Jean-Michel Escoffre
Présentation
Jean-Michel Escoffre earned his M.Sc. degrees in Vectorology, Gene Therapy, Vaccinology and in Structure/Function in Macromolecules and Living Processes in 2005 and 2006 respectively, at the University Paul-Sabatier (Toulouse, France). He obtained his Ph.D. degrees in Cell Biophysics in 2010 at the Institute of Pharmacology and Structural Biology (IPBS/CNRS, UMR 5089) and University Paul-Sabatier. During his PhD fellowship, he investigated the molecular and cellular mechanisms of gene electrotransfer. For his first post-doctoral fellowship, he joined the Institute of Imaging and Brain of the French Institute for Health and Medical Science (Inserm, UMR 930) in Tours, France (2010-2013). He worked in the fields of gene and drug delivery using microbubble-assisted ultrasound. Then, he joined the Imaging Division at UMC Utrecht, The Netherlands. His main research interest was the development of HIFU-mediated anticancer immunotherapy (2013-2015). He is currently pursuing his research as Inserm Senior Researcher at the Institute of Imaging and Brain of the French Institute for Health and Medical Science (Inserm, University of Tours) in Tours, France. His main research interest lie in the fields of biodrug delivery using ultrasound-guided therapeutic ultrasound. Jean-Michel Escoffre is also expert in Diagnostic Tools, Therapies and Public Health for many national, European and international public and private agencies.
Compétences
Publications
Publications
Formation de Faisceaux Adaptée à une Sonde Bimodale pour la Sonoporation Guidée par UltrasonsCFA 2025 - 17e Congrès Français d'Acoustique, Société Française d'Acoustique (SFA), Apr 2025, Paris, France |
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A Dual-Core Ultrasound Probe For Image-Guided Sonoporation: Application to Anti-Cancer Immunotherapy2022 IEEE International Ultrasonics Symposium (IUS), Oct 2022, Venice, Italy. pp.1-4, ⟨10.1109/IUS54386.2022.9958841⟩ |
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Irinotecan delivery by microbubble-assisted ultrasound - A pilot preclinical study12th International Symposium on Therapeutic Ultrasound, Jun 2012, Heidelberg (Germany), Germany. pp.40-45, ⟨10.1063/1.4769914⟩ |
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Analysis of Contrast-Enhanced Ultrasound using fluid dynamicIEEE International Symposium on Biomedical Imaging (ISBI), Apr 2018, Washington, United States |
A fluid dynamic model for quantitative contrast-enhanced ultrasound imaging: validation for the assessment of uteroplacental perfusionIEEE International Ultrasonics Symposium, Oct 2018, Kobe, Japan |
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Lattice of nonlinear coupled oscillators: An acousto-mechanical analogy of gas microbubble2014 IEEE International Ultrasonics Symposium, Sep 2014, Chicago (IL), United States. pp.2277-2279, ⟨10.1109/ultsym.2014.0567⟩ |
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Involvement of cytoskeleton in sonoporation and drug delivery2014 IEEE International Ultrasonics Symposium, Sep 2014, Chicago (IL), United States. pp.850-853, ⟨10.1109/ultsym.2014.0209⟩ |
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Ultrastructural sonoporation bio-effects: Comparative study on two human cancer cell lines2013 IEEE International Ultrasonics Symposium (IUS), Jul 2013, Prague, Czech Republic. pp.61-64, ⟨10.1109/ultsym.2013.0016⟩ |
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Doxorubicin-liposomes loaded microbubbles for ultrasound-triggered doxorubicin deliveryAcoustics 2012, Apr 2012, Nantes, France |
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Role of thermal and mechanical effects on drug release from thermosensitive nanocarriers2012 IEEE International Ultrasonics Symposium, Oct 2012, Dresden (GERMANY), Germany. pp.1873-1876, ⟨10.1109/ultsym.2012.0470⟩ |
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High-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomes11TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND, Apr 2011, New York, NY, United States. pp.81-87, ⟨10.1063/1.4757315⟩ |
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Blood-brain barrier disruption with focused ultrasound enhances delivery of dopamine transporter tracer (PE2I) into the brainAcoustics 2012, Apr 2012, Nantes, France |
Delivery of dopamine transporter tracer (PE2I) through blood brain barrier with ultrasound and microbubbles11. International Symposium on Therapeutic Ultrasound, American Institute of Physics. Melville, USA., Apr 2011, New York, United States. ⟨10.1063/1.4757355⟩ |
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Ultrastructural modifications of cell membranes and organelles induced by sonoporation2012 IEEE International Ultrasonics Symposium (IUS), Oct 2012, Dresden (Germany), Germany. pp.2045-2048, ⟨10.1109/ultsym.2012.0511⟩ |
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Enhanced gene transfection using ultrasound and Vevo Micromarker ® microbubbles2010 IEEE International Ultrasonics Symposium, Oct 2010, San Diego, United States. ⟨10.1109/ULTSYM.2010.5935896⟩ |
Dynamic of DNA/membrane interaction after electrotransfection process.XIIIth Meeting of Study Group of Molecules – Membranes Interactions, 2008, Strasbourg, France |
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In vivo imaging of siRNA electrotransfer and silencing in different organs11th Mediterranean Conference on Medical and Biological Engineering and Computing 2007, Jun 2007, Ljubljana, Slovenia |
DNA electrotransfection: effects of electric fields on cell membraneXIXth International Symposium of BioElectrochemistry Society, 2007, Toulouse, France |
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New insights on mechanisms of electrogenetransferXXIIth Scientific days of Thematic Group of Research on Vectorisation., 2007, Strasbourg, France |
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DNA electrotransfection: Electric field effects on cell membraneVIth National Congress of Francophone Society of Cell and Gene Therapy, 2007, Giens, France |
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DNA/membrane interaction: a key step of electrotransfectionVIth European Biophysics Congress, 2006, London, United Kingdom |
Therapeutic Ultrasound, 2016, ⟨10.1007/978-3-319-22536-4⟩ |
Bubble-Assisted Ultrasound: Application in Immunotherapy and VaccinationTherapeutic Ultrasound, In press, ⟨10.1007/978-3-319-22536-4_14⟩ |
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Encapsulated Bubble Dynamics in Imaging and TherapyBubble Dynamics and Shock Waves, Springer Berlin Heidelberg, pp.259-289, 2013, 978-3-642-34296-7. ⟨10.1007/978-3-642-34297-4_9⟩ |
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shRNA-Mediated Gene Knockdown in Skeletal MuscleMyogenesis, pp.491-501, 2012, ⟨10.1007/978-1-61779-343-1_29⟩ |
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Electrotransfer of Plasmid DNAClinical Aspects of Electroporation, Springer New York, pp.145-157, 2011, ⟨10.1007/978-1-4419-8363-3_13⟩ |
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Gene electrotransfer: from biophysical mechanisms to in vivo applications. Part 1 . Biophysical mechanismsAdvanced Electroporation Techniques in Biology and Medicine, 1 (4), pp.177-184, 2009, ⟨10.1007/s12551-009-0022-7⟩ |
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Délivrance de molécules thérapeutiques par sonoporation dans un modèle murin de métastases hépatiques de cancer colorectalSciences du Vivant [q-bio]. Université de Tours (UT), Tours, FRA, 2024. Français. ⟨NNT : ⟩ |
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Influence de paramètres acoustiques sur l’efficacité de la neurostimulation ultrasonore : dispositif expérimental et étude précliniqueSciences du Vivant [q-bio]. Université de Tours (UT), Tours, FRA, 2022. Français. ⟨NNT : ⟩ |
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Etude des conséquences neurophysiologiques de l’ouverture de la barrière hémato-encéphalique par sonoporationSciences du Vivant [q-bio]. Université de Tours (UT), Tours, FRA, 2022. Français. ⟨NNT : ⟩ |
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Mécanismes moléculaires et cellulaire de l'électrotransfert de plasmides in vitroSciences du Vivant [q-bio]. Université Paul Sabatier (Toulouse 3), 2010. Français. ⟨NNT : ⟩ |