Marc FERRE

MEng French Grande Ecole, PhD Bioinformatics
34
Documents

Présentation

Marc Ferré graduated in 2002 from a French "Grande École d'Ingénieur" (graduate school of engineering, ESEO), in 2009 a PhD in Bioinformatics and in 2022 the Habilitation (“accreditation to supervise research”, Habilitation à diriger des recherches in French). Until August 2014, he was employed by the University Hospital of Angers (France) as bioinformatician through the formation of a national network coordinated by the French Department of Health (genetic study of neuromuscular and sensory pathologies, and mental retardation).

He is currently Associate Professor in Molecular Biology and Bioinformatics at the Angers Medical School.

He is also a staff member of the research team UMR CNRS 6015/INSERM 1083 — CNRS, The Centre National de la Recherche Scientifique (National Center for Scientific Research), is a government-funded research organization, under the administrative authority of France’s Ministry of Research; INSERM, the Institut national de la santé et de la recherche médicale (French National Institute of Health and Medical Research), is a public scientific and technological institute which operates under the joint authority of the French Ministry of Health and French Ministry of Research.

Research activity of Dr. Ferré has been conducted in the field of mitochondrial diseases.

He began his career by studying in silico the human mitochondrial proteome and developing a bioinformatics research strategy to identify new mitochondrial proteins on the basis of their prokaryotic origin. In parallel to this overall strategy of screening, he focused on the study of the Opa1 protein, one of the proteins associated with dominant optic atrophy, which is involved in mitochondrial fusion. Opa1, a dynamin GTPase, is involved in the remodeling of the inner mitochondrial membrane, apoptosis, maintenance of mitochondrial DNA, and energy metabolism. He finally developed an international database listing the variations of Opa1 so as to characterize its mutational spectrum. This tool was used as a complement to a multicentric clinical study involving thousands of patients with optic neuropathy. His work has led to the development of novel bioinformatics tools that should contribute to a better understanding of mitochondrial pathophysiology. He is currently focused on three axes: (1) designing and the curating clinico-biological databases of genes involved in neuro-ophthalmological diseases (ACO2, DNM1L, MFN2, NR2F1, OPA1, RTN4IP1, SPG7, SSBP1), as a member of the Global Variome (ex-Human Variome Project) since 2012 and Clinical Genome Resource (ClinGen) since 2020; (2) exceeding the current reading limits of the human mitochondrial genome sequence, via an innovative technique in which the complete double-stranded mitochondrial DNA is read directly without DNA amplification or incorporation of nucleotides; (3) analyzing the big data generated by the two previous axes, by biostatistical methods, bioinformatics and artificial intelligence, towards a Molecular Medicine approach.

He has supervised 6 theses in science and especially in medicine specializing in ophthalmology, including one ongoing supervision, with each supervision resulting in an article of which the student is first author (except one as second author).

Dr. Ferré’s h-index is 23 (i.e. 23 articles are cited more than 23 times) and he has contributed to 45 scientific articles in international peer-reviewed journals since 2004, of which 42 are original and 2 are review articles, 5 are first author (2005–2015) and 4 are last author (2011–2021), cited 1,486 times (1,402 without self-citations), for an average of 33 cites per article (data from Web of Science Core Collection).

Publications

Publications

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Genetic susceptibility to optic neuropathy in patients with alcohol use disorder

Camille Delibes , Marc Ferré , Marine Rozet , Valérie Desquiret-Dumas , Alexis Descatha et al.
Journal of Translational Medicine, 2024, 22 (1), pp.495. ⟨10.1186/s12967-024-05334-0⟩
Article dans une revue hal-04605126 v1

The top 10 most frequently involved genes in hereditary optic neuropathies in 2186 probands

Aude Rocatcher , Valérie Desquiret-Dumas , Majida Charif , Marc Ferré , Philippe Gohier et al.
Brain - A Journal of Neurology , 2023, 146 (2), pp.455-460. ⟨10.1093/brain/awac395⟩
Article dans une revue hal-04959530 v1

NR2F1 database: 112 variants and 84 patients support refining the clinical synopsis of Bosch–Boonstra–Schaaf optic atrophy syndrome

Benjamin Billiet , Patrizia Amati-Bonneau , Valérie Desquiret-Dumas , Khadidja Guehlouz , Dan Milea et al.
Human Mutation, 2022, 43 (2), pp.128-142. ⟨10.1002/humu.24305⟩
Article dans une revue hal-03861098 v1

ACO2 clinicobiological dataset with extensive phenotype ontology annotation

Khadidja Guehlouz , Thomas Foulonneau , Patrizia Amati-Bonneau , Majida Charif , Estelle Colin et al.
Scientific Data , 2021, 8 (1), pp.205. ⟨10.1038/s41597-021-00984-x⟩
Article dans une revue hal-03861114 v1
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A Plasma Metabolomic Profiling of Exudative Age-Related Macular Degeneration Showing Carnosine and Mitochondrial Deficiencies

Juan Manuel Chao de La Barca , Barnabé Rondet-Courbis , Marc Ferré , Jeanne Muller , Adrien Buisset et al.
Journal of Clinical Medicine, 2020, 9 (3), pp.631. ⟨10.3390/jcm9030631⟩
Article dans une revue hal-02543202 v1

OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database

Bastien Le Roux , Guy Lenaers , Xavier Zanlonghi , Patrizia Amati-Bonneau , Floris Chabrun et al.
Orphanet Journal of Rare Diseases, 2019, 14 (1), ⟨10.1186/s13023-019-1187-1⟩
Article dans une revue hal-02388214 v1

Deciphering exome sequencing data: Bringing mitochondrial DNA variants to light

Bastien Le Roux , Guy Lenaers , Xavier Zanlonghi , Patrizia Amati-Bonneau , Floris Chabrun et al.
Human Mutation, 2019, 40 (12), pp.2430-2443. ⟨10.1002/humu.23885⟩
Article dans une revue hal-02975361 v1

A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders

Cinzia Bocca , Judith Nzoughet , Stéphanie Leruez , Patrizia Amati-Bonneau , Marc Ferré et al.
Investigative Ophthalmology & Visual Science, 2018, 59, pp.185-195. ⟨10.1167/iovs.17-23027⟩
Article dans une revue hal-01964499 v1

Subretinal fibrosis is associated with fundus pulverulentus in pseudoxanthoma elasticum.

J Ebran , Ludovic Martin , Nastassia Navasiolava , Marc Ferré , Dan Milea et al.
Graefe's Archive for Clinical and Experimental Ophthalmology, 2018, 256, pp.699-707
Article dans une revue hal-02104309 v1

Multiethnic involvement in autosomal-dominant optic atrophy in Singapore

J Loo , S Singhal , A Rukmini , S Tow , Patrizia Amati-Bonneau et al.
Eye, 2017, 31, pp.475-480. ⟨10.1038/eye.2016.255⟩
Article dans une revue hal-02104157 v1
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Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1 delTTAG/+ Mice

Juan Manuel Chao de la Barca , Gilles Simard , Emmanuelle Sarzi , Tanguy Chaumette , Guillaume Rousseau et al.
Investigative Ophthalmology & Visual Science, 2017, 58 (2), pp.812-820. ⟨10.1167/iovs.16-21116⟩
Article dans une revue hal-01784466 v1

The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress

Juan Manuel Chao de La Barca , Gilles Simard , Patrizia Amati-Bonneau , Zainab Safiedeen , Delphine Mirebeau-Prunier et al.
Brain - A Journal of Neurology , 2016, 139 (11), pp.2864-2876. ⟨10.1093/brain/aww222⟩
Article dans une revue hal-02103390 v1

OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology

Juan Manuel Chao de La Barca , Delphine Mirebeau-Prunier , Patrizia Amati-Bonneau , Marc Ferré , Emmanuelle Sarzi et al.
Neurobiology of Disease, 2015, pp.20-26. ⟨10.1016/j.nbd.2015.08.015⟩
Article dans une revue hal-01392230 v1

Are zona pellucida genes involved in recurrent oocyte lysis observed during in vitro fertilization?

Marc Ferré , Patrizia Amati-Bonneau , C. Moriniere , Véronique Ferré-L’hotellier , S. Lemerle et al.
Journal of Assisted Reproduction and Genetics, 2014, 31 (2), pp.221 - 7. ⟨10.1007/s10815-013-0141-8⟩
Article dans une revue hal-03403940 v1

Loss-of-Function Mutations in WDR73 Are Responsible for Microcephaly and Steroid-Resistant Nephrotic Syndrome: Galloway-Mowat Syndrome

Estelle Colin , Huynh Cong , G. Mollet , Agnés Guichet , O. Gribouval et al.
American Journal of Human Genetics, 2014, 95 (6), pp.637 - 48. ⟨10.1016/j.ajhg.2014.10.011⟩
Article dans une revue hal-03404021 v1

Early-onset Behr syndrome due to compound heterozygous mutations in OPA1

Dominique Bonneau , Estelle Colin , Florine Oca , Marc Ferré , Arnaud Chevrollier et al.
Brain - A Journal of Neurology , 2014, Non spécifié. ⟨10.1093/brain/awu184⟩
Article dans une revue hal-03403967 v1
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Is ABCC6 a genuine mitochondrial protein?

Marc Ferré , Pascal Reynier , Arnaud Chevrollier , Delphine Prunier-Mirebeau , Georges Lefthériotis et al.
BMC Research Notes, 2013, 6 (1), pp.427. ⟨10.1186/1756-0500-6-427⟩
Article dans une revue inserm-00877607 v1

Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells

Valérie Desquiret-Dumas , Naïg Gueguen , Géraldine Leman , Stephanie Baron , Valerie Nivet-Antoine et al.
Journal of Biological Chemistry, 2013, 288 (51), pp.36662 - 75. ⟨10.1074/jbc.M113.466490⟩
Article dans une revue hal-03404098 v1
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Prevalence of rare mitochondrial DNA mutations in mitochondrial disorders

Sylvie Bannwarth , Vincent Procaccio , Anne-Sophie Lebre , Claude Jardel , A. Chaussenot et al.
Journal of Medical Genetics, 2013, 50 (10), pp.704 - 14. ⟨10.1136/jmedgenet-2013-101604⟩
Article dans une revue hal-03404064 v1

Sensorineural hearing loss in OPA1-linked disorders

Stéphanie Leruez , Dan Milea , Sabine Defoort-Dhellemmes , Estelle Colin , M. Crochet et al.
Brain - A Journal of Neurology , 2013, 136 (Pt 7), Non spécifié. ⟨10.1093/brain/aws340⟩
Article dans une revue hal-03404095 v1

Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function

Arnaud Chevrollier , Julien Cassereau , Marc Ferré , Jennifer Alban , Valérie Desquiret-Dumas et al.
International journal of biochemistry & cell biology, 2012, 44 (6), pp.980 - 8. ⟨10.1016/j.biocel.2012.03.006⟩
Article dans une revue istex hal-03404105 v1
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Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration.

Claire Angebault , Naïg Gueguen , Valérie Desquiret-Dumas , Arnaud Chevrollier , Virginie Guillet et al.
BMC Research Notes, 2011, 4 (1), pp.557. ⟨10.1186/1756-0500-4-557⟩
Article dans une revue inserm-00673659 v1
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A locus-specific database for mutations in GDAP1 allows analysis of genotype-phenotype correlations in Charcot-Marie-Tooth diseases type 4A and 2K.

Julien Cassereau , Arnaud Chevrollier , Dominique Bonneau , Christophe Verny , Vincent Procaccio et al.
Orphanet Journal of Rare Diseases, 2011, 6 (1), pp.87. ⟨10.1186/1750-1172-6-87⟩
Article dans une revue inserm-00683147 v1

Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot–Marie–Tooth type 2A disease

Virginie Guillet , Naïg Gueguen , Christophe Verny , Marc Ferré , Chadi Homedan et al.
neurogenetics, 2010, 11 (1), pp.127 - 133. ⟨10.1007/s10048-009-0207-z⟩
Article dans une revue istex hal-03406912 v1

Les atrophies optiques héréditaires

Clarisse Scherer , Vincent Procaccio , Marc Ferré , Virginie Guillet , Pascal Reynier et al.
Revue Neurologique, 2010, 166 (12), pp.959 - 65. ⟨10.1016/j.neurol.2010.07.033⟩
Article dans une revue hal-03408477 v1

Hereditary spastic paraplegia-like disorder due to a mitochondrial ATP6 gene point mutation

Christophe Verny , Naïg Gueguen , Valérie Desquiret-Dumas , Arnaud Chevrollier , Adriana Prundean et al.
Mitochondrion, 2010, 11 (1), pp.70 - 75. ⟨10.1016/j.mito.2010.07.006⟩
Article dans une revue istex hal-03408492 v1
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OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background.

Denis Pierron , Marc Ferré , Christophe Rocher , Arnaud Chevrollier , Pascal Murail et al.
BMC Medical Genetics, 2009, 10 (1), pp.70. ⟨10.1186/1471-2350-10-70⟩
Article dans une revue inserm-00663623 v1

OPA1-associated disorders: Phenotypes and pathophysiology

Patrizia Amati-Bonneau , Dan Milea , Dominique Bonneau , Arnaud Chevrollier , Marc Ferré et al.
International Journal of Biochemistry and Cell Biology, 2009, 41 (10), pp.1855 - 1865. ⟨10.1016/j.biocel.2009.04.012⟩
Article dans une revue istex hal-03406909 v1

Mitochondrial complex I deficiency in GDAP1-related autosomal dominant Charcot-Marie-Tooth disease (CMT2K)

Julien Cassereau , Arnaud Chevrollier , Naïg Gueguen , Marie-Claire Malinge , Franck Letournel et al.
neurogenetics, 2009, 10 (2), pp.145 - 150. ⟨10.1007/s10048-008-0166-9⟩
Article dans une revue istex hal-03403277 v1

Acute and late-onset optic atrophy due to a novel OPA1 mutation leading to a mitochondrial coupling defect

Yannick Nochez , Sophie Arsene , Naïg Gueguen , Arnaud Chevrollier , Marc Ferré et al.
Molecular Vision, 2009, 15, pp.598 - 608
Article dans une revue hal-03406919 v1

Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations.

Marc Ferré , Dominique Bonneau , Dan Milea , Arnaud Chevrollier , Christophe Verny et al.
Human Mutation, 2009, 30 (7), pp.E692-705. ⟨10.1002/humu.21025⟩
Article dans une revue inserm-00372261 v1
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Reversible optic neuropathy with OPA1 exon 5b mutation.

Karen Cornille , Dan Milea , Patrizia Amati-Bonneau , Vincent Procaccio , Lydie Zazoun et al.
Annals of Neurology, 2008, 63 (5), pp.667-71. ⟨10.1002/ana.21376⟩
Article dans une revue istex inserm-00287509 v1

Hereditary optic neuropathies share a common mitochondrial coupling defect.

Arnaud Chevrollier , Virginie Guillet , Dominique Loiseau , Naïg Gueguen , Marie-Anne Pou de Crescenzo et al.
Annals of Neurology, 2008, 63 (6), pp.794-8. ⟨10.1002/ana.21385⟩
Article dans une revue istex hal-00282865 v1