Marc Poirot

Directeur de l'équipe INOV au Centre de Recherches en Cancérologie de Toulouse Directeur de recherche à l'Inserm
235
Documents

Domaines de recherche

Chimie thérapeutique Sciences du Vivant [q-bio] Biochimie [q-bio.BM] Cancer Sciences pharmaceutiques Médicaments

Compétences

chimie organique chimie médicinale chimie métabolique radiochimie biochimie pharmacologie enzymologie réceptorologie biologie cellulaire differenciation cellulaire autophagie mort cellulaire études précliniques métabolisme du cholestérol oxystérols oncostérone dendrogénines

Publications

Publications

Cholesterol and Cancer: Discovery of the 5,6-Epoxycholestanol Metabolic Pathway, a Metabolic Link to Breast Cancer

M Poirot
IARC Distinguished Speaker Series, CIRC, OMS, Apr 2025, Lyon, France
Communication dans un congrès inserm-05029128 v1

Oxysterols

M Poirot , Sandrine Silvente-Poirot
Toulouse school of lipids, Inserm, Feb 2024, Toulouse, France
Communication dans un congrès inserm-05029054 v1

Cholesterol and cancer

M Poirot
WebiNacre, réseau NaCRE, Jul 2024, Paris ( virtual ), France
Communication dans un congrès inserm-05029268 v1

Recent discoveries on the cholesterol metabolic pathway: the 5,6-epoxycholesterol branch, dendrogenins and oncosterone

M Poirot
Lipid Maps webinar, Lipid Maps, Mar 2023, Cardiff (Wales), United Kingdom
Communication dans un congrès inserm-05029110 v1

The biological importance of the C5-C6 double bond of cholesterol

M Poirot
GERLI 18th LIPIDOMICS MEETING, GERLI, Oct 2023, Paris, France
Communication dans un congrès inserm-05029056 v1

Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles

M Poirot
EVClub, the International society for extracellular vesicles (ISEV), May 2023, Baltimore (MD), United States
Communication dans un congrès inserm-05029103 v1

Relations entre alimentation et incidence sur els maladies dégénératives : cas du cholestérol

Marc Poirot
WebiNACRe N°11 : Cholestérol et cancers, NACRe, Jun 2024, Web Conference, France
Communication dans un congrès inserm-04774214 v1

The oxysterol dendrogenin A increases the activation of migratory dendritic cells by acting through the LXRβ.

Julio Buñay , Laly Pucheu , Silia Ayadi , Michel Record , Philippe de Medina et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029673 v1

Metabolic switching from tumor promoter activities of oncosterone and 27-hydroxycholesterol to 27-hydroxy-oncosterone with antiproliferative properties

Silia Ayadi , Silvia Friedrichs , Regis Soulès , Laly Pucheu , Dieter Lütjohann et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029635 v1

Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate

Philippe de Medina , Silia Ayadi , Regis Soules , Bruno Payre , Sandrine Rup-Jacques et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029639 v1

The 5,6-epoxycholesterol pathway: a generator of highly bioactive oxysterols

M Poirot
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029092 v1

Biochemical and structural evidences that the human glutathion S-transferase A1 catalyzes the biosynthesis of dendrogenins.

Silia Ayadi , Georges Ndikoum-Matip , Philippe de Medina , Regis Soules , Virginie Nahoum et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029665 v1

Discovery of a new metabolic branch on the cholesterol pathway: importance in cancers and other diseases

M Poirot , Sandrine Silvente-Poirot
Smith-Lemli-Opitz Conferences, SLO foundation, Jun 2023, Seattle, United States
Communication dans un congrès inserm-05029087 v1

Relations entre alimentation et incidence sur les maladies dégénératives

M Poirot
La recherche s'intéresse à mon assiette, réseau NaCRE, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05030211 v1

Synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT/SOAT inhibitors as anticancer agents

Farid Khallouki , M Poirot , Stéphanie Caze-Subra , Kerstin Bystricky , Sandrine Silvente-Poirot et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029726 v1

Combined OCDO/DDA extraction and quantification method for a fast and accurate HPLC-MS analysis

Regis Soules , Philippe de Medina , Silia Ayadi , Étienne Chatelut , Sandrine Silvente-Poirot et al.
12th ENOR symposium, Importance of Oxysterols in Nutrition, Cancer, and Other Degenerative Diseases, ENOR, Sep 2023, Toulouse, France
Communication dans un congrès inserm-05029741 v1

Characterization of a new branch in the cholesterol pathway centered on cholesterol-5,6-epoxides: the story of dendrogenins and oncosterone discoveries

M Poirot
AOCS annual meeting, AOCS, Apr 2023, Denver, United States
Communication dans un congrès inserm-05029107 v1

The 5,6-epoxycholesterol metabolic branch: possible involvement in aging and degenerative diseases

M Poirot , Sandrine Silvente-Poirot
invited conference, Bruce D Hammock, Jan 2023, Davis (virtual conference), United States
Communication dans un congrès inserm-05029116 v1

Definition of the biological importance of the 5,6-epoxy-cholesterol branch on the cholesterol pathway: a generator of new classes of bioactive lipids

M Poirot
lipidomics special interest group conferences, British mass spectrometry society, Oct 2022, Cambridge (Angleterre), United Kingdom
Communication dans un congrès inserm-05029122 v1

GSTA1-1 is a multifunctional enzyme involved in 5,6α-epoxycholesterol conjugation with biological nucleophiles

Silia Ayadi , Georges Ndikoum-Matip , Philippe de Medina , Virginie Nahoum , Laurent Maveyraud et al.
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029750 v1

A combined OCDO/DDA extraction and quantification method for a fast and accurate determination of a carcinogenic metabolic deregulation in patients

Regis Soules , Étienne Chatelut , Sandrine Silvente-Poirot , M Poirot , Ben Allal
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029775 v1

Reprogramming tumor cells with the oxysterol, dendrogenin A, to release immunogenic anti-tumor small extracellular vesicles enriched in exosomes.

Julio Buñay , Michel Record , Laly Pucheu , M Poirot , Philippe de Medina et al.
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029772 v1

Comparative Studies on the metabolism of 5,6-epoxycholesterol, cholestane-3β,5α,6β-triol and Oncosterone in the cancer cell lines MCF-7, MDA-MB-231 and HEPG2.

Philippe de Medina , Silia Ayadi , Dieter Lütjohann , Sandrine Silvente-Poirot , M Poirot
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029763 v1

Chemical synthesis and biological properties of cholestane-5α,6β-diol-3-sulfonate, a non-hydrolyzable analogue of cholestane-5α,6β-diol-3-O-sulfate

Philippe de Medina , Mohammad Samadi , Silia Ayadi , Sandrine Rup-Jacques , Regis Soules et al.
11th ENOR symposium, ENOR, Sep 2022, Oslo, Norway
Communication dans un congrès inserm-05029757 v1

New targeting in oxysterol metabolism for triple negative breast cancer therapy.

Khadijetou Diallo , Philippe de Medina , Regis Soules , Laly Pucheu , Arnaud Mallinger et al.
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029825 v1

Inhibition of oncosterone biosynthesis as a new pharmacological anticancer strategy in breast cancer.

Philippe de Medina , Rabea Bartölke , Regis Soules , Sandrine Silvente-Poirot , M Poirot
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029843 v1

Characterization of a cholesterol metabolic switch controlling breast carcinogenesis

M Poirot , Sandrine Silvente-Poirot
10th ENOR annual symposium, ENOR, Sep 2021, Oslo / Virtual, Norway
Communication dans un congrès inserm-05029135 v1

Side chain hydroxylation of cholestane-3β,5α,6β-triol and Oncosterone lead to the production of new endogenous oxysterols potentially involved in breast cancer development.

Tifany Lalande , Regis Soules , Sandrine Silvente-Poirot , Philippe de Medina , M Poirot
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029836 v1

Characterization of a cholesterol metabolic switch controlling breast carcinogenesis

Philippe de Medina , Silia Ayadi , Emmanuel Noguer , Lisa Barrett , Regis Soules et al.
10th ENOR Symposium – Web Meeting, ENOR, Sep 2021, Web Conf, United Kingdom
Communication dans un congrès inserm-05029820 v1

Biochemical and pharmacological characterization of the enzyme responsible for the biosynthesis of 6-oxo-cholestan-3β-5α-diol (OCDO), a carcinogenic oxysterol

M Poirot , Sandrine Silvente-Poirot
9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edimburgh, Scotland, United Kingdom
Communication dans un congrès inserm-05029141 v1

Biochemical and pharmacological characterization of the enzyme responsible for the biosynthesis of 6-oxo-cholestan-3β-5α-diol (OCDO), a carcinogenic oxysterol

M Poirot , Sandrine Silvente-Poirot
9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourg, Ecosse, United Kingdom
Communication dans un congrès inserm-05029857 v1

Discovery of the tumor suppressor metabolite dendrogenin A and applications to cancer treatment

M Poirot
invited conference, Alex Odermatt, Apr 2019, Basel (CH), Switzerland
Communication dans un congrès inserm-05029259 v1

An oxysterol oncometabolite and glucocorticoid receptor signaling in triple negative breast cancer cell proliferation.

Arnaud Mallinger , Khadijetou Diallo , M Poirot , Sandrine Silvente-Poirot
9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourgh (Scotland), United Kingdom
Communication dans un congrès inserm-05029849 v1

Design, synthesis and cellular evaluation of new bi-specific estrogen receptor modulators and ACAT inhibitors as anticancer agents

Farid Khallouki , Guillaume Amouroux , Stéphanie Caze-Subra , Kerstin Bystricky , Patrick Balaguer et al.
9th ENOR SYMPOSIUM, Metabolism and Oxysterols: Therapeutics for Lifelong Health, ENOR, Sep 2019, Edinbourg, Ecosse, United Kingdom
Communication dans un congrès inserm-05029855 v1

Abstract 5238: Characterization of the enzyme generating the cholesterol metabolite and tumor suppressor dendrogenin A in the breast and its deregulations in breast cancer

Marc Poirot , Emmanuel Noguer , Florence Dalenc , Regis Soules , Lisa Barrett et al.
Annual Meeting of the American-Association-for-Cancer-Research (AACR), AACR, Apr 2018, Chicago (IL), United States. pp.5238-5238, ⟨10.1158/1538-7445.AM2018-5238⟩
Communication dans un congrès inserm-04774164 v1

Abstract P3-05-12: Circulating oxysterol metabolites as potential new surrogate markers for hormonotherapy in patients with hormone receptor-positive breast cancer? A pilot study

Florence Dalenc , Luggi Iuliano , Thomas Filleron , Maud Voisin , Henri Roché et al.
37th Annual CTRC-AACR San Antonio Breast Cancer Symposium, AACR, Dec 2014, San antonio, Texas, United States. pp.P3-05-12-P3-05-12, ⟨10.1158/1538-7445.SABCS14-P3-05-12⟩
Communication dans un congrès inserm-04774156 v1

Abstract 1165: Identification of a cholesterol onco-metabolite, promoter of tumor in breast cancers, and of the enzyme involved in its biosynthesis

Maud Voisin , Philippe de Medina , Michael Paillasse , Magali Lacroix-Triki , Florence Dalenc et al.
106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Apr 2015, PHILADELPHIA, France. pp.1165-1165, ⟨10.1158/1538-7445.AM2015-1165⟩
Communication dans un congrès inserm-04774093 v1

R167 - Oral, Club Mex-H Quantification du volume tumoral résiduel des cancers du rectum post-radiochimiothérapie par histomorphométrie quantitative

L. Ghouti , F. Courbon , Marc Poirot , R. Guimbaud , B. Pradère et al.
6es journées du Cancéropôle Grand Sud-Ouest, Cancéropôle Grand Sud-Ouest, Oct 2010, Toulouse, France. pp.S82, ⟨10.1016/S0007-4551(15)31088-2⟩
Communication dans un congrès inserm-04774147 v1

Generation of whole-body scintigraphic images with new GATE output capacities

Marie-Paule Garcia , Daphnée Villoing , Erin Mckay , Ludovic Ferrer , Henri Der Sarkissian et al.
IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), IEEE, Oct 2013, Seoul, South Korea. pp.1-3, ⟨10.1109/NSSMIC.2013.6829150⟩
Communication dans un congrès hal-01133300 v1

Abstract 938: Discovery of Dendrogenin A as the first endogenous alkylaminooxysterol present in mammals with potent cell differentiation and anticancer activity

Marc Poirot , Philippe de Medina , Michael Paillasse , Grégory Segala , Tallal Al Saati et al.
Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research, Apr 2011, ORLANDO, United States. pp.938-938, ⟨10.1158/1538-7445.AM2011-938⟩
Communication dans un congrès inserm-04774118 v1

Dendrogenins, new steroids for differentiation therapies

Marc Poirot
Summer school on medicine, Sep 2009, BARCELONA, Spain
Communication dans un congrès inserm-04774065 v1
Image document

The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases

Philippe de Medina , Silia Ayadi , Khadijetou Diallo , Julio Buñay , Laly Pucheu et al.
Implication of Oxysterols and Phytosterols in Aging and Human Diseases, 1440, Springer International Publishing, pp.149-161, 2024, Advances in Experimental Medicine and Biology, ⟨10.1007/978-3-031-43883-7_8⟩
Chapitre d'ouvrage inserm-04317348 v1
Image document

Vitamin E: an overview

Farid Khallouki , Robert Wyn Owen , Mourad Akdad , Bachir El Bouhali , Sandrine Silvente-Poirot et al.
Molecular Nutrition, Elsevier, pp.51-66, 2020, ⟨10.1016/B978-0-12-811907-5.00001-4⟩
Chapitre d'ouvrage inserm-03084874 v1

Phytosterol derivatives, and compositions comprising the same, for use as medicaments

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : EP24305827. 2024
Brevet inserm-04773991 v1

Radiotraceurs de tomographie par émission de positrons (TEP) de fluoro-oxystérols

Marc Poirot , Frédéric Courbon , Mohammad Samadi , Philippe de Medina , Sandrine Silvente-Poirot et al.
France, N° de brevet: WO2024146880A1. 2024
Brevet inserm-04773942 v1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
United States, Patent n° : US2023138400A1. 2023
Brevet inserm-04773900 v1

Fluoro-oxysterols positron emission tomography (PET) radiotracers

Marc Poirot , Frédéric Courbon , Mohammad Samadi , Philippe de Medina , Sandrine Silvente-Poirot et al.
France, Patent n° : European patent, EP23305003.8. 2023
Brevet hal-04842549 v1

PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Canada, N° de brevet: CA2856609C. 2021
Brevet inserm-04772970 v1

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REPROGRAMING IMMUNE ENVIRONMENT IN A SUBJECT IN NEED THEREOF

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
United States, Patent n° : US2020016177A1. 2020
Brevet inserm-04773893 v1

MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
France, N° de brevet: EP3515453A1. 2019
Brevet inserm-04773879 v1

Dendrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
España, N° de brevet: ES2734425T3. 2019
Brevet inserm-04773729 v1

Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, Patent n° : US10188666B2. 2019
Brevet inserm-04773745 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3272350B1. 2019
Brevet inserm-04773717 v1

Endrogenina A y agentes antineoplásicos para el tratamiento de tumores quimiosensibles o quimiorresistentes

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
España, N° de brevet: ES2656913T3. 2018
Brevet inserm-04773723 v1

METHODS OF DIAGNOSING AND TREATING CANCER

Marc Poirot , Sandrine Silvente-Poirot
United States, Patent n° : US2018231556A1. 2018
Brevet inserm-04773847 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3272350A1. 2018
Brevet inserm-04773712 v1

MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES PERMETTANT LA REPROGRAMMATION DE L'ENVIRONNEMENT IMMUNITAIRE CHEZ UN SUJET EN AYANT BESOIN

Marc Poirot , Julie Leignadier , Philippe de Medina , Michel Record , Sandrine Silvente-Poirot
France, N° de brevet: WO2018055080A1. 2018
Brevet inserm-04773906 v1

甾醇衍生物的制备方法

Marc Poirot , Michaël Paillasse , Philippe de Medina , Sandrine Silvente-Poirot
China, Patent n° : CN104039807B. 2018
Brevet inserm-04773150 v1

癌の診断法及びデンドロゲニンAを用いての処置に対する癌の応答を予測する方法

Marc Poirot , Emmanuel Noguer , Sandrine Silvente-Poirot
France, Patent n° : JP2018503064A. 2018
Brevet inserm-04773867 v1

Sales de adición de ácidos de 5alfa-hidroxi-6beta-[2-(1H-imidazol-4-il)etilamino]colestan-3beta-ol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Francia, N° de brevet: ES2650914T3. 2018
Brevet inserm-04772765 v1

Proceso para la preparación de derivados de esterol

Marc Poirot , Michaël Paillasse , Philippe de Medina , Sandrine Silvente-Poirot
España, N° de brevet: ES2613753T3. 2017
Brevet inserm-04773222 v1

MÉTHODES DE DIAGNOSTIC DU CANCER ET DE PRÉDICTION DE RÉPONSE DU CANCER À UN TRAITEMENT À LA DENDROGÉNINE

Marc Poirot , Emmanuel Noguer , Sandrine Silvente-Poirot
France, N° de brevet: EP3221467A1. 2017
Brevet inserm-04773861 v1

processo para o preparo de derivados de esterol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Brazil, Patent n° : BR112014012458A2. 2017
Brevet inserm-04772921 v1

METHODS OF DIAGNOSING AND TREATING CANCER

Marc Poirot , Sandrine Silvente-Poirot
United States, Patent n° : US2017234881A1. 2017
Brevet inserm-04773829 v1

METHODS OF DIAGNOSING CANCER AND OF PREDICTING RESPONSE OF CANCER TO DENDROGENIN A TREATMENT

Marc Poirot , Sandrine Silvente-Poirot , Emmanuel Noguer
United States, Patent n° : US2017321283A1. 2017
Brevet inserm-04773868 v1

癌を診断及び処置する方法

Marc Poirot , Sandrine Silvente-Poirot
Japan, Patent n° : JP2017527290A. 2017
Brevet inserm-04773842 v1

ACID ADDITION SALTS OF 5a-HYDROXY-6ß-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3ß-OL.

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX351610B. 2017
Brevet inserm-04772804 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Austria, Patent n° : AU2012342460B2. 2017
Brevet inserm-04772907 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3041477B1. 2017
Brevet inserm-04773704 v1

ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA -[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA -OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : EP2768841B1. 2017
Brevet inserm-04772755 v1

MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER

Marc Poirot , Sandrine Silvente-Poirot
France, N° de brevet: EP3194615A1. 2017
Brevet inserm-04773835 v1

Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : US2017176446A1. 2017
Brevet inserm-04772284 v1

ステロール誘導体の調製方法

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : JP6157492B2. 2017
Brevet inserm-04773268 v1

Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
China, Patent n° : CN105611934A. 2016
Brevet inserm-04773695 v1

METHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER

Marc Poirot , Sandrine Silvente-Poirot
Canada, N° de brevet: CA2960036A1. 2016
Brevet inserm-04773830 v1

MÉTHODES DE DIAGNOSTIC DU CANCER ET DE PRÉDICTION DE RÉPONSE DU CANCER À UN TRAITEMENT À LA DENDROGÉNINE

Marc Poirot , Sandrine Silvente-Poirot , Emmanuel Noguer
France, N° de brevet: WO2016079057A1. 2016
Brevet inserm-04773871 v1

METHODES DE DIAGNOSTIC DU CANCER ET DE PREDICTION DE REPONSE DU CANCER A UN TRAITEMENT A LA DENDROGENINE

Marc Poirot , Emmanuel Noguer , Sandrine Silvente-Poirot
Canada, N° de brevet: CA2968002A1. 2016
Brevet inserm-04773858 v1

PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: EP2782923B1. 2016
Brevet inserm-04773181 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX343787B. 2016
Brevet inserm-04773308 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US9447141B2. 2016
Brevet inserm-04773449 v1

MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER

Marc Poirot , Sandrine Silvente-Poirot
France, N° de brevet: WO2016034742A1. 2016
Brevet inserm-04773852 v1

MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: EP2446276B9. 2016
Brevet inserm-04772270 v1

化学療法感受性又は化学療法抵抗性腫瘍の治療のためのデンドロゲニンA及び抗腫瘍薬

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
Japan, Patent n° : JP2016532709A. 2016
Brevet inserm-04773739 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASTIQUES POUR LE TRAITEMENT DES TUMEURS CHIMIOSENSITIVES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: EP3041477A1. 2016
Brevet inserm-04773700 v1

Dendrogenin A and antineoplastic agents for the treatment of chemosensitive or chemoresistant tumors

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
Australia, Patent n° : AU2014317117A1. 2016
Brevet inserm-04773484 v1

DENDROGENIN A AND ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CHEMOSENSITIVE OR CHEMORESISTANT TUMORS

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
United States, Patent n° : US2016193233A1. 2016
Brevet inserm-04773751 v1

METHODS FOR DETERMINING THE ONCOGENIC CONDITION OF CELL, USES THEREOF, AND METHODS FOR TREATING CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : PL2446276T3. 2015
Brevet inserm-04772282 v1

КИСЛОТНО-АДДИТИВНЫЕ СОЛИ 5α-ГИДРОКСИ-6β-[2-(1H-ИМИДАЗОЛ-4-ИЛ)ЭТИЛАМИНО]ХОЛЕСТАН-3β-ОЛА

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Russia, Patent n° : RU2014119929A. 2015
Brevet inserm-04772821 v1

DENDROGÉNINE A ET AGENTS ANTINÉOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORÉSISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
France, N° de brevet: WO2015032838A1. 2015
Brevet inserm-04773825 v1

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ СТЕРИНА

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : RU2014125435A. 2015
Brevet inserm-04773440 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
India, Patent n° : IN976MUN2014A. 2015
Brevet inserm-04773233 v1

DENDROGENINE A ET AGENTS ANTINEOPLASIQUES POUR LE TRAITEMENT DE TUMEURS CHIMIOSENSIBLES OU CHIMIORESISTANTES

Marc Poirot , Philippe de Medina , Michaël Paillasse , Christian Récher , Sandrine Silvente-Poirot
Canada, N° de brevet: CA2922715A1. 2015
Brevet inserm-04773546 v1

ステロール誘導体の調製方法

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Japan, Patent n° : JP2015502934A. 2015
Brevet inserm-04773250 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
South Africa, Patent n° : ZA201403736B. 2015
Brevet inserm-04773467 v1

ACID ADDITION SALTS OF 5ALFA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYL AMINO]CHOLESTAN-3BETA-OL.

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX2014004744A. 2015
Brevet inserm-04772791 v1

Aminoalkylsterol compounds with antitumoral and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : US8957055B2. 2015
Brevet inserm-04772244 v1

細胞の腫瘍形成状態を決定する方法、その使用、及び癌の治療方法

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : JP5765587B2. 2015
Brevet inserm-04772280 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES.

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX2014006303A. 2014
Brevet inserm-04773292 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US2014309417A1. 2014
Brevet inserm-04773447 v1

ACID ADDITION SALTS OF 5α-HYDROXY-6β-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3β-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
South Korea, Patent n° : KR20140083014A. 2014
Brevet inserm-04772786 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US2014309417A1. 2014
Brevet inserm-04772885 v1

5α−ヒドロキシ−6β−[2−(1H−イミダゾール−4−イル)エチルアミノ]コレスタン−3β−オールの酸付加塩

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Japan, Patent n° : JP2014530245A. 2014
Brevet inserm-04772775 v1

Acid addition salts of 5alpha-hydroxy-6beta-[2-(1H-imidazol-4-yl)ethylamino]cholestan-3beta-ol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : AU2012324980A1. 2014
Brevet inserm-04772297 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Mexico, Patent n° : MX2014006303A. 2014
Brevet inserm-04773301 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
China, Patent n° : CN104039807A. 2014
Brevet inserm-04773135 v1

ACID ADDITION SALTS OF 5ALPHA-HYDROXY-6BETA-[2-(1H-IMIDAZOL-4-YL)ETHYLAMINO]CHOLESTAN-3BETA-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
United States, Patent n° : US2014274984A1. 2014
Brevet inserm-04772841 v1

PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE STÉROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: EP2782923A1. 2014
Brevet inserm-04773167 v1

Acid addition salts of 5[alpha]-hydroxy-6[beta]-[2-(1h-imidazol-4-yl)ethylamino]cholestan-3[beta]-ol

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : CN103958541A. 2014
Brevet inserm-04772748 v1

Process for the preparation of sterol derivatives

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Austria, Patent n° : AU2012342460A1. 2014
Brevet inserm-04772895 v1

Methods for determining the oncogenic condition of cell, uses thereof, and methods for treating cancer

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : CN102498404B. 2014
Brevet inserm-04772266 v1

PROCESS FOR THE PREPARATION OF STEROL DERIVATES

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
South Korea, Patent n° : KR20140098131A. 2014
Brevet inserm-04773285 v1

PROCÉDÉ POUR LA PRÉPARATION DE DÉRIVÉS DE STÉROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: WO2013076257A1. 2013
Brevet inserm-04773460 v1

PROCEDE POUR LA PREPARATION DE DERIVES DE STEROL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
Canada, N° de brevet: CA2856609A1. 2013
Brevet inserm-04772952 v1

SELS D'ADDITION D'ACIDE DE 5Alpha-HYDROXY-6Beta-[2-(1H-IMIDAZOL-4-YL)- ÉTHYLAMINO]CHOLESTAN-3Beta-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: WO2013057148A1. 2013
Brevet inserm-04772848 v1

SELS D'ADDITION D'ACIDE DE 5'-HYDROXY-6'-[2-(1H-IMIDAZOL-4-YL)- ETHYLAMINO]CHOLESTAN-3'-OL

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: CA2852622A1. 2013
Brevet inserm-04772735 v1

Aminoalkylsterol compounds with antitumoral and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : US8524694B2. 2013
Brevet inserm-04772236 v1

COMPOUND INDUCING LBPA ACCUMULATION FOR INHIBITING CELL-TO-CELL TRANSMISSION OF HIV

Marc Poirot , Michel Record , Jacques Izopet , Sabine Chapuy-Regaud
France, Patent n° : WO2012055814A1. 2012
Brevet inserm-04772290 v1

DETECTION DE L'ETAT ONCOGENE DE CELLULES HUMAINES OU DE MAMMIFERES PAR PRESENCE D'UN MARQUEUR ET EVALUATION DE L'ACTIVITE D'UN MEDICAMENT PAR DOSAGE DUDIT MARQUEUR

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : FR2947340B1. 2011
Brevet inserm-04772274 v1

Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : US7947668B2. 2011
Brevet inserm-04772230 v1

METHODES POUR DETERMINER L'ETAT ONCOGENIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET METHODES POUR TRAITER LE CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, Patent n° : CA2766011A1. 2010
Brevet inserm-04772259 v1

MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER

Marc Poirot , Sandrine Silvente-Poirot , Michaël Paillasse , Philippe de Medina
France, N° de brevet: WO2010149941A1. 2010
Brevet inserm-04772286 v1

Aminoalkylsterol compounds having antitumor and neuroprotective activity

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : JP4601297B2. 2010
Brevet inserm-04772227 v1

AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : EP1497309B1. 2009
Brevet inserm-04772209 v1

AMINOALKYLSTERINVERBINDUNGEN MIT ANTI-KREBS UND NEUROPROTEKTIVER AKTIVITÄT

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : ATE420888T1. 2009
Brevet inserm-04772185 v1

COMPUESTOS AMINOALQUILESTEROLES CON ACTIVIDAD ANTITUMORAL Y NEUROPROTECTORA

Marc Poirot , Sandrine Silvente-Poirot , Philippe de Medina
France, Patent n° : ES2321287T3. 2009
Brevet inserm-04772212 v1

Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity

Philippe de Medina , Sandrine Silvente-Poirot , Marc Poirot
France, Patent n° : AU2003262422B8. 2008
Brevet inserm-04772197 v1

COMPOSES AMINOALKYLSTEROLES AVEC ACTIVITE ANTI-TUMEUR ET NEUROPROTECTRICE

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : EP1497309A2. 2005
Brevet inserm-04772177 v1

NEW STILBENE DERIVATIVES AND THEIR USE AS ARYL HYDROCARBON RECEPTOR LIGAND ANTAGONISTICS

Jean-François Savouret , Marc Poirot , Philippe de Medina , Robert F Casper
France, Patent n° : EP1418164A1. 2004
Brevet inserm-04772124 v1

STEROL DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND MEDICAMENTS COMPRISING SAME

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : WO03089449A2. 2003
Brevet inserm-04772249 v1

Nouveaux derivés de stilbène et leur utilisation en tant que antagonistes des ligands du recepteur des arylhydrocarbures

Robert F Casper , Jean-François Savouret , Marc Poirot , Philippe de Medina
France, Patent n° : EP03773372A. 2003
Brevet inserm-04772141 v1

AMINOALKYL STEROL COMPOUNDS HAVING AN ANTI-TUMORAL AND NEUROPROTECTIVE ACTIVITY

Marc Poirot , Philippe de Medina , Sandrine Silvente-Poirot
France, Patent n° : CA2481561A1. 2003
Brevet inserm-04772202 v1

DERIVES DE STEROLS, LEUR PROCEDE DE PREPARATION ET MEDICAMENTS LES COMPORTANT

Marc Poirot , Philippe de Medina
France, N° de brevet: FR0204912A. 2002
Brevet inserm-04772155 v1
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Current advances in phytosterol free forms and esters: Classification, biosynthesis, chemistry, and detection

Farid Khallouki , Wafa Zennouhi , Lhoussain Hajji , Mohamed Bourhia , Laila Benbacer et al.
Steroids, 2024, 212, pp.109520. ⟨10.1016/j.steroids.2024.109520⟩
Article dans une revue inserm-04772028 v2
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Editorial: Lipids, lipid oxidation, and cancer: from biology to therapeutics

Sergio P Bydlowski , Marc Poirot
Frontiers in Oncology, 2024, 14, pp.1414992. ⟨10.3389/fonc.2024.1414992⟩
Article dans une revue inserm-04772050 v1
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Is cholesterol a risk factor for breast cancer incidence and outcome?

Céline Ben Hassen , Caroline Goupille , Claire Vigor , Thierry Durand , Françoise Guéraud et al.
Journal of Steroid Biochemistry and Molecular Biology, 2023, 232, pp.106346. ⟨10.1016/j.jsbmb.2023.106346⟩
Article dans une revue hal-04165228 v1
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27-hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

Silia Ayadi , Silvia Friedrichs , Regis Soulès , Laly Pucheu , Dieter Lütjohann et al.
Journal of Lipid Research, In press, 64 (12), pp.100479. ⟨10.1016/j.jlr.2023.100479⟩
Article dans une revue inserm-04317313 v1
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Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate

Philippe de Medina , Silia Ayadi , Régis Soulès , Bruno Payre , Sandrine Rup-Jacques et al.
Journal of Steroid Biochemistry and Molecular Biology, 2023, 234, pp.106396. ⟨10.1016/j.jsbmb.2023.106396⟩
Article dans une revue hal-04509731 v1
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European Network for oxysterol research (ENOR): 10th ENOR symposium – Web meeting

Gérard Lizard , Marc Poirot , Luigi Iuliano
Steroids, 2023, 195, pp.109242. ⟨10.1016/j.steroids.2023.109242⟩
Article dans une revue inserm-04165320 v1
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An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management

Farid Khallouki , Lhoussain Hajji , Somayya Saber , Toufik Bouddine , Mouad Edderkaoui et al.
Journal of Personalized Medicine, 2023, 13 (5), pp.754. ⟨10.3390/jpm13050754⟩
Article dans une revue inserm-04165318 v1
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Oxysterols are potential physiological regulators of ageing

Philippe de Medina , Sandrine Silvente-Poirot , Marc Poirot
Ageing Research Reviews - ARR, 2022, 77, pp.101615. ⟨10.1016/j.arr.2022.101615⟩
Article dans une revue inserm-03629546 v1
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Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes

Philippe de Medina , Julio Bunay , Marc Poirot , Michel Record , Sandrine Silvente-Poirot
Autophagy, 2022, 19 (3), pp.1036-1038. ⟨10.1080/15548627.2022.2116175⟩
Article dans une revue inserm-03854248 v1
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Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

Michel Record , Mehdi Attia , Kevin Carayon , Laly Pucheu , Julio Bunay et al.
Journal of Extracellular Vesicles, 2022, 11 (4), pp.e12211. ⟨10.1002/jev2.12211⟩
Article dans une revue inserm-03649213 v1
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Celebrating the 10th anniversary of the creation of the European Network for Oxysterol Research (ENOR)

Gérard Lizard , Marc Poirot , Luigi Iuliano
Journal of Steroid Biochemistry and Molecular Biology, 2022, pp.106114. ⟨10.1016/j.jsbmb.2022.106114⟩
Article dans une revue inserm-03649224 v1
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Sterol metabolism and cancer

Marc Poirot
Biochemical Pharmacology, 2022, 196, pp.114843. ⟨10.1016/j.bcp.2021.114843⟩
Article dans une revue inserm-03649225 v1
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In vitro and In vivo oxidation and cleavage products of tocols: From chemical tuners to “VitaminEome” therapeutics. A narrative review

Farid Khallouki , Somayya Saber , Toufik Bouddine , Lhoussain Hajji , Bachir Elbouhali et al.
Food Bioscience, 2022, pp.101839. ⟨10.1016/j.fbio.2022.101839⟩
Article dans une revue inserm-03703644 v1
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European network for oxysterol research (ENOR): 10 th anniversary

Gérard Lizard , Marc Poirot , Luigi Iuliano
Journal of Steroid Biochemistry and Molecular Biology, 2021, 214, pp.105996. ⟨10.1016/j.jsbmb.2021.105996⟩
Article dans une revue inserm-03394448 v1
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The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets

Philippe Medina , Khadijetou Diallo , Emilie Huc‐claustre , Mehdi Attia , Régis Soulès et al.
British Journal of Pharmacology, 2021, 178 (16), pp.3248-3260. ⟨10.1111/bph.15205⟩
Article dans une revue inserm-03394464 v1
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Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: A systematic review and meta-analysis of preclinical models

Alex Websdale , Yi Kiew , Philip Chalmers , Xinyu Chen , Giorgia Cioccoloni et al.
Biochemical Pharmacology, 2021, pp.114731. ⟨10.1016/j.bcp.2021.114731⟩
Article dans une revue inserm-03394456 v1
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel Klionsky , Amal Kamal Abdel-Aziz , Sara Abdelfatah , Mahmoud Abdellatif , Asghar Abdoli et al.
Autophagy, 2021, 17 (1), pp.1-382. ⟨10.1080/15548627.2020.1797280⟩
Article dans une revue (article de synthèse) inserm-03285572 v1
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Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia

Pierre-Luc Mouchel , Nizar Serhan , Rémy Bétous , Thomas Farge , Estelle Saland et al.
Cancers, 2020, 12 (10), pp.2933. ⟨10.3390/cancers12102933⟩
Article dans une revue inserm-03084630 v1
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The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets

Philippe de Médina , Khadijetou Diallo , Emilie Huc Claustre , Mehdi Attia , Régis Soulès et al.
British Journal of Pharmacology, 2020, 178 (16), pp.3248-3260. ⟨10.22541/au.159069407.75369904⟩
Article dans une revue inserm-03086999 v1
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Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

Nizar Serhan , Pierre-Luc Mouchel , Philippe de Médina , Gregory Segala , Aurélie Mougel et al.
Cancers, 2020, 12 (7), pp.1725. ⟨10.3390/cancers12071725⟩
Article dans une revue inserm-03084638 v1

The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets

Philippe Medina , Khadijetou Diallo , Emilie Huc‐claustre , Mehdi Attia , Régis Soulès et al.
British Journal of Pharmacology, 2020, Online ahead of print. ⟨10.1111/bph.15205⟩
Article dans une revue inserm-03084636 v1
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Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis

Salvatore Genovese , Francesco Epifano , Philippe de Médina , Nicolas Caron , Arnaud Rives et al.
Bioorganic Chemistry, 2019, 87, pp.181-190. ⟨10.1016/j.bioorg.2019.03.026⟩
Article dans une revue inserm-02380542 v1
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HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris

Vito Taddeo , Francesco Epifano , Francesca Preziuso , Serena Fiorito , Nicolas Caron et al.
Molecules, 2019, 24 (3), pp.501. ⟨10.3390/molecules24030501⟩
Article dans une revue inserm-02380544 v1
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Oxysterols: An expanding family of structurally diversified bioactive steroids

Marc Poirot , Sandrine Silvente-Poirot
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105443. ⟨10.1016/j.jsbmb.2019.105443⟩
Article dans une revue inserm-02380490 v1
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Oxysterols and sterols: from lipidomics to food sciences

M Rodriguez-Estrada , V Cardenia , Marc Poirot , L Iuliano , G. Lizard
Journal of Steroid Biochemistry and Molecular Biology, 2019, 196, pp.105515. ⟨10.1016/j.jsbmb.2019.105515⟩
Article dans une revue inserm-02380514 v1
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A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues

Régis Soules , Fabien Audouard-Combe , Emilie Huc-Claustre , Philippe de Médina , Arnaud Rives et al.
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩
Article dans une revue inserm-02380526 v1
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Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis

Allan Fouache , Nada Zabaiou , Cyrille de Joussineau , Laurent Morel , Sandrine Silvente-Poirot et al.
Journal of Steroid Biochemistry and Molecular Biology, 2019, 190, pp.173-182. ⟨10.1016/j.jsbmb.2019.03.028⟩
Article dans une revue inserm-02380571 v1
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The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells

Mathilde Bauriaud-Mallet , Lavinia Vija-Racaru , Séverine Brillouet , Arnaud Mallinger , Philippe de Médina et al.
Journal of Steroid Biochemistry and Molecular Biology, 2019, 192, pp.105390. ⟨10.1016/j.jsbmb.2019.105390⟩
Article dans une revue inserm-02380538 v1
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Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3β,5α-diol (OCDO), a tumor promoter and cholesterol metabolite

Marc Poirot , Régis Soules , Arnaud Mallinger , Florence Dalenc , Sandrine Silvente-Poirot
Biochimie, 2018, 153, pp.139-149. ⟨10.1016/j.biochi.2018.04.008⟩
Article dans une revue inserm-02380564 v1
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The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers

Sandrine Silvente-Poirot , Marc Poirot
Biochemical Pharmacology, 2018, 153, pp.75-81. ⟨10.1016/j.bcp.2018.01.046⟩
Article dans une revue inserm-02380575 v1
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Extracellular vesicles: lipids as key components of their biogenesis and functions

Michel Record , Sandrine Silvente-Poirot , Marc Poirot , Michael J. O. Wakelam
Journal of Lipid Research, 2018, 59 (8), pp.1316-1324. ⟨10.1194/jlr.E086173⟩
Article dans une revue inserm-02380557 v1
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The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer

Sandrine Silvente-Poirot , Florence Dalenc , Marc Poirot
Cancer Research, 2018, 78 (17), pp.4803-4808. ⟨10.1158/0008-5472.CAN-18-1487⟩
Article dans une revue inserm-02380586 v1
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Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment

Sandrine Silvente-Poirot , Gregory Segala , Mathias Poirot , Marc Poirot
Autophagy, 2018, 14 (3), pp.555-557. ⟨10.1080/15548627.2018.1425059⟩
Article dans une revue inserm-02380583 v1
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Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation

Farid Khallouki , Robert Owen , Sandrine Silvente-Poirot , Marc Poirot
Biomedicines, 2018, 6 (1), pp.21. ⟨10.3390/biomedicines6010021⟩
Article dans une revue inserm-02380570 v1
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Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study

Florence Dalenc , Luiggi Iuliano , Thomas Filleron , Chiara Zerbinati , Maud Voisin et al.
Journal of Steroid Biochemistry and Molecular Biology, 2017, 169, pp.210-218. ⟨10.1016/j.jsbmb.2016.06.010⟩
Article dans une revue inserm-02380620 v1
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Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry

Emmanuel Noguer , Régis Soules , Claude Netter , Citra Nagarathinam , Julie Leignadier et al.
Chemistry and Physics of Lipids, 2017, 207, pp.81-86. ⟨10.1016/j.chemphyslip.2017.06.010⟩
Article dans une revue inserm-02380602 v1
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Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS

Régis Soules , Emmanuel Noguer , Luigi Iuliano , Chiara Zerbinati , Julie Leignadier et al.
Chemistry and Physics of Lipids, 2017, 207, pp.92-98. ⟨10.1016/j.chemphyslip.2017.05.006⟩
Article dans une revue inserm-02380612 v1
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Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM-mediated autophagy, cell differentiation and death

Julie Leignadier , Florence Dalenc , Marc Poirot , Sandrine Silvente-Poirot
Biochemical Pharmacology, 2017, 144, pp.18-28. ⟨10.1016/j.bcp.2017.06.120⟩
Article dans une revue inserm-02380608 v1
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Dendrogenin A drives LXR to trigger lethal autophagy in cancers

Gregory Segala , Marion David , Philippe de Médina , Mathias Poirot , Nizar Serhan et al.
Nature Communications, 2017, 8 (1), pp.1903. ⟨10.1038/s41467-017-01948-9⟩
Article dans une revue inserm-02380591 v1
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Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

Maud Voisin , Philippe de Médina , Arnaud Mallinger , Florence Dalenc , Emilie Huc-Claustre et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (44), pp.E9346-E9355. ⟨10.1073/pnas.1707965114⟩
Article dans une revue hal-02316171 v1
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Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds

Farid Khallouki , Philippe de Médina , Stéphanie Caze-Subra , Kerstin Bystricky , Patrick Balaguer et al.
Frontiers in Oncology, 2016, 5, ⟨10.3389/fonc.2015.00287⟩
Article dans une revue hal-02271824 v1
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When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite1

Marc Poirot , Sandrine Silvente-Poirot
Biochemical Society Transactions, 2016, 44 (2), pp.631-637. ⟨10.1042/BST20150232⟩
Article dans une revue inserm-02380631 v1

Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties

Florence Dalenc , Marc Poirot , Sandrine Silvente-Poirot
Current Medicinal Chemistry, 2015, 22 (30), pp.3533-3549. ⟨10.2174/0929867322666150716114912⟩
Article dans une revue inserm-02380776 v1
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Cholesterol metabolites exported from human brain

Luigi Iuliano , Peter Crick , Chiara Zerbinati , Luigi Tritapepe , Jonas Abdel-Khalik et al.
Steroids, 2015, 99, pp.189-193. ⟨10.1016/j.steroids.2015.01.026⟩
Article dans une revue inserm-04774038 v1

Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death

Marie Tosolini , Frédéric Pont , Delphine Bétous , Emmanuel Ravet , Laetitia Ligat et al.
Molecular and Cellular Biology, 2015, 35 (2), pp.479-495. ⟨10.1128/MCB.01204-14⟩
Article dans une revue hal-01911347 v1
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Cancer. Cholesterol and cancer, in the balance.

Sandrine Silvente-Poirot , Marc Poirot
Science, 2014, 343 (6178), pp.1445-1446. ⟨10.1126/science.1252787⟩
Article dans une revue inserm-00968924 v1
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One step synthesis of 6-oxo-cholestan-3β,5α-diol.

Maud Voisin , Sandrine Silvente-Poirot , Marc Poirot
Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.782-785. ⟨10.1016/j.bbrc.2014.01.138⟩
Article dans une revue inserm-00968933 v1
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Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies.

Michel Record , Kevin Carayon , Marc Poirot , Sandrine Silvente-Poirot
BBA - Biochimica et Biophysica Acta, 2014, 1841 (1), pp.108-120. ⟨10.1016/j.bbalip.2013.10.004⟩
Article dans une revue inserm-00968935 v1
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The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

Shaden A. M. Khalifa , Philippe de Médina , Anna Erlandsson , Hesham R. El-Seedi , Sandrine Silvente-Poirot et al.
Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.681-686. ⟨10.1016/j.bbrc.2013.12.134⟩
Article dans une revue inserm-00968932 v1
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Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A.

Philippe de Médina , Michael R. Paillasse , Gregory Segala , Talal Al Saati , Jeannine Boyes et al.
Biochimie, 2013, 95 (3), pp.482-488. ⟨10.1016/j.biochi.2012.06.001⟩
Article dans une revue istex inserm-00822283 v1
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Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties.

Philippe de Médina , Michael R. Paillasse , Gregory Segala , Maud Voisin , Loubna Mhamdi et al.
Nature Communications, 2013, 4, pp.1840. ⟨10.1038/ncomms2835⟩
Article dans une revue inserm-00823974 v1
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5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells.

Gregory Segala , Philippe de Médina , Luigi Iuliano , Chiara Zerbinati , Michael R. Paillasse et al.
Biochemical Pharmacology, 2013, 86 (1), pp.175-89. ⟨10.1016/j.bcp.2013.02.031⟩
Article dans une revue inserm-00822322 v1
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Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism

Brigitte Sola , Marc Poirot , Philippe de Médina , Sophie Bustany , Véronique Marsaud et al.
Oncotarget, 2013, 4 (6), pp.911-922. ⟨10.18632/oncotarget.1066⟩
Article dans une revue inserm-00968940 v1
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Oxysterols and related sterols: Implications in pharmacology and pathophysiology.

Marc Poirot , Sandrine Silvente-Poirot
Biochemical Pharmacology, 2013, 86 (1), pp.1-2. ⟨10.1016/j.bcp.2013.05.001⟩
Article dans une revue istex inserm-00832422 v1
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MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy.

Salome Paillas , Annick Causse , Laetitia Marzi , Philippe de Médina , Marc Poirot et al.
Autophagy, 2012, 8 (7), pp.1098-112. ⟨10.4161/auto.20268⟩
Article dans une revue inserm-00705786 v1
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Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.

Michael R. Paillasse , Nathalie Saffon , Heinz Gornitzka , Sandrine Silvente-Poirot , Marc Poirot et al.
Journal of Lipid Research, 2012, 53 (4), pp.718-725. ⟨10.1194/jlr.M023689⟩
Article dans une revue inserm-00743457 v1
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Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer.

Marc Poirot , Sandrine Silvente-Poirot
Biochimie, 2012, 95 (3), pp.622-631. ⟨10.1016/j.biochi.2012.05.006⟩
Article dans une revue istex inserm-00743461 v1
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Cholesterol metabolism and cancer: the good, the bad and the ugly.

Sandrine Silvente-Poirot , Marc Poirot
Current Opinion in Pharmacology, 2012, 12 (6), pp.673-6. ⟨10.1016/j.coph.2012.10.004⟩
Article dans une revue istex inserm-00822284 v1
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Cholesterol metabolism and resistance to tamoxifen.

Marc Poirot , Sandrine Silvente-Poirot , Ralph R. Weichselbaum
Current Opinion in Pharmacology, 2012, 12 (6), pp.683-689. ⟨10.1016/j.coph.2012.09.007⟩
Article dans une revue istex inserm-00743466 v1
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Cholesterol epoxide hydrolase and cancer.

Sandrine Silvente-Poirot , Marc Poirot
Current Opinion in Pharmacology, 2012, 12 (6), pp.696-703. ⟨10.1016/j.coph.2012.07.007⟩
Article dans une revue istex inserm-00743463 v1
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Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.

Erwan Guyot , Xavier Coumoul , Jean-François Chassé , Farid Khallouki , Jean François Savouret et al.
Biochemical Pharmacology, 2012, 83 (5), pp.627-632. ⟨10.1016/j.bcp.2011.12.013⟩
Article dans une revue inserm-00743456 v1
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Exosomes as intercellular signalosomes and pharmacological effectors.

Michel Record , Caroline Subra , Sandrine Silvente-Poirot , Marc Poirot
Biochemical Pharmacology, 2011, 81 (10), pp.1171-1182. ⟨10.1016/j.bcp.2011.02.011⟩
Article dans une revue istex inserm-00743451 v1
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Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands.

Philippe de Médina , Michael R. Paillasse , Gregory Ségala , Farid Khallouki , Severine Brillouet et al.
Chemistry and Physics of Lipids, 2011, 164 (6), pp.432-437. ⟨10.1016/j.chemphyslip.2011.05.005⟩
Article dans une revue istex inserm-00743454 v1

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

Caroline Subra , David Grand , Karine Laulagnier , Alexandre Stella , Gerard Lambeau et al.
Quarterly Reviews of Biophysics, 2010, 34 (3), epub ahead of print. ⟨10.1194/jlr.M003657⟩
Article dans une revue hal-00497229 v1
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Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting.

Sandra Dorbes , Béatrice Mestre-Voegtlé , Yvon Coulais , Claude Picard , Sandrine Silvente-Poirot et al.
European Journal of Medicinal Chemistry, 2010, 45 (2), pp.423-429. ⟨10.1016/j.ejmech.2009.09.043⟩
Article dans une revue istex inserm-00519153 v1
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Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands.

Philippe de Médina , Michael R. Paillasse , Grégory Segala , Marc E. Poirot , Sandrine Silvente-Poirot
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (30), pp.13520-13525. ⟨10.1073/pnas.1002922107⟩
Article dans une revue inserm-00519159 v1
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Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors.

Philippe de Médina , Salvatore Genovese , Michael R. Paillasse , Mahta Mazaheri , Stéphanie Caze-Subra et al.
Molecular Pharmacology, 2010, 78 (5), pp.827-36. ⟨10.1124/mol.110.065250⟩
Article dans une revue inserm-00519166 v1
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Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: from molecular modeling to in vivo evaluation.

Séverine Brillouet , Sandra Dorbes , Frédéric Courbon , Claude Picard , Jean Pierre Delord et al.
Bioorganic and Medicinal Chemistry, 2010, 18 (14), pp.5400-5412. ⟨10.1016/j.bmc.2010.05.031⟩
Article dans une revue istex inserm-00519158 v1
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Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.

Michael R. Paillasse , Philippe de Médina , Guillaume Amouroux , Loubna Mhamdi , Marc E. Poirot et al.
Journal of Lipid Research, 2009, 50 (11), pp.2203-2211. ⟨10.1194/jlr.M800668-JLR200⟩
Article dans une revue inserm-00519146 v1
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Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation.

Philippe de Médina , Sandrine Silvente-Poirot , Marc E. Poirot
Autophagy, 2009, 5 (7), pp.1066-1067. ⟨10.4161/auto.5.7.9820⟩
Article dans une revue inserm-00519150 v1
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Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases.

Philippe de Médina , Michael R. Paillasse , Bruno Payré , Sandrine Silvente-Poirot , Marc E. Poirot
Journal of Medicinal Chemistry, 2009, 52 (23), pp.7765-7777. ⟨10.1021/jm901063e⟩
Article dans une revue inserm-00519151 v1
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Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism.

Philippe de Médina , Bruno Payré , Nadia Boubekeur , Justine Bertrand-Michel , François Tercé et al.
Cell Death and Differentiation, 2009, 16 (10), pp.1372-1384. ⟨10.1038/cdd.2009.62⟩
Article dans une revue inserm-00519149 v1
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Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism.

Bruno Payré , Philippe de Médina , Nadia Boubekeur , Loubna Mhamdi , Justine Bertrand-Michel et al.
Molecular Cancer Therapeutics, 2008, 7 (12), pp.3707-3718. ⟨10.1158/1535-7163.MCT-08-0507⟩
Article dans une revue inserm-00519145 v1
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Insights into the cholecystokinin 2 receptor binding site and processes of activation.

Michaël Paillasse , Céline Deraeve , Philippe de Médina , Loubna Mhamdi , Gilles Favre et al.
Molecular Pharmacology, 2006, 70 (6), pp.1935-1945. ⟨10.1124/mol.106.029967⟩
Article dans une revue inserm-00519168 v1
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The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors

Philippe de Médina , Nadia Boubekeur , Patrick Balaguer , Gilles Favre , Sandrine Silvente-Poirot et al.
Journal of Pharmacology and Experimental Therapeutics, 2006, 319 (1), pp.139-149. ⟨10.1124/jpet.106.104349⟩
Article dans une revue inserm-00090770 v1
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Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators.

Philippe de Médina , Robert Casper , Jean-François Savouret , Marc E. Poirot
Journal of Medicinal Chemistry, 2005, 48 (1), pp.287-291. ⟨10.1021/jm0498194⟩
Article dans une revue istex inserm-00090771 v1
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Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways.

Florence Dalenc , Claire Giamarchi , Mélissa Petit , Marc E. Poirot , Gilles Favre et al.
Breast Cancer Research, 2005, 7, pp.R1159-67. ⟨10.1186/bcr1357⟩
Article dans une revue inserm-00089309 v1
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Multiple targeting by the antitumor drug tamoxifen: a structure-activity study.

Philippe de Médina , Gilles Favre , Marc E. Poirot
Current Medicinal Chemistry Anticancer Agents, 2004, 4 (6), pp.491-508. ⟨10.2174/1568011043352696⟩
Article dans une revue inserm-00090772 v1
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Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells.

Philippe de Médina , Bruno Payré , José Bernad , Isabelle Bosser , Bernard Pipy et al.
Journal of Pharmacology and Experimental Therapeutics, 2004, 308 (3), pp.1165-1173. ⟨10.1124/jpet.103.060426⟩
Article dans une revue inserm-00090774 v1
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Molecular characterization of the microsomal tamoxifen binding site.

Blandine Kedjouar , Philippe de Médina , Mustapha Oulad-Abdelghani , Bruno Payré , Sandrine Silvente-Poirot et al.
Journal of Biological Chemistry, 2004, 279 (32), pp.34048-34061. ⟨10.1074/jbc.M405230200⟩
Article dans une revue inserm-00090773 v1
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Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.

Sophie F. Doisneau-Sixou , Philippe Cestac , Sarah Chouini , Jason S. Carroll , Andrew D. Hamilton et al.
Endocrinology, 2003, 144 (3), pp.989-998. ⟨10.1210/en.2002-220726⟩
Article dans une revue inserm-00090777 v1
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Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.

Céline Galés , Marc E. Poirot , Julien Taillefer , Bernard Maigret , Jean Martinez et al.
Molecular Pharmacology, 2003, 63, pp.973-982. ⟨10.1124/mol.63.5.973⟩
Article dans une revue inserm-00090776 v1
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Insulin and estrogen receptor ligand influence the FGF-2 activities in MCF-7 breast cancer cells.

Martine Garnier , Claire Giamarchi , Isabelle Delrieu , Marie-Christine Rio , Patrick Chinestra et al.
Biochemical Pharmacology, 2003, 65 (4), pp.629-636. ⟨10.1016/s0006-2952(02)01563-0⟩
Article dans une revue inserm-00090793 v1
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High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.

Céline Galés , Didier Sanchez , Marc E. Poirot , Stéphane Pyronnet , Louis Buscail et al.
Oncogene, 2003, 22, pp.6081-6089. ⟨10.1038/sj.onc.1206823⟩
Article dans une revue inserm-00090775 v1
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Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone.

Fabienne Mésange , Mohamed Sebbar , Joël Capdevielle , Jean-Claude Guillemot , Pascual Ferrara et al.
Bioconjugate Chemistry, 2002, 13 (4), pp.766-772. ⟨10.1021/bc015588t⟩
Article dans une revue inserm-00090779 v1

Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aorta.

Benoît Darblade , Dominique Caillaud , Marc E. Poirot , Marie-José Fouque , Jean-Claude Thiers et al.
Cardiovascular Research, 2001, 50, pp.566-76
Article dans une revue inserm-00090792 v1
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Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS).

Marc E. Poirot , Philippe de Médina , Frédéric Delarue , Jean-Jacques Perie , Alain Klaebe et al.
Bioorganic and Medicinal Chemistry, 2000, 8 (8), pp.2007-2016. ⟨10.1016/s0968-0896(00)00119-x⟩
Article dans une revue inserm-00090778 v1
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Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor.

Blandine Kedjouar , Sylvie Daunes , Berthols J. Vilner , Wayne D. Bowen , Alain Klaebe et al.
Biochemical Pharmacology, 1999, 58 (12), pp.1927-1939. ⟨10.1016/s0006-2952(99)00285-3⟩
Article dans une revue inserm-00090780 v1
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Modifications of benzylphenoxy ethanamine antiestrogen molecules: influence affinity for antiestrogen binding site (AEBS) and cell cytotoxicity.

Frédéric Delarue , Blandine Kedjouar , Fabienne Mésange , Francis Bayard , Jean-Charles Faye et al.
Biochemical Pharmacology, 1999, 57 (6), pp.657-661. ⟨10.1016/s0006-2952(98)00347-5⟩
Article dans une revue inserm-00090781 v1
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Microsomal epoxide hydrolase of rat liver is a subunit of the anti-oestrogen-binding site.

Fabienne Mésange , Mohamed Sebbar , Blandine Kedjouar , Joël Capdevielle , Jean-Claude Guillemot et al.
Biochemical Journal, 1998, 334 ( Pt 1), pp.107-112. ⟨10.1042/bj3340107⟩
Article dans une revue inserm-00090782 v1
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Different populations of progesterone receptor-steroid complexes in binding to specific DNA sequences: effects of salts on kinetics and specificity.

Sergei Y. Plisov , Marc E. Poirot , Kevin J. Modarress , Alice H. Cavanaugh , Dean P. Edwards et al.
Journal of Steroid Biochemistry and Molecular Biology, 1998, 67 (3), pp.251-266. ⟨10.1016/s0960-0760(98)00118-6⟩
Article dans une revue inserm-00090783 v1

Characterization of the membranous antiestrogen binding protein: II. Purification to homogeneity.

Marc E. Poirot , Catherine Chailleux , Fabienne Mesange , Francis Bayard , Jean-Charles Faye
J Recept Res, 1994, 14, pp.37-46
Article dans une revue inserm-00090794 v1

Characterization of the membranous antiestrogen binding protein: I. Partial purification of the protein in its active state.

Catherine Chailleux , Marc E. Poirot , Fabienne Mésange , Francis Bayard , Jean-Charles Faye
J Recept Res, 1994, 14, pp.23-35
Article dans une revue inserm-00090795 v1
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Characterization of a benzyl-phenoxy-ethanamine binding protein in Trypanosoma equiperdum and the possible relation between binding affinity and trypanocidal activity.

Didier Betbeder , Jean-Jacques Perie , Théo Baltz , Marc E. Poirot , Jean-Charles Faye
Molecular and Biochemical Parasitology, 1993, 58 (2), pp.311-316. ⟨10.1016/0166-6851(93)90053-z⟩
Article dans une revue inserm-00090796 v1

Cytosolic type II estrogen binding site in rat uterus: specific photolabeling with estrone.

Marc E. Poirot , Catherine Chailleux , Francis Bayard , Jean-Charles Faye
J Recept Res, 1992, 12, pp.217-31
Article dans une revue inserm-00090797 v1
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The anti-proliferative properties of 4-benzylphenoxy ethanamine derivatives are mediated by the anti-estrogen binding site (ABS), whereas the anti-estrogenic effects of trifluopromazine are not.

Marc E. Poirot , Martine Garnier , Francis Bayard , Isabelle Riviere , Moussa Traore et al.
Biochemical Pharmacology, 1990, 40 (3), pp.425-429. ⟨10.1016/0006-2952(90)90539-w⟩
Article dans une revue inserm-00090799 v1
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A potent and selective photoaffinity probe for the anti-estrogen binding site of rat liver.

Marc E. Poirot , Catherine Chailleux , Annick Fargin , Francis Bayard , Jean-Charles Faye
Journal of Biological Chemistry, 1990, 265 (28), pp.17039-17043
Article dans une revue inserm-00090798 v1
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Further evidence for a biological role of anti-estrogen-binding sites in mediating the growth inhibitory action of diphenylmethane derivatives.

Annick Fargin , Francis Bayard , Jean-Charles Faye , Moussa Traore , Marc E. Poirot et al.
Chemico-Biological Interactions, 1988, 66 (12), pp.101-109. ⟨10.1016/0009-2797(88)90044-0⟩
Article dans une revue inserm-00090800 v1

Etude des protéines modulatrices du tamoxifène et de ses dérivés

Marc Poirot
Sciences du Vivant [q-bio]. Université de Toulouse 3 - Paul Sabatier, 2003
HDR tel-04774246 v1