Jean-Jacques HELESBEUX
87
Documents
Publications
From Phloridzin towards Semisynthetic Bioactive Dihydrochalcones27th Annual GP2A Medicinal Chemistry Conference, Aug 2019, Notthingham, United Kingdom. Pharmaceuticals, 12 (4), pp.179, 2019, ⟨10.3390/ph12040179⟩
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Computational Investigation of multi-target effects in the arachidonic acid cascade on the example of potent natural 5-LO inhibitor garcinoic acid67th Annual Conference of the Society for Medicinal Plant and Natural Product Research, Sep 2019, Innsbruck, Austria
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The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional african medicine67th Annual Conference of the Society for Medicinal Plant and Natural Product Research, Sep 2019, Innsbruck, Austria
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SEMISYNTHESIS OF BIOACTIVE C-BENZYLATED DIHYDROCHALCONES FROM RENEWABLE SOURCESRICT 2019 - Interfacing Chemical Biology and Drug Discovery - 55th International Conference on Medicinal Chemistry, Jul 2019, Nantes, France
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Anti-inflammatory activity of w-oxidized tocotrienols26th Young Research Fellows Meeting, Feb 2019, Paris, France
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Design, semisynthesis and biological evaluations of garcinoic acid derivatives as novel anti-inflammatoryJoint 26th GP2A/ 32nd JFB Conferences, Jun 2018, Asnelles sur Mer, France. Pharmaceuticals, 12 (2), pp.73, 2019, ⟨10.3390/ph12020073⟩
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Computational analysis of the interaction between vitamin E derivatives and 5-lipoxygenaseParacelsus Science Get Together, Jun 2018, Salzbourg, Austria
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Semisynthetic pathways towards anti-inflammatory tocotrienols isolated from new-caledonian endemic plants14a. RIIPN (14a Reunión Internacional de Productos Naturales), May 2018, Cuernavaca Morelos, Mexico
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Omega-oxidized terpenoids: from traditional African medicine to novel insights into human vitamin physiology24th Conference on Isoprenoids, Sep 2018, Bialystok, Poland
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Garcinia species are potent and selective, allosteric inhibitors of 5-lipoxygenase and provide novel insights into human vitamin E physiologyPhyto-Valley 1st Austrian Summit on Natural Products, Jan 2018, Seefeld, Austria
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Semi-synthetic derivatives and endogenous metabolites of vitamin E as potent, selective and orally available inhibitors of 5 lipoxygenaseFrontiers in Medicinal Chemistry, Mar 2018, Iéna, Germany
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Computational binding mode prediction of ω-oxidized tocotrienols as inhibitors of 5-lipoxygenasePhyto-Valley 1st Austrian Summit on Natural Products, Jan 2018, Seefeld, Austria
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Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase7th European Workshop on Lipid Mediators, Sep 2018, Bruxelles, Belgium
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Semisynthetic pathways starting from δ-garcinoic acid towards anti-inflammatory tocotrienols isolated from New Caledonian endemic plantsJournées des doctorants de la SFR QUASAV, 11ème édition, Oct 2018, Angers, France
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Semisynthesis of δ-(R)-tocotrienols8ème Symposium Francophone de Synthèse Totale, May 2018, Bordeaux, France
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Synthèse et évaluation biologique de nouveaux actifs potentiels ciblant les dysfonctionnements mitochondriauxJournée thématique de la SFR ICAT, May 2018, Angers, France
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α-amplexichromanol, a vitamin E semisynthetic analog – Valorization of its anti-inflammatory potentialJournée thématique de la SFR ICAT4208, May 2018, Angers, France
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Semisynthetics Pathways Starting from δ-Garcinoic Acid towards Anti-Inflammatory Tocotrienols Isolated from New-Caledonian Endemic Plants25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩
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Extraction and Purification of δ-Tocotrienol from Bixa orellana and Semi-Synthesis of 7-Formyl-δ-tocotrienol25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 (4), pp.97, 2017, ⟨10.3390/ph10040097⟩
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δ-garcinoic acid, a platform to tocotrienol derivatives isolated from barks of New Caledonian endemics plants5e journées scientifiques de l’école doctorale VENAM, Nov 2016, Nantes, France
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δ-Garcinoic Acid, a Convenient Natural Precursor to the Attractive δ-TocotrienolThe 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩
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mPGES-1 as a New Target for Garcinoic Acid IsoformsThe 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2016, Angers, France. Pharmaceuticals, 10 (1), pp.17, 2017, ⟨10.3390/ph10010017⟩
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Synthetic 3-deoxyanthocyanidin analogues of delphinidin as potential vasorelaxant agents23rd Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2015, Munster, Germany. Pharmaceuticals, 9 (1), pp.1, 2016, ⟨10.3390/ph9010001⟩
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Semisynthesis of natural formylated tocotrienols23rd Conference of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), Aug 2015, Munster, Germany. Pharmaceuticals, 9 (1), pp.1, 2016, ⟨10.3390/ph9010001⟩
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Semisynthetic modifications of δ-amplexichromanol, an original tocotrienol with antitumoral properties22èmes Conférences Européennes du Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2014, Nantes, France. 2014
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Lien entre résistance partielle à Alternaria dauci et résistance aux toxines fongiques chez la carotte10èmes Rencontres de Phytopathologie- Mycologie, 2014, Aussois, France. 2014
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Studies of the reactivity of 2,3-alkoxynaphtoic acids in the presence of organometallic nucleophiles20èmes Conférences Européennes du Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. 2011
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New self-assembled monolayers for DIAMS mass spectrometry"titre manquant", 2009, Dublin, Ireland. 2009
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“The 24th Conference” of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A)2017, pp.17. ⟨10.3390/ph10010017⟩
Other publications
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Potentiating agents for protecting plants from fungal infectionsFrance, Patent n° : US 20200002717 A1 20200102. 2020
Patents
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Preparation of tocotrienol derivatives, pharmaceutical composition and method of use in 5-lipoxygenase related diseasesFrance, Patent n° : WO 2017032881 A1 20170302. 2017
Patents
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Potentiating agents for protecting plants from fungal infectionsFrance, Patent n° : US 20150216174 A1 20150806. 2015
Patents
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29th Annual GP2A Medicinal Chemistry ConferencePharmaceuticals, 14 (12), pp.1278, 2021, ⟨10.3390/ph14121278⟩
Special issue
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29th Annual GP2A Medicinal Chemistry ConferencePharmaceuticals, 14 (12), pp.1278, 2021, ⟨10.3390/ph14121278⟩
Proceedings
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