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A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection
Xue Liu
,
Laurye van Maele
,
Laura Matarazzo
,
Daphnée Soulard
,
Vinicius Alves Duarte da Silva
Journal articles
inserm-04605118v1
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|
Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia
Mara Baldry
,
Yasmine Zeroual
,
Delphine Cayet
,
Jeoffrey Pardessus
,
Daphne Soulard
Antimicrobial Agents and Chemotherapy, 2024, Antimicrobial Agents and Chemotherapy, 68 (12), pp.e0086624. ⟨10.1128/aac.00866-24⟩
Journal articles
hal-04840787v1
|
|
Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance
Charlotte Costa
,
Jean-Claude Sirard
,
Paddy Gibson
,
Jan-Willem Veening
,
Erida Gjini
Journal articles
inserm-04605101v1
|
|
Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa
Ana Raquel Maia
,
Adeline Cezard
,
Delphine Fouquenet
,
Virginie Vasseur
,
Benoit Briard
Journal articles
hal-04683300v1
|
|
Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity
Mélanie Mondemé
,
Christophe Carnoy
,
Jean-Claude Sirard
,
Christelle Faveeuw
Journal articles
hal-04238526v1
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Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence
Vikrant Minhas
,
Arnau Domenech
,
Dimitra Synefiaridou
,
Daniel Straume
,
Max Brendel
Journal articles
hal-04462466v1
|
|
Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function.
Melanie Mondeme
,
Yasmine Zeroual
,
Daphne Soulard
,
Benjamin Hennart
,
Delphine Beury
Journal articles
hal-04474406v1
|
|
Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells
Christine van Linge
,
Katina Hulme
,
Hessel Peters-Sengers
,
Jean-Claude Sirard
,
Wil Goessens
Journal articles
hal-04462460v1
|
|
Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq
Liselot Dewachter
,
Julien Dénéréaz
,
Xue Liu
,
Vincent de Bakker
,
Charlotte Costa
Journal articles
hal-04462473v1
|
|
TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium
Isabelle Fleurot
,
Raquel López-Gálvez
,
Pascal Barbry
,
Antoine Guillon
,
Mustapha Si-Tahar
Journal articles
hal-03556846v1
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The Biosynthetic Monophosphoryl Lipid A Enhances the Therapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia.
Fiordiligie Casilag
,
Laura Matarazzo
,
Sebastian Franck
,
Martin Figeac
,
Robin Michelet
Journal articles
inserm-03288018v1
|
|
Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa
Raquel López-Gálvez
,
Isabelle Fleurot
,
Pablo Chamero
,
Sascha Trapp
,
Olivier Michel
Journal articles
hal-03258174v1
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|
A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice
Sebastian Franck
,
Robin Michelet
,
Fiordiligie Casilag
,
Jean Claude Sirard
,
Sebastian G. Wicha
Journal articles
hal-03258185v1
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|
Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice
Thomas Belcher
,
Hana Kammoun
,
Loïc Coutte
,
Anne-Sophie Debrie
,
Nathalie Mielcarek
Journal articles
hal-03372774v1
|
|
mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin
I. Ramirez-Moral
,
X. Yu
,
J. M. Butler
,
M. van Weeghel
,
N. A. Otto
Journal articles
hal-03258194v1
|
|
The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice
Magdiel Pérez-Cruz
,
Bachirou Koné
,
Rémi Porte
,
Christophe Carnoy
,
Julien Tabareau
Journal articles
hal-03258191v1
|
|
The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia
Robin Michelet
,
Moreno Ursino
,
Sandrine Boulet
,
Sebastian Franck
,
Fiordiligie Casilag
Journal articles
hal-03215662v1
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|
Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
Claire Mackowiak
,
Tiffany Marchiol
,
Hana Cipcic Paljetak
,
Louis Fauconnier
,
Jennifer Palomo
Journal articles
hal-03429701v1
|
|
Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
Claire Mackowiak
,
Tiffany Marchiol
,
Hana Cipcic Paljetak
,
Louis Fauconnier
,
Jennifer Palomo
Journal articles
hal-03258180v1
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|
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection
Wanhai Qin
,
Xanthe Brands
,
Cornelis Van’t Veer
,
Alex F. de Vos
,
Jean Claude Sirard
Journal articles
hal-03258188v1
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|
Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae
Robin A. Sorg
,
Clement Gallay
,
Laurye van Maele
,
Jean Claude Sirard
,
Jan-Willem Veening
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (44), pp.27608-27619. ⟨10.1073/pnas.1920015117⟩
Journal articles
hal-03258211v1
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The GM-CSF released by airway epithelial cells orchestrates the mucosal adjuvant activity of flagellin
Aneesh Vijayan
,
Laurye van Maele
,
Delphine Fougeron
,
Delphine Cayet
,
Jean Claude Sirard
Journal of Immunology, 2020, pp.ji2000746
Journal articles
inserm-02957765v1
|
|
Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01
Laurye van Maele
,
Delphine Fougeron
,
Delphine Cayet
,
Aurélie Chalon
,
Diego Piccioli
Journal articles
inserm-02398403v1
|
|
Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants
Marina Elizabeth Biedma
,
Delphine Cayet
,
Julien Tabareau
,
Andrés Rossi
,
Karolina Ivičak-Kocjan
Journal articles
inserm-02078833v1
|
|
A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume
Sebastian Franck
,
Tania Fuhrmann-Selter
,
Jan Joseph
,
Robin Michelet
,
Fiordiligie Casilag
Journal articles
inserm-02144087v1
|
|
Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir
Anne-France Georgel
,
Delphine Cayet
,
Andrés Pizzorno
,
Manuel Rosa-Calatrava
,
Christophe Paget
Journal articles
inserm-02144074v1
|
|
Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4
Anne-Sophie Debrie
,
Nathalie Mielcarek
,
Sophie Lecher
,
Xavier Roux
,
Jean Claude Sirard
Journal articles
inserm-02398404v1
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|
Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia
Laura Matarazzo
,
Fiordiligie Casilag
,
Rémi Porte
,
Frederic Wallet
,
Delphine Cayet
Journal articles
inserm-02144080v1
|
|
Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation
Fabien Bastaert
,
Saadé Kheir
,
Vinciane Saint-Criq
,
Bérengère Villeret
,
Pham My-Chan Dang
Journal articles
inserm-02078851v1
|
|
Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection
Ranin Beshara
,
Valentin Sencio
,
Daphnée Soulard
,
Adeline Barthélémy
,
Josette Fontaine
Journal articles
inserm-02078841v1
|
|
Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae
Khalil Farhat
,
Gwennaëlle Bodart
,
Chantal Charlet-Renard
,
Christophe Desmet
,
Michel Moutschen
Journal articles
inserm-02078849v1
|
|
Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.
Rémi Porte
,
Laurye van Maele
,
Natalia Muñoz-Wolf
,
Benoit Foligné
,
Laure Dumoutier
Journal articles
inserm-01529315v1
|
|
Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Catherine Sabatel
,
Coraline Radermecker
,
Laurence Fievez
,
Genevieve Paulissen
,
Svetoslav Chakarov
Journal articles
inserm-01529380v1
|
|
Compartmentalized Antimicrobial Defenses in Response to Flagellin
Aneesh Vijayan
,
Martin Rumbo
,
Christophe Carnoy
,
Jean-Claude Sirard
Journal articles
inserm-01671191v1
|
|
Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.
Agustina Errea
,
Delphine Cayet
,
Philippe Marchetti
,
Cong Tang
,
Jerome Kluza
Journal articles
inserm-01529298v1
|
|
Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model.
Carolina Iraporda
,
David E Romanin
,
Ana A Bengoa
,
Agustina J Errea
,
Delphine Cayet
Journal articles
inserm-01529366v1
|
|
Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.
Natalia Muñoz-Wolf
,
Analía Rial
,
Delphine Fougeron
,
Julien Tabareau
,
Jean-Claude Sirard
Journal articles
inserm-01529275v1
|
|
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
Magdalena Matusiak
,
Nina van Opdenbosch
,
Lieselotte Vande Walle
,
Jean-Claude Sirard
,
Thirumala-Devi Kanneganti
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (5), pp.1541-1546. ⟨10.1073/pnas.1417945112⟩
Journal articles
inserm-01182904v1
|
|
Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells.
Agathe Goubard
,
Caroline Loïez
,
Jun Abe
,
Caroline Fichel
,
Stéphanie Herwegh
Journal articles
inserm-01182906v1
|
|
Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract
Delphine Fougeron
,
Laurye van Maele
,
Pascal Songhet
,
Delphine Cayet
,
David Hot
Journal articles
inserm-01182907v1
|
|
A toll-like receptor 5 agonist improves the efficacy of antibiotics in the treatment of primary and influenza-associated pneumococcal mouse infections.
Rémi Porte
,
Delphine Fougeron
,
Natalia Muñoz-Wolf
,
Julien Tabareau
,
Anne-France Georgel
Journal articles
inserm-01182908v1
|
|
Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response.
Martina Crispo
,
Laurye van Maele
,
Julien Tabareau
,
Delphine Cayet
,
Agustina Errea
Journal articles
inserm-00925644v1
|
|
In vivo germination of Bacillus anthracis spores during murine cutaneous infection.
Jean-Philippe Corre
,
Alejandro Piris-Gimenez
,
Marie Moya-Nilges
,
Gregory Jouvion
,
Agnes Fouet
Journal articles
inserm-00926617v1
|
|
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.
Laurye van Maele
,
Delphine Fougeron
,
Laure Janot
,
Arnaud Didierlaurent
,
Delphine Cayet
Journal articles
inserm-00925663v1
|
|
Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.
Stoyan Ivanov
,
Joelle Renneson
,
Josette Fontaine
,
Adeline Barthelemy
,
Christophe Paget
Journal articles
inserm-00926618v1
|
|
Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection.
Griselda Moreno
,
Agustina Errea
,
Laurye van Maele
,
Roy Roberts
,
Hélène Léger
Journal articles
inserm-00925669v1
|
|
The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.
Maria L. Knudsen
,
Daniel X. Johansson
,
Linda Kostic
,
Eva K. L. Nordström
,
Karin Tegerstedt
Journal articles
inserm-00925649v1
|
|
NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.
Boas Felmy
,
Pascal Songhet
,
Emma Marie Caroline Slack
,
Andreas J. Müller
,
Marcus Kremer
Journal articles
inserm-00925654v1
|
|
Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity.
Juan M. Marqués
,
Analía Rial
,
Natalia Muñoz
,
Francois-Xavier Pellay
,
Laurye van Maele
Journal articles
inserm-00926614v1
|
|
Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide.
Stoyan Ivanov
,
Josette Fontaine
,
Christophe Paget
,
Elodie Macho Fernandez
,
Laurye van Maele
Journal articles
inserm-00926616v1
|
|
IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.
Laure Dumoutier
,
Magali de Heusch
,
Ciriana Orabona
,
Naoko Satoh-Takayama
,
Gerard Eberl
Journal articles
inserm-00926611v1
|
|
IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium.
Pascal Songhet
,
Manja Barthel
,
Till A Röhn
,
Laurye van Maele
,
Delphine Cayet
Journal articles
inserm-00926613v1
|
|
The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea.
Kathrin Endt
,
Bärbel Stecher
,
Samuel Chaffron
,
Emma Slack
,
Nicolas Tchitchek
Journal articles
inserm-00520162v1
|
|
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.
Laurye van Maele
,
Christophe Carnoy
,
Delphine Cayet
,
Pascal Songhet
,
Laure Dumoutier
Journal articles
inserm-00495564v1
|
|
The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells
Céline Beauvillain
,
Francesca Meloni
,
Jean-Claude Sirard
,
Simon Blanchard
,
Ulrich Jarry
Journal articles
inserm-00926610v1
|
|
Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.
Natalia Munoz
,
Laurye van Maele
,
Juan Marqués
,
Analia Rial
,
Jean-Claude Sirard
Journal articles
inserm-00520159v1
|
|
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
Laure Janot
,
Jean-Claude Sirard
,
Thomas Secher
,
Nicolas Noulin
,
Lizette Fick
Journal articles
inserm-00385299v1
|
|
Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics.
Jean-Claude Sirard
,
Arnaud Didierlaurent
,
Delphine Cayet
,
Frédéric Sierro
,
Martin Rumbo
Journal articles
inserm-00385296v1
|
|
Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.
Clément Nempont
,
Delphine Cayet
,
Martin Rumbo
,
Coralie Bompard
,
Vincent Villeret
Journal articles
inserm-00309796v1
|
|
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.
Arnaud Didierlaurent
,
John Goulding
,
Seema Patel
,
Robert Snelgrove
,
Lionel Low
Journal articles
inserm-00227540v1
|
|
Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.
Aizhen Guo
,
Melissa A. Lasaro
,
Jean-Claude Sirard
,
Jean-Pierre Kraehenbuhl
,
Dieter M. Schifferli
Journal articles
inserm-00177727v1
|
|
A key role of dendritic cells in probiotic functionality.
Benoit Foligne
,
Georgia Zoumpopoulou
,
Joelle Dewulf
,
Amena Ben Younes
,
Fabrice Chareyre
Journal articles
inserm-00177781v1
|
|
Nod-like receptors: cytosolic watchdogs for immunity against pathogens.
Jean-Claude Sirard
,
Cécile Vignal
,
Rodrigue Dessein
,
Mathias Chamaillard
Journal articles
inserm-00223906v1
|
|
Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.
Rachel A. Luu
,
Komal Gurnani
,
Renu Dudani
,
Rajagopal Kammara
,
Henk van Faassen
Journal articles
inserm-00177783v1
|
|
Pathogen-specific TLR signaling in mucosa: mutual contribution of microbial TLR agonists and virulence factors.
Jean-Claude Sirard
,
Mariela Bayardo
,
Arnaud Didierlaurent
Journal articles
inserm-00000042v1
|
|
Mucosal interplay among commensal and pathogenic bacteria: lessons from flagellin and Toll-like receptor 5.
Martin Rumbo
,
Clément Nempont
,
Jean-Pierre Kraehenbuhl
,
Jean-Claude Sirard
Journal articles
inserm-00071278v1
|
|
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.
Marie Le Borgne
,
Nathalie Etchart
,
Anne Goubier
,
Sergio A. Lira
,
Jean Claude Sirard
Journal articles
inserm-00000041v1
|
|
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.
Arnaud Didierlaurent
,
Brian Brissoni
,
Dominique Velin
,
Natalia Aebi
,
Aubry Tardivel
Journal articles
inserm-00000043v1
|
|
Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells.
Martin Rumbo
,
Françoise Courjault-Gautier
,
Frédéric Sierro
,
Jean-Claude Sirard
,
Emanuela Felley-Bosco
Journal articles
inserm-00000045v1
|
|
Innate and acquired plasticity of the intestinal immune system.
Arnaud Didierlaurent
,
Michel Simonet
,
Jean-Claude Sirard
Journal articles
inserm-00000044v1
|
|
Interaction of pathogenic bacteria with rabbit appendix M cells: bacterial motility is a key feature in vivo
Marta Marchetti
,
Jean Claude Sirard
,
Philippe Sansonetti
,
Eric Pringault
,
Sophie Kerneis
Journal articles
hal-02675770v1
|
|
Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa.
Hugo Cruz Ramos
,
Martin Rumbo
,
Jean-Claude Sirard
Journal articles
inserm-00000046v1
|
|
How the gut links innate and adaptive immunity.
Martin Rumbo
,
Pascale Anderle
,
Arnaud Didierlaurent
,
Frédéric Sierro
,
Nathalie Debard
Journal articles
inserm-00223904v1
|