Access content directly

Jean-Jacques HELESBEUX

89
Documents

Publications

From Phloridzin towards Semisynthetic Bioactive Dihydrochalcones

Antonio Cala Peralta , Fabian Mayr , Guillaume Viault , Veronika Temml , Daniela Schuster
27th Annual GP2A Medicinal Chemistry Conference, Aug 2019, Notthingham, United Kingdom. Pharmaceuticals, 12 (4), pp.179, 2019, ⟨10.3390/ph12040179⟩
Conference poster hal-02798004v1

SEMISYNTHESIS OF BIOACTIVE C-BENZYLATED DIHYDROCHALCONES FROM RENEWABLE SOURCES

Antonio Cala Peralta , Fabian Mayr , Guillaume Viault , Veronika Temml , Daniela Schuster
RICT 2019 - Interfacing Chemical Biology and Drug Discovery - 55th International Conference on Medicinal Chemistry, Jul 2019, Nantes, France
Conference poster hal-02798163v1

The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional african medicine

Konstantin Neukirch , Antonietta Rossi , Martin Raasch , Simona Pace , Denis Seraphin
67th Annual Conference of the Society for Medicinal Plant and Natural Product Research, Sep 2019, Innsbruck, Austria
Conference poster hal-02864518v1

Computational Investigation of multi-target effects in the arachidonic acid cascade on the example of potent natural 5-LO inhibitor garcinoic acid

Veronika Temml , Helmut Pein , Simona Pace , Ulrike Garscha , Birgit Waltenberger
67th Annual Conference of the Society for Medicinal Plant and Natural Product Research, Sep 2019, Innsbruck, Austria
Conference poster hal-02864513v1

Anti-inflammatory activity of w-oxidized tocotrienols

Chau-Phi Dinh , Alexia Ville , Anaïs Barbe , Thuy Linh To , Guillaume Viault
26th Young Research Fellows Meeting, Feb 2019, Paris, France
Conference poster hal-02796842v1

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

Chau-Phi Dinh , Jean-Jacques Helesbeux , Andreas Koeberle , Daniela Schuster , Oliver Werz
Joint 26th GP2A/ 32nd JFB Conferences, Jun 2018, Asnelles sur Mer, France. MDPI, Pharmaceuticals, 12 (2), pp.73, 2019, ⟨10.3390/ph12020073⟩
Conference poster hal-02796872v1

Garcinia species are potent and selective, allosteric inhibitors of 5-lipoxygenase and provide novel insights into human vitamin E physiology

Andreas Koeberle , Helmut Pein , Simona Pace , Veronika Temml , Ulrike Garscha
Phyto-Valley 1st Austrian Summit on Natural Products, Jan 2018, Seefeld, Austria
Conference poster hal-02864490v1

Semisynthetic pathways towards anti-inflammatory tocotrienols isolated from new-caledonian endemic plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin , Pascal Richomme
14a. RIIPN (14a Reunión Internacional de Productos Naturales), May 2018, Cuernavaca Morelos, Mexico
Conference poster hal-02864440v1

Omega-oxidized terpenoids: from traditional African medicine to novel insights into human vitamin physiology

Helmut Pein , Simona Pace , Veronika Temml , Ulrike Garscha , Birgit Waltenberger
24th Conference on Isoprenoids, Sep 2018, Bialystok, Poland
Conference poster hal-02864499v1

Computational binding mode prediction of ω-oxidized tocotrienols as inhibitors of 5-lipoxygenase

Veronika Temml , Andreas Koeberle , Ulrike Garscha , Jean-Jacques Helesbeux , Birgit Waltenberger
Phyto-Valley 1st Austrian Summit on Natural Products, Jan 2018, Seefeld, Austria
Conference poster hal-02864486v1

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Helmut Pein , Simona Pace , Veronika Temml , Ulrike Garscha , Birgit Waltenberger
7th European Workshop on Lipid Mediators, Sep 2018, Bruxelles, Belgium
Conference poster hal-02864504v1

Semisynthesis of δ-(R)-tocotrienols

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , David Guilet , Pascal Richomme
8ème Symposium Francophone de Synthèse Totale, May 2018, Bordeaux, France
Conference poster hal-02797021v1

Semisynthetic pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New Caledonian endemic plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
Journées des doctorants de la SFR QUASAV, 11ème édition, Oct 2018, Angers, France
Conference poster hal-02864443v1

Computational analysis of the interaction between vitamin E derivatives and 5-lipoxygenase

Veronika Temml , Helmut Pein , Simona Pace , Ulrike Garscha , Birgit Waltenberger
Paracelsus Science Get Together, Jun 2018, Salzbourg, Austria
Conference poster hal-02864497v1

α-amplexichromanol, a vitamin E semisynthetic analog – Valorization of its anti-inflammatory potential

Alexia Ville , Khaled Alsabil , Guillaume Viault , David Guilet , Jean-Jacques Helesbeux
Journée thématique de la SFR ICAT4208, May 2018, Angers, France
Conference poster hal-02864434v1

Synthèse et évaluation biologique de nouveaux actifs potentiels ciblant les dysfonctionnements mitochondriaux

Guillaume Viault , Abdel Benamar , Morgane Le Mao , R. Andriantsitohaina , Jean-Jacques Helesbeux
Journée thématique de la SFR ICAT, May 2018, Angers, France
Conference poster hal-02797199v1

Semi-synthetic derivatives and endogenous metabolites of vitamin E as potent, selective and orally available inhibitors of 5 lipoxygenase

Andreas Koeberle , Helmut Pein , Simona Pace , Veronika Temml , Ulrike Garscha
Frontiers in Medicinal Chemistry, Mar 2018, Iéna, Germany
Conference poster hal-02864495v1

Semisynthetics Pathways Starting from δ-Garcinoic Acid towards Anti-Inflammatory Tocotrienols Isolated from New-Caledonian Endemic Plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩
Conference poster hal-02797913v1

Extraction and Purification of δ-Tocotrienol from Bixa orellana and Semi-Synthesis of 7-Formyl-δ-tocotrienol

Khaled Alsabil , Sorphon Suor-Cherer , H. Y. Lam , Guillaume Viault , Jean-Jacques Helesbeux
25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩
Conference poster hal-02797856v1

δ-Garcinoic Acid, a Convenient Natural Precursor to the Attractive δ-Tocotrienol

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩
Conference poster hal-02797528v1

δ-garcinoic acid, a platform to tocotrienol derivatives isolated from barks of New Caledonian endemics plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
5e journées scientifiques de l’école doctorale VENAM, Nov 2016, Nantes, France
Conference poster hal-02864424v1

mPGES-1 as a New Target for Garcinoic Acid Isoforms

Khaled Alsabil , Sorphon Suor-Cherer , Andreas Koeberle , Guillaume Viault , Daniela Schuster
The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩
Conference poster hal-02797636v1

Synthetic 3-deoxyanthocyanidin analogues of delphinidin as potential vasorelaxant agents

Samuel Legeay , Sébastien Faure , Jean-Jacques Helesbeux , Yannick Abatuci , Olivier Duval
23rd Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2015, Munster, Germany. Pharmaceuticals, 9 (1), pp.1, 2016, ⟨10.3390/ph9010001⟩
Conference poster hal-02864383v1

Semisynthesis of natural formylated tocotrienols

Khaled Alsabil , Jean-Jacques Helesbeux , Denis Seraphin
23rd Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2015, Munster, Germany. Pharmaceuticals, 9 (1), pp.1, 2016, ⟨10.3390/ph9010001⟩
Conference poster hal-02864395v1

Semisynthetic modifications of δ-amplexichromanol, an original tocotrienol with antitumoral properties

Khaled Alsabil , Jean-Jacques Helesbeux , Denis Seraphin
22èmes Conférences Européennes du Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2014, Nantes, France. 2014
Conference poster hal-03247967v1

Lien entre résistance partielle à Alternaria dauci et résistance aux toxines fongiques chez la carotte

Mickaël Lecomte , Latifa Hamama , Linda Voisine , Julia Gatto , Jean-Jacques Helesbeux
10èmes Rencontres de Phytopathologie- Mycologie, 2014, Aussois, France. 2014
Conference poster hal-03281870v1

Studies of the reactivity of 2,3-alkoxynaphtoic acids in the presence of organometallic nucleophiles

Thi Thanh Hà Dao , Jean-Jacques Helesbeux , Anne-Sophie Castanet , Jacques Mortier , Olivier Duval
20èmes Conférences Européennes du Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. 2011
Conference poster hal-03247975v1

New self-assembled monolayers for DIAMS mass spectrometry

Ghislain Tsague Kenfack , Séverine Derbré , Marylène Dias , Suresh Babu , Kamal Elouarzaki
"titre manquant", 2009, Dublin, Ireland. 2009
Conference poster hal-03247633v1
Image document

A new boronate ester-based crosslinking strategy allows the design of nonswelling and long-term stable dynamic covalent hydrogels

N. Lagneau , L. Terriac , P. Tournier , J-J. Helesbeux , Guillaume Viault
Biomaterials Science, 2023, Biomaterials Science, 11 (6), pp.2033-2045. ⟨10.1039/D2BM01690G⟩
Journal articles hal-03991398v1
Image document

Natural Products Targeting the Fungal Unfolded Protein Response as an Alternative Crop Protection Strategy

Thomas Charpentier , Guillaume Viault , Anne-Marie Le Ray , Nelly Bataillé-Simoneau , Jean-Jacques Helesbeux
Journal of Agricultural and Food Chemistry, 2023, 71 (37), pp.13706-13716. ⟨10.1021/acs.jafc.3c03602⟩
Journal articles hal-04208459v1
Image document

Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Christian Kretzer , Paul Jordan , Katharina P.L. Meyer , Daniel Hoff , Markus Werner
Biochemical Pharmacology, 2022, 195, pp.114825. ⟨10.1016/j.bcp.2021.114825⟩
Journal articles hal-03533844v1
Image document

Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3

Gabriele Möller , Veronika Temml , Antonio Cala Peralta , Océane Gruet , Pascal Richomme
Metabolites, 2022, 12 (2), pp.99. ⟨10.3390/metabo12020099⟩
Journal articles hal-03716164v1
Image document

A vitamin E long-chain metabolite and the inspired drug candidate α-amplexichromanol relieve asthma features in an experimental model of allergen sensitization

Ida Cerqua , Konstantin Neukirch , Michela Terlizzi , Elisabetta Granato , Elisabetta Caiazzo
Pharmacological Research, 2022, 181, pp.106250. ⟨10.1016/j.phrs.2022.106250⟩
Journal articles hal-03788166v1
Image document

Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3

Gabriele Möller , Veronika Temml , Antonio Cala Peralta , Océane Gruet , Pascal Richomme
Metabolites, 2022, 12 (2), pp.99. ⟨10.3390/metabo12020099⟩
Journal articles hal-03782968v1
Image document

Role of Phenylpropanoids and Flavonoids in Plant Resistance to Pests and Diseases

Marie-Louisa Ramaroson , Claude Koutouan , Jean-Jacques Helesbeux , Valérie Le Clerc , Latifa Hamama
Molecules, 2022, 27 (23), pp.8371. ⟨10.3390/molecules27238371⟩
Journal articles hal-04053646v1

Photochemical Transformations of Chalcone-Vitamin E Hybrids

Jimmy Josué Ceballos-Cruz , Jean-Jacques Helesbeux , Guillaume Viault , Denis Seraphin , Gumersindo Mirón-López
Journal of the Mexican Chemical Society, 2022, 66 (1), ⟨10.29356/jmcs.v66i1.1670⟩
Journal articles hal-03533848v1

Synthesis of ethylene bis [(2-hydroxy-5,1,3-phenylene) bis methylene] tetraphosphonic acid and their anticorrosive effect on carbon steel in 3%NaCl solution

N. Sait , N. Aliouane , L. Toukal , H. Hammache , M. Al-Noaimi
Journal of Molecular Liquids, 2021, 326, pp.115316. ⟨10.1016/j.molliq.2021.115316⟩
Journal articles hal-03788171v1

Semisynthetic Vitamin E Derivatives as Potent Antibacterial Agents against Resistant Gram‐Positive Pathogens

Guillaume Viault , Marie Kempf , Alexia Ville , Khaled Alsabil , Rodolphe Perrot
ChemMedChem, 2021, 16 (5), pp.881-890. ⟨10.1002/cmdc.202000792⟩
Journal articles hal-03191789v1
Image document

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

Konstantin Neukirch , Khaled Alsabil , Chau-Phi Dinh , Rossella Bilancia , Martin Raasch
Journal of Medicinal Chemistry, 2021, 64 (15), pp.11496-11526. ⟨10.1021/acs.jmedchem.1c00806⟩
Journal articles hal-03783673v1
Image document

Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors

Chau-Phi Dinh , Alexia Ville , Konstantin Neukirch , Guillaume Viault , Veronika Temml
European Journal of Medicinal Chemistry, 2020, 202, pp.112518. ⟨10.1016/j.ejmech.2020.112518⟩
Journal articles hal-02884134v1
Image document

Novel Insights into the Mode of Action of Vasorelaxant Synthetic Polyoxygenated Chalcones

Samuel Legeay , Kien Trân , Yannick Abatuci , Sébastien Faure , Jean-Jacques Helesbeux
International Journal of Molecular Sciences, 2020, 21 (5), pp.1609. ⟨10.3390/ijms21051609⟩
Journal articles hal-02498106v1

Efficient Semi-Synthesis of Natural δ-( R )-Tocotrienols from a Renewable Vegetal Source

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , David Guilet , Pascal Richomme
Journal of Natural Products, 2019, 82 (1), pp.51-58. ⟨10.1021/acs.jnatprod.8b00517⟩
Journal articles hal-02358466v1

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

Helmut Pein , Alexia Ville , Simona Pace , Veronika Temml , Ulrike Garscha
Nature Communications, 2018, 9 (1), pp.3834. ⟨10.1038/s41467-018-06158-5⟩
Journal articles hal-02521285v1
Image document

Aldaulactone – An Original Phytotoxic Secondary Metabolite Involved in the Aggressiveness of Alternaria dauci on Carrot

Julia Courtial , Latifa Hamama , Jean-Jacques Helesbeux , Mickaël Lecomte , Yann Renaud
Frontiers in Plant Science, 2018, 9 (502), pp.502. ⟨10.3389/fpls.2018.00502⟩
Journal articles hal-02061447v1

Concise semisynthesis of novel phenazine-vitamin E hybrids via regioselective tocopheryl ortho-quinone formation

Guillaume Viault , Jean-Jacques Helesbeux , Pascal Richomme , Denis Seraphin
Tetrahedron Letters, 2018, 59 (27), pp.2627-2630. ⟨10.1016/j.tetlet.2018.05.011⟩
Journal articles hal-02521254v1
Image document

Pro-Angiogenic Effects of Low Dose Ethoxidine in a Murine Model of Ischemic Hindlimb: Correlation between Ethoxidine Levels and Increased Activation of the Nitric Oxide Pathway

Nicolas Clere , Kim Hung Thien To , Samuel Legeay , Samuel Bertrand , Jean-Jacques Helesbeux
Molecules, 2017, 22 (4), pp.627. ⟨10.3390/molecules22040627⟩
Journal articles hal-02429803v1

Efficient ortho-formylation in vitamin E series, application to the semi-synthesis of natural 5- and 7-formyl-δ-tocotrienols revealing an unprecedented 5-bromo-7-formyl exchange

Khaled Alsabil , Guillaume Viault , Sorphon Suor-Cherer , Jean-Jacques Helesbeux , Joumaa Merza
Tetrahedron, 2017, 73 (49), pp.6863-6870. ⟨10.1016/j.tet.2017.10.039⟩
Journal articles hal-02521270v1

Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors

Khaled Alsabil , Sorphon Suor-Cherer , Andreas Koeberle , Guillaume Viault , Alexis Lavaud
Planta Medica, 2016, 82 (11/12), pp.1110-1116. ⟨10.1055/s-0042-108739⟩
Journal articles hal-01391940v1

Ethoxyfagaronine, a synthetic analogue of fagaronine that inhibits vascular endothelial growth factor-1, as a new anti-angiogeneic agent

Farid Ouchani , Albin Jeanne , Jessica Thevenard , Jean-Jacques Helesbeux , Amandine Wahart
Investigational New Drugs, 2015, 33 (1), pp.75-85. ⟨10.1007/s10637-014-0184-4⟩
Journal articles hal-01391950v1
Image document

Partial Resistance of Carrot to Alternaria dauci Correlates with In Vitro Cultured Carrot Cell Resistance to Fungal Exudates

Mickaël Lecomte , Latifa Hamama , Linda Voisine , Julia Gatto , Jean-Jacques Helesbeux
PLoS ONE, 2014, 9 (7), pp.e101008. ⟨10.1371/journal.pone.0101008⟩
Journal articles hal-01128311v1

Hydroxamate, a key pharmacophore exhibiting a wide range of biological activities

Samuel Bertrand , Jean-Jacques Helesbeux , Gérald Larcher , Olivier Duval
Mini-Reviews in Medicinal Chemistry, 2013, 13 (9), pp.1311-26. ⟨10.2174/13895575113139990007⟩
Journal articles hal-03333799v1
Image document

Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea

Sylvie Morel , Jean-Jacques Helesbeux , Denis Séraphin , Séverine Derbré , Julia Gatto
Phytochemistry Letters, 2013, 6 (3), pp.498-503. ⟨10.1016/j.phytol.2013.06.002⟩
Journal articles hal-00911058v1

Targeting focal adhesion assembly by ethoxyfagaronine prevents lymphoblastic cell adhesion to fibronectin.

F. Ouchani , J. Devy , A. Rusciani , Helesbeux Jj , S. Salesse
Analytical Cellular Pathology, 2012, 35 (4), pp.267-284
Journal articles hal-00780640v1

Ortho-Lithium/Magnesium Carboxylate-Driven Aromatic Nucleophilic Substitution Reactions on Unprotected Naphthoic Acids

Regadia Aissaoui , Arnaud Nourry , Ariane Coquel , Thi Thanh Hà Dao , Aïcha Derdour
Journal of Organic Chemistry, 2012, 77 (1), pp.718-724. ⟨10.1021/jo202017z⟩
Journal articles hal-00711809v1

Synthesis, crystal structure, and characterization of thiophene-3-carboxaldoxime complexes with cobalt(II), nickel(II) and copper(II) halides

Kusaï Alomar , Jean-Jacques Helesbeux , Magali Allain , Gilles Bouet
Journal of Molecular Structure, 2012, 1019, pp.143 - 150. ⟨10.1016/j.molstruc.2012.02.055⟩
Journal articles hal-03247503v1
Image document

Paradoxical effects of ethoxidine, a topoisomerase I inhibitor, in the cellular processes leading to angiogenesis on endothelial cells

Nicolas Clere , Sébastien Faure , Jean-Jacques Helesbeux , Olivier Duval , Ramaroson Andriantsitohaina
Carcinogenesis, 2011, 32 (3), pp.286-295. ⟨10.1093/carcin/bgq260⟩
Journal articles hal-03247525v1
Image document

Synthesis of New Benzylic Di-, Tri-, and Tetraphosphonic Acids as Potential Chelating Agents

Nabila Aliouane , Jean-Jacques Hélesbeux , Tahar Douadi , Mustayeen A Khan , Gilles Bouet
Phosphorus, Sulfur, and Silicon and the Related Elements, 2011, 186 (2), pp.354-364. ⟨10.1080/10426507.2010.502161⟩
Journal articles hal-03253614v1

Free and immobilized matrix molecules: impairing ionization by quenching secondary ion formation in laser desorption MS

Andreas Schinkovitz , Ghislain Tsague Kenfack , Eric Levillain , Marylène Dias , Jean-Jacques Helesbeux
Journal of Mass Spectrometry, 2011, 46 (9), pp.884 - 890. ⟨10.1002/jms.1965⟩
Journal articles hal-03027839v1

Crystal Structure of Ethoxidine, A Synthetic Quaternary Benzo[c]phenanthridine

Jean-Jacques Helesbeux , Enguerran Vanquelef , Jean Guillon , Jean-Michel Léger , Olivier Duval
Journal of Chemical Crystallography, 2011, 41 (12), pp.1945 - 1948. ⟨10.1007/s10870-011-9986-9⟩
Journal articles hal-03247445v1

The anti-invasive activity of synthetic alkaloid ethoxyfagaronine on L1210 leukemia cells is mediated by down-regulation of plasminogen activators and MT1-MMP expression and activity.

J. Devy , F. Ouchani , C. Oudot , Helesbeux Jj , E. Vanquelef
Investigational New Drugs, 2011, 29, pp.730-741
Journal articles hal-00717331v1

Triazolobithiophene Light Absorbing Self-Assembled Monolayers: Synthesis and Mass Spectrometry Applications

Ghislain Tsague Kenfack , Andreas Schinkovitz , Suresh Babu , Kamal Elouarzaki , Marylène Dias
Molecules, 2011, 16 (12), pp.8758 - 8774. ⟨10.3390/molecules16108758⟩
Journal articles hal-03027827v1
Image document

Novel polydentate phosphonic acids: Protonation and stability constants of complexes with Fe(III) and Cu(II) in aqueous medium

Nabila Aliouane , Salah Chafaa , Tahar Douadi , Jean-Jacques Hélesbeux , Mustayeen A Khan
Heteroatom Chemistry, 2010, 21 (2), pp.51-62. ⟨10.1002/hc.20575⟩
Journal articles hal-03250900v1

Synthesis of the trans-fusarinine scaffold

Samuel Bertrand , Olivier Duval , Jean-Jacques Helesbeux , Gérald Larcher , Pascal Richomme
Tetrahedron Letters, 2010, 51 (16), pp.2119 - 2122. ⟨10.1016/j.tetlet.2010.02.058⟩
Journal articles hal-03247640v1

2H-Pyran-2-one-3-carbothioamide derivatives: Synthesis and reaction with hydrazine hydrate

Malika Makhloufi-Chebli , Maamar Hamdi , Artur Silva , Olivier Duval , Jean-Jacques Helesbeux
Journal of Heterocyclic Chemistry, 2009, 46 (1), pp.18-22. ⟨10.1002/jhet.2⟩
Journal articles hal-03247439v1

A promising method for efficient analysis of secondary metabolites in plant extracts by a matrix-free Desorption/Ionization on self-Assembled Monolayer Surfaces (DIAMS) technique

Suresh Babu , G Tsagueken , Jacqueline Ropivia , Jean-Jacques Helesbeux , Séverine Derbré
Planta Medica, 2009, 75 (9), Non spécifié. ⟨10.1055/s-0029-1234850⟩
Journal articles hal-03027834v1

Synthesis and Antimalarial Activity of Some New 1,2-Dioxolane Derivatives

Jean-Jacques Helesbeux , Damien Peyronnet , Mehdi Labaied , Philippe Grellier , François Frappier
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 17 (6), pp.431-437. ⟨10.1080/1475636021000005677⟩
Journal articles mnhn-02867489v1

Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii

Anne-Emmanuelle Hay , Jean-Jacques Helesbeux , O Duval , Medhi Labaïed , Philippe Grellier
Life Sciences, 2004, 75 (25), pp.3077-3085. ⟨10.1016/j.lfs.2004.07.009⟩
Journal articles mnhn-02070126v1

Molecular docking, semisynthesis and biological evaluations of garcinoic acid amides as 5-lipoxygenase inhibitors

Chau-Phi Dinh , Alexia Ville , Barbe Anaïs , Thuy-Linh To , Konstantin Neukirch
27th Annual GP2A Medicinal Chemistry Conference, Aug 2019, Nottingham, United Kingdom. pp.179, ⟨10.3390/ph12040179⟩
Conference papers hal-02794994v1

Anti-inflammatory activity of vitamin E derivatives

Chau-Phi Dinh , Alexia Ville , Barbe Anaïs , Thuy-Linh To , Konstantin Neukirch
Journée Des Doctorants de l’ED EGAAL, Jul 2019, Rennes, France
Conference papers hal-02795186v1

Structure-based modeling, semisynthesis and biological evaluations of garcinoic acid derivatives

Chau-Phi Dinh , Alexia Ville , Barbe Anaïs , Thuy-Linh To , Konstantin Neukirch
Journée Des Doctorants de la SFR QUASAV, Oct 2019, Angers, France
Conference papers hal-02794835v1

Design, semisynthesis and biological evaluations of garcinoic acid derivatives as novel anti-inflammatory agents

Chau-Phi Dinh , Guillaume Viault , Andreas Koeberle , Hermann Stuppner , Daniela Schuster
25th Young Research Fellows Meeting, Mar 2018, Orléans, France
Conference papers hal-02796904v1

Aldaulactone, a new phytotoxin involved in Alternaria dauci–Daucus carota interaction

Julia Courtial , Latifa Hamama , Jean-Jacques Helesbeux , Mickaël Lecomte , Yann Renaux
11th International Congress of Plant Pathology, 2018, Boston, United States
Conference papers hal-02516643v1

Resistance and pathogenicity: how toxins are involved in the carrot-Alternaria dauci interaction

Julia Courtial , Latifa Hamama , Yann Renaux , Mickaël Lecomte , Esteban Guichard
10ème édition des doctorants de la SFR Quasav, 2017, Angers, France
Conference papers hal-02516577v1

Influence of fungal exudates of Alternaria dauci on carrot partial resistance

Mickaël Lecomte , Latifa Hamama , Linda Voisine , Julia Gatto , Jean-Jacques Helesbeux
International Symposium on Carrot and Other Apiaceae, International Society for Horticultural Science (ISHS). INT., 2017, Angers, France. pp.231-236, ⟨10.17660/ActaHortic.2017.1153.34⟩
Conference papers hal-02516581v1

Towards pharmacologically active tocotrienol derivatives starting from δ-garcinoic acid as a common natural precursor

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
24th Young Research Fellow’s Meeting, Feb 2017, Châtenay-Malabry, France
Conference papers hal-02864430v1

Hémisynthèse d’analogues originaux de la vitamine E à visée anti-inflammatoire

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
Journée des doctorants de la SFR QUASAV, 10e édition, Oct 2017, Angers, France
Conference papers hal-02864455v1

Towards an Alternative to NSAIDs Based on Vitamin E Analogues

Jean-Jacques Helesbeux , Khaled Alsabil , Alexia Ville , Sorphon Suor-Cherer , Guillaume Viault
25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. pp.97, ⟨10.3390/ph10040097⟩
Conference papers hal-02797756v1

Semisynthetic pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New Caledonian endemic plants

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France
Conference papers hal-02864451v1

Hémisynthèse de nouveaux analogues de la vitamine E à visée anti-inflammatoire

Alexia Ville , Guillaume Viault , Jean-Jacques Helesbeux , Denis Seraphin
Séminaire recherche du département Pharmacie, Faculté de Santé, Université d’Angers, Sep 2016, Angers, France
Conference papers hal-02864459v1

Lien entre agressivité et composition des exsudats chez Alternaria dauci, agent causal de la brûlure foliaire de la carotte

Julia Courtial , Latifa Hamama , Yann Renaux , Mickaël Lecomte , Esteban Guichard
11èmes Rencontres Phytopathologie-Mycologie, 2016, Aussois, France
Conference papers hal-02516455v1

Signaling pathways activated after exposure to phytoalexins: an Achilles'heel for necrotrophic fungi?

Philippe Simoneau , Thomas Guillemette , Nelly Bataille-Simoneau , Jean-Jacques Helesbeux , Pascal Richomme
Mission possible: food for all through appropriate plant protection. XVIII International Plant Protection Congress, 2015, Berlin, Germany
Conference papers hal-02516454v1

Paradoxical effects of the topoisomerase inhibitor ethoxidine in the cellular processes leading to angiogenesis on endothelial cells

Nicolas Clere , Sébastien Faure , Jean-Jacques Helesbeux , Olivier Duval , Ramaroson Andriantsitohaina
Printemps de la Cardiologie : Recherche Fondamentale et Clinique, 2010, Nantes, France
Conference papers hal-03247634v1