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Michael O'DONOHUE

Directeur Scientifique du programme EXPLOR'AE (France 2030) Directeur del'infrastructure de recherche européenne IBISBA
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Presentation

Michael O’Donohue travaille à l’INRAE, l'Institut national de recherche pour l'agriculture, l'alimentation et l'environnement. Il est titulaire d'un doctorat en biochimie des protéines de l'Université de Portsmouth (Royaume-Uni) et possède une vaste expérience de recherche en ingénierie enzymatique et en biotechnologie. De 2016 à 2024, Michael a dirigé la division TRANSFORM d’INRAE. Depuis janvier 2024, Michael est directeur scientifique d’EXPLOR’AE, un programme national qui finance la recherche à haut risque et à haute récompense. En 2014, Michael a lancé une initiative européenne visant à fédérer les capacités européennes et à développer une approche plus systémique de la recherche en biotechnologie et en biofabrication. Depuis, cette initiative est devenue IBISBA, une infrastructure de recherche européenne distribuée qui a obtenu la reconnaissance de l'ESFRI en 2018. IBISBA mobilise actuellement le personnel de 23 institutions de recherche situées dans 11 pays européens.

Skills

Mangement d'équipes Coordination de projets interdisciplinaires Gestion stratégique de la recherche

Publications

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Biotech potential set to soar with the help of digital technology

Michael J O'Donohue
Horizon Magazine, 2024, https://projects.research-and-innovation.ec.europa.eu/en/horizon-magazine/biotech-potential-set-soar-help-digital-technology#linkedin
Journal articles hal-04727153v1

Horizontal metaproteomics and CAZymes analysis of lignocellulolytic microbial consortia selectively enriched from cow rumen and termite gut

Emeline Auer , Adèle Lazuka , Bertrand Huguenin-Bizot , Nico Jehmlich , Sébastien Déjean
Isme Communications, 2023, 3, pp.134. ⟨10.1038/s43705-023-00339-0⟩
Journal articles hal-04844011v1
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Regioselective chemo-enzymatic syntheses of ferulate conjugates as chromogenic substrates for feruloyl esterases

Olga Gherbovet , Fernando Ferreira , Apolline Clément , Mélanie Ragon , Julien Durand
Beilstein Journal of Organic Chemistry, 2021, 17, pp.325-333. ⟨10.3762/bxiv.2020.107.v1⟩
Journal articles hal-02988548v2
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Synthesis of α-l-Araf and β-d-Galf series furanobiosides using mutants of a GH51 α-l-arabinofuranosidase

Jiao Zhao , Jérémy Esque , Isabelle André , Michael O'Donohue , Régis Fauré
Bioorganic Chemistry, 2021, 116, pp.105245. ⟨10.1016/j.bioorg.2021.105245⟩
Journal articles hal-03371339v1
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Probing the determinants of the transglycosylation/hydrolysis partition in a retaining α-l-arabinofuranosidase

Jiao Zhao , Tobias Tandrup , Bastien Bissaro , Sophie Barbe , Jens-Christian Poulsen
New Biotechnology, 2021, 62, pp.68-78. ⟨10.1016/j.nbt.2021.01.008⟩
Journal articles hal-03139105v1
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The Jo-In protein welding system is a relevant tool to create CBM-containing plant cell wall degrading enzymes

Louise Badruna , Vincent Burlat , Pierre Roblin , Thomas Enjalbert , Guy Lippens
New Biotechnology, 2021, 65, pp.31-41. ⟨10.1016/j.nbt.2021.07.004⟩
Journal articles hal-03340154v1
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Rational enzyme design without structural knowledge: a sequence-based approach for efficient generation of transglycosylases

David Teze , Jiao Zhao , Mathias Wiemann , Kazi Zubaida Gulshan Ara , Rossana Lupo
Chemistry - A European Journal, inPress, ⟨10.1002/chem.202100110⟩
Journal articles hal-02906907v2

Multimodularity of a GH10 Xylanase Found in the Termite Gut Metagenome

Haiyang Wu , Eleni Ioannou , Bernard Henrissat , Cédric Montanier , Sophie Bozonnet
Applied and Environmental Microbiology, 2021, 87 (3), ⟨10.1128/AEM.01714-20⟩
Journal articles hal-03146857v1
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Waste-to-nutrition: a review of current and emerging conversion pathways

U Javourez , Michael O'Donohue , Lorie Hamelin
Biotechnology Advances, 2021, 53, 26 p. ⟨10.1016/j.biotechadv.2021.107857⟩
Journal articles hal-03426554v1
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Anaerobic lignocellulolytic microbial consortium derived from termite gut: enrichment, lignocellulose degradation and community dynamics

Adèle Lazuka , Lucas Auer , Michael O'Donohue , Guillermina Hernandez Raquet
Biotechnology for Biofuels, 2018, 11 (1), 14 p. ⟨10.1186/s13068-018-1282-x⟩
Journal articles hal-02621415v1
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Meeting new challenges in food science technology: the development of complex systems approach for food and biobased research

Hugo de Vries , Monique Axelos , Pascale Manchado-Sarni , Michael O'Donohue
Innovative Food Science & Emerging Technologies / Innovative Food Science and Emerging Technologies , 2018, 46, pp.1-6. ⟨10.1016/j.ifset.2018.04.004⟩
Journal articles hal-01837847v1
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Developing cellulolytic Yarrowia lipolytica as a platform for the production of valuable products in consolidated bioprocessing of cellulose

Zhongpeng Guo , Julien Robin , Sophie Duquesne , Michael O'Donohue , Alain Marty
Biotechnology for Biofuels, 2018, 11 (1), 15 p. ⟨10.1186/s13068-018-1144-6⟩
Journal articles hal-01886473v1

Biomasse : les enjeux pour l’avenir de la chimie du carbone

Franck Dumeignil , Henri Strub , Hélène Olivier-Bourbigou , Jérôme François , Michael O'Donohue
L'Actualité Chimique, 2018, 427-428, pp.19-24
Journal articles hal-02906921v1

INRA's research in industrial biotechnology: For food, chemicals, materials and fuels

Carole Camarasa , Hubert Chiron , Fayza Daboussi , Guy Della Valle , Claire Dumas
Innovative Food Science & Emerging Technologies / Innovative Food Science and Emerging Technologies , 2018, 46, pp.140-152. ⟨10.1016/j.ifset.2017.11.008⟩
Journal articles hal-03628058v1
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Ecofriendly lignocellulose pretreatment to enhance the carboxylate production of a rumen-derived microbial consortium

Adèle Lazuka , Cécile Roland , Abdellatif Barakat , Fabienne Guillon , Michael O'Donohue
Bioresource Technology, 2017, 236, pp.225-233. ⟨10.1016/j.biortech.2017.03.083⟩
Journal articles hal-01607636v1
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Expressing accessory proteins in cellulolytic Yarrowia lipolytica to improve the conversion yield of recalcitrant cellulose

Zhongpeng Guo , Sophie Duquesne , Sophie Bozonnet , Jean-Marc Nicaud , Alain Marty
Biotechnology for Biofuels, 2017, 10 (1), 16 p. ⟨10.1186/s13068-017-0990-y⟩
Journal articles hal-01886440v1
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Uncovering the potential of termite gut microbiome for lignocellulose bioconversion in anaerobic batch bioreactors

Lucas Auer , Adèle Lazuka , David Sillam-Dussès , Edouard Miambi , Michael O'Donohue
Frontiers in Microbiology, 2017, 8, 14 p. ⟨10.3389/fmicb.2017.02623⟩
Journal articles hal-01886494v1

Analysis of large 16S rRNA Illumina datasets: impact of singleton read filtering on microbial community description

Lucas Auer , Mahendra Mariadassou , Michael O'Donohue , Christophe Klopp , Guillermina Hernandez-Raquet
Molecular Ecology Resources, 2017, ⟨10.1111/1755-0998.12700⟩
Journal articles hal-01605865v1
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Conferring cellulose-degrading ability to Yarrowia lipolytica to facilitate a consolidated bioprocessing approach

Zhongpeng Guo , Sophie Duquesne , Sophie Bozonnet , Gianluca Cioci , Jean-Marc Nicaud
Biotechnology for Biofuels, 2017, 10 (1), pp.13. ⟨10.1186/s13068-017-0819-8⟩
Journal articles hal-01605060v1

Characterization and mutagenesis of two novel iron-sulphur cluster pentonate dehydratases

Martina Andberg , Niina Aro-Karkkainen , Paul Carlson , Merja Oja , Sophie Bozonnet
Applied Microbiology and Biotechnology, 2016, 100 (17), pp.7549-7563. ⟨10.1007/s00253-016-7530-8⟩
Journal articles hal-01886409v1

Design of chromogenic probes for efficient screening and evaluation of feruloyl esterase-like activities

Olga Gherbovet , Régis Fauré , Fernando Ferreira , Julien Durand , Mélanie Ragon
Journal of Molecular Catalysis B: Enzymatic, 2016, 126, pp.24-31. ⟨10.1016/j.molcatb.2016.01.012⟩
Journal articles hal-01450768v1
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A single point mutation alters the transglycosylation/hydrolysis partition, significantly enhancing the synthetic capability of an endo-glycoceramidase

Julien Durand , Xevi Biarnés , Laurie Watterlot , Cyrielle Bonzom , Vinciane Borsenberger
ACS Catalysis, 2016, 6 (12), pp.8264-8275. ⟨10.1021/acscatal.6b02159⟩
Journal articles hal-01606355v1
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The GH51 α-l-arabinofuranosidase from Paenibacillus sp. THS1 is multifunctional, hydrolyzing main-chain and side-chain glycosidic bonds in heteroxylans

Hanen Bouraoui , Marie-Laure Desrousseaux , Eleni Ioannou , Pablo Alvira , Mohamed Manaï
Biotechnology for Biofuels, 2016, 9 (1), pp.1-14. ⟨10.1186/s13068-016-0550-x⟩
Journal articles hal-01595481v1
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CAZyChip: dynamic assessment of exploration of glycoside hydrolases in microbial ecosystems

Anne Abot , Grégory Arnal , Lucas Auer , Adèle Lazuka , Delphine Labourdette
BMC Genomics, 2016, 17 (1), pp.1-12. ⟨10.1186/s12864-016-2988-4⟩
Journal articles hal-01843061v1
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Development of cellobiose-degrading ability in Yarrowia lipolytica strain by overexpression of endogenous genes

Zhongpeng Guo , Sophie Duquesne , Sophie Bozonnet , Gianluca Cioci , Jean-Marc Nicaud
Biotechnology for Biofuels, 2015, 8, pp.1-16. ⟨10.1186/s13068-015-0289-9⟩
Journal articles hal-01185655v1

Enhancing the chemoenzymatic synthesis of arabinosylated xylo-oligosaccharides by GH51 α-l-arabinofuranosidase

Faten Arab-Jaziri , Bastien Bissaro , Charles Tellier , Michel Dion , Régis Fauré
Carbohydrate Research, 2015, 401, pp.64-72. ⟨10.1016/j.carres.2014.10.029⟩
Journal articles hal-02146151v1

White biotechnology: state of the art strategies for the development of biocatalysts for biorefining

Stephanie Heux , Isabelle Meynial Salles , Michael O'Donohue , Claire Dumon
Biotechnology Advances, 2015, 33 (8), ⟨10.1016/j.biotechadv.2015.08.004⟩
Journal articles hal-01269233v1
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Investigating the function of an arabinan utilization locus isolated from a termite gut community

Grégory Arnal , Geraldine Bastien-Uluis , Nelly Monties , Anne Abot , Véronique Le Berre
Applied and Environmental Microbiology, 2015, 81 (1), pp.31-9. ⟨10.1128/AEM.02257-14⟩
Journal articles hal-01269098v1
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Probing the functions of carbohydrate binding Modules in the CBEL protein from the oomycete Phytophthora parasitica

Thomas Martinez , Hélène Texier , Virginie Nahoum , Claude Lafitte , Gianluca Cioci
PLoS ONE, 2015, 10 (9), ⟨10.1371/journal.pone.0137481⟩
Journal articles hal-02635206v1
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Efficient anaerobic transformation of raw wheat straw by a robust cow rumen-derived microbial consortium

Adèle Lazuka , Lucas Auer , Sophie Bozonnet , Diego Morgavi , Michael O'Donohue
Bioresource Technology, 2015, 196, pp.241-249. ⟨10.1016/j.biortech.2015.07.084⟩
Journal articles hal-01269314v1
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Glycosynthesis in a waterworld: new insight into the molecular basis of transglycosylation in retaining glycoside hydrolases

Bastien Bissaro , Pierre Monsan , Régis Fauré , Michael j. O’donohue
Biochemical Journal, 2015, 467 (1), pp.17-35. ⟨10.1042/BJ20141412⟩
Journal articles hal-02146118v1

Molecular design of non-Leloir furanose-transferring enzymes from an α-l-arabinofuranosidase: a rationale for the engineering of evolved transglycosylases

Bastien Bissaro , Julien Durand , Xevi Biarnes , Antoni Planas , Pierre Monsan
ACS Catalysis, 2015, 5 (8), pp.4598-4611. ⟨10.1021/acscatal.5b00949⟩
Journal articles hal-01185302v1
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First Structural Insights into α-l-Arabinofuranosidases from the Two GH62 Glycoside Hydrolase Subfamilies

Béatrice Siguier , Mireille Haon , Virginie Nahoum , Marlène Marcellin , Odile Burlet-Schiltz
Journal of Biological Chemistry, 2014, 289 (8), pp.5261-5273. ⟨10.1074/jbc.M113.528133⟩
Journal articles hal-02419708v1

Mutation of a pH-modulating residue in a GH51 α-l-arabinofuranosidase leads to a severe reduction of the secondary hydrolysis of transfuranosylation products

Bastien Bissaro , Olivier Saurel , Faten Arab-Jaziri , Luc Saulnier , Alain Milon
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (1), pp.626-636. ⟨10.1016/j.bbagen.2013.10.013⟩
Journal articles hal-02146185v1

Biorefineries for food, fuels and materials

Rene Wijffels , Johan Sanders , Ton van Boxtel , Michael O'Donohue
Biofuels, Bioproducts & Biorefining, 2014, 8 (4), pp.453 - 455. ⟨10.1002/bbb.1508⟩
Journal articles hal-01268869v1

Impact of an N-terminal extension on the stability and activity of the GH11 xylanase from Thermobacillus xylanilyticus

Letian Song , Claire Dumon , Béatrice Siguier , Isabelle André , Elena Eneyskaya
Journal of Biotechnology, 2014, 174, pp.64-72. ⟨10.1016/j.jbiotec.2014.01.004⟩
Journal articles hal-01268735v1

A 1H NMR study of the specificity of α-l-arabinofuranosidases on natural and unnatural substrates

Vinciane Borsenberger , Emmie Dornez , Marie-Laure Desrousseaux , Stéphane Massou , Maija Tenkanen
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (10), pp.3106-3114. ⟨10.1016/j.bbagen.2014.07.001⟩
Journal articles hal-02146175v1
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Combined approaches provide an anatomical and transcriptomic fingerprint of maize cell wall digestibility

Mary Sarah-Jane Wong Quai M. S.-J. W. Q. Lam , Yves Martinez , Odile Barbier , Alain Jauneau , Sandrine Balzergue
Maydica, 2013, 58 (1-4), pp.274 - 287
Journal articles hal-01195495v1
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La biomasse, simple source d'énergie ou source de matières premières renouvelables ?

Michael O'Donohue
Innovations Agronomiques, 2013, 26, pp.41-50. ⟨10.17180/dfj4-d146⟩
Journal articles hal-01268036v1

A substrate for the detection of broad specificity alpha-L-arabinofuranosidases with indirect release of a chromogenic group

Vinciane Borsenberger , Emmie Dornez , Marie-Laure Desrousseaux , Christophe M. Courtin , Michael O'Donohue
Tetrahedron Letters, 2013, 54 (24), pp.3063 - 3066. ⟨10.1016/j.tetlet.2013.03.136⟩
Journal articles hal-01268100v1
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Mining for hemicellulases in the fungus-growing termite Pseudacanthotermes militaris using functional metagenomics

Geraldine Bastien-Uluis , Grégory Arnal , Sophie Bozonnet , Sandrine Laguerre-Gheusi , Fernando Ferreira
Biotechnology for Biofuels, 2013, 6, online (may), Non paginé. ⟨10.1186/1754-6834-6-78⟩
Journal articles hal-01268110v1

Engineering transglycosidase activity into a GH51 α-l-arabinofuranosidase

Faten Arab-Jaziri , Bastien Bissaro , Michel Dion , Olivier Saurel , David Harrison
New Biotechnology, 2013, 30 (5), pp.536-544. ⟨10.1016/j.nbt.2013.04.002⟩
Journal articles hal-02146240v1

Paenibacillus marinum sp nov., a thermophilic xylanolytic bacterium isolated from a marine hot spring in Tunisia

Hanene Bouraoui , Hanen Rebib , Melek Ben Aissa , Jean-Pierre Touzel , Michael O'Donohue
Journal of Basic Microbiology, 2013, 53 (11), pp.877 - 883. ⟨10.1002/jobm.201200275⟩
Journal articles hal-01268471v1

Comparison of the Heterologous Expression of Trichoderma reesei Endoglucanase II and Cellobiohydrolase II in the Yeasts Pichia pastoris and Yarrowia lipolytica

Nassapat Boonvitthya , Sophie Bozonnet , Vorakan Burapatana , Michael O'Donohue , Warawut Chulalaksananukul
Molecular Biotechnology, 2013, 54 (2), pp.158 - 169. ⟨10.1007/s12033-012-9557-0⟩
Journal articles hal-01268106v1
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Engineering better biomass-degrading ability into a GH11 xylanase using a directed evolution strategy

Letian Song , Béatrice Siguier , Claire Dumon , Sophie Bozonnet , Michael O'Donohue
Biotechnology for Biofuels, 2012, 5, ⟨10.1186/1754-6834-5-3⟩
Journal articles hal-01268365v1

Redefining XynA from Penicillium funiculosum IMI 378536 as a GH7 cellobiohydrolase

Hélène Texier , Claire Dumon , Virginie Neugnot-Roux , Marc Maestracci , Michael O'Donohue
Journal of Industrial Microbiology and Biotechnology, 2012, 39 (11), pp.1569 - 1576. ⟨10.1007/s10295-012-1166-1⟩
Journal articles hal-01268269v1

Effect of lignin content on a GH11 endoxylanase acting on glucuronoarabinoxylan-lignin nanocomposites

Imen Boukari , Michael O'Donohue , Caroline Rémond , Brigitte Chabbert
Carbohydrate Polymers, 2012, 89, pp.423-431. ⟨10.1016/j.carbpol.2012.03.024⟩
Journal articles hal-02645858v1

A Versatile and Colorful Screening Tool for the Identification of Arabinofuranose-Acting Enzymes

Vinciane Borsenberger , Fernando Ferreira , Annick Pollet , Emmie Dornez , Marie-Laure Desrousseaux
ChemBioChem, 2012, 13 (13), pp.1885 - 1888. ⟨10.1002/cbic.201200394⟩
Journal articles hal-01268282v1
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Thumb-loops up for catalysis: a structure/function investigation of a functional loop movement in a GH11 xylanase

Gabriel Paës , Juan Cortés , Thierry Simeon , Michael O'Donohue , Vinh Tran
Computational and Structural Biotechnology Journal, 2012, 1 (2), pp.e201207001. ⟨10.5936/csbj.201207001⟩
Journal articles hal-01267831v1

Characterization of Deinococcus sahariens sp nov., a radiation-resistant bacterium isolated from a Saharan hot spring

Hanene Bouraoui , Melek Ben Aissa , Feten Abbassi , Jean-Pierre Touzel , Michael O'Donohue
Archives of Microbiology, 2012, 194 (5), pp.315 - 322. ⟨10.1007/s00203-011-0762-1⟩
Journal articles hal-01268345v1

Progress and future prospects for pentose-specific biocatalysts in biorefining

Claire Dumon , Letian Song , Sophie Bozonnet , Régis Fauré , Michael O'Donohue
Process Biochemistry, 2012, 47 (3), pp.346 - 357. ⟨10.1016/j.procbio.2011.06.017⟩
Journal articles hal-01268406v1

Biomass-derived pentoses

Michael O'Donohue , Bärbel Hahn-Hägerdal
Process Biochemistry, 2012, 47 (3), pp.345. ⟨10.1016/j.procbio.2011.10.021⟩
Journal articles hal-01268458v1

Functional roles of H98 and W99 and beta 2 alpha 2 loop dynamics in the alpha-L-arabinofuranosidase from Thermobacillus xylanilyticus

Faten Arab , Bastien Bissaro , Sophie Barbe , Olivier Saurel , Helene Debat
FEBS Journal, 2012, 279 (19), pp.3598 - 3611. ⟨10.1111/j.1742-4658.2012.08720.x⟩
Journal articles hal-01268289v1

Des déchets agricoles pour produire carburants et plastiques verts

Pierre Le Hir , Michael O'Donohue , Michel Delmas , Yvonne Goncalves
Le Monde, 2011
Journal articles hal-02644127v1

Probing a family GH11 endo-beta-1,4-xylanase inhibition mechanism by phenolic compounds: Role of functional phenolic groups

Imen Boukari , Michael O Donohue , Caroline Rémond , Brigitte Chabbert
Journal of Molecular Catalysis B: Enzymatic, 2011, 72 (3-4), pp.130-138. ⟨10.1016/j.molcatb.2011.05.010⟩
Journal articles hal-02649536v1

A high-throughput screening system for the evaluation of biomass-hydrolyzing glycoside hydrolases

Letian Song , S. Laguerre , C. Dumon , Sophie Bozonnet , Michael O'Donohue
Bioresource Technology, 2010, 101 (21), pp.8237 - 8243. ⟨10.1016/j.biortech.2010.05.097⟩
Journal articles hal-02659454v1

Caldimonas hydrothermale sp. nov., a novel thermophilic bacterium isolated from Roman hot bath in south Tunisia

Hanene Bouraoui , Imen Boukari , Jean-Pierre Touzel , Michael O'Donohue , Mohamed Manaï
Archives of Microbiology, 2010, 192 (6), pp.485-91. ⟨10.1007/s00203-010-0576-6⟩
Journal articles hal-02658825v1
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A brief and informationally rich naming system for oligosaccharide motifs of heteroxylans found in plant cell walls

R. Faure , C.M. Courtin , J.A. Delcour , C. Dumon , C.B. Faulds
Australian Journal of Chemistry, 2009, 62, pp.533-537. ⟨10.1071/CH08458⟩
Journal articles hal-00396624v2

Biocatalytic conversion of wheat bran hydrolysate using an immobilized GH43 beta-xylosidase

Issam Smaali , Caroline Rémond , Yousr Skhiri , Michael O Donohue
Bioresource Technology, 2009, 100 (1), pp.338-344. ⟨10.1016/j.biortech.2008.06.041⟩
Journal articles hal-02663118v1

Evaluation of the transglycosylation activities of a GH 39 beta-D-xylosidase for the synthesis of xylose-based glycosides

M. Muzard , Nathalie Aubry , R. Plantier-Royon , Michael O Donohue , Caroline Rémond
Journal of Molecular Catalysis B: Enzymatic, 2009, 58 (1-4), pp.1-5. ⟨10.1016/j.molcatb.2008.10.004⟩
Journal articles hal-02667032v1

In vitro model assemblies to study the impact of lignin-carbohydrate interactions on the enzymatic conversion of Xylan

Imen Boukari , Jean-Luc Putaux , Bernard Cathala , Abdellatif Barakat , Bodo Saake
Biomacromolecules, 2009, 10 (9), pp.2489-2498. ⟨10.1021/bm9004518⟩
Journal articles hal-02666812v1

The complex between a branched pentasaccharide and Thermobacillus xylanilyticus arabinofuranosidase

M. Gajhede , G. Paes , Michael O'Donohue , L.K. Skov , J.S. Kastrup
Acta Crystallographica Section A : Foundations of Crystallography [1968-2013], 2008, 64 (a1), pp.C283-C283. ⟨10.1107/S0108767308090946⟩
Journal articles hal-03146868v1

La production de carburants à partir de biomasse lignocellulosique par voie biologique : état de l’art et perspectives

Michael O'Donohue
Oléagineux, Corps Gras, Lipides, 2008, 15 (3), pp.172-177. ⟨10.1051/ocl.2008.0190⟩
Journal articles hal-02908301v1

Action of a GH51 alpha-L-arabinofuranosidase on wheat derived arabinoxylans and arabino-xylooligosaccharides.

Caroline Rémond , Imen Boukari , G. Chambat , Michael O Donohue
Carbohydrate Polymers, 2008, 72 (3), pp.424-430. ⟨10.1016/j.carbpol.2007.09.008⟩
Journal articles hal-02663477v1

The Structure of the Complex between a Branched Pentasaccharide and Thermobacillus xylanilyticus GH-51 Arabinofuranosidase Reveals Xylan-Binding Determinants and Induced Fit

Gabriel Paës , Lars Skov , Michael O Donohue , Caroline Rémond , Jette Kastrup
Biochemistry, 2008, 47 (28), pp.7441-7451. ⟨10.1021/bi800424e⟩
Journal articles hal-02668354v1

New chromogenic substrates for feruloyl esterases

Laurence Marmuse , Michèle Asther , Emeline Fabre , David Navarro , Laurence Lesage-Meessen
Organic & Biomolecular Chemistry, 2008, 6 (7), pp.1208. ⟨10.1039/b717742a⟩
Journal articles hal-02655815v1

New insights into the role of the thumb-like loop in GH-11 xylanases

Gabriel Paës , Vinh Tran , Masayuki Takahashi , Imen Boukari , Michael O Donohue
Protein Engineering, Design and Selection, 2007, 20 (1), pp.15-23. ⟨10.1093/protein/gzl049⟩
Journal articles hal-02659467v1

Investigation of the specificity of an alpha-L-arabinofuranosidase using C-2 and C-5 modified alpha-L-arabinofuranosides

Gérald Lopez , Caroline Nugier-Chauvin , Caroline Rémond , Michael O Donohue
Carbohydrate Research, 2007, 342 (15), pp.2202-2211. ⟨10.1016/j.carres.2007.06.001⟩
Journal articles hal-02659822v1

Thioimidoyl furanosides as first inhibitors of the α-l-arabinofuranosidase AbfD3

Gérald Lopez , Richard Daniellou , Michael O'Donohue , Vincent Ferrières , Caroline Nugier-Chauvin
Bioorganic and Medicinal Chemistry Letters, 2007, 17 (2), pp.434-438. ⟨10.1016/j.bmcl.2006.10.032⟩
Journal articles hal-00405292v1

Adaptation des procédés, biotechnologies blanches

Michael O'Donohue , Pierre Monsan
Biofutur, 2007
Journal articles hal-02908307v1

Engineering increased thermostability in the thermostable GH-11 xylanase from Thermobacillus xylanilyticus

Gabriel Paës , Michael O Donohue
Journal of Biotechnology, 2006, 125 (3), pp.338-350. ⟨10.1016/j.jbiotec.2006.03.025⟩
Journal articles hal-02660155v1

Expression in Escherichia coli and characterization of beta-xylosidases GH-39 and GH-43 from Bacillus halodurans C-125

Issam Smaali , Caroline Rémond , Michael O Donohue
Applied Microbiology and Biotechnology, 2006, 73 (3), pp.582-590. ⟨10.1007/s00253-006-0512-5⟩
Journal articles hal-02660151v1

Probing the cell-wall heterogeneity of micro-dissected wheat caryopsis using well-characterized active and non-active GH11 xylanases

Johnny Beaugrand , Gabriel Paës , Danièle Reis , Masayuki Takahashi , Philippe Debeire
Planta, 2005, 222 (2), pp.246-257. ⟨10.1007/s00425-005-1538-0⟩
Journal articles hal-02675507v1

An original chemoenzymatic route for the synthesis of β-D-galactofuranosides using an α-L-arabinofuranosidase

Caroline Rémond , Richard Plantier-Royon , Nathalie Aubry , Michael O Donohue
Carbohydrate Research, 2005, 340 (4), pp.637-644. ⟨10.1016/j.carres.2005.01.016⟩
Journal articles hal-02678181v1

A chemoenzymatic approach for the synthesis of unnatural dissacharides containing D-galacto- or D-fucofuranosides

Ronan Euzen , Gérald Lopez , Caroline Nugier-Chauvin , Vincent Ferrières , Daniel Plusquellec
Global Change Biology, 2005, 2005 (22), pp.4860-4869. ⟨10.1002/ejoc.200500525⟩
Journal articles hal-02682640v1

Impact and efficiency of GH10 and GH11 thermostable endoxylanases on wheat bran and alkali-extractable arabinoxylans

Johnny Beaugrand , Gérard Chambat , Vicky W.K. Wong , Florence Goubet , Caroline Rémond
Carbohydrate Research, 2004, 339 (15), pp.2529-2540. ⟨10.1016/j.carres.2004.08.012⟩
Journal articles hal-02681326v1

Synthesis of pentose-containing disaccharides using a thermostable α-l-arabinofuranosidase

Caroline Rémond , Richard Plantier-Royon , Nathalie Aubry , Emmanuel Maes , Christophe C. Bliard
Carbohydrate Research, 2004, 339 (11), pp.2019-2025. ⟨10.1016/j.carres.2004.04.017⟩
Journal articles hal-02073657v1

Bioinformatics of the family 57 glycoside hydrolases and identification of catalytic residues in amylopullulanase from Thermococcus hydrothermalis

Richard Zona , Florent Chang-Pi-Hin , Michael O Donohue , Stefan Janecek
European Journal of Biochemistry, 2004, 271 (14), pp.2863-2872. ⟨10.1111/j.1432-1033.2004.04144.x⟩
Journal articles hal-02683580v1

A versatile assay for the accurate, time-resolved determination of cellular viability

Toyoki Amano , Ken-Ichi Hirasawa , Michael O'Donohue , J Claude Pernollet , Yuzo Shioi
Analytical Biochemistry, 2003, 314 (1), pp.1-7
Journal articles hal-02672643v1

Chemoenzymatic syntheses of linear and branched hemithio-maltodextrins as potential inhibitors for starch debranching enzymes

L. Greffe , M.T. Jensen , F. Chang-Pi-Hin , S. Fruchard , M.J. O'Donohue
Chemistry - A European Journal, 2002, pp.5447-5455
Journal articles hal-00307306v1

Probing the catalytically essential residues of the α-l-arabinofuranosidase from Thermobacillus xylanilyticus

Takoua Debeche , Christophe C. Bliard , Philippe Debeire , Michael O'Donohue
Protein Engineering, Design and Selection, 2002, 15 (1), pp.21-28. ⟨10.1093/protein/15.1.21⟩
Journal articles hal-02074537v1

Thermobacillus xylanilyticus gen. nov., sp. nov., a new aerobic thermophilic xylan-degrading bacterium isolated from farm soil

J.P. Touzel , Michael O'Donohue , Philippe Debeire , E. Samain , C. Breton
International Journal of Systematic and Evolutionary Microbiology, 2000, 50, pp.315-320
Journal articles hal-02696650v1

Genetic and Biochemical Characterization of a Highly Thermostable α-l-Arabinofuranosidase fromThermobacillus xylanilyticus

Takoua Debeche , Nicola Cummings , Ian Connerton , Philippe Debeire , Michael O'Donohue
Applied and Environmental Microbiology, 2000, 66 (4), pp.1734-1736. ⟨10.1128/AEM.66.4.1734-1736.2000⟩
Journal articles hal-02908292v1

The type II pullulanase of Thermococcus hydrothermalis : Molecular characterization of the gene and expression of the catalytic domain

M. Erra-Pujada , Philippe Debeire , Francis Duchiron , Michael O'Donohue
Journal of Bacteriology, 1999, 181 (10), pp.3284-3287
Journal articles hal-02697820v1

A novel elicitin necrotic site revealed by alpha-cinnamomin sequence and site-directed mutagenesis

V. Perez , J.C. Huet , Michael O'Donohue , Claude Nespoulous , J.C. Pernollet
Phytochemistry, 1999, 50 (6), pp.961-966
Journal articles hal-02689192v1

The 2.1 A structure of an elicitin-ergosterol complex: a recent addition to the sterol carrier protein family

G. Boissy , Michael O'Donohue , O. Gaudemer , V. Perez , J.C. Pernollet
Protein Science, 1999, 8, pp.1191-1199
Journal articles hal-02695917v1

Phytophthora resistance through production of a fungal protein elicitor (beta-cryptogein) in tobacco

David Tepfer , C. Boutteaux , C. Vigon , S. Aymes , V. Perez
Molecular Plant-Microbe Interactions, 1998, 11 (1), pp.64-67
Journal articles hal-02689195v1
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Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.

Cynthia Marie-Claire , Emmanuel Ruffet , Serge Antonczak , Ann Beaumont , Michael O'Donohue
Biochemistry, 1997, 36 (45), pp.13938-45. ⟨10.1021/bi9712495⟩
Journal articles inserm-00171023v1

A method for introducing site-specific mutations using oligonucleotide primers and its application to site-saturation mutagenesis

M.J. O'Donohue , G.G. Kneale
Molecular Biotechnology, 1996, 6, pp.179-189
Journal articles hal-02691266v1
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The roles of the prosequence of thermolysin in enzyme inhibition and folding in vitro

Michael O'Donohue , Ann Beaumont
Journal of Biological Chemistry, 1996, 271 (43), pp.26477-26481. ⟨10.1074/jbc.271.43.26477⟩
Journal articles hal-02695052v1

Overexpression in Pichia pastoris and Crystallization of an Elicitor Protein Secreted by the Phytopathogenic Fungus, Phytophthora cryptogea

Michael O'Donohue , Guillaume Boissy , Jean-Claude Huet , Claude Nespoulous , Simone Brunie
Protein Expression and Purification, 1996, 8 (2), pp.254-261. ⟨10.1006/prep.1996.0098⟩
Journal articles hal-02906918v1

Chemical synthesis, expression and mutagenesis of a gene encoding B-cryptogein, an elicitin produced by Phytophthora cryptogea

M.J. O'Donohue , H. Gousseau , J.C. Huet , David Tepfer , J.C. Pernollet
Plant Molecular Biology, 1995, 27 (3), pp.577-586. ⟨10.1007/BF00019323⟩
Journal articles hal-02700301v1
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The role of histidine 231 in thermolysin-like enzymes

Ann Beaumont , Michael O'Donohue , Nathalie Paredes , Nathalie Rousselet , Marcel Assicot
Journal of Biological Chemistry, 1995, 270 (28), pp.16803-16808. ⟨10.1074/jbc.270.28.16803⟩
Journal articles hal-02711870v1

Cloning and expression in Bacillus subtilis of the npr gene from Bacillus thermoproteolyticus Rokko coding for the thermostable metalloprotease thermolysin

Michael O'Donohue , B. Roques , A. Beaumont
Biochemical Journal, 1994, 300 (2), pp.599-603. ⟨10.1042/bj3000599⟩
Journal articles hal-02906914v1

Identification and Characterization of Various Cholecystokinin B Receptor mRNA Forms in Rat Brain Tissue and Partial Determination of the Cholecystokinin B Receptor Gene Structure

A. Jagerschmidt , T. Popovici , Michael O'Donohue , B. Roques
Journal of Neurochemistry, 1994, 63 (4), pp.1199-1206. ⟨10.1046/j.1471-4159.1994.63041199.x⟩
Journal articles hal-02906916v1

Tyr26 and Phe73 are essential for full biological activity of the Fd Gene 5 protein

M.J. O'Donohue , G.P. Scarlett , G.G. Kneale
FEMS Microbiology Letters, 1993, 109 (2-3), pp.219-223. ⟨10.1111/j.1574-6968.1993.tb06171.x⟩
Journal articles hal-02906915v1

Dynamic Hybrid Model for Nanobody-based Antivenom Production (scorpion antivenon) with E. coli CH10-12 and E. coli NbF12-10

David Camilo Corrales , Susana María Alonso Villela , Balkiss Bouhaouala-Zahar , Julien Cescut , Fayza Daboussi
34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, 53, Elsevier, pp.145-150, 2024, Computer Aided Chemical Engineering, ⟨10.1016/B978-0-443-28824-1.50025-9⟩
Book sections hal-04642732v1
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Le biosourcé va-t-il verdir le bâtiment

Michael O'Donohue , Monique Axelos , Sarah-Louise Filleux , Chavance Yann , Lerayer Pierre-Yves
"Ressources" n°3, la revue INRAE, 3, pp.66-85, 2023, ⟨10.17180/T5CZ-WM26⟩
Book sections hal-03959362v1

Les biotechnologies industrielles : plaque tournante à la croisée des IAA et de la chimie verte

Cédric Montanier , Michael O'Donohue
Chimie verte et industries agroalimentaires - Vers une bioéconomie durable, 2020
Book sections hal-02889114v1

Industrial biotechnology in the food and feed sector

Michael O'Donohue , Pierre Monsan
Industrial biotechnology : sustainable growth and economic success, Wiley-VCH, 522 p., 2010, 978-3-527-31442-3
Book sections hal-02820702v1

Fractionnement de la biomasse lignocellulosique : production de produits chimiques de bases

Michael O'Donohue , Philippe Debeire
La chimie verte, 2006
Book sections hal-02908325v1

Primer-directed site-specific mutagenesis

Michael O'Donohue , G. Geoff Geoff Kneale
The nucleic acid protocols handbook, 2000
Book sections hal-02908333v1