
Jean-Jacques LAREYRE
Présentation
My research aim to better understand molecular mechanisms underlying the sexual maturation (puberty) in fish, particularly in male. The initiation of the male gametogenesis (spermatogenesis) is an important biological process that impacts puberty onset and ultimately fish fertility. Puberty onset depends on the activation of the gonadotrope axis (GnRHs) that ultimately control the release from the pituitary of two gonadotropins named FSH and LH. Both hormones control the two main testicular functions (spermatogeneis and steroidogenesis). Spermatogeneis relies on the balance between renewal and proliferation/differentiation of germ stem cells. The role of the sexual hormones (gonadotropins and gonadotropin induced sexual steroids) in the regulation of this balance remains poorly understood.
My basic research aims to :
- characterize the molecular profile of adult germ stem cells in teleost fish species
- characterize gonadal factors that may be involved in the regulation of germ stem cell fate (germ stem cell renewal or germline differentiation)
- understanding the molecular mechanisms underlying the distinct effects of the sexual hormones (steroids and gonadotropins)
My applied research aims to :
- improve the practicability of germ stem cell grafting
- develop early markers of precocious puberty
Publications
Publications
Fish reproductionElsevier, pp.351-558, 2010
Ouvrages
hal-00453737
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Testicular function and hormonal regulation in fishesDavid O. Norris; Kristin H. Lopez. Hormones and Reproduction of Vertebrates, 1. Fishes, Academic Press, pp.63 - 90, 2024, 978-0-443-16009-7. ⟨10.1016/b978-0-443-16009-7.00009-8⟩
Chapitre d'ouvrage
hal-04680023
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La reproduction des poissonsLa reproduction animale et humaine, Editions Quae, 751 p., 2014, Collection Synthèses, 978-2-7592-2208-7
Chapitre d'ouvrage
hal-01205108
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Sexualité et reproductionLa truite arc-en-ciel. De la biologie à l'élevage, Editions Quae, 2010, Synthèses, 978-2-7592-0875-3
Chapitre d'ouvrage
hal-01193565
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Recent advances in fish sex determination and gametogenesis studies through genomic investigationsRecent advances in fish reproductive biology, Research Signpost, 2010, 978-81-308-0397-5
Chapitre d'ouvrage
hal-01205038
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Retinoids and epididymal functionThe epididymis: from molecules to clinical practice, Kluwer Academic Publishers, 2002, 0-306-46684-8
Chapitre d'ouvrage
hal-02832184
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Gene expression and epididymal functionThe epididymis: from molecules to clinical practice, Kluwer Academic Publishers, 2002, 0-306-46684-8
Chapitre d'ouvrage
hal-02832185
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Composition of the rainbow trout testicular extracellular matrix and progress towards the development of testicular organoids12. International Symposium on Reproductive Physiology of Fish, May 2023, Heraklion, Greece.
Poster de conférence
hal-04102161
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Composition of the Rainbow trout testicular extracellular matrix using diaPASEFProteoAix 2023, Jun 2023, Aix-en-Provence, France
Poster de conférence
hal-04158632
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La greffe des cellules souches germinales permet la production de populations monosexes chez les salmonidésSéminaire Défis Scientifiques du Département Physiologie Animale et Systèmes d'Elevage, Nov 2019, Rennes, France. 85 p., 2019, Recueil des résumés
Poster de conférence
hal-02738327
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Développement d’une procédure de production de populations monosexes femelles chez les salmonidés sans utilisation d’hormone exogène6. Journées de la Recherche Filière Piscicole, Jul 2019, Paris, France. , 2019
Poster de conférence
hal-02184267
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Régénération de lignées de truite par transplantation de cellules souches germinales6. Journées de la Recherche Filière Piscicole, Jul 2019, Paris, France. , 2019
Poster de conférence
hal-02737370
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Towards improving the practicability of germ stem cell grafting in commercial salmonids farms7. International Workshop on the Biology of Fish Gametes, Sep 2019, Rennes, France. , pp.119-120, 2019
Poster de conférence
hal-02282235
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Gene expression profiling during rainbow trout ontogenesis reveals successive changes gated in teleosts in germ stem cell molecular signature and regulatory pathways11. International Symposium on Reproductive Physiology of Fish, Jun 2018, Manaus, Brazil. , 251 p., 2018, New frontiers in reproductive diversity in a changing environment
Poster de conférence
hal-01812833
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Mise en évidence d'étapes de transition successives des cellules souches germinales qui conduisent à l'apparition de progéniteurs au cours de l’ontogénèse de la truite arc-en-ciel (Oncorhynchus mykiss)Journées d'Animation Scientifique du département Phase (JAS Phase 2018), Apr 2018, Rennes, France. 2018, Journées d’animation scientifiques du département Phase - Recueil des résumés
Poster de conférence
hal-01771814
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Germ stem cell transplantation procedure for the regeneration of isogenic trout lines11. International Symposium on Reproductive Physiology of Fish, Jun 2018, Manaus, Brazil. , 251 p., 2018, New frontiers in reproductive diversity in a changing environment
Poster de conférence
hal-01812825
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The in vivo targeted mutation of the mineralocorticoid and glucocorticoid receptors in zebrafish (Danio rerio) provides evidence that both receptors have distinct and redundant effects on female reproductionESAC Symposium 2018, Dec 2018, Erlangen, Germany
Poster de conférence
hal-03911965
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Isolement et caractérisation de cellules germinales souches adultes à partir de lignées de poissons zèbre transgéniquesJournées d’Animation des Crédits Incitatifs du Département de Physiologie Animale et Systèmes d’Elevage (JACI Phase 2016), Apr 2016, Tours, France. , 115 p., 2016, Crédits incitatifs financés entre 2011 et 2014
Poster de conférence
hal-02740984
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Stemness properties and molecular signature of paired spermatogonia in adult zebrafishGermline Stem Cells Conference, Jun 2016, San Francisco, CA, United States. , 2016, Abcam Germline Stem Cells Conference
Poster de conférence
hal-02743872
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Stemness properties and molecular signature of paired spermatogonia in adult zebrafish19. European Testis Workshop, Jun 2016, Saint-Malo, France. , 2016, European Workshop on the Molecular and Cellular Endocrinology of the testis
Poster de conférence
hal-02743666
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Isolation and molecular characterization of sertoli and undifferentiated spermatogonial cell populations using GFP-expressing transgenic zebrafish lines1. Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro
Poster de conférence
hal-01897082
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Spermatogonial Stem Cells: the Gdnf-Gfra1 pathway regulation is spermatogenetic dependent in trout, and differs from that in mouse1. Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro
Poster de conférence
hal-02740720
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High-resolution 3D imaging of whole zebrafish ovary9. European Zebrafish Meeting, Jun 2015, Oslo, Norway. , 2015, Zebrafish 2015
Poster de conférence
hal-02742931
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Gdnf-Gfra1 pathway is expressed in a spermatogenetic dependent manner and is regulated by Fsh in a fish testis27. Conference of European Comparative Endocrinologists, Aug 2014, Rennes, France. 2014, CECE 2014
Poster de conférence
hal-02743826
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Hypothalamic and pituitary factors controlling reproduction in atlantic salmon10. International Symposium on Reproductive Physiology of Fish, May 2014, Olhão, Portugal. 2014, 10th ISRPF
Poster de conférence
hal-02743755
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FSH and LH have shared and separate effects on gene expression in fish testis7. International Symposium on Fish Endocrinology, Sep 2012, Buenos Aires, Argentina. , 2012, Program and abstracts book. 7 ISFE Buenos Aires 2012
Poster de conférence
hal-02747127
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Conserved molecular markers of spermatogonial stem cells in the rainbow trout testis17. European Testis Workshop, Apr 2012, Djurönäset, Sweden. 153 p., 2012
Poster de conférence
hal-02747119
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Investigation on two putative androgen-responsive genes expressed in the gonads of teleostean fish species7. International Symposium on Fish Endocrinology, Sep 2012, Buenos Aires, Argentina. , 2012, Program and abstracts book. 7 ISFE Buenos Aires 2012
Poster de conférence
hal-02745611
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Hypothalamic and pituitary factors controlling reproduction in Atlantic salmon1. International Conference on Integrative Salmonid Biology ICISB, Jun 2012, Oslo, Norway. 2012, ICISB 2012
Poster de conférence
hal-02746659
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c-myc: evolutionary history in teleosts and duplicated c-myca genes characterization in goldfish4. Journées d'Animation Scientifique du département Phase (JAS Phase 2012), Jan 2012, Rennes, France. 2012
Poster de conférence
hal-02806162
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The cell context influences rainbow trout gonadotropin receptors selectivity9. International Symposium on Reproductive Physiology of Fish, Aug 2011, Thrissur (Cochin), India. Indian Society for Education and Environment, Indian Journal of Science and Technology, 4 (S8), 2011, Proceedings of 9th International Symposium on Reproductive Physiology of fish
Poster de conférence
hal-02746662
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Expression and promoter methylation pattern of three major developmental genes, sox2, nanog, and c-myc, during early embryo development in goldfish44. Annual Meeting of the Society for the Study of Reproduction (SSR), Jul 2011, Portland, Oregon, United States. Society for the Study of Reproduction, Biology of Reproduction, 85, 2011, Reproduction and the World's Future
Poster de conférence
hal-02746166
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Emergence of estrogen signalling in the brain of zebrafish embryos and larvae8. International Symposium on Reproductive Physiology of Fish, Jun 2007, Saint-Malo, France. , 2007, 8th international Symposium on Reproductive Physiology of Fish
Poster de conférence
hal-02756319
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Rainbow trout anti-Müllerian hormone gene <em>(amh)</em> structure and expression8. International Symposium on Reproductive Physiology of Fish, Jun 2007, Saint-Malo, France. MNHN Museum National d'Histoire Naturelle, Cybium, 32 (S2), 2008, Comptes-rendus / Proceedings "8th International Symposium on Reproductive Physiology of Fish (ISRPF)
Poster de conférence
hal-02754132
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Comparative distribution of three estrogen receptors in the brain-pituitary complex of the rainbow trout8. International Symposium on Reproductive Physiology of Fish, Jun 2007, Saint-Malo, France. MNHN Museum National d'Histoire Naturelle, Cybium, 32 (S2), 2008, Comptes-Rendus / Proceedings “8th International Symposium on Reproductive Physiology of Fish (ISRPF)”
Poster de conférence
hal-02752946
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Two new TGF beta members are restricted to the gonad and differentially expressed during sex differentiation and gametogenesis in trout8. International Symposium on Reproductive Physiology of Fish, Jun 2007, Saint-Malo, France. MNHN Museum National d'Histoire Naturelle, Cybium, 32 (S2), 2008, Comptes-Rendus / Proceedings “8th International Symposium on Reproductive Physiology of Fish (ISRPF)”
Poster de conférence
hal-02756495
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Expression of a GPR54-like but no agonistic effect of mammalian kisspeptins in trout8. International Symposium on Reproductive Physiology of Fish, Jun 2007, Saint-Malo, France. MNHN Museum National d'Histoire Naturelle, Cybium, 32 (S2), 2008, Comptes rendus / Proceedings "8th International Symposium on Reproductive Physiology of Fish (ISRPF)"
Poster de conférence
hal-02756309
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Rainbow trout FSHR gene structure shows more complexity than the salmon orthologous gene and is differently expressed throughout gametogenesis7. International Symposium on Reproductive Physiology of Fish, May 2003, Mie, Japan. 2003, 7th International Symposium on Reproductive Physiology of Fish. Program and abstracts
Poster de conférence
hal-02763605
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Evidence for two distinct GnRH receptors isoforms expressed in teleosts7. International Symposium on Reproductive Physiology of Fish, May 2003, Mie, Japan. 2003, 7th International Symposium on Reproductive Physiology of Fish. Program and abstracts
Poster de conférence
hal-02763681
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A type II iodothyronine deiodinase, is preferentially expressed in rainbow trout gonads with variations throughout spermatogenesis4. International Symposium on Fish Endocrinology, Jul 2000, Seattle, United States. 2000, 4th International Symposium on Fish Endocrinology
Poster de conférence
hal-02770479
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Mémoire présenté en vue de l'obtention de l'habilitation à diriger des recherches : Etudes de mécanismes moléculaires impliqués dans la production et la maturation des spermatozoïdes chez les vertébrésSciences du Vivant [q-bio]. Université de Rennes 1, 2001
HDR
tel-02831813
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