Hervé Guillou
- Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
- Département Santé Animale (DEPT SA)
- ToxAlim (ToxAlim)
Présentation
Hervé Guillou (INRAE Toulouse) Born in Brest 13/09/1975 https://orcid.org/0000-0002-5363-9081 Since 2018: Member of unit board of directors (UMR1331 INRAE Toulouse) Since 2016: Senior investigator (DR) INRAE Toulouse, ToxAlim Since 2009: Group leader, “Integrative Toxicology and Metabolism”, INRAE ToxAlim 2008: Junior investigator (CR) INRAE Toulouse, Molecular Pharmacology (Dir: Dr T. Pineau) 2004 –2007: Post-doctoral scientist at Babraham Institute (Cambridge UK) Cell Signaling department (led by Dr L.R. Stephens et Dr P.T. Hawkins) 2000- 2004: Assistant lecturer in biochemistry, Agrocampus Rennes Degrees 2014: HDR – Toulouse University (France) 2004: PhD in biochemistry and Cell Biology (Rennes University, France) 2000: MSc in Physiology (Rennes University, France) Teaching and training Teaching: Pre-clinical Toxicology, Molecular endocrinology, Metabolism, Physiology and Hepatology, Lipid Biochemistry (MSc, University of Toulouse) PhD Supervised (and current position): Dr Simon Ducheix (PhD 2014; PI INSERM Nantes), Dr Alexia Buis (PhD 2018; started her own company), Dr Marion Régnier (PhD 2018; Post-doc, Institut Cochin), Dr Sarra Smati (MD, PhD 2019; Assistant Professor, University of Nantes), Dr Tiffany Fougeray (PhD 2020; Post-doc, Harvard Medical School), Dr Léonie Dopavogui (PhD 2021; Industry, Canada). Post-doctoral scientist (and current position): Dr Normand Podechard (2009-2011; Professor Rennes University of Pharmacy), Dr Alexandra Montagner (2011-2016; Principal Investigator INSERM Toulouse), Dr Anne Fougerat (2017-2021; Principal Investigator INRAE Toulouse), Dr Elena Piccinin (2022; Assistant Professor, University of Bari). Fundings & Awards Young scientist award from the French Society of Nutrition in 2014 Awards from the Francophone Society of Diabetes in 2015 and 2019 Fundings: ANR, ARC, INCA, SFD, SFN, AFEF, Occitanie, ANSES, FRM, EU (JPI) Publications & Communication 80 talks including selected oral communications at international meetings (Keystone Symposium; EMBO Meeting, EASD, EASL) 110 peer reviewed publications in international journals Full publication list available at https://scholar.google.fr/citations?user=Toi0KcYAAAAJ&hl=fr
Publications
Publications
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Pesticide exposure profiles through tap water consumption in the NutriNet-Santé cohort in 202218th European Public Health Conference 2025 Investing for sustainable health and well-being, Nov 2025, Helsinki, Finland. pp.IV245, ⟨10.1093/eurpub/ckaf161.599⟩ |
Impact of exposure to a binary mixture of pesticides at reference doses on hepatic metabolism59th Congress of the European Societies of Toxicology (EUROTOX 2025), Sep 2025, Athène, Greece. pp.S150-S151, ⟨10.1016/j.toxlet.2025.07.368⟩ |
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What is the value of Imaging Mass Spectrometry coupled with Ion mobility to discriminate biomarkers? Study of a steatotic liver disease associated with metabolic dysfunction case4emes Journées Scientifiques du GdR-MSI, GdR-MSI, Jul 2025, Montpellier, France |
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Apport de l'imagerie MS dans le domaine de la toxicologie alimentaireJournées annuelles du GDR-MSI, Jun 2024, Strasbourg, France |
Study of genotoxic effects on exocrine pancreas after chronic dietary exposure to cocktail of pesticides15th ICAW - International Comet Assay Workshop, Sep 2024, Rovinj, Croatia |
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Rôle de PPARα hépatocytaire dans le contrôle transcriptionnel de l’adaptation à un régime cétogèneCongrès de la Société Francophone du Diabète 2023, Mar 2023, Montpellier, France |
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Effects of thermoneutral housing in a mouse model of non-alcoholic fatty liver disease59th Annual Meeting of the European Association for the Study of Diabetes (EASD), Oct 2023, Hamburg, Germany. pp.1007 |
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Rôle de PPARα hépatocytaire dans le contrôle transcriptionnel de l’adaptation à un régime cétogèneCongrès annuel de recherche translationnelle de la FHU IMPACT, Nov 2023, Toulouse, France |
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Hepatocyte PPARα is required for the sensing of adipose-derived fatty acids and for full brown adipose tissue activation during lipolysis58th annual meeting European Association for the Study of Diabetes, Sep 2022, Stockholm, Sweden |
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Effets d’une exposition alimentaire, périnatale et chronique alimentaire, à des doses réglementaires de glyphosate sur l’axe microbiote intestinal-intestin-foie13ème congrès annuel de la Société Francophone de Santé et Environnement, Nov 2022, Valence, France |
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Rôle de PPARα hépatocytaire dans le dialogue entre le foie et les tissus adipeux lors de la lipolyseCongrès de la Société Francophone du Diabète 2022, Mar 2022, Nice, France |
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Early life stress induces type 2 diabetes-like features in ageing miceNeuroGASTRO 2019 Congress, Sep 2019, Lisbonne, Portugal. 1 p |
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Sex dimorphic role of estrogen receptor a in physiological regulation of hepatic metabolism55. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Sep 2019, Barcelona, Spain. 1 p |
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Constitutive Androstane Receptor deficiency leads to sexually dimorphic metabolic disorders in aging54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Oct 2018, Berlin, France. pp.1 |
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Hepatocyte PI3Kα controls the PPARα-FGF21 axis and regulates whole body fatty acid homeostasisEuropean Assocation for the Study of Diabetes (EASD), Oct 2018, Berlin, Germany |
Hepatokines in metabolic disease: novel insights into FGF21 regulation by glucose52. Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, May 2018, Barcelone, Spain. pp.1 |
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Influence of gender on progression of liver metabolic diseases in response to different nutritional challenges54. Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Oct 2018, Berlin, Germany. pp.1 |
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Intracellular lipids: an independent cause of liver injury and chronic kidney disease in non-alcoholic fatty liver disease-like contextG2L2, Oct 2018, Genève, Switzerland |
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Early life stress induces type 2 diabetes at adulthood in male mice10. International Meeting of Pediatric Endocrinology, Sep 2017, Washington, United States |
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Hepatocyte PI3Kα controls the PPARα-FGF21 axis and regulates whole body fatty acid homeostasisEMBO meeting, Apr 2017, Majorqua, Spain |
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Chronic maternal separation in mice impaired immuno-metabolism in older offspring on standard dietThe Neonatal Window of Opportunity, Early Priming for Life, Herrenhausen Conference, Dec 2016, Hanovre, Germany |
Specific modulation of hepatic estrogen receptor alpha prevents fatty liver but also obesity and insulin resistance induced by a high fat diet in mice50th International Liver Congress of the European-Association-for-the-Study-of-the-Liver, European Association for the Study of the Liver (EASL). Genève, CHE., Apr 2015, Vienne, Austria. 1 p |
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Partial inhibition of hormone-sensitive lipase improves insulin sensitivity by induction of de novo lipogenesis and elongase ELOVL6 in human adipocytes51. Annual Meeting of the European Association for the Study of Diabetes (EASD), European Association for the Study of Diabetes (EASD). Düsseldorf, GBR., Sep 2015, Stockholm, Sweden. 2 p |
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Contribution of the nuclear receptors PXR and CAR to gene expression modulations induced by fipronil in rodent liver4th Health Food Symposium, Pôle Aliment Sécurité Sanitaire & Santé (PA3S)., 2012, Toulouse, France |
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Contribution of the nuclear receptors PXR and CAR to gene expression modulations induced by fipronil in rodent liver12th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT), Jul 2012, Noordwijkerhout, Netherlands. pp.1-182 |
L’expression d’une forme active de ChREBP conduit à la réinduction de la lipogenèse dans un modèle animal de déficience en LXR et SREBP-1c69èmes journées de l'Agence Française d’Etude du Foie, Saisissez le nom du laboratoire, du service ou du département., Ville service., Sep 2011, Paris, France |
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ELOVL2 controls the level of n-628:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice52. International Conference on the Bioscience of Lipids : Expanding the Horizons of Lipidomics, International Conference on the Bioscience of Lipids (ICBL). INT., Aug 2011, Varsovie, Poland. ⟨10.1016/j.chemphyslip.2011.05.035⟩ |
Role of LXR in hepatic fatty acid homeostasis revealed through a nutrigenomic approachJournées des récepteurs nucléaires, Muséum National d’Histoire Naturelle (MNHN). Saisissez le nom du laboratoire, du service ou du département., Paris, FRA., Mar 2011, Paris, France |
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Regulation of hepatic lipid metabolism: effect of dietary fatty acids and effect of Bisphenol ACentre de Génomique Integrative de Lausanne, Centre de Génomique Integrative de Lausanne., Feb 2011, Lausanne, Switzerland |
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Regulation of hepatic lipid metabolism: effect of dietary fatty acids and effect of Bisphenol A.ENS Lyon, Ecole Normale Supérieure (ENS). Dr Hugo Aguilaniu, Lyon, FRA., Apr 2011, Lyon, France |
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An xosysterol sensor and a master regulator of lipogenesisENOR meeting, Saisissez le nom du laboratoire, du service ou du département., Ville service., Sep 2011, Rome, Italy |
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Oxysterol signaling in fatty acid metabolismINSERM U915, L'institut du Thorax, Saisissez le nom du laboratoire, du service ou du département., Ville service., Jan 2011, Nantes, France |
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Régulation du Liver X Receptor par le fructose et développement de la stéatose hépatique9. Journées Francophones de Nutrition (JFN), Ville service., Dec 2011, Reims, France |
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Rôle de LXR dans le métabolisme des acides grasInstitut Cochin, Institut Cochin. Dr Catherine Postic, Ville service, FRA., Mar 2011, Cochin, France |
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Integrating QTL controlling fatness, lipid metabolites and gene expressions to genetically dissect the adiposity complex trait in a meat chicken cross62. Annual Meeting of the European Association for Animal Production (EAAP), Aug 2011, Stavanger, Norway |
Nuclear receptors in the transcriptional control of hepatic fatty acid metabolismThe Wenner-Gren Institute, University of Stockholm, Sep 2009, Stockholm, Sweden. pp.Inconnu |
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A minimal and dynamic model for fatty acid metabolism in mouse liverJournées Ouvertes de Biologie, Informatique et Mathématique (JOBIM), Jun 2008, Lille (FR), France |
A minimal and dynamical model for fatty acid metabolism in mouse liverJournées Ouvertes Biologie Informatique Mathématiques, 2008, Lille, France. pp.Inconnu |
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A kinetic view of coordinate modulations of gene expression and metabolism in wild-type and PPARa-/- mice during fastingGene signature symposia, 2005, Paris, France. pp.Inconnu |
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Influence des acides gras alimentaires sur les voies de signalisation des récepteurs nucléaires : une étude comparée de signatures transcriptomique et lipidomiqueJournées Scientifiques du GIS « PA-3S », 2005, Boussens, France. pp.Inconnu |
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PPARa remplit-il véritablement la fonction de senseur nutritionnel vis-à-vis des acides gras alimentaires ? Une étude comparée de signatures transcriptomique et lipidomiqueJournée GERLI de lipidomique, 2005, Toulouse, France. pp.Inconnu |
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Empreintes transcriptionnelles de lipides alimentaires sur modèles sourisAnalyse intégrée de signatures variées GENOTOUL, 2005, Toulouse, France. pp.Inconnu |
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A kinetic view of coordinate modulations of gene expression and metabolism in wild-type and PPARa-/- mice during fastingCycles de conferences de l'IFR31, 2005, Toulouse, France. pp.Inconnu |
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A kinetic view of coordinate modulations of gene expression and metabolism in wild type and PPARa-/- mice during fastingConference of the Paul Hamel Institute / New developements in the metabolic syndrome, 2004, Monaco, France. pp.Inconnu |
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Is PPARa a true nutritional sensor for dietary fatty acids: a coordinate transcriptomic and lipidomic studyJournée d’animation scientifique de l’IFR31, 2004, Toulouse, France. pp.Inconnu |
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Biological effects of nutrients : what interdisciplinary strategies to grasp and analyze complex signaturesJournée d’animation du Département d’Alimentation Humaine de l’INRA, 2004, Paris, France. pp.Inconnu |
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Characterization of hepatic effects induced by food lipids from the analysis of their biological signatures in miceJournée d’animation du Département d’Alimentation Humaine de l’INRA, 2004, Paris, France. pp.Inconnu |
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Expression and activity of two recombinant isoforms of rat NMT16th Congress of International Society for the Study of Fatty Acids and Lipids (ISSFAL), Jun 2004, Brighton, United Kingdom |
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Caractérisation des effets hépatiques induits par les lipides alimentaires par analyse de leurs signatures biologiques chez la sourisJournée d’animation scientifique de l’IFR30, 2004, Toulouse, France. pp.Inconnu |
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Regulation of hepatic desaturases by PPAR alphaInconnu, 2003, pp.Inconnu |
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Effects of dietary fatty acids on the expression of an array of class II nuclear receptor target genesInconnu, 2003, pp.Inconnu |
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Activité de la myristoyl-CoA: protéine N-myristoyltransférase de rat exprimée dans les cellules COS-7.Groupe d’Etude et de Recherche sur les Lipides et les Lipoprotéines (GERLI), Diversité moléculaire et physiopathologie, Sep 2003, Paris, France |
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Effet des acides gras saturés sur l’activité et l’expression des D6- et D5-désaturases4èmes Journées Francophones de Nutrition, Nov 2002, Dijon, France |
Transcriptional regulation of hepatic fatty acid metabolismSubcellular Biochemistry: Lipids in Health and Disease, Springer, 2009 |
Preuve de concept ARCHIPL: Bilan de l'évaluation in vitro de la rétention du déoxynivalénol par des parois de levure modifiées par hémisynthèse[Contrat] Inrae. 2014 |