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Hervé Meudal

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Optical Control of Cardiac Rhythm by In Vivo Photoactivation of an ERG Channel Peptide Inhibitor

Jérôme Montnach , Hugo Millet , Antoine Persello , Hervé Meudal , Stephan de Waard
Circulation Research, 2023, 133 (6), pp.535-538. ⟨10.1161/CIRCRESAHA.123.322880⟩
Article dans une revue hal-04225427v1
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In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

Jérôme Montnach , Laila Ananda Blömer , Ludivine Lopez , Luiza Filipis , Herve Meudal
Nature Communications, 2022, 13 (1), pp.417. ⟨10.1038/s41467-022-27974-w⟩
Article dans une revue hal-03578128v1
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DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

Kang Zhu , Marcin Suskiewicz , Andrea Hloušek-Kasun , Hervé Meudal , Andreja Mikoč
Science Advances , 2022, 8 (40), ⟨10.1126/sciadv.add4253⟩
Article dans une revue hal-03862525v1
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Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota

Noémie de San Nicolas , Aromal Asokan , Rafael D Rosa , Sébastien N Voisin , Marie-Agnès Travers
Marine drugs, 2022, 20 (12), pp.745. ⟨10.3390/md20120745⟩
Article dans une revue hal-04246173v1

Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family

Nicolas Guyot , Herve Meudal , Sascha Trapp , Sophie Iochmann , Anne Silvestre
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩
Article dans une revue hal-03609429v1
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Metabolomic Nuclear Magnetic Resonance Studies at Presymptomatic and Symptomatic Stages of Huntington’s Disease on a Drosophila Model

Marylène Bertrand , Martine Decoville , Herve Meudal , Serge Birman , Celine Landon
Journal of Proteome Research, 2020, 19 (10), pp.4034-4045. ⟨10.1021/acs.jproteome.0c00335⟩
Article dans une revue hal-02968233v1
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Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family

Nicolas Guyot , Sascha Trapp , Herve Meudal , Sophie Iochmann , Anne Silvestre
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩
Article dans une revue hal-02522250v1
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A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists

Steve Reynaud , Justyna Ciolek , Michel Degueldre , Natalie Saez , Ana Filipa Sequeira
Journal of Medicinal Chemistry, 2020, 63 (15), pp.8250-8264. ⟨10.1021/acs.jmedchem.0c00485⟩
Article dans une revue hal-02936788v1
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The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets

Karine Loth , Agnès Vergnes , Cairé Barreto , Sébastien N Voisin , Hervé Meudal
mBio, 2019, 10 (5), pii: e01821-19. ⟨10.1128/mBio.01821-19⟩
Article dans une revue hal-02328576v1

Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3

Claude Zoukimian , Hervé Meudal , Stephan de Waard , Karima Ait Ouares , Sébastien Nicolas
Bioorganic and Medicinal Chemistry, 2019, 27 (1), pp.247-253. ⟨10.1016/j.bmc.2018.12.009⟩
Article dans une revue hal-02522016v1
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The unusual resistance of avian defensin AvBD7 to proteolytic enzymes preserves its antibacterial activity

Geoffrey Bailleul , Amanda Kravtzoff , Alix Joulin-Giet , Fabien Lecaille , Valérie Labas
PLoS ONE, 2016, 11 (8), pp.1-20. ⟨10.1371/journal.pone.0161573⟩
Article dans une revue hal-01594888v1

Macrocyclic Gd(3+) Complexes with Pendant Crown Ethers Designed for Binding Zwitterionic Neurotransmitters.

Fatima Oukhatar , Hervé Meudal , Céline Landon , Nikos K Logothetis , Carlos Platas-Iglesias
Chemistry - A European Journal, 2015, 21 (31), pp.11226-11237
Article dans une revue hal-01196981v1
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Three-dimensional NMR Structure of Hen Egg Gallin (Chicken Ovodefensin) Reveals a New Variation of the β-Defensin Fold

Virginie Hervé , Hervé Meudal , Valérie Labas , Sophie Réhault-Godbert , Joël Gautron
Journal of Biological Physics and Chemistry, 2014, 289 (10), pp.7211-20. ⟨10.1074/jbc.M113.507046⟩
Article dans une revue hal-01118312v1
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Initial insights into structure-activity relationships of avian defensins.

Chrystelle Derache , Hervé Meudal , Vincent Aucagne , Kevin J Mark , Martine Cadène
Journal of Biological Chemistry, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩
Article dans une revue hal-00721842v1

Synthesis and analytical investigation of C-terminally modified peptide aldehydes and ketone: application to oxime ligation.

Corinne Buré , Philippe Marceau , Hervé Meudal , Agnès F Delmas
Journal of Peptide Science, 2012, 18 (3), pp.147-54. ⟨10.1002/psc.1429⟩
Article dans une revue hal-00721799v1

Refined solution structure and backbone dynamics of the archaeal MC1 protein

Françoise Paquet , Karine Loth , Hervé Meudal , Francoise Culard , Daniel Genest
FEBS Journal, 2010, 277 (24), pp.5133-5145. ⟨10.1111/j.1742-4658.2010.07927.x⟩
Article dans une revue hal-00602469v1
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Molecular requirements for the insecticidal activity of the plant peptide pea albumin 1 subunit b (PA1b).

Pedro da Silva , Isabelle Rahioui , Christian Laugier , Laurence Jouvensal , Hervé Meudal
Journal of Biological Chemistry, 2010, 285 (43), pp.32689-94. ⟨10.1074/jbc.M110.147199⟩
Article dans une revue hal-00591660v1

Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins

Chrystelle Derache , Valérie Labas , Vincent Aucagne , Hervé Meudal , Céline Landon
Antimicrobial Agents and Chemotherapy, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩
Article dans une revue hal-00522326v1

Synthesis and anti-HIV-1 integrase activity of modified dinucleotides

Yves Aubert , Marcel Chassignol , Victoria Roig , Gladys Mbemba , Julien Weiss
European Journal of Medicinal Chemistry, 2009, 44 (12), pp.5029-5044. ⟨10.1016/j.ejmech.2009.09.007⟩
Article dans une revue hal-00521651v1

Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes

Thomas Chauvin , Philippe Durand , Michèle Bernier , Hervé Meudal , Bich-Thuy Doan
Angewandte Chemie International Edition, 2008, 47 (23), pp.4370-4372. ⟨10.1002/anie.200800809⟩
Article dans une revue hal-00283242v1

NMR studies of telomeric nucleoprotein complexes involving the Myb-like domain of the human telomeric protein TRF2

Y. Bilbille , F. Paquet , H. Meudal , M.J. Giraud-Panis , G. Lancelot
Comptes Rendus. Chimie, 2006, 9 (3-4), pp.452-458. ⟨10.1016/j.crci.2005.06.019⟩
Article dans une revue hal-00088835v1

Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation

Céline Landon , H. Meudal , Nathalie Boulanger , Philippe Bulet , Françoise Vovelle
Biopolymers, 2006, 81 (2), pp.92-103. ⟨10.1002/bip.20370⟩
Article dans une revue hal-00088871v1

Structure of the zinc finger domain encompassing residues 13–51 of the nucleocapsid protein from simian immunodeficiency virus

Nelly Morellet , Hervé Meudal , Serge Bouaziz , Bernard Pierre Roques
Biochemical Journal, 2006, 393 (3), pp.725-732. ⟨10.1042/BJ20051203⟩
Article dans une revue hal-02122534v1

Development of Potent Inhibitors of Botulinum Neurotoxin Type B

Christine Anne , Serge Turcaud , Jean Quancard , Franck Teffo , Hervé Meudal
Journal of Medicinal Chemistry, 2003, 46 (22), pp.4648-4656. ⟨10.1021/jm0300680⟩
Article dans une revue hal-02122278v1

Thio-derived disulfides as potent inhibitors of botulinum neurotoxin type B: implications for zinc interaction.

Christine Anne , Armand Blommaert , Serge Turcaud , Anne-Sophie Martin , Hervé Meudal
Bioorganic and Medicinal Chemistry, 2003, 11 (21), pp.4655-60
Article dans une revue hal-02122201v1

Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).

Nicolas Inguimbert , Pascale Coric , Hervé Poras , Hervé Meudal , Franck Teffot
Journal of Medicinal Chemistry, 2002, 45 (7), pp.1477-86
Article dans une revue hal-02122182v1

Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.

H Chen , F Noble , A Mothé , H Meudal , P Coric
Journal of Medicinal Chemistry, 2000, 43 (7), pp.1398-408
Article dans une revue hal-02122153v1

Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode.

B Bellier , M. Million , S Danascimento , H. Meudal , S Kellou
Journal of Medicinal Chemistry, 2000, 43 (20), pp.3614-23
Article dans une revue hal-02122170v1

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Christelle David , Laurent Bischoff , Hervé Meudal , Aurélie Mothé , Nadia de Mota
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Article dans une revue hal-02122148v1

Metallopeptidase Inhibitors of Tetanus Toxin: A Combinatorial Approach

Loïc M Martin , Fabrice Cornille , Serge Turcaud , Hervé Meudal , Bernard P. Roques
Journal of Medicinal Chemistry, 1999, 42 (3), pp.515-525. ⟨10.1021/jm981066w⟩
Article dans une revue hal-02528535v1

Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Christelle David , Laurent Bischoff , Hervé Meudal , Aurélie Mothé , Nadia de Mota
Journal of Medicinal Chemistry, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩
Article dans une revue hal-02385508v1

Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.

S Druillennec , H Meudal , B.P Roques , M.C Fournié-Zaluski
Bioorganic and Medicinal Chemistry Letters, 1999, 9 (4), pp.627-32
Article dans une revue hal-02122144v1

Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.

B Bellier , S da Nascimento , H. Meudal , E. Gincel , B.P Roques
Bioorganic and Medicinal Chemistry Letters, 1998, 8 (11), pp.1419-24
Article dans une revue hal-02122133v1

2,4-Dinitrophenyl 4-Methoxybenzyl Disulfide: A New Efficient Reagent for the Electrophilic Sulfenylation of β-Amino Ester Enolates

Laurent Bischoff , Christelle David , Loïc M Martin , Hervé Meudal , Bernard-Pierre Roques
Journal of Organic Chemistry, 1997, 62 (14), pp.4848-4850. ⟨10.1021/jo9623853⟩
Article dans une revue hal-02122111v1

Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Christelle David , Laurent Bischoff , Hervé Meudal , Catherine Llorens-Cortes , Bernard Pierre Roques
Letters in Peptide Science, 1997, 4 (4/6), pp.411-414. ⟨10.1023/A:1008894115205⟩
Article dans une revue hal-02122127v1

Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of Two Affinity States of the CCK-B Receptor on Transfected CHO Cells

Bruno Bellier , Isabelle Mccort , Bertrand Ducos , Sophie Danascimento , Hervé Meudal
Journal of Medicinal Chemistry, 1997, 40 (24), pp.3947-3956. ⟨10.1021/jm970439a⟩
Article dans une revue hal-02122116v1

Optimal Recognition of Neutral Endopeptidase and Angiotensin-Converting Enzyme Active Sites by Mercaptoacyldipeptides as a Means To Design Potent Dual Inhibitors

Pascale Coric , Serge Turcaud , Hervé Meudal , Bernard Pierre Roques , Marie-Claude Fournie-Zaluski
Journal of Medicinal Chemistry, 1996, 39 (6), pp.1210-1219. ⟨10.1021/jm950590p⟩
Article dans une revue hal-02122055v1

Synthesis of constrained 4-(phosphonomethyl)phenylalanine derivatives as hydrolytically stable analogs of O-phosphotyrosine

Wang-Qing Liu , François Carreaux , Hervé Meudal , Bernard P. Roques , Christiane Garbay-Jaureguiberry
Tetrahedron, 1996, 52 (12), pp.4411-4422. ⟨10.1016/0040-4020(96)00085-3⟩
Article dans une revue hal-02122054v1

Design of Orally Active Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme with Long Duration of Action

Marie-Claude Fournie-Zaluski , Pascale Coric , Vincent Théry , Walter D Gonzalez , Hervé Meudal
Journal of Medicinal Chemistry, 1996, 39 (13), pp.2594-2608. ⟨10.1021/jm950783c⟩
Article dans une revue hal-02122108v1

Investigation of the structural parameters involved in the delta-opioid selectivity of several families of opioid peptides.

C Guis , L Bruetschy , H. Meudal , B. Roques , G Gacel
International Journal of Peptide and Protein Research, 1993, 41 (6), pp.576-86
Article dans une revue hal-02122053v1

Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 3

A. Asokan , Noémie de San Nicolas , H. Meudal , K. Loth , Delphine Destoumieux-Garzon
22nd GFPP / BPGM5 French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France
Communication dans un congrès hal-03976595v1

Gga-AvBD11, the archetype of a new structural family of defensins

H. Meudal , Nicolas Guyot , K. Loth , G. Jousset , S. Trapp
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès hal-02892790v1

1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles

Nicolas Guyot , Hervé Meudal , Karine Loth , Guillaume Jousset , Anne Silvestre
5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France
Communication dans un congrès hal-02788993v1

Metabolomic NMR studies & Huntington’s disease: models in transgenic drosophila

Marylène Bertrand , H. Meudal , S. Birman , M. Decoville , C. Landon
Conférence SMMAP 2017 - Conférence de Spectrométrie de Masse, Métabolomique et Fluxomique & Electrophorèse et Analyse Protéomique, Oct 2017, Marne-la-Vallée, France
Communication dans un congrès hal-02919162v1

Functional and structural characterization of egg defensins

Nicolas Guyot , Virginie Herve , Hervé Meudal , Jean-Baptiste Madinier , Valérie Labas
Banff Egg Forum, Jun 2014, Wroclaw, Poland. 12 diapositives
Communication dans un congrès hal-02797356v1

Insights into the structure-function relationship of egg defensins

Nicolas Guyot , Virginie Hervé , Hervé Meudal , Jean-Baptiste Madinier , Valérie Labas
XIVth European Poultry Conference, World's Poultry Science Association (WPSA). INT., Jun 2014, Stavanger, Norway
Communication dans un congrès hal-02743609v1

1ère défensine d'oeuf : caractérisation, synthèse, structure

H. Meudal , Virginie Herve-Grepinet , Valérie Labas , A. Delmas , Yves Y. Nys
22. Congrès de la Société Française de Biophysique, Sep 2010, La Colle-sur-Loup, France
Communication dans un congrès hal-02757482v1

Cys-containing functional miniproteins: synthesis and oxidative folding.

C Derache , H Meudal , V Aucagne , Anne-Christine Lalmanach , C Landon
2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France
Communication dans un congrès hal-02751660v1

First insights into the structure-activity relationships of avian beta-defensins.

Chrystelle Derache , Hervé Meudal , Vincent Aucagne , Martine Cadène , Agnès Delmas
2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France
Communication dans un congrès hal-02753345v1

1ère structure 3D d'une défensine antibactérienne de poulet

C Derache , H Meudal , V Aucagne , M Cadène , A Delmas
21e Colloque Biotechnocentre, 2008, Seillac, France
Communication dans un congrès hal-02752777v1