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Jean-Michel Escoffre

Inserm Senior Researcher
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Jean-Michel Escoffre earned his M.Sc. degrees in Vectorology, Gene Therapy, Vaccinology and in Structure/Function in Macromolecules and Living Processes in 2005 and 2006 respectively, at the University Paul Sabatier (Toulouse, France). He obtained his Ph.D. degrees in Cell Biophysics in 2010 at the Institute of Pharmacology and Structural Biology (IPBS/CNRS, UMR 5089) and University Paul Sabatier. During his PhD fellowship, he investigated the molecular & cellular mechanisms of gene electrotransfer. For his first post-doctoral fellowship, he joined the Institute of Imaging and Brain of the French Institute for Health and Medical Science (Inserm, UMR 930) in Tours, France (2010-2013). He worked in the fields of gene and drug delivery using microbubble-assisted ultrasound. Then, he joined the Imaging Division at UMC Utrecht, The Netherlands. His main research interest was the development of HIFU-mediated anticancer immunotherapy (2013-2015). He is currently pursuing his research as Inserm Senior Researcher at the Institute of Imaging and Brain of the French Institute for Health and Medical Science (Inserm, University of Tours) in Tours, France. His main research interest lie in the fields of biodrug delivery using ultrasound-guided therapeutic ultrasound.


Ultrasound imaging ultrasound sonoporation drug delivery ultrasound neuromodulation


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Delivery of Anticancer Drugs Using Microbubble-Assisted Ultrasound in a 3D Spheroid Model

Marie Roy , Corentin Alix , Julien Burlaud-Gaillard , Damien Fouan , William Raoul
Molecular Pharmaceutics, 2024, Online ahead of print. ⟨10.1021/acs.molpharmaceut.3c00921⟩
Journal articles inserm-04374054v1
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Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review

Marie Roy , Corentin Alix , Ayache Bouakaz , Sophie Serrière , Jean-Michel Escoffre
Pharmaceutics, 2023, 15 (3), pp.806. ⟨10.3390/pharmaceutics15030806⟩
Journal articles inserm-04032858v1
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Sonoporation of the Round Window Membrane on a Sheep Model: A Safety Study

Sandrine Kerneis , Jean-Michel Escoffre , John J Galvin , Ayache Bouakaz , Antoine Presset
Pharmaceutics, 2023, 15 (2), pp.442. ⟨10.3390/pharmaceutics15020442⟩
Journal articles inserm-03964324v1
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Ultrasound Neurostimulation in Mice: Impact of Ultrasound Settings and Beam Properties

Jean-Michel Escoffre , Ayache Bouakaz , Tarik Iazourène , Hanaa Malloul , Edward Oujagir
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2022, Ahead of print
Journal articles inserm-03528841v1
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Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: From preclinical to clinical studies

Jean-Michel Escoffre , Najib Sekkat , Edward Oujagir , Sylvie Bodard , Coralie Mousset
Expert Opinion on Drug Delivery, 2022, Online ahead of print. ⟨10.1080/17425247.2022.2061459⟩
Journal articles inserm-03626073v1
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Microbubble-assisted ultrasound for imaging and therapy of melanoma skin cancer: A systematic review

François Avry , Coralie Mousset , Edward Oujagir , Ayache Bouakaz , Valérie Gouilleux-Gruart
Ultrasound in Medicine & Biology, inPress, 48 (11), pp.2174-2198. ⟨10.1016/j.ultrasmedbio.2022.06.021⟩
Journal articles inserm-03707096v1
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Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?

Hugo Alarcan , Yara Al Ojaimi , Debora Lanznaster , Jean-Michel Escoffre , Philippe Corcia
Journal of Personalized Medicine, 2022, 12, pp.1071. ⟨10.3390/jpm12071071⟩
Journal articles inserm-03723283v1
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First Metabolomic Signature of Blood-Brain Barrier Opening Induced by Microbubble-Assisted Ultrasound

Antoine Presset , Sylvie Bodard , Antoine Lefèvre , Anaïs Millet , Edward Oujagir
Frontiers in Molecular Neuroscience, 2022, 15, pp.888318. ⟨10.3389/fnmol.2022.888318⟩
Journal articles inserm-03707049v1
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Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

Suzanne Dufresne , Cindy Richard , Arthur Dieumegard , Luz Orfila , Gregory Delpon
Cancers, 2021, 13 (21), pp.5402. ⟨10.3390/cancers13215402⟩
Journal articles inserm-03409985v1
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Acoustic and Elastic Properties of a Blood Clot during Microbubble-Enhanced Sonothrombolysis: Hardening of the Clot with Inertial Cavitation

Laurent Auboire , Damien Fouan , Jean-Marc Grégoire , Fréderic Ossant , Camille Plag
Pharmaceutics, 2021, 13, pp.1566. ⟨10.3390/pharmaceutics13101566⟩
Journal articles inserm-03354808v1
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Editorial: Bubbles, Droplets and Micelles for Acoustically-Mediated Drug/Gene Delivery

Jean-Michel Escoffre , Baudouin Denis de Senneville , Noboru Sasaki , Marc Derieppe
Frontiers in Pharmacology, 2020, 11, pp.954. ⟨10.3389/fphar.2020.00954⟩
Journal articles inserm-02915877v1
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Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model

Fabien Espitalier , François Darrouzain , Jean-Michel Escoffre , David Ternant , Eric Piver
Frontiers in Pharmacology, 2020, 10, pp.1562. ⟨10.3389/fphar.2019.01562⟩
Journal articles inserm-02441635v1
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New insights on the role of ROS in the mechanisms of sonoporation-mediated gene delivery

Jean-Michel Escoffre , Pablo Campomanes , Mounir Tarek , Ayache Bouakaz
Ultrasonics Sonochemistry, 2020, 64, pp.104998. ⟨10.1016/j.ultsonch.2020.104998⟩
Journal articles inserm-02488866v1
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Endothelial Cells, First Target of Drug Delivery Using Microbubble-Assisted Ultrasound

Antoine Presset , Corentin Bonneau , Sasaoka Kazuyoshi , Lydie Nadal-Desbarats , Takigucho Mitsuyoshi
Ultrasound in Medicine & Biology, 2020, Online ahead of print. ⟨10.1016/j.ultrasmedbio.2020.03.013⟩
Journal articles inserm-02565367v1
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Ultrasound-responsive cavitation nuclei for therapy and drug delivery

Klazina Kooiman , Silke Roovers , Simone a G Langeveld , Robert T Kleven , Heleen Dewitte
Ultrasound in Medicine & Biology, In press
Journal articles inserm-02437994v1
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A systematic review of ultrasound imaging and therapy in mental disorders

Marta Andrea Siragusa , Jean-Pierre Remenieras , Ayache Bouakaz , Jean-Michel Escoffre , Frédéric Patat
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 101, pp.109919. ⟨10.1016/j.pnpbp.2020.109919⟩
Journal articles inserm-02519433v1

Comment on “The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis using an In Vitro Circulating Flow Model”

Laurent Auboire , Jean-Michel Escoffre
Journal of Stroke and Cerebrovascular Diseases, 2019, 28 (7), pp.2052. ⟨10.1016/j.jstrokecerebrovasdis.2019.03.039⟩
Journal articles inserm-02438124v1
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Minireview: Biophysical Mechanisms of Cell Membrane Sonopermeabilization. Knowns and Unknowns

Jean-Michel Escoffre , Ayache Bouakaz
Langmuir, 2019, 35 (31), pp.10151-10165. ⟨10.1021/acs.langmuir.8b03538⟩
Journal articles inserm-02438144v1
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Quantitative Ultrasound in Ex Vivo Fibrotic Rabbit Livers

Emilie Franceschini , Jean-Michel Escoffre , Anthony Novell , Laurent Auboire , Vanda Mendes
Ultrasound in Medicine & Biology, 2019, 45 (7), pp.1777-1786. ⟨10.1016/j.ultrasmedbio.2019.02.013⟩
Journal articles hal-02200101v1
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Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model

Diane Bressand , Anthony Novell , Alban Girault , William Raoul , Gaëlle Fromont-Hankard
Molecular Pharmaceutics, 2019, 16 (9), pp.3814-3822. ⟨10.1021/acs.molpharmaceut.9b00416⟩
Journal articles hal-02301225v1
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Experience implication in subjective surgical ergonomics comparison between laparoscopic and robot-assisted surgeries

V. Mendes , Franck Bruyère , Jean-Michel Escoffre , Aurélien Binet , Hubert Lardy
Journal of Robotic Surgery, 2019, ⟨10.1007/s11701-019-00933-2⟩
Journal articles inserm-02438134v1
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Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-mediated Release from Thermosensitive Liposomes

Marc Derieppe , Jean-Michel Escoffre , Baudouin Denis de Senneville , Quincy van Houtum , Angelique Barten-van Rijbroek
Contrast Media and Molecular Imaging, 2019, ⟨10.1155/2019/2645928⟩
Journal articles hal-02377672v1

Experimental Implementation of a Pulse Compression Technique Using Coherent Plane-Wave Compounding

Yanis Mehdi Benane , Denis Bujoreanu , Roberto J Lavarello , F. Varray , Jean-Michel Escoffre
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2018, 65 (6), pp.1025 - 1036. ⟨10.1109/TUFFC.2018.2820747⟩
Journal articles hal-01957676v1
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Development of a Fluid Dynamic Model for Quantitative Contrast-Enhanced Ultrasound Imaging

Baudouin Denis de Senneville , Anthony Novell , Chloé J. Arthuis , Vanda Mendes , Paul-Armand Dujardin
IEEE Transactions on Medical Imaging, 2018, 37 (2), pp.372-383
Journal articles hal-01962485v1
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Microbubbles combined with ultrasound therapy in ischemic stroke: A systematic review of in-vivo preclinical studies

Laurent Auboire , Charles Sennoga , Jean-Marc Hyvelin , Frédéric Ossant , Jean-Michel Escoffre
PLoS ONE, 2018, 13 (2), pp.e0191788. ⟨10.1371/journal.pone.0191788⟩
Journal articles hal-01761337v1
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Real-Time Monitoring of Placental Oxygenation during Maternal Hypoxia and Hyperoxygenation Using Photoacoustic Imaging

Chloé J. Arthuis , Anthony Novell , Florian Raes , Jean-Michel Escoffre , Stéphanie Lerondel
PLoS ONE, 2017, 12 (1), pp.e0169850. ⟨10.1371/journal.pone.0169850⟩
Journal articles inserm-02438173v1
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Microbubble-Assisted Ultrasound-Induced Transient Phosphatidylserine Translocation

Jean-Michel Escoffre , Marc Derieppe , Bart Lammertink , Clemens Bos , Chrit Moonen
Ultrasound in Medicine & Biology, 2017, 43 (4), pp.838-851. ⟨10.1016/j.ultrasmedbio.2016.12.002⟩
Journal articles inserm-02438167v1
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Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis

Laurent Auboire , Jean-Michel Escoffre , Damien Fouan , Jean-René Jacquet , Frédéric Ossant
Scientific Reports, 2017, 7 (1), pp.6211. ⟨10.1038/s41598-017-06089-z⟩
Journal articles inserm-02438161v1

Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring

Charles Sennoga , Emma Kanbar , Laurent Auboire , Paul-Armand Dujardin , Damien Fouan
Expert Opinion on Drug Delivery, 2016, 14 (9), pp.1031-1043. ⟨10.1080/17425247.2017.1266328⟩
Journal articles inserm-02438187v1

Mild hyperthermia influence on Herceptin® properties

Jean-Michel Escoffre , Roel Deckers , Noboru Sasaki , Clemens Bos , Chrit Moonen
Journal of Radiology and Oncology, 2015, 49 (1), pp.41-49. ⟨10.2478/raon-2014-0045⟩
Journal articles inserm-02438251v1

Focused ultrasound influence on calcein-loaded thermosensitive stealth liposomes

Anthony Novell , Chantal Al Sabbagh , Jean-Michel Escoffre , Cedric Gaillard , Nicolas Tsapis
International Journal of Hyperthermia, 2015, 31 (4), pp.349-358. ⟨10.3109/02656736.2014.1000393⟩
Journal articles inserm-02438261v1

Recruitment of endocytosis in sonopermeabilization-mediated drug delivery: a real-time study

Marc Derieppe , Katarzyna Rojek , Jean-Michel Escoffre , Baudouin Denis de Senneville , Chrit Moonen
Physical Biology, 2015, 12 (4), pp.046010. ⟨10.1088/1478-3975/12/4/046010⟩
Journal articles inserm-02438247v1
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Development of a tumor tissue-mimicking model with endothelial cell layer and collagen gel for evaluating drug penetration

Noboru Sasaki , Clemens Bos , Jean-Michel Escoffre , Gert Storm , Chrit Moonen
International Journal of Pharmaceutics, 2015, 482 (1-2), pp.118-122. ⟨10.1016/j.ijpharm.2015.01.039⟩
Journal articles inserm-02438274v1
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Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil

Chantal Al Sabbagh , Nicolas Tsapis , Anthony Novell , Patricia Calleja-Gonzalez , Jean-Michel Escoffre
Pharmaceutical Research, 2015, 32 (5), pp.1585-1603. ⟨10.1007/s11095-014-1559-0⟩
Journal articles inserm-02438401v1
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Recruitment of endocytosis in sonopermeabilization-mediated drug delivery: A real-time study

Marc Derieppe , Katarzyna Rojek , Jean-Michel Escoffre , Baudouin Denis de Senneville , Chrit T. W. Moonen
Physical Biology, 2015
Journal articles hal-01159814v1
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Sonochemotherapy: from bench to bedside

Bart Lammertink , Clemens Bos , Roel Deckers , Gert Storm , Chrit Moonen
Frontiers in Pharmacology, 2015, 6, ⟨10.3389/fphar.2015.00138⟩
Journal articles inserm-02438239v1
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Role of endocytosis in sonoporation-mediated membrane permeabilization and uptake of small molecules: a electron microscopy study

A Zeghimi , Jean-Michel Escoffre , Ayache Bouakaz
Physical Biology, 2015, 12 (6), pp.066007. ⟨10.1088/1478-3975/12/6/066007⟩
Journal articles inserm-02438214v1

Serum influence on in-vitro gene delivery using microbubble-assisted ultrasound

Aya Zeghimi , Novell Anthony , Rose-Anne Thepault , Patrick Vourc'H , Ayache Bouakaz
Journal of Drug Targeting, 2014, 22 (8), pp.748-760. ⟨10.3109/1061186X.2014.921922⟩
Journal articles inserm-02438479v1

Membrane disorder and phospholipid scrambling in electropermeabilized and viable cells

Jean-Michel Escoffre , Elisabeth Bellard , Cécile Faurie , Sarah C. Sébaï , Muriel Golzio
Biochimica et Biophysica Acta:Biomembranes, 2014, 1838 (7), pp.1701-1709. ⟨10.1016/j.bbamem.2014.02.013⟩
Journal articles inserm-02438553v1

Evidence for electro-induced membrane defects assessed by lateral mobility measurement of a GPi anchored protein

Jean-Michel Escoffre , Marie Hubert , Justin Teissié , Marie-Pierre Rols , Cyril Favard
European Biophysics Journal, 2014, 43 (6-7), pp.277-286. ⟨10.1007/s00249-014-0961-1⟩
Journal articles inserm-02438517v1

Evaluation of chirp reversal power modulation sequence for contrast agent imaging

Novell Anthony , Charles Sennoga , Jean-Michel Escoffre , Jennifer Chaline , Ayache Bouakaz
Physics in Medicine and Biology, 2014, 59 (17), pp.5101-5117. ⟨10.1088/0031-9155/59/17/5101⟩
Journal articles inserm-02438448v1

New insights into uteroplacental perfusion: Quantitative analysis using Doppler and contrast-enhanced ultrasound imaging

Chloé Julie Arthuis , Novell Anthony , Jean-Michel Escoffre , Frédéric Patat , Ayache Bouakaz
Placenta, 2013, 34 (5), pp.424-431. ⟨10.1016/j.placenta.2013.01.019⟩
Journal articles inserm-02438627v1

Focused ultrasound mediated drug delivery from temperature-sensitive liposomes: in-vitro characterization and validation

Jean-Michel Escoffre , Novell Anthony , Mariska de Smet , Ayache Bouakaz
Physics in Medicine and Biology, 2013, 58 (22), pp.8135-8151. ⟨10.1088/0031-9155/58/22/8135⟩
Journal articles inserm-02438570v1

Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-triggered drug delivery

Jean-Michel Escoffre , Christophoros Mannaris , Bart Geers , Anthony Novell , Ine Lentacker
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2013, 60 (1), pp.78-87. ⟨10.1109/TUFFC.2013.2539⟩
Journal articles inserm-02438665v1

In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects

Jean-Michel Escoffre , Aya Zeghimi , Novell Anthony , Ayache Bouakaz
Current Gene Therapy, 2013, 13 (1), pp.2-14. ⟨10.2174/156652313804806606⟩
Journal articles inserm-02438876v1

Effect of different parameters used for in vitro gene electrotransfer on gene expression efficiency, cell viability and visualization of plasmid DNA at the membrane level

Sasa Haberl , Masa Kanduser , Karel Flisar , Dusa Hodzic , Vladimir Bostjan Bregar
The Journal of Gene Medicine, 2013, 15 (5), pp.169-181. ⟨10.1002/jgm.2706⟩
Journal articles inserm-02438609v1

Second Harmonic and Subharmonic for Non-Linear Wideband Contrast Imaging Using a Capacitive Micromachined Ultrasonic Transducer Array

Novell Anthony , Jean-Michel Escoffre , Ayache Bouakaz
Ultrasound in Medicine & Biology, 2013, 39 (8), pp.1500-1512. ⟨10.1016/j.ultrasmedbio.2013.03.002⟩
Journal articles inserm-02438581v1

Irinotecan Delivery by Microbubble-Assisted Ultrasound: In Vitro Validation and a Pilot Preclinical Study

Jean-Michel Escoffre , Novell Anthony , Sophie Serriere , Thierry Lecomte , Ayache Bouakaz
Molecular Pharmaceutics, 2013, 10 (7), pp.2667-2675. ⟨10.1021/mp400081b⟩
Journal articles inserm-02438593v1

Microbubble attenuation and destruction: are they involved in sonoporation efficiency?

Jean-Michel Escoffre , Novell Anthony , Julien Piron , Aya Zeghimi , Alexander A Doinikov
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, 2013, 60 (1), ⟨10.1109/TUFFC.2013.2536⟩
Journal articles inserm-02438857v1

Bleomycin delivery into cancer cells in vitro with ultrasound and SonoVue® or BR14® microbubbles

Nerijus Lamanauskas , Novell Anthony , Jean-Michel Escoffre , Mindaugas Venslauskas , Saulius Satkauskas
Journal of Drug Targeting, 2013, 21 (4), pp.407-414. ⟨10.3109/1061186X.2012.761223⟩
Journal articles inserm-02438654v1

Hyaluronidase and Collagenase Increase the Transfection Efficiency of Gene Electrotransfer in Various Murine Tumors

Maja Cemazar , Muriel Golzio , Gregor Sersa , Jean-Michel Escoffre , Andrej Coer
Human Gene Therapy, 2012, 23 (1), pp.128-137. ⟨10.1089/hum.2011.073⟩
Journal articles inserm-02438934v1

New Insights in the Gene Electrotransfer Process: Evidence for the Involvement of the Plasmid DNA Topology

Jean-Michel Escoffre , Biliana Nikolova , Laetitia Mallet , Julien Henri , Cyril Favard
Current Gene Therapy, 2012, 12 (5), pp.417-422. ⟨10.2174/156652312802762554⟩
Journal articles inserm-02438890v1

Destabilizing Giant Vesicles with Electric Fields: An Overview of Current Applications

Thomas Portet , Chloé Mauroy , Vincent Démery , Thibault Houles , Jean-Michel Escoffre
Journal of Membrane Biology, 2012, 245 (9), pp.555-564. ⟨10.1007/s00232-012-9467-x⟩
Journal articles hal-00998473v1
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Electrochemotherapy: Progress and Prospects

Jean-Michel Escoffre , Marie-Pierre Rols
Current Pharmaceutical Design, 2012, 18 (23), pp.3406-3415. ⟨10.2174/138161212801227087⟩
Journal articles inserm-02438896v1
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Drug delivery by electropulsation: Recent developments in oncology

Teissié Justin , Jean-Michel Escoffre , Aurélie Paganin-Gioanni , Sophie Chabot , Elisabeth Bellard
International Journal of Pharmaceutics, 2012, 423 (1), pp.3-6. ⟨10.1016/j.ijpharm.2011.09.038⟩
Journal articles inserm-02438916v1

Cholesterol implications in plasmid DNA electrotransfer: Evidence for the involvement of endocytotic pathways

Christelle Rosazza , Émilie Phez , Jean-Michel Escoffre , Laurence Cézanne , Andreas Zumbusch
International Journal of Pharmaceutics, 2012, 423 (1), pp.134-143. ⟨10.1016/j.ijpharm.2011.05.024⟩
Journal articles inserm-02438956v1
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Electrochemotherapy: Progress and Prospects.

Jean-Michel Escoffre , Marie-Pierre Rols
Current Pharmaceutical Design, 2012, epub ahead of print
Journal articles inserm-00680356v1

The Actin Cytoskeleton Has an Active Role in the Electrotransfer of Plasmid DNA in Mammalian Cells

Christelle Rosazza , Jean-Michel Escoffre , Andreas Zumbusch , Marie-Pierre Rols
Molecular Therapy, 2011, 19 (5), pp.913-921. ⟨10.1038/mt.2010.303⟩
Journal articles inserm-02438983v1
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Electromediated formation of DNA complexes with cell membranes and its consequences for gene delivery

Jean-Michel Escoffre , Thomas Portet , Cyril Favard , Justin Teissié , David S. Dean
Biochimica et Biophysica Acta:Biomembranes, 2011, 1808 (6), pp.1538-1543. ⟨10.1016/j.bbamem.2010.10.009⟩
Journal articles hal-00998724v1

Doxorubicin Delivery into Tumor Cells with Ultrasound and Microbubbles

Jean-Michel Escoffre , Julien Piron , Novell Anthony , Ayache Bouakaz
Molecular Pharmaceutics, 2011, 8 (3), pp.799-806. ⟨10.1021/mp100397p⟩
Journal articles inserm-02438975v1
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Direct visualization at the single-cell level of siRNA electrotransfer into cancer cells

Aurélie Paganin-Gioanni , Elisabeth Bellard , Jean-Michel Escoffre , Marie-Pierre Rols , Teissié Justin
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (26), pp.10443-10447. ⟨10.1073/pnas.1103519108⟩
Journal articles inserm-02438940v1

In Vitro Gene Transfer by Electrosonoporation

Jean-Michel Escoffre , Kadija Kaddur , Marie-Pierre Rols , Ayache Bouakaz
Ultrasound in Medicine & Biology, 2010, 36 (10), pp.1746-1755. ⟨10.1016/j.ultrasmedbio.2010.06.019⟩
Journal articles inserm-02438997v1

Observations of the Mechanisms of Electromediated DNA Uptake - From Vesicles to Tissues

Muriel Golzio , Jean-Michel Escoffre , Thomas Portet , Chloé Mauroy , Justin Teissié
Current Gene Therapy, 2010, 10 (4), pp.256-266. ⟨10.2174/156652310791823461⟩
Journal articles hal-00999322v1

Gene Transfer: How Can the Biological Barriers Be Overcome?

Jean-Michel Escoffre , Justin Teissié , Marie-Pierre Rols
Journal of Membrane Biology, 2010, 236 (1), pp.61-74. ⟨10.1007/s00232-010-9275-0⟩
Journal articles inserm-02439003v1

Electro-mediated gene transfer and expression are controlled by the life-time of DNA/membrane complex formation

Cécile Faurie , Matej Reberšek , Muriel Golzio , Masa Kanduser , Jean-Michel Escoffre
The Journal of Gene Medicine, 2010, 12 (1), pp.117-125. ⟨10.1002/jgm.1414⟩
Journal articles inserm-02439034v1

Visualization of Membrane Loss during the Shrinkage of Giant Vesicles under Electropulsation

Thomas Portet , Franc Camps I Febrer , Jean-Michel Escoffre , Cyril Favard , Marie-Pierre Rols
Biophysical Journal, 2009, 96 (10), pp.4109-4121. ⟨10.1016/j.bpj.2009.02.063⟩
Journal articles inserm-02439154v1

A 3D in vitro spheroid model as a way to study the mechanisms of electroporation

Luc Wasungu , Jean-Michel Escoffre , Annie Valette , Justin Teissié , Marie-Pierre Rols
International Journal of Pharmaceutics, 2009, 379 (2), pp.278-284. ⟨10.1016/j.ijpharm.2009.03.035⟩
Journal articles inserm-02439046v1

What is (Still not) Known of the Mechanism by Which Electroporation Mediates Gene Transfer and Expression in Cells and Tissues

Jean-Michel Escoffre , Thomas Portet , Luc Wasungu , Teissié Justin , David S. Dean
Molecular Biotechnology, 2009, 41 (3), pp.286-295. ⟨10.1007/s12033-008-9121-0⟩
Journal articles inserm-02439136v1

Gene electrotransfer: from biophysical mechanisms to in vivo applications. Part 2 - In vivo developments and present clinical applications

Jean-Michel Escoffre , Chloé Mauroy , Thomas Portet , Luc Wasungu , Aurélie Paganin-Gioanni
Biophysical Reviews and Letters, 2009, 1 (4), pp.185-191. ⟨10.1007/s12551-009-0019-2⟩
Journal articles inserm-02439026v1

Transgene expression of transfected supercoiled plasmid DNA concatemers in mammalian cells

Jean-Michel Escoffre , Elisabeth Bellard , Muriel Golzio , Justin Teissié , Marie-Pierre Rols
The Journal of Gene Medicine, 2009, 11 (11), pp.1071-1073. ⟨10.1002/jgm.1384⟩
Journal articles inserm-02439039v1

Long-lasting In vivo Gene Silencing by Electrotransfer of shRNA Expressing Plasmid

Jean-Michel Escoffre , Arnaud Debin , Jean-Paul Reynes , Daniel Drocourt , Gérard Tiraby
Technology in Cancer Research and Treatment, 2008, 7 (2), pp.109-116. ⟨10.1177/153303460800700203⟩
Journal articles inserm-02439064v1

Membrane perturbation by an external electric field: a mechanism to permit molecular uptake

Jean-Michel Escoffre , David S. Dean , Marie Hubert , Marie-Pierre Rols , Cyril Favard
European Biophysics Journal, 2007, 36 (8), pp.973-983. ⟨10.1007/s00249-007-0194-7⟩
Journal articles inserm-02439124v1

In vivo imaging of tumor growth after electrochemotherapy with cisplatin

Maja Cemazar , Muriel Golzio , Jean-Michel Escoffre , Bettina Couderc , Gregor Sersa
Biochemical and Biophysical Research Communications, 2006, 348 (3), pp.997-1002. ⟨10.1016/j.bbrc.2006.07.132⟩
Journal articles inserm-02439075v1

A fluid dynamic model for quantitative contrast-enhanced ultrasound imaging: validation for the assessment of uteroplacental perfusion

Baudouin Denis de Senneville , Anthony Novell , Chloé J. Arthuis , Vanda Mendes , Paul-Armand Dujardin
IEEE International Ultrasonics Symposium, Oct 2018, Kobe, Japan
Conference papers hal-01963238v1
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Analysis of Contrast-Enhanced Ultrasound using fluid dynamic

Baudouin Denis de Senneville , Anthony Novell , Chloé J. Arthuis , Vanda Mendes , Paul-Armand Dujardin
IEEE International Symposium on Biomedical Imaging (ISBI), Apr 2018, Washington, United States
Conference papers hal-01963092v1
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Involvement of cytoskeleton in sonoporation and drug delivery

Aya Zeghimi , Jean-Michel Escoffre , Ayache Bouakaz
2014 IEEE International Ultrasonics Symposium, Sep 2014, Chicago (IL), United States. pp.850-853, ⟨10.1109/ultsym.2014.0209⟩
Conference papers hal-04280322v1
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Lattice of nonlinear coupled oscillators: An acousto-mechanical analogy of gas microbubble

Jennifer Chaline , Ayache Bouakaz , Jean-Michel Escoffre , Victor Sanchez-Morcillo , Noe Jimenez
2014 IEEE International Ultrasonics Symposium, Sep 2014, Chicago (IL), United States. pp.2277-2279, ⟨10.1109/ultsym.2014.0567⟩
Conference papers hal-04280323v1
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Ultrastructural sonoporation bio-effects: Comparative study on two human cancer cell lines

Aya Zeghimi , Jean-Michel Escoffre , Ayache Bouakaz
2013 IEEE International Ultrasonics Symposium (IUS), Jul 2013, Prague, Czech Republic. pp.61-64, ⟨10.1109/ultsym.2013.0016⟩
Conference papers hal-04280326v1
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Ultrastructural modifications of cell membranes and organelles induced by sonoporation

Aya Zeghimi , Rustem Uzbekov , Brigite Arbeille , Jean-Michel Escoffre , Ayache Bouakaz
2012 IEEE International Ultrasonics Symposium (IUS), Oct 2012, Dresden (Germany), Germany. pp.2045-2048, ⟨10.1109/ultsym.2012.0511⟩
Conference papers hal-04280327v1
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Blood-brain barrier disruption with focused ultrasound enhances delivery of dopamine transporter tracer (PE2I) into the brain

Jean-Michel Escoffre , Sophie Serrière , Sylvie Bodard , Anthony Novell , Sylvie Chalon
Acoustics 2012, Apr 2012, Nantes, France
Conference papers hal-00810925v1
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Doxorubicin-liposomes loaded microbubbles for ultrasound-triggered doxorubicin delivery

Jean-Michel Escoffre , Anthony Novell , Bart Geers , Ine Lentacker , Ayache Bouakaz
Acoustics 2012, Apr 2012, Nantes, France
Conference papers hal-00810695v1
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Irinotecan delivery by microbubble-assisted ultrasound - A pilot preclinical study

Jean-Michel Escoffre , Anthony Novell , Sophie Serrière , Ayache Bouakaz
12th International Symposium on Therapeutic Ultrasound, Jun 2012, Heidelberg (Germany), Germany. pp.40-45, ⟨10.1063/1.4769914⟩
Conference papers hal-04280331v1
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Role of thermal and mechanical effects on drug release from thermosensitive nanocarriers

Anthony Novell , Jean-Michel Escoffre , Chantal Al-Sabbagh , Christophoros Mannaris , Elias Fattal
2012 IEEE International Ultrasonics Symposium, Oct 2012, Dresden (GERMANY), Germany. pp.1873-1876, ⟨10.1109/ultsym.2012.0470⟩
Conference papers hal-04280329v1
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High-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomes

Jean-Michel Escoffre , Christophoros Mannaris , Anthony Novell , Laëtitia Rioc , Marie-Edith Meyre
11TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, Apr 2011, New York, NY, United States. pp.81-87, ⟨10.1063/1.4757315⟩
Conference papers hal-04280336v1
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Enhanced gene transfection using ultrasound and Vevo Micromarker ® microbubbles

Julien Piron , Jean-Michel Escoffre , Kadija Kaddur , Anthony Novell , Ayache Bouakaz
2010 IEEE International Ultrasonics Symposium, Oct 2010, San Diego, United States. ⟨10.1109/ULTSYM.2010.5935896⟩
Conference papers hal-04280337v1
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In vivo imaging of siRNA electrotransfer and silencing in different organs

Aurélie Paganin-Gioanni , Jean-Michel Escoffre , Laurent Mazzolini , Marie-Pierre Rols , Justin Teissie
11th Mediterranean Conference on Medical and Biological Engineering and Computing 2007, Jun 2007, Ljubljana, Slovenia
Conference papers hal-04280340v1
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Mécanismes moléculaires et cellulaire de l'électrotransfert de plasmides in vitro

Jean-Michel Escoffre
Sciences du Vivant [q-bio]. Université Paul Sabatier (Toulouse 3), 2010. Français. ⟨NNT : ⟩
Theses tel-04280318v1