Marie-Christine CHAGNON

129
Documents

Présentation

Parmi les nombreuses sources de contaminants potentiels des aliments, les substances emballages sont souvent incriminés. En effet, des substances chimiques présentes dans les matériaux au contact des denrées alimentaires (MCDA) peuvent migrer vers les aliments. Ces composés, retrouvés en très faibles quantités, peuvent cependant induire des modifications organoleptiques inacceptables, être toxiques par eux-mêmes ou par les produits générés. L’étude du danger que représente l'ensemble des substances capables de migrer de l'emballage vers l'aliment permet une meilleure évaluation de l'emballage fini.

Les effets toxiques potentiels des extraits des emballages finis peuvent donc être testés d’un point de vue toxicologique en utilisant des tests de screening in vitro, précoces, sensibles et spécifiques, dénommés « biotests ». Certains sont déjà utilisés pour les dossiers d’autorisation pour les substances intentionnelles. Les résultats des biotests peuvent être corrélés aux données analytiques afin d’identifier le ou les substances responsables. Si les données analytiques n’expliquent pas l’effet toxique observé, il peut être dû soit à une substance non identifiée dans le mélange, soit à un effet « cocktail ».

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Publications

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Risks to human and animal health from the presence of bromide in food and feed

Efsa Scientific Committee , Susanne Hougaard Bennekou , Ana Allende , Angela Bearth , Josep Casacuberta et al.
EFSA Journal, 2025, 23 (1), pp.1-164. ⟨10.2903/j.efsa.2025.9121⟩
Article dans une revue anses-04969003 v1

Hazard assessment of fenozan, a released non-intentionally added substance from polyester-based can coating

Ruzanna Hayrapetyan , Isabelle Séverin , Olga Matviichuk , Lorine da Costa , Cristina Juan et al.
Food additives & contaminants. Part A. Chemistry, analysis, control, exposure & risk assessment, 2024, Part A, pp.1-15. ⟨10.1080/19440049.2024.2414438⟩
Article dans une revue hal-04753824 v1

P01-34 Identification and toxicity assessment of volatile and semi-volatile non-intentionally added substances from polyester-based can coating

Ruzanna Hayrapetyan , Isabelle Séverin , Olha Matviichuk , Véronique Monneraye , Ronan Cariou et al.
Toxicology Letters, 2024, 399 (Supplement 2), pp.S85-S85. ⟨10.1016/j.toxlet.2024.07.225⟩
Article dans une revue hal-04703583 v1

Identification of non-volatile non-intentionally added substances from polyester food contact coatings and genotoxicity assessment of polyester coating's migrates

Ruzanna Hayrapetyan , Ronan Cariou , Anne Platel , Julie Santos , Ludovic Huot et al.
Food and Chemical Toxicology, 2024, 185 (1-3), pp.114484. ⟨10.1016/j.fct.2024.114484⟩
Article dans une revue hal-04431727 v1
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Cocktails of endocrine disruptors in the different diets of French consumers

Gaud Dervilly , Manon Bourdeau , Manon Pruvost-Couvreur , Isabelle Severin , Anne Platel et al.
Environment International, 2024, 183, pp.108408. ⟨10.1016/j.envint.2023.108408⟩
Article dans une revue hal-04401254 v1

Protective properties of the edible halophyte Carpobrotus edulis (L.) N.E.Br. towards neoformed food contaminants-related oxidative stress and genotoxicity

Daniela Oliveira , Ruzanna Hayrapetyan , Maria Inês Dias , Lillian Barros , Isabelle Séverin et al.
Food Bioscience, 2024, 61, pp.104447. ⟨10.1016/j.fbio.2024.104447⟩
Article dans une revue hal-04614106 v1

P25-06 PackSafe: Integrated chemical safety assessment of Food Contact Articles (ANR-21-CE21-0004 project: 2022–2025)

Marie-Christine Chagnon , Mai Phuong Nguyen , A. Pissis , Laurence Dahbi , Cédric Lyathaud et al.
Toxicology Letters, 2024, 399 (Supplement 2), pp.S355. ⟨10.1016/j.toxlet.2024.07.844⟩
Article dans une revue hal-04703614 v1
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Migration Studies and Endocrine Disrupting Activities: Chemical Safety of Cosmetic Plastic Packaging

Elias Bou-Maroun , Laurence Dahbi , Laurence Dujourdy , Pierre-Jacques Ferret , Marie-Christine Chagnon
Polymers, 2023, 15 (19), pp.4009. ⟨10.3390/polym15194009⟩
Article dans une revue hal-04253662 v1
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The cell transformation assay to assess potential carcinogenic properties of nanoparticles

Ruzanna Hayrapetyan , Théo Lacour , Luce Annette , Francis Finot , Marie-Christine Chagnon et al.
Mutation Research - Reviews, 2023, 791, pp.108455. ⟨10.1016/j.mrrev.2023.108455⟩
Article dans une revue hal-04044912 v1
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Stratégie pour une sécurité chimique intégrée des matériaux d’emballage au contact des denrées alimentaires

Isabelle Séverin , Laurence Dahbi , Sandra Domenek , Phuong-Mai Nguyen , Anne Platel et al.
Cahiers de Nutrition et de Diététique, 2023, 58 (2), pp.134-141. ⟨10.1016/j.cnd.2022.12.005⟩
Article dans une revue hal-03927663 v1

In vitro and in silico approach to study the hormonal activities of the alternative plasticizer tri-(2-ethylhexyl) trimellitate TEHTM and its metabolites

Laurence Dahbi , Amaury Farce , Nicolas Kambia , Isabelle Séverin , Thierry Dine et al.
Archives of Toxicology, 2022, 96, pp.899-918. ⟨10.1007/s00204-022-03230-4⟩
Article dans une revue hal-03546832 v1
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Epoxiconazole alters the histology and transcriptome of mouse liver in a transgenerational pattern

Ludovic Le Corre , Axelle Brulport , Daniel Vaiman , Marie-Christine Chagnon
Chemico-Biological Interactions, 2022, 360, pp.109952. ⟨10.1016/j.cbi.2022.109952⟩
Article dans une revue hal-03690009 v1

Development of a new methodology to determine size differences of nanoparticles with nanoparticle tracking analysis

Yann Pellequer , Gilbert Zanetta , Jean-Michel Rebibou , Isabelle Séverin , Marie-Christine Chagnon et al.
Applied Nanoscience, 2021, 11, pp.2129-2141. ⟨10.1007/s13204-021-01932-2⟩
Article dans une revue hal-03281325 v1
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Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies

Nicolas Kambia , Isabelle Séverin , Amaury Farce , Laurence Dahbi , Thierry Dine et al.
Metabolites, 2021, 11 (2), pp.94. ⟨10.3390/metabo11020094⟩
Article dans une revue hal-03141182 v1
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Transgenerational effects on intestinal inflammation status in mice perinatally exposed to bisphenol S

Axelle Brulport , Corinne Lencina , Marie-Christine Chagnon , Ludovic Le Corre , Laurence Guzylack-Piriou
Article dans une revue hal-02964984 v1
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Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet

Axelle Brulport , Ludovic Le Corre , Guillaume Maquart , Virginie Barbet , Aurélie Dastugue et al.
Environmental Pollution, 2021, 270, pp.116243. ⟨10.1016/j.envpol.2020.116243⟩
Article dans une revue hal-03148322 v1
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Hepatic transcriptome and DNA methylation patterns following perinatal and chronic BPS exposure in male mice

Axelle Brulport , Daniel Vaiman , Elias Bou-Maroun , Marie-Christine Chagnon , Ludovic Le Corre
BMC Genomics, 2020, 21 (1), pp.881. ⟨10.1186/s12864-020-07294-3⟩
Article dans une revue hal-03114886 v1
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Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver

Axelle Brulport , Daniel Vaiman , Marie-Christine Chagnon , Ludovic Le Corre
Chemosphere, 2020, 241, pp.125092. ⟨10.1016/j.chemosphere.2019.125092⟩
Article dans une revue hal-02325508 v1
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Lemon Juice, Sesame Paste, and Autoclaving Influence Iron Bioavailability of Hummus: Assessment by an In Vitro Digestion/Caco-2 Cell Model

Nour Doumani , Isabelle Séverin , Laurence Dahbi , Elias Bou-Maroun , Maya Tueni et al.
Foods, 2020, 9 (4), pp.474-494. ⟨10.3390/foods9040474⟩
Article dans une revue hal-02551705 v1
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FITNESS, première plateforme européenne sur l’emballage et le conditionnement des aliments

Antoine Kieffer , Catherine Loriot , Patrick P. Sauvegrain , Jean Mario Julien , Mai Nguyen et al.
IAA La revue des industries agroalimentaires, 2019, pp.24-26
Article dans une revue hal-02511722 v1
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Lebanese Population Exposure to Trace Elements via White Bread Consumption

Nada Lebbos , Claude Daou , Rosette R. Ouaini , Hanna H. Chebib , Michel Afram et al.
Foods, 2019, 8 (11), pp.574. ⟨10.3390/foods8110574⟩
Article dans une revue hal-02380322 v1
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In vitro and in silico hormonal activity studies of di-(2-ethylhexyl)terephthalate, a di-(2-ethylhexyl)phthalate substitute used in medical devices, and its metabolites

Nicolas Kambia , Isabelle Séverin , Amaury Farce , Emmanuel Moreau , Laurence Dahbi et al.
Journal of Applied Toxicology, 2019, 39, pp.1043-1056. ⟨10.1002/jat.3792⟩
Article dans une revue hal-02068658 v1

Genotoxic effects of food contact recycled paperboard extracts on two human hepatic cell lines.

Emilie Souton , Isabelle Séverin , Ludovic Le Hegarat , Kevin Hogeveen , Abdulhadi Aljawish et al.
Food additives & contaminants. Part A. Chemistry, analysis, control, exposure & risk assessment, 2018, 35 (1), pp.159-170. ⟨10.1080/19440049.2017.1397774⟩
Article dans une revue hal-01625970 v1

Are epigenetic modifications linked to BPS obesogen effect after perinatal exposure? Differential DNA methylation study in mouse livers

Axelle Brulport , Ludovic Le Corre , Daniel Vaiman , Marie-Christine Chagnon
Toxicology Letters, 2018, 295 (Supplement 1), pp.S132. ⟨10.1016/j.toxlet.2018.06.698⟩
Article dans une revue hal-01959924 v1

Chronic exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces an obesogenic effect in C57BL/6J mice fed a high fat diet

Axelle Brulport , Ludovic Le Corre , Marie-Christine Chagnon
Toxicology, 2017, 390, pp.43-52. ⟨10.1016/j.tox.2017.07.017⟩
Article dans une revue hal-01577444 v1
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In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line

Teuta Eljezi , Pierre Pinta , Damien Richard Richard , Jérémy Pinguet , Jean-Michel Chezal et al.
Chemosphere, 2017, 173, pp.452 - 459. ⟨10.1016/j.chemosphere.2017.01.026⟩
Article dans une revue inserm-01856278 v1

Chemical analysis and potential endocrine activities of aluminium coatings intended to be in contact with cosmetic water

Elias Bou-Maroun , Laurence Dahbi , Marie-Pierre Pierre , Philippine Pierre , Sandrine Rakotomalala et al.
Journal of Pharmaceutical and Biomedical Analysis, 2017, 145, pp.641 - 650. ⟨10.1016/j.jpba.2017.07.061⟩
Article dans une revue hal-01616383 v1

Use of bioassays to assess hazard of food contact material extracts: State of the art

Isabelle Séverin , Emilie Souton , Laurence Dahbi , Marie-Christine Chagnon
Food and Chemical Toxicology, 2017, 105, pp.429-447. ⟨10.1016/j.fct.2017.04.046⟩
Article dans une revue hal-01560265 v1
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In vitro toxicity assessment of extracts derived from sol–gel coatings on polycarbonate intended to be used in food contact applications

Isabelle Séverin , Krystelle Lionti , Laurence Dahbi , Catherine Loriot , Bérangère Toury et al.
Food and Chemical Toxicology, 2016, 93, pp.51 - 57. ⟨10.1016/j.fct.2016.04.025⟩
Article dans une revue hal-01434899 v1
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The consequences of physical post-treatments (microwave and electron-beam) on food/packaging interactions: A physicochemical and toxicological approach

Anne-Marie Riquet-Motchidlover , Colette Breysse , Laurence Dahbi , Catherine Loriot , Isabelle Séverin et al.
Food Chemistry, 2016, 199, pp.59-69. ⟨10.1016/j.foodchem.2015.09.034⟩
Article dans une revue hal-01243319 v1
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Obesogen effects after perinatal exposure of 4,4′-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice

L. Ivry del Moral , Ludovic Le Corre , Hélène Poirier , Isabelle Niot , T. Truntzer et al.
Toxicology, 2016, 357-358, pp.11 - 20. ⟨10.1016/j.tox.2016.05.023⟩
Article dans une revue hal-01431231 v1

Use of reliable bioassays to detect potential hazard of food contact materials extracts to ensure quality, safety and innovation of paperboards

Emilie Souton , Isabelle Séverin , Marie-Christine Chagnon
Toxicology Letters, 2015, Toxicology Letters, 238 (2, supplément), pp.S1-420
Article dans une revue hal-03611999 v1

Migration of plasticizers from PVC medical devices: Development of an infusion model.

Lise Bernard , R. Cueff , Marie-Christine Chagnon , F. Abdoulouhab , Bertrand Décaudin et al.
International Journal of Pharmaceutics, 2015, 494 (1), pp.136-145. ⟨10.1016/j.ijpharm.2015.08.033⟩
Article dans une revue hal-03611985 v1

BPA, an Energy Balance Disruptor

Ludovic Le Corre , Philippe Besnard , Marie-Christine Chagnon
Critical Reviews in Food Science and Nutrition, 2014, 55 (6), pp.769-777. ⟨10.1080/10408398.2012.678421⟩
Article dans une revue hal-01960190 v1

Estrogen receptor α and aryl hydrocarbon receptor cross-talk in a transfected hepatoma cell line (HepG2) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Manuela Göttel , Ludovic Le Corre , Coralie Dumont , Dieter Schrenk , Marie-Christine Chagnon
Toxicology Reports, 2014, 1, pp.1029-1036. ⟨10.1016/j.toxrep.2014.09.016⟩
Article dans une revue hal-01960137 v1

P019: Effet obésogène des bisphénols A et S chez la souris C57Bl/6

L. Ivry-del Moral , Ludovic Le Corre , Kévin Gaire , Cécile Héliès-Toussaint , Hélène Poirier et al.
Nutrition Clinique et Métabolisme, 2014, 28, ⟨10.1016/S0985-0562(14)70662-4⟩
Article dans une revue hal-01915989 v1

In vitro genotoxicity assessment of MTES, GPTES and TEOS, three precursors intended for use in food contact coatings

Krystelle Lionti , Isabelle Séverin , Laurence Dahbi , Bérangère Toury , Marie-Christine Chagnon
Food and Chemical Toxicology, 2014, 65, pp.76-81. ⟨10.1016/j.fct.2013.11.037⟩
Article dans une revue hal-01962377 v1

Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: A focus on their potential involvement in nonalcoholic fatty liver disease

Ludovic Peyre , Patrick Rouimi , Georges de Sousa , Cécile Héliès-Toussaint , Benjamin Carre et al.
Food and Chemical Toxicology, 2014, 70, pp.9 - 18. ⟨10.1016/j.fct.2014.04.011⟩
Article dans une revue hal-02638648 v1

Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study

Cécile Héliès-Toussaint , Ludovic Peyre , Claudia Costanzo , Marie-Christine Chagnon , Roger Rahmani
Toxicology and Applied Pharmacology, 2014, 280 (2), pp.224-235. ⟨10.1016/j.taap.2014.07.025⟩
Article dans une revue hal-02641516 v1

Effect of sunlight exposure on the release of intentionally and/or non-intentionally added substances from polyethylene terephthalate (PET) bottles into water: Chemical analysis and in vitro toxicity

Cristina Bach , Xavier Dauchy , Isabelle Séverin , Jean-Francois Munoz , Serge Etienne et al.
Food Chemistry, 2014, 162, pp.63-71. ⟨10.1016/j.foodchem.2014.04.020⟩
Article dans une revue hal-01296979 v1

Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells

Micheline Dsamou , Martine Morzel , Ludovic Le Corre , Isabelle Séverin , Marie-Christine Chagnon
Archives of Oral Biology, 2013, 58 (10), pp.1511-1516. ⟨10.1016/j.archoralbio.2013.06.005⟩
Article dans une revue istex hal-01960219 v1

Effet obésogène du bisphénol A sur des souris C57Bl/6 sous régime hyperlipidique

Ludovic Le Corre , Lydie Ivry-del Moral , Philippe Besnard , Marie-Christine Chagnon
Cahiers de Nutrition et de Diététique, 2013, 48 (3), pp.129-136. ⟨10.1016/j.cnd.2013.02.003⟩
Article dans une revue hal-01961507 v1

Effect of temperature on the release of intentionally and non-intentionally added substances from polyethylene terephthalate (PET) bottles into water: Chemical analysis and potential toxicity

Cristina Bach , Xavier Dauchy , Isabelle Séverin , Jean-François Munoz , Serge Etienne et al.
Food Chemistry, 2013, 139 (1-4), pp.672 - 680. ⟨10.1016/j.foodchem.2013.01.046⟩
Article dans une revue istex anses-01903693 v1
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Salivary protein profiles and sensitivity to the bitter taste of caffeine.

Micheline Dsamou , Olivier Palicki , Chantal Septier , Claire Chabanet , Géraldine Lucchi et al.
Chemical Senses, 2012, 37 (1), pp.87-95. ⟨10.1093/chemse/bjr070⟩
Article dans une revue hal-00723339 v1

Bisphenol A disrupts the intestinal lipid metabolism

Ludovic Le Corre , Lydie Ivry Del Moral , Philippe Besnard , Marie-Christine Chagnon
Toxicology Letters, 2012, 211, pp.S210. ⟨10.1016/j.toxlet.2012.03.753⟩
Article dans une revue istex hal-01961543 v1
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Chemical migration in drinking water stored in polyethylene terephthalate (PET) bottles: a source of controversy reviewed

Cristina Bach , Xavier Dauchy , Marie-Christine Chagnon , Serge Etienne
Water Research, 2012, 46 (3), pp. 571-583. ⟨10.1016/j.watres.2011.11.062⟩
Article dans une revue hal-00683918 v1

In-mouth mechanisms leading to flavor release and perception.

Christian Salles , Marie-Christine Chagnon , Gilles Feron , Elisabeth Guichard , Hélène Labouré et al.
Critical Reviews in Food Science and Nutrition, 2011, 51 (1), pp.67-90. ⟨10.1080/10408390903044693⟩
Article dans une revue hal-00823384 v1

Cross talk between nuclear receptor ERalpha ET AhR in human hepatoma cell line (HepG2) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Manuela Goettel , Ludovic Le Corre , Isabelle Séverin , Dieter Schrenk , Marie-Christine Chagnon
Toxicology Letters, 2011, Abstracts of the 47th Congress of the European Societies of Toxicology (EUROTOX), 205, pp.S239-S239. ⟨10.1016/j.toxlet.2011.05.817⟩
Article dans une revue istex hal-00722931 v1

Bisphenol a exposure in C57Bl/6 mice fed with a high fat diet

Ludovic Le Corre , Philippe Besnard , Marie-Christine Chagnon
Toxicology Letters, 2011, 205 (Supplement), pp.S143-S143. ⟨10.1016/j.toxlet.2011.05.508⟩
Article dans une revue istex hal-00723043 v1

Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes

Coralie Dumont , Elisabeth Perdu , Georges de Sousa , Laurent Debrauwer , Roger Rahmani et al.
Drug and Chemical Toxicology, 2011, 34 (4), pp.445-453. ⟨10.3109/01480545.2011.585651⟩
Article dans une revue hal-02651168 v1

Developmental toxic potential of di-n-propyl phthalate administered orally to rats.

Anne-Marie Saillenfait , Alain-Claude Roudot , Frédéric Gallissot , Jean-Philippe Sabaté , Marie-Christine Chagnon
Journal of Applied Toxicology, 2011, 31 (1), pp.36-44. ⟨10.1002/jat.1565⟩
Article dans une revue istex hal-00723070 v1

Risk assessment and management–Food contact materials

Isabelle Séverin , Anne-Marie Riquet , Marie-Christine Chagnon
Cahiers de Nutrition et de Diététique, 2011, 46 (2), pp.59-66. ⟨10.1016/j.cnd.2010.11.003⟩
Article dans une revue hal-01962438 v1

Genotoxic activities of the food contaminant 5-hydroxymethylfurfural using different in vitro bioassays

Isabelle Séverin , Coralie Dumont , Adeline Jondeau-Cabaton , Vanessa Graillot , Marie-Christine Chagnon
Toxicology Letters, 2010, 192 (2), pp.189-194. ⟨10.1016/j.toxlet.2009.10.022⟩
Article dans une revue istex hal-00850790 v1
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Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro

François Chauvigné , Arnaud Menuet , Laurianne Lesné , Marie-Christine Chagnon , Cécile Chevrier et al.
Environmental Health Perspectives, 2009, 117 (4), pp.515-21. ⟨10.1289/ehp.11870⟩
Article dans une revue hal-00669512 v1

Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line

Nicolas J. Cabaton , Coralie Dumont , Isabelle Séverin , Elisabeth Perdu , Daniel Zalko et al.
Toxicology, 2009, 255 (1-2), pp.15-24. ⟨10.1016/j.tox.2008.09.024⟩
Article dans une revue istex hal-01962644 v1

Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines

Céline Gasnier , Coralie Dumont , Nora Benachour , Emilie Clair , Marie-Christine Chagnon et al.
Toxicology, 2009, 262 (3), pp.184-191. ⟨10.1016/j.tox.2009.06.006⟩
Article dans une revue istex hal-03426636 v1

Transferts de matière au travers des emballages au contact de produits alimentaires

Anne Endrizzi , Thomas Karbowiak , Frédéric Debeaufort , David Chassagne , Marie-Christine Chagnon et al.
Industries Alimentaires et Agricoles, 2009, 2009-009/010, pp.11-16
Article dans une revue hal-03565946 v1

Biotransformation of bisphenol F by human and rat liver subcellular fractions

Nicolas J. Cabaton , Daniel Zalko , Estelle Rathahao-Paris , Cécile Canlet , Georges Delous et al.
Toxicology in Vitro, 2008, 22 (7), pp.1697-1704. ⟨10.1016/j.tiv.2008.07.004⟩
Article dans une revue istex hal-01173776 v1

Effects of endocrine disruptors on genes associated with 17 beta-estradiol metabolism and excretion

Nathalie Hanet , Allan Lancon , Dominique Delmas , Brigitte Jannin , Marie-Christine Chagnon et al.
Steroids, 2008, 73 (12), pp.1242-1251. ⟨10.1016/j.steroids.2008.06.005⟩
Article dans une revue istex hal-02662141 v1
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Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes.

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel et al.
Drug Metabolism and Disposition, 2007, 35 (5), pp.699-703. ⟨10.1124/dmd.106.013664⟩
Article dans une revue hal-00259260 v1

Effect of in utero exposure to di-(2-ethylhexyl)phthalate: Distribution in the rat fetus and testosterone production by rat fetal testis in culture

Thomas Stroheker , Jean-François Regnier , Julie Lassurguère , Marie-Christine Chagnon
Food and Chemical Toxicology, 2006, 44 (12), pp.2064-2069. ⟨10.1016/j.fct.2006.07.007⟩
Article dans une revue istex hal-02664478 v1
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Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants

Adeline Jondeau , Laurence Dahbi , Marie-Helene Bani-Estivals , Marie-Christine Chagnon
Toxicology, 2006, 226 (2-3), pp.218-228. ⟨10.1016/j.tox.2006.07.007⟩
Article dans une revue hal-00294427 v1

Disposition and metabolic profiling of bisphenol F in pregnant and nonpregnant rats

Nicolas J. Cabaton , Marie-Christine Chagnon , Jean-Claude Lhuguenot , Jean Pierre J. P. Cravedi , Daniel Zalko
Journal of Agricultural and Food Chemistry, 2006, 54 (26), pp.10307-10314. ⟨10.1021/jf062250q⟩
Article dans une revue istex hal-02668619 v1

2,4-Diaminotoluene (2,4-DAT)-induced DNA damage, DNA repair and micronucleus formation in the human hepatoma cell line HepG2

Isabelle Séverin , Adeline Jondeau , Laurence Dahbi , Marie-Christine Chagnon
Toxicology, 2005, 213 (1-2), pp.138-146. ⟨10.1016/j.tox.2005.05.021⟩
Article dans une revue istex hal-01981435 v1

Pharmacokinetic and metabolism of apigenin in female and male rats after a single oral administration

Angeline Gradolatto , Jean-Philippe Basly , Raymond Bergès , Caroline Teyssier , Marie-Christine Chagnon et al.
Drug Metabolism and Disposition, 2005, 33 (1), pp.49-54. ⟨10.1124/dmd.104.000893⟩
Article dans une revue hal-02677921 v1

Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate

Thomas Stroheker , Nicolas Cabatona , Gorian Nourdin , Jean-François Regnier , Jean-Claude Lhuguenota et al.
Toxicology, 2005, 208 (1), pp.115-121. ⟨10.1016/j.tox.2004.11.013⟩
Article dans une revue istex hal-02680300 v1

Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines

T. Stroheker , K. Picard , J.C. Lhuguenot , Marie-Chantal Canivenc-Lavier , Marie-Christine Chagnon
Food and Chemical Toxicology, 2004, 42, pp.887-897
Article dans une revue hal-02679474 v1

Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis

D. Guyonnet , Raymond Bergès , M.H. Siess , M.F. Pinnert , Marie-Christine Chagnon et al.
Food and Chemical Toxicology, 2004, 42 (9), pp.1479-1485
Article dans une revue hal-02677820 v1

The autoradiographic test for unscheduled DNA synthesis : a sensitive assay for the detection of DNA repair in the HepG2 cell line

Isabelle Valentin-Severin , V. Thybaud , A.M. Lebon , J.C. Lhuguenot , Marie-Christine Chagnon
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2004, 559, pp.211-217
Article dans une revue hal-02672058 v1

Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis

D. Guyonnet , Raymond Bergès , M.H. Siess , M.F. Pinnert , Marie-Christine Chagnon et al.
Food and Chemical Toxicology, 2004, 42, pp.1479-1485
Article dans une revue hal-02679472 v1

The autoradiographic test for unscheduled DNA synthesis: a sensitive assay for the detection of DNA repair in the HepG2 cell line

Isabelle Valentin-Severin , Véronique Thybaud , Anne-Marie Le Bon , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2004, 559 (1-2), pp.211-217. ⟨10.1016/j.mrgentox.2003.12.007⟩
Article dans une revue istex hal-01981453 v1

Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats : a comparative study

Thomas Stroheker , Marie-Christine Chagnon , Marie-France Pinnert , Raymond Bergès , Marie-Chantal Canivenc-Lavier
Reproductive Toxicology, 2003, 17 (4), pp.421-432
Article dans une revue hal-02679922 v1
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Influence of dietary soy isoflavones on the accessory sex organs of the Wistar rat

Thomas Stroheker , Nicolas J. Cabaton , Raymond Berges , Valérie Lamothe , Jean-Claude Lhuguenot et al.
Food and Chemical Toxicology, 2003, 41 (8), pp.1175-83. ⟨10.1016/S0278-6915(03)00108-X⟩
Article dans une revue hal-02681581 v1

Use of HepG2 cell line for direct or indirect mutagens screening : comparative investigation between comet and micronucleus assays

Isabelle Valentin-Severin , L. Le Hagarat , J.C. Lhuguenot , A.M. Lebon , Marie-Christine Chagnon
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2003, 536, pp.79-90
Article dans une revue hal-02680011 v1

Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.

Isabelle Valentin-Severin , Ludovic Le Hegarat , Jean-Claude Lhuguenot , Anne-Marie Le Bon , Marie-Christine Chagnon
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2003, 536 (1-2), pp.79-90. ⟨10.1016/S1383-5718(03)00031-7⟩
Article dans une revue istex hal-01981654 v1

Toxic interaction between hydroxyurea and 1-beta-D-arabino-furanosylcytosine on the DNA of a human hepatoma cell line (HEPG2).

Isabelle Séverin , Martine Padieu , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Toxicology Letters, 2003, 145 (3), pp.303-11. ⟨10.1016/j.toxlet.2003.08.003⟩
Article dans une revue istex hal-01981468 v1

Uridine uptake inhibition assay: an automated micromethod for the screening of cytotoxicity.

Isabelle Valentin-Severin , Laurence Laignelet , Jean Claude Lhuguenot , Marie-Christine Chagnon
Toxicology, 2002, 171 (2-3), pp.207-13. ⟨10.1016/S0300-483X(01)00587-X⟩
Article dans une revue istex hal-01981698 v1

Estrogenic activity and metabolism of N-butyl benzyl phtalate in vitro : identification of the active molecule(s)

K. Picard , J.C. Lhuguenot , Marie-Chantal Canivenc-Lavier , Marie-Christine Chagnon
Toxicology and Applied Pharmacology, 2001, 172, pp.108-118
Article dans une revue hal-02675409 v1
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Uridine uptake inhibition as a cytotoxicity test for a human hepatoma cell line (HepG2 cells): comparison with the neutral red assay

Isabelle Valentin , Murielle Philippe , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Toxicology, 2001, 158, pp.127-139
Article dans une revue hal-01981819 v1
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Metabolism of N-Butyl Benzyl Phthalate in the Female Wistar Rat. Identification of New Metabolites

C Nativelle , K Picard , Isabelle Valentin , Jean-Claude C Lhuguenot , Marie-Christine Chagnon
Food and Chemical Toxicology, 1999, 37, pp.905-917
Article dans une revue hal-01981781 v1

Metabolism of N-butyl benzyl phtalate in the female wistar rat. Identification of new metabolites

C. Nativelle , K. Picard , Isabelle Valentin , J.C. Lhuguenot , Marie-Christine Chagnon
Food and Chemical Toxicology, 1999, 37, pp.905-917
Article dans une revue hal-02694753 v1

P XIX.9 Migration and mutagenic potentiality of food contact materials: A new strategy for testing their safety

Isabelle Leguy , Anne-Marie Le Bon , Christine Belloir , Jean-Claude Lhuguenot , Marie-Christine Chagnon
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1997, 379 (1), pp.S198-S199. ⟨10.1016/S0027-5107(97)83306-4⟩
Article dans une revue istex hal-03978096 v1

Fenofibrate: Metabolism and Species Differences for Peroxisome Proliferation in Cultured Hepatocytes

Marie-Christine Chagnon , H Dupont , A Edgar
Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, 26 (1), pp.63-74. ⟨10.1006/faat.1995.1075⟩
Article dans une revue hal-03978100 v1
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Ascorbic acid uptake by isolated rat hepatocytes: Stimulatory effect of diquat, a redox cycling compound

Marie-Christine Chagnon , Gregory Adam Moore , Yoshio Nakagawa , Peter Moldéus
Biochemical Pharmacology, 1993, 46 (8), pp.1333-1338. ⟨10.1016/0006-2952(93)90096-f⟩
Article dans une revue hal-03978103 v1

Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid

Y. Keith , Marie-Christine Chagnon , P. Canning , J. Foster , Jean-Claude Lhuguenot et al.
Archives of Toxicology, 1992, 66 (5), pp.321-326. ⟨10.1007/BF01973626⟩
Article dans une revue hal-03978113 v1

Identification of the proximate peroxisome proliferator(S) derived from DI (2-ethylhexyl) adipate and species differences in response

Marie-Christine Chagnon , Jean-Claude Lhuguenot , A.M. Brady , R. Moore , C.R. Elcombe
Biochemical Pharmacology, 1992, 43 (10), pp.2129-2134. ⟨10.1016/0006-2952(92)90171-e⟩
Article dans une revue hal-03978116 v1

In vivo and in vitro metabolism of di-(2 ethylhexyl) adipate, a peroxisome proliferator in the rat

Marie-Christine Chagnon , Y. Keith , C. Elcombe , Jean-Claude Lhuguenot
Archives of Toxicology, 1988, Archives of Toxicology, 12, pp.265-268. ⟨10.1007/978-3-642-73113-6_43⟩
Article dans une revue hal-03978151 v1

Di-(2-ethylhexyl) Adipate and Peroxisome Proliferation: Identification of Proximate Peroxisomal Proliferator In Vivo and In Vitro

Y. Keith , Marie-Christine Chagnon , C. Elcombe , Jean-Claude Lhuguenot
Archives of Toxicology, 1988, Archives of Toxicology, 12, pp.274-277. ⟨10.1007/978-3-642-73113-6_45⟩
Article dans une revue hal-03978126 v1

P03-04: Safety evaluation of can's polyester coatings using and approaches

Ruzanna Hayrapetyan , Isabelle Séverin , Ronan Cariou , Marie-Christine Chagnon
57th Congress of the European-Societies-of-Toxicology (EUROTOX), Sep 2023, Ljubljana, Slovenia. pp.S84, ⟨10.1016/S0378-4274(23)00468-X⟩
Communication dans un congrès hal-04279594 v1

P22-05 Identification and hazard assessment of oligoesters, nonintentionally added substances present in food contact coating extracts

Ruzanna Hayrapetyan , Isabelle Séverin , V. Monneraye , R. Cariou , Marie-Christine Chagnon
16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Sep 2022, Maastricht, Netherlands. pp.S271-S271, ⟨10.1016/j.toxlet.2022.07.719⟩
Communication dans un congrès hal-03948279 v1

Risk assessment of endocrine-disrupting cocktail effect from multiexposure to plasticizers of medical devices in the neonatal population

Lise Bernard , Marie-Christine Chagnon , Laurence Dahbi , Valérie Sautou
15th International Congress of Toxicology, Sep 2022, Maastricht, Netherlands
Communication dans un congrès hal-04066086 v1

Risk assessment of endocrine-disrupting cocktail effect from multiexposure to plasticizers of medical devices in the neonatal population

L. Bernard , Laurence Dahbi , Marie-Christine Chagnon , Valérie Sautou
16th International Congress of Toxicology (ICT) - Uniting in Toxicology, Sep 2022, Maastricht, Netherlands. pp.S76-S76, ⟨10.1016/j.toxlet.2022.07.225⟩
Communication dans un congrès hal-04007388 v1

Chemical analysis of metallic trace elements of toxicological concern in Lebanese pita and risk characterization for the consumers

N. Lebbos , Elias Bou-Maroun , C. Daou , R. Ouaini , H. Chebib et al.
54. Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, Sep 2018, Bruxelles, Belgium. ⟨10.1016/j.toxlet.2018.06.791⟩
Communication dans un congrès hal-02733845 v1

Etude du métabolisme in vitro du bisphénol F

Nicolas J. Cabaton , Elisabeth Perdu , Estelle Rathahao-Paris , Cécile Canlet , Jean-Pierre Cravedi et al.
Colloque ARET 2007, Jun 2007, Maisons-Alfort, France
Communication dans un congrès hal-03757609 v1

Bisphenol S is obesogen in male mice after perinatal exposure

Marie-Christine Chagnon , Lydie Ivry-del Moral , Ludovic Le Corre , Roger Rahmani
51. Congress of the European-Societies-of-Toxicology (EUROTOX), European Societies of Toxicology (EUROTOX)., Sep 2015, Porto, Portugal. 1 p., ⟨10.1016/j.toxlet.2015.08.1058⟩
Communication dans un congrès hal-02741257 v1

FP7: The Human Submandibular Gland (HSG) cell line: a tool to study the regulation of salivary markers of bitterness perception

Micheline Dsamou , Martine Morzel , Marie-Christine Chagnon
Food Oral Processing: Physics, Physiology, and Psychology of Eating. Session 7: In-mouth biological mechanisms at the origin of sensory perception, Jul 2012, Beaune, France. 1 p
Communication dans un congrès hal-00723343 v1

Effects of genistein, vinclozolin and BPA on the proliferation and differentiation of a human salivary cell line – CIME project

Laurence Dhabi , Isabelle Séverin , Marie-Chantal Canivenc-Lavier , Marie-Christine Chagnon
Colloque PNR-PE , Dec 2012, Paris, France. 1 p
Communication dans un congrès hal-01594399 v1

CIME: An integrative and multidisciplinary PNR-PE project on Chronic Impact of ED Mixture Exposure at environmental low doses on Reproduction, Development and Behavior

Marie-Chantal Canivenc-Lavier , Martine Applanat , Thuy-Anh Auxiètre , Sylvie Babajko , Ariane Berdal et al.
Colloque PNR-PE, Dec 2012, Paris, France. 1 p
Communication dans un congrès hal-01595174 v1

Food contact materials: Strategy for quality and food safety of packaging systems

Isabelle Séverin , Laurence Dahbi , Catherine Bergès , Coralie Dumont , Marie-Christine Chagnon
47. Congress of the European-Societies-of-Toxicology, Aug 2011, Paris, France. 2 p., ⟨10.1016/j.toxlet.2011.05.732⟩
Communication dans un congrès istex hal-02749456 v1

Sensitivity to bitterness: may in-mouth proteolysis be involved?

Micheline Dsamou , Olivier Palicki , Chantal Septier , Claire Chabanet , Géraldine Lucchi et al.
9. Pangborn sensory science symposium, Sep 2011, Toronto, Canada. 1 p
Communication dans un congrès hal-01594410 v1
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Mechanism of TCDD-induced oxidative stress, role of estrogen receptor, and modulation by estradiol in liver cells

Manuela Göttel , Marie-Christine Chagnon , Dieter Schrenk
49. Annual Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mar 2008, Mainz, Germany. pp.88
Communication dans un congrès hal-03426732 v1

Identification of genotoxic and endocrine disruption activities of 4,4’-dihydroxydiphenyl-methane (BPF) and its metabolites using human cell lines

N J Cabaton , Coralie Dumont , Isabelle Séverin , Daniel Zalko , Marie-Christine Chagnon
Congrès Annuel de la Société Française de toxicologie, Oct 2007, Montpellier, France
Communication dans un congrès hal-03593237 v1

Use of bcl2 stably transfected HepG2 cell line to improve the specificity of the comet assay

Isabelle Séverin , Marie-Odile Eichler , Laurence Dahbi , Marie-Christine Chagnon
Molecular Research in Environmental Medicine, 2. international conference, Sep 2006, Paris, France
Communication dans un congrès hal-03592899 v1
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Effet perturbateur endocrinien de l’apigénine chez le rat femelle immature

Thomas Stroheker , Angeline Gradolatto , Marie-France Pinnert , Caroline Teyssier , Marie-Christine Chagnon et al.
21e forum de cancérologie, Jun 2001, Paris, France. 1 p
Communication dans un congrès hal-02833937 v1

Strategy using a combination of physico/chemical analysis and in vitro bioassays for chemical safety of food contact articles

Isabelle Séverin , Laurence Dahbi , Sandra Domenek , Phuong-Mai Nguyen , Anne Platel et al.
RiskTOX 2023, Nov 2023, Valencia (Espagne), Spain
Poster de conférence hal-04375350 v1
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Could CTA be a reliable alternative method to identify non-genotoxic substances in Food Contact Material extract ?

Théo Lacour , Ruzanna Hayrapetyan , Isabelle Séverin , Isabelle Mouche , Francis Finot et al.
ICT 2022 The XVIth International Congress of Toxicology, Sep 2022, Maastricht, Netherlands. , 368, pp.S141, 2022, ⟨10.1016/j.toxlet.2022.07.402⟩
Poster de conférence hal-03819008 v1
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Lebanese pita extracts with presence of trace elements: hazard assessment

Isabelle Séverin , Elias Bou-Maroun , Rita Akiki , Ghiwa Zoghbi , Nada Lebbos et al.
47th Meeting of the European Environmental Mutagenesis and Genomics Society (EEMGS), May 2019, Rennes, France. ⟨10.13140/RG.2.2.30583.88489⟩
Poster de conférence hal-02296298 v1
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Extraction d'éléments traces métalliques à partir de pains libanais et évaluation du danger de ces mélanges

Isabelle Séverin , N. Lebbos , Elias Bou-Maroun , C. Daou , R. Ouaini et al.
SFT 2018, 2018, Dijon, France
Poster de conférence hal-01986057 v1

Metallic contamination of wheat-cultivated soils in the Bekaa flatland of Lebanon

N. Lebbos , Elias Bou-Maroun , R. Daou , H. Ouaini , H. Chebib et al.
Proceedings of the 14th International Conference on the Biogeochemistry of Trace Elements (ICOBTE), Jul 2017, Zürich, Switzerland
Poster de conférence hal-03556335 v1
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Genotoxicity assessment of a polycarbonate sol-gel coating and its precursors intended to be used for food contact

Isabelle Séverin , K. Lionti , Laurence Dahbi , C. Loriot , Bérangère Toury et al.
2016 ILSI Annual Meeting, Jan 2016, St. Petersburg, Fl, United States.
Poster de conférence hal-01989582 v1
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Reliable bioassays to detect potential hazard of paperboard food contact material extracts

Emilie Souton , Laurence Dahbi , Thomas Nury , Abdulhadi Aljawish , Isabelle Séverin et al.
European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016
Poster de conférence hal-01989751 v1
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In vitro hazard assessment of nanoparticles developed for biomedical applications

Annette Luce , Y Saibi , Isabelle Séverin , Julien Boudon , Nadine Millot et al.
European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016
Poster de conférence hal-01986190 v1
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Use of reliable bioassays to detect potential hazard of food contact materials extracts to ensure quality, safety and innovation of paperboards

Emilie Souton , Isabelle Séverin , Marie-Christine Chagnon
51st Congress of the European Societies of Toxicology (EUROTOX), Sep 2015, Porto, Portugal. 51st Congress of the European Societies of Toxicology (EUROTOX), 238 (2, supplément), pp.S348, 2015, Toxicology Letters
Poster de conférence hal-01985967 v1

Effects of Bisphenol A and its substitutes on the proliferation and differentiation in Caco-2 intestine cell model: MELBA project.

L. Ivry-del Moral , Laurent Le Corre , Roger Rahmani , Cécile Héliès-Toussaint , Marie-Christine Chagnon
PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012
Poster de conférence hal-02809669 v1

Le BPS, une bonne alternative au BPA ? Effets métaboliques du BPA et du BPS dans les hépatocytes et les adipocytes - Projet MELBA

Claudia Costanzo , Patrick Rouimi , Georges de Sousa , Marie-Christine Chagnon , Roger Rahmani et al.
PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012
Poster de conférence hal-02806503 v1

An integrative and multidisciplinary PNR-PE project for studying Chronic Impact of ED Mixture Exposures at environmental low doses on reproduction, development and behavior.

Marie-Chantal Canivenc-Lavier , M Applanat , Ta Auxiètre , S Babajko , A Berdal et al.
PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012
Poster de conférence hal-02807429 v1
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Salivary proteome and sensitivity to bitterness

Micheline Dsamou , Olivier Palicki , Chantal Septier , Isabelle Séverin , Marie-Christine Chagnon et al.
5. Congrès international goût-nutrition-santé, Mar 2010, Dijon, France. 1 p., 2010
Poster de conférence hal-01137080 v1

Major sulfation pathway for resveratrol metabolism in human hepatic derived cells and resveratrol –dependent inducibility of conjugating enzymes. Perspective in nutritional prevention

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel et al.
European Partnership Meetings: Taste, Nutrition, Health, Jun 2007, Dijon, France
Poster de conférence hal-03838370 v1

Effects of estradiol on TCDD-induced oxidative stress in hepatoma cells

Manuela Goettel , Isabelle Séverin , Marie-Christine Chagnon , Dieter Schrenk
44. Congress of the European Societies of Toxicology, 2007/10/7-10, 2007, Amsterdam, Netherlands. , 2007, ⟨10.1016/j.toxlet.2007.05.578⟩
Poster de conférence istex hal-02821345 v1

Endocrine disruptors found in food modulate estradiol cellular metabolism

Nathalie Hanet , Allan Lançon , Jean-Marie Heydel , Dominique Delmas , Brigitte Jannin et al.
2. congrès international Santé et Nutrition VITAGORA, Mar 2007, Dijon, France
Poster de conférence hal-03757959 v1

Major sulfation pathway for resveratrol metabolism in human hepatic derived cells and resveratrol –dependent inducibility of conjugating enzymes. Perspective in nutritional prevention

Allan Lançon , Nathalie Hanet , Brigitte Jannin , Dominique Delmas , Jean-Marie Heydel et al.
2. congrès international Santé et Nutrition VITAGORA, Mar 2007, Dijon, France
Poster de conférence hal-03838598 v1

Effects of estradiol on TCDD-induced oxidative stress in liver cells

Manuela Goettel , Marie-Christine Chagnon , Dieter Schrenk
symposium Food chemistry and toxicology, Sep 2007, Kaiserslautern, Germany
Poster de conférence hal-03757698 v1

Endocrine disruptors found in food modulate estradiol cellular metabolism

Nathalie Hanet , Allan Lançon , Dominique Delmas , Brigitte Jannin , Marie-Christine Chagnon et al.
1. congrès international Santé et Nutrition VITAGORA, Mar 2006, Dijon, France
Poster de conférence hal-03757366 v1

Disposition and metabolic profiling of bisphénol F in pregnant and non pregnant rat

Nicolas J. Cabaton , Daniel Zalko , Jean-Pierre Cravedi , Marie-Christine Chagnon
Molecular Research in Environmental Medicine, 2. international conference, Sep 2006, Paris, France
Poster de conférence hal-03592921 v1