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Marc Poirot

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Is cholesterol a risk factor for breast cancer incidence and outcome?

Céline Ben Hassen , Caroline Goupille , Claire Vigor , Thierry Durand , Françoise Guéraud
Journal of Steroid Biochemistry and Molecular Biology, inPress, pp.106346. ⟨10.1016/j.jsbmb.2023.106346⟩
Journal articles hal-04165228v1
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An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management

Farid Khallouki , Lhoussain Hajji , Somayya Saber , Toufik Bouddine , Mouad Edderkaoui
Journal of Personalized Medicine, 2023, 13 (5), pp.754. ⟨10.3390/jpm13050754⟩
Journal articles inserm-04165318v1
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European Network for oxysterol research (ENOR): 10th ENOR symposium – Web meeting

Gérard Lizard , Marc Poirot , Luigi Iuliano
Steroids, 2023, 195, pp.109242. ⟨10.1016/j.steroids.2023.109242⟩
Journal articles inserm-04165320v1
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Oxysterols are potential physiological regulators of ageing

Philippe de Medina , Sandrine Silvente-Poirot , Marc Poirot
Ageing Research Reviews - ARR, 2022, 77, pp.101615. ⟨10.1016/j.arr.2022.101615⟩
Journal articles inserm-03629546v1
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Sterol metabolism and cancer

Marc Poirot
Biochemical Pharmacology, 2022, 196, pp.114843. ⟨10.1016/j.bcp.2021.114843⟩
Journal articles inserm-03649225v1

Targeting NR1H/liver X receptor with dendrogenin A differentiates tumor cells to activate a new secretory pathway releasing immunogenic anti-tumor vesicles enriched in LC3-II-associated exosomes

Philippe de Medina , Julio Bunay , Marc Poirot , Michel Record , Sandrine Silvente-Poirot
Autophagy, 2022, pp.1-3. ⟨10.1080/15548627.2022.2116175⟩
Journal articles inserm-03854248v1
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Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

Michel Record , Mehdi Attia , Kevin Carayon , Laly Pucheu , Julio Bunay
Journal of Extracellular Vesicles, 2022, 11 (4), pp.e12211. ⟨10.1002/jev2.12211⟩
Journal articles inserm-03649213v1
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Celebrating the 10th anniversary of the creation of the European Network for Oxysterol Research (ENOR)

Gérard Lizard , Marc Poirot , Luigi Iuliano
Journal of Steroid Biochemistry and Molecular Biology, 2022, pp.106114. ⟨10.1016/j.jsbmb.2022.106114⟩
Journal articles inserm-03649224v1
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In vitro and In vivo oxidation and cleavage products of tocols: From chemical tuners to “VitaminEome” therapeutics. A narrative review

Farid Khallouki , Somayya Saber , Toufik Bouddine , Lhoussain Hajji , Bachir Elbouhali
Food Bioscience, 2022, pp.101839. ⟨10.1016/j.fbio.2022.101839⟩
Journal articles inserm-03703644v1
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European network for oxysterol research (ENOR): 10 th anniversary

Gérard Lizard , Marc Poirot , Luigi Iuliano
Journal of Steroid Biochemistry and Molecular Biology, 2021, 214, pp.105996. ⟨10.1016/j.jsbmb.2021.105996⟩
Journal articles inserm-03394448v1
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The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets

Philippe Medina , Khadijetou Diallo , Emilie Huc‐claustre , Mehdi Attia , Régis Soulès
British Journal of Pharmacology, 2021, 178 (16), pp.3248-3260. ⟨10.1111/bph.15205⟩
Journal articles inserm-03394464v1
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Pharmacologic and genetic inhibition of cholesterol esterification enzymes reduces tumour burden: A systematic review and meta-analysis of preclinical models

Alex Websdale , Yi Kiew , Philip Chalmers , Xinyu Chen , Giorgia Cioccoloni
Biochemical Pharmacology, 2021, pp.114731. ⟨10.1016/j.bcp.2021.114731⟩
Journal articles inserm-03394456v1
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel Klionsky , Amal Kamal Abdel-Aziz , Sara Abdelfatah , Mahmoud Abdellatif , Asghar Abdoli
Autophagy, 2021, 17 (1), pp.1-382. ⟨10.1080/15548627.2020.1797280⟩
Journal articles inserm-03285572v1

The 5,6-epoxycholesterol metabolic pathway in cancer: emergence of new pharmacological targets

Philippe de Médina , Khadijetou Diallo , Emilie Huc Claustre , Mehdi Attia , Régis Soulès
British Journal of Pharmacology, 2020, Online ahead of print. ⟨10.22541/au.159069407.75369904⟩
Journal articles inserm-03086999v1
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Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia

Pierre-Luc Mouchel , Nizar Serhan , Rémy Bétous , Thomas Farge , Estelle Saland
Cancers, 2020, 12 (10), pp.2933. ⟨10.3390/cancers12102933⟩
Journal articles inserm-03084630v1

The 5,6‐epoxycholesterol metabolic pathway in breast cancer: Emergence of new pharmacological targets

Philippe Medina , Khadijetou Diallo , Emilie Huc‐claustre , Mehdi Attia , Régis Soulès
British Journal of Pharmacology, 2020, Online ahead of print. ⟨10.1111/bph.15205⟩
Journal articles inserm-03084636v1
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Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

Nizar Serhan , Pierre-Luc Mouchel , Philippe de Médina , Gregory Segala , Aurélie Mougel
Cancers, 2020, 12 (7), pp.1725. ⟨10.3390/cancers12071725⟩
Journal articles inserm-03084638v1
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Oxysterols: An expanding family of structurally diversified bioactive steroids

Marc Poirot , Sandrine Silvente-Poirot
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105443. ⟨10.1016/j.jsbmb.2019.105443⟩
Journal articles inserm-02380490v1
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Natural and semisynthetic oxyprenylated aromatic compounds as stimulators or inhibitors of melanogenesis

Salvatore Genovese , Francesco Epifano , Philippe de Médina , Nicolas Caron , Arnaud Rives
Bioorganic Chemistry, 2019, 87, pp.181-190. ⟨10.1016/j.bioorg.2019.03.026⟩
Journal articles inserm-02380542v1
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HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris

Vito Taddeo , Francesco Epifano , Francesca Preziuso , Serena Fiorito , Nicolas Caron
Molecules, 2019, 24 (3), pp.501. ⟨10.3390/molecules24030501⟩
Journal articles inserm-02380544v1
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The cholesterol-derived metabolite dendrogenin A functionally reprograms breast adenocarcinoma and undifferentiated thyroid cancer cells

Mathilde Bauriaud-Mallet , Lavinia Vija-Racaru , Séverine Brillouet , Arnaud Mallinger , Philippe de Médina
Journal of Steroid Biochemistry and Molecular Biology, 2019, 192, pp.105390. ⟨10.1016/j.jsbmb.2019.105390⟩
Journal articles inserm-02380538v1
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A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues

Régis Soules , Fabien Audouard-Combe , Emilie Huc-Claustre , Philippe de Médina , Arnaud Rives
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105447. ⟨10.1016/j.jsbmb.2019.105447⟩
Journal articles inserm-02380526v1
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Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis

Allan Fouache , Nada Zabaiou , Cyrille de Joussineau , Laurent Morel , Sandrine Silvente-Poirot
Journal of Steroid Biochemistry and Molecular Biology, 2019, 190, pp.173-182. ⟨10.1016/j.jsbmb.2019.03.028⟩
Journal articles inserm-02380571v1
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Oxysterols and sterols: from lipidomics to food sciences

M Rodriguez-Estrada , V Cardenia , Marc Poirot , L Iuliano , G. Lizard
Journal of Steroid Biochemistry and Molecular Biology, 2019, 196, pp.105515. ⟨10.1016/j.jsbmb.2019.105515⟩
Journal articles inserm-02380514v1
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The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer

Sandrine Silvente-Poirot , Florence Dalenc , Marc Poirot
Cancer Research, 2018, 78 (17), pp.4803-4808. ⟨10.1158/0008-5472.CAN-18-1487⟩
Journal articles inserm-02380586v1
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The tumor-suppressor cholesterol metabolite, dendrogenin A, is a new class of LXR modulator activating lethal autophagy in cancers

Sandrine Silvente-Poirot , Marc Poirot
Biochemical Pharmacology, 2018, 153, pp.75-81. ⟨10.1016/j.bcp.2018.01.046⟩
Journal articles inserm-02380575v1
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Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3β,5α-diol (OCDO), a tumor promoter and cholesterol metabolite

Marc Poirot , Régis Soules , Arnaud Mallinger , Florence Dalenc , Sandrine Silvente-Poirot
Biochimie, 2018, 153, pp.139-149. ⟨10.1016/j.biochi.2018.04.008⟩
Journal articles inserm-02380564v1
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Extracellular vesicles: lipids as key components of their biogenesis and functions

Michel Record , Sandrine Silvente-Poirot , Marc Poirot , Michael J. O. Wakelam
Journal of Lipid Research, 2018, 59 (8), pp.1316-1324. ⟨10.1194/jlr.E086173⟩
Journal articles inserm-02380557v1
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Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation

Farid Khallouki , Robert Owen , Sandrine Silvente-Poirot , Marc Poirot
Biomedicines, 2018, 6 (1), pp.21. ⟨10.3390/biomedicines6010021⟩
Journal articles inserm-02380570v1
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Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment

Sandrine Silvente-Poirot , Gregory Segala , Mathias Poirot , Marc Poirot
Autophagy, 2018, 14 (3), pp.555-557. ⟨10.1080/15548627.2018.1425059⟩
Journal articles inserm-02380583v1
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Improving the efficacy of hormone therapy in breast cancer: The role of cholesterol metabolism in SERM-mediated autophagy, cell differentiation and death

Julie Leignadier , Florence Dalenc , Marc Poirot , Sandrine Silvente-Poirot
Biochemical Pharmacology, 2017, 144, pp.18-28. ⟨10.1016/j.bcp.2017.06.120⟩
Journal articles inserm-02380608v1
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Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study

Florence Dalenc , Luiggi Iuliano , Thomas Filleron , Chiara Zerbinati , Maud Voisin
Journal of Steroid Biochemistry and Molecular Biology, 2017, 169, pp.210-218. ⟨10.1016/j.jsbmb.2016.06.010⟩
Journal articles inserm-02380620v1

Dendrogenin A drives LXR to trigger lethal autophagy in cancers

Gregory Segala , Marion David , Philippe de Médina , Mathias Poirot , Nizar Serhan
Nature Communications, 2017, 8 (1), pp.1903. ⟨10.1038/s41467-017-01948-9⟩
Journal articles inserm-02380591v1
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Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS

Régis Soules , Emmanuel Noguer , Luigi Iuliano , Chiara Zerbinati , Julie Leignadier
Chemistry and Physics of Lipids, 2017, 207, pp.92-98. ⟨10.1016/j.chemphyslip.2017.05.006⟩
Journal articles inserm-02380612v1
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Quantitative analysis of the tumor suppressor dendrogenin A using liquid chromatography tandem mass spectrometry

Emmanuel Noguer , Régis Soules , Claude Netter , Citra Nagarathinam , Julie Leignadier
Chemistry and Physics of Lipids, 2017, 207, pp.81-86. ⟨10.1016/j.chemphyslip.2017.06.010⟩
Journal articles inserm-02380602v1

Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

Maud Voisin , Philippe de Médina , Arnaud Mallinger , Florence Dalenc , Emilie Huc-Claustre
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (44), pp.E9346-E9355. ⟨10.1073/pnas.1707965114⟩
Journal articles hal-02316171v1
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Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds

Farid Khallouki , Philippe de Médina , Stéphanie Caze-Subra , Kerstin Bystricky , Patrick Balaguer
Frontiers in Oncology, 2016, 5, ⟨10.3389/fonc.2015.00287⟩
Journal articles hal-02271824v1
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When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite1

Marc Poirot , Sandrine Silvente-Poirot
Biochemical Society Transactions, 2016, 44 (2), pp.631-637. ⟨10.1042/BST20150232⟩
Journal articles inserm-02380631v1

Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties

Florence Dalenc , Marc Poirot , Sandrine Silvente-Poirot
Current Medicinal Chemistry, 2015, 22 (30), pp.3533-3549. ⟨10.2174/0929867322666150716114912⟩
Journal articles inserm-02380776v1

Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death

Marie Tosolini , Frédéric Pont , Delphine Bétous , Emmanuel Ravet , Laetitia Ligat
Molecular and Cellular Biology, 2015, 35 (2), pp.479-495. ⟨10.1128/MCB.01204-14⟩
Journal articles hal-01911347v1

The novel steroidal alkaloids dendrogenin A and B promote proliferation of adult neural stem cells.

Shaden A. M. Khalifa , Philippe de Médina , Anna Erlandsson , Hesham R. El-Seedi , Sandrine Silvente-Poirot
Biochemical and Biophysical Research Communications, 2014, 446 (3), pp.681-6. ⟨10.1016/j.bbrc.2013.12.134⟩
Journal articles inserm-00968932v1

Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies.

Michel Record , Kevin Carayon , Marc Poirot , Sandrine Silvente-Poirot
BBA - Biochimica et Biophysica Acta, 2014, 1841 (1), pp.108-20. ⟨10.1016/j.bbalip.2013.10.004⟩
Journal articles inserm-00968935v1

One step synthesis of 6-oxo-cholestan-3β,5α-diol.

Maud Voisin , Sandrine Silvente-Poirot , Marc Poirot
Biochemical and Biophysical Research Communications, 2014, epub ahead of print. ⟨10.1016/j.bbrc.2014.01.138⟩
Journal articles inserm-00968933v1

Cancer. Cholesterol and cancer, in the balance.

Sandrine Silvente-Poirot , Marc Poirot
Science, 2014, 343 (6178), pp.1445-6. ⟨10.1126/science.1252787⟩
Journal articles inserm-00968924v1

Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties.

Philippe de Médina , Michael R. Paillasse , Gregory Segala , Maud Voisin , Loubna Mhamdi
Nature Communications, 2013, 4, pp.1840. ⟨10.1038/ncomms2835⟩
Journal articles inserm-00823974v1

Oxysterols and related sterols: Implications in pharmacology and pathophysiology.

Marc Poirot , Sandrine Silvente-Poirot
Biochemical Pharmacology, 2013, epub ahead of print. ⟨10.1016/j.bcp.2013.05.001⟩
Journal articles inserm-00832422v1
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5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells.

Gregory Segala , Philippe de Médina , Luigi Iuliano , Chiara Zerbinati , Michael R. Paillasse
Biochemical Pharmacology, 2013, 86 (1), pp.175-89. ⟨10.1016/j.bcp.2013.02.031⟩
Journal articles inserm-00822322v1
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Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism

Brigitte Sola , Marc Poirot , Philippe de Médina , Sophie Bustany , Véronique Marsaud
Oncotarget, 2013, 4 (6), pp.911-922. ⟨10.18632/oncotarget.1066⟩
Journal articles inserm-00968940v1

Technical note: Hapten synthesis, antibody production and development of an enzyme-linked immunosorbent assay for detection of the natural steroidal alkaloid Dendrogenin A.

Philippe de Médina , Michael R. Paillasse , Gregory Segala , Talal Al Saati , Jeannine Boyes
Biochimie, 2013, 95 (3), pp.482-8. ⟨10.1016/j.biochi.2012.06.001⟩
Journal articles inserm-00822283v1

Cholesterol metabolism and cancer: the good, the bad and the ugly.

Sandrine Silvente-Poirot , Marc Poirot
Current Opinion in Pharmacology, 2012, 12 (6), pp.673-6. ⟨10.1016/j.coph.2012.10.004⟩
Journal articles inserm-00822284v1

Cholesterol epoxide hydrolase and cancer.

Sandrine Silvente-Poirot , Marc Poirot
Current Opinion in Pharmacology, 2012, 12 (6), pp.696-703. ⟨10.1016/j.coph.2012.07.007⟩
Journal articles inserm-00743463v1

Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.

Michael R. Paillasse , Nathalie Saffon , Heinz Gornitzka , Sandrine Silvente-Poirot , Marc Poirot
Journal of Lipid Research, 2012, 53 (4), pp.718-25. ⟨10.1194/jlr.M023689⟩
Journal articles inserm-00743457v1
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MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy.

Salome Paillas , Annick Causse , Laetitia Marzi , Philippe de Médina , Marc Poirot
Autophagy, 2012, 8 (7), pp.1098-112. ⟨10.4161/auto.20268⟩
Journal articles inserm-00705786v1

Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer.

Marc Poirot , Sandrine Silvente-Poirot
Biochimie, 2012, 95 (3), pp.622-31. ⟨10.1016/j.biochi.2012.05.006⟩
Journal articles inserm-00743461v1

Cholesterol metabolism and resistance to tamoxifen.

Marc Poirot , Sandrine Silvente-Poirot , Ralph R. Weichselbaum
Current Opinion in Pharmacology, 2012, 12 (6), pp.683-9. ⟨10.1016/j.coph.2012.09.007⟩
Journal articles inserm-00743466v1
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Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.

Erwan Guyot , Xavier Coumoul , Jean-François Chassé , Farid Khallouki , Jean François Savouret
Biochemical Pharmacology, 2012, 83 (5), pp.627-632. ⟨10.1016/j.bcp.2011.12.013⟩
Journal articles inserm-00743456v1

Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands.

Philippe de Médina , Michael R. Paillasse , Gregory Ségala , Farid Khallouki , Severine Brillouet
Chemistry and Physics of Lipids, 2011, 164 (6), pp.432-7. ⟨10.1016/j.chemphyslip.2011.05.005⟩
Journal articles inserm-00743454v1

Exosomes as intercellular signalosomes and pharmacological effectors.

Michel Record , Caroline Subra , Sandrine Silvente-Poirot , Marc Poirot
Biochemical Pharmacology, 2011, 81 (10), pp.1171-82. ⟨10.1016/j.bcp.2011.02.011⟩
Journal articles inserm-00743451v1

Auraptene is an inhibitor of cholesterol esterification and a modulator of estrogen receptors.

Philippe de Médina , Salvatore Genovese , Michael R. Paillasse , Mahta Mazaheri , Stéphanie Caze-Subra
Molecular Pharmacology, 2010, epub ahead of print. ⟨10.1124/mol.110.065250⟩
Journal articles inserm-00519166v1

Synthesis, characterization and in vitro evaluation of new oxorhenium- and oxotechnetium-CCK4 derivatives as molecular imaging agents for CCK2-receptor targeting.

Sandra Dorbes , Béatrice Mestre-Voegtlé , Yvon Coulais , Claude Picard , Sandrine Silvente-Poirot
European Journal of Medicinal Chemistry, 2010, 45 (2), pp.423-9. ⟨10.1016/j.ejmech.2009.09.043⟩
Journal articles inserm-00519153v1

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

Caroline Subra , David Grand , Karine Laulagnier , Alexandre Stella , Gerard Lambeau
Quarterly Reviews of Biophysics, 2010, 34 (3), epub ahead of print. ⟨10.1194/jlr.M003657⟩
Journal articles hal-00497229v1

Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands.

Philippe de Médina , Michael R. Paillasse , Grégory Segala , Marc E. Poirot , Sandrine Silvente-Poirot
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (30), pp.13520-5. ⟨10.1073/pnas.1002922107⟩
Journal articles inserm-00519159v1

Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: from molecular modeling to in vivo evaluation.

Séverine Brillouet , Sandra Dorbes , Frédéric Courbon , Claude Picard , Jean Pierre Delord
Bioorganic and Medicinal Chemistry, 2010, 18 (14), pp.5400-12. ⟨10.1016/j.bmc.2010.05.031⟩
Journal articles inserm-00519158v1

Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation.

Philippe de Médina , Sandrine Silvente-Poirot , Marc E. Poirot
Autophagy, 2009, 5 (7), pp.1066-7
Journal articles inserm-00519150v1

Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.

Michael R. Paillasse , Philippe de Médina , Guillaume Amouroux , Loubna Mhamdi , Marc E. Poirot
Journal of Lipid Research, 2009, 50 (11), pp.2203-11. ⟨10.1194/jlr.M800668-JLR200⟩
Journal articles inserm-00519146v1

Synthesis of new alkylaminooxysterols with potent cell differentiating activities: identification of leads for the treatment of cancer and neurodegenerative diseases.

Philippe de Médina , Michael R. Paillasse , Bruno Payré , Sandrine Silvente-Poirot , Marc E. Poirot
Journal of Medicinal Chemistry, 2009, 52 (23), pp.7765-77. ⟨10.1021/jm901063e⟩
Journal articles inserm-00519151v1

Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism.

Philippe de Médina , Bruno Payré , Nadia Boubekeur , Justine Bertrand-Michel , François Tercé
Cell Death and Differentiation, 2009, 16 (10), pp.1372-84. ⟨10.1038/cdd.2009.62⟩
Journal articles inserm-00519149v1

Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism.

Bruno Payré , Philippe de Médina , Nadia Boubekeur , Loubna Mhamdi , Justine Bertrand-Michel
Molecular Cancer Therapeutics, 2008, 7 (12), pp.3707-18. ⟨10.1158/1535-7163.MCT-08-0507⟩
Journal articles inserm-00519145v1

Insights into the cholecystokinin 2 receptor binding site and processes of activation.

Michaël Paillasse , Céline Deraeve , Philippe de Médina , Loubna Mhamdi , Gilles Favre
Molecular Pharmacology, 2006, 70 (6), pp.1935-45. ⟨10.1124/mol.106.029967⟩
Journal articles inserm-00519168v1

The prototypical inhibitor of cholesterol esterification, Sah 58-035 is an agonist of estrogen receptors.

Philippe de Médina , Nadia Boubekeur , Patrick Balaguer , Gilles Favre , Sandrine Silvente-Poirot
J Pharmacol Exp Ther, 2006, 319, pp.139. ⟨10.1124/jpet.106.104349⟩
Journal articles inserm-00090770v1

Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators.

Philippe de Médina , Robert Casper , Jean-François Savouret , Marc E. Poirot
Journal of Medicinal Chemistry, 2005, 48, pp.287-91. ⟨10.1021/jm0498194⟩
Journal articles inserm-00090771v1
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Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways.

Florence Dalenc , Claire Giamarchi , Mélissa Petit , Marc E. Poirot , Gilles Favre
Breast Cancer Research, 2005, 7, pp.R1159-67. ⟨10.1186/bcr1357⟩
Journal articles inserm-00089309v1

Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells.

Philippe de Médina , Bruno Payré , José Bernad , Isabelle Bosser , Bernard Pipy
J Pharmacol Exp Ther, 2004, 308, pp.1165-73. ⟨10.1124/jpet.103.060426⟩
Journal articles inserm-00090774v1

Molecular characterization of the microsomal tamoxifen binding site.

Blandine Kedjouar , Philippe de Médina , Mustapha Oulad-Abdelghani , Bruno Payré , Sandrine Silvente-Poirot
Journal of Biological Chemistry, 2004, 279, pp.34048-61. ⟨10.1074/jbc.M405230200⟩
Journal articles inserm-00090773v1

Multiple targeting by the antitumor drug tamoxifen: a structure-activity study.

Philippe de Médina , Gilles Favre , Marc E. Poirot
Current Medicinal Chemistry Anticancer Agents, 2004, 4, pp.491-508
Journal articles inserm-00090772v1

High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.

Céline Galés , Didier Sanchez , Marc E. Poirot , Stéphane Pyronnet , Louis Buscail
Oncogene, 2003, 22, pp.6081-9. ⟨10.1038/sj.onc.1206823⟩
Journal articles inserm-00090775v1

Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies.

Céline Galés , Marc E. Poirot , Julien Taillefer , Bernard Maigret , Jean Martinez
Molecular Pharmacology, 2003, 63, pp.973-82
Journal articles inserm-00090776v1

Contrasting effects of prenyltransferase inhibitors on estrogen-dependent cell cycle progression and estrogen receptor-mediated transcriptional activity in MCF-7 cells.

Sophie F. Doisneau-Sixou , Philippe Cestac , Sarah Chouini , Jason S. Carroll , Andrew D. Hamilton
Endocrinology, 2003, 144, pp.989-98
Journal articles inserm-00090777v1

Insulin and estrogen receptor ligand influence the FGF-2 activities in MCF-7 breast cancer cells.

Martine Garnier , Claire Giamarchi , Isabelle Delrieu , Marie-Christine Rio , Patrick Chinestra
Biochemical Pharmacology, 2003, 65, pp.629-36
Journal articles inserm-00090793v1

Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone.

Fabienne Mésange , Mohamed Sebbar , Joël Capdevielle , Jean-Claude Guillemot , Pascual Ferrara
Bioconjug Chem, 2002, 13, pp.766-72
Journal articles inserm-00090779v1

Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aorta.

Benoît Darblade , Dominique Caillaud , Marc E. Poirot , Marie-José Fouque , Jean-Claude Thiers
Cardiovascular Research, 2001, 50, pp.566-76
Journal articles inserm-00090792v1

Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS).

Marc E. Poirot , Philippe de Médina , Frédéric Delarue , Jean-Jacques Perie , Alain Klaebe
Bioorganic and Medicinal Chemistry, 2000, 8, pp.2007-16
Journal articles inserm-00090778v1

Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor.

Blandine Kedjouar , Sylvie Daunes , Berthols J. Vilner , Wayne D. Bowen , Alain Klaebe
Biochemical Pharmacology, 1999, 58, pp.1927-39
Journal articles inserm-00090780v1

Modifications of benzylphenoxy ethanamine antiestrogen molecules: influence affinity for antiestrogen binding site (AEBS) and cell cytotoxicity.

Frédéric Delarue , Blandine Kedjouar , Fabienne Mésange , Francis Bayard , Jean-Charles Faye
Biochemical Pharmacology, 1999, 57, pp.657-61
Journal articles inserm-00090781v1

Microsomal epoxide hydrolase of rat liver is a subunit of the anti-oestrogen-binding site.

Fabienne Mésange , Mohamed Sebbar , Blandine Kedjouar , Joël Capdevielle , Jean-Claude Guillemot
Biochemical Journal, 1998, 334 ( Pt 1), pp.107-12
Journal articles inserm-00090782v1

Different populations of progesterone receptor-steroid complexes in binding to specific DNA sequences: effects of salts on kinetics and specificity.

Sergei Y. Plisov , Marc E. Poirot , Kevin J. Modarress , Alice H. Cavanaugh , Dean P. Edwards
Journal of Steroid Biochemistry and Molecular Biology, 1998, 67, pp.251-66
Journal articles inserm-00090783v1

Characterization of the membranous antiestrogen binding protein: I. Partial purification of the protein in its active state.

Catherine Chailleux , Marc E. Poirot , Fabienne Mésange , Francis Bayard , Jean-Charles Faye
J Recept Res, 1994, 14, pp.23-35
Journal articles inserm-00090795v1

Characterization of the membranous antiestrogen binding protein: II. Purification to homogeneity.

Marc E. Poirot , Catherine Chailleux , Fabienne Mesange , Francis Bayard , Jean-Charles Faye
J Recept Res, 1994, 14, pp.37-46
Journal articles inserm-00090794v1

Characterization of a benzyl-phenoxy-ethanamine binding protein in Trypanosoma equiperdum and the possible relation between binding affinity and trypanocidal activity.

Didier Betbeder , Jean-Jacques Perie , Théo Baltz , Marc E. Poirot , Jean-Charles Faye
Molecular and Biochemical Parasitology, 1993, 58, pp.311-6
Journal articles inserm-00090796v1

Cytosolic type II estrogen binding site in rat uterus: specific photolabeling with estrone.

Marc E. Poirot , Catherine Chailleux , Francis Bayard , Jean-Charles Faye
J Recept Res, 1992, 12, pp.217-31
Journal articles inserm-00090797v1

A potent and selective photoaffinity probe for the anti-estrogen binding site of rat liver.

Marc E. Poirot , Catherine Chailleux , Annick Fargin , Francis Bayard , Jean-Charles Faye
Journal of Biological Chemistry, 1990, 265, pp.17039-43
Journal articles inserm-00090798v1

The anti-proliferative properties of 4-benzylphenoxy ethanamine derivatives are mediated by the anti-estrogen binding site (ABS), whereas the anti-estrogenic effects of trifluopromazine are not.

Marc E. Poirot , Martine Garnier , Francis Bayard , Isabelle Riviere , Moussa Traore
Biochemical Pharmacology, 1990, 40, pp.425-9
Journal articles inserm-00090799v1

Further evidence for a biological role of anti-estrogen-binding sites in mediating the growth inhibitory action of diphenylmethane derivatives.

Annick Fargin , Francis Bayard , Jean-Charles Faye , Moussa Traore , Marc E. Poirot
Chemico-Biological Interactions, 1988, 66, pp.101-9
Journal articles inserm-00090800v1

Generation of whole-body scintigraphic images with new GATE output capacities

Marie-Paule Garcia , Daphnée Villoing , Erin Mckay , Ludovic Ferrer , Henri Der Sarkissian
IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), IEEE, Oct 2013, Seoul, South Korea. pp.1-3, ⟨10.1109/NSSMIC.2013.6829150⟩
Conference papers hal-01133300v1