Ling PENG

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Publications

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P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis

Jing Ma , Sally Kit Yan To , Katie Sze Wai Fung , Kun Wang , Jiangwen Zhang et al.
Cell Reports, 2025, 44 (1), pp.115096. ⟨10.1016/j.celrep.2024.115096⟩
Article dans une revue hal-04881848 v1
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Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group

Alessia Cavazza , Francisco J Molina-Estévez , Álvaro Plaza Reyes , Victor Ronco , Asma Naseem et al.
Molecular Therapy - Nucleic Acids, 2025, 36 (1), pp.102457. ⟨10.1016/j.omtn.2025.102457⟩
Article dans une revue hal-04931602 v1
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STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy

Miao Zhang , Yongling Wang , Benhao Li , Bowei Yang , Mengyao Zhao et al.
Advanced Materials, In press, ⟨10.1002/adma.202412654⟩
Article dans une revue hal-04931603 v1
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Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis

Zeyu Shi , Margarita Artemenko , Weiyu Yu , Ming Zhang , Canhui Yi et al.
ACS Applied Materials & Interfaces, 2025, ⟨10.1021/acsami.4c12857⟩
Article dans une revue hal-04868442 v1
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Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate

Nian Zhang , Dinesh Dhumal , Shanny Hsuan Kuo , Shi Qian Lew , Pankaj Patil et al.
Science Advances , 2024, 10 (39), pp.eadn8117. ⟨10.1126/sciadv.adn8117⟩
Article dans une revue hal-04710306 v1
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Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors

Zhenbin Lyu , Brigino Ralahy , Teodora-Adriana Perles-Barbacaru , Ling Ding , Yifan Jiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (25), pp.e2322403121. ⟨10.1073/pnas.2322403121⟩
Article dans une revue hal-04610233 v1
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Capture and flocculation of toxic cyanobacteria by amphiphilic peptide dendrimers for mitigating harmful blooms

Heng Zheng , Pier-Luc Tremblay , Wang Chen , Qi Wang , Danni Hu et al.
Chemical Engineering Journal, 2024, ⟨10.1016/j.cej.2024.151382⟩
Article dans une revue hal-04550900 v1
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Development of an efficient NUPR1 inhibitor with anticancer activity

Xi Liu , Ana Jimenez-Alesanco , Zexian Li , Bruno Rizzuti , José L Neira et al.
Scientific Reports, 2024, 14 (1), pp.29515. ⟨10.1038/s41598-024-79340-z⟩
Article dans une revue hal-04813298 v1

The synergistic neurovascular electro-healing of infected diabetic wounds by a multifaceted absorbable ion-conductive adhesive patch

Wenlong Wei , Jiayi Zheng , Ziru Liu , Ziqiu Li , Xiangyu Chen et al.
Chemical Engineering Journal, 2024, 500, pp.156387. ⟨10.1016/j.cej.2024.156387⟩
Article dans une revue hal-04749088 v1
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Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases

Noah King , Dinesh Dhumal , Shi Qian Lew , Shanny Hsuan Kuo , Christina Galanakou et al.
ACS Infectious Diseases, 2024, 10 (2), pp.453-466. ⟨10.1021/acsinfecdis.3c00425⟩
Article dans une revue hal-04465187 v1
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Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy

Tom Roussel , Daniel Ferry , Artemis Kosta , Dalila Miele , Giuseppina Sandri et al.
ACS Materials Au, 2024
Article dans une revue hal-04622011 v2
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Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study

Tom Roussel , Twiany Cruz-Dubois , Beatrice Louis , Erik Laurini , Ling Ding et al.
Journal of materials chemistry‎ B, In press, ⟨10.1039/D4TB01266F⟩
Article dans une revue hal-04851748 v1
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Cargo-selective and adaptive delivery of nucleic acid therapeutics by bola-amphiphilic dendrimers

Jiaxuan Chen , Dandan Zhu , Baoping Lian , Kangjie Shi , Peng Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (21), pp.e2220787120. ⟨10.1073/pnas.2220787120⟩
Article dans une revue hal-04099741 v1
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A PD‐L1 Antibody‐Conjugated PAMAM Dendrimer Nanosystem for Simultaneously Inhibiting Glycolysis and Promoting Immune Response in Fighting Breast Cancer

Peng Zhang , Zhi Li , Weiling Cao , Jingjie Tang , Yi Xia et al.
Advanced Materials, In press, ⟨10.1002/adma.202305215⟩
Article dans une revue hal-04193228 v1
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Modular Self‐Assembling Dendrimer Nanosystems for Magnetic Resonance And Multimodality Imaging of Tumors

Ling Ding , Zhenbin Lyu , Teodora‐adriana Perles-Barbacaru , Adela Ya‐ting Huang , Baoping Lian et al.
Advanced Materials, 2023, ⟨10.1002/adma.202308262⟩
Article dans une revue hal-04315766 v2
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Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?

Christina Galanakou , Dinesh Dhumal , Ling Peng
Biomaterials Science, In press, ⟨10.1039/D2BM01878K⟩
Article dans une revue hal-04009305 v1
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Progress and Harmonization of Gene Editing to Treat Human Diseases (Proceeding of COST Action CA21113 GenE-HumDi)

Alessia Cavazza , Ayal Hendel , Rasmus O Bak , Paula Rio , Marc Güell et al.
Molecular Therapy - Nucleic Acids, 2023, ⟨10.1016/j.omtn.2023.102066⟩
Article dans une revue hal-04283508 v1
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Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking

Yifan Jiang , Zhenbin Lyu , Brigino Ralahy , Juan Liu , Tom Roussel et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, ⟨10.1073/pnas.2215308120⟩
Article dans une revue hal-03977439 v1
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Amphiphilic Dendrimer Doping Enhanced pH-Sensitivity of Liposomal Vesicle for Effective Co-delivery Toward Synergistic Ferroptosis-Apoptosis Therapy of Hepatocellular Carcinoma

Yanhong Su , Zhao Zhang , Leo Tsz , Ling Peng , Ligong Lu et al.
Advanced Healthcare Materials, 2023, 12 (6), pp.2202663. ⟨10.1002/adhm.202202663⟩
Article dans une revue hal-03940472 v1
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Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Yunfang Xiong , Ran Ke , Qingyu Zhang , Wenjun Lan , Wanjun Yuan et al.
Advanced Science, 2022, pp.2200562. ⟨10.1002/advs.202200562⟩
Article dans une revue hal-03701082 v1

A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery

Chi Ma , Dandan Zhu , Wenyi Lin , Ying Li , Yuanzheng Huang et al.
Chemical Communications, 2022, ⟨10.1039/D1CC06655B⟩
Article dans une revue hal-03536584 v1
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Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Wenzheng Zhang , Dinesh Dhumal , Xiaolei Zhu , Brigino Ralahy , Aleksandra Ellert-Miklaszewska et al.
Chemistry - A European Journal, In press, ⟨10.1002/chem.202201400⟩
Article dans une revue hal-03725167 v1

Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

Bo Hu , Bo Li , Kun Li , Yuanyuan Liu , Chunhui Li et al.
Science Advances , 2022, 8 (7), ⟨10.1126/sciadv.abm1418⟩
Article dans une revue hal-03590890 v1

NUPR1 protects against hyperPARylation-dependent cell death

Patricia Santofimia-Castano , Can Huang , Xi Liu , Yi Xia , Stephane Audebert et al.
Communications Biology, 2022, 5 (1), ⟨10.1038/s42003-022-03705-1⟩
Article dans une revue hal-04084989 v1
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Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction

Ya-Ting Huang , C.-L Kao , A Selvaraj , Ling Peng
Materials Today Chemistry, 2022, ⟨10.1016/j.mtchem.2022.101285⟩
Article dans une revue (article de synthèse) hal-03878638 v1
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Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms

Dinesh Dhumal , Bar Maron , Einav Malach , Zhenbin Lyu , Ling Ding et al.
Nanoscale, 2022, ⟨10.1039/d2nr02305a⟩
Article dans une revue hal-03691397 v1
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Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective

Jiaxuan Chen , Dandan Zhu , Xiaoxuan Liu , Ling Peng
Accounts of Materials Research, 2022, ⟨10.1021/accountsmr.1c00272⟩
Article dans une revue hal-03674633 v1
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An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Dinesh Dhumal , Wenjun Lan , Ling Ding , Yifan Jiang , Zhenbin Lyu et al.
Nano Research, 2021, ⟨10.1007/s12274-020-3216-8⟩
Article dans une revue hal-03041310 v1

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

Can Huang , Patricia Santofimia-Castaño , Xi Liu , Yi Xia , Ling Peng et al.
Cell Death Discovery, 2021, 7 (1), pp.269. ⟨10.1038/s41420-021-00662-2⟩
Article dans une revue hal-03536613 v1
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Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

Bruno Rizzuti , Wenjun Lan , Patricia Santofimia-Castaño , Zhengwei Zhou , Adrián Velázquez-Campoy et al.
Biomolecules, 2021, 11 (10), pp.1453. ⟨10.3390/biom11101453⟩
Article dans une revue hal-03536609 v1

Dendrimeric Nanosystem Consistently Circumvents Heterogeneous Drug Response and Resistance in Pancreatic Cancer

Juan Liu , Chao Chen , Tuo Wei , Odile Gayet , Céline Loncle et al.
Energy Exploration and Exploitation, 2021, 1 (1), pp.21-34. ⟨10.1002/EXP.20210003⟩
Article dans une revue hal-03361161 v1
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A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine

Mei Cong , Guangling Xu , Shaoyou Yang , Jing Zhang , Wenzheng Zhang et al.
Chinese Chemical Letters, 2021, ⟨10.1016/j.cclet.2021.11.083⟩
Article dans une revue hal-03536604 v1
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Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen , Aleksandra Ellert-Miklaszewska , Stefano Garofalo , Arindam K Dey , Jingjie Tang et al.
Nature Protocols, 2021, ⟨10.1038/s41596-020-00418-9⟩
Article dans une revue hal-03041303 v1
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Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Stefano Garofalo , Germana Cocozza , Alessandra Porzia , Maurizio Inghilleri , Marcello Raspa et al.
Nature Communications, 2020, 11 (1), pp.1773. ⟨10.1038/s41467-020-15644-8⟩
Article dans une revue hal-02551996 v1
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Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

Kai-Wen Huang , Vikash Reebye , Katherine Czysz , Simona Ciriello , Stephanie Dorman et al.
Molecular Therapy - Nucleic Acids, 2020, 19, pp.361 - 370. ⟨10.1016/j.omtn.2019.10.044⟩
Article dans une revue hal-02992731 v1
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Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma

Wenjun Lan , Patricia Santofimia-Castaño , Yi Xia , Zhengwei Zhou , Can Huang et al.
Cancer Letters, 2020, 486, pp.8-17. ⟨10.1016/j.canlet.2020.04.024⟩
Article dans une revue hal-02994552 v1
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Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates

Yanhua Zhang , Yun Lin , Qianqian Hou , Xi Liu , Sabrina Pricl et al.
Organic & Biomolecular Chemistry, 2020, ⟨10.1039/d0ob02164d⟩
Article dans une revue hal-03041312 v1
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Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study

Ling Ding , Zhenbin Lyu , Beatrice Louis , Aura Tintaru , Erik Laurini et al.
Small, 2020, 16, pp.301-304. ⟨10.1002/smll.202003290⟩
Article dans une revue hal-02992689 v1
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Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

Yanhua Zhang , Xi Liu , Yun Lin , Baoping Lian , Wenjun Lan et al.
Chemical Communications, 2020, 56 (69), pp.10014-10017. ⟨10.1039/d0cc04660d⟩
Article dans une revue hal-02992738 v1
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Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amidoamine) dendrimers

Zhenbin Lyu , Ling Ding , Aura Tintaru , Ling Peng
Accounts of Chemical Research, 2020, ⟨10.1021/acs.accounts.0c00589⟩
Article dans une revue hal-03041818 v1

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Ling Ding , Zhenbin Lyu , Aura Tintaru , Erik Laurini , Domenico Marson et al.
Chemical Communications, 2020, 56 (2), pp.301-304. ⟨10.1039/c9cc07750b⟩
Article dans une revue hal-02480314 v1
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Therapeutic siRNA: state of the art

Bo Hu , Liping Zhong , Yuhua Weng , Ling Peng , Yuanyu Huang et al.
Signal Transduction and Targeted Therapy, 2020, 5 (1), ⟨10.1038/s41392-020-0207-x⟩
Article dans une revue hal-02992725 v1
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ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Wenjun Lan , Patricia Santofimia-Castaño , Mirna Swayden , Yi Xia , Zhengwei Zhou et al.
JCI Insight, 2020, 5 (18), pp.e138117. ⟨10.1172/jci.insight.138117⟩
Article dans une revue hal-03877804 v1
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Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector

Aleksandra Ellert-Miklaszewska , Natalia Ochocka , Marta Maleszewska , Ling Ding , Erik Laurini et al.
Nanomedicine, 2019, 14 (18), pp.2441 - 2458. ⟨10.2217/nnm-2019-0176⟩
Article dans une revue hal-02992806 v1
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Poly(amidoamine) dendrimers: covalent and supramolecular synthesis

Z. Lyu , L. Ding , A.Y.T. Huang , L. Kao , Ling Peng
Materials Today Chemistry, 2019, 13, pp.34-48. ⟨10.1016/j.mtchem.2019.04.004⟩
Article dans une revue hal-02140381 v1

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

Patricia Santofimia-Castaño , Bruno Rizzuti , Yi Xia , Olga Abián , Ling Peng et al.
Molecular & Cellular Oncology, 2019, pp.1-3. ⟨10.1080/23723556.2019.1612678⟩
Article dans une revue hal-02140372 v1
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Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Zhengwei Zhou , Biyao Luo , Xi Liu , Mimi Chen , Wenjun Lan et al.
Chemical Communications, 2019, 55 (61), pp.8919 - 8922. ⟨10.1039/c9cc04084f⟩
Article dans une revue hal-02992833 v1
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Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Patricia Santofimia-Castaño , Yi Xia , Wenjun Lan , Zhengwei Zhou , Can Huang et al.
Journal of Clinical Investigation, 2019, 129 (6), pp.2500 - 2513. ⟨10.1172/jci127223⟩
Article dans une revue hal-02992816 v1

Targeting intrinsically disordered proteins involved in cancer

Patricia Santofimia-Castaño , Bruno Rizzuti , Yi Xia , Olga Abián , Ling Peng et al.
Cellular and Molecular Life Sciences, 2019, ⟨10.1007/s00018-019-03347-3⟩
Article dans une revue hal-02491357 v1
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Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

Patricia Santofimia-Castaño , Yi Xia , Ling Peng , Adrián Velázquez-Campoy , Olga Abián et al.
Cells, 2019, 8 (11), pp.1453. ⟨10.3390/cells8111453⟩
Article dans une revue (article de synthèse) hal-02480322 v1
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Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria

Cheng-Cai Zhang , Cong-Zhao Zhou , Robert L Burnap , Ling Peng
Trends in Plant Science, 2018, 23 (12), pp.1116 - 1130. ⟨10.1016/j.tplants.2018.09.008⟩
Article dans une revue hal-02992919 v1
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Dendrimer-based magnetic resonance imaging agents for brain cancer

Ling Ding , Zhenbin Lyu , Dinesh Dhumal , Chai-Lin Kao , Monique Bernard et al.
Science China Materials, 2018, 61 (11), pp.1420 - 1443. ⟨10.1007/s40843-018-9323-6⟩
Article dans une revue hal-02992931 v1

Precise tuning of single molecule conductance in an electrochemical environment

Ling Peng , F. Chen , Z.-W. Hong , J.-F. Zheng , Laure Fillaud et al.
Nanoscale, 2018, 10 (15), pp.7026 - 7032. ⟨10.1039/c8nr00625c⟩
Article dans une revue hal-01792394 v1
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E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

Wenjun Lan , Benjamin Bian , Yi Xia , Samir Dou , Odile Gayet et al.
Scientific Reports, 2018, 8, pp.8330. ⟨10.1038/s41598-018-26613-z⟩
Article dans une revue hal-01947725 v1
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Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors

Philippe Garrigue , Jingjie Tang , Ling Ding , Ahlem Bouhlel , Aura Tintaru et al.
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (45), pp.11454-11459. ⟨10.1073/pnas.1812938115⟩
Article dans une revue hal-01947788 v1
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Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates

Zhengwei Zhou , Mei Cong , Mengyao Li , Aura Tintaru , Jia Li et al.
Chemical Communications, 2018, 54 (47), pp.5956 - 5959. ⟨10.1039/c8cc01221k⟩
Article dans une revue hal-02992951 v1
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Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery

Jing Ma , Shashwati Kala , Susan Yung , Tak Mao Chan , Yu Cao et al.
Molecular Therapy, 2018, 26 (1), pp.70 - 83. ⟨10.1016/j.ymthe.2017.11.006⟩
Article dans une revue hal-02992967 v2
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A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

Yiwen Dong , Tianzhu Yu , Ling Ding , Erik Laurini , Yuanyu Huang et al.
Journal of the American Chemical Society, 2018, 140 (47), pp.16264-16274. ⟨10.1021/jacs.8b10021⟩
Article dans une revue hal-02992903 v1
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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao , Xiaoxuan Liu , Ling Peng
Frontiers of Chemical Science and Engineering, 2017, 11 (4), pp.663 - 675. ⟨10.1007/s11705-017-1623-5⟩
Article dans une revue hal-01962995 v1

Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation

Mimi Chen , Zhengwei Zhou , Yaxiong Suo , Mengyao Li , Jianhua Yao et al.
New Journal of Chemistry, 2017, 41 (16), pp.8509-8519
Article dans une revue hal-01962989 v1

Potent drugless dendrimers

Zhenbin Lyu , Ling Peng
Nature Biomedical Engineering, 2017, 1 (9), pp.686 - 688. ⟨10.1038/s41551-017-0136-3⟩
Article dans une revue hal-01783444 v1

Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces

Samuel Hinman , Charles Ruiz , Yu Cao , Meghann Ma , Jingjie Tang et al.
ACS Applied Materials & Interfaces, 2016, 9 (1), pp.1029 - 1035. ⟨10.1021/acsami.6b11556⟩
Article dans une revue hal-01783435 v1

Robust Sierpiński triangle fractals on symmetry-mismatched Ag(100)

Xue Zhang , Na Li , L. Liu , Gaochen Gu , Chao Li et al.
Chemical Communications, 2016, 52 (69), pp.10578-10581. ⟨10.1039/c6cc04879j⟩
Article dans une revue hal-01766330 v1
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A Fluorinated Bola-Amphiphilic Dendrimer for On-Demand Delivery of siRNA, via Specific Response to Reactive Oxygen Species

Xiaoxuan Liu , Yang Wang , Chao Chen , Aura Tintaru , Yu Cao et al.
Advanced Functional Materials, 2016, 26 (47), pp.8594-8603. ⟨10.1002/adfm.201604192⟩
Article dans une revue hal-01459079 v1

Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing

Chao Chen , Paola Posocco , Xiaoxuan Liu , Qiang Cheng , Erik Laurini et al.
Small, 2016, 12 (27), pp.3667-3676. ⟨10.1002/smll.201503866⟩
Article dans une revue hal-01459075 v1
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Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Qi Cui , Su Yang , Peng Ye , E. Tian , Guoqiang Sun et al.
Nature Communications, 2016, 7, pp.10637. ⟨10.1038/ncomms10637⟩
Article dans une revue hal-01452670 v1

Hepatocellular Nuclear Factor 4 alpha (HNF-4 alpha) activation by saRNA rescues dyslipidemia and promotes favorable metabolic profile in a high fat diet (HFD) fed rat model.

Vikash Reebye , Kai-Wen Huang , Katherine Czysz , Simona Ciriello , Stehpanie Dorman et al.
Hepatology, 2016, 63 (1 SUPP), pp.794A. ⟨10.1002/hep.28799⟩
Article dans une revue hal-01452675 v1

Structural characterization of new defective molecules in poly(amidoamide)dendrimers by combining mass spectrometry and nuclear magnetic resonance

Aura Tintaru , Rémi Ungaro , Xiaoxiuan Liu , Chao Chen , Laurent Giordano et al.
Analytica Chimica Acta, 2015, 853, pp.451-459. ⟨10.1016/j.aca.2014.10.048⟩
Article dans une revue hal-01128946 v1

Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

T. Wei , C. Chen , J. Liu , C. Liu , A. M. Posocco et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (10), pp.2978-2983
Article dans une revue hal-01131206 v1

Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance

Y. Zhao , F. Chen , Y. Pan , Z. Li , X. Xue et al.
ACS Applied Materials & Interfaces, 2015, 7, pp.19295-19305
Article dans une revue hal-01222099 v1

Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrime

X. Liu , C. Liu , J. Zhou , C. Chen , F. Qu et al.
Nanoscale, 2015, 7, pp.3867-3875
Article dans une revue hal-01130071 v1

Shape separation of gold nanoparticles using a pH-responsive amphiphilic dendrimer according to their shape anisotropy distinction

M. Hao , C. Liu , Ling Peng , J. Li , W. Lu et al.
Journal of Colloid and Interface Science, 2015, 437, pp.311-315
Article dans une revue hal-01128932 v1

Pd-catalyzed oxidative C-H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides

G. Tang , M. Cong , Y. Xia , G. Quélever , Y. Fan et al.
Organic & Biomolecular Chemistry, 2015, 13, pp.110-114
Article dans une revue hal-01128969 v1

Microwave promoted C-O coupling for synthesizing O-aryloxytriazole nucleoside analogues

M. Cong , Y. Xia , J. Tang , L. Borge , G. Quéléver et al.
New Journal of Chemistry, 2015, 39, pp.3889-3893
Article dans une revue hal-01149759 v1

A 'click' chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins

Y. Wang , Z. Assaf , X. Liu , F. Ziarelli , A. Latifi et al.
Organic & Biomolecular Chemistry, 2014, 12 (33), pp.6470-6475. ⟨10.1039/c4ob01005a⟩
Article dans une revue hal-01067964 v1

Mixed ligand catalyst: a powerful tool in transition metal-catalyzed cross-coupling reactions

Y. Fn , M. Cong , Ling Peng
Chemistry - A European Journal, 2014, 20, pp.2698-2702
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An arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo

C. Liu , X. Liu , P. Rocchi , F. Qu , J. Iovanna et al.
Bioconjugate Chemistry, 2014, 25, pp.521-532
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A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo

V. Reebye , P. Sætrom , P.J. Mintz , K. Wen Huang , V. Lin et al.
Hepatology, 2014, 59 (1), pp.216-227. ⟨10.1002/hep.26669⟩
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Mimicking 2-oxoglutaric acid signaling function using molecular probes: insights from structural and functional investigations

Y. Wang , X. Liu , E. Laurini , P. Posocco , F. Ziarelli et al.
Organic & Biomolecular Chemistry, 2014, 12, pp.4723-4729
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Pd(dba)2 vs Pd2(dba)3 : An in-depth comparison of catalytic reactivity and mechanism via mixed-ligand promoted C-N and C-S coupling reactions

M. Cong , Y. Fan , J-M. Raimundo , J. Tang , Ling Peng
Organic Letters, 2014, 16, pp.4074-4077
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Conformational sensitivity of conjugated poly(ethylene oxide)-poly(amidoamine) molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study

Aura Tintaru , Christophe Chendo , Qi Wang , Stéphane Viel , Gilles Quéléver et al.
Analytica Chimica Acta, 2014, 808, pp.163--174. ⟨10.1016/j.aca.2013.08.030⟩
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Conformational sensibility of PEO-PAMAM hybrid molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study

A. Tintaru , C. Chendo , Qiang Wang , S. Viel , G. Quelever et al.
Analytica Chimica Acta, 2014, 808, pp.163-174
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Copper(II) binding to structurally flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach

M.F. Ottaviani , M. Cangiotti , A. Fattori , C. Coppola , P. Posocco et al.
Physical Chemistry Chemical Physics, 2014, 16, pp.685-694
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Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics

X. Liu , C. Liu , C.V. Catapano , Ling Peng , J. Zhou et al.
Biotechnology Advances, 2014, 32, pp.844-852
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Combination of dendrimer nanovector mediated small interfering RNA delivery to target Akt with clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer

S. Kala , A.S.C. Mak , X. Liu , P. Posoxxo , S. Pricl et al.
Journal of Medicinal Chemistry, 2014, 57, pp.2634-2642
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Conformational changes of small PAMAM dendrimers as a function of their charge state: a combined electrospray mass spectrometry, traveling-wave ion mobility and molecular modeling study

A. Tintaru , S. Pricl , L. Denbigh , X. Liu , Ling Peng et al.
International Journal of Mass Spectrometry, 2013, 354-355, pp.235-241
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Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing

P. Posocco , X. Liu , E. Laurini , D. Marson , C. Chen et al.
Molecular Pharmaceutics, 2013, 10, pp.3262-3273
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C-S coupling using a mixed-ligand Pd catalyst: a highly effective strategy for synthesizing arylthio-substituted heterocycles

M. Cong , Y. Fan , J-L. Raimundo , Y. Xia , Yehan Liu et al.
Chemistry - A European Journal, 2013, 19, pp.17267-17272
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Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer

Y-F. Chen , Z. Dong , Y. Xia , J. Tang , Ling Peng et al.
Cancer Science, 2013, 104 (12), pp.1683-1689. ⟨10.1111/cas.12277⟩
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A bola-phospholipid containing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies

Y. Xia , K. Sengupta , A. Maggiani , F. Qu , Ling Peng
Organic & Biomolecular Chemistry, 2013, 11, pp.5000-5005
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Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function

X. Liu , Y. Wang , E. Laurini , P. Posocco , H. Chen et al.
Organic Letters, 2013, 15, pp.4664-4665
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19F NMR: a valuable tool for studying biological events

H. Chen , S. Viel , F. Ziarelli , Ling Peng
Chemical Society Reviews, 2013, 42, pp.7971-82. ⟨10.1039/c3cs60129c⟩
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Photoactivatable lipid probes to study biomembranes using photoaffinity labeling

Y. Xia , Ling Peng
Chemical Reviews, 2013, 113, pp.7880-7929
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F-19 NMR: a valuable tool for studying biological events

Han Chen , Stéphane Viel , Fabio Ziarelli , Ling Peng
Chemical Society Reviews, 2013, 42 (20), pp.7971--7982. ⟨10.1039/c3cs60129c⟩
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Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells

M-F. Lang , S. Yang , C. Zhao , G. Sun , K. Murai et al.
PLoS ONE, 2012, 7 (4), pp.e36248
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Rationalizing the F...S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid

Yi Xia , Stéphane Viel , Yang Wang , Fabio Ziarelli , Erik Laurini et al.
Chemical Communications, 2012, 48 (36), pp.4284--4286. ⟨10.1039/c2cc18147a⟩
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Targeting heat shock factor I with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer

Y. Xia , Yehan Liu , P. Rocchi , M. Wang , Y. Fan et al.
Cancer Letters, 2012, 318, pp.145-153
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Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer

X. Liu , C. Liu , E. Laurini , P. Posocco , S. Pricl et al.
Molecular Pharmaceutics, 2012, 9 (3), pp.470-481
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Dendrimers as non-viral vectors for siRNA delivery

X. Liu , P. Rocchi , Ling Peng
New Journal of Chemistry, 2012, 36, pp.256-263
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An efficient mixed-ligand Pd catalytic system to promote C-N coupling for the synthesis of N-arylaminotriazole nucleosides

Y. Fan , X. Xia , J. Tang , F. Ziarelli , F. Qu et al.
Chemistry - A European Journal, 2012, 18, pp.2221-2225
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A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity

Y. Xia , M. Wang , O. Demaria , J. Tang , P. Rocchi et al.
Journal of Medicinal Chemistry, 2012, 55 (11), pp.5642-5646. ⟨10.1021/jm300534u⟩
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HR-MAS NMR to investigate protein-ligand binding events in mass-limited samples

F. Ziarelli , Ling Peng , C-C. Zhang , S. Viel
Journal of Pharmaceutical and Biomedical Analysis, 2012, 59, pp.13-17
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The seemingly trivial yet challenging synthesis of poly(aminoester) dendrimers

Y. Wang , G. Quélever , Ling Peng
Current Medicinal Chemistry, 2012, 19, pp.5011
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An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo

T. Yu , X. Liu , A-L. Bolcato-Bellemin , Y. Wang , C. Liu et al.
Angewandte Chemie International Edition, 2012, 51, pp.8478-8484
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High resolution magic angle spinning NMR to investigate ligand-receptor binding events for mass-limited samples in liquids

Fabio Ziarelli , Ling Peng , Cheng-Cai Zhang , Stéphane Viel
Journal of Pharmaceutical and Biomedical Analysis, 2012, 59, pp.13--17. ⟨10.1016/j.jpba.2011.10.006⟩
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Targeting heat shock response pathway to treat pancreatic cancer

Y. Xia , P. Rocchi , J. Iovanna , Ling Peng
Drug Discovery Today, 2012, 17, pp.35-43
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Rationally designed structurally flexible PAMAM dendrimers as efficient vectors for DNA transfection in vitro and in vivo to mouse thymus

X. Liu , J. Wu , M. Yamine , J. Zhou , P. Posocco et al.
Bioconjugate Chemistry, 2011, 22, pp.2461-2473
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Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus

Xiaoxuan Liu , Jiangyu Wu , Miriam Yammine , Jiehua Zhou , Paola Posocco et al.
Bioconjugate Chemistry, 2011, 22 (12), pp.2461--2473. ⟨10.1021/bc200275g⟩
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Active-Targeted Nanotherapy Strategies for Prostate Cancer

M. Katsogiannou , Ling Peng , C. Catapano , P. Rocchi
Current Cancer Drug Targets, 2011, 11, pp.954-965
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Electrospray tandem mass spectrometry of poly(amino)ester dendrimers: dissociation rules and structural characterization of defective molecules

A. Tintaru , C. Chendo , V. Monnier , C. Bouillon , G. Quelever et al.
International Journal of Mass Spectrometry, 2011, 308, pp.56-64. ⟨10.1016/j.ijms.2011.07.021⟩
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2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria

X.J. Liu , H. Chen , E. Laurini , Y. Wang , V. Dal Col et al.
Organic Letters, 2011, 13 (11), pp.2924-2927. ⟨10.1021/ol2009544⟩
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Systemic administration of dendrimer-siRNA complexes efficiently suppresses HIV-1 infection

J. Zhou , P. Neff , X. Liu , J. Zhang , H. Li et al.
Molecular Therapy, 2011, 19, pp.2228-2238
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Photoactivatable phospholipids bearing tetrafluorophenylazido chromophores exhibit unprecedented protonation state - dependent 19F-NMR signals

Y. Xia , F. Qu , A. Maggiani , K. Sengupta , C. Liu et al.
Organic Letters, 2011, 13, pp.4248-4251
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Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus

M. Wang , R. Zhu , Z. Fan , Y. Fu , L. Feng et al.
Bioorganic and Medicinal Chemistry Letters, 2011, 21, pp.354-357
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Novel triazole nucleoside analogs with anticancer activity

M. Wang , Y. Xia , F. Qu , Ling Peng
Chinese Journal of Medicinal Chemistry, 2010, 20 (5), pp.362
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N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer

Yehan Liu , Y. Xia , Y. Fan , A. Maggiani , P. Rocchi et al.
Bioorganic and Medicinal Chemistry Letters, 2010, 20, pp.2503-2507
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Structural characterization of poly(amino)ester dendrimers and related impurities by electrospray tandem mass spectrometry

A. Tintaru , V. Monnier , C. Bouillon , R. Giordanengo , Ling Peng et al.
Rapid Communications in Mass Spectrometry, 2010, 24, pp.2207-2216
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A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells

M.H. Wang , Y. Xia , Y.T. Fan , P. Rocchi , F.Q. Qu et al.
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (20), pp.5979-5983. ⟨10.1016/j.bmcl.2010.08.093⟩
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Synthesis of Poly(amino)ester Dendrimers via Active Cyanomethyl Ester Intermediates

C. Bouillon , A. Tintaru , V. Monnier , L. Charles , G. Quelever et al.
Journal of Organic Chemistry, 2010, 75, pp.8685-8688
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Ligand-Mediated Highly Effective and Selective C-N Coupling for Synthesizing Bioactive N-Aryltriazole Acyclonucleosides

Y. Fan , Y. Xia , J. Tang , P. Rocchi , F. Qu et al.
Organic Letters, 2010, 12 (24), pp.5712-5715
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S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus

Yehan Liu , Y. Xia , W. Li , M. Cong , A. Maggiani et al.
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (12), pp.3610-3613
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Triazole Nucleoside Derivatives Bearing Aryl Functionalities on the Nucleobases Show Antiviral and Anticancer Activity

Y. Xia , F. Qu , Ling Peng
Mini Reviews in Medicinal Chemistry / Mini-Reviews in Medicinal Chemistry, 2010, 10 (9), pp.806-821
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Cu-mediated Selective N-arylation of Aminotriazole Acyclonucleosides

W. Li , Y. Fan , P. Rocchi , R. Zhu , F. Qu et al.
Helvetica Chimica Acta, 2009, 92, pp.1503-1513
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PAMAM dendrimer mediated siRNA delivery to target heat-shock protein 27 and produce potent antiproliferation effect on prostate cancer PC-3 cells

X. Liu , P. Rocci , F. Qu , S. Zheng , Z. Liang et al.
ChemMedChem, 2009, 4, pp.1302-1310
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Efficient synthesis of esters containing tertiary amine functionalities via active cyanomethyl ester intermediates

C. Bouillon , G. Quéléver , Ling Peng
Tetrahedron Letters, 2009, 50 (30), pp.4346-4349
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Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer

Y. Xia , Yehan Liu , J. Wan , M. Wang , P. Rocchi et al.
Journal of Medicinal Chemistry, 2009, 52 (19), pp.6083-6096. ⟨10.1021/jm900960v⟩
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Complexing photolabile cholinergic ligands with synthetic and biological receptors: a dynamic survey

A. Specht , S. Loudwig , Ling Peng , M. Goeldner
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 65, pp.157-163
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Discovery of novel arylethynyltriazole Ribonucleosides with selective and effective antiviral and anti-proliferative activity

J. Wan , Y. Xia , Yehan Liu , M. Wang , P. Rocchi et al.
Journal of Medicinal Chemistry, 2009, 52, pp.1144-1155
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Bitriazolyl Acyclonucleosides with Antiviral Activity against Tobacco Mosaic Virus

W. Li , Y. Xia , Z. Fan , F. Qu , Q. Wu et al.
Tetrahedron Letters, 2008, 49, pp.2804-2809
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Arylethynyltriazole Acyclonucleosides Inhibit Hepatitis C Virus Replication

R. Zhu , M. Wang , Y. Xia , F. Qu , J. Neyts et al.
Bioorganic and Medicinal Chemistry Letters, 2008, 18, pp.3321-3327
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Direct Synthesis of 5-Aryltriazole Acyclonucleosides via Suzuki Coupling in Aqueous Solution

R. Zhu , F. Qu , G. Quelever , Ling Peng
Tetrahedron Letters, 2007, 48, pp.2389-2393
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Palmitoylation is required for efficient Fas cell death signaling.

Krittalak Chakrabandhu , Zoltán Hérincs , Sébastien Huault , Britta Dost , Ling Peng et al.
EMBO Journal, 2007, 26 (1), pp.209-20. ⟨10.1038/sj.emboj.7601456⟩
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Importance of Size to Charge Ratio in Construction of Stable and Uniform Nanoscale RNA/dendrimer Complexes

X.-C. Shen , J. Zhou , X. Liu , J. Wu , F. Qu et al.
Organic & Biomolecular Chemistry, 2007, 5, pp.3674-3681
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Synthesis of Bitriazolyl Nucleosides and Unexpectedly Different Reactivity of Azidotriazole Nucleoside Isomers in Huisgen Reaction

Y. Xia , W. Li , F. Qu , Z. Fan , X. Liu et al.
Organic & Biomolecular Chemistry, 2007, 5, pp.1695-1701
Article dans une revue hal-00303626 v1

Propagation of structural deviation of poly(amido)amine fan-shape dendrimers (generations 0 to 3) characterized by MALDI and electrospray mass spectrometry

R. Giordanengo , M. Mazarin , J. Wu , Ling Peng , L. Charles
International Journal of Mass Spectrometry, 2007, 266 (1-3), pp.62-75. ⟨10.1016/j.ijms.2007.07.002⟩
Article dans une revue istex hal-00303628 v1

Palmitoylation is Required for Fas to Trigger Cell Death Signaling

Z. Herincs , K. Chakrabandhu , B. Dost , Ling Peng , F. Conchonaud et al.
EMBO Journal, 2007, 26, pp.209-220
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Heterocyst differentition and pattern formation in cyanobacteria: a chorus of signals

C.-C. Zhang , S. Laurent , S. Sakr , Ling Peng , S. Bédu
Molecular Microbiology, 2006, 59(2), pp.367-375
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Cooperative binding and self-assembling behavior of cationic low-molecular-weight dendrons with RNA molecules

J. Zhou , J. Wu , X.X. Liu , F. Qu , M. Xiao et al.
Organic & Biomolecular Chemistry, 2006, 4(3), pp.581-585
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PAMAM dendrimers for efficient siRNA delivery and potent gene silencing

J. Zhou , J. Wu , N. Hafdi , J.-P. Behr , P. Erbacher et al.
Chemical Communications, 2006, 22, pp.2362-2364. ⟨10.1039/B601381C⟩
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Para-Sulfonated Calixarenes Used as Synthetic Receptors for Complexing Photolabile Cholinergic Ligand

Alexandre Specht , Fabio Ziarelli , Philippe Bernard , Maurice Goeldner , Ling Peng
Helvetica Chimica Acta, 2005, 88 (10), pp.2641-2653. ⟨10.1002/hlca.200590205⟩
Article dans une revue istex hal-00129989 v1