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Marie-Christine CHAGNON

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Parmi les nombreuses sources de contaminants potentiels des aliments, **les substances emballages** sont souvent incriminés. En effet, des substances chimiques présentes dans les matériaux au contact des denrées alimentaires (MCDA) peuvent migrer vers les aliments. Ces composés, retrouvés en très faibles quantités, peuvent cependant induire des modifications organoleptiques inacceptables, être toxiques par eux-mêmes ou par les produits générés. L’étude du danger que représente l'ensemble des substances capables de migrer de l'emballage vers l'aliment permet une meilleure évaluation de l'emballage fini. Les effets toxiques potentiels des extraits des emballages finis peuvent donc être testés d’un point de vue toxicologique en utilisant des tests de screening *in vitro*, précoces, sensibles et spécifiques, dénommés « **biotests** ». Certains sont déjà utilisés pour les dossiers d’autorisation pour les substances intentionnelles. Les résultats des biotests peuvent être corrélés aux données analytiques afin d’identifier le ou les substances responsables. Si les données analytiques n’expliquent pas l’effet toxique observé, il peut être dû soit à une substance non identifiée dans le mélange, soit à un effet « **cocktail** ».

Publications

Identification of non-volatile non-intentionally added substances from polyester food contact coatings and genotoxicity assessment of polyester coating's migrates

Ruzanna Hayrapetyan , Ronan Cariou , Anne Platel , Julie Santos , Ludovic Huot
Food and Chemical Toxicology, 2024, 185 (1-3), pp.114484. ⟨10.1016/j.fct.2024.114484⟩
Journal articles hal-04431727v1

Protective properties of the edible halophyte Carpobrotus edulis (L.) N.E.Br. towards neoformed food contaminants-related oxidative stress and genotoxicity

Daniela Oliveira , Ruzanna Hayrapetyan , Maria Inês Dias , Lillian Barros , Isabelle Séverin
Food Bioscience, inPress, pp.104447. ⟨10.1016/j.fbio.2024.104447⟩
Journal articles hal-04614106v1
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Cocktails of endocrine disruptors in the different diets of French consumers

Gaud Dervilly , Manon Bourdeau , Manon Pruvost-Couvreur , Isabelle Severin , Anne Platel
Environment International, 2024, 183, pp.108408. ⟨10.1016/j.envint.2023.108408⟩
Journal articles hal-04401254v1

Stratégie pour une sécurité chimique intégrée des matériaux d’emballage au contact des denrées alimentaires

Isabelle Séverin , Laurence Dahbi , Sandra Domenek , Phuong-Mai Nguyen , Anne Platel
Cahiers de Nutrition et de Diététique, 2023, 58 (2), pp.134-141. ⟨10.1016/j.cnd.2022.12.005⟩
Journal articles hal-03927663v1

The cell transformation assay to assess potential carcinogenic properties of nanoparticles

Ruzanna Hayrapetyan , Théo Lacour , Luce Annette , Francis Finot , Marie-Christine Chagnon
Mutation Research - Reviews, 2023, 791, pp.108455. ⟨10.1016/j.mrrev.2023.108455⟩
Journal articles hal-04044912v1
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Migration Studies and Endocrine Disrupting Activities: Chemical Safety of Cosmetic Plastic Packaging

Elias Bou-Maroun , Laurence Dahbi , Laurence Dujourdy , Pierre-Jacques Ferret , Marie-Christine Chagnon
Polymers, 2023, 15 (19), pp.4009. ⟨10.3390/polym15194009⟩
Journal articles hal-04253662v1

Epoxiconazole alters the histology and transcriptome of mouse liver in a transgenerational pattern

Ludovic Le Corre , Axelle Brulport , Daniel Vaiman , Marie-Christine Chagnon
Chemico-Biological Interactions, 2022, 360, pp.109952. ⟨10.1016/j.cbi.2022.109952⟩
Journal articles hal-03690009v1

In vitro and in silico approach to study the hormonal activities of the alternative plasticizer tri-(2-ethylhexyl) trimellitate TEHTM and its metabolites

Laurence Dahbi , Amaury Farce , Nicolas Kambia , Isabelle Séverin , Thierry Dine
Archives of Toxicology, 2022, 96, pp.899-918. ⟨10.1007/s00204-022-03230-4⟩
Journal articles hal-03546832v1
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Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet

Axelle Brulport , Ludovic Le Corre , Guillaume Maquart , Virginie Barbet , Aurélie Dastugue
Environmental Pollution, 2021, 270, pp.116243. ⟨10.1016/j.envpol.2020.116243⟩
Journal articles hal-03148322v1
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Transgenerational effects on intestinal inflammation status in mice perinatally exposed to bisphenol S

Axelle Brulport , Corinne Lencina , Marie-Christine Chagnon , Ludovic Le Corre , Laurence Guzylack-Piriou
Journal articles hal-02964984v1
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Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies

Nicolas Kambia , Isabelle Séverin , Amaury Farce , Laurence Dahbi , Thierry Dine
Metabolites, 2021, 11 (2), pp.94. ⟨10.3390/metabo11020094⟩
Journal articles hal-03141182v1

Development of a new methodology to determine size differences of nanoparticles with nanoparticle tracking analysis

Yann Pellequer , Gilbert Zanetta , Jean-Michel Rebibou , Isabelle Séverin , Marie-Christine Chagnon
Applied Nanoscience, 2021, 11, pp.2129-2141. ⟨10.1007/s13204-021-01932-2⟩
Journal articles hal-03281325v1
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Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver

Axelle Brulport , Daniel Vaiman , Marie-Christine Chagnon , Ludovic Le Corre
Chemosphere, 2020, 241, pp.125092. ⟨10.1016/j.chemosphere.2019.125092⟩
Journal articles hal-02325508v1
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Lemon Juice, Sesame Paste, and Autoclaving Influence Iron Bioavailability of Hummus: Assessment by an In Vitro Digestion/Caco-2 Cell Model

Nour Doumani , Isabelle Séverin , Laurence Dahbi , Elias Bou-Maroun , Maya Tueni
Foods, 2020, 9 (4), pp.474-494. ⟨10.3390/foods9040474⟩
Journal articles hal-02551705v1
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Hepatic transcriptome and DNA methylation patterns following perinatal and chronic BPS exposure in male mice

Axelle Brulport , Daniel Vaiman , Elias Bou-Maroun , Marie-Christine Chagnon , Ludovic Le Corre
BMC Genomics, 2020, 21 (1), pp.881. ⟨10.1186/s12864-020-07294-3⟩
Journal articles hal-03114886v1
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In vitro and in silico hormonal activity studies of di-(2-ethylhexyl)terephthalate, a di-(2-ethylhexyl)phthalate substitute used in medical devices, and its metabolites

Nicolas Kambia , Isabelle Séverin , Amaury Farce , Emmanuel Moreau , Laurence Dahbi
Journal of Applied Toxicology, 2019, 39, pp.1043-1056. ⟨10.1002/jat.3792⟩
Journal articles hal-02068658v1
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Lebanese Population Exposure to Trace Elements via White Bread Consumption

Nada Lebbos , Claude Daou , Rosette R. Ouaini , Hanna H. Chebib , Michel Afram
Foods, 2019, 8 (11), pp.574. ⟨10.3390/foods8110574⟩
Journal articles hal-02380322v1
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FITNESS, première plateforme européenne sur l’emballage et le conditionnement des aliments

Antoine Kieffer , Catherine Loriot , Patrick P. Sauvegrain , Jean Mario Julien , Mai Nguyen
IAA La revue des industries agroalimentaires, 2019, pp.24-26
Journal articles hal-02511722v1

Genotoxic effects of food contact recycled paperboard extracts on two human hepatic cell lines.

Emilie Souton , Isabelle Séverin , Ludovic Le Hegarat , Kevin Hogeveen , Abdulhadi Aljawish
Food additives & contaminants. Part A. Chemistry, analysis, control, exposure & risk assessment, 2018, 35 (1), pp.159-170. ⟨10.1080/19440049.2017.1397774⟩
Journal articles hal-01625970v1

Are epigenetic modifications linked to BPS obesogen effect after perinatal exposure? Differential DNA methylation study in mouse livers

Axelle Brulport , Ludovic Le Corre , Daniel Vaiman , Marie-Christine Chagnon
Toxicology Letters, 2018, 295 (Supplement 1), pp.S132. ⟨10.1016/j.toxlet.2018.06.698⟩
Journal articles hal-01959924v1
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In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line

Teuta Eljezi , Pierre Pinta , Damien Richard Richard , Jérémy Pinguet , Jean-Michel Chezal
Chemosphere, 2017, 173, pp.452 - 459. ⟨10.1016/j.chemosphere.2017.01.026⟩
Journal articles inserm-01856278v1

Use of bioassays to assess hazard of food contact material extracts: State of the art

Isabelle Séverin , Emilie Souton , Laurence Dahbi , Marie-Christine Chagnon
Food and Chemical Toxicology, 2017, 105, pp.429-447. ⟨10.1016/j.fct.2017.04.046⟩
Journal articles hal-01560265v1

Chronic exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces an obesogenic effect in C57BL/6J mice fed a high fat diet

Axelle Brulport , Ludovic Le Corre , Marie-Christine Chagnon
Toxicology, 2017, 390, pp.43-52. ⟨10.1016/j.tox.2017.07.017⟩
Journal articles hal-01577444v1

Chemical analysis and potential endocrine activities of aluminium coatings intended to be in contact with cosmetic water

Elias Bou-Maroun , Laurence Dahbi , Marie-Pierre Pierre , Philippine Pierre , Sandrine Rakotomalala
Journal of Pharmaceutical and Biomedical Analysis, 2017, 145, pp.641 - 650. ⟨10.1016/j.jpba.2017.07.061⟩
Journal articles hal-01616383v1
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Obesogen effects after perinatal exposure of 4,4′-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice

L. Ivry del Moral , Ludovic Le Corre , Hélène Poirier , Isabelle Niot , T. Truntzer
Toxicology, 2016, 357-358, pp.11 - 20. ⟨10.1016/j.tox.2016.05.023⟩
Journal articles hal-01431231v1
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The consequences of physical post-treatments (microwave and electron-beam) on food/packaging interactions: A physicochemical and toxicological approach

Anne-Marie Riquet-Motchidlover , Colette Breysse , Laurence Dahbi , Catherine Loriot , Isabelle Séverin
Food Chemistry, 2016, 199, pp.59-69. ⟨10.1016/j.foodchem.2015.09.034⟩
Journal articles hal-01243319v1
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In vitro toxicity assessment of extracts derived from sol–gel coatings on polycarbonate intended to be used in food contact applications

Isabelle Séverin , Krystelle Lionti , Laurence Dahbi , Catherine Loriot , Bérangère Toury
Food and Chemical Toxicology, 2016, 93, pp.51 - 57. ⟨10.1016/j.fct.2016.04.025⟩
Journal articles hal-01434899v1

Migration of plasticizers from PVC medical devices: Development of an infusion model.

Lise Bernard , R. Cueff , Marie-Christine Chagnon , F. Abdoulouhab , Bertrand Décaudin
International Journal of Pharmaceutics, 2015, 494 (1), pp.136-145. ⟨10.1016/j.ijpharm.2015.08.033⟩
Journal articles hal-03611985v1

Use of reliable bioassays to detect potential hazard of food contact materials extracts to ensure quality, safety and innovation of paperboards

Emilie Souton , Isabelle Séverin , Marie-Christine Chagnon
Toxicology Letters, 2015, Toxicology Letters, 238 (2, supplément), pp.S1-420
Journal articles hal-03611999v1

BPA, an Energy Balance Disruptor

Ludovic Le Corre , Philippe Besnard , Marie-Christine Chagnon
Critical Reviews in Food Science and Nutrition, 2014, 55 (6), pp.769-777. ⟨10.1080/10408398.2012.678421⟩
Journal articles hal-01960190v1

Effect of sunlight exposure on the release of intentionally and/or non-intentionally added substances from polyethylene terephthalate (PET) bottles into water: Chemical analysis and in vitro toxicity

Cristina Bach , Xavier Dauchy , Isabelle Séverin , Jean-Francois Munoz , Serge Etienne
Food Chemistry, 2014, 162, pp.63-71. ⟨10.1016/j.foodchem.2014.04.020⟩
Journal articles hal-01296979v1

Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: A focus on their potential involvement in nonalcoholic fatty liver disease

Ludovic Peyre , Patrick Rouimi , Georges de Sousa , Cécile Héliès-Toussaint , Benjamin Carre
Food and Chemical Toxicology, 2014, 70, pp.9 - 18. ⟨10.1016/j.fct.2014.04.011⟩
Journal articles hal-02638648v1

Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study

Cécile Héliès-Toussaint , Ludovic Peyre , Claudia Costanzo , Marie-Christine Chagnon , Roger Rahmani
Toxicology and Applied Pharmacology, 2014, 280 (2), pp.224-235. ⟨10.1016/j.taap.2014.07.025⟩
Journal articles hal-02641516v1

P019: Effet obésogène des bisphénols A et S chez la souris C57Bl/6

L. Ivry-del Moral , Ludovic Le Corre , Kévin Gaire , Cécile Héliès-Toussaint , Hélène Poirier
Nutrition Clinique et Métabolisme, 2014, 28, ⟨10.1016/S0985-0562(14)70662-4⟩
Journal articles hal-01915989v1

In vitro genotoxicity assessment of MTES, GPTES and TEOS, three precursors intended for use in food contact coatings

Krystelle Lionti , Isabelle Séverin , Laurence Dahbi , Bérangère Toury , Marie-Christine Chagnon
Food and Chemical Toxicology, 2014, 65, pp.76-81. ⟨10.1016/j.fct.2013.11.037⟩
Journal articles hal-01962377v1

Estrogen receptor α and aryl hydrocarbon receptor cross-talk in a transfected hepatoma cell line (HepG2) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Manuela Göttel , Ludovic Le Corre , Coralie Dumont , Dieter Schrenk , Marie-Christine Chagnon
Toxicology Reports, 2014, 1, pp.1029-1036. ⟨10.1016/j.toxrep.2014.09.016⟩
Journal articles hal-01960137v1

Effect of temperature on the release of intentionally and non-intentionally added substances from polyethylene terephthalate (PET) bottles into water: Chemical analysis and potential toxicity

Cristina Bach , Xavier Dauchy , Isabelle Séverin , Jean-François Munoz , Serge Etienne
Food Chemistry, 2013, 139 (1-4), pp.672 - 680. ⟨10.1016/j.foodchem.2013.01.046⟩
Journal articles anses-01903693v1

Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells

Micheline Dsamou , Martine Morzel , Ludovic Le Corre , Isabelle Séverin , Marie-Christine Chagnon
Archives of Oral Biology, 2013, 58 (10), pp.1511-1516. ⟨10.1016/j.archoralbio.2013.06.005⟩
Journal articles hal-01960219v1

Effet obésogène du bisphénol A sur des souris C57Bl/6 sous régime hyperlipidique

Ludovic Le Corre , Lydie Ivry-del Moral , Philippe Besnard , Marie-Christine Chagnon
Cahiers de Nutrition et de Diététique, 2013, 48 (3), pp.129-136. ⟨10.1016/j.cnd.2013.02.003⟩
Journal articles hal-01961507v1
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Chemical migration in drinking water stored in polyethylene terephthalate (PET) bottles: a source of controversy reviewed

Cristina Bach , Xavier Dauchy , Marie-Christine Chagnon , Serge Etienne
Water Research, 2012, 46 (3), pp. 571-583. ⟨10.1016/j.watres.2011.11.062⟩
Journal articles hal-00683918v1

Bisphenol A disrupts the intestinal lipid metabolism

Ludovic Le Corre , Lydie Ivry Del Moral , Philippe Besnard , Marie-Christine Chagnon
Toxicology Letters, 2012, 211, pp.S210. ⟨10.1016/j.toxlet.2012.03.753⟩
Journal articles hal-01961543v1
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Salivary protein profiles and sensitivity to the bitter taste of caffeine.

Micheline Dsamou , Olivier Palicki , Chantal Septier , Claire Chabanet , Géraldine Lucchi
Chemical Senses, 2012, 37 (1), pp.87-95. ⟨10.1093/chemse/bjr070⟩
Journal articles hal-00723339v1

Developmental toxic potential of di-n-propyl phthalate administered orally to rats.

Anne-Marie Saillenfait , Alain-Claude Roudot , Frédéric Gallissot , Jean-Philippe Sabaté , Marie-Christine Chagnon
Journal of Applied Toxicology, 2011, 31 (1), pp.36-44. ⟨10.1002/jat.1565⟩
Journal articles hal-00723070v1

Risk assessment and management–Food contact materials

Isabelle Séverin , Anne-Marie Riquet , Marie-Christine Chagnon
Cahiers de Nutrition et de Diététique, 2011, 46 (2), pp.59-66. ⟨10.1016/j.cnd.2010.11.003⟩
Journal articles hal-01962438v1

Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes

Coralie Dumont , Elisabeth Perdu , Georges de Sousa , Laurent Debrauwer , Roger Rahmani
Drug and Chemical Toxicology, 2011, 34 (4), pp.445-453. ⟨10.3109/01480545.2011.585651⟩
Journal articles hal-02651168v1

Bisphenol a exposure in C57Bl/6 mice fed with a high fat diet

Ludovic Le Corre , Philippe Besnard , Marie-Christine Chagnon
Toxicology Letters, 2011, 205 (Supplement), pp.S143-S143. ⟨10.1016/j.toxlet.2011.05.508⟩
Journal articles hal-00723043v1

In-mouth mechanisms leading to flavor release and perception.

Christian Salles , Marie-Christine Chagnon , Gilles Feron , Elisabeth Guichard , Hélène Labouré
Critical Reviews in Food Science and Nutrition, 2011, 51 (1), pp.67-90. ⟨10.1080/10408390903044693⟩
Journal articles hal-00823384v1

Cross talk between nuclear receptor ERalpha ET AhR in human hepatoma cell line (HepG2) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Manuela Goettel , Ludovic Le Corre , Isabelle Séverin , Dieter Schrenk , Marie-Christine Chagnon
Toxicology Letters, 2011, Abstracts of the 47th Congress of the European Societies of Toxicology (EUROTOX), 205, pp.S239-S239. ⟨10.1016/j.toxlet.2011.05.817⟩
Journal articles hal-00722931v1

Genotoxic activities of the food contaminant 5-hydroxymethylfurfural using different in vitro bioassays

Isabelle Séverin , Coralie Dumont , Adeline Jondeau-Cabaton , Vanessa Graillot , Marie-Christine Chagnon
Toxicology Letters, 2010, 192 (2), pp.189-194. ⟨10.1016/j.toxlet.2009.10.022⟩
Journal articles hal-00850790v1

Transferts de matière au travers des emballages au contact de produits alimentaires

Anne Endrizzi , Thomas Karbowiak , Frédéric Debeaufort , David Chassagne , Marie-Christine Chagnon
Industries Alimentaires et Agricoles, 2009, 2009-009/010, pp.11-16
Journal articles hal-03565946v1

Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines

Céline Gasnier , Coralie Dumont , Nora Benachour , Emilie Clair , Marie-Christine Chagnon
Toxicology, 2009, 262 (3), pp.184-191. ⟨10.1016/j.tox.2009.06.006⟩
Journal articles hal-03426636v1
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Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro

François Chauvigné , Arnaud Menuet , Laurianne Lesné , Marie-Christine Chagnon , Cécile Chevrier
Environmental Health Perspectives, 2009, 117 (4), pp.515-21. ⟨10.1289/ehp.11870⟩
Journal articles hal-00669512v1

Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line

Nicolas J. Cabaton , Coralie Dumont , Isabelle Séverin , Elisabeth Perdu , Daniel Zalko
Toxicology, 2009, 255 (1-2), pp.15-24. ⟨10.1016/j.tox.2008.09.024⟩
Journal articles hal-01962644v1

Biotransformation of bisphenol F by human and rat liver subcellular fractions

Nicolas J. Cabaton , Daniel Zalko , Estelle Rathahao-Paris , Cécile Canlet , Georges Delous
Toxicology in Vitro, 2008, 22 (7), pp.1697-1704. ⟨10.1016/j.tiv.2008.07.004⟩
Journal articles hal-01173776v1

Effects of endocrine disruptors on genes associated with 17 beta-estradiol metabolism and excretion

Nathalie Hanet , Allan Lancon , Dominique Delmas , Brigitte Jannin , Marie-Christine Chagnon
Steroids, 2008, 73 (12), pp.1242-1251. ⟨10.1016/j.steroids.2008.06.005⟩
Journal articles hal-02662141v1
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Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes.

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel
Drug Metabolism and Disposition, 2007, 35 (5), pp.699-703. ⟨10.1124/dmd.106.013664⟩
Journal articles hal-00259260v1

Effect of in utero exposure to di-(2-ethylhexyl)phthalate: Distribution in the rat fetus and testosterone production by rat fetal testis in culture

Thomas Stroheker , Jean-François Regnier , Julie Lassurguère , Marie-Christine Chagnon
Food and Chemical Toxicology, 2006, 44 (12), pp.2064-2069. ⟨10.1016/j.fct.2006.07.007⟩
Journal articles hal-02664478v1

Disposition and metabolic profiling of bisphenol F in pregnant and nonpregnant rats

Nicolas J. Cabaton , Marie-Christine Chagnon , Jean-Claude Lhuguenot , Jean Pierre J. P. Cravedi , Daniel Zalko
Journal of Agricultural and Food Chemistry, 2006, 54 (26), pp.10307-10314. ⟨10.1021/jf062250q⟩
Journal articles hal-02668619v1
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Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants

Adeline Jondeau , Laurence Dahbi , Marie-Helene Bani-Estivals , Marie-Christine Chagnon
Toxicology, 2006, 226 (2-3), pp.218-228. ⟨10.1016/j.tox.2006.07.007⟩
Journal articles hal-00294427v1

Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate

Thomas Stroheker , Nicolas Cabatona , Gorian Nourdin , Jean-François Regnier , Jean-Claude Lhuguenota
Toxicology, 2005, 208 (1), pp.115-121. ⟨10.1016/j.tox.2004.11.013⟩
Journal articles hal-02680300v1

Pharmacokinetic and metabolism of apigenin in female and male rats after a single oral administration

Angeline Gradolatto , Jean-Philippe Basly , Raymond Bergès , Caroline Teyssier , Marie-Christine Chagnon
Drug Metabolism and Disposition, 2005, 33 (1), pp.49-54. ⟨10.1124/dmd.104.000893⟩
Journal articles hal-02677921v1

2,4-Diaminotoluene (2,4-DAT)-induced DNA damage, DNA repair and micronucleus formation in the human hepatoma cell line HepG2

Isabelle Séverin , Adeline Jondeau , Laurence Dahbi , Marie-Christine Chagnon
Toxicology, 2005, 213 (1-2), pp.138-146. ⟨10.1016/j.tox.2005.05.021⟩
Journal articles hal-01981435v1

The autoradiographic test for unscheduled DNA synthesis: a sensitive assay for the detection of DNA repair in the HepG2 cell line

Isabelle Valentin-Severin , Véronique Thybaud , Anne-Marie Le Bon , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2004, 559 (1-2), pp.211-217. ⟨10.1016/j.mrgentox.2003.12.007⟩
Journal articles hal-01981453v1

Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis

D. Guyonnet , Raymond Bergès , M.H. Siess , M.F. Pinnert , Marie-Christine Chagnon
Food and Chemical Toxicology, 2004, 42, pp.1479-1485
Journal articles hal-02679472v1

The autoradiographic test for unscheduled DNA synthesis : a sensitive assay for the detection of DNA repair in the HepG2 cell line

Isabelle Valentin-Severin , V. Thybaud , A.M. Lebon , J.C. Lhuguenot , Marie-Christine Chagnon
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2004, 559, pp.211-217
Journal articles hal-02672058v1

Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis

D. Guyonnet , Raymond Bergès , M.H. Siess , M.F. Pinnert , Marie-Christine Chagnon
Food and Chemical Toxicology, 2004, 42 (9), pp.1479-1485
Journal articles hal-02677820v1

Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines

T. Stroheker , K. Picard , J.C. Lhuguenot , Marie-Chantal Canivenc-Lavier , Marie-Christine Chagnon
Food and Chemical Toxicology, 2004, 42, pp.887-897
Journal articles hal-02679474v1
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Influence of dietary soy isoflavones on the accessory sex organs of the Wistar rat

Thomas Stroheker , Nicolas J. Cabaton , Raymond Berges , Valérie Lamothe , Jean-Claude Lhuguenot
Food and Chemical Toxicology, 2003, 41 (8), pp.1175-83. ⟨10.1016/S0278-6915(03)00108-X⟩
Journal articles hal-02681581v1

Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats : a comparative study

Thomas Stroheker , Marie-Christine Chagnon , Marie-France Pinnert , Raymond Bergès , Marie-Chantal Canivenc-Lavier
Reproductive Toxicology, 2003, 17 (4), pp.421-432
Journal articles hal-02679922v1

Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.

Isabelle Valentin-Severin , Ludovic Le Hegarat , Jean-Claude Lhuguenot , Anne-Marie Le Bon , Marie-Christine Chagnon
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2003, 536 (1-2), pp.79-90. ⟨10.1016/S1383-5718(03)00031-7⟩
Journal articles hal-01981654v1

Toxic interaction between hydroxyurea and 1-beta-D-arabino-furanosylcytosine on the DNA of a human hepatoma cell line (HEPG2).

Isabelle Séverin , Martine Padieu , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Toxicology Letters, 2003, 145 (3), pp.303-11. ⟨10.1016/j.toxlet.2003.08.003⟩
Journal articles hal-01981468v1

Use of HepG2 cell line for direct or indirect mutagens screening : comparative investigation between comet and micronucleus assays

Isabelle Valentin-Severin , L. Le Hagarat , J.C. Lhuguenot , A.M. Lebon , Marie-Christine Chagnon
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2003, 536, pp.79-90
Journal articles hal-02680011v1

Uridine uptake inhibition assay: an automated micromethod for the screening of cytotoxicity.

Isabelle Valentin-Severin , Laurence Laignelet , Jean Claude Lhuguenot , Marie-Christine Chagnon
Toxicology, 2002, 171 (2-3), pp.207-13. ⟨10.1016/S0300-483X(01)00587-X⟩
Journal articles hal-01981698v1

Estrogenic activity and metabolism of N-butyl benzyl phtalate in vitro : identification of the active molecule(s)

K. Picard , J.C. Lhuguenot , Marie-Chantal Canivenc-Lavier , Marie-Christine Chagnon
Toxicology and Applied Pharmacology, 2001, 172, pp.108-118
Journal articles hal-02675409v1
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Uridine uptake inhibition as a cytotoxicity test for a human hepatoma cell line (HepG2 cells): comparison with the neutral red assay

Isabelle Valentin , Murielle Philippe , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Toxicology, 2001, 158, pp.127-139
Journal articles hal-01981819v1
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Metabolism of N-Butyl Benzyl Phthalate in the Female Wistar Rat. Identification of New Metabolites

C Nativelle , K Picard , Isabelle Valentin , Jean-Claude C Lhuguenot , Marie-Christine Chagnon
Food and Chemical Toxicology, 1999, 37, pp.905-917
Journal articles hal-01981781v1

Metabolism of N-butyl benzyl phtalate in the female wistar rat. Identification of new metabolites

C. Nativelle , K. Picard , Isabelle Valentin , J.C. Lhuguenot , Marie-Christine Chagnon
Food and Chemical Toxicology, 1999, 37, pp.905-917
Journal articles hal-02694753v1

P XIX.9 Migration and mutagenic potentiality of food contact materials: A new strategy for testing their safety

Isabelle Leguy , Anne-Marie Le Bon , Christine Belloir , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 1997, 379 (1), pp.S198-S199. ⟨10.1016/S0027-5107(97)83306-4⟩
Journal articles hal-03978096v1

Fenofibrate: Metabolism and Species Differences for Peroxisome Proliferation in Cultured Hepatocytes

Marie-Christine Chagnon , H Dupont , A Edgar
Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, 26 (1), pp.63-74. ⟨10.1006/faat.1995.1075⟩
Journal articles hal-03978100v1

Ascorbic acid uptake by isolated rat hepatocytes: Stimulatory effect of diquat, a redox cycling compound

Marie-Christine Chagnon , Gregory Adam Moore , Yoshio Nakagawa , Peter Moldéus
Biochemical Pharmacology, 1993, 46 (8), pp.1333-1338. ⟨10.1016/0006-2952(93)90096-f⟩
Journal articles hal-03978103v1

Identification of the proximate peroxisome proliferator(S) derived from DI (2-ethylhexyl) adipate and species differences in response

Marie-Christine Chagnon , Jean-Claude Lhuguenot , A.M. Brady , R. Moore , C.R. Elcombe
Biochemical Pharmacology, 1992, 43 (10), pp.2129-2134. ⟨10.1016/0006-2952(92)90171-e⟩
Journal articles hal-03978116v1

Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid

Y. Keith , Marie-Christine Chagnon , P. Canning , J. Foster , Jean-Claude Lhuguenot
Archives of Toxicology, 1992, 66 (5), pp.321-326. ⟨10.1007/BF01973626⟩
Journal articles hal-03978113v1

Di-(2-ethylhexyl) Adipate and Peroxisome Proliferation: Identification of Proximate Peroxisomal Proliferator In Vivo and In Vitro

Y. Keith , Marie-Christine Chagnon , C. Elcombe , Jean-Claude Lhuguenot
Archives of Toxicology, 1988, Archives of Toxicology, 12, pp.274-277. ⟨10.1007/978-3-642-73113-6_45⟩
Journal articles hal-03978126v1

In vivo and in vitro metabolism of di-(2 ethylhexyl) adipate, a peroxisome proliferator in the rat

Marie-Christine Chagnon , Y. Keith , C. Elcombe , Jean-Claude Lhuguenot
Archives of Toxicology, 1988, Archives of Toxicology, 12, pp.265-268. ⟨10.1007/978-3-642-73113-6_43⟩
Journal articles hal-03978151v1

P03-04: Safety evaluation of can's polyester coatings using and approaches

Ruzanna Hayrapetyan , Isabelle Séverin , Ronan Cariou , Marie-Christine Chagnon
57th Congress of the European-Societies-of-Toxicology (EUROTOX), Sep 2023, Ljubljana, Slovenia. pp.S84, ⟨10.1016/S0378-4274(23)00468-X⟩
Conference papers hal-04279594v1

Risk assessment of endocrine-disrupting cocktail effect from multiexposure to plasticizers of medical devices in the neonatal population

Lise Bernard , Marie-Christine Chagnon , Laurence Dahbi , Valérie Sautou
15th International Congress of Toxicology, Sep 2022, Maastricht, Netherlands
Conference papers hal-04066086v1

P22-05 Identification and hazard assessment of oligoesters, nonintentionally added substances present in food contact coating extracts

Ruzanna Hayrapetyan , Isabelle Séverin , V. Monneraye , R. Cariou , Marie-Christine Chagnon
16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Sep 2022, Maastricht, Netherlands. pp.S271-S271, ⟨10.1016/j.toxlet.2022.07.719⟩
Conference papers hal-03948279v1

Risk assessment of endocrine-disrupting cocktail effect from multiexposure to plasticizers of medical devices in the neonatal population

L. Bernard , Laurence Dahbi , Marie-Christine Chagnon , Valérie Sautou
16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Sep 2022, Maastricht, Netherlands. pp.S76-S76, ⟨10.1016/j.toxlet.2022.07.225⟩
Conference papers hal-04007388v1

Chemical analysis of metallic trace elements of toxicological concern in Lebanese pita and risk characterization for the consumers

N. Lebbos , Elias Bou-Maroun , C. Daou , R. Ouaini , H. Chebib
54. Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, Sep 2018, Bruxelles, Belgium. ⟨10.1016/j.toxlet.2018.06.791⟩
Conference papers hal-02733845v1

Bisphenol S is obesogen in male mice after perinatal exposure

Marie-Christine Chagnon , Lydie Ivry-del Moral , Ludovic Le Corre , Roger Rahmani
51. Congress of the European-Societies-of-Toxicology (EUROTOX), European Societies of Toxicology (EUROTOX)., Sep 2015, Porto, Portugal. 1 p., ⟨10.1016/j.toxlet.2015.08.1058⟩
Conference papers hal-02741257v1

CIME: An integrative and multidisciplinary PNR-PE project on Chronic Impact of ED Mixture Exposure at environmental low doses on Reproduction, Development and Behavior

Marie-Chantal Canivenc-Lavier , Martine Applanat , Thuy-Anh Auxiètre , Sylvie Babajko , Ariane Berdal
Colloque PNR-PE, Dec 2012, Paris, France. 1 p
Conference papers hal-01595174v1

Effects of genistein, vinclozolin and BPA on the proliferation and differentiation of a human salivary cell line – CIME project

Laurence Dhabi , Isabelle Séverin , Marie-Chantal Canivenc-Lavier , Marie-Christine Chagnon
Colloque PNR-PE , Dec 2012, Paris, France. 1 p
Conference papers hal-01594399v1

FP7: The Human Submandibular Gland (HSG) cell line: a tool to study the regulation of salivary markers of bitterness perception

Micheline Dsamou , Martine Morzel , Marie-Christine Chagnon
Food Oral Processing: Physics, Physiology, and Psychology of Eating. Session 7: In-mouth biological mechanisms at the origin of sensory perception, Jul 2012, Beaune, France. 1 p
Conference papers hal-00723343v1

Food contact materials: Strategy for quality and food safety of packaging systems

Isabelle Séverin , Laurence Dahbi , Catherine Bergès , Coralie Dumont , Marie-Christine Chagnon
47. Congress of the European-Societies-of-Toxicology, Aug 2011, Paris, France. 2 p., ⟨10.1016/j.toxlet.2011.05.732⟩
Conference papers hal-02749456v1

Sensitivity to bitterness: may in-mouth proteolysis be involved?

Micheline Dsamou , Olivier Palicki , Chantal Septier , Claire Chabanet , Géraldine Lucchi
9. Pangborn sensory science symposium, Sep 2011, Toronto, Canada. 1 p
Conference papers hal-01594410v1
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Mechanism of TCDD-induced oxidative stress, role of estrogen receptor, and modulation by estradiol in liver cells

Manuela Göttel , Marie-Christine Chagnon , Dieter Schrenk
49. Annual Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mar 2008, Mainz, Germany. pp.88
Conference papers hal-03426732v1

Etude du métabolisme in vitro du bisphénol F

Nicolas J. Cabaton , Elisabeth Perdu , Estelle Rathahao-Paris , Cécile Canlet , Jean-Pierre Cravedi
Colloque ARET 2007, Jun 2007, Maisons-Alfort, France
Conference papers hal-03757609v1

Identification of genotoxic and endocrine disruption activities of 4,4’-dihydroxydiphenyl-methane (BPF) and its metabolites using human cell lines

N J Cabaton , Coralie Dumont , Isabelle Séverin , Daniel Zalko , Marie-Christine Chagnon
Congrès Annuel de la Société Française de toxicologie, Oct 2007, Montpellier, France
Conference papers hal-03593237v1

Use of bcl2 stably transfected HepG2 cell line to improve the specificity of the comet assay

Isabelle Séverin , Marie-Odile Eichler , Laurence Dahbi , Marie-Christine Chagnon
Molecular Research in Environmental Medicine, 2. international conference, Sep 2006, Paris, France
Conference papers hal-03592899v1
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Effet perturbateur endocrinien de l’apigénine chez le rat femelle immature

Thomas Stroheker , Angeline Gradolatto , Marie-France Pinnert , Caroline Teyssier , Marie-Christine Chagnon
21e forum de cancérologie, Jun 2001, Paris, France. 1 p
Conference papers hal-02833937v1

Strategy using a combination of physico/chemical analysis and in vitro bioassays for chemical safety of food contact articles

Isabelle Séverin , Laurence Dahbi , Sandra Domenek , Phuong-Mai Nguyen , Anne Platel
RiskTOX 2023, Nov 2023, Valencia (Espagne), Spain
Conference poster hal-04375350v1
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Could CTA be a reliable alternative method to identify non-genotoxic substances in Food Contact Material extract ?

Théo Lacour , Ruzanna Hayrapetyan , Isabelle Séverin , Isabelle Mouche , Francis Finot
ICT 2022 The XVIth International Congress of Toxicology, Sep 2022, Maastricht, Netherlands. , 368, pp.S141, 2022, ⟨10.1016/j.toxlet.2022.07.402⟩
Conference poster hal-03819008v1
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Lebanese pita extracts with presence of trace elements: hazard assessment

Isabelle Séverin , Elias Bou-Maroun , Rita Akiki , Ghiwa Zoghbi , Nada Lebbos
47th Meeting of the European Environmental Mutagenesis and Genomics Society (EEMGS), May 2019, Rennes, France. ⟨10.13140/RG.2.2.30583.88489⟩
Conference poster hal-02296298v1
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Extraction d'éléments traces métalliques à partir de pains libanais et évaluation du danger de ces mélanges

Isabelle Séverin , N. Lebbos , Elias Bou-Maroun , C. Daou , R. Ouaini
SFT 2018, 2018, Dijon, France
Conference poster hal-01986057v1

Metallic contamination of wheat-cultivated soils in the Bekaa flatland of Lebanon

N. Lebbos , Elias Bou-Maroun , R. Daou , H. Ouaini , H. Chebib
Proceedings of the 14th International Conference on the Biogeochemistry of Trace Elements (ICOBTE), Jul 2017, Zürich, Switzerland
Conference poster hal-03556335v1
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Genotoxicity assessment of a polycarbonate sol-gel coating and its precursors intended to be used for food contact

Isabelle Séverin , K. Lionti , Laurence Dahbi , C. Loriot , Bérangère Toury
2016 ILSI Annual Meeting, Jan 2016, St. Petersburg, Fl, United States.
Conference poster hal-01989582v1
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Reliable bioassays to detect potential hazard of paperboard food contact material extracts

Emilie Souton , Laurence Dahbi , Thomas Nury , Abdulhadi Aljawish , Isabelle Séverin
European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016
Conference poster hal-01989751v1
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In vitro hazard assessment of nanoparticles developed for biomedical applications

Annette Luce , Y Saibi , Isabelle Séverin , Julien Boudon , Nadine Millot
European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016
Conference poster hal-01986190v1
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Use of reliable bioassays to detect potential hazard of food contact materials extracts to ensure quality, safety and innovation of paperboards

Emilie Souton , Isabelle Séverin , Marie-Christine Chagnon
51st Congress of the European Societies of Toxicology (EUROTOX), Sep 2015, Porto, Portugal. 51st Congress of the European Societies of Toxicology (EUROTOX), 238 (2, supplément), pp.S348, 2015, Toxicology Letters
Conference poster hal-01985967v1

Effects of Bisphenol A and its substitutes on the proliferation and differentiation in Caco-2 intestine cell model: MELBA project.

L. Ivry-del Moral , Laurent Le Corre , Roger Rahmani , Cécile Héliès-Toussaint , Marie-Christine Chagnon
PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012
Conference poster hal-02809669v1

Le BPS, une bonne alternative au BPA ? Effets métaboliques du BPA et du BPS dans les hépatocytes et les adipocytes - Projet MELBA -

Claudia Costanzo , Patrick Rouimi , Georges de Sousa , Marie-Christine Chagnon , Roger Rahmani
PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012
Conference poster hal-02806503v1

An integrative and multidisciplinary PNR-PE project for studying Chronic Impact of ED Mixture Exposures at environmental low doses on reproduction, development and behavior.

Marie-Chantal Canivenc-Lavier , M Applanat , Ta Auxiètre , S Babajko , A Berdal
PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012
Conference poster hal-02807429v1
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Salivary proteome and sensitivity to bitterness

Micheline Dsamou , Olivier Palicki , Chantal Septier , Isabelle Séverin , Marie-Christine Chagnon
5. Congrès international goût-nutrition-santé, Mar 2010, Dijon, France. 1 p., 2010
Conference poster hal-01137080v1

Endocrine disruptors found in food modulate estradiol cellular metabolism

Nathalie Hanet , Allan Lançon , Jean-Marie Heydel , Dominique Delmas , Brigitte Jannin
2. congrès international Santé et Nutrition VITAGORA, Mar 2007, Dijon, France
Conference poster hal-03757959v1

Effects of estradiol on TCDD-induced oxidative stress in liver cells

Manuela Goettel , Marie-Christine Chagnon , Dieter Schrenk
symposium Food chemistry and toxicology, Sep 2007, Kaiserslautern, Germany
Conference poster hal-03757698v1

Major sulfation pathway for resveratrol metabolism in human hepatic derived cells and resveratrol –dependent inducibility of conjugating enzymes. Perspective in nutritional prevention

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel
2. congrès international Santé et Nutrition VITAGORA, Mar 2007, Dijon, France
Conference poster hal-03838598v1

Effects of estradiol on TCDD-induced oxidative stress in hepatoma cells

Manuela Goettel , Isabelle Séverin , Marie-Christine Chagnon , Dieter Schrenk
44. Congress of the European Societies of Toxicology, 2007/10/7-10, 2007, Amsterdam, Netherlands. , 2007, ⟨10.1016/j.toxlet.2007.05.578⟩
Conference poster hal-02821345v1

Major sulfation pathway for resveratrol metabolism in human hepatic derived cells and resveratrol –dependent inducibility of conjugating enzymes. Perspective in nutritional prevention

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel
European Partnership Meetings: Taste, Nutrition, Health, Jun 2007, Dijon, France
Conference poster hal-03838370v1

Endocrine disruptors found in food modulate estradiol cellular metabolism

Nathalie Hanet , Allan Lançon , Dominique Delmas , Brigitte Jannin , Marie-Christine Chagnon
1. congrès international Santé et Nutrition VITAGORA, Mar 2006, Dijon, France
Conference poster hal-03757366v1

Disposition and metabolic profiling of bisphénol F in pregnant and non pregnant rat

Nicolas J. Cabaton , Daniel Zalko , Jean-Pierre Cravedi , Marie-Christine Chagnon
Molecular Research in Environmental Medicine, 2. international conference, Sep 2006, Paris, France
Conference poster hal-03592921v1