Harold Duruflé

Research Scientist at INRAE
58
Documents
Affiliation actuelle
  • Biologie intégrée pour la valorisation de la diversité des Arbres et de la Forêt (BioForA)

Présentation

PROJECTS

On Going: 2026-2030 CARBOOST (PEPR SVA AAP2025, €500k) Carbon Boost in Woody Perennials under Stress. Project Coordinator.

2025-2027 TIMe-ID Consortium (INRAE DIGIT-BIO Metaprogram, €20k) Interdisciplinary Work on Methodologies for Integrating Temporal Data in Biology. Co-coordinator of the project.

2025-2028 EpiMyc (ANR-24-CE20-5751) The Epigenetics of Mycorrhizae. Co-coordinator of WP2.

Past: 2024 INRAE CSR Incubator Project (€8k) MicroGroves: Creating, maintaining, and evaluating micro-groves. Project Coordinator.

2017-2020 SUNRISE (Project IA-11-BTBR-0005) Sunflower genetic resources for improving oil production stability under water stress. Task leader 4.2 & 6.2 (systems biology approach).

RESEARCH EXPERIENCE

2021 Research Scientist: Integrative genomic prediction of complex phenotypes using system biology approach - Integrated Biology for the Development of Tree and Forest Diversity Laboratory, UMR INRAE/ONF 0588

2017 PostDoc position: Develop the systems biology approach within the SUNRISE project ; 3 years - Laboratory of Plant-Microbe Interactions, UMR 2594/441 CNRS/INRA, Toulouse, France - Team: Sunflower Genetics and Genomics (N. Langlade)

2014 Doctorate: “Production and treatment of heterogeneous Omics data in order to study the cell wall plasticity in A. thaliana ecotypes living at contrasted altitudinal level”; 3 years - Plant Science Research Laboratory, UMR 5546 UPS/CNRS, Toulouse, France (Pr C. Dunand) - Toulouse Mathematics Institute, France (Pr P. Besse)

2014 Crop ontology curator. Bioversity International, Montpellier Office (France); 10 months Team: Crop Ontology project of the Generation Challenge Programme (E. Arnaud)

Internship: 2013 Station Biologique de Roscoff, Marine Plants and Biomolecules, UMR 7139 UPMC/CNRS; 6 months

2012 Laboratory “Ecosystems, Biodiversity, Evolution”, UMR 6553 Rennes 1 University/CNRS; 3 months

2011 Laboratory of Plants Ecophysiological Responses to Environmental Stress, INRA Montpellier; 6 months

2010 Laboratory “Ecology Systematic Evolution”, Paris-Sud 11 University; 4 months Team: Photosynthesis, environment and adaptation (P. Streb & G. Cornic)

2004-2011 Joseph Fourier Alpine Station, Alpine Botanical garden of Lautaret; Internship 2 months / year

EDUCATION

2017 PhD of Agronomic and Ecological Sciences, specializing in plant development University of Toulouse

2013 M.Sc. Degree: Integrative plant biology: Gene, Plant, Agro-system 6 collaborating universities & Agrocampus Ouest (France) Major: Physiology/Metabolism and Eco-Physiology.

2011 BSc Degree: Functional Plant Biology Montpellier 2 University (France)

TEACHING and MENTORING

Supervision:

PhD:

2021-2022 - Abdou Rahmane Wade. Improved genome-based phenotypic predictions with a systems biology approach. (Co-doctoral advisor: Leopoldo Sanchez Rodriguez & Vincent Segura) 2022-2025 - Alexandre Duplan. Improvement of pan-genomic knowledge and prediction of complex phenotypes by an integrative multi-omics approach. (Co-doctoral advisor: Leopoldo Sanchez Rodriguez & Stephane Maury) 2025-on going - Thomas Wacquet. Machine learning and epigenotyping: a new lever for improving phenotype prediction in plants in an agroecological context. (Co-doctoral advisor: Mathieu Emily & Stephane Maury)

PostDoc: 2022 - Xabi Cazenave

Teaching:

Since 2025: Saclay University: Integrative study of omics data. Master 2 Since 2024: Orléans University: Integrative biology within the framework of plant biology. Master 2 2015 - 2017: Toulouse University, biostatistics and biophysics at BSc. Degree,

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Publications

Multi-omics Data Integration in the Context of Plant Abiotic Stress Signaling

Harold Duruflé , Sébastien Déjean

Plant Abiotic Stress Signaling, 2642, Springer US, pp.295-318, 2023, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3044-0_16⟩

Chapitre d'ouvrage hal-04040408v1

Epigenetic regulation of mycorrhizal symbioses: from plastic responses to transgenerational legacies

Gerson Beltrán-Torres , Henry J. de la Cruz , Stéphane Maury , Martina Janoušková , Claire Veneault-Fourrey et al.

New Phytologist, 2026, early view, ⟨10.1111/nph.70982⟩

Article dans une revue hal-05500190v1

Drought-Induced Epigenetic Memory in the cambium of Poplar Trees persists and primes future stress responses

Alexandre Duplan , Yu-Qi Feng , Gwenvaël Laskar , Bao-Dong Cai , Vincent Segura et al. Article dans une revue hal-05322036v1
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Natural variation in chalcone isomerase defines a major locus controlling radial stem growth variation among Populus nigra populations

Harold Duruflé , Annabelle Déjardin , Véronique Jorge , Marie Pégard , Gilles Pilate et al.

Peer Community Journal, 2025, 5, pp.e50. ⟨10.24072/pcjournal.559⟩

Article dans une revue hal-05070106v1
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Genetic control of abiotic stress-related specialized metabolites in sunflower

Marco Moroldo , Nicolas Blanchet , Harold Duruflé , Stéphane Bernillon , Thierry Berton et al.

BMC Genomics, 2024, 25 (1), pp.199. ⟨10.1186/s12864-024-10104-9⟩

Article dans une revue hal-04468891v1
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Comprehensive Organ-Specific Profiling of Douglas Fir (Pseudotsuga menziesii) Proteome

Caroline Teyssier , Odile Rogier , Stéphane Claverol , Florian Gautier , Marie-Anne Lelu-Walter et al.

Biomolecules, 2023, 13 (9), pp.1400. ⟨10.3390/biom13091400⟩

Article dans une revue hal-04209576v1
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Sunflower Hybrids and Inbred Lines Adopt Different Physiological Strategies and Proteome Responses to Cope with Water Deficit

Harold Duruflé , Thierry Balliau , Nicolas Blanchet , Adeline Chaubet , Alexandra Duhnen et al.

Biomolecules, 2023, 13 (7), pp.1110. ⟨10.3390/biom13071110⟩

Article dans une revue hal-04161450v1
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eQTLs are key players in the integration of genomic and transcriptomic data for phenotype prediction

Abdou Rahmane Wade , Harold Duruflé , Leopoldo Sanchez , Vincent Segura

BMC Genomics, 2022, 23 (1), pp.476. ⟨10.1186/s12864-022-08690-7⟩

Article dans une revue hal-04031548v1
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Gene regulatory network inference methodology for genomic and transcriptomic data acquired in genetically related heterozygote individuals

Lise Pomiès , Celine Brouard , Harold Duruflé , Élise Maigné , Clément Carré et al.

Bioinformatics, 2022, 38 (17), pp.4127-4134. ⟨10.1093/bioinformatics/btac445⟩

Article dans une revue hal-03776333v1
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Proteomic data from leaves of twenty-four sunflower genotypes under water deficit

Thierry Balliau , Harold Duruflé , Nicolas Blanchet , Melisande Blein-Nicolas , Nicolas Langlade et al.

OCL Oilseeds and fats crops and lipids, 2021, 28, ⟨10.1051/ocl/2020074⟩

Article dans une revue (data paper) hal-03139476v1
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Leaf metabolomic data of eight sunflower lines and their sixteen hybrids under water deficit

Thierry Berton , Stéphane Bernillon , Olivier Fernandez , Harold Duruflé , Amélie Flandin et al.

OCL Oilseeds and fats crops and lipids, 2021, 28, 42 - 6 p. ⟨10.1051/ocl/2021029⟩

Article dans une revue (data paper) hal-03321074v1
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A powerful framework for an integrative study with heterogeneous omics data: from univariate statistics to multi-block analysis

Harold Duruflé , Merwann Selmani , Philippe Ranocha , Elisabeth Jamet , Christophe Dunand et al.

Briefings in Bioinformatics, 2021, 22 (3), pp.bbaa166. ⟨10.1093/bib/bbaa166⟩

Article dans une revue hal-02921927v3
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An integrative Study Showing the Adaptation to Sub-Optimal Growth Conditions of Natural Populations of Arabidopsis thaliana: A Focus on Cell Wall Changes

Harold Duruflé , Philippe Ranocha , Thierry Balliau , Michel Zivy , Cécile Albenne et al.

Cells, 2020, 9 (10), pp.2249. ⟨10.3390/cells9102249⟩

Article dans une revue hal-02965604v1
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Données transcriptomiques de feuilles de huit lignées de tournesol et de leurs 16 hybrides soumis à un stress hydrique

Louise Gody , Harold Duruflé , Nicolas Blanchet , Clément Carré , Ludovic Legrand et al.

OCL Oilseeds and fats crops and lipids, 2020, 27, pp.48. ⟨10.1051/ocl/2020044⟩

Article dans une revue (data paper) hal-02974900v1

RNA expression dataset of 384 sunflower hybrids in field condition

Charlotte Penouilh-Suzette , Lise Pomies , Harold Duruflé , Nicolas Blanchet , Fanny Bonnafous et al.

OCL Oilseeds and fats crops and lipids, 2020, 27, pp.36. ⟨10.1051/ocl/2020027⟩

Article dans une revue (data paper) hal-02912579v1
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Transcriptomic and cell wall proteomic datasets of rosettes and floral stems from five Arabidopsis thaliana ecotypes grown at optimal or sub-optimal temperature

Harold Duruflé , Philippe Ranocha , Thierry Balliau , Christophe Dunand , Elisabeth Jamet

Data in Brief, 2019, 27, pp.104581. ⟨10.1016/j.dib.2019.104581⟩

Article dans une revue (data paper) hal-02938744v1
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Phenotyping and cell wall polysaccharide composition dataset of five arabidopsis ecotypes grown at optimal or sub-optimal temperatures

Harold Duruflé , Cécile Albenne , Elisabeth Jamet , Christophe Dunand

Data in Brief, 2019, 25, pp.104318. ⟨10.1016/j.dib.2019.104318⟩

Article dans une revue (data paper) hal-03121670v1
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Phenotypic Trait Variation as a Response to Altitude-Related Constraints in Arabidopsis Populations

Harold Duruflé , Philippe Ranocha , Duchesse Lacour Mbadinga Mbadinga , Sébastien Dejean , Maxime Bonhomme et al.

Frontiers in Plant Science, 2019, 10, pp.430. ⟨10.3389/fpls.2019.00430⟩

Article dans une revue hal-02115698v1
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Metabolomic characterization of sunflower leaf allows discriminating genotype groups or stress levels with a minimal set of metabolic markers

Olivier Fernandez , Maria Urrutia , Thierry Berton , Stéphane Bernillon , Catherine Deborde et al.

Metabolomics, 2019, 15 (4), pp.56. ⟨10.1007/s11306-019-1515-4⟩

Article dans une revue hal-02487236v1
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Data describing the eco-physiological responses of twenty-four sunflower genotypes to water deficit

Nicolas Blanchet , Pierre Casadebaig , Philippe Debaeke , Harold Duruflé , Louise Gody et al.

Data in Brief, 2018, 21, pp.1296-1301. ⟨10.1016/j.dib.2018.10.045⟩

Article dans une revue (data paper) hal-02625452v1

Cell wall proteome analysis of Arabidopsis thaliana mature stems

Harold Duruflé , Hélène San Clemente , Thierry Balliau , Michel Zivy , Christophe Dunand et al.

Proteomics, 2017, 17 (8), pp.1-5. ⟨10.1002/pmic.201600449⟩

Article dans une revue (data paper) hal-01606770v1
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Proline hydroxylation in cell wall proteins: is it yet possible to define rules?

Harold Duruflé , Vincent Hervé , Thierry Balliau , Michel Zivy , Christophe Dunand et al.

Frontiers in Plant Science, 2017, 8, ⟨10.3389/fpls.2017.01802⟩

Article dans une revue hal-02620851v1

Cell wall modifications of two Arabidopsis thaliana ecotypes, Col and Sha, in response to sub-optimal growth conditions

Harold Duruflé , Vincent Hervé , Philippe Ranocha , Thierry Balliau , Michel Zivy et al.

Plant Science, 2017, 263, pp.183-193. ⟨10.1016/j.plantsci.2017.07.015⟩

Article dans une revue hal-03121655v1
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Herbivore-induced chemical and molecular responses of the kelps Laminaria digitata and Lessonia spicata

Andrés A Ritter , Léa Cabioch , Loraine A Brillet-Guéguen , Erwan A Corre , Audrey A Cosse et al.

PLoS ONE, 2017, 12 (3), pp.e0173315. ⟨10.1371/journal.pone.0173315.s011⟩

Article dans une revue hal-01587420v1

An enlarged cell wall proteome of Arabidopsis thaliana rosettes.

Vincent Hervé , Harold Duruflé , Hélène San Clemente , Cécile Albenne , Thierry Balliau et al.

Proteomics, 2016, 16 (24), pp.3183-3187. ⟨10.1002/pmic.201600290⟩

Article dans une revue (data paper) istex pasteur-01421109v1
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The role of epigenetics in local adaptation in sessile oak trees: a population epigenetic association study

Shannon Brandt , Alexandre Duplan , Isabelle Lesur Kupin , Odile Rogier , Mamadou Dia Sow et al.

ESEB 2025 - The Evolutionary Biology Congress, Aug 2025, Barcelone, Spain

Communication dans un congrès hal-05241621v1
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Multi-omics systems biology approach to reveal heterosis and drought response genomic processes in sunflower

Harold Duruflé

Journées des OMIQUES VEGETALES, Les plateformes omiques végétales du plateau de Saclay, Jun 2024, Saclay, France, France

Communication dans un congrès hal-04628618v1
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Une approche de biologie des systèmes pour mieux comprendre le déterminisme génétique de la production et de la qualité du bois du peuplier

Harold Duruflé , Annabelle Déjardin , Véronique Jorge , Marie Pégard , Gilles Pilate et al.

Journée Xylogénèse 2024, Groupe de Travail Xylogenèse du GDR Sciences du Bois, Jun 2024, Orléans, France

Communication dans un congrès hal-04628657v1

Integration of omics data: example of analysis in a plant biology context

Harold Duruflé

Journées du Groupe Vigne de BAP et ses amis, Nov 2023, Colmar, France

Communication dans un congrès hal-04300759v1

Contribution of an integrative study to the understanding of plant adaptation to their environment: A focus on plant cell walls.

Harold Duruflé , Sébastien Dejean

Cell Wall Days, Oct 2020, Toulouse, France

Communication dans un congrès hal-03509280v1

Multivariate analyses of heterogeneous omics data highlights the emergence of novel molecular and physiological strategies of drought response in sunflower.

Harold Duruflé , Thierry Balliau , Nicolas Blanchet , Melisande Blein-Nicolas , Brigitte Mangin et al.

Omics Days, Feb 2020, Montpellier, France

Communication dans un congrès hal-03509300v1
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Introduction to Ontology Semantics & tools for data annotation

Harold Duruflé

2d Rencontres du réseau SPE (INRA), Mar 2019, Toulouse, France

Communication dans un congrès hal-03511777v1

Sunflower hybrids and inbred lines adopt different molecular and physiological strategies to respond to water deficit

Harold Duruflé , Thierry Balliau , Nicolas Blanchet , Melisande Blein-Nicolas , Adeline Chaubet et al.

Green Proteome, Jun 2019, Paris, France

Communication dans un congrès hal-03509317v1

Statistical learning on heterogeneous omics data highlights the molecular basis of heterosis of drought response in sunflower

Harold Duruflé , Thierry Balliau , Nicolas Blanchet , Melisande Blein-Nicolas , A Chaubet et al.

Plant and Animal Genome XXVII, Jan 2019, San Diego, United States

Communication dans un congrès hal-02391988v1

Arabidopsis thaliana as a model plant to study acclimation to sub-optimal growth conditions: An integrative study combining omics approaches reveals the importance of the cell wall.

Harold Duruflé , Vincent Hervé , Thierry Balliau , Michel Zivy , Sébastien Dejean et al.

INPPO World Congress, Sep 2018, Padoue, Italy

Communication dans un congrès hal-03509374v1

Proteome responses to water deficit in sunflower: genetic variability, heterosis and links with phenotypic traits.

Harold Duruflé , Thierry Balliau , Melisande Blein-Nicolas , Nicolas Blanchet , Adeline Chaubet et al.

INPPO World Congress, Sep 2018, Padova, Italy

Communication dans un congrès hal-03509356v1

Cell wall adaptation to sub-optimal growth conditions of natural population of Arabidopsis.

Harold Duruflé , Philippe Ranocha , Sébastien Dejean , Thierry Balliau , Michel Zivy et al.

11es Journées du Réseau Français des Parois, Jun 2017, Orléans, France

Communication dans un congrès hal-03509390v1

Analysis and integration of heterogeneous data from response to low temperature condition of two Arabidopsis thaliana ecotypes

Harold Duruflé , Vincent Hervé , Philippe Ranocha , Cécile Albenne , Sébastien Dejean et al.

COST FA1306, Workgroup 2, Feb 2016, Versailles, France

Communication dans un congrès hal-03509455v1

Harmonizing trait classes in the crop ontology & aligning with plant and trait ontologies

Harold Duruflé , Marie-Angelique Laporte , Matteis Lucas , Elizabeth Arnaud

Workshop on Crop Ontology and Phenotyping Data Interoperability, Mar 2014, Montpellier, France

Communication dans un congrès hal-03509472v1
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The role of epigenetics in local adaptation in oak trees: a population epigenetic analysis

Shannon Brandt , Ludovic Duvaux , Isabelle Lesur , Odile Rogier , Mamadou Sow et al.

5th Epicatch meeting, Jul 2024, Bordeaux, France

Poster de conférence hal-05228453v1

Epigenetic Variation in Tree Evolution: a case study in black poplar (Populus nigra)

Mamadou Dia Sow , Odile Rogier , Isabelle Lesur , Christian Daviaud , Emile Mardoc et al.

Plant Epigenetics (EPIPLANT/SEB 2024), Jul 2024, Clermont-Ferrand, France. , Abstract book of EPIPLANT/SEB 2024, Session VI Chromatin in transcription, replication and repair (Poster #69), pp.131-132

Poster de conférence hal-05056784v1
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What epigenetics can bring to (plant) physiologists and ecologists in a climate change context

Alexandre Duplan , Régis Fichot , Mamadou Dia Sow , Alain Delaunay , Isabelle Le Jan et al.

Biotechnocentre, Oct 2023, Nouan-le-Fuzelier, France.

Poster de conférence hal-04283904v1
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Etude des variations géographiques, génétiques et temporelles de la phénologie de floraison chez le peuplier noir

Xabi Cazenave , Véronique Jorge , Marc Villar , Harold Duruflé

Premières journées doctorales de la forêt, Apr 2023, Blois, France.

Poster de conférence hal-04071607v1
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Trees short-time and inter-annual epigenetic somatic memories in response to drought-rewatering cycles

Alexandre Duplan , Régis Fichot , Mamadou Dia Sow , Alain Delaunay , Isabelle Lejan et al.

14th International Conference of the French Society of Plant Biology, Jul 2023, Marseille, France.

Poster de conférence hal-04157492v1
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Exploration du génome du peuplier noir : identification de variations structurales

Romane Guilbaud , Véronique Jorge , Odile Rogier , Leopoldo Sanchez Rodriguez , Patricia Faivre-Rampant et al.

1. colloque INRAE Genomics, May 2022, Orléans, France.

Poster de conférence hal-03937688v1
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eQTLs are key players in the integration of genomic and transcriptomic data for phenotype prediction

Abdou Rahmane Wade , Harold Duruflé , Leopoldo Sanchez , Vincent Segura

B4EST International Conference: Managing Forest Genetic Resources (FGR) for an Uncertain Future, Jun 2022, Lisboa, Portugal. 2022

Poster de conférence hal-04540839v1
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Short reads et trios, un duo gagnant pour l'identification de variations structurales chez le peuplier noir

Romane Guilbaud , Odile Rogier , Véronique Jorge , Harold Duruflé , Leopoldo Sanchez Rodriguez et al.

Mini congrès, Jun 2022, Evry, France

Poster de conférence hal-03937654v1
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An integrative systems biology approach to study the genetic variability and the molecular involved in sunflower heterosis responses to drought stress

Harold Duruflé

GisBV symposium inter-PIA, Oct 2019, Paris, France

Poster de conférence hal-03511754v1
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A systems biology approach to study the genetic variability of proteome responses to water deficit in sunflower

Harold Duruflé , Thierry Balliau , Nicolas Blanchet , Mélisande Blein-Nicolas , Adeline Chaubet et al.

First International Plant Systems Biology meeting, Sep 2018, Roscoff, France.

Poster de conférence hal-03511745v1
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Phenotypic trait variation in genetically distincts Arabidopsis thaliana populations from the Pyrenees Mountains highlight acclimation to environmental constraints.

Harold Duruflé , Philippe Ranocha , Duchesse Lacour Mbadinga Mbadinga , Sébastien Déjean , Maxime Bonhomme et al.

9th European Plant Science Retreat, Mar 2017, Toulouse, France. , 1p

Poster de conférence hal-03511709v1
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Analysis and integration of heterogeneous data from response to low temperature condition of two Arabidopsis thaliana ecotypes

Harold Duruflé , Vincent Hervé , Philippe Ranocha , Cécile Albenne , Sébastien Déjean et al.

Day of the Doctoral School SEVAB, Mar 2016, Toulouse, France

Poster de conférence hal-03511731v1
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Production and treatment of heterogeneous omics data in order to study the cell wall plasticity in various Pyrenean altitudinal A. thaliana ecotypes

Harold Duruflé , Vincent Hervé , Philippe Ranocha , Cécile Albenne , Josiane Chourré et al.

Day of the Doctoral School SEVAB, Mar 2015, Toulouse, France

Poster de conférence hal-03511721v1