Access content directly

Guillaume Pidoux

Researcher identifiers


Civil Status ============ Pidoux Guillaume French 17th July 1978 Function: ========= Senior Researcher (CRCN) INSERM with permanent position French Public Organization: =========================== INSERM UMR-S1180 - Signalling &amp; Cardiovascular Pathophysiology - Faculty of Pharmacy - University Paris Saclay <> Other activities: ================= *Executive board* ----------------- 2010-2015 Team leader of the Cell Fusion group Inserm UMR-S767 2013-2015 Supervision of postdoctoral fellow (S. Degrelle granted by ANR Grant 11-BSV1-03501) 2010-2015 Supervision of permanent Inserm technician (F. Ferreira) and engineer (P. Gerbaud) 2021-2024 Supervision of postdoctoral fellow (to be recruited granted by ANR Grant CardioTarget) *Supervision of students* ------------------------- 2004-2018 Supervision and trainings of 10 master students (7 x M2, 3 x M1) 2013-2016 Co-supervision of a PhD fellow with Pr. K. Tasken (A. Dukic, PhD defended 12th December 2016) 2017-2021 Co-supervision of a PhD fellow with Dr. R. Fischmeister (C. Deflers; CIFRE fellowship &amp; FRM) 2018-2022 Supervision of a PhD fellow (AS. Colombe; LabEx fellowship) *Memberships in panel university committee* ------------------------------------------- 2014 PhD committee, France, University Descartes (Bandje K.) 2015 PhD committee, France, University Paris-Sud (Bobin P.) 2019 Mid-PhD committee, Swiss, Lausanne University (Osman H.) (defense expected in 2022) 2019 PhD committee, France, University Paris-Saclay (Gallego C.) 2020 HDR committee, France, University Versailles-Saint-Quentin (Tarrade-Couturier A.) *Memberships in individual scientific reviewing activities* ----------------------------------------------------------- 2018-2018 LabEx Lermit Emergence grant review committee 2019-2019 H2020: ERC Starting grant LS9 reviewer 2020-2020 Ligue Suisse contre le Cancer reviewer 2020-2020 GAČR: Czech Science Foundation reviewer *Animation &amp; Network* ------------------------- Since 2011 Co-director of the French cAMP Network 2011-2016 Elected member of the EPG Planning committee by EPG (European Placenta Group) 2018 Member of CoLab LabEx Lermit 2020 Member of joined CoPil &amp; CoLab LabEx Lermit *Teaching activities* (≈ 10h / year) ------------------------------------ Since 2019 Master biology, physiopathology, pharmacology of the heart and circulation (*University Paris-Saclay*) 2020 International Master Development of Drugs and Health Products (*in English, University Paris-Saclay*) *Reviewing manuscript* ---------------------- Reviewing on a regular basis (≈ 20 / year): *Endocrinology, J Cell Sci, Mol Cell Biol, MBoC, J Cell Physiol, Sci. Reports, PloS One, Cell Signaling, BBA, Cells, Biomolecules, iScience ..*. *Metrics (September 2020)* -------------------------- 44 publications (Web of Knowledge), h-index 15 (Web of Knowledge) **ORCID ID: 0000-0002-5074-429X** Previous Positions ================== 01/01/2007-31/12/2009 - OSLO - EMBL Nordic - NCMM - Postdoc 01/01/2010-31/08/2012 - PARIS - INSERM UMR-S767 - Postdoc 01/09/2012-31/07/2015 - PARIS - INSERM UMR-S767 - Inserm Junior Researcher (CR2) 01/08/2015- - Chatenay-Malabry - INSERM UMR-S1180 - Inserm Researcher (CRCN) Education ========= 2000 University Paris-Sud, Orsay, France B.Sc. Cell biology, physiology 2002 University Paris-Sud, Orsay, France Master Cell biology, physiology 2006 University Paris-Diderot, Paris, France Ph.D. Cell biology, physiology 2013 University Paris-Descartes, Paris, France Habilitation (HDR) Cell signaling Scientific production ===================== *Grants* -------- 2011 Grant Yggdrasil (collaborative France – Norway) (18 k€) 2012-2015 Co-partner of ANR (French National Agency) Grant 11-BSV1-03501-PlacentA5 (340 k€) 2012-2014 Grant INSERM (40 k€) 2013 Funding CAMPLP for equipment (30 k€) 2021-2024 Coordinator of ANR (French National Agency) Grant ANR-20-CE18-0017 (401 k€) *Prizes* -------- 2012 Gordon Research Conference best short communication, Cyclic Nucleotide Phosphodiesterases (Italy) 2012 Nominated for Gábor Than Award 2012 SFBBM award for the best scientific paper of the month (March 2012, *EMBO J*) *Fellowships* ------------- 2002-2006 PhD Fellowship “Avenir-Inserm”, INSERM 2007-2010 Laureate of the European fellowship EMBiO “metabolic disorders”, UiO, Norway 2010 FEBS fellowship to attend to the workshop “spatiotemporal dynamics of cell signalling” (Norway) 2010 SFBBM fellowship to attend to the 35th FEBS congress (Sweden) 2010-2012 Postdoc Fellowship from Fondation PremUP, Univ. Paris Descartes, France ***Training*** · *Management* 2013 Scientific team management - session for facility directors, team leaders and researchers (Inserm) 2013 Recruitment of scientific team 2013 Supervise and support your PhD fellow · *Research support* 2005 Animal experiment diploma (French Level-1) 2012 Adobe Illustrator 2014 GraphPad Prism 2014 Biological statistics 2014 Image processing and analysis 2015 Programing and macro-control under ImageJ Valorization ============ 2012 Pidoux G. &amp; Tasken K. DOFI no. 12043: Method to regulate the opening of connexin-43 junctions


Study of Human T21 Placenta Suggests a Potential Role of Mesenchymal Spondin-2 in Placental Vascular Development

Pascale Gerbaud , Padma Murthi , Jean Guibourdenche , Fabien Guimiot , Benoît Sarazin
Endocrinology, 2019, 160 (3), pp.684-698. ⟨10.1210/en.2018-00826⟩
Journal articles inserm-02472525v1

Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion

Aleksandra Dukic , Pascale Gerbaud , Jean Guibourdenche , Bernd Thiede , Kjetil Taskén
Biochemical Journal, 2018, 475 (2), pp.455-476. ⟨10.1042/BCJ20170529⟩
Journal articles inserm-02472530v1

A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells

Aleksandra Dukic , Linda Hofstad Haugen , Guillaume Pidoux , Edward Leithe , Oddmund Bakke
Cellular Signalling, 2017, 32, pp.1-11. ⟨10.1016/j.cellsig.2017.01.008⟩
Journal articles inserm-02472534v1
Image document

Annexin-A5 organized in 2D-network at the plasmalemma eases human trophoblast fusion OPEN

Severine S. Degrelle , Pascale Gerbaud , Ludovic Leconte , Fátima Ferreira , Guillaume Pidoux
Scientific Reports, 2017, 7 (1), pp.42173. ⟨10.1038/srep42173⟩
Journal articles inserm-02440462v1

[Role and regulation of cAMP signaling in human trophoblast fusion].

Pascale Gerbaud , Fatima Ferreira , Guillaume Pidoux
Biologie Aujourd'hui, 2016, 210 (3), pp.139-151. ⟨10.1051/jbio/2016017⟩
Journal articles inserm-02472540v1

Fluid Shear Stress Promotes Placental Growth Factor Upregulation in Human Syncytiotrophoblast Through the cAMP–PKA Signaling Pathway

Edouard Lecarpentier , Anthony Atallah , Jean Guibourdenche , Marylise Hebert-Schuster , Sarah Vieillefosse
Hypertension, 2016, 68 (6), pp.1438-1446. ⟨10.1161/HYPERTENSIONAHA.116.07890⟩
Journal articles inserm-02472544v1
Image document

Formaldehyde Crosses the Human Placenta and Affects Human Trophoblast Differentiation and Hormonal Functions

Guillaume Pidoux , Pascale Gerbaud , Jean Guibourdenche , Patrice Therond , Fatima Ferreira
PLoS ONE, 2015, 10 (7), pp.e0133506. ⟨10.1371/journal.pone.0133506⟩
Journal articles inserm-02472555v1

Anchored PKA as a gatekeeper for gap junctions

Guillaume Pidoux , Kjetil Taskén
Communicative and Integrative Biology, 2015, 8 (4), pp.e1057361. ⟨10.1080/19420889.2015.1057361⟩
Journal articles inserm-02472545v1
Image document

Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion

Pascale Gerbaud , Kjetil Taskén , Guillaume Pidoux
Frontiers in Pharmacology, 2015, 6, pp.202. ⟨10.3389/fphar.2015.00202⟩
Journal articles inserm-02472551v1
Image document

An overview of molecular events occurring in human trophoblast fusion

Pascale Gerbaud , Guillaume Pidoux
Placenta, 2015, 36 (Suppl1), pp.S35-42. ⟨10.1016/j.placenta.2014.12.015⟩
Journal articles inserm-02556112v2
Image document

A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion

Guillaume Pidoux , Pascale Gerbaud , Jim Dompierre , Birgitte Lygren , Therese Solstad
Journal of Cell Science, 2014, 129 (Pt19), pp.4172-4185. ⟨10.1242/jcs.149609⟩
Journal articles inserm-02556121v1
Image document

Pattern of secretion of pregnancy-associated plasma protein-A (PAPP-A) during pregnancies complicated by fetal aneuploidy, in vivo and in vitro

Marie Clémence Leguy , Stéphanie Brun , Guillaume Pidoux , Houria Salhi , Agnès Choiset
Reproductive Biology and Endocrinology, 2014, ⟨10.1186/1477-7827-12-129⟩
Journal articles inserm-02556117v1
Image document

Review: Human trophoblast fusion and differentiation: Lessons from trisomy 21 placenta

Guillaume Pidoux , Pascale Gerbaud , Mélanie Cocquebert , Nadine Segond , Josette Badet
Placenta, 2012, 33, Suppl:S81-86. ⟨10.1016/j.placenta.2011.11.007⟩
Journal articles inserm-02556136v1
Image document

IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells

W E Ackerman Iv , J N Bulmer , A M Carter , J R Chaillet , L Chamley
Placenta, 2012, 33 (Suppl(0)), pp.S15-22. ⟨10.1016/j.placenta.2011.11.022⟩
Journal articles inserm-02556127v1
Image document

Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis

Guillaume Pidoux , Oliwia Witczak , Elisabeth Jarnaess , Linda Myrvold , Henning Urlaub
EMBO Journal, 2011, 30 (21), pp.4371-4386. ⟨10.1038/emboj.2011.365⟩
Journal articles inserm-02556141v1
Image document

Mesenchymal Activin-A Overcomes Defective Human Trisomy 21 Trophoblast Fusion

Pascale Gerbaud , Guillaume Pidoux , Jean Guibourdenche , Niroshani Pathirage , Jean Marc Costa
Endocrinology, 2011, 152 (12), pp.5017-5028. ⟨10.1210/en.2011-1193⟩
Journal articles inserm-02556144v1
Image document

REVIEW Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

Guillaume Pidoux , Kjetil Taské
Journal of Molecular Endocrinology, 2010, 44 (5), pp.271-284. ⟨10.1677/JME-10-0010⟩
Journal articles inserm-02556153v1

ZO-1 is involved in trophoblastic cell differentiation in human placenta.

Guillaume Pidoux , Pascale Gerbaud , Sédami Gnidehou , Michael Grynberg , Graziello Geneau
American Journal of Physiology - Cell Physiology, 2010, 298 (6), pp.C1517-26. ⟨10.1152/ajpcell.00484.2008⟩
Journal articles hal-00498310v1
Image document

Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies.

Guillaume Pidoux , Pascale Gerbaud , Olivier Marpeau , Jean Guibourdenche , Fatima Ferreira
Endocrinology, 2007, 148 (11), pp.5403-13. ⟨10.1210/en.2007-0589⟩
Journal articles inserm-00168635v1
Image document

Biochemical characterization and modulation of LH/CG-receptor during human trophoblast differentiation.

Guillaume Pidoux , Pascale Gerbaud , Vassilis Tsatsaris , Olivier Marpeau , Fatima Ferreira
Journal of Cellular Physiology, 2007, 212 (1), pp.26-35. ⟨10.1002/jcp.20995⟩
Journal articles inserm-00116966v1
Image document

Large Variability of Trophoblast Gene Expression Within and Between Human Normal Term Placentae

Guillaume Pidoux , Pascale Gerbaud , Ingrid Laurendeau , Jean Guibourdenche , G Bertin
Placenta, 2004, 25 (5), pp.469-473. ⟨10.1016/j.placenta.2003.10.016⟩
Journal articles inserm-02556159v1
Image document

Trophoblast production of a weakly bioactive human chorionic gonadotropin in trisomy 21-affected pregnancy.

Jean-Louis Frendo , Jean Guibourdenche , Guillaume Pidoux , Michel Vidaud , Dominique Luton
Journal of Clinical Endocrinology and Metabolism, 2004, 89 (2), pp.727-32. ⟨10.1210/jc.2003-030668⟩
Journal articles inserm-00128419v1
Image document

Impact of Trisomy 21 on Human Trophoblast Behaviour and Hormonal Function

Guillaume Pidoux , Jean Guibourdenche , Jean-Louis Frendo , Pascale Gerbaud , M Conti
Placenta, 2004, 25 (SupplA), pp.S79-84. ⟨10.1016/j.placenta.2004.01.007⟩
Journal articles inserm-02556164v1
Image document

Requirement of Gap Junctional Intercellular Communication for Human Villous Trophoblast Differentiation 1

Laurent Cronier , Jean-Louis Frendo , Norah Defamie , Guillaume Pidoux , Gladys Bertin
Biology of Reproduction, 2003, 69 (5), pp.1472-1480. ⟨10.1095/biolreprod.103.016360⟩
Journal articles inserm-02556169v1
Image document

Compartimentation des nucléotides cycliques dans le coeur

Grégoire Vandecasteele , Delphine Mika , Guillaume Pidoux , Rodolphe Fischmeister
Biologie et pathologie du coeur et des vaisseaux", GRRC, 3ème édition, éditions JOHN LIBBEY EUROTEXT. 2019., pp.47-54, 2019
Book sections hal-02896626v1

Human Trophoblast in Trisomy 21: A Model for Cell–Cell Fusion Dynamic Investigation

André Malassiné , Guillaume Pidoux , Pascale Gerbaud , Jean Louis Frendo , Danièle Evain-Brion
Advances in Experimental Medicine and Biology book series, pp.103-112, 2011, ⟨10.1007/978-94-007-0782-5_4⟩
Book sections inserm-02556149v1