Jean-Claude Sirard

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Affiliation actuelle

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL)

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Publications

Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia

Laura Matarazzo , Charlotte Costa , Rémi Porte , Jean-Michel Saliou , Martin Figeac et al.

Mucosal Immunology, 2025, 18 (1), pp.257-268. ⟨10.1016/j.mucimm.2024.11.009⟩

Article dans une revue inserm-05340629v1

Impaired K48-polyubiquitination downmodulates mouse norovirus propagation

Emmrich Wakeford , Elisabeth Werkmeister , Delphine Cayet , Sabine Poiret , Catherine Daniel et al.

Frontiers in Cellular and Infection Microbiology, 2025, Frontiers in Cellular and Infection Microbiology, 15, pp.1530166. ⟨10.3389/fcimb.2025.1530166⟩

Article dans une revue hal-05280293v1

Physicochemical stability of a polysorbate-80-containing solvent compounded in the hospital pharmacy and used to reconstitute a biologic for nebulisation

Laura Négrier , Marine Roche , Damien Lannoy , Christophe Berneron , Léa Pacqueu et al.

European Journal of Hospital Pharmacy, 2025, ejhpharm-2024-004441. ⟨10.1136/ejhpharm-2024-004441⟩

Article dans une revue hal-05500268v1

Flagellin nebulization enhances respiratory immune responses in the porcine model

Mara Baldry , Ignacio Caballero , Lisette Ruuls , Delphine Cayet , Yasmine Zeroual et al.

iScience, 2025, 28 (12), pp.114218. ⟨10.1016/j.isci.2025.114218⟩

Article dans une revue hal-05390732v1

Physicochemical stability of a polysorbate-80-containing solvent compounded in the hospital pharmacy and used to reconstitute a biologic for nebulisation.

Laura Negrier , Marine Roche , Damien Lannoy , C. Berneron , L. Pacqueu et al.

European Journal of Hospital Pharmacy, 2025, Eur J Hosp Pharm, ⟨10.1136/ejhpharm-2024-004441⟩

Article dans une revue hal-05043532v1

Topical adjunctive treatment with flagellin augments pulmonary neutrophil responses and reduces bacterial dissemination in multidrug-resistant K. pneumoniae infection

Christine van Linge , Robert F.J. Kullberg , Osoul Chouchane , Joris Roelofs , Wil Goessens et al.

Frontiers in Immunology, 2024, 15, pp.1450486. ⟨10.3389/fimmu.2024.1450486⟩

Article dans une revue inserm-05340825v1

Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance

Charlotte Costa , Jean-Claude Sirard , Paddy Gibson , Jan-Willem Veening , Erida Gjini et al.

Journal of Infectious Diseases, 2024, pp.jiae239. ⟨10.1093/infdis/jiae239⟩

Article dans une revue inserm-04605101v1

A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection

Xue Liu , Laurye van Maele , Laura Matarazzo , Daphnée Soulard , Vinicius Alves Duarte da Silva et al.

Cell Host & Microbe, 2024, 32 (3), pp.304-314.e8. ⟨10.1016/j.chom.2024.02.002⟩

Article dans une revue inserm-04605118v1

Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa

Ana Raquel Maia , Adeline Cezard , Delphine Fouquenet , Virginie Vasseur , Benoit Briard et al.

Antimicrobial Agents and Chemotherapy, 2024, 68 (5), pp.e01361-23. ⟨10.1128/aac.01361-23⟩

Article dans une revue hal-04683300v1

Targeted delivery of flagellin by nebulization offers optimized respiratory immunity and defense against pneumococcal pneumonia

Mara Baldry , Charlotte Costa , Yasmine Zeroual , Delphine Cayet , Jeoffrey Pardessus et al.

Antimicrobial Agents and Chemotherapy, 2024, 68 (12), pp.e0086624. ⟨10.1128/aac.00866-24⟩

Article dans une revue inserm-05340634v1

Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells

Christine van Linge , Katina Hulme , Hessel Peters-Sengers , Jean-Claude Sirard , Wil Goessens et al.

International Journal of Molecular Sciences, 2023, 25 (1), pp.309. ⟨10.3390/ijms25010309⟩

Article dans une revue hal-04462460v1

Amoxicillin treatment of pneumococcal pneumonia impacts bone marrow neutrophil maturation and function.

Melanie Mondeme , Yasmine Zeroual , Daphne Soulard , Benjamin Hennart , Delphine Beury et al.

Journal of Leukocyte Biology, 2023, Journal of Leukocyte Biology, 115 (3), pp.463-475. ⟨10.1093/jleuko/qiad125⟩

Article dans une revue hal-04474406v1

Treatment of Bacterial Infections with β-Lactams: Cooperation with Innate Immunity

Mélanie Mondemé , Christophe Carnoy , Jean-Claude Sirard , Christelle Faveeuw

Infection and Immunity, 2023, 91 (2), pp.e00503-22. ⟨10.1128/iai.00503-22⟩

Article dans une revue (article de synthèse) hal-04238526v1

Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence

Vikrant Minhas , Arnau Domenech , Dimitra Synefiaridou , Daniel Straume , Max Brendel et al.

PLoS Biology, 2023, 21 (1), pp.e3001990. ⟨10.1371/journal.pbio.3001990⟩

Article dans une revue hal-04462466v1

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

Liselot Dewachter , Julien Dénéréaz , Xue Liu , Vincent de Bakker , Charlotte Costa et al.

eLife, 2022, 11, ⟨10.7554/eLife.75607⟩

Article dans une revue hal-04462473v1

TLR5 signalling is hyper-responsive in porcine cystic fibrosis airways epithelium

Isabelle Fleurot , Raquel López-Gálvez , Pascal Barbry , Antoine Guillon , Mustapha Si-Tahar et al.

Journal of Cystic Fibrosis, 2022, 21 (2), pp.e117-e121. ⟨10.1016/j.jcf.2021.08.002⟩

Article dans une revue hal-03556846v1

The Use of Translational Modelling and Simulation to Develop Immunomodulatory Therapy as an Adjunct to Antibiotic Treatment in the Context of Pneumonia

Robin Michelet , Moreno Ursino , Sandrine Boulet , Sebastian Franck , Fiordiligie Casilag et al.

Pharmaceutics, 2021, 13 (5), pp.601. ⟨10.3390/pharmaceutics13050601⟩

Article dans une revue hal-03215662v1

A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice

Sebastian Franck , Robin Michelet , Fiordiligie Casilag , Jean Claude Sirard , Sebastian G. Wicha et al.

Pharmaceutics, 2021, 13 (4), pp.1-12. ⟨10.3390/pharmaceutics13040469⟩

Article dans une revue hal-03258185v1

The Biosynthetic Monophosphoryl Lipid A Enhances the Therapeutic Outcome of Antibiotic Therapy in Pneumococcal Pneumonia.

Fiordiligie Casilag , Laura Matarazzo , Sebastian Franck , Martin Figeac , Robin Michelet et al.

ACS Infectious Diseases, 2021, Online ahead of print. ⟨10.1021/acsinfecdis.1c00176⟩

Article dans une revue inserm-03288018v1

Airway administration of flagellin regulates the inflammatory response to Pseudomonas aeruginosa

Raquel López-Gálvez , Isabelle Fleurot , Pablo Chamero , Sascha Trapp , Olivier Michel et al.

American Journal of Respiratory Cell and Molecular Biology, 2021, 65 (4), pp.378-389. ⟨10.1165/rcmb.2021-0125OC⟩

Article dans une revue hal-03258174v1

mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

I. Ramirez-Moral , X. Yu , J. M. Butler , M. van Weeghel , N. A. Otto et al.

Mucosal Immunology, 2021, 14 (3), pp.594-604. ⟨10.1038/s41385-021-00377-8⟩

Article dans une revue hal-03258194v1

The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice

Magdiel Pérez-Cruz , Bachirou Koné , Rémi Porte , Christophe Carnoy , Julien Tabareau et al.

PLoS ONE, 2021, 16 (3), ⟨10.1371/journal.pone.0236216⟩

Article dans une revue hal-03258191v1

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

Wanhai Qin , Xanthe Brands , Cornelis Van’t Veer , Alex F. de Vos , Jean Claude Sirard et al.

PLoS Pathogens, 2021, 17 (4), ⟨10.1371/journal.ppat.1009491⟩

Article dans une revue hal-03258188v1

Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo et al.

ImmunoHorizons , 2021, 5 (5), pp.273-283. ⟨10.4049/immunohorizons.2000095⟩

Article dans une revue hal-03258180v1

Live attenuated Bordetella pertussis vaccine candidate BPZE1 transiently protects against lethal pneumococcal disease in mice

Thomas Belcher , Hana Kammoun , Loïc Coutte , Anne-Sophie Debrie , Nathalie Mielcarek et al.

Vaccine, In press, ⟨10.1016/j.vaccine.2021.01.025⟩

Article dans une revue hal-03372774v1

The GM-CSF released by airway epithelial cells orchestrates the mucosal adjuvant activity of flagellin

Aneesh Vijayan , Laurye van Maele , Delphine Fougeron , Delphine Cayet , Jean Claude Sirard

Journal of Immunology, 2020, pp.ji2000746

Article dans une revue inserm-02957765v1

Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae

Robin A. Sorg , Clement Gallay , Laurye van Maele , Jean Claude Sirard , Jan-Willem Veening

Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (44), pp.27608-27619. ⟨10.1073/pnas.1920015117⟩

Article dans une revue hal-03258211v1

Recombinant flagellins with deletions in domains D1, D2, and D3: Characterization as novel immunoadjuvants

Marina Elizabeth Biedma , Delphine Cayet , Julien Tabareau , Andrés Rossi , Karolina Ivičak-Kocjan et al.

Vaccine, 2019, 37 (4), pp.652-663. ⟨10.1016/j.vaccine.2018.12.009⟩

Article dans une revue inserm-02078833v1

Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4

Anne-Sophie Debrie , Nathalie Mielcarek , Sophie Lecher , Xavier Roux , Jean Claude Sirard et al.

Journal of Immunology, 2019, pp.ji1901102. ⟨10.4049/jimmunol.1901102⟩

Article dans une revue inserm-02398404v1

Toll-like receptor 5 agonist flagellin reduces influenza A virus replication independently of type I interferon and interleukin 22 and improves antiviral efficacy of oseltamivir

Anne-France Georgel , Delphine Cayet , Andrés Pizzorno , Manuel Rosa-Calatrava , Christophe Paget et al.

Antiviral Research, 2019, 168, pp.28-35. ⟨10.1016/j.antiviral.2019.05.002⟩

Article dans une revue inserm-02144074v1

A rapid, simple and sensitive liquid chromatography tandem mass spectrometry assay to determine amoxicillin concentrations in biological matrix of little volume

Sebastian Franck , Tania Fuhrmann-Selter , Jan Joseph , Robin Michelet , Fiordiligie Casilag et al.

Talanta, 2019, 201, pp.253-258. ⟨10.1016/j.talanta.2019.03.098⟩

Article dans une revue istex inserm-02144087v1

Therapeutic Synergy Between Antibiotics and Pulmonary Toll-Like Receptor 5 Stimulation in Antibiotic-Sensitive or -Resistant Pneumonia

Laura Matarazzo , Fiordiligie Casilag , Rémi Porte , Frederic Wallet , Delphine Cayet et al.

Frontiers in Immunology, 2019, 10, pp.723. ⟨10.3389/fimmu.2019.00723⟩

Article dans une revue inserm-02144080v1

Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01

Laurye van Maele , Delphine Fougeron , Delphine Cayet , Aurélie Chalon , Diego Piccioli et al.

European Journal of Immunology, 2019, 49 (12), pp.2134-2145. ⟨10.1002/eji.201948234⟩

Article dans une revue inserm-02398403v1

Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation

Fabien Bastaert , Saadé Kheir , Vinciane Saint-Criq , Bérengère Villeret , Pham My-Chan Dang et al.

Frontiers in Immunology, 2018, 9, pp.1675. ⟨10.3389/fimmu.2018.01675⟩

Article dans une revue inserm-02078851v1

Alteration of Flt3-Ligand-dependent de novo generation of conventional dendritic cells during influenza infection contributes to respiratory bacterial superinfection

Ranin Beshara , Valentin Sencio , Daphnée Soulard , Adeline Barthélémy , Josette Fontaine et al.

PLoS Pathogens, 2018, 14 (10), pp.e1007360. ⟨10.1371/journal.ppat.1007360⟩

Article dans une revue inserm-02078841v1

Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae

Khalil Farhat , Gwennaëlle Bodart , Chantal Charlet-Renard , Christophe Desmet , Michel Moutschen et al.

Frontiers in Immunology, 2018, 9, pp.2175. ⟨10.3389/fimmu.2018.02175⟩

Article dans une revue inserm-02078849v1

Compartmentalized Antimicrobial Defenses in Response to Flagellin

Aneesh Vijayan , Martin Rumbo , Christophe Carnoy , Jean-Claude Sirard

Trends in Microbiology, 2017, 9, pp.143 - 153. ⟨10.1016/j.tim.2017.10.008⟩

Article dans une revue inserm-01671191v1

Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.

Catherine Sabatel , Coraline Radermecker , Laurence Fievez , Genevieve Paulissen , Svetoslav Chakarov et al.

Immunity, 2017, 46 (3), pp.457-473. ⟨10.1016/j.immuni.2017.02.016⟩

Article dans une revue inserm-01529380v1

Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Rémi Porte , Laurye van Maele , Natalia Muñoz-Wolf , Benoit Foligné , Laure Dumoutier et al.

Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩

Article dans une revue inserm-01529315v1

Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model.

Carolina Iraporda , David E Romanin , Ana A Bengoa , Agustina J Errea , Delphine Cayet et al.

Frontiers in Immunology, 2016, 7, pp.651. ⟨10.3389/fimmu.2016.00651⟩

Article dans une revue inserm-01529366v1

Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion.

Natalia Muñoz-Wolf , Analía Rial , Delphine Fougeron , Julien Tabareau , Jean-Claude Sirard et al.

Future Microbiology, 2016, 11 (9), pp.1167-77. ⟨10.2217/fmb-2016-0045⟩

Article dans une revue inserm-01529275v1

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner.

Agustina Errea , Delphine Cayet , Philippe Marchetti , Cong Tang , Jerome Kluza et al.

PLoS ONE, 2016, 11 (11), pp.e0163694. ⟨10.1371/journal.pone.0163694⟩

Article dans une revue inserm-01529298v1

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Magdalena Matusiak , Nina van Opdenbosch , Lieselotte Vande Walle , Jean-Claude Sirard , Thirumala-Devi Kanneganti et al.

Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (5), pp.1541-1546. ⟨10.1073/pnas.1417945112⟩

Article dans une revue inserm-01182904v1

Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4+ T cells.

Agathe Goubard , Caroline Loïez , Jun Abe , Caroline Fichel , Stéphanie Herwegh et al.

Infection and Immunity, 2015, 83 (5), pp.2053-64. ⟨10.1128/IAI.02339-14⟩

Article dans une revue inserm-01182906v1

A toll-like receptor 5 agonist improves the efficacy of antibiotics in the treatment of primary and influenza-associated pneumococcal mouse infections.

Rémi Porte , Delphine Fougeron , Natalia Muñoz-Wolf , Julien Tabareau , Anne-France Georgel et al.

Antimicrobial Agents and Chemotherapy, 2015, 59 (10), pp.6064-6072. ⟨10.1128/AAC.01210-15⟩

Article dans une revue inserm-01182908v1

Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract

Delphine Fougeron , Laurye van Maele , Pascal Songhet , Delphine Cayet , David Hot et al.

Vaccine, 2015, 33 (29), pp.3331-41. ⟨10.1016/j.vaccine.2015.05.022⟩

Article dans une revue inserm-01182907v1

In vivo germination of Bacillus anthracis spores during murine cutaneous infection.

Jean-Philippe Corre , Alejandro Piris-Gimenez , Marie Moya-Nilges , Gregory Jouvion , Agnes Fouet et al.

Journal of Infectious Diseases, 2013, 207 (3), pp.450-7. ⟨10.1093/infdis/jis686⟩

Article dans une revue inserm-00926617v1

Airway structural cells regulate TLR5-mediated mucosal adjuvant activity.

Laurye van Maele , Delphine Fougeron , Laure Janot , Arnaud Didierlaurent , Delphine Cayet et al.

Mucosal Immunology, 2013, epub ahead of print. ⟨10.1038/mi.2013.66⟩

Article dans une revue inserm-00925663v1

Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection.

Stoyan Ivanov , Joelle Renneson , Josette Fontaine , Adeline Barthelemy , Christophe Paget et al.

Journal of Virology, 2013, 87 (12), pp.6911-24. ⟨10.1128/JVI.02943-12⟩

Article dans une revue inserm-00926618v1

The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.

Maria L. Knudsen , Daniel X. Johansson , Linda Kostic , Eva K. L. Nordström , Karin Tegerstedt et al.

PLoS ONE, 2013, 8 (6), pp.e65964. ⟨10.1371/journal.pone.0065964⟩

Article dans une revue inserm-00925649v1

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.

Boas Felmy , Pascal Songhet , Emma Marie Caroline Slack , Andreas J. Müller , Marcus Kremer et al.

PLoS ONE, 2013, 8 (10), pp.e77204. ⟨10.1371/journal.pone.0077204⟩

Article dans une revue inserm-00925654v1

Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection.

Griselda Moreno , Agustina Errea , Laurye van Maele , Roy Roberts , Hélène Léger et al.

Microbes and Infection, 2013, 15 (10-11), pp.708-18. ⟨10.1016/j.micinf.2013.06.010⟩

Article dans une revue inserm-00925669v1

Transgenic mouse model harboring the transcriptional fusion ccl20-luciferase as a novel reporter of pro-inflammatory response.

Martina Crispo , Laurye van Maele , Julien Tabareau , Delphine Cayet , Agustina Errea et al.

PLoS ONE, 2013, 8 (11), pp.e78447. ⟨10.1371/journal.pone.0078447⟩

Article dans une revue inserm-00925644v1

Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-γ-mediated immunity.

Juan M. Marqués , Analía Rial , Natalia Muñoz , Francois-Xavier Pellay , Laurye van Maele et al.

Immunobiology, 2012, 217 (4), pp.420-9. ⟨10.1016/j.imbio.2011.10.012⟩

Article dans une revue istex inserm-00926614v1

Key role for respiratory CD103(+) dendritic cells, IFN-γ, and IL-17 in protection against Streptococcus pneumoniae infection in response to α-galactosylceramide.

Stoyan Ivanov , Josette Fontaine , Christophe Paget , Elodie Macho Fernandez , Laurye van Maele et al.

Journal of Infectious Diseases, 2012, 206 (5), pp.723-34. ⟨10.1093/infdis/jis413⟩

Article dans une revue inserm-00926616v1

IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.

Laure Dumoutier , Magali de Heusch , Ciriana Orabona , Naoko Satoh-Takayama , Gerard Eberl et al.

European Journal of Immunology, 2011, 41 (4), pp.1075-85. ⟨10.1002/eji.201040878⟩

Article dans une revue inserm-00926611v1

The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal salmonella diarrhea.

Kathrin Endt , Bärbel Stecher , Samuel Chaffron , Emma Slack , Nicolas Tchitchek et al.

PLoS Pathogens, 2010, 6 (9), pp.e1001097. ⟨10.1371/journal.ppat.1001097⟩

Article dans une revue inserm-00520162v1

The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells

Céline Beauvillain , Francesca Meloni , Jean-Claude Sirard , Simon Blanchard , Ulrich Jarry et al.

Journal of Hepatology, 2010, 52 (5), pp.644-51. ⟨10.1016/j.jhep.2009.11.031⟩

Article dans une revue inserm-00926610v1

TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.

Laurye van Maele , Christophe Carnoy , Delphine Cayet , Pascal Songhet , Laure Dumoutier et al.

Journal of Immunology, 2010, 185 (2), pp.1177-85. ⟨10.4049/jimmunol.1000115⟩

Article dans une revue inserm-00495564v1

Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection.

Natalia Munoz , Laurye van Maele , Juan Marqués , Analia Rial , Jean-Claude Sirard et al.

Infection and Immunity, 2010, 78 (10), pp.4226-4233. ⟨10.1128/IAI.00224-10⟩

Article dans une revue inserm-00520159v1

IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium.

Pascal Songhet , Manja Barthel , Till A Röhn , Laurye van Maele , Delphine Cayet et al.

PLoS ONE, 2010, 5 (11), pp.e13804. ⟨10.1371/journal.pone.0013804⟩

Article dans une revue inserm-00926613v1

Toll-like receptor 5- and lymphotoxin beta receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics.

Jean-Claude Sirard , Arnaud Didierlaurent , Delphine Cayet , Frédéric Sierro , Martin Rumbo

Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1789 (5), pp.386-94. ⟨10.1016/j.bbagrm.2009.03.001⟩

Article dans une revue inserm-00385296v1

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.

Laure Janot , Jean-Claude Sirard , Thomas Secher , Nicolas Noulin , Lizette Fick et al.

European Journal of Immunology, 2009, 39 (6), pp.1587-96. ⟨10.1002/eji.200838907⟩

Article dans une revue inserm-00385299v1

Deletion of flagellin's hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity.

Clément Nempont , Delphine Cayet , Martin Rumbo , Coralie Bompard , Vincent Villeret et al.

Journal of Immunology, 2008, 181 (3), pp.2036-2043. ⟨10.4049/jimmunol.181.3.2036⟩

Article dans une revue inserm-00309796v1

Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

Arnaud Didierlaurent , John Goulding , Seema Patel , Robert Snelgrove , Lionel Low et al.

Journal of Experimental Medicine, 2008, 205 (2), pp.323-9. ⟨10.1084/jem.20070891⟩

Article dans une revue inserm-00227540v1

Adhesin-dependent binding and uptake of Salmonella enterica serovar Typhimurium by dendritic cells.

Aizhen Guo , Melissa A. Lasaro , Jean-Claude Sirard , Jean-Pierre Kraehenbuhl , Dieter M. Schifferli

Microbiology, 2007, 153 (Pt 4), pp.1059-69. ⟨10.1099/mic.0.2006/000331-0⟩

Article dans une revue inserm-00177727v1

Nod-like receptors: cytosolic watchdogs for immunity against pathogens.

Jean-Claude Sirard , Cécile Vignal , Rodrigue Dessein , Mathias Chamaillard

PLoS Pathogens, 2007, 3 (12), pp.e152. ⟨10.1371/journal.ppat.0030152⟩

Article dans une revue inserm-00223906v1

A key role of dendritic cells in probiotic functionality.

Benoit Foligne , Georgia Zoumpopoulou , Joelle Dewulf , Amena Ben Younes , Fabrice Chareyre et al.

PLoS ONE, 2007, 2 (3), pp.e313. ⟨10.1371/journal.pone.0000313⟩

Article dans une revue inserm-00177781v1

Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.

Rachel A. Luu , Komal Gurnani , Renu Dudani , Rajagopal Kammara , Henk van Faassen et al.

Journal of Immunology, 2006, 177 (3), pp.1516-1525. ⟨10.4049/jimmunol.177.3.1516⟩

Article dans une revue inserm-00177783v1

Pathogen-specific TLR signaling in mucosa: mutual contribution of microbial TLR agonists and virulence factors.

Jean-Claude Sirard , Mariela Bayardo , Arnaud Didierlaurent

European Journal of Immunology, 2006, 36, pp.260-3. ⟨10.1002/eji.200535777⟩

Article dans une revue inserm-00000042v1

Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.

Arnaud Didierlaurent , Brian Brissoni , Dominique Velin , Natalia Aebi , Aubry Tardivel et al.

Molecular and Cellular Biology, 2006, 26, pp.735-42. ⟨10.1128/MCB.26.3.735-742.2006⟩

Article dans une revue inserm-00000043v1

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