Harald Hampel

107
Documents

Présentation

Professor Harald Hampel obtained his MD and PhD at the University of Munich, Germany. After training at the University of Munich, he moved to Washington D.C. in 1995 for a post-doctoral fellowship at the National Institutes of Health (NIH), National Institute on Aging (NIA), Laboratory of Neurosciences in Bethesda, Md., USA, focusing on structural & functional neuroimaging of the healthy aging and Alzheimer's disease brain. In 1997 he became founding director of the Alzheimer Memorial Center at the University of Munich where he was appointed as Professor of Psychiatry in 2005. In 2006 he moved to Dublin and was appointed Professor and Chair of Psychiatry at Trinity College, University of Dublin, Ireland. During this time, he was a PI at the Trinity College Institute of Neuroscience (TCIN). In 2010 he was appointed Professor, Chair and Head of Department of Psychiatry, head of the Alzheimer Research Center and co-director of the Brain Imaging Center (BIC) at the University of Frankfurt, Germany. In 2013-2019 he was appointed Professor and AXA Research Fund & Sorbonne University Excellence Chair at Sorbonne University, Institut de la Mémoire et de la Maladie d’Alzheimer (IM2A), Institut du Cerveau et de la Moelle épinière (ICM), at the Department of Neurology, Hôpital Pitié Salpêtrière in Paris, France.

Professor Hampel was coordinator of major clinical and translational research programs, in the area of Alzheimer's and other neurodegenerative diseases.
In 2019 he joined Eisai Inc. and became Chief Medical Officer, Senior Vice President, Head of Global Medical Affairs, Neurology Business Group, Nutley, NJ, USA.

He is founding president of the Alzheimer Precision Medicine Initiative (APMI) and its cohort program (APMI-CP) and heads the international Cholinergic Systems Working Group.

https://www.linkedin.com/in/harald-hampel-md-phd-msc-7496357b/

https://orcid.org/0000-0003-0894-8982

Publications

Publications

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The foundation and architecture of precision medicine in neurology and psychiatry

Harald Hampel , Peng Gao , Jeffrey Cummings , Nicola Toschi , Paul M Thompson et al.
Trends in Neurosciences, In press, ⟨10.1016/j.tins.2022.12.004⟩
Article dans une revue hal-03938895 v1

Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Itziar de Rojas , Sonia Moreno-Grau , Niccolo Tesi , Benjamin Grenier-Boley , Victor Andrade et al.
Nature Communications, 2023, 14 (1), pp.716. ⟨10.1038/s41467-023-36192-x⟩
Article dans une revue hal-04028789 v1
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Differential response to donepezil in MRI subtypes of mild cognitive impairment

Patricia Diaz-Galvan , Giulia Lorenzon , Rosaleena Mohanty , Gustav Mårtensson , Enrica Cavedo et al.
Alzheimer's Research and Therapy, 2023, 15 (1), pp.117. ⟨10.1186/s13195-023-01253-2⟩
Article dans une revue hal-04506131 v1
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Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Yann Le Guen , Guo Luo , Aditya Ambati , Vincent Damotte , Iris Jansen et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (36), ⟨10.1073/pnas.2302720120⟩
Article dans une revue hal-04277835 v1
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State‐of‐the‐art of lumbar puncture and its place in the journey of patients with Alzheimer's disease

Harald Hampel , Leslie M Shaw , Paul Aisen , Christopher Chen , Alberto Lleó et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022, 18 (1), pp.159-177. ⟨10.1002/alz.12372⟩
Article dans une revue (article de synthèse) hal-03942259 v1
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Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

Iris E. Jansen , Sven J van der Lee , Duber Gomez-Fonseca , Itziar de Rojas , Maria Carolina Dalmasso et al.
Acta Neuropathologica, 2022, 144 (5), pp.821-842. ⟨10.1007/s00401-022-02454-z⟩
Article dans une revue hal-03902957 v1
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Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease

Herman Depypere , Andrea Vergallo , Pablo Lemercier , Simone Lista , Andrea Benedet et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022, ⟨10.1002/alz.12759⟩
Article dans une revue (data paper) hal-03942258 v1
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Designing the next-generation clinical care pathway for Alzheimer’s disease

Harald Hampel , Rhoda Au , Soeren Mattke , Wiesje M van der Flier , Paul Aisen et al.
Nature Aging, 2022, 2, 2, pp.692 - 703. ⟨10.1038/s43587-022-00269-x⟩
Article dans une revue hal-03942256 v1
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New insights into the genetic etiology of Alzheimer's disease and related dementias

Celine Bellenguez , Fahri Kucukali , Iris E. Jansen , Luca Kleineidam , Sonia Moreno-Grau et al.
Nature Genetics, 2022, 54 (4), pp.412-436. ⟨10.1038/s41588-022-01024-z⟩
Article dans une revue hal-03668928 v1
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Evaluation of major national dementia policies and health‐care system preparedness for early medical action and implementation

Harald Hampel , Andrea Vergallo , Takeshi Iwatsubo , Min Cho , Kiyoshi Kurokawa et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022, 18 (10), pp.1993-2002. ⟨10.1002/alz.12655⟩
Article dans une revue (article de synthèse) hal-03942260 v1

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

Olin Janssen , Stephanie Vos , Rik Ossenkoppele , Pieter Jelle Visser , Dag Aarsland et al.
JAMA neurology, 2022, 79 (3), pp.228. ⟨10.1001/jamaneurol.2021.5216⟩
Article dans une revue hal-04446257 v1
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Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer’s disease

Harald Hampel , Andrea Vergallo , Mohammad Afshar , Leyla Akman-Anderson , Joaquín Arenas et al.
Dialogues in Clinical Neuroscience, 2022, 21, pp.177 - 191. ⟨10.31887/dcns.2019.21.2/hhampel⟩
Article dans une revue hal-04496053 v1
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Aptamarker prediction of brain amyloid-β status in cognitively normal individuals at risk for Alzheimer’s disease

Gregory Penner , Soizic Lecocq , Anaëlle Chopin , Ximena Vedoya , Simone Lista et al.
PLoS ONE, 2021, 16 (1), pp.e0243902. ⟨10.1371/journal.pone.0243902⟩
Article dans une revue hal-03212567 v1
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MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints

Andrea Vergallo , Simone Lista , Yuhai Zhao , Pablo Lemercier , Stefan Teipel et al.
Translational Psychiatry, 2021, 11 (1), pp.78. ⟨10.1038/s41398-020-01184-8⟩
Article dans une revue hal-03125818 v1
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The Amyloid-β Pathway in Alzheimer’s Disease

Harald Hampel , John Hardy , Kaj Blennow , Christopher Chen , George Perry et al.
Molecular Psychiatry, 2021, 26, pp.5481 - 5503. ⟨10.1038/s41380-021-01249-0⟩
Article dans une revue (article de synthèse) hal-03942257 v1

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas , Sonia Moreno-Grau , Niccolo Tesi , Benjamin Grenier-Boley , Victor Andrade et al.
Nature Communications, 2021, 12 (1), pp.3417. ⟨10.1038/s41467-021-22491-8⟩
Article dans une revue hal-04278002 v1
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The β-Secretase BACE1 in Alzheimer’s Disease

Harald Hampel , Robert Vassar , Bart de Strooper , John Hardy , Michael Willem et al.
Biological Psychiatry, 2021, 89 (8), pp.745-756. ⟨10.1016/j.biopsych.2020.02.001⟩
Article dans une revue hal-03197728 v1
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Plasma β‐secretase1 concentrations correlate with basal forebrain atrophy and neurodegeneration in cognitively healthy individuals at risk for AD

Andrea Vergallo , Pablo Lemercier , Enrica Cavedo , Simone Lista , Eugeen Vanmechelen et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, 17 (4), pp.629-640. ⟨10.1002/alz.12228⟩
Article dans une revue hal-03769571 v1
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Association of plasma Aβ40/Aβ42 ratio and brain Aβ accumulation: testing a whole-brain PLS-VIP approach in individuals at risk of Alzheimer's disease

Pablo Lemercier , Andrea Vergallo , Simone Lista , Henrik Zetterberg , Kaj Blennow et al.
Neurobiology of Aging, 2021, 107, pp.57 - 69. ⟨10.1016/j.neurobiolaging.2021.07.005⟩
Article dans une revue hal-03391168 v1
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Progress regarding the context-of-use of tau as biomarker of Alzheimer’s disease and other neurodegenerative diseases

Nicole Campese , Giovanni Palermo , Claudia Del Gamba , Maria Francesca Beatino , Alessandro Galgani et al.
Expert Review of Proteomics, 2021, ⟨10.1080/14789450.2021.1886929⟩
Article dans une revue hal-03138524 v1
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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Itziar de Rojas , Sonia Moreno-Grau , Niccolo Tesi , Benjamin Grenier-Boley , Victor Andrade et al.
Nature Communications, 2021, 12 (1), pp.3417. ⟨10.1038/s41467-021-22491-8⟩
Article dans une revue hal-03287265 v1
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Future avenues for Alzheimer's disease detection and therapy: liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery

Harald Hampel , Andrea Vergallo , Filippo Caraci , A. Claudio Cuello , Pablo Lemercier et al.
Neuropharmacology, 2021, 185, pp.108081. ⟨10.1016/j.neuropharm.2020.108081⟩
Article dans une revue hal-04494265 v1
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Characteristics of subjective cognitive decline associated with amyloid positivity

Olin Janssen , Willemijn J Jansen , Stephanie Vos , Merce Boada , Lucilla Parnetti et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2021, 18 (10), pp.1832-1845. ⟨10.1002/alz.12512⟩
Article dans une revue hal-04524946 v1
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Partial Volume Correction Increases the Sensitivity of 18F-Florbetapir-Positron Emission Tomography for the Detection of Early Stage Amyloidosis

Stefan J Teipel , Martin Dyrba , Andrea Vergallo , Simone Lista , Marie Odile Habert et al.
Frontiers in Aging Neuroscience, 2021, 13, ⟨10.3389/fnagi.2021.748198⟩
Article dans une revue hal-03521540 v1
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β-Secretase1 biological markers for Alzheimer’s disease: state-of-art of validation and qualification

Harald Hampel , Simone Lista , Eugeen Vanmechelen , Henrik Zetterberg , Filippo Sean Giorgi et al.
Alzheimer's Research and Therapy, 2020, 12 (1), pp.130. ⟨10.1186/s13195-020-00686-3⟩
Article dans une revue hal-03769540 v1
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Accuracy of MRI Classification Algorithms in a Tertiary Memory Center Clinical Routine Cohort

Alexandre Morin , Jorge Samper-González , Anne Bertrand , Sebastian Ströer , Didier Dormont et al.
Journal of Alzheimer's Disease, 2020, pp.1-10. ⟨10.3233/JAD-190594⟩
Article dans une revue hal-02511532 v1
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Rationale for Early Diagnosis of Mild Cognitive Impairment (MCI) supported by Emerging Digital Technologies

Marwan N Sabbagh , M. Boada , S. Borson , M. Chilukuri , P.M. Doraiswamy et al.
The Journal of prevention of Alzheimer's disease, 2020, 7, pp.158-164. ⟨10.14283/jpad.2020.19⟩
Article dans une revue hal-04549252 v1
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Early Detection of Mild Cognitive Impairment (MCI) in an At-Home Setting

Marwan N Sabbagh , M. Boada , S. Borson , P. M. Doraiswamy , B. Dubois et al.
The Journal of prevention of Alzheimer's disease, 2020, 7, pp.171-178. ⟨10.14283/jpad.2020.22⟩
Article dans une revue hal-04549431 v1
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Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

Claudio Babiloni , Susanna Lopez , Claudio del Percio , Giuseppe Noce , Maria Teresa Pascarelli et al.
Neurobiology of Aging, 2020, 90, pp.43-59. ⟨10.1016/j.neurobiolaging.2020.01.012⟩
Article dans une revue hal-03006214 v1

In vivo staging of regional amyloid deposition predicts functional conversion in the preclinical and prodromal phases of Alzheimer's disease

Stefan Teipel , Martin Dyrba , Patrizia Chiesa , Fatemah Sakr , Irina Jelistratova et al.
Neurobiology of Aging, 2020, 93, pp.98-108. ⟨10.1016/j.neurobiolaging.2020.03.011⟩
Article dans une revue hal-03769731 v1
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Age and sex impact plasma NFL and t-Tau trajectories in individuals with subjective memory complaints: a 3-year follow-up study

Filippo Baldacci , Simone Lista , Maria Laura Manca , Patrizia A Chiesa , Enrica Cavedo et al.
Alzheimer's Research and Therapy, 2020, 12 (1), pp.147. ⟨10.1186/s13195-020-00704-4⟩
Article dans une revue hal-03272059 v1
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Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers

Andrea Vergallo , Simone Lista , Pablo Lemercier , Patrizia A. Chiesa , Henrik Zetterberg et al.
Neurobiology of Aging, 2020, 96, pp.22-32. ⟨10.1016/j.neurobiolaging.2020.07.009⟩
Article dans une revue hal-03491473 v1
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Different Clinical Contexts of Use of Blood Neurofilament Light Chain Protein in the Spectrum of Neurodegenerative Diseases

Giovanni Palermo , Sonia Mazzucchi , Alessandra Della Vecchia , Gabriele Siciliano , Ubaldo Bonuccelli et al.
Molecular Neurobiology, 2020, 57 (11), pp.4667-4691. ⟨10.1007/s12035-020-02035-9⟩
Article dans une revue hal-03385896 v1
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A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

Harald Hampel , Filippo Caraci , A. Claudio Cuello , Giuseppe Mario Caruso , Robert Nisticò et al.
Frontiers in Immunology, 2020, 11, pp.456. ⟨10.3389/fimmu.2020.00456⟩
Article dans une revue hal-02570114 v1
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Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer’s Precision Medicine and Pharmacology

Harald Hampel , Edward J Goetzl , Dimitrios Kapogiannis , Simone Lista , Andrea Vergallo
Frontiers in Pharmacology, 2019, 10, pp.310. ⟨10.3389/fphar.2019.00310⟩
Article dans une revue hal-02095292 v1
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Reduction of recruitment costs in preclinical AD trials. Validation of automatic pre-screening algorithm for brain amyloidosis

Manon Ansart , Stéphane Epelbaum , Geoffroy Gagliardi , Olivier Colliot , Didier Dormont et al.
Statistical Methods in Medical Research, 2019, pp.096228021882303. ⟨10.1177/0962280218823036⟩
Article dans une revue hal-01964942 v2

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing

B. W. Kunkle , B. Grenier-Boley , R. Sims , J. C. Bis , V. Damotte et al.
Nature Genetics, 2019, 51 (3), pp.414-430. ⟨10.1038/s41588-019-0358-2⟩
Article dans une revue hal-03209563 v1
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Biomarker-guided clustering of Alzheimer's disease clinical syndromes

Nicola Toschi , Simone Lista , Filippo Baldacci , Enrica Cavedo , Henrik Zetterberg et al.
Neurobiology of Aging, 2019, 83, pp.42 - 53. ⟨10.1016/j.neurobiolaging.2019.08.032⟩
Article dans une revue hal-03488653 v1
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Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD

Andrea Vergallo , Marion Houot , Enrica Cavedo , Pablo Lemercier , Eugeen Vanmechelen et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2019, 15 (10), pp.1274 - 1285. ⟨10.1016/j.jalz.2019.07.001⟩
Article dans une revue hal-03489074 v1
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Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

Patrizia A Chiesa , Enrica Cavedo , Andrea Vergallo , Simone Lista , Marie-Claude Potier et al.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019, 15 (7), pp.940-950. ⟨10.1016/j.jalz.2019.03.006⟩
Article dans une revue hal-02368904 v1
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Plasma amyloid β 40/42 ratio predicts cerebral amyloidosis in cognitively normal individuals at risk for Alzheimer's disease

Andrea Vergallo , Lucile Mégret , Simone Lista , Enrica Cavedo , Henrik Zetterberg et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2019, 15 (6), pp.764 - 775. ⟨10.1016/j.jalz.2019.03.009⟩
Article dans une revue hal-03484725 v1

Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease

Enrica Cavedo , Simone Lista , Marion Houot , Andrea Vergallo , Michel Grothe et al.
Neurology, 2019, 94 (1), pp.e30-e41. ⟨10.1212/WNL.0000000000008696⟩
Article dans une revue hal-03769491 v1
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Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study

Ingrid S van Maurik , Stephanie J Vos , Isabelle Bos , Femke H Bouwman , Charlotte Teunissen et al.
The Lancet Neurology, 2019, 18 (11), pp.1034-1044. ⟨10.1016/S1474-4422(19)30283-2⟩
Article dans une revue inserm-02747461 v1
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Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Fatemah A Sakr , Michel J Grothe , Enrica Cavedo , Irina Jelistratova , Marie-Odile Habert et al.
Alzheimer's Research and Therapy, 2019, 11, pp.15. ⟨10.1186/s13195-019-0466-3⟩
Article dans une revue hal-02006123 v1

Relationship between Basal Forebrain Resting-State Functional Connectivity and Brain Amyloid-β Deposition in Cognitively Intact Older Adults with Subjective Memory Complaints

Patrizia Chiesa , Enrica Cavedo , Michel Grothe , Marion Houot , Stefan Teipel et al.
Radiology, 2019, 290 (1), pp.167-176. ⟨10.1148/radiol.2018180268⟩
Article dans une revue hal-03769435 v1
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Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease

Harald Hampel , Simone Lista , Christian Neri , Andrea Vergallo
Progress in Neurobiology, 2019, 181, pp.101662 -. ⟨10.1016/j.pneurobio.2019.101662⟩
Article dans une revue hal-03488187 v1
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Polygenic risk and hazard scores for Alzheimer's disease prediction

Ganna Leonenko , Rebecca Sims , Maryam Shoai , Aura Frizzati , Paola Bossù et al.
Annals of Clinical and Translational Neurology, 2019, 6 (3), pp.456-465. ⟨10.1002/acn3.716⟩
Article dans une revue hal-04444983 v1
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Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors

Stefan J Teipel , Enrica Cavedo , Harald Hampel , Michel J Grothe
Frontiers in Neurology, 2018, 9, pp.642. ⟨10.3389/fneur.2018.00642⟩
Article dans une revue hal-04412739 v1
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Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

Harald Hampel , Sid O'Bryant , José L Molinuevo , Henrik Zetterberg , Colin L. Masters et al.
Nature Reviews Neurology, 2018, 14 (11), pp.639-652. ⟨10.1038/s41582-018-0079-7⟩
Article dans une revue hal-01972372 v1

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

Willemijn Jansen , Rik Ossenkoppele , Betty Tijms , Anne Fagan , Oskar Hansson et al.
JAMA Psychiatry, 2018, 75 (1), pp.84. ⟨10.1001/jamapsychiatry.2017.3391⟩
Article dans une revue hal-04557184 v1

Evaluation of amyloid status in a cohort of elderly individuals with memory complaints: validation of the method of quantification and determination of positivity thresholds

Marie-Odile Habert , Hugo Bertin , Mickael Labit , Mamadou Diallo , Sullivan Marie et al.
Annals of Nuclear Medicine, 2018, 32 (2), pp.75 - 86. ⟨10.1007/s12149-017-1221-0⟩
Article dans une revue hal-01716483 v1
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Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

Bruno Dubois , Stéphane Epelbaum , Francis Nyasse , Hovagim Bakardjian , Geoffroy Gagliardi et al.
The Lancet Neurology, 2018, 17 (4), pp.335 - 346. ⟨10.1016/S1474-4422(18)30029-2⟩
Article dans une revue hal-01777834 v1
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Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel , Nicola Toschi , Claudio Babiloni , Filippo Baldacci , Keith L Black et al.
Journal of Alzheimer's Disease, 2018, 64 (s1), pp.S47 - S105. ⟨10.3233/jad-179932⟩
Article dans une revue hal-01910402 v1

Effect of Alzheimer's disease risk and protective factors on cognitive trajectories in subjective memory complainers: An INSIGHT‐preAD study

Stefan Teipel , Enrica Cavedo , Simone Lista , Marie‐odile Habert , Marie‐claude Potier et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2018, 14 (9), pp.1126-1136. ⟨10.1016/j.jalz.2018.04.004⟩
Article dans une revue hal-03769199 v1
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Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice

Soizic Lecocq , Katia Spinella , Bruno Dubois , Simone Lista , Harald Hampel et al.
PLoS ONE, 2018, 13 (1), pp.e0190212. ⟨10.1371/journal.pone.0190212⟩
Article dans une revue hal-01696067 v1

Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints

Enrica Cavedo , Patrizia Chiesa , Marion Houot , Maria Teresa Ferretti , Michel Grothe et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2018, 14 (9), pp.1204-1215. ⟨10.1016/j.jalz.2018.05.014⟩
Article dans une revue hal-03769203 v1

Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer’s Disease Dementia in Individuals With Mild Cognitive Impairment

Yong Shen , Haibo Wang , Qiying Sun , Hailan Yao , Andrew Keegan et al.
Biological Psychiatry, 2018, 83 (5), pp.447-455. ⟨10.1016/j.biopsych.2017.02.007⟩
Article dans une revue hal-04592298 v1
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila , Brenda Sullivan , Hilary Finucane , Walter Walters , Jose Bras et al.
Science, 2018, 360 (6395), eaap8757. ⟨10.1126/science.aap8757⟩
Article dans une revue cea-01870483 v1
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Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Rosalinde Slot , Sietske Sikkes , Johannes Berkhof , Henry Brodaty , Rachel Buckley et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2018, 15 (3), pp.465-476. ⟨10.1016/j.jalz.2018.10.003⟩
Article dans une revue hal-04517595 v1
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No association of cortical amyloid load and EEG connectivity in older people with subjective memory complaints

Stefan Teipel , Hovagim Bakardjian , Gabriel Gonzalez-Escamilla , Enrica Cavedo , Sarah Weschke et al.
Neuroimage-Clinical, 2018, 17, pp.435-443. ⟨10.1016/j.nicl.2017.10.031⟩
Article dans une revue hal-01738143 v1
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Gray Matter Network Disruptions and Regional Amyloid Beta in Cognitively Normal Adults

Mara ten Kate , Pieter Jelle Visser , Hovagim Bakardjian , Frederik Barkhof , Sietske A.M. Sikkes et al.
Frontiers in Aging Neuroscience, 2018, 10, pp.67. ⟨10.3389/fnagi.2018.00067⟩
Article dans une revue hal-01757310 v1
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Association of cerebrospinal fluid α‐synuclein with total and phospho‐tau 181 protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers

Andrea Vergallo , René‐sosata Bun , Nicola Toschi , Filippo Baldacci , Henrik Zetterberg et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2018, 14 (12), pp.1623-1631. ⟨10.1016/j.jalz.2018.06.3053⟩
Article dans une revue hal-03769208 v1
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Current state of Alzheimer’s fluid biomarkers

José Luis Molinuevo , Scott Ayton , Richard Batrla , Martin M Bednar , Tobias Bittner et al.
Acta Neuropathologica, 2018, 136 (6), pp.821-853. ⟨10.1007/s00401-018-1932-x⟩
Article dans une revue hal-01960281 v1
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Amyloidosis and neurodegeneration result in distinct structural connectivity patterns in mild cognitive impairment

Thomas Jacquemont , Fabrizio de Vico Fallani , Anne Bertrand , Stéphane Epelbaum , Alexandre Routier et al.
Neurobiology of Aging, 2017, ⟨10.1016/j.neurobiolaging.2017.03.023⟩
Article dans une revue hal-01518785 v1
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Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: A large-scale biomarker-characterized monocenter cohort study (ClinAD)

Stéphane Epelbaum , Marc Teichmann , Dalila Samri , Marcel Levy Nogueira , Harald Hampel et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2017, 13 (8), pp.913 - 923. ⟨10.1016/j.jalz.2016.12.014⟩
Article dans une revue hal-01672862 v1
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A Precision Medicine Initiative for Alzheimer's disease: the road ahead to biomarker-guided integrative disease modeling.

Harald Hampel , Sid O’bryant , Stanley Durrleman , Erfan Younesi , Katrine Rojkova et al.
Climacteric, 2017, 20 (2), pp.107-118
Article dans une revue hal-01566281 v1
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Rebecca Sims , Sven van Der Lee , Adam Naj , Céline Bellenguez , Nandini Badarinarayan et al.
Nature Genetics, 2017, 49 (9), pp.1373-1384. ⟨10.1038/ng.3916⟩
Article dans une revue inserm-02466466 v1

Preclinical Alzheimer's disease: A systematic review of the cohorts underlying the concept

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Cortical amyloid accumulation is associated with alterations of structural integrity in older people with subjective memory complaints

Stefan Teipel , Enrica Cavedo , Sarah Weschke , Michel Grothe , Katrine Rojkova et al.
Neurobiology of Aging, 2017, 57, pp.143-152. ⟨10.1016/j.neurobiolaging.2017.05.016⟩
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The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Isabelle Bos , Stephanie Vos , Lutz Frölich , Johannes Kornhuber , Jens Wiltfang et al.
Neurobiology of Aging, 2017, 56, pp.33-40. ⟨10.1016/j.neurobiolaging.2017.03.034⟩
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Preclinical Alzheimer's disease: a systematic review of the cohorts underlying the concept

Stéphane Epelbaum , Rémy Genthon , Enrica Cavedo , Marie Habert , Foudil Lamari et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2017, 13 (4), pp.454-467. ⟨10.1016/j.jalz.2016.12.003⟩
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Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

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World Journal of Biological Psychiatry, 2017, 19 (4), pp.244-328. ⟨10.1080/15622975.2017.1375556⟩
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Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

Ronald Lautner , Philip S Insel , Tobias Skillbäck , Bob Olsson , Mikael Landén et al.
Alzheimer's Research and Therapy, 2017, 9, pp.87. ⟨10.1186/s13195-017-0313-3⟩
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Two-level diagnostic classification using cerebrospinal fluid YKL-40 in Alzheimer's disease

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Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2017, ⟨10.1016/j.jalz.2017.01.021⟩
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Revolution of Resting-State Functional Neuroimaging Genetics in Alzheimer’s Disease

Patrizia A. Chiesa , Enrica Cavedo , Simone Lista , Paul M Thompson , Harald Hampel
Trends in Neurosciences, 2017, ⟨10.1016/j.tins.2017.06.002⟩
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Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline

Isabelle Bos , Frans R Verhey , Inez Ramakers , Heidi I L Jacobs , Hilkka Soininen et al.
Alzheimer's Research and Therapy, 2017, 9 (1), pp.101. ⟨10.1186/s13195-017-0328-9⟩
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Reduced basal forebrain atrophy progression in a randomized Donepezil trial in prodromal Alzheimer's disease

Enrica Cavedo , Michel J Grothe , Olivier Colliot , Simone Lista , Marie Chupin et al.
Scientific Reports, 2017, 7 (1), pp.11706. ⟨10.1038/s41598-017-09780-3⟩
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Blood‐based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic

Sid O’bryant , Michelle M Mielke , Robert A Rissman , Simone Lista , Hugo Vanderstichele et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2016, 13 (1), pp.45-58. ⟨10.1016/j.jalz.2016.09.014⟩
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Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer’s Disease

Enrica Cavedo , Bruno Dubois , Olivier Colliot , Simone Lista , Bernard Croisile et al.
Journal of Clinical Psychiatry, 2016, ⟨10.4088/JCP.15m10413⟩
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Implementation of subjective cognitive decline criteria in research studies

José L Molinuevo , Laura A Rabin , Rebecca Amariglio , Rachel Buckley , Bruno Dubois et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2016, 13 (3), pp.296-311. ⟨10.1016/j.jalz.2016.09.012⟩
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Predictors of cognitive decline and treatment response in a clinical trial on suspected prodromal Alzheimer's disease

Stefan J Teipel , Enrica Cavedo , Michel J Grothe , Simone Lista , Samantha Galluzzi et al.
Neuropharmacology, 2016, 108, pp.128-35. ⟨10.1016/j.neuropharm.2016.02.005⟩
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Excess of rare coding variants in PLD3 in late-but not early-onset Alzheimer's disease

Eva C Schulte , Alexander Kurz , Panagiotis Alexopoulos , Harald Hampel , Annette Peters et al.
Human Genome Variation, 2015, 2, pp.14028. ⟨10.1038/hgv.2014.28⟩
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Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer's disease: a voxel-based lesion mapping study

Katrin Morgen , Michael Schneider , Lutz Frölich , Heike Tost , Michael M. Plichta et al.
Alzheimer's Research and Therapy, 2015, 7, pp.27. ⟨10.1186/s13195-015-0111-8⟩
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Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

Bruno Dubois , Marie Chupin , Harald Hampel , Simone Lista , Enrica Cavedo et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2015, 11 (9), pp.1041-1049. ⟨10.1016/j.jalz.2014.10.003⟩
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Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges

Sid E. O'Bryant , Simone Lista , Robert A. Rissman , Melissa Edwards , Fan Zhang et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2015, 3, pp.27-34. ⟨10.1016/j.dadm.2015.12.003⟩
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Convergent genetic and expression data implicate immunity in Alzheimer's disease

Lesley Jones , Jean‐charles Lambert , Li‐san Wang , Seung‐hoan Choi , Denise Harold et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2014, 11 (6), pp.658 - 671. ⟨10.1016/j.jalz.2014.05.1757⟩
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Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020

Harald Hampel , Simone Lista , Stefan J Teipel , Francesco Garaci , Robert Nisticò et al.
Biochemical Pharmacology, 2014, pp.426-49
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Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

Valentina Escott-Price , Céline Bellenguez , Li-San Wang , Seung-Hoan Choi , Denise Harold et al.
PLoS ONE, 2014, 9 (6), pp.e94661. ⟨10.1371/journal.pone.0094661⟩
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The road ahead to cure Alzheimer’s disease: development of biological markers and neuroimaging methods for prevention trials across all stages and target populations

Enrica Cavedo , Simone Lista , Zaven S Khachaturian , Paul S Aisen , Philippe Amouyel et al.
The Journal of prevention of Alzheimer's disease, 2014, 1 (3), pp.181-202. ⟨10.14283/jpad.2014.32⟩
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert , Carla Ibrahim-Verbaas , Denise Harold , Adam Naj , Rebecca Sims et al.
Nature Genetics, 2013, 45 (12), pp.1452-1458. ⟨10.1038/ng.2802⟩
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Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment.

Laurence O'Dwyer , Franck Lamberton , Arun L W Bokde , Michael Ewers , Yetunde O Faluyi et al.
PLoS ONE, 2012, 7, pp.e32441
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Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer's disease.

Pascale Fehlbaum-Beurdeley , Olivier Sol , Laurent Désiré , Jacques Touchon , Thierry Dantoine et al.
Journal of Alzheimer's Disease, 2012, 32 (1), pp.169-81. ⟨10.3233/JAD-2012-120637⟩
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Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer's disease.

Pascale Fehlbaum-Beurdeley , Olivier Sol , Laurent Désiré , Jacques Touchon , Thierry Dantoine et al.
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Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study.

Laurence O'Dwyer , Franck Lamberton , Arun L W Bokde , Michael Ewers , Yetunde O Faluyi et al.
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Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease.

Laurence O'Dwyer , Franck Lamberton , Arun L W Bokde , Michael Ewers , Yetunde O Faluyi et al.
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Using diffusion tensor imaging and mixed-effects models to investigate primary and secondary white matter degeneration in Alzheimer's disease and mild cognitive impairment.

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Validation of Alzheimer's disease CSF and Plasma Biological Markers The Multi-Center Reliability Study of the Pilot European Alzheimer's Disease Neuroimaging Initiative (E-ADNI)

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Experimental Gerontology, 2009, 44 (9), pp.579. ⟨10.1016/j.exger.2009.06.003⟩
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Blood-based Biomarkers of Microvascular Pathology in Alzheimer's disease

Michael Ewers , Michelle M. Mielke , Harald Hampel
Experimental Gerontology, 2009, 45 (1), pp.75. ⟨10.1016/j.exger.2009.09.005⟩
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White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study

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Journal of Neurology, Neurosurgery and Psychiatry, 2009, 80 (10), pp.1069. ⟨10.1136/jnnp.2008.158881⟩
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Total and Phosphorylated Tau Protein as Biological Markers of Alzheimer's Disease

Harald Hampel , Kaj Blennow , Leslie M. Shaw , Yvonne C. Hoessler , Henrik Zetterberg et al.
Experimental Gerontology, 2009, 45 (1), pp.30. ⟨10.1016/j.exger.2009.10.010⟩
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P3-324: CONCURRENT EEG/FMRI NETWORK DYNAMICS ALTERATIONS IN COGNITIVELY INTACT INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASE

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AAIC'2019 Alzheimer’s Association International Conference, Jul 2019, Los Angeles, United States. pp.P1062-P1063, ⟨10.1016/j.jalz.2019.06.3356⟩
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P3-110: PRECLINICAL ALZHEIMER'S DISEASE: WHICH EEG BIOMARKERS FOR PRECISION MEDICINE?

Claudio Babiloni , Susanna Lopez , Claudio del Percio , Giuseppe Noce , Maria Teresa Pascarelli et al.
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P4-027: EVIDENCE FOR COGNITIVE COMPENSATION IN EARLY AMYLOIDOSIS IN HIGH-PERFORMING HEALTHY ELDERLY AT RISK FOR ALZHEIMER'S DISEASE

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Selection of amyloid positive pre-symptomatic subjects using automatic analysis of neuropsychological and MRI data for cost effective inclusion procedures in clinical trials

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Clinical Trials for Alzheimer's Disease, Nov 2017, Boston, United States. pp.295
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Prediction of amyloidosis from neuropsychological and MRI data for cost effective inclusion of pre-symptomatic subjects in clinical trials

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Multimodal Learning for Clinical Decision Support, Sep 2017, Quebec City, Canada
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Accuracy of MRI classification algorithms in a tertiary memory center clinical routine cohort

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The INSIGHT cohort: baseline analysis of structural MR imaging in asymptomatic subjects at risk for Alzheimer's disease

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AAIC, Jul 2016, Toronto, Canada. ⟨10.1016/j.jalz.2016.06.612⟩
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