Jean-François FAIVRE

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Publications

Ion channel expression in intrinsic cardiac neurons: new players in cardiac channelopathies?

Jocelyn Bescond , Jean-François Faivre , Alice Jean , P. Bois , Aurelien Chatelier

Biochimica et Biophysica Acta - Molecular Cell Research, 2025, 1872 (6), pp.119983. ⟨10.1016/j.bbamcr.2025.119983⟩

Article dans une revue hal-05319934v1

Excitability properties of cardiac calbindin neurons: Identifying a unique neuronal population

Guénaëlle Lizot , Jocelyn Bescond , Yves de Koninck , Mohamed Chahine , Patrick Bois et al.

Heart Rhythm, In press, ⟨10.1016/j.hrthm.2025.04.007⟩

Article dans une revue hal-05319939v1

Combined cardiovascular effects of ovariectomy and high-intensity interval training in female spontaneously hypertensive rats

Amandine Krzesiak , Carina Enea , Jean-François Faivre , Jocelyn Bescond , Clarisse Vanderbrouck et al.

Journal of Applied Physiology, 2024, 136 (5), pp.1195-1208. ⟨10.1152/japplphysiol.00518.2023⟩

Article dans une revue hal-04645754v1

Pro-inflammatory cytokine secretion induced by amyloid transthyretin in human cardiac fibroblasts

Christophe Magaud , Thomas Harnois , Stephane Sebille , Aurelien Chatelier , Jean-Francois Faivre et al.

Biochemical and Biophysical Research Communications, 2023, 642, pp.83-89. ⟨10.1016/j.bbrc.2022.12.027⟩

Article dans une revue hal-04053575v1

Pro-inflammatory cytokine secretion induced by amyloid transthyretin in human cardiac fibroblasts

Christophe Magaud , Thomas Harnois , Stephane Sebille , Aurelien Chatelier , Jean-Francois Faivre et al.

Biochemical and Biophysical Research Communications, 2023, 642, pp.83-89. ⟨10.1016/j.bbrc.2022.12.027⟩

Article dans une revue hal-05485022v1
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Molecular and functional characterization of the mouse intrinsic cardiac nervous system

Guénaëlle Lizot , Côme Pasqualin , Audrey Tissot , Stephane Pagès , Jean-François Faivre et al.

Heart Rhythm, 2022, ⟨10.1016/j.hrthm.2022.04.012⟩

Article dans une revue hal-03715785v1
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Polyunsaturated Phospholipids Increase Cell Resilience to Mechanical Constraints

Linette Kadri , Amélie Bacle , Spiro Khoury , Clarisse Vandebrouck , Jocelyn Bescond et al.

Cells, 2021, 10 (4), pp.937. ⟨10.3390/cells10040937⟩

Article dans une revue hal-03715789v1

TRPM4 non-selective cation channel in human atrial fibroblast growth

Christophe Simard , Christophe Magaud , Racim Adjlane , Quentin Dupas , Laurent Sallé et al.

Pflügers Archiv European Journal of Physiology, 2020, 472 (12), pp.1719-1732. ⟨10.1007/s00424-020-02476-0⟩

Article dans une revue hal-03715736v1
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A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction

Amélie Bacle , Linette Kadri , Spiro Khoury , Romain Ferru-Clément , Jean-François Faivre et al.

Disease Models & Mechanisms, 2020, 13 (6), pp.dmm043927. ⟨10.1242/dmm.043927⟩

Article dans une revue hal-02962304v1
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In vitro differentiation of W8B2 + human cardiac stem cells: gene expression of ionic channels and spontaneous calcium activity

Oualid Ayad , Zeina Al Sayed , Stéphane Sebille , Christophe Magaud , Charles-Albert Chapotte-Baldacci et al.

Cellular and Molecular Biology Letters, 2020, ⟨10.1186/s11658-020-00242-9⟩

Article dans une revue hal-03012564v1

TRPM4 non-selective cation channel in human atrial fibroblast growth

Christophe Simard , Christophe Magaud , Racim Adjlane , Quentin Dupas , Laurent Sallé et al.

Pflügers Archiv European Journal of Physiology, 2020, 472 (12), pp.1719-1732. ⟨10.1007/s00424-020-02476-0⟩

Article dans une revue hal-05485051v1
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In vitro differentiation of W8B2+ human cardiac stem cells: gene expression of ionic channels and spontaneous calcium activity

Oualid Ayad , Zeina Al Sayed , Stéphane Sebille , Christophe Magaud , Charles-Albert Chapotte-Baldacci et al.

Cellular and Molecular Biology Letters, 2020, 25 (1), pp.50. ⟨10.1186/s11658-020-00242-9⟩

Article dans une revue hal-05485167v1
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Long-term intake of phenolic compounds attenuates age-related cardiac remodeling

Stéphanie Chacar , Joelle Hajal , Youakim Saliba , Patrick Bois , Nicolas Louka et al.

Aging Cell, 2019, 18 (2), pp.e12894. ⟨10.1111/acel.12894⟩

Article dans une revue hal-02457531v1

Role of Cardiac IKs Current in Repolarization Reserve Process During Late Sodium Current (INaL) Activation

Richard Printemps , Céline Salvetat , Jean-françois Faivre , Marie Le Grand , Patrick Bois et al.

Cardiology and Cardiovascular Medicine, 2019, 03 (04), pp.168-185. ⟨10.26502/fccm.92920065⟩

Article dans une revue hal-05319944v1

The Impact of Long-Term Intake of Phenolic Compounds-Rich Grape Pomace on Rat Gut Microbiota

Stéphanie Chacar , Tarek Itani , Joelle Hajal , Youakim Saliba , Nicolas Louka et al.

Journal of Food Science, 2018, 83 (1), pp.246-251. ⟨10.1111/1750-3841.14006⟩

Article dans une revue hal-03715801v1
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Identification of Phenolic Compounds-Rich Grape Pomace Extracts Urine Metabolites and Correlation with Gut Microbiota Modulation

Stéphanie Chacar , Mehrad Tarighi , Nassim Fares , Jean-François Faivre , Nicolas Louka et al.

Antioxidants , 2018, 7 (6), pp.75. ⟨10.3390/antiox7060075⟩

Article dans une revue hal-03715797v1

Functional BKCa channel in human resident cardiac stem cells expressing W8B2

Oualid Ayad , Christophe Magaud , Stéphane Sebille , Jocelyn Bescond , Chloé Mimbimi et al.

FEBS Journal, 2017, 285 (3), pp.518-530. ⟨10.1111/febs.14352⟩

Article dans une revue hal-05485074v1

Functional BKCa channel in human resident cardiac stem cells expressing W8B2

Oualid Ayad , Christophe Magaud , Stéphane Sebille , Jocelyn Bescond , Chloé Mimbimi et al.

FEBS Journal, 2017, 285 (3), pp.518-530. ⟨10.1111/febs.14352⟩

Article dans une revue hal-02136052v1

Basic Signaling in Cardiac Fibroblasts

Stéphanie Chacar , Nassim Farès , Patrick Bois , Jean-François Faivre

Journal of Cellular Physiology, 2017, 232 (4), pp.725-730. ⟨10.1002/jcp.25624⟩

Article dans une revue hal-01436828v1
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Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies

Xavier Ligneau , Rashmi Shah , Isabelle Berrebi-Bertrand , Gary Mirams , Philippe Robert et al.

British Journal of Pharmacology, 2017, 174 (23), pp.4449-4463. ⟨10.1111/bph.14047⟩

Article dans une revue hal-03715804v1

Basic Signaling in Cardiac Fibroblasts

Stéphanie Chacar , Nassim Farès , Patrick Bois , Jean-François Faivre

Journal of Cellular Physiology, 2016, 232 (4), pp.725-730. ⟨10.1002/jcp.25624⟩

Article dans une revue hal-05485094v1

Effects of Atrial Natriuretic Peptide on Rat Ventricular Fibroblasts During Differentiation Into Myofibroblasts

M. Moubarak , C. Magaud , Y. Saliba , A. Chatelier , P. Bois et al.

Physiological Research, 2015, pp.495-503. ⟨10.33549/physiolres.932839⟩

Article dans une revue hal-03716567v1

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts.

Antoun El Chemaly , Caroline Norez , Christophe Magaud , Jocelyn Bescond , Aurelien Chatelier et al.

Journal of Molecular and Cellular Cardiology, 2014, 68, pp.12-9. ⟨10.1016/j.yjmcc.2013.12.027⟩

Article dans une revue istex hal-00990329v1

Ultrastructural and functional alterations of EC coupling elements in mdx cardiomyocytes: an analysis from membrane surface to depth.

Charlotte Lorin , Mélanie Gueffier , Patrick Bois , Jean-François Faivre , Christian Cognard et al.

Cell Biochemistry and Biophysics, 2013, 66 (3), pp.723-36. ⟨10.1007/s12013-013-9517-8⟩

Article dans une revue istex hal-00992875v1

A distinct de novo expression of Nav1.5 sodium channels in human atrial fibroblasts differentiated into myofibroblasts.

Aurélien Chatelier , Aurélie Mercier , Boris Tremblier , Olivier Thériault , Majed Moubarak et al.

The Journal of Physiology, 2012, 590 (Pt 17), pp.4307-19. ⟨10.1113/jphysiol.2012.233593⟩

Article dans une revue hal-00991608v1

The β1-subunit of Na(v)1.5 cardiac sodium channel is required for a dominant negative effect through α-α interaction.

Aurélie Mercier , Romain Clément , Thomas Harnois , Nicolas Bourmeyster , Jean-François Faivre et al.

PLoS ONE, 2012, 7 (11), pp.e48690. ⟨10.1371/journal.pone.0048690⟩

Article dans une revue hal-00992871v1

Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts

Najate Benamer , Nassim Fares , Patrick Bois , Jean-François Faivre

Biochemical and Biophysical Research Communications, 2011, 408 (1), pp.6-11. ⟨10.1016/j.bbrc.2011.03.072⟩

Article dans une revue istex hal-03716592v1

Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks).

Joffrey Ducroq , H. Moha Ou Maati , S. Guilbot , S. Dilly , E. Laemmel et al.

British Journal of Pharmacology, 2010, 159 (1), pp.93-101. ⟨10.1111/j.1476-5381.2009.00371.x⟩

Article dans une revue hal-00561579v1

Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts

Najate Benamer , Hamid Moha Ou Maati , Sophie Demolombe , Anne Cantereau , Adriana Delwail et al.

Journal of Molecular and Cellular Cardiology, 2009, 46 (4), pp.508-517. ⟨10.1016/j.yjmcc.2008.12.016⟩

Article dans une revue istex hal-00397628v1

Implication of connexins 40 and 43 in functional coupling between mouse cardiac fibroblasts in primary culture

Claire Louault , Najate Benamer , Jean-François Faivre , Daniel Potreau , Jocelyn Bescond

Biochimica et Biophysica Acta:Biomembranes, 2008, 1778 (10), pp.2097-2104. ⟨10.1016/j.bbamem.2008.04.005⟩

Article dans une revue istex hal-00397613v1

Zatebradine: Pharmacological Activity and Potential Therapeutic Benefit of Sino‐atrial Node Modulators

Antoine Bril , Jean François Faivre , Bernard Gout

Cardiovascular Drug Reviews, 2007, 13 (4), pp.365-378. ⟨10.1111/j.1527-3466.1995.tb00220.x⟩

Article dans une revue hal-05320210v1

Tedisamil

Jean-François Faivre , Bernard Gout , Antoine Bril

Cardiovascular Drug Reviews, 2007, 13 (1), pp.33-50. ⟨10.1111/j.1527-3466.1995.tb00212.x⟩

Article dans une revue hal-05320221v1

MOLECULAR REGULATION AND PHARMACOLOGY OF PACEMAKER CHANNELS

Patrick Bois , Romain Guinamard , Antoun El Chemaly , Jean François Faivre , Jocelyn Bescond

Current Pharmaceutical Design, 2007, 13 (23), pp.2338-2349

Article dans une revue hal-00394274v1

A voltage-activated proton current in human cardiac fibroblasts

Antoun El Chemaly , Romain Guinamard , Marie Demion , Nassim Fares , Victor Jebara et al.

Biochemical and Biophysical Research Communications, 2006, 340 (2), pp.512-516. ⟨10.1016/j.bbrc.2005.12.038⟩

Article dans une revue istex hal-05319956v1

hKv4.3 Channel Characterization and Regulation by Calcium Channel Antagonists

Thierry P.G. Calmels , Jean-François Faivre , Brigitte Cheval , Jean-Luc Javré , Sabine Rouanet et al.

Biochemical and Biophysical Research Communications, 2001, 281 (2), pp.452-460. ⟨10.1006/bbrc.2001.4396⟩

Article dans une revue istex hal-05320042v1

ATP‐sensitive K channels in heart muscle Spare channels

Ian Findlay , Jean-François Faivre

FEBS Letters, 2001, 279 (1), pp.95-97. ⟨10.1016/0014-5793(91)80259-6⟩

Article dans une revue hal-05322379v1

Characterisation of Kv4.3 in HEK293 cells: comparison with the rat ventricular transient outward potassium current

Jean-François Faivre , Thierry P.G. Calmels , Sabine Rouanet , Jean-Luc Javré , Brigitte Cheval et al.

Cardiovascular Research, 1999, 41 (1), pp.188-199. ⟨10.1016/s0008-6363(98)00215-6⟩

Article dans une revue hal-05319989v1

Electrophysiological characterization of BRL-32872 in canine Purkinje fiber and ventricular muscle

Jean-François Faivre , Marie-Claire Forest , Bernard Gout , Antoine Bril

European Journal of Pharmacology, 1999, 383 (2), pp.215-222. ⟨10.1016/s0014-2999(99)00614-7⟩

Article dans une revue istex hal-05319995v1

Identification and Characterization of cvHsp

Stéphane Krief , Jean-François Faivre , Philippe Robert , Bertrand Le Douarin , Nicole Brument-Larignon et al.

Journal of Biological Chemistry, 1999, 274 (51), pp.36592-36600. ⟨10.1074/jbc.274.51.36592⟩

Article dans une revue hal-05319999v1

Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide

A Bril , M.-C. Forest , B. Cheval , J-F Faivre

Cardiovascular Research, 1998, 37 (1), pp.130-140. ⟨10.1016/s0008-6363(97)00216-2⟩

Article dans une revue hal-05320072v1

Comparative Effects of Glibenclamide, Tedisamil, Dofetilide, E-4031, and BRL-32872 on Protein Kinase A-Activated Chloride Current in Guinea Pig Ventricular Myocytes

Jean-François Faivre , Sabine Rouanet , Antoine Bril

Journal of Cardiovascular Pharmacology, 1998, 31 (4), pp.551-557. ⟨10.1097/00005344-199804000-00013⟩

Article dans une revue hal-05320055v1

Synthesis, electrophysiological properties and analysis of structural requirements of a novel class of antiarrhythmic agents with potassium and calcium channel blocking properties

Guy Nadler , Jean-François Faivre , Marie-Claire Forest , Brigitte Cheval , Michel Martin et al.

Bioorganic and Medicinal Chemistry, 1998, 6 (11), pp.1993-2011. ⟨10.1016/s0968-0896(98)00166-7⟩

Article dans une revue istex hal-05320049v1

Combined potassium and calcium channel antagonism for anti-arrhythmic therapy

A. Bril , J.-F. Faivre , B Gout

Ion Channel Modulators, 1997, 2 (6), pp.189-194

Article dans une revue hal-05320203v1

The cardiac chloride channels as molecular targets for antiarrhythmic therapy

Jf Faivre , A Bril

Pharmacology Reviews and Communications, 1997, 9, pp.61-70

Article dans une revue hal-05320160v1

cADP-ribose releases Ca2+ from cardiac sarcoplasmic reticulum independently of ryanodine receptor

P. Lahouratate , J. Guibert , J.F. Faivre

AJP - Heart and Circulatory Physiology, 1997, 273 (3), pp.H1082-H1089. ⟨10.1152/ajpheart.1997.273.3.H1082⟩

Article dans une revue hal-05320111v1

Synthesis of conformationally constrained analogues of BRL-32872. Determination of stereochemistry and related pharmacological properties

Michel Souchet , Marie-Claire Forest , Ute Gerhard , Richard Smith , Brigitte Cheval et al.

Bioorganic and Medicinal Chemistry Letters, 1997, 7 (15), pp.1989-1994. ⟨10.1016/S0960-894X(97)00349-1⟩

Article dans une revue istex hal-05320103v1

Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: experimental profile of BRL-32872.

A Bril , B Gout , M Bonhomme , L Landais , J Faivre et al.

Journal of Pharmacology and Experimental Therapeutics, 1996, 276 (2), pp.637-46. ⟨10.1016/S0022-3565(25)12319-7⟩

Article dans une revue hal-05320207v1

Electrophysiological effect of BRL-32872, a novel antiarrhythmic agent with potassium and calcium channel blocking properties, in guinea pig cardiac isolated preparations.

A Bril , J.-F. Faivre , M Forest , B Cheval , B Gout et al.

Journal of Pharmacology and Experimental Therapeutics, 1995, 273 (3), pp.1264-72

Article dans une revue hal-05320242v1

Effects of thiol-modifying agents on KATP channels in guinea pig ventricular cells

W. A. Coetzee , T. Y. Nakamura , Jean-François Faivre

AJP - Heart and Circulatory Physiology, 1995, 269 (5), pp.H1625-H1633. ⟨10.1152/ajpheart.1995.269.5.H1625⟩

Article dans une revue hal-05320225v1

Activation of ATP-sensitive K channels by a K channel opener (SR 44866) and the effect upon electrical and mechanical activity of frog skeletal muscle

M. -P. Sauviat , E. Ecault , J.-F. Faivre , I. Findlay

Pflügers Archiv European Journal of Physiology, 1991, 418 (3), pp.261-265. ⟨10.1007/BF00370524⟩

Article dans une revue istex hal-05322372v1

Action potential duration and activation of ATP-sensitive potassium current in isolated guinea-pig ventricular myocytes

Jean-François Faivre , Ian Findlay

Biochimica et Biophysica Acta:Biomembranes, 1990, 1029 (1), pp.167-172. ⟨10.1016/0005-2736(90)90450-3⟩

Article dans une revue istex hal-05322382v1

Effect of maitotoxin on calcium current and background inward current in isolated ventricular rat myocytes

Jean-François Faivre , Edith Deroubaix , Alain Coulombe , Anne-Marie Legrand , Edouard Coraboeuf

Toxicon, 1990, 28 (8), pp.925-937. ⟨10.1016/0041-0101(90)90022-y⟩

Article dans une revue istex hal-05322392v1

Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle

J.-F. Faivre , I. Findlay

Biochimica et Biophysica Acta:Biomembranes, 1989, 984 (1), pp.1-5. ⟨10.1016/0005-2736(89)90334-9⟩

Article dans une revue istex hal-05322396v1

Two types of transient outward currents in adult human atrial cells

D. Escande , A. Coulombe , J.F. Faivre , E. Deroubaix , E. Coraboeuf

AJP - Heart and Circulatory Physiology, 1987, 252 (1), pp.H142-H148. ⟨10.1152/ajpheart.1987.252.1.H142⟩

Article dans une revue hal-05322399v1

Characteristics of the time-dependent slow inward current in adult human atrial single myocytes

D Escande , A Coulombe , J.F. Faivre , E Coraboeuf

Journal of Molecular and Cellular Cardiology, 1986, 18 (5), pp.547-551. ⟨10.1016/s0022-2828(86)80920-8⟩

Article dans une revue istex hal-05322405v1

Electrophysiological characterization of mouse intracardiac calbindin neurons

Lizot Guénaëlle , Jocelyn Bescond , Patrick Bois , Jean-François Faivre , Aurélien Chatelier

Annual Meeting Biophysical Society, Biophysical Journal, 121 (3), pp.231a, 2022, ⟨10.1016/j.bpj.2021.11.1557⟩

Proceedings/Recueil des communications hal-04484011v1

Electrophysiological characterization of mouse intracardiac calbindin neurons

Guénaëlle Lizot , Jocelyn Bescond , Patrick Bois , Jean-François Faivre , Aurélien Chatelier

Printemps de la Cardiologie, Archives of Cardiovascular Diseases Supplements, 14 (2), pp.211-212, 2022, ⟨10.1016/j.acvdsp.2022.04.132⟩

Proceedings/Recueil des communications hal-04484023v1

Pharmacology of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Patrick Bois , Aurelien Chatelier , Jocelyn Bescond , Jean-François Faivre

Ion Channels and Their Inhibitors, pp.33-51, 2011, 978-3-642-19921-9

Chapitre d'ouvrage hal-04486633v1

Canal pacemaker : nouvelle perspective thérapeutique

Patrick Bois , Jean-François Faivre

Archives des maladies du coeur et des vaisseaux, Société Française de Cardiologie, pp.30-35, 2008

Chapitre d'ouvrage hal-00394403v1

Mécanismes ioniques responsables de l'automatisme cardiaque

Patrick Bois , Mohammad Rahmati , Jocelyn Bescond , Jean François Faivre

biologie et pathologie du cœur et des vaisseaux, Edition John Libbery, pp.12-21, 2008

Chapitre d'ouvrage hal-00394373v1

Spontaneous and thiol-group induced changes in ATP-sensitivity of KATP channels of guinea-pig ventricular myocytes.

T.Y. Nakamura , J.-F. Faivre , A. Bril , D.J. Hearse , W.A. Coetzee

J. Vereecke; P.P. van Bogaert; F. Verdonck. Potassium Channels in Normal and Pathological Conditions, Leuven University Press, pp.330-333, 1995

Chapitre d'ouvrage hal-05320240v1