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Ling PENG

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P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis

Jing Ma , Sally Kit Yan To , Katie Sze Wai Fung , Kun Wang , Jiangwen Zhang
Cell Reports, 2025, 44 (1), pp.115096. ⟨10.1016/j.celrep.2024.115096⟩
Journal articles hal-04881848v1
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Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group

Alessia Cavazza , Francisco J Molina-Estévez , Álvaro Plaza Reyes , Victor Ronco , Asma Naseem
Molecular Therapy - Nucleic Acids, 2025, 36 (1), pp.102457. ⟨10.1016/j.omtn.2025.102457⟩
Journal articles hal-04931602v1
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Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis

Zeyu Shi , Margarita Artemenko , Weiyu Yu , Ming Zhang , Canhui Yi
ACS Applied Materials & Interfaces, 2025, ⟨10.1021/acsami.4c12857⟩
Journal articles hal-04868442v1
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STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy

Miao Zhang , Yongling Wang , Benhao Li , Bowei Yang , Mengyao Zhao
Advanced Materials, inPress, ⟨10.1002/adma.202412654⟩
Journal articles hal-04931603v1
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Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate

Nian Zhang , Dinesh Dhumal , Shanny Hsuan Kuo , Shi Qian Lew , Pankaj Patil
Science Advances , 2024, 10 (39), pp.eadn8117. ⟨10.1126/sciadv.adn8117⟩
Journal articles hal-04710306v1
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Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy

Tom Roussel , Daniel Ferry , Artemis Kosta , Dalila Miele , Giuseppina Sandri
ACS Materials Au, 2024
Journal articles hal-04622011v2
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Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study

Tom Roussel , Twiany Cruz-Dubois , Beatrice Louis , Erik Laurini , Ling Ding
Journal of materials chemistry‎ B, inPress, ⟨10.1039/D4TB01266F⟩
Journal articles hal-04851748v1

The synergistic neurovascular electro-healing of infected diabetic wounds by a multifaceted absorbable ion-conductive adhesive patch

Wenlong Wei , Jiayi Zheng , Ziru Liu , Ziqiu Li , Xiangyu Chen
Chemical Engineering Journal, 2024, 500, pp.156387. ⟨10.1016/j.cej.2024.156387⟩
Journal articles hal-04749088v1
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Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases

Noah King , Dinesh Dhumal , Shi Qian Lew , Shanny Hsuan Kuo , Christina Galanakou
ACS Infectious Diseases, 2024, 10 (2), pp.453-466. ⟨10.1021/acsinfecdis.3c00425⟩
Journal articles hal-04465187v1
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Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors

Zhenbin Lyu , Brigino Ralahy , Teodora-Adriana Perles-Barbacaru , Ling Ding , Yifan Jiang
Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (25), pp.e2322403121. ⟨10.1073/pnas.2322403121⟩
Journal articles hal-04610233v1
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Capture and flocculation of toxic cyanobacteria by amphiphilic peptide dendrimers for mitigating harmful blooms

Heng Zheng , Pier-Luc Tremblay , Wang Chen , Qi Wang , Danni Hu
Chemical Engineering Journal, 2024, ⟨10.1016/j.cej.2024.151382⟩
Journal articles hal-04550900v1
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Development of an efficient NUPR1 inhibitor with anticancer activity

Xi Liu , Ana Jimenez-Alesanco , Zexian Li , Bruno Rizzuti , José L Neira
Scientific Reports, 2024, 14 (1), pp.29515. ⟨10.1038/s41598-024-79340-z⟩
Journal articles hal-04813298v1
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Cargo-selective and adaptive delivery of nucleic acid therapeutics by bola-amphiphilic dendrimers

Jiaxuan Chen , Dandan Zhu , Baoping Lian , Kangjie Shi , Peng Chen
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (21), pp.e2220787120. ⟨10.1073/pnas.2220787120⟩
Journal articles hal-04099741v1
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A PD‐L1 Antibody‐Conjugated PAMAM Dendrimer Nanosystem for Simultaneously Inhibiting Glycolysis and Promoting Immune Response in Fighting Breast Cancer

Peng Zhang , Zhi Li , Weiling Cao , Jingjie Tang , Yi Xia
Advanced Materials, inPress, ⟨10.1002/adma.202305215⟩
Journal articles hal-04193228v1
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Amphiphilic Dendrimer Doping Enhanced pH-Sensitivity of Liposomal Vesicle for Effective Co-delivery Toward Synergistic Ferroptosis-Apoptosis Therapy of Hepatocellular Carcinoma

Yanhong Su , Zhao Zhang , Leo Tsz , Ling Peng , Ligong Lu
Advanced Healthcare Materials, 2023, 12 (6), pp.2202663. ⟨10.1002/adhm.202202663⟩
Journal articles hal-03940472v1
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Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?

Christina Galanakou , Dinesh Dhumal , Ling Peng
Biomaterials Science, inPress, ⟨10.1039/D2BM01878K⟩
Journal articles hal-04009305v1
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Progress and Harmonization of Gene Editing to Treat Human Diseases (Proceeding of COST Action CA21113 GenE-HumDi)

Alessia Cavazza , Ayal Hendel , Rasmus O Bak , Paula Rio , Marc Güell
Molecular Therapy - Nucleic Acids, 2023, ⟨10.1016/j.omtn.2023.102066⟩
Journal articles hal-04283508v1
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Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking

Yifan Jiang , Zhenbin Lyu , Brigino Ralahy , Juan Liu , Tom Roussel
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, ⟨10.1073/pnas.2215308120⟩
Journal articles hal-03977439v1
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Modular Self‐Assembling Dendrimer Nanosystems for Magnetic Resonance And Multimodality Imaging of Tumors

Ling Ding , Zhenbin Lyu , Teodora‐adriana Perles-Barbacaru , Adela Ya‐ting Huang , Baoping Lian
Advanced Materials, 2023, ⟨10.1002/adma.202308262⟩
Journal articles hal-04315766v2
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Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective

Jiaxuan Chen , Dandan Zhu , Xiaoxuan Liu , Ling Peng
Accounts of Materials Research, 2022, ⟨10.1021/accountsmr.1c00272⟩
Journal articles hal-03674633v1
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Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms

Dinesh Dhumal , Bar Maron , Einav Malach , Zhenbin Lyu , Ling Ding
Nanoscale, 2022, ⟨10.1039/d2nr02305a⟩
Journal articles hal-03691397v1
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Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction

Ya-Ting Huang , C.-L Kao , A Selvaraj , Ling Peng
Materials Today Chemistry, 2022, ⟨10.1016/j.mtchem.2022.101285⟩
Journal articles hal-03878638v1
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Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Yunfang Xiong , Ran Ke , Qingyu Zhang , Wenjun Lan , Wanjun Yuan
Advanced Science, 2022, pp.2200562. ⟨10.1002/advs.202200562⟩
Journal articles hal-03701082v1

NUPR1 protects against hyperPARylation-dependent cell death

Patricia Santofimia-Castano , Can Huang , Xi Liu , Yi Xia , Stephane Audebert
Communications Biology, 2022, 5 (1), ⟨10.1038/s42003-022-03705-1⟩
Journal articles hal-04084989v1

A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery

Chi Ma , Dandan Zhu , Wenyi Lin , Ying Li , Yuanzheng Huang
Chemical Communications, 2022, ⟨10.1039/D1CC06655B⟩
Journal articles hal-03536584v1
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Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Wenzheng Zhang , Dinesh Dhumal , Xiaolei Zhu , Brigino Ralahy , Aleksandra Ellert-Miklaszewska
Chemistry - A European Journal, inPress, ⟨10.1002/chem.202201400⟩
Journal articles hal-03725167v1

Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

Bo Hu , Bo Li , Kun Li , Yuanyuan Liu , Chunhui Li
Science Advances , 2022, 8 (7), ⟨10.1126/sciadv.abm1418⟩
Journal articles hal-03590890v1

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

Can Huang , Patricia Santofimia-Castaño , Xi Liu , Yi Xia , Ling Peng
Cell Death Discovery, 2021, 7 (1), pp.269. ⟨10.1038/s41420-021-00662-2⟩
Journal articles hal-03536613v1
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Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

Bruno Rizzuti , Wenjun Lan , Patricia Santofimia-Castaño , Zhengwei Zhou , Adrián Velázquez-Campoy
Biomolecules, 2021, 11 (10), pp.1453. ⟨10.3390/biom11101453⟩
Journal articles hal-03536609v1

Dendrimeric Nanosystem Consistently Circumvents Heterogeneous Drug Response and Resistance in Pancreatic Cancer

Juan Liu , Chao Chen , Tuo Wei , Odile Gayet , Céline Loncle
Energy Exploration and Exploitation, 2021, 1 (1), pp.21-34. ⟨10.1002/EXP.20210003⟩
Journal articles hal-03361161v1
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A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine

Mei Cong , Guangling Xu , Shaoyou Yang , Jing Zhang , Wenzheng Zhang
Chinese Chemical Letters, 2021, ⟨10.1016/j.cclet.2021.11.083⟩
Journal articles hal-03536604v1
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Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen , Aleksandra Ellert-Miklaszewska , Stefano Garofalo , Arindam K Dey , Jingjie Tang
Nature Protocols, 2021, ⟨10.1038/s41596-020-00418-9⟩
Journal articles hal-03041303v1
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An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Dinesh Dhumal , Wenjun Lan , Ling Ding , Yifan Jiang , Zhenbin Lyu
Nano Research, 2021, ⟨10.1007/s12274-020-3216-8⟩
Journal articles hal-03041310v1
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Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study

Ling Ding , Zhenbin Lyu , Beatrice Louis , Aura Tintaru , Erik Laurini
Small, 2020, 16, pp.301-304. ⟨10.1002/smll.202003290⟩
Journal articles hal-02992689v1
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Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

Yanhua Zhang , Xi Liu , Yun Lin , Baoping Lian , Wenjun Lan
Chemical Communications, 2020, 56 (69), pp.10014-10017. ⟨10.1039/d0cc04660d⟩
Journal articles hal-02992738v1
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Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amidoamine) dendrimers

Zhenbin Lyu , Ling Ding , Aura Tintaru , Ling Peng
Accounts of Chemical Research, 2020, ⟨10.1021/acs.accounts.0c00589⟩
Journal articles hal-03041818v1
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Therapeutic siRNA: state of the art

Bo Hu , Liping Zhong , Yuhua Weng , Ling Peng , Yuanyu Huang
Signal Transduction and Targeted Therapy, 2020, 5 (1), ⟨10.1038/s41392-020-0207-x⟩
Journal articles hal-02992725v1
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ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Wenjun Lan , Patricia Santofimia-Castaño , Mirna Swayden , Yi Xia , Zhengwei Zhou
JCI Insight, 2020, 5 (18), pp.e138117. ⟨10.1172/jci.insight.138117⟩
Journal articles hal-03877804v1

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Ling Ding , Zhenbin Lyu , Aura Tintaru , Erik Laurini , Domenico Marson
Chemical Communications, 2020, 56 (2), pp.301-304. ⟨10.1039/c9cc07750b⟩
Journal articles hal-02480314v1
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Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates

Yanhua Zhang , Yun Lin , Qianqian Hou , Xi Liu , Sabrina Pricl
Organic & Biomolecular Chemistry, 2020, ⟨10.1039/d0ob02164d⟩
Journal articles hal-03041312v1
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Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Stefano Garofalo , Germana Cocozza , Alessandra Porzia , Maurizio Inghilleri , Marcello Raspa
Nature Communications, 2020, 11 (1), pp.1773. ⟨10.1038/s41467-020-15644-8⟩
Journal articles hal-02551996v1
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Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

Kai-Wen Huang , Vikash Reebye , Katherine Czysz , Simona Ciriello , Stephanie Dorman
Molecular Therapy - Nucleic Acids, 2020, 19, pp.361 - 370. ⟨10.1016/j.omtn.2019.10.044⟩
Journal articles hal-02992731v1
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Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma

Wenjun Lan , Patricia Santofimia-Castaño , Yi Xia , Zhengwei Zhou , Can Huang
Cancer Letters, 2020, 486, pp.8-17. ⟨10.1016/j.canlet.2020.04.024⟩
Journal articles hal-02994552v1
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Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Zhengwei Zhou , Biyao Luo , Xi Liu , Mimi Chen , Wenjun Lan
Chemical Communications, 2019, 55 (61), pp.8919 - 8922. ⟨10.1039/c9cc04084f⟩
Journal articles hal-02992833v1
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Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

Patricia Santofimia-Castaño , Yi Xia , Ling Peng , Adrián Velázquez-Campoy , Olga Abián
Cells, 2019, 8 (11), pp.1453. ⟨10.3390/cells8111453⟩
Journal articles hal-02480322v1
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Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Patricia Santofimia-Castaño , Yi Xia , Wenjun Lan , Zhengwei Zhou , Can Huang
Journal of Clinical Investigation, 2019, 129 (6), pp.2500 - 2513. ⟨10.1172/jci127223⟩
Journal articles hal-02992816v1

Targeting intrinsically disordered proteins involved in cancer

Patricia Santofimia-Castaño , Bruno Rizzuti , Yi Xia , Olga Abián , Ling Peng
Cellular and Molecular Life Sciences, 2019, ⟨10.1007/s00018-019-03347-3⟩
Journal articles hal-02491357v1

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

Patricia Santofimia-Castaño , Bruno Rizzuti , Yi Xia , Olga Abián , Ling Peng
Molecular & Cellular Oncology, 2019, pp.1-3. ⟨10.1080/23723556.2019.1612678⟩
Journal articles hal-02140372v1
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Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector

Aleksandra Ellert-Miklaszewska , Natalia Ochocka , Marta Maleszewska , Ling Ding , Erik Laurini
Nanomedicine, 2019, 14 (18), pp.2441 - 2458. ⟨10.2217/nnm-2019-0176⟩
Journal articles hal-02992806v1
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Poly(amidoamine) dendrimers: covalent and supramolecular synthesis

Z. Lyu , L. Ding , A.Y.T. Huang , L. Kao , Ling Peng
Materials Today Chemistry, 2019, 13, pp.34-48. ⟨10.1016/j.mtchem.2019.04.004⟩
Journal articles hal-02140381v1
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Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates

Zhengwei Zhou , Mei Cong , Mengyao Li , Aura Tintaru , Jia Li
Chemical Communications, 2018, 54 (47), pp.5956 - 5959. ⟨10.1039/c8cc01221k⟩
Journal articles hal-02992951v1
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A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

Yiwen Dong , Tianzhu Yu , Ling Ding , Erik Laurini , Yuanyu Huang
Journal of the American Chemical Society, 2018, 140 (47), pp.16264-16274. ⟨10.1021/jacs.8b10021⟩
Journal articles hal-02992903v1
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Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery

Jing Ma , Shashwati Kala , Susan Yung , Tak Mao Chan , Yu Cao
Molecular Therapy, 2018, 26 (1), pp.70 - 83. ⟨10.1016/j.ymthe.2017.11.006⟩
Journal articles hal-02992967v2
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Dendrimer-based magnetic resonance imaging agents for brain cancer

Ling Ding , Zhenbin Lyu , Dinesh Dhumal , Chai-Lin Kao , Monique Bernard
Science China Materials, 2018, 61 (11), pp.1420 - 1443. ⟨10.1007/s40843-018-9323-6⟩
Journal articles hal-02992931v1
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Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria

Cheng-Cai Zhang , Cong-Zhao Zhou , Robert L Burnap , Ling Peng
Trends in Plant Science, 2018, 23 (12), pp.1116 - 1130. ⟨10.1016/j.tplants.2018.09.008⟩
Journal articles hal-02992919v1

Precise tuning of single molecule conductance in an electrochemical environment

Ling Peng , F. Chen , Z.-W. Hong , J.-F. Zheng , Laure Fillaud
Nanoscale, 2018, 10 (15), pp.7026 - 7032. ⟨10.1039/c8nr00625c⟩
Journal articles hal-01792394v1
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Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors

Philippe Garrigue , Jingjie Tang , Ling Ding , Ahlem Bouhlel , Aura Tintaru
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (45), pp.11454-11459. ⟨10.1073/pnas.1812938115⟩
Journal articles hal-01947788v1
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E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

Wenjun Lan , Benjamin Bian , Yi Xia , Samir Dou , Odile Gayet
Scientific Reports, 2018, 8, pp.8330. ⟨10.1038/s41598-018-26613-z⟩
Journal articles hal-01947725v1
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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao , Xiaoxuan Liu , Ling Peng
Frontiers of Chemical Science and Engineering, 2017, 11 (4), pp.663 - 675. ⟨10.1007/s11705-017-1623-5⟩
Journal articles hal-01962995v1

Acyclonucleosides bearing coplanar arylethynyltriazole nucleobases: synthesis, structural analysis, and biological evaluation

Mimi Chen , Zhengwei Zhou , Yaxiong Suo , Mengyao Li , Jianhua Yao
New Journal of Chemistry, 2017, 41 (16), pp.8509-8519
Journal articles hal-01962989v1

Potent drugless dendrimers

Zhenbin Lyu , Ling Peng
Nature Biomedical Engineering, 2017, 1 (9), pp.686 - 688. ⟨10.1038/s41551-017-0136-3⟩
Journal articles hal-01783444v1

Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces

Samuel Hinman , Charles Ruiz , Yu Cao , Meghann Ma , Jingjie Tang
ACS Applied Materials & Interfaces, 2016, 9 (1), pp.1029 - 1035. ⟨10.1021/acsami.6b11556⟩
Journal articles hal-01783435v1
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Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Qi Cui , Su Yang , Peng Ye , E. Tian , Guoqiang Sun
Nature Communications, 2016, 7, pp.10637. ⟨10.1038/ncomms10637⟩
Journal articles hal-01452670v1

Hepatocellular Nuclear Factor 4 alpha (HNF-4 alpha) activation by saRNA rescues dyslipidemia and promotes favorable metabolic profile in a high fat diet (HFD) fed rat model.

Vikash Reebye , Kai-Wen Huang , Katherine Czysz , Simona Ciriello , Stehpanie Dorman
Hepatology, 2016, 63 (1 SUPP), pp.794A. ⟨10.1002/hep.28799⟩
Journal articles hal-01452675v1

Robust Sierpiński triangle fractals on symmetry-mismatched Ag(100)

Xue Zhang , Na Li , L. Liu , Gaochen Gu , Chao Li
Chemical Communications, 2016, 52 (69), pp.10578-10581. ⟨10.1039/c6cc04879j⟩
Journal articles hal-01766330v1
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A Fluorinated Bola-Amphiphilic Dendrimer for On-Demand Delivery of siRNA, via Specific Response to Reactive Oxygen Species

Xiaoxuan Liu , Yang Wang , Chao Chen , Aura Tintaru , Yu Cao
Advanced Functional Materials, 2016, 26 (47), pp.8594-8603. ⟨10.1002/adfm.201604192⟩
Journal articles hal-01459079v1

Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing

Chao Chen , Paola Posocco , Xiaoxuan Liu , Qiang Cheng , Erik Laurini
Small, 2016, 12 (27), pp.3667-3676. ⟨10.1002/smll.201503866⟩
Journal articles hal-01459075v1

Structural characterization of new defective molecules in poly(amidoamide)dendrimers by combining mass spectrometry and nuclear magnetic resonance

Aura Tintaru , Rémi Ungaro , Xiaoxiuan Liu , Chao Chen , Laurent Giordano
Analytica Chimica Acta, 2015, 853, pp.451-459. ⟨10.1016/j.aca.2014.10.048⟩
Journal articles hal-01128946v1

Shape separation of gold nanoparticles using a pH-responsive amphiphilic dendrimer according to their shape anisotropy distinction

M. Hao , C. Liu , Ling Peng , J. Li , W. Lu
Journal of Colloid and Interface Science, 2015, 437, pp.311-315
Journal articles hal-01128932v1

Pd-catalyzed oxidative C-H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides

G. Tang , M. Cong , Y. Xia , G. Quélever , Y. Fan
Organic & Biomolecular Chemistry, 2015, 13, pp.110-114
Journal articles hal-01128969v1

Microwave promoted C-O coupling for synthesizing O-aryloxytriazole nucleoside analogues

M. Cong , Y. Xia , J. Tang , L. Borge , G. Quéléver
New Journal of Chemistry, 2015, 39, pp.3889-3893
Journal articles hal-01149759v1

Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrime

X. Liu , C. Liu , J. Zhou , C. Chen , F. Qu
Nanoscale, 2015, 7, pp.3867-3875
Journal articles hal-01130071v1

Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance

Y. Zhao , F. Chen , Y. Pan , Z. Li , X. Xue
ACS Applied Materials & Interfaces, 2015, 7, pp.19295-19305
Journal articles hal-01222099v1

Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

T. Wei , C. Chen , J. Liu , C. Liu , A. M. Posocco
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (10), pp.2978-2983
Journal articles hal-01131206v1

A 'click' chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins

Y. Wang , Z. Assaf , X. Liu , F. Ziarelli , A. Latifi
Organic & Biomolecular Chemistry, 2014, 12 (33), pp.6470-6475. ⟨10.1039/c4ob01005a⟩
Journal articles hal-01067964v1

Combination of dendrimer nanovector mediated small interfering RNA delivery to target Akt with clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer

S. Kala , A.S.C. Mak , X. Liu , P. Posoxxo , S. Pricl
Journal of Medicinal Chemistry, 2014, 57, pp.2634-2642
Journal articles hal-00992909v1

Pd(dba)2 vs Pd2(dba)3 : An in-depth comparison of catalytic reactivity and mechanism via mixed-ligand promoted C-N and C-S coupling reactions

M. Cong , Y. Fan , J-M. Raimundo , J. Tang , Ling Peng
Organic Letters, 2014, 16, pp.4074-4077
Journal articles hal-01067963v1

Conformational sensitivity of conjugated poly(ethylene oxide)-poly(amidoamine) molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study

Aura Tintaru , Christophe Chendo , Qi Wang , Stéphane Viel , Gilles Quéléver
Analytica Chimica Acta, 2014, 808, pp.163--174. ⟨10.1016/j.aca.2013.08.030⟩
Journal articles hal-01460547v1

Conformational sensibility of PEO-PAMAM hybrid molecules to cations adducted upon electrospray ionization - A mass spectrometry, ion mobility and molecular modeling study

A. Tintaru , C. Chendo , Qiang Wang , S. Viel , G. Quelever
Analytica Chimica Acta, 2014, 808, pp.163-174
Journal articles hal-00975038v1

Copper(II) binding to structurally flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach

M.F. Ottaviani , M. Cangiotti , A. Fattori , C. Coppola , P. Posocco
Physical Chemistry Chemical Physics, 2014, 16, pp.685-694
Journal articles hal-00919576v1

Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics

X. Liu , C. Liu , C.V. Catapano , Ling Peng , J. Zhou
Biotechnology Advances, 2014, 32, pp.844-852
Journal articles hal-01021095v1

Mixed ligand catalyst: a powerful tool in transition metal-catalyzed cross-coupling reactions

Y. Fn , M. Cong , Ling Peng
Chemistry - A European Journal, 2014, 20, pp.2698-2702
Journal articles hal-00975063v1

Mimicking 2-oxoglutaric acid signaling function using molecular probes: insights from structural and functional investigations

Y. Wang , X. Liu , E. Laurini , P. Posocco , F. Ziarelli
Organic & Biomolecular Chemistry, 2014, 12, pp.4723-4729
Journal articles hal-01021094v1

A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo

V. Reebye , P. Sætrom , P.J. Mintz , K. Wen Huang , V. Lin
Hepatology, 2014, 59 (1), pp.216-227. ⟨10.1002/hep.26669⟩
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An arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo

C. Liu , X. Liu , P. Rocchi , F. Qu , J. Iovanna
Bioconjugate Chemistry, 2014, 25, pp.521-532
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F-19 NMR: a valuable tool for studying biological events

Han Chen , Stéphane Viel , Fabio Ziarelli , Ling Peng
Chemical Society Reviews, 2013, 42 (20), pp.7971--7982. ⟨10.1039/c3cs60129c⟩
Journal articles hal-01460447v1

A bola-phospholipid containing tetrafluorophenylazido chromophore as a promising lipid probe for biomembrane photolabeling studies

Y. Xia , K. Sengupta , A. Maggiani , F. Qu , Ling Peng
Organic & Biomolecular Chemistry, 2013, 11, pp.5000-5005
Journal articles hal-00914728v1

Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function

X. Liu , Y. Wang , E. Laurini , P. Posocco , H. Chen
Organic Letters, 2013, 15, pp.4664-4665
Journal articles hal-00914747v1

19F NMR: a valuable tool for studying biological events

H. Chen , S. Viel , F. Ziarelli , Ling Peng
Chemical Society Reviews, 2013, 42, pp.7971-82. ⟨10.1039/c3cs60129c⟩
Journal articles hal-00914745v1

Photoactivatable lipid probes to study biomembranes using photoaffinity labeling

Y. Xia , Ling Peng
Chemical Reviews, 2013, 113, pp.7880-7929
Journal articles hal-00914750v1

Conformational changes of small PAMAM dendrimers as a function of their charge state: a combined electrospray mass spectrometry, traveling-wave ion mobility and molecular modeling study

A. Tintaru , S. Pricl , L. Denbigh , X. Liu , Ling Peng
International Journal of Mass Spectrometry, 2013, 354-355, pp.235-241
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Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing

P. Posocco , X. Liu , E. Laurini , D. Marson , C. Chen
Molecular Pharmaceutics, 2013, 10, pp.3262-3273
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Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer

Y-F. Chen , Z. Dong , Y. Xia , J. Tang , Ling Peng
Cancer Science, 2013, 104 (12), pp.1683-1689. ⟨10.1111/cas.12277⟩
Journal articles hal-00919578v1

C-S coupling using a mixed-ligand Pd catalyst: a highly effective strategy for synthesizing arylthio-substituted heterocycles

M. Cong , Y. Fan , J-L. Raimundo , Y. Xia , Yehan Liu
Chemistry - A European Journal, 2013, 19, pp.17267-17272
Journal articles hal-00919577v1
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Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells

M-F. Lang , S. Yang , C. Zhao , G. Sun , K. Murai
PLoS ONE, 2012, 7 (4), pp.e36248
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Targeting heat shock factor I with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer

Y. Xia , Yehan Liu , P. Rocchi , M. Wang , Y. Fan
Cancer Letters, 2012, 318, pp.145-153
Journal articles hal-00697518v1

Rationalizing the F...S interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid

Yi Xia , Stéphane Viel , Yang Wang , Fabio Ziarelli , Erik Laurini
Chemical Communications, 2012, 48 (36), pp.4284--4286. ⟨10.1039/c2cc18147a⟩
Journal articles hal-01460422v1

An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo

T. Yu , X. Liu , A-L. Bolcato-Bellemin , Y. Wang , C. Liu
Angewandte Chemie International Edition, 2012, 51, pp.8478-8484
Journal articles hal-00773462v1

HR-MAS NMR to investigate protein-ligand binding events in mass-limited samples

F. Ziarelli , Ling Peng , C-C. Zhang , S. Viel
Journal of Pharmaceutical and Biomedical Analysis, 2012, 59, pp.13-17
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The seemingly trivial yet challenging synthesis of poly(aminoester) dendrimers

Y. Wang , G. Quélever , Ling Peng
Current Medicinal Chemistry, 2012, 19, pp.5011
Journal articles hal-00773476v1

Targeting heat shock response pathway to treat pancreatic cancer

Y. Xia , P. Rocchi , J. Iovanna , Ling Peng
Drug Discovery Today, 2012, 17, pp.35-43
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High resolution magic angle spinning NMR to investigate ligand-receptor binding events for mass-limited samples in liquids

Fabio Ziarelli , Ling Peng , Cheng-Cai Zhang , Stéphane Viel
Journal of Pharmaceutical and Biomedical Analysis, 2012, 59, pp.13--17. ⟨10.1016/j.jpba.2011.10.006⟩
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Dendrimers as non-viral vectors for siRNA delivery

X. Liu , P. Rocchi , Ling Peng
New Journal of Chemistry, 2012, 36, pp.256-263
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Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer

X. Liu , C. Liu , E. Laurini , P. Posocco , S. Pricl
Molecular Pharmaceutics, 2012, 9 (3), pp.470-481
Journal articles hal-00697517v1

An efficient mixed-ligand Pd catalytic system to promote C-N coupling for the synthesis of N-arylaminotriazole nucleosides

Y. Fan , X. Xia , J. Tang , F. Ziarelli , F. Qu
Chemistry - A European Journal, 2012, 18, pp.2221-2225
Journal articles hal-00696853v1

A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity

Y. Xia , M. Wang , O. Demaria , J. Tang , P. Rocchi
Journal of Medicinal Chemistry, 2012, 55 (11), pp.5642-5646. ⟨10.1021/jm300534u⟩
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Rationally designed structurally flexible PAMAM dendrimers as efficient vectors for DNA transfection in vitro and in vivo to mouse thymus

X. Liu , J. Wu , M. Yamine , J. Zhou , P. Posocco
Bioconjugate Chemistry, 2011, 22, pp.2461-2473
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Photoactivatable phospholipids bearing tetrafluorophenylazido chromophores exhibit unprecedented protonation state - dependent 19F-NMR signals

Y. Xia , F. Qu , A. Maggiani , K. Sengupta , C. Liu
Organic Letters, 2011, 13, pp.4248-4251
Journal articles hal-00624856v1

Bitriazolyl acyclonucleosides synthesized via Huisgen reaction using internal alkynes show antiviral activity against tobacco mosaic virus

M. Wang , R. Zhu , Z. Fan , Y. Fu , L. Feng
Bioorganic and Medicinal Chemistry Letters, 2011, 21, pp.354-357
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Structurally Flexible Triethanolamine Core PAMAM Dendrimers Are Effective Nanovectors for DNA Transfection in Vitro and in Vivo to the Mouse Thymus

Xiaoxuan Liu , Jiangyu Wu , Miriam Yammine , Jiehua Zhou , Paola Posocco
Bioconjugate Chemistry, 2011, 22 (12), pp.2461--2473. ⟨10.1021/bc200275g⟩
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2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria

X.J. Liu , H. Chen , E. Laurini , Y. Wang , V. Dal Col
Organic Letters, 2011, 13 (11), pp.2924-2927. ⟨10.1021/ol2009544⟩
Journal articles hal-00624846v1

Systemic administration of dendrimer-siRNA complexes efficiently suppresses HIV-1 infection

J. Zhou , P. Neff , X. Liu , J. Zhang , H. Li
Molecular Therapy, 2011, 19, pp.2228-2238
Journal articles hal-00696834v1

Active-Targeted Nanotherapy Strategies for Prostate Cancer

M. Katsogiannou , Ling Peng , C. Catapano , P. Rocchi
Current Cancer Drug Targets, 2011, 11, pp.954-965
Journal articles hal-00696828v1

Electrospray tandem mass spectrometry of poly(amino)ester dendrimers: dissociation rules and structural characterization of defective molecules

A. Tintaru , C. Chendo , V. Monnier , C. Bouillon , G. Quelever
International Journal of Mass Spectrometry, 2011, 308, pp.56-64. ⟨10.1016/j.ijms.2011.07.021⟩
Journal articles hal-00696829v1

Synthesis of Poly(amino)ester Dendrimers via Active Cyanomethyl Ester Intermediates

C. Bouillon , A. Tintaru , V. Monnier , L. Charles , G. Quelever
Journal of Organic Chemistry, 2010, 75, pp.8685-8688
Journal articles hal-00566380v1

Triazole Nucleoside Derivatives Bearing Aryl Functionalities on the Nucleobases Show Antiviral and Anticancer Activity

Y. Xia , F. Qu , Ling Peng
Mini Reviews in Medicinal Chemistry / Mini-Reviews in Medicinal Chemistry, 2010, 10 (9), pp.806-821
Journal articles hal-00524518v1

Ligand-Mediated Highly Effective and Selective C-N Coupling for Synthesizing Bioactive N-Aryltriazole Acyclonucleosides

Y. Fan , Y. Xia , J. Tang , P. Rocchi , F. Qu
Organic Letters, 2010, 12 (24), pp.5712-5715
Journal articles hal-00566383v1

S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus

Yehan Liu , Y. Xia , W. Li , M. Cong , A. Maggiani
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (12), pp.3610-3613
Journal articles hal-00523863v1

Novel triazole nucleoside analogs with anticancer activity

M. Wang , Y. Xia , F. Qu , Ling Peng
Chinese Journal of Medicinal Chemistry, 2010, 20 (5), pp.362
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N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer

Yehan Liu , Y. Xia , Y. Fan , A. Maggiani , P. Rocchi
Bioorganic and Medicinal Chemistry Letters, 2010, 20, pp.2503-2507
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Structural characterization of poly(amino)ester dendrimers and related impurities by electrospray tandem mass spectrometry

A. Tintaru , V. Monnier , C. Bouillon , R. Giordanengo , Ling Peng
Rapid Communications in Mass Spectrometry, 2010, 24, pp.2207-2216
Journal articles hal-00566381v1

A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells

M.H. Wang , Y. Xia , Y.T. Fan , P. Rocchi , F.Q. Qu
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (20), pp.5979-5983. ⟨10.1016/j.bmcl.2010.08.093⟩
Journal articles hal-00566366v1

Cu-mediated Selective N-arylation of Aminotriazole Acyclonucleosides

W. Li , Y. Fan , P. Rocchi , R. Zhu , F. Qu
Helvetica Chimica Acta, 2009, 92, pp.1503-1513
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PAMAM dendrimer mediated siRNA delivery to target heat-shock protein 27 and produce potent antiproliferation effect on prostate cancer PC-3 cells

X. Liu , P. Rocci , F. Qu , S. Zheng , Z. Liang
ChemMedChem, 2009, 4, pp.1302-1310
Journal articles hal-00440698v1

Discovery of novel arylethynyltriazole Ribonucleosides with selective and effective antiviral and anti-proliferative activity

J. Wan , Y. Xia , Yehan Liu , M. Wang , P. Rocchi
Journal of Medicinal Chemistry, 2009, 52, pp.1144-1155
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Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer

Y. Xia , Yehan Liu , J. Wan , M. Wang , P. Rocchi
Journal of Medicinal Chemistry, 2009, 52 (19), pp.6083-6096. ⟨10.1021/jm900960v⟩
Journal articles hal-00440701v1

Complexing photolabile cholinergic ligands with synthetic and biological receptors: a dynamic survey

A. Specht , S. Loudwig , Ling Peng , M. Goeldner
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 65, pp.157-163
Journal articles hal-00440700v1

Efficient synthesis of esters containing tertiary amine functionalities via active cyanomethyl ester intermediates

C. Bouillon , G. Quéléver , Ling Peng
Tetrahedron Letters, 2009, 50 (30), pp.4346-4349
Journal articles hal-00413539v1

Bitriazolyl Acyclonucleosides with Antiviral Activity against Tobacco Mosaic Virus

W. Li , Y. Xia , Z. Fan , F. Qu , Q. Wu
Tetrahedron Letters, 2008, 49, pp.2804-2809
Journal articles hal-00303814v1

Arylethynyltriazole Acyclonucleosides Inhibit Hepatitis C Virus Replication

R. Zhu , M. Wang , Y. Xia , F. Qu , J. Neyts
Bioorganic and Medicinal Chemistry Letters, 2008, 18, pp.3321-3327
Journal articles hal-00303813v1

Direct Synthesis of 5-Aryltriazole Acyclonucleosides via Suzuki Coupling in Aqueous Solution

R. Zhu , F. Qu , G. Quelever , Ling Peng
Tetrahedron Letters, 2007, 48, pp.2389-2393
Journal articles hal-00303627v1

Palmitoylation is required for efficient Fas cell death signaling.

Krittalak Chakrabandhu , Zoltán Hérincs , Sébastien Huault , Britta Dost , Ling Peng
EMBO Journal, 2007, 26 (1), pp.209-20. ⟨10.1038/sj.emboj.7601456⟩
Journal articles hal-00165458v1

Propagation of structural deviation of poly(amido)amine fan-shape dendrimers (generations 0 to 3) characterized by MALDI and electrospray mass spectrometry

R. Giordanengo , M. Mazarin , J. Wu , Ling Peng , L. Charles
International Journal of Mass Spectrometry, 2007, 266 (1-3), pp.62-75. ⟨10.1016/j.ijms.2007.07.002⟩
Journal articles hal-00303628v1

Palmitoylation is Required for Fas to Trigger Cell Death Signaling

Z. Herincs , K. Chakrabandhu , B. Dost , Ling Peng , F. Conchonaud
EMBO Journal, 2007, 26, pp.209-220
Journal articles hal-00303625v1

Importance of Size to Charge Ratio in Construction of Stable and Uniform Nanoscale RNA/dendrimer Complexes

X.-C. Shen , J. Zhou , X. Liu , J. Wu , F. Qu
Organic & Biomolecular Chemistry, 2007, 5, pp.3674-3681
Journal articles hal-00303629v1

Synthesis of Bitriazolyl Nucleosides and Unexpectedly Different Reactivity of Azidotriazole Nucleoside Isomers in Huisgen Reaction

Y. Xia , W. Li , F. Qu , Z. Fan , X. Liu
Organic & Biomolecular Chemistry, 2007, 5, pp.1695-1701
Journal articles hal-00303626v1

PAMAM dendrimers for efficient siRNA delivery and potent gene silencing

J. Zhou , J. Wu , N. Hafdi , J.-P. Behr , P. Erbacher
Chemical Communications, 2006, 22, pp.2362-2364. ⟨10.1039/B601381C⟩
Journal articles hal-00130018v1

Heterocyst differentition and pattern formation in cyanobacteria: a chorus of signals

C.-C. Zhang , S. Laurent , S. Sakr , Ling Peng , S. Bédu
Molecular Microbiology, 2006, 59(2), pp.367-375
Journal articles hal-00067898v1

Cooperative binding and self-assembling behavior of cationic low-molecular-weight dendrons with RNA molecules

J. Zhou , J. Wu , X.X. Liu , F. Qu , M. Xiao
Organic & Biomolecular Chemistry, 2006, 4(3), pp.581-585
Journal articles hal-00067894v1

Para-Sulfonated Calixarenes Used as Synthetic Receptors for Complexing Photolabile Cholinergic Ligand

Alexandre Specht , Fabio Ziarelli , Philippe Bernard , Maurice Goeldner , Ling Peng
Helvetica Chimica Acta, 2005, 88 (10), pp.2641-2653. ⟨10.1002/hlca.200590205⟩
Journal articles hal-00129989v1