Gérard Gradwohl

Directeur de Recherche Inserm (DR1), Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue laurent Fries, 67404 Illkirch, Eurométropole Strasbourg, France

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Researcher identifiers

gerard-gradwohl
0000-0002-6730-2615
IdRef : 101547390
ResearcherId : 1145323

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Research domains

Skills

Publications

	Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice Florence Blot , Justine Marchix , Miriam Ejarque , Sara Jimenez , Aline Meunier Cellular and Molecular Gastroenterology and Hepatology, 2023, ⟨10.1016/j.jcmgh.2023.02.013⟩ Journal articles hal-04007457v1
	Characterization of cell-fate decision landscapes by estimating transcription factor dynamics Sara Jiménez , Valérie Schreiber , Reuben Mercier , Gérard Gradwohl , Nacho Molina Cell Reports Methods, 2023, pp.100512. ⟨10.1016/j.crmeth.2023.100512⟩ Journal articles inserm-04140681v1
	Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine Hui Joyce Li , Subir Ray , Alper Kucukural , Gerard Gradwohl , Andrew Leiter Cellular and Molecular Gastroenterology and Hepatology, 2021, 11 (2), pp.433-448. ⟨10.1016/j.jcmgh.2020.08.006⟩ Journal articles inserm-03455700v1
	Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells Kaare V. Grunddal , Sarah Tonack , Kristoffer L. Egerod , Jonanthan James Thompson , Natalia Petersen Molecular metabolism, 2021, 51, ⟨10.1016/j.molmet.2021.101231⟩ Journal articles hal-03708073v1
	Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network Valérie Schreiber , Reuben Mercier , Sara Jiménez , Tao Ye , Emmanuel García-Sánchez Molecular metabolism, 2021, 53, pp.101313. ⟨10.1016/j.molmet.2021.101313⟩ Journal articles hal-03454968v1
	Ascl1 is required to specify a subset of ventromedial hypothalamic neurons Shaghayegh Aslanpour , Jessica M Rosin , Anjali Balakrishnan , Natalia Klenin , Florence Blot Development (Cambridge, England), 2020, 147 (10), pp.dev180067. ⟨10.1242/dev.180067⟩ Journal articles inserm-03229584v1
	Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production Julie Piccand , Constance Vagne , Florence Blot , Aline Meunier , Anthony Beucher Molecular metabolism, 2019, 29, pp.24-39. ⟨10.1016/j.molmet.2019.08.007⟩ Journal articles hal-02361214v1
	A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas Léon van Gurp , Mauro Muraro , Tim Dielen , Lina Seneby , Gitanjali Dharmadhikari Development (Cambridge, England), 2019, 146 (12), pp.dev173716. ⟨10.1242/dev.173716⟩ Journal articles inserm-02438309v1
	Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas Laure Nivlet , Joel Herrmann , Delia Esteban Martin , Aline Meunier , Christophe Orvain Journal of Molecular Endocrinology, 2016, 56 (2), pp.77-90. ⟨10.1530/JME-15-0213⟩ Journal articles inserm-03455716v1
	STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage S de Groef , D Renmans , Y Cai , G Leuckx , S Roels Cell Death and Disease, 2016, 7 (6), pp.e2272-e2272. ⟨10.1038/cddis.2016.171⟩ Journal articles inserm-03455713v1
	Pairing-up SOX to kick-start beta cell genesis Anne Grapin-Botton , Philip Allan Seymour , Gerard Gradwohl Diabetologia, 2015, 58 (5), pp.859-861. ⟨10.1007/s00125-015-3539-2⟩ Journal articles hal-04314988v1
	Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells Ramkumar Mohan , Yiping Mao , Shungang Zhang , Yu-Wei Zhang , Cheng-Ran Xu Journal of Biological Chemistry, 2015, 290 (32), pp.19955-19966. ⟨10.1074/jbc.M115.650705⟩ Journal articles hal-04004363v1
	Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells Julie Piccand , Perrine Strasser , David J. Hodson , Aline Meunier , Tao Ye Cell Reports, 2014, 9 (6), pp.2219-2232 Journal articles hal-04004335v1
	Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Julie Piccand , Aline Meunier , Carole Merle , Zhengping Jia , Jean-Vianney Barnier Diabetes, 2014, 63 (1), pp.203-15. ⟨10.2337/db13-0384⟩ Journal articles hal-01181234v1
	Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity Neal Anthwal , Michelle Pelling , Suzanne Claxton , Georg Mellitzer , Caitlin Collin Disease Models & Mechanisms, 2013, ⟨10.1242/dmm.011916⟩ Journal articles hal-04006946v1
	Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes. Keith Al-Hasani , Anja Pfeifer , Monica Courtney , Nouha Ben-Othman , Elisabet Gjernes Developmental Cell, 2013, epub ahead of print. ⟨10.1016/j.devcel.2013.05.018⟩ Journal articles hal-00843533v1
	The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice. Anthony Beucher , Elisabet Gjernes , Caitlin Collin , Monica Courtney , Aline Meunier PLoS ONE, 2012, 7 (5), pp.e36449. ⟨10.1371/journal.pone.0036449⟩ Journal articles hal-00760293v1
	Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development Anthony Beucher , Mercè Martin , Caroline Spenle , Martine Poulet , Caitlin Collin Developmental biology, 2012, 361 (2), pp.277-285. ⟨10.1016/j.ydbio.2011.10.025⟩ Journal articles hal-04210579v1
	Pancreatic islet and progenitor cell surface markers with cell sorting potential J Hald , T Galbo , C Rescan , L Radzikowski , A Sprinkel Diabetologia, 2012, 55 (1), pp.154-165. ⟨10.1007/s00125-011-2295-1⟩ Journal articles hal-04354737v1
	Enteroendocrine cells and lipid absorption Georges Mellitzer , Gerard Gradwohl Current Opinion in Lipidology, 2011, 22 (3), pp.171-175. ⟨10.1097/MOL.0b013e32834622a2⟩ Journal articles hal-04692450v1
	Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus Michelle Pelling , Neal Anthwal , David Mcnay , Gerard Gradwohl , Andrew Leiter Developmental Biology, 2011, 349 (2), pp.406-416. ⟨10.1016/j.ydbio.2010.11.007⟩ Journal articles hal-04006971v1
	Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development Josselin Soyer , Lydie Flasse , Wolfgang Raffelsberger , Anthony Beucher , Christophe Orvain Development: For advances in developmental biology and stem cells, 2010, 137 (2), pp.203-212. ⟨10.1242/dev.041673⟩ Journal articles hal-04088194v1
	Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival Georg Mellitzer , Anthony Beucher , Viviane Lobstein , Pascal Michel , Sylvie Robine Journal of Clinical Investigation, 2010, 120 (5), pp.1708-1721. ⟨10.1172/JCI40794⟩ Journal articles hal-04004280v1
	Expression of neuropeptide Y and agouti-related peptide in the hypothalamic arcuate nucleus of newborn neurogenin3 null mutant mice Yuta Arai , Gerard Gradwohl , Yoko Kameda Cell and Tissue Research, 2010, 340 (1), pp.137-145. ⟨10.1007/s00441-009-0925-4⟩ Journal articles hal-04040219v1
	Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Tatiana V Petrova , Antti Nykänen , Camilla Norrmén , Konstantin I Ivanov , Leif C Andersson Cancer Cell, 2008, 13 (5), pp.407-19. ⟨10.1016/j.ccr.2008.02.020⟩ Journal articles hal-00282904v1
	GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist Nayeem Quayum , Alecksandr Kutchma , Suparna A. Sarkar , Kirstine Juhl , Gerard Gradwohl Experimental Diabetes Research, 2008, 2008, ⟨10.1155/2008/312060⟩ Journal articles hal-04118007v1
	Characterization of the proneural gene regulatory network during mouse telencephalon development Julia M. Gohlke , Olivier Armant , Frederick M. Parham , Marjolein V. Smith , Celine Zimmer BMC Biology, 2008, 6, ⟨10.1186/1741-7007-6-15⟩ Journal articles hal-04098272v1
	In vitro models of intestinal epithelial cell differentiation Patricia Simon-Assmann , N. Turck , M. Sidhoum-Jenny , Gérard Gradwohl , Michèle Kedinger Cell Biology and Toxicology, 2007, 23 (4), pp.241-256. ⟨10.1007/s10565-006-0175-0⟩ Journal articles hal-04106090v1
	Transcription Factors in Pancreatic Development Merce Martin , Viviane Hauer , Mélanie Messmer , Christophe Orvain , Gérard Gradwohl Endocrine Development, 2007, pp.24-32. ⟨10.1159/000109602⟩ Journal articles hal-04117367v1
	Temporal Control of Neurogenin3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types Kerstin Johansson , Umut Dursun , Nathalie Jordan , Guoqiang Gu , Friedrich Beermann Developmental Cell, 2007, 12 (3), pp.457-465. ⟨10.1016/j.devcel.2007.02.010⟩ Journal articles hal-04006988v1
	Development of the endocrine pancreas Gérard Gradwohl Diabetes & Metabolism, 2006, 32 (5), pp.532-533. ⟨10.1016/S1262-3636(06)72807-5⟩ Journal articles hal-04093892v1
	Genetic determinants of pancreatic epsilon-cell development. R Scott Heller , Marjorie Jenny , Patrick Collombat , Ahmed Mansouri , Catherine Tomasetto Developmental Biology, 2005, 286 (1), pp.217-24. ⟨10.1016/j.ydbio.2005.06.041⟩ Journal articles hal-00187550v1
	Lack of TCF2/vHNF1 in mice leads to pancreas agenesis C. Haumaitre , E. Barbacci , M. Jenny , M. Ott , Gérard Gradwohl Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (5), pp.1490-1495. ⟨10.1073/pnas.0405776102⟩ Journal articles hal-04129661v1
	Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Mercè Martín , Jabier Gallego-Llamas , Vanessa Ribes , Michèle Kedinger , Karen Niederreither Developmental Biology, 2005, 284 (2), pp.399-411. ⟨10.1016/j.ydbio.2005.05.035⟩ Journal articles hal-00187679v1
	Transcriptional program of the endocrine pancreas in mice and humans Klaus H. Kaestner , Catherine S. Lee , L. Marie Scearce , John E. Brestelli , Athanasios Arsenlis Diabetes, 2003, 52 (7), pp.1604-1610. ⟨10.2337/diabetes.52.7.1604⟩ Journal articles hal-04143730v1
	Opposing actions of Arx and Pax4 in endocrine pancreas development Patrick Collombat , Ahmed Mansouri , Jacob Hecksher-Sorensen , Palle Serup , Jens Krull Genes and Development, 2003, 17 (20), pp.2591-2603. ⟨10.1101/gad.269003⟩ Journal articles hal-04138430v1
	Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium Marjorie Jenny , Céline Uhl , Colette Roche , Isabelle Duluc , Valérie Guillermin The EMBO Journal, 2002, 21 (23), pp.6338-6347. ⟨10.1093/emboj/cdf649⟩ Journal articles hal-03812784v1
	Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord Raffaella Scardigli , Carol Schuurmans , Gerard Gradwohl , François Guillemot Neuron, 2001, 31 (2), pp.203-217. ⟨10.1016/s0896-6273(01)00358-0⟩ Journal articles hal-04112682v1
	neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas Gérard Gradwohl , Andrée Dierich , Marianne Lemeur , François Guillemot Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (4), pp.1607-1611. ⟨10.1073/pnas.97.4.1607⟩ Journal articles hal-04006991v1
	Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3 Patrick Jacquemin , Serge M. Durviaux , Jan Jensen , Catherine Godfraind , Gerard Gradwohl Molecular and Cellular Biology, 2000, 20 (12), pp.4445-4454. ⟨10.1128/MCB.20.12.4445-4454.2000⟩ Journal articles hal-04128943v1
	Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation Toshiyuki Ohtsuka , Makoto Ishibashi , Gerard Gradwohl , Shigetada Nakanishi , François Guillemot EMBO Journal, 1999, 18 (8), pp.2196-2207. ⟨10.1093/emboj/18.8.2196⟩ Journal articles hal-04027634v1
	The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons Carol Fode , Gérard Gradwohl , Xavier Morin , Andrée Dierich , Marianne Lemeur Neuron, 1998, 20 (3), pp.483-494. ⟨10.1016/s0896-6273(00)80989-7⟩ Journal articles hal-04007011v1
	The activity of neurogenin1 is controlled by local cues in the zebrafish embryo P Blader , Natacha Schroeder , Gerard Gradwohl , F Guillemot , U Strähle Development (Cambridge, England), 1997, 124 (22), pp.4557-4569. ⟨10.1242/dev.124.22.4557⟩ Journal articles hal-03831425v1
	Restricted Expression of a Novel Murineatonal-Related bHLH Protein in Undifferentiated Neural Precursors Gérard Gradwohl , Carol Fode , François Guillemot Developmental Biology, 1996, 180 (1), pp.227-241. ⟨10.1006/dbio.1996.0297⟩ Journal articles hal-04006998v1
	Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development Daniel Dumont , Guo-Hua Fong , Mira Puri , Gérard Gradwohl , Kari Alitalo Developmental Dynamics, 1995, 203 (1), pp.80-92. ⟨10.1002/aja.1002030109⟩ Journal articles hal-03836540v1
	Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. D Dumont , Gérard Gradwohl , G Fong , M Puri , M Gertsenstein Genes and Development, 1994, 8 (16), pp.1897-1909. ⟨10.1101/gad.8.16.1897⟩ Journal articles hal-03835243v1
	The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA G Gradwohl , J M De Murcia , M Molinete , F Simonin , M Koken Proceedings of the National Academy of Sciences of the United States of America, 1990, 87 (8), pp.2990-4. ⟨10.1073/pnas.87.8.2990⟩ Journal articles hal-02371463v1
	Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity F Simonin , J Menissier-de Murcia , O Poch , S Muller , G Gradwohl J Biol Chem, 1990, 265 (31), pp.19249-56 Journal articles hal-02371467v1
	Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase J Thibodeau , F Simonin , M Favazza , G Gradwohl , G Poirier FEBS Lett, 1990, 264 (1), pp.81-3. ⟨10.1016/0014-5793(90)80770-j⟩ Journal articles hal-02371465v1
	Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA J Menissier-de Murcia , M Molinete , G Gradwohl , F Simonin , G De Murcia J Mol Biol, 1989, 210 (1), pp.229-33. ⟨10.1016/0022-2836(89)90302-1⟩ Journal articles hal-02371462v1
	Expression of functional zinc finger domain of human poly(ADP-ribose)polymerase in E. coli G Gradwohl , J Ménissier De Murcia , M Molinete , F Simonin , G De Murcia Nucleic Acids Research, 1989, 17 (17), pp.7112. ⟨10.1093/nar/17.17.7112⟩ Journal articles hal-02371461v1
	Poly(ADP-ribose)polymerase: a novel finger protein A Mazen , J Menissier-de Murcia , M Molinete , F Simonin , G Gradwohl Nucleic Acids Research, 1989, 17 (12), pp.4689-98. ⟨10.1093/nar/17.12.4689⟩ Journal articles hal-02371460v1
	Zinc-binding proteins detected by protein blotting A Mazen , G Gradwohl , G De Murcia Anal Biochem, 1988, 172 (1), pp.39-42. ⟨10.1016/0003-2697(88)90408-3⟩ Journal articles hal-02371456v1
	Poly(ADP-ribose) polymerase forms loops with DNA G Gradwohl , A Mazen , G De Murcia Biochem Biophys Res Commun, 1987, 148 (3), pp.913-9. ⟨10.1016/s0006-291x(87)80219-x⟩ Journal articles hal-02371453v1

	Characterization of cell-fate decision landscapes by estimating transcription factor dynamics Sara Jiménez , Valérie Schreiber , Reuben Mercier , Gérard Gradwohl , Nacho Molina 2022 Preprints, Working Papers, ... hal-03843200v1

Gérard Gradwohl

Research domains

Skills

Publications

Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice

Characterization of cell-fate decision landscapes by estimating transcription factor dynamics

Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine

Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Ascl1 is required to specify a subset of ventromedial hypothalamic neurons

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas

Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

Pairing-up SOX to kick-start beta cell genesis

Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells

Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.

Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes.

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

Pancreatic islet and progenitor cell surface markers with cell sorting potential

Enteroendocrine cells and lipid absorption

Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival

Expression of neuropeptide Y and agouti-related peptide in the hypothalamic arcuate nucleus of newborn neurogenin3 null mutant mice

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist

Characterization of the proneural gene regulatory network during mouse telencephalon development

In vitro models of intestinal epithelial cell differentiation

Transcription Factors in Pancreatic Development

Temporal Control of Neurogenin3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types

Development of the endocrine pancreas

Genetic determinants of pancreatic epsilon-cell development.

Lack of TCF2/vHNF1 in mice leads to pancreas agenesis

Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.

Transcriptional program of the endocrine pancreas in mice and humans

Opposing actions of Arx and Pax4 in endocrine pancreas development

Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium

Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation

The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons

The activity of neurogenin1 is controlled by local cues in the zebrafish embryo

Restricted Expression of a Novel Murineatonal-Related bHLH Protein in Undifferentiated Neural Precursors

Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA

Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity

Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

Expression of functional zinc finger domain of human poly(ADP-ribose)polymerase in E. coli

Poly(ADP-ribose)polymerase: a novel finger protein

Zinc-binding proteins detected by protein blotting

Poly(ADP-ribose) polymerase forms loops with DNA

Characterization of cell-fate decision landscapes by estimating transcription factor dynamics