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Guy Lippens

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***Curriculum Vitae*** **Guy Lippens, PhD** **Research Director** (DR1) at **CNRS**, Chemistry Department TBI, UMR5504, INSA Toulouse, 31400 Toulouse September 30th 1964 Citizenship : Belgium Gender : Male Degrees **June 1987** : Engineering degree (*maxima cum lauda*), University of Ghent, Belgium. **January 1989** : **Master’s degree** in Applied and Engineering Physcis, *Hydrogen diffusion in metal hydrides.* Cornell University, Ithaca, NY (USA) **March 1992** : **Ph.D.**, *NMR structure of oxytocin bound to neurophysin*, University of Ghent, Belgium. **April 1995** : **HDR**, University of Science and Technology Lille 1, *Functional and structural study of phospho-binding proteins involved in cell cycle regulation ,* Lille, France Training July 1987 - Jan 1989: **Graduate Student**, Applied and Engineering Physics, Cornell University, Ithaca (USA) February 1989 - April 1992: **Graduate Student**, University of Ghent/Free University of Brussels, Belgium. May 1992 - September 1993: **Post-doctoral research** fellow, UMR8525, Pasteur Institute of Lille, France Awards June 1987 : Belgian American Educational Fellowship (BAEF) June 1988 : IBM Graduate Fellowship January 2012 : UK Alzheimer’s society Oral Communication Prize Academic appointments Oct. **1993** : **Research Scientist** CR1 UMR-CNRS 8525, Pasteur Institute of Lille, France Oct. **1999** : **Research Director** DR2 UMR-CNRS 8525, Pasteur Institute of Lille, France Oct. **2008** : **Research Director** DR1 UMR-CNRS 8576, University Lille 1, Lille, France Sept. **2015**: **Research Director** DR1 UMR-CNRS 5504, INSA Toulouse, France Publications: 190, h-Index 46


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Structural and Biochemical Characterization of a Nonbinding SusD-Like Protein Involved in Xylooligosaccharide Utilization by an Uncultured Human Gut Bacteroides Strain

Alexandra Tauzin , Zhi Wang , Gianluca Cioci , Xiaoqian Li , Aurore Labourel
MSphere, 2023, 7 (5), ⟨10.1128/msphere.00244-22⟩
Journal articles hal-03796391v1
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Proline-Rich Region II (PRR2) Plays an Important Role in Tau–Glycan Interaction: An NMR Study

Anqesha Murray , Lufeng Yan , James Gibson , Jian Liu , David Eliezer
Biomolecules, 2022, 12 (11), pp.1573. ⟨10.3390/biom12111573⟩
Journal articles hal-03832416v1
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Characterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl− Current in Vascular Myocytes

Jean-Luc Morel , Nathalie Mokrzycki , Guy Lippens , Hervé Drobecq , Pierre Sautière
Toxins, 2022, 14 (11), pp.780. ⟨10.3390/toxins14110780⟩
Journal articles hal-03864126v1
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An NMR look at an engineered PET depolymerase

Cyril Charlier , Sabine Gavalda , Vinciane Borsenberger , Sophie Duquesne , Alain Marty
Biophysical Journal, inPress, ⟨10.1016/j.bpj.2022.07.002⟩
Journal articles hal-03739009v1
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Improved NMR Detection of Phospho-Metabolites in a Complex Mixture

Neil Cox , Pierre Millard , Cyril Charlier , Guy Lippens
Analytical Chemistry, 2021, 93 (11), pp.4818-4824. ⟨10.1021/acs.analchem.0c04056⟩
Journal articles hal-03171690v2
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Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis

Anastasiia Grigoreva , Julia Andreeva , Dmitry Bikmetov , Anastasiia Rusanova , Marina Serebryakova
iScience, 2021, 24 (5), ⟨10.1016/j.isci.2021.102480⟩
Journal articles hal-03270626v1
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The Jo-In protein welding system is a relevant tool to create CBM-containing plant cell wall degrading enzymes

Louise Badruna , Vincent Burlat , Pierre Roblin , Thomas Enjalbert , Guy Lippens
New Biotechnology, 2021, 65, pp.31-41. ⟨10.1016/j.nbt.2021.07.004⟩
Journal articles hal-03340154v1
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The covalent complex of Jo-In results from a long-lived, non-covalent intermediate state with near-native structure

Neil Cox , Cyril Charlier , Ramadoss Vijayaraj , Marion de La Mare , Sophie Barbe
Biochemical and Biophysical Research Communications, 2021, 589, pp.223-228. ⟨10.1016/j.bbrc.2021.12.028⟩
Journal articles hal-03554277v1

IsoSolve: An Integrative Framework to Improve Isotopic Coverage and Consolidate Isotopic Measurements by Mass Spectrometry and/or Nuclear Magnetic Resonance

Pierre Millard , Serguei Sokol , Michael Kohlstedt , Christoph Wittmann , Fabien Létisse
Analytical Chemistry, 2021, 93 (27), pp.9428-9436. ⟨10.1021/acs.analchem.1c01064⟩
Journal articles hal-03307270v1
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Virtual decoupling to break the simplification versus resolution trade-off in nuclear magnetic resonance of complex metabolic mixtures

Cyril Charlier , Neil Cox , Sophie Prud'Homme , Alain Geffard , Jean-Marc Nuzillard
Magnetic Resonance, 2021, 2, pp.619-627. ⟨10.5194/mr-2-619-2021⟩
Journal articles hal-03338624v1

Increasing field strength versus advanced isotope labeling for NMR based fluxomics

Mickael Dinclaux , Edern Cahoreau , Pierre Millard , Fabien Letisse , Guy Lippens
Magnetic Resonance in Chemistry, 2020, pp.1-7. ⟨10.1002/mrc.4988⟩
Journal articles hal-02438088v1
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The Zebra Mussel (Dreissena polymorpha) as a Model Organism for Ecotoxicological Studies: A Prior 1H NMR Spectrum Interpretation of a Whole Body Extract for Metabolism Monitoring

Sophie Martine Prud’homme , Younes Mohamed Ismail Hani , Neil Cox , Guy Lippens , Jean-Marc Nuzillard
Metabolites, 2020, 10 (6), pp.256. ⟨10.3390/metabo10060256⟩
Journal articles hal-02934872v1

Backbone chemical shift assignment of macrophage infectivity potentiator virulence factor of Trypanosoma cruzi

Juan M. Lopez , Ricardo Antiparra , Guy Lippens , Mirko Zimic , Patricia Sheen
Biomolecular NMR Assignments, 2019, 13 (1), pp.21-25. ⟨10.1007/s12104-018-9844-1⟩
Journal articles hal-02170460v1
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Efficient Access to Deuterated and Tritiated Nucleobase Pharmaceuticals and Oligonucleotides using Hydrogen-Isotope Exchange

Alberto Palazzolo , Sophie Feuillastre , Viktor Pfeifer , Sébastien Garcia-Argote , Donia Bouzouita
Angewandte Chemie International Edition, 2019, 58 (15), pp.4891-4895. ⟨10.1002/anie.201813946⟩
Journal articles cea-02075752v1

Futile Encounter Engineering of the DSR-M Dextransucrase Modifies the Resulting Polymer Length

Marion Claverie , Gianluca Cioci , Matthieu Guionnet , Julia Schörghuber , Roman Lichtenecker
Biochemistry, 2019, 58 (25), pp.2853-2859. ⟨10.1021/acs.biochem.9b00373⟩
Journal articles hal-02176417v1

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors

Clément Despres , Jing Di , François-Xavier Cantrelle , Zizheng Li , Isabelle Huvent
ACS Chemical Biology, 2019, 14 (6), pp.1363-1379. ⟨10.1021/acschembio.9b00325⟩
Journal articles hal-02317189v1
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Tuning the catalytic activity and selectivity of water-soluble bimetallic RuPt nanoparticles by modifying their surface metal distribution

Donia Bouzouita , Guy Lippens , Edwin A Baquero , Pier-Francesco Fazzini , Grégory Pieters
Nanoscale, 2019, 11 (35), pp.16544-16552. ⟨10.1039/C9NR04149D⟩
Journal articles hal-02283913v2

Integrated pH Measurement during Reaction Monitoring with Dual-Reception 1 H– 31 P NMR Spectroscopy

Neil Cox , Rainer Kuemmerle , Pierre Millard , Edern Cahoreau , Jean-Marie François
Analytical Chemistry, 2019, 91 (6), pp.3959-3963. ⟨10.1021/acs.analchem.8b05147⟩
Journal articles hal-02131891v1
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Elucidating Tau function and dysfunction in the era of cryo-EM

Guy Lippens , Benoît Gigant
Journal of Biological Chemistry, inPress, 294 (24), pp.9316-9325. ⟨10.1074/jbc.REV119.008031⟩
Journal articles hal-02137974v1

Efficient in vivo synthesis of lasso peptide pseudomycoidin proceeds in the absence of both the leader and the leader peptidase

Tatyana Zyubko , Marina Serebryakova , Julia Andreeva , Mikhail Metelev , Guy Lippens
Chemical Science, 2019, 10 (42), pp.9699-9707. ⟨10.1039/C9SC02370D⟩
Journal articles hal-02368109v1
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Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

Marie Dujardin , Vanesa Madan , Neha S Gandhi , François-Xavier Cantrelle , Hélène Launay
Journal of Biological Chemistry, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
Journal articles hal-02998113v1

The Neuronal tau protein blocks in vitro fibrillation of the amyloid-beta (A beta) peptide at the oligomeric stage

Cecilia Wallin , Yoshitaka Hiruma , Sebastian K. T. S. Warmlander , Isabelle Huvent , Juri Jarvet
Journal of the American Chemical Society, 2018, 140 (26), pp.8138-8146. ⟨10.1021/jacs.7b13623⟩
Journal articles hal-02154329v1

In-cell NMR: from metabolites to macromolecules

Guy Lippens , Edern Cahoreau , Pierre Millard , C. Charlier , J. Lopez
Analyst, 2018, 143 (3), pp.620-629. ⟨10.1039/C7AN01635B⟩
Journal articles hal-01886451v1

Interaction study between HCV NS5A-D2 and NS5B using 19F NMR

Marie Dujardin , François-Xavier Cantrelle , Guy Lippens , Xavier Hanoulle
Journal of Biomolecular NMR, 2018, 70 (1), pp.67-76. ⟨10.1007/s10858-017-0159-9⟩
Journal articles hal-01886452v1

Improved Isotopic Profiling by Pure Shift Heteronuclear 2D J -Resolved NMR Spectroscopy

Davy Sinnaeve , Mickael Dinclaux , Edern Cahoreau , Pierre Millard , Jean-Charles Portais
Analytical Chemistry, 2018, 90 (6), pp.4025-4031. ⟨10.1021/acs.analchem.7b05206⟩
Journal articles hal-02131883v1

Metabolic phenotyping of human plasma by H-1-NMR at high and medium magnetic field strengths: a case study for lung cancer

Evelyne Louis , Francois-Xavier Cantrelle , Liesbet Mesotten , Gunter Reekmans , Liene Bervoets
Magnetic Resonance in Chemistry, 2017, 55 (8), pp.706-713. ⟨10.1002/mrc.4577⟩
Journal articles hal-01886450v1
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Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth Verstraete , Frank Peelman , Harald Braun , Juan Lopez , Dries van Rompaey
Nature Communications, 2017, 8 (1), 17 p. ⟨10.1038/ncomms14937⟩
Journal articles hal-01605011v1

Glycan Determinants of Heparin-Tau Interaction

Jing Zhao , Isabelle Huvent , Guy Lippens , David Eliezer , Anqiang Q. Zhang
Biophysical Journal, 2017, 112 (5), pp.921-932. ⟨10.1016/j.bpj.2017.01.024⟩
Journal articles hal-01600157v1
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Investigations on the Determinants Responsible for Low Molar Mass Dextran Formation by DSR-M Dextransucrase

Marion Claverie , Gianluca Cioci , Marlène Vuillemin , Nelly Monties , Pierre Roblin
ACS Catalysis, 2017, 7 (10), pp.7106-7119. ⟨10.1021/acscatal.7b02182⟩
Journal articles hal-01886431v1

Monitoring of nanoparticle reactivity in solution: interaction of l -lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange

Luis Miguel Martinez-Pietro , Edwin A Baquero , Grégory Pieters , Juan Flores , Ernesto de Jesus
Chemical Communications, 2017, 53 (43), pp.5850-5853. ⟨10.1039/c7cc02445b⟩
Journal articles hal-02004103v1

Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A

Aurélie Badillo , Véronique Receveur-Brechot , Stéphane Sarrazin , François-Xavier Cantrelle , Frédéric Delolme
Biochemistry, 2017, 56 (24), pp.3029 - 3048. ⟨10.1021/acs.biochem.7b00212⟩
Journal articles hal-01785410v1

(15)N-NMR-based approach for amino acids-based (13)C-metabolic flux analysis of metabolism

Pierre Millard , Edern Cahoreau , Maud Heuillet , Jean-Charles Portais , Guy Lippens
Analytical Chemistry, 2017, 89 (3), pp.2101-2106. ⟨10.1021/acs.analchem.6b04767⟩
Journal articles hal-01602563v1
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Identification of the Tau phosphorylation pattern that drives its aggregation

Clement Despres , Cillian Byrne , Haoling Qi , François-Xavier Cantrelle , Isabelle Huvent
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (34), pp.9080 - 9085. ⟨10.1073/pnas.1708448114⟩
Journal articles hal-01620128v1
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NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B

Luiza Bessa , Hélène Launay , Marie Dujardin , Xavier Cantrelle , Guy Lippens
Journal of Biological Chemistry, inPress, 292 (44), pp.18024-18043. ⟨10.1074/jbc.M117.813766⟩
Journal articles hal-01620117v1
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Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

Haoling Qi , Sudhakaran Prabakaran , François-Xavier Cantrelle , Béatrice Chambraud , Jeremy Gunawardena
Journal of Biological Chemistry, 2016, 291 (14), pp.7742 - 7753. ⟨10.1074/jbc.M115.700914⟩
Journal articles hal-01389831v1

Proline Conformation in a Functional Tau Fragment

Puneet Ahuja , Xavier Cantrelle , Isabelle Huvent , Xavier Hanoulle , Juan Lopez
Journal of Molecular Biology, 2016, 428 (1), pp.79 - 91. ⟨10.1016/j.jmb.2015.11.023⟩
Journal articles hal-01389832v1

Studying Intrinsically disordered proteins under true in vivo conditions by combined cross-polarization and carbonyl-detection NMR spectroscopy

Juan Lopez , Robert Schneider , Francois-Xavier Cantrelle , Isabelle Huvent , Guy Lippens
Angewandte Chemie International Edition, 2016, 55 (26), pp.7418-7422. ⟨10.1002/anie.201601850⟩
Journal articles hal-01886415v1
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NMR Meets Tau: Insights into Its Function and Pathology

Guy Lippens , Isabelle Landrieu , Caroline Smet , Isabelle Huvent , Neha Gandhi
Ancient biomolecules, 2016, 6 (2), ⟨10.3390/biom6020028⟩
Journal articles hal-01389829v1

A β-Turn Motif in the Steroid Hormone Receptor’s Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52

Cillian Byrne , Morkos A. Henen , Mathilde Belnou , François-Xavier Cantrelle , Amina Kamah
Biochemistry, 2016, 55 (38), pp.5366 - 5376. ⟨10.1021/acs.biochem.6b00506⟩
Journal articles hal-01389826v1

Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain

Yoann Sottejeau , Alexis Bretteville , François-Xavier Cantrelle , Nicolas Malmanche , Florie Demiaute
Acta Neuropathologica Communications, 2015, 3 (1), ⟨10.1186/s40478-015-0237-8⟩
Journal articles hal-01221659v1

A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein.

Neha S Gandhi , Isabelle Landrieu , Cillian Byrne , Predrag Kukic , Laziza Amniai
Angewandte Chemie International Edition, 2015, 127 (23), pp.6923-6927 ⟨10.1002/ange.201501898⟩
Journal articles hal-01145963v1

The FK506-binding protein FKBP52 in vitro induces aggregation of truncated Tau forms with prion-like behavior.

Julien Giustiniani , Kevin Guillemeau , Omar Dounane , Elodie Sardin , Isabelle Huvent
FASEB Journal, 2015, Epub ahead of print
Journal articles hal-01145979v1

Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy.

Benoît Gigant , Isabelle Landrieu , Caroline Fauquant , Pascale Barbier , Isabelle Huvent
Journal of the American Chemical Society, 2014, pp.12615-23
Journal articles hal-01077829v1

A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge.

Isabelle Huvent , Amina Kamah , François-Xavier Cantrelle , Nicolas Barois , Christian Slomianny
Biochemical and Biophysical Research Communications, 2014, 445 (2), pp.299-303. ⟨10.1016/j.bbrc.2014.01.161⟩
Journal articles hal-01077911v1

H/D exchange of a 15 N labelled Tau fragment as measured by a simple Relax-EXSY experiment

Juan Lopez , Puneet Ahuja , Isabelle Landrieu , Francois-Xavier Cantrelle , Isabelle Huvent
Journal of Magnetic Resonance, 2014, Journal of Magnetic Resonance, 249, pp.32-37. ⟨10.1016/j.jmr.2014.10.008⟩
Journal articles hal-03235804v1

Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2.

Gary S Mcdowell , Christopher J Hindley , Guy Lippens , Isabelle Landrieu , Anna Philpott
BMC Biochemistry, 2014, pp.24
Journal articles hal-01081937v1

Nuclear magnetic resonance analysis of the acetylation pattern of the neuronal Tau protein.

Amina Kamah , Isabelle Huvent , François-Xavier Cantrelle , Haoling Qi , Guy Lippens
Biochemistry, 2014, 53 (18), pp.3020-32. ⟨10.1021/bi500006v⟩
Journal articles hal-01077868v1

Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.

Julien Giustiniani , Béatrice Chambraud , Elodie Sardin , Omar Dounane , Kevin Guillemeau
Proceedings of the National Academy of Sciences of the United States of America, 2014, pp.4584-9
Journal articles hal-01077897v1

A new strategy for sequential assignment of intrinsically unstructured proteins based on (15)N single isotope labelling.

Juan Lopez , Puneet Ahuja , Melanie Gerard , Jean-Michel Wieruszeski , Guy Lippens
Journal of Magnetic Resonance, 2013, 236, pp.1-6. ⟨10.1016/j.jmr.2013.07.007⟩
Journal articles hal-00903369v1

Unraveling a phosphorylation event in a folded protein by NMR spectroscopy: phosphorylation of the Pin1 WW domain by PKA.

Caroline Smet-Nocca , Hélène Launay , Jean-Michel Wieruszeski , Guy Lippens , Isabelle Landrieu
Journal of Biomolecular NMR, 2013, 55 (4), pp.323-37. ⟨10.1007/s10858-013-9716-z⟩
Journal articles hal-00903359v1

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.

Kunie Ando , Pierre Dourlen , Anne-Véronique Sambo , Alexis Bretteville , Karim Bélarbi
Neurobiol Aging, 2013, 34 (3), pp.757-69. ⟨10.1016/j.neurobiolaging.2012.08.004⟩
Journal articles hal-00765859v1

Cell signaling, post-translational protein modifications and NMR spectroscopy.

Francois-Xavier Theillet , Caroline Smet-Nocca , Stamatios Liokatis , Rossukon Thongwichian , Jonas Kosten
Journal of Biomolecular NMR, 2012, 54 (3), pp.217-36. ⟨10.1007/s10858-012-9674-x⟩
Journal articles hal-00765863v1
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Differential contribution of the repeats to heparin binding of HBHA, a major adhesin of Mycobacterium tuberculosis.

Pierre Lebrun , Dominique Raze , Bernd Fritzinger , Jean-Michel Wieruszeski , Franck Biet
PLoS ONE, 2012, 7 (3), pp.e32421. ⟨10.1371/journal.pone.0032421⟩
Journal articles hal-00713026v1

Towards understanding the phosphorylation code of tau.

Guy Lippens , Laziza Amniai , Jean-Michel Wieruszeski , Alain Sillen , Arnaud Leroy
Biochemical Society Transactions, 2012, 40 (4), pp.698-703. ⟨10.1042/BST20120050⟩
Journal articles hal-00765867v1

Hepatitis C Virus NS5B and Host Cyclophilin A share a common binding site on NS5A.

Claire Rosnoblet , Bernd Fritzinger , Dominique Legrand , Hélène Launay , Jean-Michel Wieruszeski
Journal of Biological Chemistry, 2012, epub ahead of print. ⟨10.1074/jbc.M112.392209⟩
Journal articles hal-00765873v1

Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding.

Sudhakaran Prabakaran , Guy Lippens , Hanno Steen , Jeremy Gunawardena
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2012, 4 (6), pp.565-83. ⟨10.1002/wsbm.1185⟩
Journal articles hal-00765876v1

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.

Peter Borghgraef , Clément Menuet , Clara Theunis , Justin V Louis , Herman Devijver
PLoS ONE, 2012, pp.e84442
Journal articles hal-01077942v1

Mice lacking phosphatase PP2A subunit PR61/B'{delta} (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3{beta}

Justin V Louis , Ellen Martens , Peter Borghgraef , Caroline Lambrecht , Ward Sents
Proceedings of the National Academy of Sciences of the United States of America, 2011, epub ahead of print. ⟨10.1073/pnas.1018777108⟩
Journal articles hal-00586855v1
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Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands

Xavier Carette , Nicolas Blondiaux , Eve Willery , Sylviane Hoos , Nathalie Lecat-Guillet
Nucleic Acids Research, 2011, 40 (7), pp.3018 - 3030. ⟨10.1093/nar/gkr1113⟩
Journal articles pasteur-03525621v1

Systematic identification of tubulin interacting fragments of the microtubule-associated protein TAU leads to a highly efficient promoter of microtubule assembly.

Caroline Fauquant , Virginie Redeker , Isabelle Landrieu , Jean-Michel Wieruzseski , Dries Verdegem
Journal of Biological Chemistry, 2011, epub ahead of print. ⟨10.1074/jbc.M111.223545⟩
Journal articles hal-00618268v1

Domain 3 of NS5A protein from the hepatitis C virus has intrinsic {alpha}-helical propensity and is a substrate of Cyclophilin A.

Dries Verdegem , Aurelie Badillo , Jean-Michel Wieruszeski , Isabelle Landrieu , Arnaud Leroy
Journal of Biological Chemistry, 2011, epub ahead of print. ⟨10.1074/jbc.M110.182436⟩
Journal articles hal-00586923v1

Intermolecular interaction studies using small volumes.

David Bourry , Davy Sinnaeve , Katelijne Gheysen , Bernd Fritzinger , Gianni Vandenborre
Magnetic Resonance in Chemistry, 2011, 49 (1), pp.9-15. ⟨10.1002/mrc.2699⟩
Journal articles hal-00586937v1

Glycerol and glycerol carbonate as ultraviscous solvents for mixture analysis by NMR.

Pedro Lameiras , Leslie Boudesocque , Zéphirin Mouloungui , Jean-Hugues Renault , Jean-Michel Wieruszeski
Journal of Magnetic Resonance, 2011, 212 (1), pp.161-8. ⟨10.1016/j.jmr.2011.06.021⟩
Journal articles hal-00618281v1

Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.

Isabelle Landrieu , Caroline Smet-Nocca , Laziza Amniai , Justin Vijay Louis , Jean-Michel Wieruszeski
PLoS ONE, 2011, 6 (6), pp.e21521. ⟨10.1371/journal.pone.0021521⟩
Journal articles hal-00618270v1

Ranking High Affinity Ligands of Low Solubility by NMR Spectroscopy

Isabelle Landrieu , Xavier Hanoulle , Bernd Fritzinger , Dragos Horvath , Jean-Michel Wieruszeski
ACS Medicinal Chemistry Letters, 2011, 2 (6), pp.485-487. ⟨10.1021/ml200039u⟩
Journal articles hal-00618277v1

Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions.

Sudhakaran Prabakaran , Robert A Everley , Isabelle Landrieu , Jean-Michel Wieruszeski , Guy Lippens
Molecular Systems Biology, 2011, 7, pp.482. ⟨10.1038/msb.2011.15⟩
Journal articles hal-00586931v1

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.

Caroline Smet-Nocca , Malgorzata Broncel , Jean-Michel Wieruszeski , Caroline Tokarski , Xavier Hanoulle
Molecular BioSystems, 2011, 7 (5), pp.1420-9. ⟨10.1039/c0mb00337a⟩
Journal articles hal-00586849v1

Molecular Basis for an Ancient Partnership between Prolyl Isomerase Pin1 and Phosphatase Inhibitor-2.

Furqan Sami , Caroline Smet-Nocca , Meera Khan , Isabelle Landrieu , Guy Lippens
Biochemistry, 2011, 50 (30), pp.6567-78. ⟨10.1021/bi200553e⟩
Journal articles hal-00618273v1

Characterization of the AT180 epitope of phosphorylated Tau protein by a combined nuclear magnetic resonance and fluorescence spectroscopy approach.

Laziza Amniai , Guy Lippens , Isabelle Landrieu
Biochemical and Biophysical Research Communications, 2011, epub ahead of print. ⟨10.1016/j.bbrc.2011.08.046⟩
Journal articles hal-00618266v1

Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

Isabelle Landrieu , Xavier Hanoulle , Fanny Bonachera , Arnaud Hamel , Nathalie Sibille
Biochemistry, 2010, 49 (22), pp.4679-86. ⟨10.1021/bi1003266⟩
Journal articles hal-00508817v1

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.

Lotte Coelmont , Xavier Hanoulle , Udayan Chatterji , Carola Berger , Joke Snoeck
PLoS ONE, 2010, 5 (10), pp.e13687. ⟨10.1371/journal.pone.0013687⟩
Journal articles hal-00586948v1
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Microtubule and MAPs: thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR.

François Devred , Pascale Barbier , Daniel Lafitte , Isabelle Landrieu , Guy Lippens
Methods in Cell Biology, 2010, 95, pp.449-480. ⟨10.1016/S0091-679X(10)95023-1⟩
Journal articles hal-00508818v1

Spectroscopic studies of GSK3β phosphorylation of the neuronal Tau protein and its interaction with the N-terminal domain of apolipoprotein E

Arnaud Leroy , Isabelle Landrieu , Isabelle Huvent , Dominique Legrand , Bernadette Coddeville
Journal of Biological Chemistry, 2010, 285 (43), pp.33435-33444. ⟨10.1074/jbc.M110.149419⟩
Journal articles hal-00641629v1

Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.

Laziza Amniai , Pascale Barbier , Alain Sillen , Jean-Michel Wieruszeski , Vincent Peyrot
FASEB Journal, 2009, 23 (4), pp.1146-52. ⟨10.1096/fj.08-121590⟩
Journal articles hal-00348164v1

Selective backbone labelling of ILV methyl labelled proteins.

Nathalie Sibille , Xavier Hanoulle , Fanny Bonachera , Dries Verdegem , Isabelle Landrieu
Journal of Biomolecular NMR, 2009, 43 (4), pp.219-27. ⟨10.1007/s10858-009-9307-1⟩
Journal articles hal-00373458v1

Hepatitis C virus NS5A protein is a substrate for the Peptidyl-Prolyl cis/trans isomerase activity of Cyclophilins A and B.

Xavier Hanoulle , Aurélie Badillo , Jean-Michel Wieruszeski , Dries Verdegem , Isabelle Landrieu
Journal of Biological Chemistry, 2009, epub ahead of print. ⟨10.1074/jbc.M809244200⟩
Journal articles hal-00373457v1

The talin rod IBS2 alpha helix interacts with the beta 3 integrin cytoplasmic tail membrane proximal helix by establishing charge complementary salt bridges.

Sophie Rodius , Olivier Chaloin , Michèle Moes , Elisabeth Schaffner-Reckinger , Isabelle Landrieu
Journal of Biological Chemistry, 2008, epub ahead of print. ⟨10.1074/jbc.M709704200⟩
Journal articles hal-00293590v1

Sandwich-ELISE NMR: reducing the sample volume of NMR samples.

Jean-Michel Wieruszeski , Bernd Fritzinger , Xavier Hanoulle , José C Martins , Guy Lippens
Journal of Magnetic Resonance, 2008, 193 (1), pp.37-40. ⟨10.1016/j.jmr.2008.04.006⟩
Journal articles hal-00293593v1

Contribution of rotational diffusion to pulsed field gradient diffusion measurements.

Andrew J Baldwin , John Christodoulou , Paul D Barker , Christopher M Dobson , Guy Lippens
Journal of Chemical Physics, 2007, 127 (11), pp.114505. ⟨10.1063/1.2759211⟩
Journal articles hal-00273334v1

Tau aggregation in Alzheimer's disease : what role for phosphorylation ?

Guy Lippens , Alain Sillen , Isabelle Landrieu , Laziza Amniai , Nathalie Sibille
Prion, 2007, 1 (1), pp.21-25
Journal articles hal-00161158v1

Structural and functional characterisation of the interaction between cyclophilin B and A heparin derived oligosaccharide.

Xavier Hanoulle , Aurélie Melchior , Nathalie Sibille , Benjamin Parent , Agnès Denys
Journal of Biological Chemistry, 2007, epub ahead of print. ⟨10.1074/jbc.M706353200⟩
Journal articles hal-00175485v1

NMR Investigation of the Interaction between the Neuronal Protein Tau and the Microtubules.

Alain Sillen , Pascale Barbier , Isabelle Landrieu , Sylvie Lefebvre , Jean-Michel Wieruszeski
Biochemistry, 2007, 46 (11), pp.3055-3064. ⟨10.1021/bi061920i⟩
Journal articles hal-00139673v1

Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy.

Guy Lippens , Alain Sillen , Caroline Smet , Jean-Michel Wieruszeski , Arnaud Leroy
Protein and Peptide Letters, 2006, 13, pp.235-246
Journal articles hal-00085628v1

Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A.

Marco da Costa , Liên Bach , Isabelle Landrieu , Yannick Bellec , Olivier Catrice
The Plant cell, 2006, 18, pp.1426-1437
Journal articles hal-00085654v1

New DEFT sequences for the acquisition of one-dimensional carbon NMR spectra of small unlabelled molecules.

Guy Lippens , Jean-Michel Wieruszeski , Marcel Piotto , Karim Elbayed , Marise Bourdonneau
Magnetic Resonance in Chemistry, 2006, 44, pp.943-947
Journal articles hal-00103769v1

Exploring the Molecular Function of PIN1 by Nuclear Magnetic Resonance.

Isabelle Landrieu , Caroline Smet , Jean-Michel Wieruszeski , Anne-Véronique Sambo , René Wintjens
Current Protein and Peptide Science, 2006, 7, pp.179-194
Journal articles hal-00085621v1

Pin1 allows for differential Tau dephosphorylation in neuronal cells.

Malika Hamdane , Pierre Dourlen , Alexis Bretteville , Anne-Véronique Sambo , Stéphanie Ferreira
Molecular and Cellular Neuroscience, 2006, 32, pp.155-160
Journal articles hal-00085645v1

Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria.

Xavier Hanoulle , Jean-Michel Wieruszeski , Pierre Rousselot-Pailley , Isabelle Landrieu , Camille Locht
Journal of Antimicrobial Chemotherapy, 2006, 58 (4), pp.768. ⟨10.1093/jac/dkl332⟩
Journal articles hal-00103724v1

Osmoregulated periplasmic glucans of the free-living photosynthetic bacterium Rhodobacter sphaeroides

Philippe Talaga , Virginie Cogez , Jean-Michel Wieruszeski , Bernd Stahl , Jérôme Lemoine
European Journal of Biochemistry, 2002, 269, pp.2464-2472
Journal articles hal-00021144v1

In vivo detection of the cyclic osmoregulated periplasmic glucan of Ralstonia solanacearum by high-resolution magic angle spinning NMR.

Jean-Michel Wieruszeski , Anne Bohin , Jean-Pierre Bohin , Guy Lippens
Journal of Magnetic Resonance, 2001, 151, pp.1-6
Journal articles hal-00021378v1

Recombinant production of the p10CKS1At protein from Arabidopsis thaliana and 13C and 15N double-isotopic enrichment for NMR studies

I. Landrieu , P. Casteels , B. Odaert , Lieven de Veylder , D. Portetelle
Protein Expression and Purification, 1999, 16, pp.144-151
Journal articles hal-02686867v1