Juliette Vergnaud

Professeure des Universités, Institut Galien Paris-Saclay, Université Paris-Saclay (Faculté de Pharmacie)
48
Documents
Affiliations actuelles
  • Institut Galien Paris-Saclay (IGPS)
  • Université Paris-Saclay
Contact

Présentation

Juliette Vergnaud est Professeure des Universités à la faculté de Pharmacie de l'Université Paris-Saclay. Elle effectue ses recherches au sein de l'Institut Galien Paris-Saclay.


Compétences

Biologie cellulaire Biochimie métabolique pharmacotechnie

Publications

Publications

Deposit thumbnail

Inhibition of TRAP1 in the C-terminal domain influences mitochondria properties and breast cancer cell metabolism

Clélia Mathieu , Jessica Ristow Branco , Patricia Zancan , Catherine Brenner , Samir Messaoudi et al.

Biomedicine and Pharmacotherapy, 2026, 196, pp.119060. ⟨10.1016/j.biopha.2026.119060⟩

Article dans une revue hal-05524058v1
Deposit thumbnail

Deciphering the role of polyethylene glycol-lipid anchors in siRNA-LNP efficacy for P2y2 inhibition in bone marrow-derived macrophages

Sezen Gül , Juliette Vergnaud , Qinglin Wang , Mélanie Hery , Jhon Mino et al.

International Journal of Pharmaceutics, 2025, 684, pp.126186. ⟨10.1016/j.ijpharm.2025.126186⟩

Article dans une revue hal-05322517v1
Deposit thumbnail

Robust micelles formulation to improve systemic corticosteroid therapy in sepsis in multiple healthcare systems

Younes Louaguenouni , Qinglin Wang , Thomas Baticle , Catherine Cailleau , Elodie Lamy et al.

Journal of Controlled Release, 2025, 381, pp.113635. ⟨10.1016/j.jconrel.2025.113635⟩

Article dans une revue hal-05029253v1
Deposit thumbnail

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Qinglin Wang , Jihana Achour , Laila Emam , Younes Louaguenouni , Catherine Cailleau et al.

Advanced Healthcare Materials, 2025, 14 (29), pp.e00695. ⟨10.1002/adhm.202500695⟩

Article dans une revue hal-05237521v1
Deposit thumbnail

Precision engineering of macrophage reprogramming with RNA interference-loaded lipid nanoparticles: a game-changer in cancer immunotherapy

Sezen Gül , Juliette Vergnaud , François Fay , Elias Fattal

Drug Delivery and Translational Research, In press, ⟨10.1007/s13346-025-01970-1⟩

Article dans une revue hal-05272960v1
Deposit thumbnail

Next Generation of Porphysomes for Improved Photodynamic Therapy Applications

Jana Alhoussein , Khatia Merabishvili , Tiffany Ho , Abdechakour Elkihel , Paul Cressey et al.

Journal of Controlled Release, 2025, 381, pp.113621. ⟨10.1016/j.jconrel.2025.113621⟩

Article dans une revue hal-05432004v1
Deposit thumbnail

Contribution of chain length of proximal enzymes-targeted polymers to inhibitory effect on three-dimensional multicellular tumor spheroids

Yuki Koba , Masahiko Nakamoto , Séverine Domenichini , Juliette Vergnaud , Mélanie Hery et al.

MRS Communications, 2025, 15 (6), pp.1097-1104. ⟨10.1557/s43579-025-00779-w⟩

Article dans une revue hal-05452619v1
Deposit thumbnail

Pd‐Catalyzed Coupling of Bromo‐N‐(β‐glucopyranosyl)quinolin‐2‐ones with Amides: Synthesis of N‐glucosyl‐6BrCaQ Conjugates with Potent Anticancer Activity

Wafa Redjdal , Sara Benmahdjoub , Thi Thanh Hyen Luong , Belkacem Benmerad , Franck Le Bideau et al.

ChemMedChem, 2024, 19 (15), pp.e202400195. ⟨10.1002/cmdc.202400195⟩

Article dans une revue hal-04905231v1

Controlled hydrogel-based encapsulation of macrophages determines cell survival and functionality upon cryopreservation

Natalia Ortiz Silva , Stéphanie Denis , Juliette Vergnaud , Hervé Hillaireau

International Journal of Pharmaceutics, 2024, 650, pp.123491. ⟨10.1016/j.ijpharm.2023.123491⟩

Article dans une revue hal-04359989v1
Deposit thumbnail

Overcoming Solubility Challenges: Liposomal isoCoQ‐Carbazole as a Promising Anti‐Tumor Agent for Inoperable and Radiation‐Insensitive cancers

Diana Lamaa , Catherine Cailleau , Juliette Vergnaud , Julie Mougin , Jérôme Bignon et al.

ChemBioChem, 2024, 25 (10), pp.e202400062. ⟨10.1002/cbic.202400062⟩

Article dans une revue hal-04569859v1
Deposit thumbnail

Amphiphilic phosphorus dendrons-associated with anti-inflammatory siRNA reduce symptoms in murine collagen-induced arthritis

Zhibo Yu , Nicolas Tsapis , François Fay , Liang Chen , Andrii Karpus et al.

Biomacromolecules, 2023, 24 (2), pp.667-677. ⟨10.1021/acs.biomac.2c01117⟩

Article dans une revue hal-04101289v1
Deposit thumbnail

Mannosylation Of Budesonide Palmitate Nanoprodrugs For Improved Macrophage Targeting

Ludmila Pinheiro Do Nascimento , Nicolas Tsapis , Franceline Reynaud , Didier Desmaële , Laurence Moine et al.

European Journal of Pharmaceutics and Biopharmaceutics, 2022, 170, pp.112-120. ⟨10.1016/j.ejpb.2021.12.001⟩

Article dans une revue hal-03475936v1
Deposit thumbnail

Synthesis and antiproliferative activity of 6BrCaQ-TPP conjugates for targeting the mitochondrial heat shock protein TRAP1

Clelia Mathieu , Quentin Chamayou , Thi Thanh Hyen Luong , Delphine Naud , Florence Mahuteau-Betzer et al.

European Journal of Medicinal Chemistry, 2022, 229, pp.114052. ⟨10.1016/j.ejmech.2021.114052⟩

Article dans une revue hal-03795373v1
Deposit thumbnail

Synthesis and Biological Activity of 3-(Heteroaryl)quinolin-2(1H)-ones Bis-Heterocycles as Potential Inhibitors of the Protein Folding Machinery Hsp90

Enrique Larghi , Alexandre Bruneau , Félix Sauvage , Mouad Alami , Juliette Vergnaud-Gauduchon et al.

Molecules, 2022, 27 (2), pp.412. ⟨10.3390/molecules27020412⟩

Article dans une revue hal-03855550v1
Deposit thumbnail

Combining dexamethasone and TNF-α siRNA within the same nanoparticles to enhance anti-inflammatory effect

Serra Gürcan , Nicolas Tsapis , Franceline Reynaud , Stéphanie Denis , Juliette Vergnaud et al.

International Journal of Pharmaceutics, 2021, 598, pp.120381. ⟨10.1016/j.ijpharm.2021.120381⟩

Article dans une revue hal-03215959v1

Development of purified glycogen derivatives as siRNA nanovectors

Giuseppe Francesco Racaniello , Valentino Laquintana , Juliette Vergnaud , Angela Lopedota , Annalisa Cutrignelli et al.

International Journal of Pharmaceutics, 2021, 608, pp.121128. ⟨10.1016/j.ijpharm.2021.121128⟩

Article dans une revue hal-04247560v1

Nanotoxicology at the particle/micelle frontier: influence of core-polymerization on the intracellular distribution, cytotoxicity and genotoxicity of polydiacetylene micelles

Federica Costamagna , Hervé Hillaireau , Juliette Vergnaud-Gauduchon , Damien Clarisse , Lucie Jamgotchian et al.

Nanoscale, 2020, 12 (4), pp.2452-2463. ⟨10.1039/C9NR08714A⟩

Article dans une revue hal-02430885v1
Deposit thumbnail

Assessment of various formulation approaches for the application of beta-lapachone in prostate cancer therapy

Xiao Wu , Athena Kasselouri , Juliette Vergnaud-Gauduchon , Véronique Rosilio

International Journal of Pharmaceutics, 2020, 579, pp.119168. ⟨10.1016/j.ijpharm.2020.119168⟩

Article dans une revue hal-03489806v1

Mannose distribution in glycoconjugated tetraphenylporphyrins governs their uptake mechanism and phototoxicity

Katia Daghildjian , Athena Kasselouri , Marline N’diaye , Jean-Philippe Michel , Juliette Vergnaud et al.

Journal of Porphyrins and Phthalocyanines, 2019, 23 (01n02), pp.175-184. ⟨10.1142/S1088424619500184⟩

Article dans une revue hal-04269464v1
Deposit thumbnail

Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines

Félix Sauvage , François-Xavier Legrand , Michel Roux , Ivan Rajkovic , Thomas M. Weiss et al.

Journal of Colloid and Interface Science, 2019, 537, pp.704--715. ⟨10.1016/j.jcis.2018.11.059⟩

Article dans une revue hal-02183686v1

Hybrid Lipid Polymer Nanoparticles for Combined Chemo- and Photodynamic Therapy

Marline N’diaye , Juliette Vergnaud-Gauduchon , Valérie Nicolas , Victor Faure , Stéphanie Denis et al.

Molecular Pharmaceutics, 2019, 16 (9), pp.4045-4058. ⟨10.1021/acs.molpharmaceut.9b00797⟩

Article dans une revue hal-04269472v1
Deposit thumbnail

Cancer drug resistance: rationale for drug delivery systems and targeted inhibition of HSP90 family proteins

Clélia Mathieu , Samir Messaoudi , Elias Fattal , Juliette Vergnaud-Gauduchon

Cancer Drug Resistance, 2019, ⟨10.20517/cdr.2019.26⟩

Article dans une revue hal-02396633v1

Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice

Félix Sauvage , Elias Fattal , Walhan Al-Shaer , Stéphanie Denis , Emilie Brotin et al.

Cancer Letters, 2018, 432, pp.103-111. ⟨10.1016/j.canlet.2018.06.001⟩

Article dans une revue istex inserm-02096216v1

Aptamer-guided siRNA-loaded nanomedicines for systemic gene silencing in CD-44 expressing murine triple-negative breast cancer model

Walhan Alshaer , Hervé Hillaireau , Juliette Vergnaud , Simona Mura , Félix Sauvage et al.

Journal of Controlled Release, 2018, 271, pp.98-106. ⟨10.1016/j.jconrel.2017.12.022⟩

Article dans une revue hal-04252728v1

Formulation and in vitro efficacy of liposomes containing the Hsp90 inhibitor 6BrCaQ in prostate cancer cells

Félix Sauvage , Silvia Franzè , Alexandre Bruneau , Mouad Alami , Stéphanie Denis et al.

International Journal of Pharmaceutics, 2016, 499 (1-2), pp.101-109. ⟨10.1016/j.ijpharm.2015.12.053⟩

Article dans une revue istex hal-04354282v1

Surface-Modified Biodegradable Nanoparticles' Impact on Cytotoxicity and Inflammation Response on a Co-Culture of Lung Epithelial Cells and Human-Like Macrophages

Nadège Grabowski , Hervé Hillaireau , Juliette Vergnaud-Gauduchon , Valérie Nicolas , Nicolas Tsapis et al.

Journal of Biomedical Nanotechnology, 2016, 12 (1), pp.135-146. ⟨10.1166/jbn.2016.2126⟩

Article dans une revue hal-04722601v1
Deposit thumbnail

Formulation and Pharmacokinetics of Thermosensitive Stealth® Liposomes Encapsulating 5-Fluorouracil

Chantal Al Sabbagh , Nicolas Tsapis , Anthony Novell , Patricia Calleja-Gonzalez , Jean-Michel Escoffre et al.

Pharmaceutical Research, 2015, 32 (5), pp.1585-1603. ⟨10.1007/s11095-014-1559-0⟩

Article dans une revue inserm-02438401v1

Surface coating mediates the toxicity of polymeric nanoparticles towards human-like macrophages

Nadège Grabowski , Hervé Hillaireau , Juliette Vergnaud , Nicolas Tsapis , Marc Pallardy et al.

International Journal of Pharmaceutics, 2015, 482 (1-2), pp.75-83. ⟨10.1016/j.ijpharm.2014.11.042⟩

Article dans une revue istex hal-04736817v1

Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial

Jeremie Talvas , G. Garrait , Nicolas Goncalves-Mendez , J. Rouanet , Juliette Vergnaud-Gauduchon et al.

Clinical Nutrition, 2015, 34 (5), pp.810-817. ⟨10.1016/j.clnu.2014.12.002⟩

Article dans une revue istex hal-01214151v1

Epigallocatechin Gallate (EGCG) Prevents H2O2-Induced Oxidative Stress in Primary Rat Retinal Pigment Epithelial Cells

David Cia , Juliette Vergnaud-Gauduchon , Nathalie Jacquemot , Michel Doly

Current Eye Research, 2014, 39 (9), pp.944-952. ⟨10.3109/02713683.2014.885532⟩

Article dans une revue hal-02638847v1

Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans

Olivier Perche , Juliette Vergnaud-Gauduchon , Christine Morand , Claude Dubray , André Mazur et al.

Clinical Nutrition, 2014, 33 (1), pp.130-135. ⟨10.1016/j.clnu.2013.03.012⟩

Article dans une revue istex hal-02639414v1

Toxicity of surface-modified PLGA nanoparticles toward lung alveolar epithelial cells

Nadège Grabowski , Hervé Hillaireau , Juliette Vergnaud , Letícia Aragão Santiago , Saadia Kerdine-Römer et al.

International Journal of Pharmaceutics, 2013, 454 (2), pp.686-694. ⟨10.1016/j.ijpharm.2013.05.025⟩

Article dans une revue istex hal-04738841v1

Altered functions of natural killer cells in response to L-Arginine availability

Bruno Lamas , Juliette Vergnaud-Gauduchon , Nicolas Goncalves-Mendes , Olivier Perche , Adrien Rossary et al.

Cellular Immunology, 2012, 280 (2), pp.182-190. ⟨10.1016/j.cellimm.2012.11.018⟩

Article dans une revue istex hal-02651580v1

Altered functions of natural killer cells in response to L-Arginine availability

Bruno Lamas , Juliette Vergnaud-Gauduchon , Nicolas Goncalves-Mendès , Olivier Perche , Adrien Rossary et al.

Cellular Immunology, 2012, 280 (2), pp.182-190. ⟨10.1016/j.cellimm.2012.11.018⟩

Article dans une revue istex hal-04645048v1

Lemon Verbena Infusion Consumption Attenuates Oxidative Stress in Dextran Sulfate Sodium-Induced Colitis in the Rat

Loïc Lenoir , Adrien Rossary , Juliette Joubert-Zakeyh , Juliette Vergnaud-Gauduchon , Marie-Chantal Farges et al.

Digestive Diseases and Sciences, 2011, 56 (12), pp.3534-3545. ⟨10.1007/s10620-011-1784-x⟩

Article dans une revue istex hal-03176066v1
Deposit thumbnail

Liposomal trichostatin A: therapeutic potential in hormone-dependent and -independent breast cancer xenograft models

Giorgia Urbinati , Véronique Marsaud , Valérie Nicolas , Juliette Vergnaud-Gauduchon , Jack-Michel Renoir

Hormone Molecular Biology and Clinical Investigation, 2011, 6 (2), pp.215-25. ⟨10.1515/HMBCI.2011.005⟩

Article dans une revue istex hal-02330041v1
Deposit thumbnail

Improved antitumoral properties of pure antiestrogen RU 58668-loaded liposomes in multiple myeloma

Sébastien Maillard , Juliette Gauduchon , Véronique Marsaud , Fabrice Gouilleux , Elisabeth Connault et al.

Journal of Steroid Biochemistry and Molecular Biology, 2006, 100 (1-3), pp.67-78. ⟨10.1016/j.jsbmb.2006.03.008⟩

Article dans une revue hal-02424614v1

Innovative drug delivery nanosystems improve the anti-tumor activity in vitro and in vivo of anti-estrogens in human breast cancer and multiple myeloma

Sébastien Maillard , Thibault Ameller , Juliette Gauduchon , Angélique Gougelet , Fabrice Gouilleux et al.

Journal of Steroid Biochemistry and Molecular Biology, 2005, 94 (1-3), pp.111-121. ⟨10.1016/j.jsbmb.2004.12.023⟩

Article dans une revue inserm-02532838v1

Innovative drug delivery nanosystems improve the anti-tumor activity in vitro and in vivo of anti-estrogens in human breast cancer and multiple myeloma.

Sébastien Maillard , Thibault Ameller , Juliette Gauduchon , Angélique Gougelet , Fabrice Gouilleux et al.

Journal of Steroid Biochemistry and Molecular Biology, 2005, 94 (1-3), pp.111-21. ⟨10.1016/j.jsbmb.2004.12.023⟩

Article dans une revue hal-00389005v1
Deposit thumbnail

Innovative drug delivery nanosystems improve the anti-tumor activity in vitro and in vivo of anti-estrogens in human breast cancer and multiple myeloma

Sébastien Maillard , Thibault Ameller , Juliette Gauduchon , Angélique Gougelet , Fabrice Gouilleux et al.

Journal of Steroid Biochemistry and Molecular Biology, 2005, 94 (1-3), pp.111-121. ⟨10.1016/j.jsbmb.2004.12.023⟩

Article dans une revue hal-03411311v1
Deposit thumbnail

4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members

Juliette Gauduchon , Fabrice Gouilleux , Sébastien Maillard , Véronique Marsaud , Jack-Michel Renoir et al.

Clinical Cancer Research, 2005, 11 (6), pp.2345-2354. ⟨10.1158/1078-0432.CCR-04-1668⟩

Article dans une revue hal-02427343v1
Deposit thumbnail

The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines

Juliette Gauduchon , Fabrice Gouilleux , Sébastien Maillard , Véronique Marsaud , Michel Renoir et al.

Annals of the New York Academy of Sciences, 2003, 1010 (1), pp.321-325. ⟨10.1196/annals.1299.057⟩

Article dans une revue hal-02427345v1

NK cell functional adaptation to L-Arg availability: in vitro approaches

Bruno Lamas , Marie-Chantal Farges , Stéphanie Rouge , Nicolas Goncalves-Mendes , Adrien Rossary et al.

7. Asia Pacific Conference on Clinical Nutrition, Jun 2011, Bangkok, Thailand

Communication dans un congrès hal-02805884v1

La disponibilité en arginine module la fonctionnalité des cellules NK : approches in vitro à partir de la lignée NK-92 et de NK humaines isolées

Bruno Lamas , Juliette Vergnaud-Gauduchon , Nicolas Goncalves-Mendes , Adrien Rossary , Marie-Paule Vasson et al.

Journée des Doctorants de l’Unité de Nutrition Humaine, May 2011, Clermont-Ferrand, France

Communication dans un congrès hal-02805695v1

Does L-Arginine availability modulates NK cell functions ? In vitro approaches

Bruno Lamas , Juliette Vergnaud-Gauduchon , Nicolas Goncalves-Mendes , Stéphanie Rouge , Marie-Paule Vasson et al.

Clinical Nutrition Week, Feb 2010, Las Vegas, United States

Communication dans un congrès hal-02817690v1

In vitro L-arginine deprivation impairs natural killer cell functions

Bruno Lamas , Juliette Vergnaud-Gauduchon , Stéphanie Rouge , Marie-Paule Vasson , Marie-Chantal Farges

32nd European Society of Parenteral and Enteral Nutrition Congress, Sep 2010, Nice, France

Communication dans un congrès hal-02817684v1

Activité cytolytique des cellules Natural Killer humaines en réponse à une déplétion en arginine

Bruno Lamas , Juliette Vergnaud-Gauduchon , Olivier Perche , Stéphanie Rouge , Marie-Chantal Farges et al.

Journée de la Recherche Sciences de la Vie et de la Santé, Oct 2009, Clermont-Ferrand, France

Communication dans un congrès hal-02817691v1

Effet in vitro de l’arginine sur la prolifération, la survie et la cytotoxicité de la lignée cellulaire NK-92

Bruno Lamas , Juliette Vergnaud-Gauduchon , Olivier Perche , Nicolas Goncalves-Mendes , Stéphanie Rouge et al.

Journée Scientifique du CRNH Auvergne, Dec 2008, Clermont-Ferrand, France

Communication dans un congrès hal-02817693v1