Mathieu GENDROT

32
Documents

Présentation

Education and degrees

Ph.D. 2, « Proveblue as an antimalarial drug » Supervisor : PHC Bruno PRADINES. Curent year 2018-2019, Institut de Recherche Biomédicale des Armées. IHU Méditerranée Infection Marseille, Parasitology-entomology unit.

Ph.D. 1, « Proveblue as an antimalarial drug » Supervisor : PHC Bruno PRADINES. Year 2017-2018, Institut de Recherche Biomédicale des Armées. IHU Méditerranée Infection Marseille, Parasitology-entomology unit.

Master degree 2, Human Pathology « Maladies infectieuses & contagion-prévention » Options : Medical entomology. Year 2016-2017, Marseille university. M

aster degree 1, Human Pathology « Du gène à la maladie » Options : Parasitology, bacteriology, virology, molecular biology. Year 2015-2016, Marseille university.

University degree 3, « Biochimie, biologie moléculaire cellulaire et physiologique » Options : Microbiology, Microbiology laboratory analysis, Virology. Year 2014-2015, Rouen university.

University degree 2, « Biochimie, biologie moléculaire cellulaire et physiologique » Options : Animal and plant parasitology, Biochemistry. Year 2013-2014, Rouen university.

University degree 1, « Science de la vie de la Terre et de l'environnement » Year 2012-2013, Rouen university. Bachelor degree, scientific option. Option: Life, Earth and Environment Sciences Year 2011-2012, High school Louis-Modeste Leroy, Evreux.

Professional experience

July 2017-now : Military volunteer (Officer cadet) of the French Service de Santé des Armées Ph.D. student, 2nd year under direction of supervisor PHC Bruno PRADINES

November 2018: One month trainee at Pasteur Institute of Cambodia in Phnom Penh Learning of Piperaquine survival assay and Ring survival assay, experiments on Cambodian resistant strains.

November 2017 : Initial Military Training Third Promotion at Gendarmerie of Rochefort, Promotion Major.

January to june 2017 : Six months trainee at malaria National Reference Center in Marseille « Use of Methylene blue Proveblue as an antimalarial drug in-vitro. »

May to june 2016 : Seven weeks trainee at malaria National Reference Center in Marseille « Identification and validation of molecular markers of resistance to antimalarial drugs. »

July to august 2015 : Six weeks trainee at malaria National Reference Center in Marseille « Identification and validation of molecular markers of resistance to antimalarial drugs. »

Publications

Publications

Image document

Methylene Blue-Based Combination Therapy with Amodiaquine Prevents Severe Malaria in an Experimental Rodent Model

Jérôme Dormoi , Rémy Amalvict , Mathieu Gendrot , Bruno Pradines
Pharmaceutics, 2022, 14 (10), pp.2031. ⟨10.3390/pharmaceutics14102031⟩
Article dans une revue hal-03949197 v1
Image document

Antiviral Activity of Repurposing Ivermectin against a Panel of 30 Clinical SARS-CoV-2 Strains Belonging to 14 Variants

Océane Delandre , Mathieu Gendrot , Priscilla Jardot , Marion Le Bideau , Manon Boxberger et al.
Pharmaceuticals, 2022, 15 (4), pp.445. ⟨10.3390/ph15040445⟩
Article dans une revue hal-03678577 v1
Image document

Comparative Assessment of the Sensitivity of Ten Commercial Rapid Diagnostic Test Kits for the Detection of Plasmodium

Mathieu Gendrot , Marylin Madamet , Isabelle Fonta , Nicolas Benoit , Rémy Amalvict et al.
Diagnostics, 2022, 12 (9), pp.2240. ⟨10.3390/diagnostics12092240⟩
Article dans une revue hal-03948586 v1
Image document

Absence of Association between Methylene Blue Reduced Susceptibility and Polymorphisms in 12 Genes Involved in Antimalarial Drug Resistance in African Plasmodium falciparum

Mathieu Gendrot , Océane Delandre , Marie Robert , Francis Foguim , Nicolas Benoit et al.
Pharmaceuticals, 2021, 14 (4), pp.351. ⟨10.3390/ph14040351⟩
Article dans une revue hal-03280743 v1

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

Caroline Souza Pereira , Helenita Costa Quadros , Diogo Rodrigo Magalhaes Moreira , William Castro , Romulo Ivisson Santos de Deus da Silva et al.
ChemMedChem, 2021, 16 (4), pp.662-678. ⟨10.1002/cmdc.202000653⟩
Article dans une revue hal-03160988 v1
Image document

In Vitro Evaluation of the Antiviral Activity of Methylene Blue Alone or in Combination against SARS-CoV-2

Mathieu Gendrot , Priscilla Jardot , Océane Delandre , Manon Boxberger , Julien Andreani et al.
Journal of Clinical Medicine, 2021, 10 (14), pp.3007. ⟨10.3390/jcm10143007⟩
Article dans une revue hal-03421132 v1
Image document

Plasmodium ovale wallikeri and P. ovale curtisi Infections and Diagnostic Approaches to Imported Malaria, France, 2013–2018

Valentin Joste , Justine Bailly , Véronique Hubert , Cécile Pauc , Mathieu Gendrot et al.
Emerging Infectious Diseases, 2021, 27 (2), ⟨10.3201/eid2702.202143⟩
Article dans une revue hal-03666032 v1

Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates

Celine Boschi , Marion Le Bideau , Julien Andreani , Sarah Aherfi , Priscilla Jardot et al.
Frontiers in Bioscience-Landmark, 2021, 26 (12), pp.1493-1502. ⟨10.52586/5043⟩
Article dans une revue hal-03663682 v1
Image document

Prevalence of Mutations in the pfcoronin Gene and Association with Ex Vivo Susceptibility to Common Quinoline Drugs against Plasmodium falciparum

Océane Delandre , Mathieu Gendrot , Isabelle Fonta , Joel Mosnier , Nicolas Benoit et al.
Pharmaceutics, 2021, 13 (8), pp.1273. ⟨10.3390/pharmaceutics13081273⟩
Article dans une revue hal-03429248 v1

Synthesis and antiplasmodial evaluation of 1H-1,2,3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues

Anu Saini , Sumit Kumar , Raghu Raj , Shefali Chowdhary , Mathieu Gendrot et al.
Bioorganic Chemistry, 2021, 109, pp.104733. ⟨10.1016/j.bioorg.2021.104733⟩
Article dans une revue hal-03280779 v1
Image document

Cytotoxic and Anti-Plasmodial Activities of Stephania dielsiana Y.C. Wu Extracts and the Isolated Compounds

James Knockleby , Bruno Pradines , Mathieu Gendrot , Joel Mosnier , Thanh Tam Nguyen et al.
Molecules, 2020, 25 (16), pp.3755. ⟨10.3390/molecules25163755⟩
Article dans une revue hal-02996315 v1
Image document

Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal

Océane Delandre , Sokhna Daffe , Mathieu Gendrot , Maguette Diallo , Marylin Madamet et al.
International Journal of Antimicrobial Agents, 2020, pp.106190. ⟨10.1016/j.ijantimicag.2020.106190⟩
Article dans une revue hal-02996284 v1
Image document

Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

Francis Tsombeng Foguim , Hervé Bogreau , Mathieu Gendrot , Joel Mosnier , Isabelle Fonta et al.
Malaria Journal, 2020, 19 (1), ⟨10.1186/s12936-020-03281-x⟩
Article dans une revue hal-02996272 v1

Implications des pompes membranaires de Plasmodium falciparum dans le transport et la résistance aux antipaludiques

Bruno Pradines , Mathieu Gendrot , Océane Delandre
Revue Francophone des Laboratoires, 2020, 2020 (519), pp.59-66. ⟨10.1016/S1773-035X(20)30063-0⟩
Article dans une revue hal-02996313 v1
Image document

Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate

Mathieu Gendrot , Isabelle Duflot , Manon Boxberger , Océane Delandre , Priscilla Jardot et al.
International Journal of Infectious Diseases, 2020, 99, pp.437-440. ⟨10.1016/j.ijid.2020.08.032⟩
Article dans une revue hal-02996298 v1

Baseline and multinormal distribution of ex vivo susceptibilities of Plasmodium falciparum to methylene blue in Africa, 2013–18

Mathieu Gendrot , Bruno Pradines , P Brouqui , Michel Drancourt , Marylin Madamet et al.
Journal of Antimicrobial Chemotherapy, 2020, 75 (8), pp.2141-2148. ⟨10.1093/jac/dkaa174⟩
Article dans une revue hal-02996303 v1

Amide Tethered 4-Aminoquinoline-naphthalimide Hybrids: A New Class of Possible Dual Function Antiplasmodials

Sumit Kumar , Mathieu Gendrot , Isabelle Fonta , Joel Mosnier , Nosipho Cele et al.
ACS Medicinal Chemistry Letters, 2020, 11 (12), pp.2544-2552. ⟨10.1021/acsmedchemlett.0c00536⟩
Article dans une revue hal-03165070 v1
Image document

Methylene blue inhibits replication of SARS-CoV-2 in vitro

Mathieu Gendrot , Julien Andreani , Isabelle Duflot , Manon Boxberger , Marion Le Bideau et al.
International Journal of Antimicrobial Agents, 2020, pp.106202. ⟨10.1016/j.ijantimicag.2020.106202⟩
Article dans une revue hal-02996278 v1

Chloroquine as a prophylactic agent against COVID-19?

Mathieu Gendrot , Emilie Javelle , Axelle Clerc , Hélène Savini , Bruno Pradines
International Journal of Antimicrobial Agents, 2020, 55 (6), pp.105980. ⟨10.1016/j.ijantimicag.2020.105980⟩
Article dans une revue hal-02996310 v1
Image document

Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation

Mathieu Gendrot , Julien Andreani , Manon Boxberger , Priscilla Jardot , Isabelle Fonta et al.
Travel Medicine and Infectious Disease, 2020, 37, pp.101873. ⟨10.1016/j.tmaid.2020.101873⟩
Article dans une revue hal-02996300 v1
Image document

In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2

Mathieu Gendrot , Julien Andreani , Priscilla Jardot , Sebastien Hutter , Oceane Delandre et al.
Molecules, 2020, 25 (21), ⟨10.3390/molecules25215064⟩
Article dans une revue hal-03149268 v1

Nucleoside-lipid-based nanocarriers for methylene blue delivery: potential application as anti-malarial drug

Koffi Kowouvi , Bruno Alies , Mathieu Gendrot , Alexandra Gaubert , Gaelle Vacher et al.
RSC Advances, 2019, 9 (33), pp.18844-18852. ⟨10.1039/C9RA02576F⟩
Article dans une revue hal-02165879 v1
Image document

Modulation of in vitro antimalarial responses by polymorphisms in Plasmodium falciparum ABC transporters (pfmdr1 and pfmdr5)

Mathieu Gendrot , Mamadou Wague Gueye , Francis Tsombeng Foguim , Marylin Madamet , Khalifa Ababacar Wade et al.
Acta Tropica, 2019, 196, pp.126-134. ⟨10.1016/j.actatropica.2019.05.020⟩
Article dans une revue hal-02140933 v1
Image document

Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?

Francis Foguim Tsombeng , Mathieu Gendrot , Marie Gladys Robert , Marylin Madamet , Bruno Pradines
Malaria Journal, 2019, 18 (1), pp.285. ⟨10.1186/s12936-019-2916-6⟩
Article dans une revue hal-02272228 v1
Image document

Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs

Francis Tsombeng Foguim , Marie Gladys Robert , Mamadou Wague Gueye , Mathieu Gendrot , Silman Diawara et al.
Malaria Journal, 2019, 18 (1), ⟨10.1186/s12936-019-2919-3⟩
Article dans une revue hal-02408550 v1
Image document

Baseline Ex Vivo and Molecular Responses of Plasmodium fa lciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal

Marie Gladys Robert , Francis Foguim Tsombeng , Mathieu Gendrot , Silman Diawara , Marylin Madamet et al.
Antimicrobial Agents and Chemotherapy, 2019, 63 (5), ⟨10.1128/AAC.02445-18⟩
Article dans une revue hal-02140956 v1
Image document

The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates

Mathieu Gendrot , Francis Tsombeng Foguim , Marie Gladys Robert , Remy Amalvict , Joel Mosnier et al.
Malaria Journal, 2018, 17 (1), pp.108. ⟨10.1186/s12936-018-2252-2⟩
Article dans une revue hal-01780668 v1
Image document

Absence of a High Level of Duplication of the Plasmepsin Gene in Africa

Marie Gladys Robert , Francis Foguim Tsombeng , Mathieu Gendrot , Joel Mosnier , Remy Amalvict et al.
Antimicrobial Agents and Chemotherapy, 2018, 62 (11), ⟨10.1128/AAC.00374-18⟩
Article dans une revue hal-01924107 v1
Image document

Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal

Mathieu Gendrot , Silman Diawara , Marylin Madamet , Mame Bou Kounta , Sebastien Briolant et al.
Antimicrobial Agents and Chemotherapy, 2017, 61 (3), ⟨10.1128/AAC.01183-16⟩
Article dans une revue hal-01521240 v1

ABSENCE OF ASSOCIATION BETWEEN EX VIVO SUSCEPTIBILITY TO PIPERAQUINE AND POLYMORPHISMS IN EXONUCLEASE GENE AND COPY NUMBERS IN PLASMEPSIN 2 GENE IN AFRICAN PLASMODIUM FALCIPARUM ISOLATES

Marylin Madamet , Mathieu Gendrot , Francis Foguim , Gladys Robert , Nicolas Benoit et al.
American Journal of Tropical Medicine and Hygiene, 2017, 97 (5, S), pp.297
Article dans une revue hal-01774368 v1

PROVEBLUE, METHYLENE BLUE, AS AN ANTIMALARIAL DRUG

Bruno Pradines , Mathieu Gendrot , Remy Amalvict , Joel Mosnier , Nicolas Benoit et al.
American Journal of Tropical Medicine and Hygiene, 2017, 97 (5, S), pp.495-496
Article dans une revue hal-01774369 v1

Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal

Mathieu Gendrot , Bécaye Fall , Marylin Madamet , Mansour Fall , Khalifa Ababacar Wade et al.
Antimicrobial Agents and Chemotherapy, 2016, 60 (8), pp.5010-5013. ⟨10.1128/AAC.03105-15⟩
Article dans une revue hal-01455596 v1