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Haoues Alout

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Haoues ALOUT Born on Nov. 6th 1980 French Tel: +33 4 67 61 49 99 Email: <haoues.alout@inrae.fr> ; haoues.alout@cirad.fr **Professional status** May 2018 – present **Research Scientist** at the Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (INRAE), ASTRE lab (Animal-Santé-Territoires-Risques-Ecosystèmes) CIRAD/INRAE. May 2017 – April 2018 Marie Skłodowska-Curie Postdoctoral Fellowship at the Institute of Evolutionary Sciences Montpellier (ISEM). IRWIC project, grant agreement number 74989. Dec. 2013 – Feb. 2016 Research Scientist at the Arthropod-borne and Infectious Disease Laboratory, Colorado State University (AIDL). Dec. 2012 – Nov. 2013 Postdoctoral position at the AIDL, Colorado State University Oct. 2010 – Oct. 2012 Postdoctoral Fellow at the Institut de Recherche pour le Développement (IRD) and the Institut de Recherche en Science de la Santé (IRSS, Burkina Faso). June /July 2009 Volunteer at the Tsaobis Baboon Project, Namibia. University of Montpellier, FR and Zoological Society of London, UK. 2005 - 2006 Development engineer at the Genetic of Adaptation lab (ISEM) and the Center of Research on Macromolecular Biochemistry – Montpellier. **Diploma and awards** January 2009 **Ph.D. in Evolutionary biology**. Genetic of adaptation Laboratory. Institute of Evolutionary Sciences Montpellier (ISEM), University of Montpellier 2. 2007 Prize for the best student poster in the IXth International Meeting on Cholinesterases, Suzhou, China. 2003 - 2004 Dîplome d’Etudes Supérieures Spécialisées (equivalent to master’s degree) in Biotechnology. University of Montpellier 1 and 2. 2002 - 2003 Postgraduate in Biochemistry at the University P. and M. Curie, Paris VI (France). Institute of Biomedical and Biomolecular Science. University of Portsmouth (UK). **teaching and mentoring** 2019 – 2020 Teaching Master 2 (Gestion Intégrée des Maladies Animales Tropicales) at the National Veterinary School of Toulouse in Ecology and integrated vector control 2015 – 2019 Teaching Master 1 (Biodiversité Écologie Évolution) students in Vector biology, ecology and control. University of Montpellier. 2015 Training in Good clinical practices and Research ethics. RIMDAMAL project, Burkina Faso. (ClinicalTrial : [NCT02509481](https://clinicaltrials.gov/ct2/show/NCT02509481?term=ivermectin+malaria+foy&rank=1)). 2006 - 2014 Mentoring master students in biochemistry (France), parasitology (Burkina Faso) and vector biology (Benin, Madagascar) 2005 Training vector control operators in Detection and Analysis of Insecticide Resistance in mosquito. (Université de Monastir, Tunisia) **Funding** 2021 – 2024 ANR - Genetic architectures of insecticide resistance: from genomics to vectorial capacity – ArchR (role: Co-Investigateur, ANR-20-CE34-0007) 2017 - 2019 Marie Skłodowska-Curie Fellowship. Influence of Insecticide Resistance, Wolbachia and their Interaction on Chikungunya transmission - IRWIC (agreement n°749897) 2015 - 2016 GCE round 14. Bill and Melinda Gates Foundation. Project: Dry-to-rainy season integrated control of NTDs and malaria (role: Co-Investigateur, BMGF:01818000168). 2010 – 2012 IRD Postdoctoral Fellowship (2010). Project: Impact of Insecticide Reistance on Malaria Transmission (Burkina Faso). 2006 – 2008 ANR (french national research agency) Evolution and managing insecticide resistance in mosquitoes – MOREVOL **Expertise** Reviewer for Insect Molecular Biology (1), Biologia (1), Journal of Economical Entomology (1), Journal of Medical Entomology (1), Pesticide Biochemistry and Physiology (2), Insect Biochemistry and Molecular Biology (7), Comparative Biochemistry and Molecular Biology (1), Pest Management Science (1), PLoS Neglected Tropical Diseases (2), PLoS One (1), BMC Infectious Diseases (1), EcoHealth (1), Journal of Medicinal Chemistry (1), Evolutionary Applications (3) et Lancet Infectious Diseases (1) Referee for funding agencies: ANR (Agence Nationale de la Recherche), ANSES, MRC (Medical Research Council), Crick African Network and Marie Skłodowska-Curie Fellowship. Expert for the French Agency for Food, Environmental and Occupational Health &amp; Safety (ANSES): member of the “Insecticide resistance in mosquito vectors” working group (2020-2022) **PoPULAR PRESS** Midi Libre. Les Poux font de la résistance (sept 25th 2016). <http://www.midilibre.fr/2016/09/24/les-poux-font-de-la-resistance,1398418.php> Forbes. Nobel Prize-Winning Drug Ivermectin May Fight Malaria (oct 27th 2015). <https://www.forbes.com/sites/judystone/2015/10/27/nobel-prize-winning-drug-ivermectin-may-fight-malaria/#2c321e8a6026> Science Magazine. Drug could kill mosquitoes when they feast on human blood (oct 27th 2015). <http://www.sciencemag.org/news/2015/10/drug-could-kill-mosquitoes-when-they-feast-human-blood> Collegian Central. Colorado State researchers study malaria prevention (nov. 11th 2014). <http://collegian.com/2014/11/colorado-state-researchers-study-malaria-prevention/101215/> Source. Researcher: Fight malaria with deadly mosquito meals (nov. 5th 2014). <http://source.colostate.edu/researcher-fight-malaria-deadly-mosquito-meals/>

Publications

Fitness costs associated with a GABA receptor mutation conferring dieldrin resistance in Aedes albopictus

Yann Gomard , Haoues Alout , Cyrille Lebon , Anne Latreille , Aude Benlali et al.
Heredity, 2022, 129 (5), pp.273-280. ⟨10.1038/s41437-022-00565-7⟩
Journal articles hal-03835334v1
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The ecological significance of arthropod vectors of plant, animal, and human pathogens

Thierry Lefèvre , Nicolas Sauvion , Rodrigo P.P. Almeida , Florence Fournet , Haoues Alout et al.
Trends in Parasitology, 2022, 38 (5), pp.404-418. ⟨10.1016/j.pt.2022.01.004⟩
Journal articles hal-03615705v1
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Spatio-Temporal Dynamics of a Dieldrin Resistance Gene in Aedes albopictus and Culex quinquefasciatus Populations From Reunion Island

Cyrille Lebon , Haoues Alout , Stanislas Zafihita , Jean-Sébastien Dehecq , Mylène Weill et al.
Journal of Insect Science, 2022, 22 (3), ⟨10.1093/jisesa/ieac023⟩
Journal articles hal-03689388v1
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What evidence exists on the impact of specific ecosystem components and functions on infectious diseases? A systematic map

Léa Lugassy , Ludivine Amdouni-Boursier , Haoues Alout , Romuald Berrebi , Christophe Boëte et al.
Environmental Evidence, 2021, 10 (1), pp.11. ⟨10.1186/s13750-021-00220-4⟩
Journal articles hal-03279595v1
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Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study

Hannah C. Slater , Brian D. Foy , Kevin Kobylinski , Carlos Chaccour , Oliver J. Watson et al.
The Lancet Infectious Diseases, 2020, 20 (4), pp.498-508. ⟨10.1016/S1473-3099(19)30633-4⟩
Journal articles hal-02450316v1
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Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals

Chilinh Nguyen , Meg Gray , Timothy A. Burton , Soleil L. Foy , John R. Foster et al.
PLoS Neglected Tropical Diseases, 2019, 13 (3), pp.e0007210. ⟨10.1371/journal.pntd.0007210⟩
Journal articles hal-02626865v1
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Insecticide resistance genes affect Culex quinquefasciatus vector competence for West Nile virus

Célestine Atyame Nten , Haoues Alout , Laurence Mousson , Marie Vazeille , Mawlouth Diallo et al.
Proceedings of the Royal Society B: Biological Sciences, 2019, 286 (1894), pp.20182273. ⟨10.1098/rspb.2018.2273⟩
Journal articles pasteur-02098394v1
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What is the evidence that ecosystem components or functions have an impact on infectious diseases? A systematic review protocol

Léa Lugassy , Ludivine Amdouni-Boursier , Haoues Alout , Romuald Berrebi , Christophe Boëte et al.
Environmental Evidence, 2019, 8 (4), 11 p. ⟨10.1186/s13750-019-0147-5⟩
Journal articles hal-02617792v1
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Differential Susceptibility and Innate Immune Response of Aedes aegypti and Aedes albopictus to the Haitian Strain of the Mayaro Virus

Fode Diop , Haoues Alout , Cheikh Tidiane Diagne , Michèle Bengue , Cecile Baronti et al.
Viruses, 2019, 11 (10), pp.924. ⟨10.3390/v11100924⟩
Journal articles hal-02396716v1
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Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial

Brian Foy , Haoues Alout , Jonathan Seaman , Sangeeta Rao , Tereza Magalhaes et al.
The Lancet, 2019, 393 (10180), pp.1517-1526. ⟨10.1016/S0140-6736(18)32321-3⟩
Journal articles hal-02434760v1
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Innate immune response of primary human keratinocytes to West Nile virus infection and its modulation by mosquito maliva

Magali Garcia , Haoues Alout , Fode Diop , Alexia Damour , Michèle Bengue et al.
Frontiers in Cellular and Infection Microbiology, 2018, 8, pp.387. ⟨10.3389/fcimb.2018.00387⟩
Journal articles hal-01921855v1
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Adaptive deletion in resistance gene duplications in the malaria vector Anopheles gambiae

Benoît S Assogba , Haoues Alout , Alphonsine Koffi , Cédric Penetier , Luc Djogbénou et al.
Evolutionary Applications, 2018, 11 (8), pp.1245-1256. ⟨10.1111/eva.12619⟩
Journal articles hal-01914795v1

Ivermectin: a complimentary weapon against the spread of malaria?

Haoues Alout , Brian Foy
Expert Review of Anti-infective Therapy, 2017, 15 (3), pp.231-240. ⟨10.1080/14787210.2017.1271713⟩
Journal articles hal-01944453v1
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Analysis of near infrared spectra for age-grading of wild populations of Anopheles gambiae

Benjamin Krajacich , Jacob Meyers , Haoues Alout , Roch Dabiré , Floyd Dowell et al.
Parasites & Vectors, 2017, 10 (1), ⟨10.1186/s13071-017-2501-1⟩
Journal articles hal-01944438v1

Ivermectin: a complimentary weapon against the spread of malaria?

Haoues Alout , Brian D. Foy
Expert Review of Anti-infective Therapy, 2017, 15 (3), pp.231-240. ⟨10.1080/14787210.2017.1271713⟩
Journal articles hal-02625607v1

Malaria Vector Control Still Matters despite Insecticide Resistance

Haoues Alout , Pierrick Labbe , Fabrice Chandre , Anna Cohuet
Trends in Parasitology, 2017, 33 (8), pp.610 - 618. ⟨10.1016/j.pt.2017.04.006⟩
Journal articles hal-01938020v1
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Consequences of insecticide resistance on malaria transmission

Haoues Alout , Benjamin Roche , Roch Kounbobr Dabiré , Anna Cohuet
PLoS Pathogens, 2017, 13 (9), pp.e1006499. ⟨10.1371/journal.ppat.1006499⟩
Journal articles hal-01942723v1
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Analysis of near infrared spectra for age-grading of wild populations of Anopheles gambiae

Benjamin J. Krajacich , Jacob I. Meyers , Haoues Alout , Roch K. Dabiré , Floyd E. Dowell et al.
Parasites & Vectors, 2017, 10 (1), ⟨10.1186/s13071-017-2501-1⟩
Journal articles hal-02619983v1
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High chlorpyrifos resistance in Culex pipiens mosquitoes: strong synergy between resistance genes

Haoues Alout , Pierrick Labbé , A Berthomieu , Patrick Makoundou , Philippe Fort et al.
Heredity, 2016, 116 (2), pp.224-231. ⟨10.1038/hdy.2015.92⟩
Journal articles hal-01944470v1
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Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae

Haoues Alout , Roch Dabiré , Luc Djogbénou , Luc Abate , Vincent Corbel et al.
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep29755⟩
Journal articles hal-01944457v1

Sampling host-seeking anthropophilic mosquito vectors in West Africa: Comparisons of an active human-baited tent-trap against gold standard methods

Benjamin J. Krajacich , Brendan Labrecque , Lawrence S. Fakoli , Joseph W. Diclaro , Brian D. Foy et al.
American Journal of Tropical Medicine and Hygiene, 2015, 92 (2), pp.415-421. ⟨10.4269/ajtmh.14-0303⟩
Journal articles hal-02630660v1
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Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals

Jonathan A. Seaman , Haoues Alout , Jacob I. Meyers , Mark D. Stenglein , Roch K. Dabiré et al.
BMC Genomics, 2015, 16, ⟨10.1186/s12864-015-2029-8⟩
Journal articles hal-02632006v1

Interplay between Plasmodium infection and resistance to insecticides in vector mosquitoes

Haoues Alout , Bienvenue Yameogo , Luc Salako Djogbenou , Fabrice Chandre , Roch Kounbobr Dabiré et al.
Journal of Infectious Diseases, 2014, 210 (9), pp.1464-1470. ⟨10.1093/infdis/jiu276⟩
Journal articles hal-02641602v1

Insecticide exposure impacts vector-parasite interactions in insecticide-resistant malaria vectors

Haoues Alout , Innocent Djègbé , Fabrice Chandre , Luc Salako Djogbenou , Roch Kounbobr Dabiré et al.
Proceedings of the Royal Society B: Biological Sciences, 2014, 281 (1786), ⟨10.1098/rspb.2014.0389⟩
Journal articles hal-02641601v1
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Evaluation of ivermectin mass drug administration for malaria transmission control across different West African environments

Haoues Alout , Benjamin J. Krajacich , Jacob I. Meyers , Nathan D. Grubaugh , Doug E. Brackney et al.
Malaria Journal, 2014, 13 (1), 10 p. ⟨10.1186/1475-2875-13-417⟩
Journal articles hal-02631695v1

Rationale for the coadministration of albendazole and ivermectin to humans for malaria parasite transmission control

Kevin C. Kobylinski , Haoues Alout , Brian D. Foy , Archie Clements , Poom Adisakwattana et al.
American Journal of Tropical Medicine and Hygiene, 2014, 91 (4), pp.655-662. ⟨10.4269/ajtmh.14-0187⟩
Journal articles hal-02631850v1
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Insecticide resistance alleles affect vector competence of Anopheles gambiae s.s. for Plasmodium falciparum field isolates

Haoues Alout , Nicaise Tuikue Ndam , Marcel Maurice Sandeu , Innocent Djègbé , Fabrice Chandre et al.
PLoS ONE, 2013, 8 (5), pp.e63849. ⟨10.1371/journal.pone.0063849⟩
Journal articles hal-02653010v1
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Novel AChE Inhibitors for Sustainable Insecticide Resistance Management

Haoues Alout , Pierrick Labbe , Arnaud Berthomieu , Luc Djogbénou , Jean-Paul Leonetti et al.
PLoS ONE, 2012, 7 (10), pp.e47125. ⟨10.1371/journal.pone.0047125⟩
Journal articles hal-01938151v1
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High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from Algeria

Haoues Alout , Pierrick Labbé , Nicole Pasteur , Mylène Weill
Insect Biochemistry and Molecular Biology, 2011, 41 (1), pp.29-35. ⟨10.1016/j.ibmb.2010.09.009⟩
Journal articles halsde-00633660v1

Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réunion Island

Michaël Luciano Tantely , Pablo Tortosa , Haoues Alout , Claire Berticat , Arnaud Berthomieu et al.
Insect Biochemistry and Molecular Biology, 2010, 40 (4), pp.317--324. ⟨10.1016/j.ibmb.2010.02.005⟩
Journal articles hal-01274621v1
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Acetylcholinesterase point mutations in European strains of Tetranychus urticae (Acari: Tetranychidae) resistant to organophosphates

Jahangir Khajehali , Thomas van Leeuwen , Maria Grispou , Evangelia Morou , Haoues Alout et al.
Pest Management Science, 2009, 66 (2), pp.n/a-n/a. ⟨10.1002/ps.1884⟩
Journal articles hal-01944635v1

Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populations

Haoues Alout , Pierrick Labbe , Arnaud Berthomieu , Nicole Pasteur , Mylène Weill et al.
Insect Biochemistry and Molecular Biology, 2009, 39 (12), pp.884 - 891. ⟨10.1016/j.ibmb.2009.10.005⟩
Journal articles hal-01938164v1
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Comparison of Anopheles gambiae and Culex pipiens acetycholinesterase 1 biochemical properties

Haoues Alout , Luc Djogbénou , Claire Berticat , Fabrice Chandre , Mylène Weill et al.
Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 2008, 150 (3), pp.271-277. ⟨10.1016/j.cbpb.2008.03.008⟩
Journal articles halsde-00454638v1
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Evidence of Introgression of the ace-1R Mutation and of the ace-1 Duplication in West African Anopheles gambiae s. s.

Luc Djogbénou , Fabrice Chandre , Arnaud Berthomieu , Roch Dabiré , Alphonsine Koffi et al.
PLoS ONE, 2008, 3 (5), pp.e2172. ⟨10.1371/journal.pone.0002172⟩
Journal articles halsde-00527414v1
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Amino-acid substitutions in acetylcholinesterase 1 involved in insecticide resistance in mosquitoes

Haoues Alout , Mylène Weill
Chemico-Biological Interactions, 2008, 175 (1-3, sp. Issue), pp.138-141. ⟨10.1016/j.cbi.2008.03.018⟩
Journal articles halsde-00454646v1

A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipiens mosquitoes from Cyprus

Haoues Alout , Arnaud Berthomieu , Andreas Andreas Hadjivassilis , Mylène Weill
Insect Biochemistry and Molecular Biology, 2007, 37 (1), pp.41-47. ⟨10.1016/j.ibmb.2006.10.001⟩
Journal articles halsde-00367134v1
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Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiens

Pierrick Labbé , Arnaud Berthomieu , Claire Berticat , Haoues Alout , Michel Raymond et al.
Molecular Biology and Evolution, 2007, 24 (4), pp.1056-1067. ⟨10.1093/molbev/msm025⟩
Journal articles halsde-00186494v1

Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 insensitivity in Culex vishnui and Culex tritaeniorhynchus (Diptera: Culicidae) from China.

Haoues Alout , Arnaud Berthomieu , Feng Cui , Yi Tan , Claire Berticat et al.
Journal of Medical Entomology, 2007, 44 (3), pp.463-9. ⟨10.1093/jmedent/44.3.463⟩
Journal articles hal-01945512v1
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Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae).

Feng Cui , Michel Raymond , Arnaud Berthomieu , Haoues Alout , Mylene Weill et al.
Journal of Medical Entomology, 2006, 43 (5), pp.878-83. ⟨10.1093/jmedent/43.5.878⟩
Journal articles hal-01945532v1
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Acetylcholinesterase genes within the Diptera: takeover and loss in true flies

Elise Huchard , Michel Martinez , Haoues Alout , Emmanuel J.P. Douzery , Georges Lutfalla et al.
Proceedings of the Royal Society B: Biological Sciences, 2006, 273 (1601), pp.2595-2604. ⟨10.1098/rspb.2006.3621⟩
Journal articles hal-01945529v1
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Is malaria vector control still useful despite insecticide resistance?

Haoues Alout
2018 Institut Pasteur International Network Symposium, Nov 2018, Paris, France
Conference papers hal-02788777v1
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Is vector control still useful despite insecticide resistance?

Haoues Alout
Journées d'Animation Scientifique du Département Santé Animale, Oct 2018, Nantes, France
Conference papers hal-02788925v1
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Insecticide resistance modulates densovirus effect in Aedes albopictus

Haoues Alout , Alice Namias , Pierrick Labbé , Célestine Atyame Nten , Pablo Tortosa et al.
EMBO conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: Current, Resurgent and Emerging Diseases, Jul 2019, Kolymbari, Greece. 2019
Conference poster hal-02790906v1
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Age-dependent susceptiblility to ivermectin and gene expression following an ivermectin blood meal in the malaria vector Anopheles gambiae

Haoues Alout
EMBO conference on Molecular and Population Biology of Mosquitoes and Other Disease Vectors: Current, Resurgent and Emerging Diseases, Jul 2015, Kolymbari, Greece. 2017
Conference poster hal-02785632v1
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Evolution of resistance to insecticide in disease vectors

Pierrick Labbé , Jean-Philippe David , Haoues Alout , Pascal Milesi , Nicole Pasteur et al.
Genetics and evolution of infectious diseases, Academic press, Elsevier, 2017, 9780127999425. ⟨10.1016/B978-0-12-799942-5.00014-7⟩
Book sections hal-02786153v1
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Evolution of resistance to insecticide in disease vectors

Pierrick Labbe , Haoues Alout , Luc Djogbénou , Nicole Pasteur , Mylène Weill et al.
Genetics and Evolution of Infectious Disease, Elsevier, Academic Press, 2011, 9780123848901. ⟨10.1016/B978-0-12-384890-1.00014-5⟩
Book sections hal-02805959v1