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Isabelle Fournier

Professor Senior Member Institut Universitaire de France Vice President for Doctoral Research at University of Lille
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Présentation

Prof. Fournier is Distinguished Professor at University of Lille, and she holds a position as co-director of the PRISM Inserm U1192 Lab and as Vice President for Doctoral Research for the university. She is a bioanalytical chemist specialized in clinical mass spectrometry and proteomics. She started research working on fundamental of MALDI during her PhD at University Pierre & Marie Curie in Paris first and then, as a postdoctoral fellow within the group of Prof. Michael Karas in Frankfurt. In 2002, she established her own group at University of Lille where she started developing MALDI MS Imaging. She contributed to the field with several developments including strategies for imaging of FFPE tissues and proteins, and the development of tagged probes for specific imaging of mRNA and antigens. In 2009, she was hired as Full Professor and awarded a Junior position at Institut Universitaire de France. Since 2012, she got interested by the development of Spatially Resolved Proteomics in combination to MALDI MSI for applications in oncology. Over the past 5 years, she also worked on the development of in vivo MS for guided surgery and intraoperative analysis. She confounded the Imabiotech Company which provides services in MALDI MSI and recently CELEOS that will commercialize the SpiderMass technology. She was recently distinguished by the international distinguish award from MSACL and was awarded a senior position at Institut Universitaire de France in 2019.

Domaines de recherche

Chimie analytique Génomique, Transcriptomique et Protéomique [q-bio.GN] Imagerie

Compétences

mass spectrometry imaging proteomics spatial proteomics lipidomics health technology

Publications

"franck-rodet"
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Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome.

Alice Capuz , Sylvain Osien , Tristan Cardon , Melodie-Anne Karnoub , Soulaimane Aboulouard
Cell Death Dis, 2023, Cell Death Dis, 14, pp.526. ⟨10.1038/s41419-023-06037-y⟩
Article dans une revue hal-04400988v1

Correction: Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome

Alice Capuz , Sylvain Osien , Tristan Cardon , Mélodie Anne Karnoub , Soulaimane Aboulouard
Cell Death and Disease, 2023, 14 (10), pp.677. ⟨10.1038/s41419-023-06143-x⟩
Article dans une revue hal-04278155v1

The Antibody Dependant Neurite Outgrowth Modulation Response Involvement in Spinal Cord Injury

Alice Capuz , Mélodie-Anne Karnoub , Sylvain Osien , Mélanie Rose , Céline Mériaux
Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.882830⟩
Article dans une revue hal-04278167v1
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Therapeutic anti-glioma effect of the combined action of pcsk inhibitor with the anti-tumoral factors secreted by poly (i:c)-stimulated macrophages

Melanie Rose , Marie Duhamel , Soulaimane Aboulouard , Firas Kobeissy , Dominique Tierny
Cancer Gene Therapy, 2021, Cancer Gene Therapy, 29, pp.22-36. ⟨10.1038/s41417-020-00286-1⟩
Article dans une revue hal-04009706v1

Epigenetic Studies Revealed a Ghost Proteome in PC1/3 KD Macrophages under Antitumoral Resistance Induced by IL-10

Tristan Cardon , Bilgehan Ozcan , Soulaimane Aboulouard , Firas Kobeissy , Marie Duhamel
Article dans une revue hal-04445712v1
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The Role of a Proprotein Convertase Inhibitor in Reactivation of Tumor-Associated Macrophages and Inhibition of Glioma Growth

Mélanie Rose , Marie Duhamel , Soulaimane Aboulouard , Firas Kobeissy , Emilie Le Rhun
Molecular Therapy - Oncolytics, 2020, 17, pp.31-46. ⟨10.1016/j.omto.2020.03.005⟩
Article dans une revue inserm-02940430v1
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3D MALDI mass spectrometry imaging reveals specific localization of long-chain acylcarnitines within a 10-day time window of spinal cord injury

Jusal Quanico , Lena Hauberg-Lotte , Stephanie Devaux , Zahra Laouby , Celine Meriaux
Scientific Reports, 2018, 8 (1), pp.16083. ⟨10.1038/s41598-018-34518-0⟩
Article dans une revue inserm-02940797v1

Paclitaxel Treatment and Proprotein Convertase 1/3 (PC1/3) Knockdown in Macrophages is a Promising Antiglioma Strategy as Revealed by Proteomics and Cytotoxicity Studies

Marie Duhamel , Mélanie Rose , Franck Rodet , Adriana Natalia Murgoci , Lea Zografidou
Molecular and Cellular Proteomics, 2018, 17 (6), pp.1126-1143. ⟨10.1074/mcp.RA117.000443⟩
Article dans une revue hal-01847515v1

Deciphering molecular consequences of the proprotein convertase 1/3 inhibition in macrophages for application in anti-tumour immunotherapy

Franck Rodet , Alice Capuz , Tsukasa Hara , Rinaldo van Meel , Marie Duhamel
Journal of Biotechnology, 2018, 282, pp.80-85. ⟨10.1016/j.jbiotec.2018.07.002⟩
Article dans une revue hal-04445717v1

Shedding new light on spinal cord injury

Michel Salzet , Jusal Quanico , Dasa Cizkova , Melodie Anne Karnoub , Zarha Laouby
Journal of Biotechnology, 2018, 280, pp.S4. ⟨10.1016/j.jbiotec.2018.06.314⟩
Article dans une revue inserm-02940788v1

Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages

Marie Duhamel , Franck Rodet , Adriana Murgoci , Maxence Wisztorski , Robert Day
EuPA Open Proteomics, 2016, 11, pp.20-22. ⟨10.1016/j.euprot.2016.03.003⟩
Article dans une revue hal-04447345v1

The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways

M. Duhamel , F. Rodet , A. Murgoci , R. Desjardins , H. Gagnon
Scientific Reports, 2016, 6 (1), pp.19360. ⟨10.1038/srep19360⟩
Article dans une revue hal-04445727v1
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The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways

M. Duhamel , F. Rodet , A. Murgoci , R. Desjardins , H. Gagnon
Scientific Reports, 2016, 6, pp.19360. ⟨10.1038/srep19360⟩
Article dans une revue inserm-02940434v1
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Reciprocal immune benefit based on complementary production of antibiotics by the leech Hirudo verbana and its gut symbiont Aeromonas veronii

Aurélie Tasiemski , François Massol , Virginie Cuvillier-Hot , Céline Boidin-Wichlacz , Emmanuel Roger
Scientific Reports, 2015, 5, pp.17498. ⟨10.1038/srep17498⟩
Article dans une revue hal-01239548v1

Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study

M. Duhamel , F. Rodet , N. Delhem , F. Vanden Abeele , F. Kobeissy
Molecular and Cellular Proteomics, 2015, 14 (11), pp.2857-77. ⟨10.1074/mcp.M115.052480⟩
Article dans une revue hal-01850616v1