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laurent elkaim

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Passerini–Smiles Reaction of α‐Ketophosphonates: Platform for Phospha‐Brook/Smiles Embedded Cascades

Cristina Cheibas , Nicolas Fincias , Nicolas Casaretto , Julian Garrec , Laurent El Kaïm et al.
Angewandte Chemie International Edition, 2022, 61 (11), ⟨10.1002/anie.202116249⟩
Journal articles hal-03763413v1
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Synthesis of 2-phosphonoheterocycles via base-promoted 5-endo cyclization

Ameni Bousbia , Mohamed Lamine Benkhoud , Laurent El Kaim , Sébastien Prévost
Tetrahedron Letters, 2021, 64, pp.152742. ⟨10.1016/j.tetlet.2020.152742⟩
Journal articles hal-03307256v1

A Passerini/Tsuji-Trost access to dienamide derivatives

Sihem Dali Youcef , Mansour Dolé Kerim , Hocine Ilitki , Laurent El Kaim
Tetrahedron Letters, 2019, 60 (2), pp.102-105. ⟨10.1016/j.tetlet.2018.11.068⟩
Journal articles hal-02096732v1

A Ugi Straightforward Access to Bis-β-lactam Derivatives

Cristina Cheibas , Marie Cordier , Yanyan Li , Laurent El Kaim
European Journal of Organic Chemistry, 2019, 2019 (27), pp.4457-4463. ⟨10.1002/ejoc.201900678⟩
Journal articles hal-02280748v1

Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts

Alaa Zidan , Abeer El-Naggar , Nour Abd El-Sattar , Ali Khalil Ali , Laurent El Kaim et al.
Frontiers in Chemistry, 2019, 7 (20), ⟨10.3389/fchem.2019.00020⟩
Journal articles hal-02096847v1

A Passerini/Michael Pathway towards Butyrolactones

Shuanglong Jia , Laurent El Kaim
European Journal of Organic Chemistry, 2018, 2018 (46), pp.6457-6464. ⟨10.1002/ejoc.201800958⟩
Journal articles hal-02095101v1

TiCl4-Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions

Sudipta Ponra , Aude Nyadanu , Sylvie Maurin , Laurent El Kaim , Laurence Grimaud et al.
Synthesis: Journal of Synthetic Organic Chemistry, 2018, 50 (06), pp.1331-1342. ⟨10.1055/s-0036-1591733⟩
Journal articles hal-02095068v1

Propargylation of Ugi Amide Dianion: An Entry into Pyrrolidinone and Benzoindolizidine Alkaloid Analogues

Alaa Zidan , Marie Cordier , Abeer El-Naggar , Nour Abd El-Sattar , Mohamed Ali Hassan et al.
Organic Letters, 2018, 20 (9), pp.2568-2571. ⟨10.1021/acs.orglett.8b00687⟩
Journal articles hal-02094200v1

Mannich reaction of trifluoroacetaldehyde hydrazones

Shuanglong Jia , Laurent El Kaim
Organic & Biomolecular Chemistry, 2018, 16 (9), pp.1457-1460. ⟨10.1039/c7ob02840g⟩
Journal articles hal-02095052v1

Metal-free Deamidative Ugi Access to Isoindolinones

Samira Baaziz , Mansour Dole Kerim , Marie Cordier , Lamouri Hammal , Laurent El Kaim et al.
SYNLETT, 2018, 29 (14), pp.1842-1846. ⟨10.1055/s-0037-1610189⟩
Journal articles hal-01999460v1

Palladium-catalysed O -Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles

Mansour Dolé Kerim , Martin Cattoen , Nicolas Fincias , Aurélie Dos santos , Stellios Arseniyadis et al.
Advanced Synthesis and Catalysis, 2018, 360 (3), pp.449-454. ⟨10.1002/adsc.201701150⟩
Journal articles hal-02091718v1

Palladium triggered diene formation from nitro allylic compounds: a versatile entry into naphthalene derivatives

Mansour Dolé Kerim , Shuanglong Jia , Chrysoula Theodorakidou , Sébastien Prevost , Laurent El Kaim et al.
Chemical Communications, 2018, 54 (77), pp.10917-10920. ⟨10.1039/c8cc06536e⟩
Journal articles hal-02094211v1
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From Benzofurans to Indoles: Palladium-Catalyzed Reductive Ring-Opening and Closure via β-Phenoxide Elimination

Luca Alessandro Perego , Simon Wagschal , Raymond Grüber , Paul Fleurat-Lessard , Laurent El Kaim et al.
Advanced Synthesis and Catalysis, 2018, 361 (1), pp.151-159. ⟨10.1002/adsc.201801225⟩
Journal articles hal-01913160v1

4-Aminopyrimidine libraries from the Ugi-Smiles reaction of thiouracil

Madjid Ait Sidhoum , Laurent El Kaim , Laurence Grimaud
Tetrahedron, 2018, 74 (38), pp.5222-5231. ⟨10.1016/j.tet.2018.04.058⟩
Journal articles hal-02096394v1

Passerini/Tsuji-Trost Strategy towards Pyrrole Derivatives

Noisette Narboni , Laurent El Kaim
European Journal of Organic Chemistry, 2017, 2017 (29), pp.4242-4246. ⟨10.1002/ejoc.201700653⟩
Journal articles hal-02094146v1

β-Lactam Synthesis through Diodomethane Addition to Amide Dianions

Laurent El Kaim , Aurélie dos Santos , Marie Cordier , Alaa Zidan , Julian Garrec et al.
Angewandte Chemie International Edition, 2017, 56 (40), pp.12179 - 12183. ⟨10.1002/anie.201706315⟩
Journal articles hal-01664662v1

Ugi–Smiles Couplings of Purine Derivatives

Laurent El Kaim , Abdelbari Abdessalem , Raoudha Abderrahim , Aurélie dos Santos , Laurence Grimaud et al.
SYNLETT, 2017, 28 (06), pp.691 - 694. ⟨10.1055/s-0036-1588117⟩
Journal articles hal-01664666v1

Nef–Perkow–Mumm Cascade towards Imido Phosphate Derivatives

Laurent El Kaim , Aurélie dos Santos , Marie Cordier
SYNLETT, 2017, 28 (19), pp.2637 - 2641. ⟨10.1055/s-0036-1590856⟩
Journal articles hal-01664663v1

Nef-Perkow cascade towards imidazo phosphate derivatives

Somayeh Ghorbani , Ebrahim Soleimani , Laurent El Kaim
Tetrahedron Letters, 2017, 58 (49), pp.4595-4597. ⟨10.1016/j.tetlet.2017.10.055⟩
Journal articles hal-02096435v1
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N–N bond formation in Ugi processes: from nitric acid to libraries of nitramines

Valentina Mercalli , Aude Nyadanu , Marie Cordier , Gian Cesare Tron , Laurence Grimaud et al.
Chemical Communications, 2017, 53 (13), pp.2118 - 2121. ⟨10.1039/C6CC10288C⟩
Journal articles hal-01472845v1
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Optimized Conditions for Passerini-Smiles Reactions and Applications to Benzoxazinone Syntheses

Elodie Martinand-Lurin , Aurélie dos Santos , Emmanuelle Robineau , Pascal Retailleau , Philippe Dauban et al.
Molecules, 2016, 21 (9), pp.1257. ⟨10.3390/molecules21091257⟩
Journal articles hal-01373389v1

Piperazine as Leaving Group in A3 Adducts: Fast Access to Alkynyl Indoles

Mansour Dole Kerim , Laurent El Kaim
SYNLETT, 2016, 27 (10), pp.1572-1576 ⟨10.1055/s-0035-1561396⟩
Journal articles hal-01444342v1

Multiple Roles of Isocyanides in Palladium-Catalyzed Imidoylative Couplings: A Mechanistic Study

Luca A. Perego , Paul Fleurat-Lessard , Laurent El Kaim , Ilaria Ciofini , Laurence Grimaud et al.
Chemistry - A European Journal, 2016, 22 (43), pp.15491 - 15500. ⟨10.1002/chem.201602913⟩
Journal articles hal-01400558v1

Passerini/Friedel–Crafts Route towards Indole Derivatives

Laurent El Kaim , El El Mamouni , Aurélie dos Santos , Hocine Ilitki
SYNLETT, 2016, 27 (18), pp.2571 - 2574. ⟨10.1055/s-0035-1561497⟩
Journal articles hal-01664674v1

Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles

Elhachemia Elmamouni , M. Cattoen , Marie Cordier , Janine Cossy , Stellios Arseniyadis et al.
Chemical Communications, 2016, 52 (100), pp.14490-14493 ⟨10.1039/c6cc08171a⟩
Journal articles hal-01623194v1

TiCl4-Mediated Preparation of Thiophthalide Derivatives via Formal Thio-Passerini Reactions

Sudipta Ponra, , Aude Nyadanu, , Laurent El Kaim , Laurence Grimaud , Maxime R. Vitale et al.
Organic Letters, 2016, 18 (16), pp.4060-4063. ⟨10.1021/acs.orglett.6b01937⟩
Journal articles hal-01456154v1

The Ugi Reaction of Cyanoacetic Acid as a Route to Tetramic Acid Derivatives

Nancy Alvarez-Rodríguez , Aurélie dos Santos , Laurent El Kaim , Rocío Gámez-Montaño
SYNLETT, 2015, 26 (16), ⟨10.1055/s-0035-1560050⟩
Journal articles hal-01217812v1

Passerini/Tsuji-Trost strategies towards achieving lactams and cyclopentane derivatives.

Marie Cordier , Aurélie dos Santos , Laurent El Kaim , Noisette Narboni
Chemical Communications, 2015, 51 (29), pp.6411-4. ⟨10.1039/C5CC00584A⟩
Journal articles hal-01152233v1

A Nonoxidative Passerini Pathway to α-Ketoamides

Abdelbari Ben Abdessalem , Raoudha Abderrahim , Laurent El Kaim
SYNLETT, 2015, 26 (18), pp.2537-2540. ⟨10.1055/s-0035-1560632⟩
Journal articles hal-01245816v1

Synthesis, antimicrobial and antioxidant activities of imidazotriazoles and new multicomponent reaction toward 5-amino-1-phenyl[1,2,4]triazole derivatives

Monia Aouali , Dhekra Mhalla , Fatma Allouche , Laurent El Kaim , Slim Tounsi et al.
Medicinal Chemistry Research, 2015, 24 (6), pp.2732-2741. ⟨10.1007/s00044-015-1322-z⟩
Journal articles hal-01186609v1

Correction: Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines

Abdelbari Ben Abdessalem , Raoudha Abderrahim , Asma Agrebie , Aurélie dos Santos , Laurent El Kaim et al.
Chemical Communications, 2015, 51 (97), ⟨10.1039/c5cc90512e⟩
Journal articles hal-01276153v1

Reductive Passerini/Tsuji-Trost Strategy towards beta,gamma-Unsaturated Amides

Aurélie dos Santos , Laurent El Kaim
SYNLETT, 2014, 25 (13), pp.1901-1903. ⟨10.1055/s-0033-1340187⟩
Journal articles hal-01065732v1

Nitrile Synthesis through Catalyzed Cascades Involving Acid-Nitrile Exchange

Damien Cartigny , Aurélie dos Santos , Laurent El Kaim , Laurence Grimaud , Roland Jacquot et al.
Synthesis: Journal of Synthetic Organic Chemistry, 2014, 46 (13), pp.1802-1806. ⟨10.1055/s-0033-1341227⟩
Journal articles hal-01044733v1

The Ugi-Smiles and Passerini-Smiles Couplings: A Story About Phenols in Isocyanide-Based Multicomponent Reactions

Laurent El Kaim , Laurence Grimaud
European Journal of Inorganic Chemistry, 2014, 2014 (35), ⟨10.1002/ejoc.201402783⟩
Journal articles hal-01217971v1

Kinetic Data on the Synergetic Role of Amines and Water in the Reduction of Phosphine-Ligated Palladium(II) to Palladium(0)

Christian Amatore , Laurent El Kaim , Laurence Grimaud , Anny Jutand , Alice Meignié et al.
European Journal of Organic Chemistry, 2014, 22 (august), pp.4709-4713. ⟨10.1002/ejoc.201402519⟩
Journal articles hal-01057787v1

Double Smiles rearrangement of Passerini adducts towards benzoxazinones.

E. Martinand-Lurin , A. dos Santos , Laurent El Kaim , L. Grimaud , P. Retailleau et al.
Chemical Communications, 2014, 50 (17), pp.2214-7. ⟨10.1039/c3cc49022j⟩
Journal articles hal-00958815v1

Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines

Abdelbari Ben Abdessalem , Raoudha Abderrahim , Asma Agrebie , Aurélie dos Santos , Laurent El Kaim et al.
Chemical Communications, 2014, 51 (6), pp.1116-1119. ⟨10.1039/C4CC08282F⟩
Journal articles hal-01114416v1

Benzoxazinone synthesis via Passerini-Smiles couplings

E. Martinand-Lurin , Laurent El Kaim , L. Grimaud
Tetrahedron Letters, 2014, 55 (37), pp.5144-5146. ⟨10.1016/j.tetlet.2014.07.088⟩
Journal articles hal-01075102v1

Predicting New Ugi-Smiles Couplings: A Combined Experimental and Theoretical Study

Romain Ramozzi , Nicolas Chéron , Laurent El Kaim , Laurence Grimaud , Paul Fleurat-Lessard et al.
Chemistry - A European Journal, 2014, 20 (29), pp.9094-9099. ⟨10.1002/chem.201400336⟩
Journal articles hal-01057795v1

The Nef Reaction of Isocyanides

Fabio La Spisa , Gian Cesare Tron , Laurent El Kaim
Synthesis: Journal of Synthetic Organic Chemistry, 2014, 46 (7), pp.829-841. ⟨10.1055/s-0033-1338596⟩
Journal articles hal-01015399v1

Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters

Naïm Ait Sidhoum , Aurélie dos Santos , Laurent El Kaim , Laetitia Legras
European Journal of Organic Chemistry, 2014, 2014 (23), pp.4949-4952. ⟨10.1002/ejoc.201402572⟩
Journal articles hal-01065722v1

Cyclization Cascade of Hydrazono Ugi Adducts towards Pyrazoles

Laurent El Kaim , Asma Agrebi , Fatma Allouche , Fakher Chabchoub
European Journal of Organic Chemistry, 2013, 2013 (26), pp.5805 - 5808. ⟨10.1002/ejoc.201300787⟩
Journal articles hal-01664698v1

Substituent Effects in Ugi–Smiles Reactions

Nicolas Chéron , Romain Ramozzi , Laurent El Kaim , Laurence Grimaud , Paul Fleurat-Lessard et al.
Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases, 2013, 117 (33), pp.8035-8042. ⟨10.1021/jp4052227⟩
Journal articles hal-01116243v1

Metal-free aerobic oxidation of benzazole derivatives

Aurelie dos Santos , Laurent El Kaim , Laurence Grimaud
Organic & Biomolecular Chemistry, 2013, 11 (20), pp.3282-3287. ⟨10.1039/c3ob27404g⟩
Journal articles hal-00949977v1

Sc(OTf)3 promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine

Asma Agrebi , Fatma Allouche , Fakher Chabchoub , Laurent El Kaim , Sérgio Alves et al.
Tetrahedron Letters, 2013, 54 (35), pp.4781 - 4784. ⟨10.1016/j.tetlet.2013.06.136⟩
Journal articles hal-01664696v1

Lewis Acid Mediated Fragmentation of Tetrazoles towards Triazoles

Laurent El Kaim , Laurence Grimaud , Patil Pravin
European Journal of Organic Chemistry, 2013, 2013 (22), pp.4752 - 4755. ⟨10.1002/ejoc.201300620⟩
Journal articles hal-01664716v1

Synthesis of 2-Tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a One-Pot Ugi-Azide/Pictet–Spengler Process

Laurent El Kaim , Luis Cárdenas-Galindo , Alejandro Islas-Jácome , Nancy Alvarez-Rodríguez , Rocío Gámez-Montaño et al.
Synthesis: Journal of Synthetic Organic Chemistry, 2013, 46 (01), pp.49 - 56. ⟨10.1055/s-0033-1340051⟩
Journal articles hal-01664692v1

Pyrrolo[2,3-d]pyrimidine synthesis through activation of N-benzyl groups by distal amides

Laurent El Kaim , Laurence Grimaud , Simon Wagschal
Organic & Biomolecular Chemistry, 2013, 11 (40), ⟨10.1039/C3OB41477A⟩
Journal articles hal-01664695v1

Three-Component Metal-Free Arylation of Isocyanides

Laurent El Kaim , Unnamatla Basavanag , Aurélie Dos santos , Rocio Gámez-Montaño , Laurence Grimaud et al.
Angewandte Chemie International Edition, 2013, 52 (28), pp.7194 - 7197. ⟨10.1002/anie.201302659⟩
Journal articles hal-01664717v1

Palladium-catalyzed ring opening of aminocyclopropyl Ugi adducts

Aurélie dos Santos , Laurent El Kaim , Laurence Grimaud , Romain Ramozzi
SYNLETT, 2012, 3, pp.438-442. ⟨10.1055/s-0031-1290312⟩
Journal articles hal-00949987v1

Four-Component Synthesis of Indazole through Ugi-Azide Coupling

Laurent El Kaim , Laurence Grimaud , Srinivas Purumandla
SYNLETT, 2012, 2012 (02), pp.295 - 297. ⟨10.1055/s-0031-1290075⟩
Journal articles hal-01664772v1

Challenging 50 Years of Established Views on Ugi Reaction: A Theoretical Approach

Nicolas Chéron , Romain Ramozzi , Laurent El Kaim , Laurence Grimaud , Paul Fleurat-Lessard et al.
Journal of Organic Chemistry, 2012, 77 (3), pp.1361-1366. ⟨10.1021/jo2021554⟩
Journal articles hal-01116252v1

Oxazole Synthesis from Isocyanides

Laurent El Kaim , Laurence Grimaud , Pravin Patil
SYNLETT, 2012, 23 (9), pp.1361-1363. ⟨10.1055/s-0031-1290939⟩
Journal articles hal-00949986v1

Ugi-Smiles Coupling of Thiouracil Derivatives towards 2,4-Diamino Pyrimidines

Madjid Sidhoum , Laurent El Kaim , Laurence Grimaud
SYNLETT, 2012, 23 (04), pp.632 - 636. ⟨10.1055/s-0031-1290347⟩
Journal articles hal-01664771v1

Ugi-Smiles couplings of 4-substituted pyridine derivatives: A fast access to chloroquine analogues

Laurent El Kaim , Laurence Grimaud , Patil Pravin
Organic Letters, 2012, 14 (2), pp.476-478. ⟨10.1021/ol202974w⟩
Journal articles hal-00949992v1

Palladium catalyzed ring opening of furans as a route to α,β-unsaturated aldehydes

Laurent El Kaim , Laurence Grimaud , Simon Wagschal
Chemical Communications, 2011, 47 (6), pp.1887 - 1889. ⟨10.1039/C0CC04164E⟩
Journal articles hal-01664788v1

Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols

Laurent El Kaim , Laurence Grimaud , Srinivas Reddy Purumandla
European Journal of Organic Chemistry, 2011, - (31), pp.6177-6180. ⟨10.1002/ejoc.201100939⟩
Journal articles hal-00951232v1

Smiles Cascades toward Heterocyclic Scaffolds

Laurent El Kaim , Laurence Grimaud , X. F Le Goff , Aurelie Schiltz
Organic Letters, 2011, pp.534-536
Journal articles hal-00695039v1

Copper-catalyzed aerobic oxidative cyclization of hydrazones to pyrazolidinones

Aurélie dos Santos , Laurent El Kaim , Laurence Grimaud , Caroline Ronsseray
European Journal of Organic Chemistry, 2011, 2011 (17), pp.3117-3121. ⟨10.1002/ejoc.201100261⟩
Journal articles hal-00950011v1

Multicomponent synthesis of fused benzimidazolopiperazines

Laurent El Kaim , Laurence Grimaud , Srinivas Reddy Purumandla
Journal of Organic Chemistry, 2011, 76 (11), pp.4728-4733. ⟨10.1021/jo200397m⟩
Journal articles hal-00951229v1

Xanthate Based Radical Cascade Toward Multicomponent Formation of Pyrrolopyrimidines

Laurent El Kaim , Laurence Grimaud , Patil Pravin
Molecules, 2011, 16 (12), pp.9261 - 9273. ⟨10.3390/molecules16119261⟩
Journal articles hal-01664773v1

Allyl and Benzyl Dance under Basic Conditions

Laurent El Kaim , Laurence Grimaud , Srinivas Reddy Purumandla , Srinivas Purumandla
SYNLETT, 2011, 2011 (13), pp.1816 - 1820. ⟨10.1055/s-0030-1260964⟩
Journal articles hal-01664781v1

Evidences for the Key Role of Hydrogen Bonds in Nucleophilic Aromatic Substitution Reactions

Nicolas Chéron , Laurent El Kaim , Laurence Grimaud , Paul Fleurat-Lessard
Chemistry - A European Journal, 2011, 17 (52), pp.14929-14934. ⟨10.1002/chem.201102463⟩
Journal articles hal-01116254v1
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Xanthate based radical cascade toward multicomponent formation of pyrrolopyrimidines

Laurent El Kaim , Laurence Grimaud , Patil Pravin
Molecules, 2011, 16 (11), pp.9261-9273. ⟨10.3390/molecules16119261⟩
Journal articles hal-00951237v1
Image document

Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles

Aurélie dos Santos , Laurent El Kaim , Laurence Grimaud , Caroline Ronsseray
Beilstein Journal of Organic Chemistry, 2011, 7, pp.1310-1314. ⟨10.3762/bjoc.7.153⟩
Journal articles hal-00951236v1

A Density Functional Theory Study of the Nef-Isocyanide Reaction: Mechanism, Influence of Parameters and Scope

Nicolas Chéron , Laurent El Kaim , Laurence Grimaud , Paul Fleurat-Lessard
Journal of Physical Chemistry A, 2011, 115 (35), pp.10106 - 10112. ⟨10.1021/jp205909d⟩
Journal articles hal-01664774v1

Three-Component Strategy toward 5-Membered Heterocycles from Isocyanide Dibromides.

Laurent El Kaim , Laurence Grimaud , Pravin Patil
Organic Letters, 2011, 13 (5), pp.1261 - 1263. ⟨10.1021/ol200003u⟩
Journal articles hal-01664777v1

A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines

Aurélie dos Santos , Laurence Grimaud , Caroline Ronsseray , Didier Coffinier , Laurent El Kaim et al.
Tetrahedron Letters, 2011, 52 (23), pp.3023 - 3025. ⟨10.1016/j.tetlet.2011.04.007⟩
Journal articles hal-01664785v1

Straightforward four-component access to spiroindolines

Laurent El Kaim , Laurence Grimaud , X. F Le Goff , M. Menes-Arzate , Ld Miranda et al.
Chemical Communications, 2011, pp.8145-8147
Journal articles hal-00695235v1

Four-Component Synthesis of Imidazolinium-Fused Heterocycles from Ugi-Smiles Couplings (pub)

Anaelle Barthelon , X. F Le Goff , Laurent El Kaim , Laurence Grimaud
SYNLETT, 2010, 1, pp.153-157
Journal articles hal-00577187v1

Three-Component Nef-Huisgen Access to 1,2,4-Triazoles

Laurent El Kaim , Laurence Grimaud , Simon Wagschal
SYNLETT, 2009, 2009 (08), pp.1315 - 1317. ⟨10.1055/s-0028-1216738⟩
Journal articles hal-01671035v1

Three-component Ugi–Smiles couplings of cyclic imines

Laurent El Kaim , Laurent El Kaïm , Laurence Grimaud , Julie Oble , Simon Wagschal et al.
Tetrahedron Letters, 2009, 50 (15), pp.1741 - 1743. ⟨10.1016/j.tetlet.2009.01.145⟩
Journal articles hal-01671038v1

Isocyanide-Based Two-Step Three-Component Keteneimine Formation

Laurent El Kaim , Didier Coffinier , Laurence Grimaud
Organic Letters, 2009, 11 (8), pp.1825 - 1827. ⟨10.1021/ol9004432⟩
Journal articles hal-01671032v1

One-pot synthesis of oxazoles using isocyanide surrogates

Laurent El Kaim , Laurent El Kaim , Laurence Grimaud , Aurelie Schiltz
Tetrahedron Letters, 2009, 50 (37), pp.5235 - 5237. ⟨10.1016/j.tetlet.2009.07.001⟩
Journal articles hal-01671029v1

Isocyanide-Based Multicomponent Reaction ‘without’ Isocyanides

Laurent El Kaim , Laurence Grimaud , Aurelie Schiltz
SYNLETT, 2009, 2009 (09), pp.1401 - 1404. ⟨10.1055/s-0029-1217184⟩
Journal articles hal-01671034v1

Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium species

Laurent El Kaim , Laurence Grimaud
Tetrahedron, 2009, 65 (11), pp.2153 - 2171. ⟨10.1016/j.tet.2008.12.002⟩
Journal articles hal-01671037v1

“Isocyanide-free” Ugi reactions

Laurent El Kaim , Laurence Grimaud , Aurelie Schiltz
Organic & Biomolecular Chemistry, 2009, 7 (15), ⟨10.1039/B908541F⟩
Journal articles hal-01671030v1

Unconventional oxazole formation from isocyanides

Laurent El Kaim , Aurélie dos Santos , Laurence Grimaud , Caroline Ronsseray
Chemical Communications, 2009, 26, ⟨10.1039/b904699b⟩
Journal articles hal-01671031v1

New Benzotriazole and Benzimidazole Scaffolds from Ugi−Smiles Couplings of Isocyanides

Laurent El Kaim , Didier Coffinier , Laurence Grimaud
Organic Letters, 2009, 11 (4), pp.995 - 997. ⟨10.1021/ol8029438⟩
Journal articles hal-01671039v1

New palladium-catalyzed aerobic oxidative cleavage and cyclization of N-aryl peptide derivatives

Laurent El Kaim , Rocio Gamez-Montaño , Laurence Grimaud , Tannya Ibarra-Rivera
Chemical Communications, 2008, 11, ⟨10.1039/B716849G⟩
Journal articles hal-01671048v1

Isocyanide Addition to Acylphosphonates: A Formal Passerini Reaction of Acyl Chlorides

Laurent El Kaim , Didier Coffinier , Laurence Grimaud
SYNLETT, 2008, 2008 (8), pp.1133 - 1136. ⟨10.1055/s-2008-1072726⟩
Journal articles hal-01671047v1

Thiols in Ugi- and Passerini-Smiles-Type Couplings

Laurent El Kaim , Anaelle Barthelon , Marie Gizolme , Laurence Grimaud
European Journal of Organic Chemistry, 2008, 2008 (35), pp.5974 - 5987. ⟨10.1002/ejoc.200800859⟩
Journal articles hal-01671040v1

Ugi/Smiles access to pyrazine scaffolds

Laurent El Kaim , Anaelle Barthelon , Aurélie Dos Santos , Laurent El Kaïm , Laurence Grimaud et al.
Tetrahedron Letters, 2008, 49 (20), pp.3208 - 3211. ⟨10.1016/j.tetlet.2008.03.100⟩
Journal articles hal-01671046v1

New MCR−Heck−Isomerization Cascade toward Indoles

Laurent El Kaim , Marion Gizzi , Laurence Grimaud
Organic Letters, 2008, 10 (16), pp.3417 - 3419. ⟨10.1021/ol801217a⟩
Journal articles hal-01671043v1

Smiles rearrangement in Ugi and Passerini type couplings: new multicomponent accesses to O- and N-arylamides

Laurent El Kaim , Marie Gizolme , Laurence Grimaud , Julie Oble
Journal of Organic Chemistry, 2007, 72, pp.4169
Journal articles hal-00176917v1

Ugi-Smiles access to quinoxalines derivatives.

Julie Oble , Laurent El Kaim , Marion Gizzi , Laurence Grimaud
Heterocycles, 2007, pp.667
Journal articles hal-00176915v1

New indolizines template from the Ugi reaction.

Laurent El Kaim , Marie Gizolme , Laurence Grimaud
SYNLETT, 2007, pp.227
Journal articles hal-00176920v1

New benzothiazole and benzoxazole scaffolds from the Ugi–Smiles couplings of heterocyclic thiols

Laurent El Kaim , Marie Gizolme , Laurence Grimaud , Julie Oble
SYNLETT, 2007, pp.465
Journal articles hal-00176918v1

From simple Ugi adducts to indanes and amidomalonates: new manganese (III) induced radical cascades

Laurent El Kaim , Laurence Grimaud , Emilie Vieu
Organic Letters, 2007, 9, Asap
Journal articles hal-00176934v1

New Ugi-Smiles-metathesis strategy towards the synthesis of pyrimido azepines.

Laurent El Kaim , Marie Gizolme , Laurence Grimaud , Julie Oble
Journal of Organic Chemistry, 2007, 72, pp.5835
Journal articles hal-00176916v1

New Ugi/Pictet–Spengler multicomponent formation of polycyclic diketopiperazines from isocyanides and a-keto acids

M. Gageat , L. Gaultier , Laurent El Kaim , Laurence Grimaud
SYNLETT, 2007, pp.500
Journal articles hal-00176919v1

Solvent free preparation of amidophosphonates from isocyanides

S. Hadrot , Laurent El Kaim , Laurence Grimaud
Tetrahedron Letters, 2006, 47, pp.3945
Journal articles hal-00176925v1

Direct access to heterocyclic scaffolds by new multicomponent Ugi Smiles coupling

Laurent El Kaim , Marie Gizolme , Laurence Grimaud , Julie Oble
Organic Letters, 2006, 8, pp.4019
Journal articles hal-00176922v1

New ortho-quinone methide formation: application to three-component coupling of isocyanides, aldehydes and phenols

Laurent El Kaim , Laurence Grimaud , Julie Oble
Organic & Biomolecular Chemistry, 2006, 4, pp.3410
Journal articles hal-00176924v1

O-Arylative Passerini reaction

Laurent El Kaim , Marie Gizolme , Laurence Grimaud
Organic Letters, 2006, 8, pp.5021
Journal articles hal-00176923v1

Ugi /xanthate cyclisations as a radical route to lactam scaffolds

Emilie Vieu , Luis D. Miranda , Laurent El Kaim , Laurence Grimaud
Tetrahedron Letters, 2006, 47, pp.8259
Journal articles hal-00176921v1

Dramatic effect of boron-based Lewis acid in cross-metathesis reactions

H. Dupont , S. Oualef , Laurent El Kaim , Laurence Grimaud , E. Vedrenne et al.
SYNLETT, 2005, pp.670
Journal articles hal-00176929v1

Formation of new phosphates from aldehydes by a DBU-catalysed Phospha-Brook rearrangement in a polar solvent

Aurélie dos Santos , Laurent El Kaim , L. Gaultier , Laurence Grimaud
SYNLETT, 2005, pp.2335
Journal articles hal-00176928v1

Phenol-Ugi-Smiles Systems: Highly efficient strategies for the multicomponent N-arylation of primary amines with isocyanides, aldehydes and phenols

Laurent El Kaim , Laurence Grimaud , Julie Oble
Angewandte Chemie, 2005, 44, pp.7165
Journal articles hal-00176926v1

Towards the Synthesis of Paulitin: New Insights into the Enyne-Metathesis Mechanism

F. Royer , E. Vedrenne , Laurent El Kaim , Laurence Grimaud , Julie Oble et al.
SYNLETT, 2005, pp.2379
Journal articles hal-00176927v1

First carbamates conversion to amides by simple alkyl group transfer from trialkylalanes

A. Lee , Y. Perroux , C. Tirla , Laurent El Kaim , Laurence Grimaud et al.
Organic Letters, 2004, 6, pp.381
Journal articles hal-00176932v1

From isocyanides to trichloropyruvamides : Application to new preparation of Oxamide derivatives

Laurent El Kaim , L. Gaultier , Laurence Grimaud , Emilie Vieu
Tetrahedron Letters, 2004, 45, pp.8047
Journal articles hal-00176931v1

New straightforward quinoline synthesis from the Mannich reaction of ketohydrazones

V. Michaut , V. Baillez , Laurent El Kaim
Synthetic Communications, 2004, 34, pp.109
Journal articles hal-00176933v1

New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides

T. Colin , L. Gatay , Laurent El Kaim , L. Gaultier , Laurence Grimaud et al.
Tetrahedron Letters, 2004, 45, pp.5611
Journal articles hal-00176930v1