Martine Gilleron

Chercheur CNRS
64%
Libre accès
114
Documents
Affiliation actuelle
  • Institut de pharmacologie et de biologie structurale (IPBS)
Contact

Domaines de recherche

Biologie structurale [q-bio.BM]

Compétences

Lipidomique Biochimie RMN Analyse structurale

Publications

Publications

Identifying lysosomal proteins involved in Mycobacterium tuberculosis lipid antigen presentation by CD1b

Sonia Belkai , Sophie Zuberogoïtia , Alain Vercellone , Isabelle Vergne , Alexandre Stella et al.
EMBO WORKSHOP PATHOGEN IMMUNITY AND SIGNALING, Apr 2025, SAN SERVOLO ISLAND, Italy
Poster de conférence hal-05023317 v1

Does Mycobacterium tuberculosis produce even more immunomodulatory lipids? Contribution of an unbiased lipidomic approach

Tamara Mickova , Jérôme Nigou , Martine Gilleron , Emilie Layre
EMBO Workshop Pathogen immunity and signaling, Apr 2024, San Servolo Venice, Italy
Poster de conférence hal-05024266 v1

Processing of microbial glycolipids in lysosome expands the repertoire of TLR2 agonists

Christophe Carrat , Sonia Belkai , Emilie Layre , Diane Cala - de Paepe , Landry Blanc et al.
18th GERLI Lipidomics meeting entitled "Lipids, from molecular aspects to human diseases", Oct 2023, Paris, France
Poster de conférence hal-05023349 v1

A Mycobacterium tuberculosis lipid fingerprint in human breath allows tuberculosis detection

Sergio Fabián Mosquera-Restrepo , Sophie Zuberogoïtia , Lucie Gouxette , Emilie Layre , Martine Gilleron et al.
GERLI 18th International lipidomics meeting “Tailored lipids: from molecular asopects to human diseases”, Oct 2023, Paris, France
Poster de conférence hal-05024147 v1

Guinea pig PIM-specific, CD1-restricted T cells contribute to granuloma integrity and immune protection against virulent M. tuberculosis

Emmelie Eckhardt , Jan Schinkoethe , Jens Peter Teifke , Marcel Gischke , Dirk Albrecht et al.
Global Forum on TB Vaccines, New horizons for TB vaccines, Feb 2021, Toulouse, France
Poster de conférence hal-05024619 v1

Deciphering lysosomal enzymatic activities involved in the processing of mycobacterial antigenic glycolipids

Sonia Belkai , Christophe Carrat , Charlotte Dessaux , Alexandre Stella , Odile Burlet-Schiltz et al.
Global Forum on TB Vaccines, New horizons for TB vaccines, Feb 2021, Toulouse, France
Poster de conférence hal-05023358 v1

BCG vaccinated guinea pigs mount robust CD1b-restricted, PIM-specific T cell responses

Jan Schinköthe , Annemieke Geluk , Tom H. M. Ottenhoff , Dennis Christensen , Martine Gilleron et al.
Molecular Approaches to Vaccines and Immune Monitoring, Feb 2019, keystone, United States
Poster de conférence hal-05024667 v1

BCG vaccination induces robust PIM-specific, CD1b restricted CD4-positive T cell responses in Guinea pigs

Jan Schinköthe , Annemieke Geluk , Tom H. M. Ottenhoff , Dennis Christensen , Martine Gilleron et al.
EMBO Workshop - CD1-MR1 : Beyond MHC-restricted lymphocytes, Oxford, Sep 2019, Oxford (UK), United Kingdom
Poster de conférence hal-05024649 v1

Functional Heterogeneity of Human T Cells that Recognize Mycobacterial Sulfoglycolipids

Charlotte James , Krystle K.Q. Yu , Martine Gilleron , Adriaan Minnaard , Chetan Seshadri
Molecular Approaches to Vaccines and Immune Monitoring, Feb 2019, keystone, United States
Poster de conférence hal-05024684 v1
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Asymmetric Total Synthesis and Structural Revision of DAT2, an Antigenic Glycolipid from Mycobacterium tuberculosis

Zonghao Lin , Jeya Prathap Kaniraj , Mira Holzheimer , Jérôme Nigou , Martine Gilleron et al.
Angewandte Chemie International Edition, 2024, 63 (19), pp.e202318582. ⟨10.1002/anie.202318582⟩
Article dans une revue hal-04711264 v1
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Impact of methylthioxylose substituents on the biological activities of lipomannan and lipoarabinomannan in Mycobacterium tuberculosis

Zuzana Palčeková , Kavita De , Shiva Kumar Angala , Martine Gilleron , Sophie Zuberogoïtia et al.
ACS Infectious Diseases, 2024, 10 (4), pp.1379-1390. ⟨10.1021/acsinfecdis.4c00079⟩
Article dans une revue hal-04725853 v1
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Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge

Emmelie Eckhardt , Jan Schinköthe , Marcel Gischke , Julia Sehl-Ewert , Björn Corleis et al.
Scientific Reports, 2023, 13 (1), pp.18613. ⟨10.1038/s41598-023-45898-3⟩
Article dans une revue hal-04412358 v1
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Role of succinyl substituents in the mannose-capping of lipoarabinomannan and control of inflammation in Mycobacterium tuberculosis infection

Zuzana Palčeková , Andrés Obregón-Henao , Kavita De , Amanda Walz , Ha Lam et al.
PLoS Pathogens, 2023, 19 (9), pp.e1011636. ⟨10.1371/journal.ppat.1011636⟩
Article dans une revue hal-04238654 v1
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Supramolecular organization and dynamics of mannosylated phosphatidylinositol lipids in the mycobacterial plasma membrane

Chelsea Brown , Robin Corey , Axelle Grélard , Ya Gao , Yeol Kyo Choi et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (5), pp.e2212755120. ⟨10.1073/pnas.2212755120⟩
Article dans une revue hal-04037054 v1
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A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

Sergio Fabián Mosquera-Restrepo , Sophie Zuberogoïtia , Lucie Gouxette , Emilie Layre , Martine Gilleron et al.
Nature Communications, 2022, 13 (1), pp.7751. ⟨10.1038/s41467-022-35453-5⟩
Article dans une revue hal-04260471 v1
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CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Charlotte James , Yuexin Xu , Melissa Aguilar , Lichen Jing , Erik Layton et al.
Nature Communications, 2022, 13 (1), pp.78. ⟨10.1038/s41467-021-27764-w⟩
Article dans une revue hal-03818954 v2
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Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA

Itxaso Anso , Luis G. M. Basso , Lei Wang , Alberto Marina , Edgar Páez-Pérez et al.
Science Advances , 2021, 7 (42), pp.1-17. ⟨10.1126/sciadv.abj4565⟩
Article dans une revue hal-03818988 v1
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Polysaccharide Succinylation Enhances the Intracellular Survival of Mycobacterium abscessus

Zuzana Palčeková , Martine Gilleron , Shiva Kumar Angala , Juan Manuel Belardinelli , Michael Mcneil et al.
ACS Infectious Diseases, 2020, 6 (8), pp.2235-2248. ⟨10.1021/acsinfecdis.0c00361⟩
Article dans une revue hal-03008493 v1
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A Direct Role for the CD1b Endogenous Spacer in the Recognition of a Mycobacterium tuberculosis Antigen by T-Cell Receptors

Frank Camacho , Ernesto Moreno , Luis Garcia-Alles , Glay Chinea Santiago , Martine Gilleron et al.
Frontiers in Immunology, 2020, 11, pp.566710. ⟨10.3389/fimmu.2020.566710⟩
Article dans une revue hal-02992100 v1
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Disruption of the SucT acyltransferase in Mycobacterium smegmatis abrogates succinylation of cell envelope polysaccharides

Zuzana Palčeková , Shiva Angala , Juan Manuel Belardinelli , Haig Eskandarian , Maju Joe et al.
Journal of Biological Chemistry, 2019, 294 (26), pp.10325-10335. ⟨10.1074/jbc.RA119.008585⟩
Article dans une revue hal-02325319 v1

Interactions of domain antibody (dAbκ11) with Mycobacterium tuberculosis Ac2SGL in complex with CD1b

Cheh Tat Law , Frank Camacho , Luis Garcia-Alles , Martine Gilleron , Maria Sarmiento et al.
Tuberculosis, 2019, 114, pp.9-16. ⟨10.1016/j.tube.2018.11.002⟩
Article dans une revue hal-03367109 v1

Mycobacteria exploit nitric oxide‐induced transformation of macrophages into permissive giant cells

Kourosh Gharun , Julia Senges , Maximilian Seidl , Anne Lösslein , Julia Kolter et al.
EMBO Reports, 2018, 19 (12), ⟨10.15252/embr.201847190⟩
Article dans une revue hal-02325356 v1
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CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

Charlotte R James , Krystle K.Q. Yu , Martine Gilleron , Jacques Prandi , Vijayendar Yedulla et al.
Cell Chemical Biology, 2018, 25 (4), pp.392-402.e14. ⟨10.1016/j.chembiol.2018.01.006⟩
Article dans une revue hal-02325438 v1
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Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2

Alexiane Decout , Sandro Silva-Gomes , Daniel Drocourt , Emilyne Blattes , Michel Rivière et al.
Scientific Reports, 2018, 8 (1), pp.16840. ⟨10.1038/s41598-018-35393-5⟩
Article dans une revue hal-01957981 v1
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Rational design of adjuvants targeting the C-type lectin Mincle

Alexiane Decout , Sandro Silva-Gomes , Daniel Drocourt , Sophie Barbe , Isabelle André et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (10), pp.2675-2680. ⟨10.1073/pnas.1612421114⟩
Article dans une revue hal-01607936 v1

The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria

Montse Tersa , Lluís Raich , David Albesa-Jové , Beatriz Trastoy , Jacques Prandi et al.
ACS Chemical Biology, 2017, 13 (1), pp.131-140. ⟨10.1021/acschembio.7b00578⟩
Article dans une revue hal-03178131 v1
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Biosynthesis of the Methylthioxylose Capping Motif of Lipoarabinomannan in Mycobacterium tuberculosis

Shiva Kumar Angala , Michael Mcneil , Libin Shi , Maju Joe , Ha Pham et al.
ACS Chemical Biology, 2017, 12 (3), pp.682-691. ⟨10.1021/acschembio.6b01071⟩
Article dans une revue hal-03178068 v1

Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis

Gerald Larrouy-Maumus , Emilie Layre , Simon Clark , Jacques Prandi , Emma Rayner et al.
Vaccine, 2017, 35 (10), pp.1395-1402. ⟨10.1016/j.vaccine.2017.01.079⟩
Article dans une revue hal-02407908 v1

Mycobacteria exploit nitric oxide‐induced transformation of macrophages into permissive giant cells

Kourosh Gharun , Julia Senges , Maximilian Seidl , Anne Lösslein , Julia Kolter et al.
EMBO Reports, 2017, 18 (12), pp.2144-2159. ⟨10.15252/embr.201744121⟩
Article dans une revue hal-03178128 v1

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids

Landry Blanc , Martine Gilleron , Jacques Prandi , Ok-Ryul Song , Mi-Seon Jang et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (42), pp.11205-11210. ⟨10.1073/pnas.1707840114⟩
Article dans une revue hal-03178071 v1

Selection of phage-displayed human antibody fragments specific for CD1b presenting the Mycobacterium tuberculosis glycolipid Ac2SGL

Frank Camacho , Maria Sarmiento , Fátima Reyes , Louise Kim , Jim Huggett et al.
International Journal of Mycobacteriology, 2016, 5 (2), pp.120-127. ⟨10.1016/j.ijmyco.2015.12.002⟩
Article dans une revue hal-03178062 v1

BCG Vaccination Induces Robust CD4 + T Cell Responses to Mycobacterium tuberculosis Complex–Specific Lipopeptides in Guinea Pigs

Eva Kaufmann , Christina Spohr , Sibylle Battenfeld , Diane de Paepe , Thomas Holzhauser et al.
Journal of Immunology, 2016, 196 (6), pp.2723-2732. ⟨10.4049/jimmunol.1502307⟩
Article dans une revue hal-03178061 v1

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization

Philippe Barthe , Romain Veyron-Churlet , Angélique De visch , Martine Gilleron , Jean-Michel Saliou et al.
Structure, 2016, 24 (10), pp.1788-1794. ⟨10.1016/j.str.2016.07.009⟩
Article dans une revue hal-03178065 v1

Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens

Martine Gilleron , Marco Lepore , Emilie Layre , Diane Cala-De paepe , Naila Mebarek et al.
Cell Chemical Biology, 2016, 23 (9), pp.1147-1156. ⟨10.1016/j.chembiol.2016.07.021⟩
Article dans une revue hal-03096294 v1
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A glycomic approach reveals a new mycobacterial polysaccharide

Gerald Larrouy-Maumus , Martine Gilleron , Henrieta Skovierová , Sophie Zuberogoitia , Patrick Brennan et al.
Glycobiology, 2015, 25 (11), pp.1163-1171. ⟨10.1093/glycob/cwv061⟩
Article dans une revue hal-03178008 v1

Ac2PIM-responsive miR-150 and miR-143 Target Receptor-interacting Protein Kinase 2 and Transforming Growth Factor Beta-activated Kinase 1 to Suppress NOD2-induced Immunomodulators

Praveen Prakhar , Sahana Holla , Devram Sampat Ghorpade , Martine Gilleron , Germain Puzo et al.
Journal of Biological Chemistry, 2015, 290 (44), pp.26576-26586. ⟨10.1074/jbc.M115.662817⟩
Article dans une revue hal-03178049 v1
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T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents

Chetan Seshadri , Lin Lin , Thomas J Scriba , Glenna Peterson , David Freidrich et al.
Journal of Immunology, 2015, 195 (10), pp.4595-4603. ⟨10.4049/jimmunol.1501285⟩
Article dans une revue hal-03178052 v1

Simplified Deoxypropionate Acyl Chains for Mycobacterium tuberculosis Sulfoglycolipid Analogues: Chain Length is Essential for High Antigenicity

Benjamin Gau , Aurélie Lemétais , Marco Lepore , Luis Fernando Garcia-Alles , Yann Bourdreux et al.
ChemBioChem, 2013, 14 (18), pp.2413-2417. ⟨10.1002/cbic.201300482⟩
Article dans une revue istex hal-03178038 v1
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Tuberculosis 2012: biology, pathogenesis and intervention strategies; an update from the city of light [meeting report]

Alexandre Gouzy , Jérôme Nigou , Martine Gilleron , Olivier Neyrolles , Ludovic Tailleux et al.
Research in Microbiology, 2013, 164 (3), pp.270-280. ⟨10.1016/j.resmic.2012.12.006⟩
Article dans une revue pasteur-03525497 v1
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Deciphering the Role of CD1e Protein in Mycobacterial Phosphatidyl- myo -inositol Mannosides (PIM) Processing for Presentation by CD1b to T Lymphocytes

Diane Cala-de Paepe , Emilie Layre , Gaëlle Giacometti , Luis Garcia-Alles , Lucia Mori et al.
Journal of Biological Chemistry, 2012, 287 (37), pp.31494-31502. ⟨10.1074/jbc.M112.386300⟩
Article dans une revue hal-03096337 v1
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A Small Multidrug Resistance-like Transporter Involved in the Arabinosylation of Arabinogalactan and Lipoarabinomannan in Mycobacteria*

Gerald Larrouy-Maumus , Henrieta Škovierová , Rabeb Dhouib , Shiva Kumar Angala , Sophie Zuberogoitia et al.
Journal of Biological Chemistry, 2012, 287 (47), pp.39933-39941. ⟨10.1074/jbc.M112.400986⟩
Article dans une revue hal-03178003 v1
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Lipoglycans Contribute to Innate Immune Detection of Mycobacteria

Shyam Krishna , Aurélie Ray , Shiv Dubey , Gerald Larrouy-Maumus , Christian Chalut et al.
PLoS ONE, 2011, 6 (12), pp.e28476. ⟨10.1371/journal.pone.0028476⟩
Article dans une revue hal-02391864 v1
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Deciphering sulfoglycolipids of Mycobacterium tuberculosis

Emilie Layre , Diane Cala-de Paepe , Gerald Larrouy-Maumus , Julien Vaubourgeix , Sathish Mundayoor et al.
Journal of Lipid Research, 2011, 52 (6), pp.1098-1110. ⟨10.1194/jlr.M013482⟩
Article dans une revue hal-03096390 v1

Membrane-associated DegP in Bordetella chaperones a repeat-rich secretory protein

Catherine Baud , Irina Gutsche , Eve Willery , Diane de Paepe , Hervé Drobecq et al.
Molecular Microbiology, 2011, 80 (6), pp.1625-1636. ⟨10.1111/j.1365-2958.2011.07672.x⟩
Article dans une revue hal-03177988 v1

Lipoteichoic Acid in Streptomyces hygroscopicus: Structural Model and Immunomodulatory Activities

Marlène Cot , Aurélie Ray , Martine Gilleron , Alain Vercellone , Gerald Larrouy-Maumus et al.
PLoS ONE, 2011, 6 (10), pp.e26316. ⟨10.1371/journal.pone.0026316⟩
Article dans une revue hal-03177994 v1
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Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes

Luis Garcia-Alles , Gaelle Giacometti , Cees Versluis , Laurent Maveyraud , Diane de Paepe et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (32), pp.13230 - 13235. ⟨10.1073/pnas.1105627108⟩
Article dans une revue hal-03003375 v1

Fine tuning by human CD1e of lipid-specific immune responses

Federica Facciotti , Marco Cavallari , Catherine Angenieux , Luis Garcia-Alles , François Signorino-Gelo et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (34), pp.14228-14233. ⟨10.1073/pnas.1108809108⟩
Article dans une revue hal-03367125 v1
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Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids

L F Garcia-Alles , A Collmann , C Versluis , B Lindner , J Guiard et al.
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (43), pp.17755 - 17760. ⟨10.1073/pnas.1110118108⟩
Article dans une revue hal-03003377 v1
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High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling

Priscille Brodin , Yannick Poquet , Florence Levillain , Isabelle Peguillet , Gerald Larrouy-Maumus et al.
PLoS Pathogens, 2010, 6 (9), pp.e1001100. ⟨10.1371/journal.ppat.1001100⟩
Article dans une revue hal-02902031 v1

Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan

Nicole Driessen , Esther Stoop , Roy Ummels , Sudagur Gurcha , Arun Mishra et al.
Microbiology, 2010, 156 (11), pp.3492-3502. ⟨10.1099/mic.0.037507-0⟩
Article dans une revue hal-03177979 v1

Biosynthetic Origin of the Galactosamine Substituent of Arabinogalactan in Mycobacterium tuberculosis*

Henrieta Škovierová , Gerald Larrouy-Maumus , Ha Pham , Martina Belanová , Nathalie Barilone et al.
Journal of Biological Chemistry, 2010, 285 (53), pp.41348-41355. ⟨10.1074/jbc.M110.188110⟩
Article dans une revue hal-03177982 v1

Fatty Acyl Structures of Mycobacterium tuberculosis Sulfoglycolipid Govern T Cell Response

Julie Guiard , Anthony Collmann , Luis Garcia-Alles , Lionel Mourey , Thérèse Brando et al.
Journal of Immunology, 2009, 182 (11), pp.7030 - 7037. ⟨10.4049/jimmunol.0804044⟩
Article dans une revue hal-03003394 v1

AftD, a novel essential arabinofuranosyltransferase from mycobacteria

Henrieta Škovierová , Gerald Larrouy-Maumus , Jian Zhang , Devinder Kaur , Nathalie Barilone et al.
Glycobiology, 2009, 19 (11), pp.1235-1247. ⟨10.1093/glycob/cwp116⟩
Article dans une revue hal-03177973 v1

Mycolic Acids Constitute a Scaffold for Mycobacterial Lipid Antigens Stimulating CD1-Restricted T Cells

Emilie Layre , Anthony Collmann , Max Bastian , Sabrina Mariotti , Jerzy Czaplicki et al.
Chemistry & biology, 2009, 16 (1), pp.82-92. ⟨10.1016/j.chembiol.2008.11.008⟩
Article dans une revue hal-03177940 v1
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The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments

Blandine Maître , Catherine Angénieux , Virginie Wurtz , Emilie Layre , Martine Gilleron et al.
Biochemical Journal, 2009, 419 (3), pp.661-668. ⟨10.1042/BJ20082204⟩
Article dans une revue hal-00479127 v1

SOCS3 expression induced by PIM2 requires PKC and PI3K signaling

Yeddula Narayana , Kushagra Bansal , Akhauri Yash Sinha , Nisha Kapoor , Germain Puzo et al.
Molecular Immunology, 2009, 46 (15), pp.2947-2954. ⟨10.1016/j.molimm.2009.06.019⟩
Article dans une revue istex hal-03177968 v1
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Mycobacterial phosphatidyl inositol mannosides negatively regulate host toll-like receptor 4, MYD88-dependent proinflammatory cytokines and trif-dependent co-stimulatory molecules expression.

Emilie Doz , Stéphanie Rose , Nathalie Court , Sophie Front , Virginie Vasseur et al.
Journal of Biological Chemistry, 2009, 284, epub ahead of print. ⟨10.1074/jbc.M109.037846⟩
Article dans une revue hal-00404964 v1

PIM2 Induced COX-2 and MMP-9 Expression in Macrophages Requires PI3K and Notch1 Signaling

Kushagra Bansal , Nisha Kapoor , Yeddula Narayana , Germain Puzo , Martine Gilleron et al.
PLoS ONE, 2009, 4 (3), pp.e4911. ⟨10.1371/journal.pone.0004911⟩
Article dans une revue hal-03177965 v1

Cutting edge: a naturally occurring mutation in CD1e impairs lipid antigen presentation.

Sylvie Tourne , Blandine Maitre , Anthony Collmann , Emilie Layre , Sabrina Mariotti et al.
Journal of Immunology, 2008, 180 (6), pp.3642-6
Article dans une revue inserm-00351035 v1

Mannan Chain Length Controls Lipoglycans Signaling via and Binding to TLR2

Jérôme Nigou , Thierry Vasselon , Aurélie Ray , Patricia Constant , Martine Gilleron et al.
Journal of Immunology, 2008, 180 (10), pp.6696-6702. ⟨10.4049/jimmunol.180.10.6696⟩
Article dans une revue hal-03177926 v1

Synthesis of Diacylated Trehalose Sulfates: Candidates for a Tuberculosis Vaccine

Julie Guiard , Anthony Collmann , Martine Gilleron , Lucia Mori , Gennaro De libero et al.
Angewandte Chemie International Edition, 2008, 47 (50), pp.9734-9738. ⟨10.1002/anie.200803835⟩
Article dans une revue hal-03177927 v1

Identification of an ?(1?6) mannopyranosyltransferase (MptA), involved in Corynebacterium glutamicum lipomanann biosynthesis, and identification of its orthologue in Mycobacterium tuberculosis

Arun Mishra , Luke Alderwick , Doris Rittmann , Raju Tatituri , Jérôme Nigou et al.
Molecular Microbiology, 2007, 65 (6), pp.1503-1517. ⟨10.1111/j.1365-2958.2007.05884.x⟩
Article dans une revue hal-03177909 v1

Mycobacterial Lipomannan Induces Granuloma Macrophage Fusion via a TLR2-Dependent, ADAM9- and β 1 Integrin-Mediated Pathway

Marie-Pierre Puisségur , Guillaume Lay , Martine Gilleron , Laure Botella , Jérôme Nigou et al.
Journal of Immunology, 2007, 178 (5), pp.3161-3169. ⟨10.4049/jimmunol.178.5.3161⟩
Article dans une revue hal-03177922 v1

Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannan.

Emilie Doz , Stéphanie Rose , Jérôme Nigou , Martine Gilleron , Germain Puzo et al.
Journal of Biological Chemistry, 2007, 282 (36), pp.26014-25. ⟨10.1074/jbc.M702690200⟩
Article dans une revue hal-00318491 v1

Acylation Determines the Toll-like receptor (TLR)-dependent Positive Versus TLR2-, Mannose Receptor-, and SIGNR1-independent Negative Regulation of Pro-inflammatory Cytokines by Mycobacterial Lipomannan

Emilie Doz , Stéphanie Rose , Jérôme Nigou , Martine Gilleron , Germain Puzo et al.
Journal of Biological Chemistry, 2007, 282 (36), pp.26014-26025. ⟨10.1074/jbc.M702690200⟩
Article dans une revue hal-03177915 v1

Structural characterization of a partially arabinosylated lipoarabinomannan variant isolated from a Corynebacterium glutamicum ubiA mutant

Raju Venkata Veera Tatituri , Luke Alderwick , Arun Mishra , Jérôme Nigou , Martine Gilleron et al.
Microbiology, 2007, 153 (8), pp.2621-2629. ⟨10.1099/mic.0.2007/008078-0⟩
Article dans une revue hal-03177903 v1

The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2.

Martine Gilleron , Jérôme Nigou , Delphine Nicolle , Valérie Quesniaux , Germain Puzo
Chemistry & Biology / Chemistry and Biology; CHEMISTRY & BIOLOGY, 2006, 13 (1), pp.39-47. ⟨10.1016/j.chembiol.2005.10.013⟩
Article dans une revue hal-00177665 v1

MS/MS approach for characterization of the fatty acid distribution on mycobacterial phosphatidyl-myo-inositol mannosides.

Martine Gilleron , Buko Lindner , Germain Puzo
Analytical Chemistry, 2006, 78 (24), pp.8543-8. ⟨10.1021/ac061574a⟩
Article dans une revue istex hal-00177661 v1

Characterization of a truncated lipoarabinomannan from the Actinomycete Turicella otitidis.

Martine Gilleron , Natalie J Garton , Jérôme Nigou , Thérèse Brando , Germain Puzo et al.
Journal of Bacteriology, 2005, 187 (3), pp.854-61. ⟨10.1128/JB.187.3.854-861.2005⟩
Article dans une revue hal-00177631 v1
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A lipomannan with strong TLR-2 dependant pro-inflammatory activity in Saccharothrix aerocolonigenes

Kevin J. C. Gibson , M. Gilleron , P. Constant , B. Sichi , G. Puzo et al.
Journal of Biological Chemistry, 2005, 280 (31), pp.28347-28356. ⟨10.1074/jbc.M505498200⟩
Article dans une revue hal-00077260 v1

Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process

Christina Villeneuve-Faure , M. Gilleron , I. Maridonneau-Parini , M. Daffé , Catherine Astarie-Dequeker et al.
Journal of Lipid Research, 2005, 46, pp.475-483
Article dans une revue hal-00078727 v1

Assistance of Microbial Glycolipid Antigen Processing by CD1e

Henri de La Salle , Sabrina Mariotti , Catherine Angénieux , Martine Gilleron , Luis Fernando Garcia-Alles et al.
Science, 2005, 310 (5752), pp.1321-1324. ⟨10.1126/science.1115301⟩
Article dans une revue hal-03003514 v1

CD1e participates in processing of microbial glycolipid antigens

De La Salle H. , S. Mariotti , C. Angenieux , M. Gilleron , Garcia-Alles L.-F. et al.
Science, 2005, 310 (5752), pp.1321-1324
Article dans une revue hal-00077256 v1

Structural analysis of mycobacterial lipoglycans.

Jérôme Nigou , Martine Gilleron , Thérèse Brando , Germain Puzo
Applied Biochemistry and Biotechnology, 2004, 118 (1-3), pp.253-67
Article dans une revue hal-00177964 v1

Diacylated sulfoglycolipids are novel mycobacterial antigens stimulating CD1-restricted T cells during infection with Mycobacterium tuberculosis.

Martine Gilleron , Steffen Stenger , Zaima Mazorra , Frederick Wittke , Sabrina Mariotti et al.
Journal of Experimental Medicine, 2004, 199 (5), pp.649-59. ⟨10.1084/jem.20031097⟩
Article dans une revue hal-00177628 v1

Tsukamurella paurometabola Lipoglycan, a New Lipoarabinomannan Variant with Pro-inflammatory Activity

Kevin J.C. Gibson , Martine Gilleron , Patricia Constant , Thérèse Brando , Germain Puzo et al.
Journal of Biological Chemistry, 2004, 279 (22), pp.22973-22982. ⟨10.1074/jbc.M310906200⟩
Article dans une revue hal-03177877 v1

Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphurea

Kevin Gibson , Martine Gilleron , Patricia Constant , Germain Puzo , Jérôme Nigou et al.
Biochemical Journal, 2003, 372 (3), pp.821-829. ⟨10.1042/BJ20030197⟩
Article dans une revue hal-03177850 v1

Acylation state of the phosphatidyl inositol hexamannosides from Mycobacterium bovis BCG and its implication in TLR response

M. Gilleron , Valérie Quesniaux , G. Puzo
Journal of Biological Chemistry, 2003, 278, pp.29880-9
Article dans une revue hal-00095088 v1
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Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response.

Martine Gilleron , Valérie Quesniaux , Germain Puzo
Journal of Biological Chemistry, 2003, 278 (32), pp.29880-29889. ⟨10.1074/jbc.M303446200⟩
Article dans une revue hal-00177668 v1

Structural and functional features of Rhodococcus ruber lipoarabinomannan

Kevin Gibson , Martine Gilleron , Patricia Constant , Germain Puzo , Jérôme Nigou et al.
Microbiology, 2003, 149 (6), pp.1437-1445. ⟨10.1099/mic.0.26161-0⟩
Article dans une revue hal-03177852 v1

Identification of the Required Acyltransferase Step in the Biosynthesis of the Phosphatidylinositol Mannosides of Mycobacterium Species

Jana Korduláková , Martine Gilleron , Germain Puzo , Patrick Brennan , Brigitte Gicquel et al.
Journal of Biological Chemistry, 2003, 278 (38), pp.36285-36295. ⟨10.1074/jbc.M303639200⟩
Article dans une revue hal-03177874 v1

Lipoarabinomannans: from structure to biosynthesis.

Jérôme Nigou , Martine Gilleron , Germain Puzo
Biochimie, 2003, 85 (1-2), pp.153-66
Article dans une revue hal-00177973 v1

Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response.

Jérôme Nigou , Martine Gilleron , Mauricio Rojas , Luis F García , Martin Thurnher et al.
Microbes and Infection, 2002, 4 (9), pp.945-53
Article dans une revue hal-00177974 v1

Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells.

Martin Mempel , Catherine Ronet , Felipe Suarez , Martine Gilleron , Germain Puzo et al.
Journal of Immunology, 2002, 168 (1), pp.365-71. ⟨10.4049/jimmunol.168.1.365⟩
Article dans une revue hal-00177983 v1

A Novel Lipoarabinomannan from the Equine PathogenRhodococcus equi

Natalie Garton , Martine Gilleron , Thérèse Brando , Han-Hong Dan , Steeve Giguère et al.
Journal of Biological Chemistry, 2002, 277 (35), pp.31722-31733. ⟨10.1074/jbc.M203008200⟩
Article dans une revue hal-03177770 v1

Definition of the First Mannosylation Step in Phosphatidylinositol Mannoside Synthesis

Jana Korduláková , Martine Gilleron , Katarína Mikus̃ová , Germain Puzo , Patrick Brennan et al.
Journal of Biological Chemistry, 2002, 277 (35), pp.31335-31344. ⟨10.1074/jbc.M204060200⟩
Article dans une revue hal-03177773 v1

Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure.

Pascal Ludwiczak , Martine Gilleron , Yann Bordat , Carlos Martin , Brigitte Gicquel et al.
Microbiology, 2002, 148 (Pt 10), pp.3029-37. ⟨10.1099/00221287-148-10-3029⟩
Article dans une revue hal-00177982 v1

Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor.

J. Nigou , C. Zelle-Rieser , M. Gilleron , M. Thurnher , G. Puzo
Journal of Immunology, 2001, 166 (12), pp.7477-85
Article dans une revue hal-00177977 v1
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Acylation state of the phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette Guérin and ability to induce granuloma and recruit natural killer T cells.

M. Gilleron , C. Ronet , M. Mempel , B. Monsarrat , Gabriel Gachelin et al.
Journal of Biological Chemistry, 2001, 276 (37), pp.34896-904. ⟨10.1074/jbc.M103908200⟩
Article dans une revue hal-00177669 v1
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Mycobacterium tuberculosis H37Rv parietal and cellular lipoarabinomannans. Characterization of the acyl- and glyco-forms.

M. Gilleron , L. Bala , T. Brando , Alain Vercellone , G. Puzo
Journal of Biological Chemistry, 2000, 275 (1), pp.677-84
Article dans une revue hal-00177657 v1

A New Combined Computational and NMR-Spectroscopical Strategy for the Identification of Additional Conformational Constraints of the Bound Ligand in an Aprotic Solvent

Hans-Christian Siebert , Sabine André , Juan Luis Asensio , Francisco Javier Cañada , Xin Dong et al.
Article dans une revue hal-03177758 v1

Structural definition of arabinomannans from Mycobacterium bovis BCG.

J. Nigou , M. Gilleron , T. Brando , A. Vercellone , G. Puzo
Glycoconjugate Journal, 1999, 16 (6), pp.257-64
Article dans une revue hal-00177967 v1

Lipoarabinomannans: characterization of the multiacylated forms of the phosphatidyl-myo-inositol anchor by NMR spectroscopy.

J. Nigou , M. Gilleron , G. Puzo
Biochemical Journal, 1999, 337 ( Pt 3), pp.453-60
Article dans une revue hal-00177972 v1

Structural study of the lipomannans from Mycobacterium bovis BCG: characterisation of multiacylated forms of the phosphatidyl-myo-inositol anchor.

M. Gilleron , J. Nigou , B. Cahuzac , G. Puzo
Journal of Molecular Biology, 1999, 285 (5), pp.2147-60. ⟨10.1006/jmbi.1998.2438⟩
Article dans une revue istex hal-00177663 v1

Conformer selection and differential restriction of ligand mobility by a plant lectin--conformational behaviour of Galbeta1-3GlcNAcbeta1-R, Galbeta1-3GalNAcbeta1-R and Galbeta1-2Galbeta1-R' in the free state and complexed with galactoside-specific mistletoe lectin as revealed by random-walk and conformational-clustering molecular-mechanics.

M. Gilleron , H. C. Siebert , H. Kaltner , C. W. von Der Lieth , T. Kozár et al.
European Journal of Biochemistry, 1998, 252 (3), pp.416-27
Article dans une revue hal-00177954 v1

Lectin Ligands: New Insights into Their Conformations and Their Dynamic Behavior and the Discovery of Conformer Selection by Lectins

C.-W. von Der Lieth , H.-C. Siebert , T. Kožár , M. Burchert , M. Frank et al.
Cells Tissues Organs, 1998, 161 (1-4), pp.91-109. ⟨10.1159/000046452⟩
Article dans une revue hal-03177755 v1

Comparative structural study of the mannosylated-lipoarabinomannans from Mycobacterium bovis BCG vaccine strains: characterization and localization of succinates.

C. Delmas , M. Gilleron , T. Brando , A. Vercellone , M. Gheorghui et al.
Glycobiology, 1997, 7 (6), pp.811-7
Article dans une revue hal-00177980 v1
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Mycobacterium smegmatis phosphoinositols-glyceroarabinomannans. Structure and localization of alkali-labile and alkali-stable phosphoinositides.

M. Gilleron , N. Himoudi , O. Adam , P. Constant , A. Venisse et al.
Journal of Biological Chemistry, 1997, 272 (1), pp.117-24. ⟨10.1074/jbc.m109.037846⟩
Article dans une revue hal-00177659 v1
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The phosphatidyl-myo-inositol anchor of the lipoarabinomannans from Mycobacterium bovis bacillus Calmette Guérin. Heterogeneity, structure, and role in the regulation of cytokine secretion.

J. Nigou , M. Gilleron , B. Cahuzac , J. D. Bounéry , M. Herold et al.
Journal of Biological Chemistry, 1997, 272 (37), pp.23094-23103
Article dans une revue hal-00177970 v1

A novel nucleotide-containing antigen for human blood γδ T lymphocytes

Yannick Poquet , Patricia Constant , Franck Halary , Marie-Alix Peyrat , Martine Gilleron et al.
European Journal of Immunology, 1996, 26 (10), pp.2344-2349. ⟨10.1002/eji.1830261011⟩
Article dans une revue hal-03012109 v1

NMR-Based, Molecular Dynamics- and Random Walk Molecular Mechanics-Supported Study of Conformational Aspects of a Carbohydrate Ligand (Galβ1-2Galβ1-R) for an Animal Galectin in the Free and in the Bound State

Hans-Christian Siebert , Martine Gilleron , Herbert Kaltner , Claus-Wilhelm von Der Lieth , Tibor Kozár et al.
Biochemical and Biophysical Research Communications, 1996, 219 (1), pp.205-212. ⟨10.1006/bbrc.1996.0206⟩
Article dans une revue hal-03177749 v1

Lipooligosacc haridic antigens fromMycobacterium kansasii andMycobacterium gastri

Martine Gilleron , Germain Puzo
Glycoconjugate Journal, 1995, 12 (3), pp.298-308. ⟨10.1007/BF00731333⟩
Article dans une revue istex hal-03177744 v1

Lipooligosaccharidic antigens from Mycobacterium kansasii and Mycobacterium gastri.

M. Gilleron , G. Puzo
Glycoconjugate Journal, 1995, 12 (3), pp.298-308
Article dans une revue hal-00177667 v1

Lipo-oligosaccharidic antigen from Mycobacterium gastri. Complete structure of a novel C4-branched 3,6-dideoxy-alpha-xylo-hexopyranose.

M. Gilleron , J. Vercauteren , G. Puzo
Biochemistry, 1994, 33 (7), pp.1930-7
Article dans une revue hal-00177962 v1

Lipo-oligosaccharidic antigen from Mycobacterium gastri. Complete structure of a novel C4-branched 3,6-dideoxy-.alpha.-xylo-hexopyranose

Martine Gilleron , Joseph Vercauteren , Germain Puzo
Biochemistry, 1994, 33 (7), pp.1930-1937. ⟨10.1021/bi00173a041⟩
Article dans une revue istex hal-03177418 v1

Lipooligosaccharidic antigen containing a novel C4-branched 3,6-dideoxy-alpha-hexopyranose typifies Mycobacterium gastri.

M. Gilleron , J. Vercauteren , G. Puzo
Journal of Biological Chemistry, 1993, 268 (5), pp.3168-79
Article dans une revue hal-00177961 v1
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Lipooligosaccharidic Antigen Containing a Novel C4-branched 3,6-Dideoxy-a-hexopyranose Typifies Mycobacterium gastri

Martine Gilleron , Joseph Vercauterent , Germain Puzosv
Journal of Biological Chemistry, 1993, 268 (5), pp.3168-3179. ⟨10.1016/S0021-9258(18)53674-7⟩
Article dans une revue hal-03177435 v1
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Structural features of lipoarabinomannan from Mycobacterium bovis BCG. Determination of molecular mass by laser desorption mass spectrometry

Anne Venisse , Jean-Marc Berjeaud , Pierre Chaurand , Martine Gilleron , Germain Puzo
Journal of Biological Chemistry, 1993, 268 (17), pp.12401-12411. ⟨10.1016/S0021-9258(18)31404-2⟩
Article dans une revue hal-03177445 v1

Structural and immunological properties of the phenolic glycolipids from Mycobacterium gastri and Mycobacterium kansasii.

M. Gilleron , A. Venisse , J. J. Fournie , M. Riviere , M. A. Dupont et al.
European Journal of Biochemistry, 1990, 189 (1), pp.167-73
Article dans une revue hal-00177956 v1

Carbohydrate epitope structural elucidation by 1H-NMR spectroscopy of a new Mycobacterium kansasii phenolic glycolipid antigen

Martine Gilleron , Anne Venisse , Michel Rivière , Philippe Servin , Germain Puzo
European Journal of Biochemistry, 1990, 193 (2), pp.449-457. ⟨10.1111/j.1432-1033.1990.tb19359.x⟩
Article dans une revue hal-03012112 v1

Structural and immunological properties of the phenolic glycolids from Mycobacterium gastri and Mycobacterium kansasii

Martine Gilleron , Anne Venisse , Jean-Jacques Fournié , Michel Rivière , Marie-Ange Dupont et al.
European Journal of Biochemistry, 1990, 189 (1), pp.167-173. ⟨10.1111/j.1432-1033.1990.tb15473.x⟩
Article dans une revue hal-03012115 v1

Transverse and lateral distribution of phospholipids and glycolipids in the membrane of the bacterium Micrococcus luteus

J. de Bony , A. Lopez , Martine Gilleron , M. Welby , G. Laneelle et al.
Biochemistry, 1989, 28 (9), pp.3728-3737. ⟨10.1021/bi00435a016⟩
Article dans une revue istex hal-03177414 v1