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Présentation
After a PhD in bioinformatics on protein structural comparison and classification (2001-2005) at Université Pierre and Marie Curie (UPMC, Paris), I have developed skills in viral metagenomics during my post-doctoral fellowship (ATER, 2005-2006) at Université Denis Diderot (Paris). Since I have been recruted at UPMC (2006), and I have divided my time between teaching algorithmic, programming languages and bioinformatics to students in computer science and students in biology, while performing research in various fields of bioinformatics. I have spent 6 months in 2007 in Stanford (California, USA) as invited researcher at Michael Levitt Lab, working on protein structural classification in order to build a database for fold recognition. I have been the principal investigator of a grant for preliminary studies (PEPS BMI 2013 and 2014) for oceanic metaviromics annotation and analyses presented in a conference and resulted in a publication. I have published several major articles on protein structure analyses as well.
Domaines de recherche
Bio-informatique [q-bio.QM]
Biologie structurale [q-bio.BM]
Génomique, Transcriptomique et Protéomique [q-bio.GN]
Bio-Informatique, Biologie Systémique [q-bio.QM]
Evolution [q-bio.PE]
Systématique, phylogénie et taxonomie
Publications
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Identifying distant homologous viral sequences in metagenomes using protein structure informationECCB'14 Workshop on Recent Computational Advances in Metagenomics, Sep 2014, Strasbourg, France
Communication dans un congrès
hal-01090987v1
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Incremental Inference of Relational Motifs with a Degenerate Alphabet2005, pp.229 - 240
Communication dans un congrès
hal-00077380v1
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Impact of a Point Mutation in a Protein StructurePhilippe Grandcolas; Marie-Christine Maurel. Systematics and the Exploration of Life, 1, Wiley, 2021, 9781119476870. ⟨10.1002/9781119476870.ch2⟩
Chapitre d'ouvrage
mnhn-03959542v1
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Implicit and Explicit Representation of Approximated MotifsC. S. Iliopoulos and K. Park and K. Steinhoefel. Algorithms in Bioinformatics, College Press, pp.1-15, 2006
Chapitre d'ouvrage
hal-00087010v1
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Are protein folds reliable phylogenetic markers?Mathematical and Computational Evolutionary Biology, Jun 2022, Château d'Oex, Switzerland
Poster de conférence
hal-03959674v1
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PPalign: optimal alignment of Potts models representing proteins with direct coupling informationISMB 2022 - 30th Conference on Intelligent Systems for Molecular Biology, Jul 2022, Madison, United States. pp.1-1
Poster de conférence
hal-03926272v1
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La structure des protéines et son évolutionBio-informatique [q-bio.QM]. Sorbonne Université, 2023
HDR
tel-04076823v1
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Méthodes de détection des similarités structurales : caractérisation des motifs conservés dans les familles de structures pour l'annotation des génomesBio-informatique [q-bio.QM]. Université Pierre et Marie Curie (Paris 6), Sorbonne Universités, 2005. Français. ⟨NNT : ⟩
Thèse
tel-03959695v1
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