratory of D. Moras, I was recruited in 1995 as an assistant professor at the University of Nancy, now University of Lorraine, France. I carry out my research work in the BioMod team at the CRM2 (UMR CNRS-UL 7036). I am currently involved in two main research projects. - The first one concerns glutathione transferases. Although the first structures were established about thirty years ago, the diversity of these proteins throughout living organisms reveals roles that are complex and still poorly known, particularly in plants and fungi. In collaboration with the team of Pr. E. Gelhaye (IAM laboratory, Nancy), we have more than 10 years of experience in the analysis of the structure of these proteins, especially in complex with specialized metabolites, in relation with their function. - My second research area concerns horizontal gene transfer via integrative and conjugative elements (ICE) in Streptococcus thermophilus, a Gram-positive bacterium. We analyze the structures of proteins involved in the early stage of conjugation and in the transfer through the type IV secretion system, in collaboration with Drs N. Soler and B. Douzi in the ICE-TeA team led by Pr. N. Leblond-Bourget (DynAMic laboratory in Nancy) who are long-time specialists in the field. - Previously, I worked for a long time on methionine sulfoxide reductases, which are protective proteins against oxidative stress.

Publications

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Structural insights into the interactions of glutathione transferases with a nitric oxide carrier and sodium nitroprusside

Mathieu Schwartz , Thomas Perrot , Jordan Beurton , Flavien Zannini , Mélanie Morel-Rouhier
Biochemical and Biophysical Research Communications, 2023, 649, pp.79-86. ⟨10.1016/j.bbrc.2023.01.099⟩
Article dans une revue hal-03985658v1
Image document

Biochemical and Structural Insights on the Poplar Tau Glutathione Transferase GSTU19 and 20 Paralogs Binding Flavonoids

Elodie Sylvestre-Gonon , Laura Morette , Morgane Viloria , Sandrine Mathiot , Alexis Boutilliat
Frontiers in Molecular Biosciences, 2022, 9, ⟨10.3389/fmolb.2022.958586⟩
Article dans une revue hal-03953075v1
Image document

Diversity of Omega Glutathione Transferases in mushroom-forming fungi revealed by phylogenetic, transcriptomic, biochemical and structural approaches

Thomas Perrot , Mathieu Schwartz , Aurélie Deroy , Jean-Michel Girardet , Annegret Kohler
Fungal Genetics and Biology, 2021, 148, pp.103506. ⟨10.1016/j.fgb.2020.103506⟩
Article dans une revue hal-03143927v1
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Trametes versicolor glutathione transferase Xi 3, a dual Cys-GST with catalytic specificities of both Xi and Omega classes

Mathieu Schwartz , Thomas Perrot , Aurélie Deroy , Thomas Roret , Melanie Morel-Rouhier
FEBS Letters, 2018, 592 (18), pp.3163-3172. ⟨10.1002/1873-3468.13224⟩
Article dans une revue hal-01959634v1
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Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones

Mathieu Schwartz , Claude Didierjean , Arnaud Hecker , Jean-Michel Girardet , Mélanie Morel-Rouhier
PLoS ONE, 2016, 11 (10), pp.e0164678. ⟨10.1371/journal.pone.0164678⟩
Article dans une revue hal-01539425v1

Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi

Thomas Roret , Anne Thuiier , Frederique Favier , Éric Gelhaye , Claude Didierjean
Fungal Genetics and Biology, 2015, 83, pp.103-112. ⟨10.1016/j.fgb.2015.09.002⟩
Article dans une revue hal-01521792v1