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Gérard Gradwohl

Directeur de Recherche Inserm (DR1), Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue laurent Fries, 67404 Illkirch, Eurométropole Strasbourg, France
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Characterization of cell-fate decision landscapes by estimating transcription factor dynamics

Sara Jiménez , Valérie Schreiber , Reuben Mercier , Gérard Gradwohl , Nacho Molina
Cell Reports Methods, 2023, pp.100512. ⟨10.1016/j.crmeth.2023.100512⟩
Journal articles inserm-04140681v1
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Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice

Florence Blot , Justine Marchix , Miriam Ejarque , Sara Jimenez , Aline Meunier
Cellular and Molecular Gastroenterology and Hepatology, 2023, ⟨10.1016/j.jcmgh.2023.02.013⟩
Journal articles hal-04007457v1
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Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Towards Goblet Cell Lineage in the Mouse Intestine

Hui Joyce Li , Subir Ray , Alper Kucukural , Gerard Gradwohl , Andrew Leiter
Cellular and Molecular Gastroenterology and Hepatology, 2021, 11 (2), pp.433-448. ⟨10.1016/j.jcmgh.2020.08.006⟩
Journal articles inserm-03455700v1

Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells

Kaare V. Grunddal , Sarah Tonack , Kristoffer L. Egerod , Jonanthan James Thompson , Natalia Petersen
Molecular metabolism, 2021, 51, ⟨10.1016/j.molmet.2021.101231⟩
Journal articles hal-03708073v1
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Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Valérie Schreiber , Reuben Mercier , Sara Jiménez , Tao Ye , Emmanuel García-Sánchez
Molecular metabolism, 2021, 53, pp.101313. ⟨10.1016/j.molmet.2021.101313⟩
Journal articles hal-03454968v1
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Ascl1 is required to specify a subset of ventromedial hypothalamic neurons

Shaghayegh Aslanpour , Jessica M Rosin , Anjali Balakrishnan , Natalia Klenin , Florence Blot
Development (Cambridge, England), 2020, 147 (10), pp.dev180067. ⟨10.1242/dev.180067⟩
Journal articles inserm-03229584v1
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A transcriptomic roadmap to α- and β-cell differentiation in the embryonic pancreas

Léon van Gurp , Mauro Muraro , Tim Dielen , Lina Seneby , Gitanjali Dharmadhikari
Development (Cambridge, England), 2019, 146 (12), pp.dev173716. ⟨10.1242/dev.173716⟩
Journal articles inserm-02438309v1
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Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

Julie Piccand , Constance Vagne , Florence Blot , Aline Meunier , Anthony Beucher
Molecular metabolism, 2019, 29, pp.24-39. ⟨10.1016/j.molmet.2019.08.007⟩
Journal articles hal-02361214v1
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Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas

Laure Nivlet , Joel Herrmann , Delia Esteban Martin , Aline Meunier , Christophe Orvain
Journal of Molecular Endocrinology, 2016, 56 (2), pp.77-90. ⟨10.1530/JME-15-0213⟩
Journal articles inserm-03455716v1
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STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

S de Groef , D Renmans , Y Cai , G Leuckx , S Roels
Cell Death and Disease, 2016, 7 (6), pp.e2272-e2272. ⟨10.1038/cddis.2016.171⟩
Journal articles inserm-03455713v1

Pairing-up SOX to kick-start beta cell genesis

Anne Grapin-Botton , Philip Allan Seymour , Gerard Gradwohl
Diabetologia, 2015, 58 (5), pp.859-861. ⟨10.1007/s00125-015-3539-2⟩
Journal articles hal-04314988v1
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Differentially Expressed MicroRNA-483 Confers Distinct Functions in Pancreatic β- and α-Cells

Ramkumar Mohan , Yiping Mao , Shungang Zhang , Yu-Wei Zhang , Cheng-Ran Xu
Journal of Biological Chemistry, 2015, 290 (32), pp.19955-19966. ⟨10.1074/jbc.M115.650705⟩
Journal articles hal-04004363v1
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Rfx6 Maintains the Functional Identity of Adult Pancreatic β Cells

Julie Piccand , Perrine Strasser , David J. Hodson , Aline Meunier , Tao Ye
Cell Reports, 2014, 9 (6), pp.2219-2232
Journal articles hal-04004335v1

Pak3 Promotes Cell Cycle Exit and Differentiation of β-Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice

Julie Piccand , Aline Meunier , Carole Merle , Zhengping Jia , Jean-Vianney Barnier
Diabetes, 2014, 63 (1), pp.203-215. ⟨10.2337/db13-0384⟩
Journal articles hal-04091976v1

Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.

Julie Piccand , Aline Meunier , Carole Merle , Zhengping Jia , Jean-Vianney Barnier
Diabetes, 2013, 63 (1), pp.203-15. ⟨10.2337/db13-0384⟩
Journal articles hal-01181234v1

Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes.

Keith Al-Hasani , Anja Pfeifer , Monica Courtney , Nouha Ben-Othman , Elisabet Gjernes
Developmental Cell, 2013, epub ahead of print. ⟨10.1016/j.devcel.2013.05.018⟩
Journal articles hal-00843533v1

Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Neal Anthwal , Michelle Pelling , Suzanne Claxton , Georg Mellitzer , Caitlin Collin
Disease Models & Mechanisms, 2013, ⟨10.1242/dmm.011916⟩
Journal articles hal-04006946v1

The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice.

Anthony Beucher , Elisabet Gjernes , Caitlin Collin , Monica Courtney , Aline Meunier
PLoS ONE, 2012, 7 (5), pp.e36449. ⟨10.1371/journal.pone.0036449⟩
Journal articles hal-00760293v1

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

Anthony Beucher , Mercè Martin , Caroline Spenle , Martine Poulet , Caitlin Collin
Developmental biology, 2012, 361 (2), pp.277-285. ⟨10.1016/j.ydbio.2011.10.025⟩
Journal articles hal-04210579v1

Pancreatic islet and progenitor cell surface markers with cell sorting potential

J Hald , T Galbo , C Rescan , L Radzikowski , A Sprinkel
Diabetologia, 2012, 55 (1), pp.154-165. ⟨10.1007/s00125-011-2295-1⟩
Journal articles hal-04354737v1

Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus

Michelle Pelling , Neal Anthwal , David Mcnay , Gerard Gradwohl , Andrew Leiter
Developmental Biology, 2011, 349 (2), pp.406-416. ⟨10.1016/j.ydbio.2010.11.007⟩
Journal articles hal-04006971v1
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Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival

Georg Mellitzer , Anthony Beucher , Viviane Lobstein , Pascal Michel , Sylvie Robine
Journal of Clinical Investigation, 2010, 120 (5), pp.1708-1721. ⟨10.1172/JCI40794⟩
Journal articles hal-04004280v1

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

Josselin Soyer , Lydie Flasse , Wolfgang Raffelsberger , Anthony Beucher , Christophe Orvain
Development: For advances in developmental biology and stem cells, 2010, 137 (2), pp.203-212. ⟨10.1242/dev.041673⟩
Journal articles hal-04088194v1

Expression of neuropeptide Y and agouti-related peptide in the hypothalamic arcuate nucleus of newborn neurogenin3 null mutant mice

Yuta Arai , Gerard Gradwohl , Yoko Kameda
Cell and Tissue Research, 2010, 340 (1), pp.137-145. ⟨10.1007/s00441-009-0925-4⟩
Journal articles hal-04040219v1

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.

Tatiana V Petrova , Antti Nykänen , Camilla Norrmén , Konstantin I Ivanov , Leif C Andersson
Cancer Cell, 2008, 13 (5), pp.407-19. ⟨10.1016/j.ccr.2008.02.020⟩
Journal articles hal-00282904v1

GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist

Nayeem Quayum , Alecksandr Kutchma , Suparna A. Sarkar , Kirstine Juhl , Gerard Gradwohl
Experimental Diabetes Research, 2008, 2008, ⟨10.1155/2008/312060⟩
Journal articles hal-04118007v1
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Characterization of the proneural gene regulatory network during mouse telencephalon development

Julia M. Gohlke , Olivier Armant , Frederick M. Parham , Marjolein V. Smith , Celine Zimmer
BMC Biology, 2008, 6, ⟨10.1186/1741-7007-6-15⟩
Journal articles hal-04098272v1

Temporal Control of Neurogenin3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types

Kerstin Johansson , Umut Dursun , Nathalie Jordan , Guoqiang Gu , Friedrich Beermann
Developmental Cell, 2007, 12 (3), pp.457-465. ⟨10.1016/j.devcel.2007.02.010⟩
Journal articles hal-04006988v1

Transcription Factors in Pancreatic Development

Merce Martin , Viviane Hauer , Mélanie Messmer , Christophe Orvain , Gérard Gradwohl
Endocrine Development, 2007, pp.24-32. ⟨10.1159/000109602⟩
Journal articles hal-04117367v1

In vitro models of intestinal epithelial cell differentiation

Patricia Simon-Assmann , N. Turck , M. Sidhoum-Jenny , Gérard Gradwohl , Michèle Kedinger
Cell Biology and Toxicology, 2007, 23 (4), pp.241-256. ⟨10.1007/s10565-006-0175-0⟩
Journal articles hal-04106090v1

Development of the endocrine pancreas

Gérard Gradwohl
Diabetes & Metabolism, 2006, 32 (5), pp.532-533. ⟨10.1016/S1262-3636(06)72807-5⟩
Journal articles hal-04093892v1

Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.

Mercè Martín , Jabier Gallego-Llamas , Vanessa Ribes , Michèle Kedinger , Karen Niederreither
Developmental Biology, 2005, 284 (2), pp.399-411. ⟨10.1016/j.ydbio.2005.05.035⟩
Journal articles hal-00187679v1

Lack of TCF2/vHNF1 in mice leads to pancreas agenesis

C. Haumaitre , E. Barbacci , M. Jenny , M. Ott , Gérard Gradwohl
Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (5), pp.1490-1495. ⟨10.1073/pnas.0405776102⟩
Journal articles hal-04129661v1

Genetic determinants of pancreatic epsilon-cell development.

R Scott Heller , Marjorie Jenny , Patrick Collombat , Ahmed Mansouri , Catherine Tomasetto
Developmental Biology, 2005, 286 (1), pp.217-24. ⟨10.1016/j.ydbio.2005.06.041⟩
Journal articles hal-00187550v1

Transcriptional program of the endocrine pancreas in mice and humans

Klaus H. Kaestner , Catherine S. Lee , L. Marie Scearce , John E. Brestelli , Athanasios Arsenlis
Diabetes, 2003, 52 (7), pp.1604-1610. ⟨10.2337/diabetes.52.7.1604⟩
Journal articles hal-04143730v1

Opposing actions of Arx and Pax4 in endocrine pancreas development

Patrick Collombat , Ahmed Mansouri , Jacob Hecksher-Sorensen , Palle Serup , Jens Krull
Genes and Development, 2003, 17 (20), pp.2591-2603. ⟨10.1101/gad.269003⟩
Journal articles hal-04138430v1

Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium

Marjorie Jenny , Céline Uhl , Colette Roche , Isabelle Duluc , Valérie Guillermin
The EMBO Journal, 2002, 21 (23), pp.6338-6347. ⟨10.1093/emboj/cdf649⟩
Journal articles hal-03812784v1

Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord

Raffaella Scardigli , Carol Schuurmans , Gerard Gradwohl , François Guillemot
Neuron, 2001, 31 (2), pp.203-217. ⟨10.1016/s0896-6273(01)00358-0⟩
Journal articles hal-04112682v1

Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3

Patrick Jacquemin , Serge M. Durviaux , Jan Jensen , Catherine Godfraind , Gerard Gradwohl
Molecular and cellular biology, 2000, 20 (12), pp.4445-4454. ⟨10.1128/MCB.20.12.4445-4454.2000⟩
Journal articles hal-04128943v1

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

Gérard Gradwohl , Andrée Dierich , Marianne Lemeur , François Guillemot
Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (4), pp.1607-1611. ⟨10.1073/pnas.97.4.1607⟩
Journal articles hal-04006991v1

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation

Toshiyuki Ohtsuka , Makoto Ishibashi , Gerard Gradwohl , Shigetada Nakanishi , François Guillemot
EMBO Journal, 1999, 18 (8), pp.2196-2207. ⟨10.1093/emboj/18.8.2196⟩
Journal articles hal-04027634v1

The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons

Carol Fode , Gérard Gradwohl , Xavier Morin , Andrée Dierich , Marianne Lemeur
Neuron, 1998, 20 (3), pp.483-494. ⟨10.1016/s0896-6273(00)80989-7⟩
Journal articles hal-04007011v1

The activity of neurogenin1 is controlled by local cues in the zebrafish embryo

P Blader , Natacha Schroeder , Gerard Gradwohl , F Guillemot , U Strähle
Development (Cambridge, England), 1997, 124 (22), pp.4557-4569. ⟨10.1242/dev.124.22.4557⟩
Journal articles hal-03831425v1

Restricted Expression of a Novel Murineatonal-Related bHLH Protein in Undifferentiated Neural Precursors

Gérard Gradwohl , Carol Fode , François Guillemot
Developmental Biology, 1996, 180 (1), pp.227-241. ⟨10.1006/dbio.1996.0297⟩
Journal articles hal-04006998v1

Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development

Daniel Dumont , Guo-Hua Fong , Mira Puri , Gérard Gradwohl , Kari Alitalo
Developmental Dynamics, 1995, 203 (1), pp.80-92. ⟨10.1002/aja.1002030109⟩
Journal articles hal-03836540v1

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

D Dumont , Gérard Gradwohl , G Fong , M Puri , M Gertsenstein
Genes and Development, 1994, 8 (16), pp.1897-1909. ⟨10.1101/gad.8.16.1897⟩
Journal articles hal-03835243v1

Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase

J Thibodeau , F Simonin , M Favazza , G Gradwohl , G Poirier
FEBS Lett, 1990, 264 (1), pp.81-3. ⟨10.1016/0014-5793(90)80770-j⟩
Journal articles hal-02371465v1

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA

G Gradwohl , J M De Murcia , M Molinete , F Simonin , M Koken
Proceedings of the National Academy of Sciences of the United States of America, 1990, 87 (8), pp.2990-4. ⟨10.1073/pnas.87.8.2990⟩
Journal articles hal-02371463v1

Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity

F Simonin , J Menissier-de Murcia , O Poch , S Muller , G Gradwohl
J Biol Chem, 1990, 265 (31), pp.19249-56
Journal articles hal-02371467v1

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

J Menissier-de Murcia , M Molinete , G Gradwohl , F Simonin , G De Murcia
J Mol Biol, 1989, 210 (1), pp.229-33. ⟨10.1016/0022-2836(89)90302-1⟩
Journal articles hal-02371462v1

Expression of functional zinc finger domain of human poly(ADP-ribose)polymerase in E. coli

G Gradwohl , J Ménissier De Murcia , M Molinete , F Simonin , G De Murcia
Nucleic Acids Research, 1989, 17 (17), pp.7112. ⟨10.1093/nar/17.17.7112⟩
Journal articles hal-02371461v1

Poly(ADP-ribose)polymerase: a novel finger protein

A Mazen , J Menissier-de Murcia , M Molinete , F Simonin , G Gradwohl
Nucleic Acids Research, 1989, 17 (12), pp.4689-98. ⟨10.1093/nar/17.12.4689⟩
Journal articles hal-02371460v1

Zinc-binding proteins detected by protein blotting

A Mazen , G Gradwohl , G De Murcia
Anal Biochem, 1988, 172 (1), pp.39-42. ⟨10.1016/0003-2697(88)90408-3⟩
Journal articles hal-02371456v1

Poly(ADP-ribose) polymerase forms loops with DNA

G Gradwohl , A Mazen , G De Murcia
Biochem Biophys Res Commun, 1987, 148 (3), pp.913-9. ⟨10.1016/s0006-291x(87)80219-x⟩
Journal articles hal-02371453v1