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Nathalie Mignet

115
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CNRS Research Director National Scientific Research Center (CNRS) - France. Born 01/10/1970 •Leader of the laboratory: UTCBS: Unité des Technologies Chimiques et Biologiques pour la Santé Team Leader of the team Vector for Molecular Imaging and targeted therapy in UTCBS Université de Paris - UMR 8258 - CNRS – UMR-S 1267 Inserm **Main scientific field and domain of competence**: - Nanomedicine, non viral vectors for gene delivery, liposomes - Biomaterials - Drug delivery - Cancer therapy – Nanovectors characterisation – Bioimaging, optical imaging techniques. - Main work patents and discoveries concern gene delivery vectors, including chemical vectors delivery methods, new characterisation methods, pharmacokinetic and bioimaging. ****Scientific Publications:**** - h index: 30 (1997-) - 3351 quotations - 86 articles in reviewed journals or book chapters. - 26 reviews or books chapters - 11 independent patent applications - 26 invited speaker lectures in International Meetings - Editor for Elsevier of 3 special issues in International Journal of Pharmaceutics, 2 for Frontiers in chemistry - Editorial Board of Nanomedicine, Drug Delivery and Translational Research, Pharmaceutics, Nanotheranostics **Diplomas** - 2008: Habilitation to lead research - 1996: PhD in bio-organic chemistry, montpellier, France **Scientific Responsibilities (present time):** - 2019-ongoing: Lab leader: UTCBS - 2014 – ongoing: Team Leader Vectors for Molecular Imaging and Targeted Therapies - 2019- Member of the ITMO Heath Technologies Council - 2014-2020: Founder and president of the French Society for Nanomedicine - 2021- Elected Member of the INSERM Scientific commission - 2021-Committee Member for the National Research Agency - 2017-2018: Committee member for the National Council Research of Norway - 2015-2019: Committee Member for the National Ligue against Cancer (La Ligue) - 2013-2016: Committee member for the national Research Agency. - 2017: Working Group member on Nanomedicine for the Alliance Aviesan - 2016 Working group member for the Pharmaceutical center prospective 10 Major publications: 1. V. Baldim, F. Bedioui, N. Mignet, I. Margaill, J.-F. Berret Ce3+-surface density superposition principle observed for CeO2-x superoxide dismutase and catalase-like catalytic activities Nanoscale 2018, 10(15):6971-6980. 2\. Zeng N., Seguin J., Dumortier G., Maury M., Bessodes M., Scherman D., Mignet N., Boudy V. Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: in vitro and in vivo validation of a sustained buccal drug delivery Int J Pharm 2017, 534(1-2):128-135. 3\. Ramírez-García G, Gutiérrez-Granados S, Gallegos-Corona MA, Palma-Tirado L, d'Orlyé F, Varenne A, Mignet N, Richard C, Martínez-Alfaro M. Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice. Int J Pharm. 2017, 532, 686-695. 4 Valero L, Alhareth K, Gil S, Simasotchi C, Roques C, Scherman D, Mignet N, Fournier T, Andrieux K. Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo models: the dually perfused human placenta and the suspended villous explants. Int J Pharm. 2017, 532(2):729-737 5 Manta S, Renault G, Delalande A, Couture O, Lagoutte I, Seguin J, Lager F, Houzé P, Midoux P, Bessodes M, Scherman D, Bureau MF, Marie C, Pichon C, Mignet, N. Cationic Microbubbles and Antibiotic-Free Plasmid for sustained Ultrasound-mediated Transgene Expression in liver. J. Controlled Rel. 2017, 262:170-181 6 Ramírez-García G, d'Orlyé F, Gutiérrez-Granados S, Martínez-Alfaro M, Mignet N, Richard C, Varenne A. Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis. Colloids Surf B Biointerfaces. 2015, 136, 272-281 7\. Zeng N., Mignet N, Dumortier G, Olivier E, Seguin J, Maury M, Scherman D, Rat P, Boudy V.Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line International Journal of Pharmaceutics, Int J. Pharm. 2015, 495, 1028-37. 8\. Seguin J, Dhotel H, Kai-Luen R, Bessodes M, Mignet N. Fine tuning of mixed ionic and hydrogen bond interactions for plasmid delivery using lipoplexes. Eur J Pharm Biopharm. 2015, 90, 63-9. 9\. M. Breton, J.F. Berret, C. Bourgaux, T. Kral, M. Hof, C. Pichon, M. Bessodes, D. Scherman, N. Mignet, Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly. Langmuir, 2011, 27, 12336-45 10\. G. Pembouong, N. Morellet, T. Kral, M. Hof, D. Scherman, M-F. Bureau, N. Mignet, Triblock copolymer L64 destabilizes lipidic membranes and does not interact with DNA J. Controlled Release, 2011, 151, 57-64

Publications

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Influence of Liposomes’ and Lipoplexes’ Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta

Louise Fliedel , Khair Alhareth , Johanne Seguin , Marwa El-Khashab , Audrey Chissey
International Journal of Molecular Sciences, 2022, 23 (11), pp.6299. ⟨10.3390/ijms23116299⟩
Journal articles hal-03712180v1

Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up

Thomas Lécuyer , Johanne Seguin , Alice Balfourier , Marine Delagrange , Pierre Burckel
Nanoscale, 2022, 14 (42), pp.15760-15771. ⟨10.1039/d2nr03546d⟩
Journal articles hal-03872190v1
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Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders

Louise Fliedel , Khair Alhareth , Nathalie Mignet , Thierry Fournier , Karine Andrieux
Biomedicines, 2022, 10 (5), pp.936. ⟨10.3390/biomedicines10050936⟩
Journal articles hal-04111898v1
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Influence of Liposomes’ and Lipoplexes’ Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta

Louise Fliedel , Khair Alhareth , Johanne Seguin , Marwa El-Khashab , Audrey Chissey
International Journal of Molecular Sciences, 2022, 23 (11), pp.6299. ⟨10.3390/ijms23116299⟩
Journal articles hal-04111923v1
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In vivo ultrasound modulated optical tomography with a persistent spectral hole burning filter

Quang Minh Thai , Ghadir Kalot , Caroline Venet , Johanne Seguin , Maïmouna Bocoum
Biomedical optics express, 2022, 13, ⟨10.1364/boe.475449⟩
Journal articles hal-03903719v1
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New Preservative-Free Formulation for the Enhanced Ocular Bioavailability of Prostaglandin Analogues in Glaucoma

Gabriel Alviset , Yohann Corvis , Karim Hammad , Josiane Lemut , Marc Maury
Pharmaceutics, 2022, 14 (2), pp.453. ⟨10.3390/pharmaceutics14020453⟩
Journal articles hal-03705031v1

Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour

Thomas Lécuyer , Nicolas Bia , Pierre Burckel , Cédric Loubat , Alain Graillot
Nanoscale, 2022, ⟨10.1039/D1NR07114A⟩
Journal articles hal-03528462v1
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Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy

Panpan Ma , Johanne Seguin , Nhu Ky Ly , Luis Castillo Henríquez , Eva Plansart
International Journal of Pharmaceutics: X, 2022, 4, pp.100138. ⟨10.1016/j.ijpx.2022.100138⟩
Journal articles hal-03861933v1

Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up

Thomas Lécuyer , Johanne Seguin , Alice Balfourier , Marine Delagrange , Pierre Burckel
Nanoscale, 2022, ⟨10.1039/d2nr03546d⟩
Journal articles hal-03827771v1

Co–encapsulation of flavonoids with anti–cancer drugs: A challenge ahead

Nathalie Mignet , Johanne Seguin , Khair Alhareth , Muriel Paul , Karine Andrieux
International Journal of Pharmaceutics, 2022, 623, pp.121942. ⟨10.1016/j.ijpharm.2022.121942⟩
Journal articles hal-03882629v1
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How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy?

Marinella Difonzo , Louise Fliedel , Nathalie Mignet , Khair Alhareth , Karine Andrieux
Sci, 2022, 4 (1), pp.11. ⟨10.3390/sci4010011⟩
Journal articles hal-03712176v1
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Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up

Thomas Lécuyer , Johanne Seguin , Alice Balfourier , Marine Delagrange , Pierre Bürckel
Nanoscale, 2022, 14 (42), pp.15760-15771. ⟨10.1039/d2nr03546d⟩
Journal articles hal-03875269v1
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Designing fisetin nanocrystals for enhanced in cellulo anti-angiogenic and anticancer efficacy

Panpan Ma , Johanne Seguin , Nhu Ky Ly , Luis Castillo Henríquez , Eva Plansart
International Journal of Pharmaceutics: X, 2022, 4, pp.100138. ⟨10.1016/j.ijpx.2022.100138⟩
Journal articles hal-04090295v1

Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up

Thomas Lécuyer , Johanne Seguin , Alice Balfourier , Marine Delagrange , Pierre Burckel
Nanoscale, inPress, ⟨10.1039/d2nr03546d⟩
Journal articles hal-03828116v1
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Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders

Louise Fliedel , Khair Alhareth , Nathalie Mignet , Thierry Fournier , Karine Andrieux
Biomedicines, 2022, 10 (5), pp.936. ⟨10.3390/biomedicines10050936⟩
Journal articles hal-03712174v1

Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour

Thomas Lécuyer , Nicolas Bia , Pierre Burckel , Cédric Loubat , Alain Graillot
Nanoscale, 2022, 14 (4), pp.1386-1394. ⟨10.1039/d1nr07114a⟩
Journal articles hal-03872183v1
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How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy?

Marinella Difonzo , Louise Fliedel , Nathalie Mignet , Karine Andrieux , Khair Alhareth
Sci, 2022, 4 (1), pp.11. ⟨10.3390/sci4010011⟩
Journal articles hal-04111958v1
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Electrokinetic elucidation of the interactions between persistent luminescent nanoprobes and the binary apolipoprotein-E/albumin protein system

Gonzalo Ramírez García , Fanny d'Orlyé , Cyrille Richard , Nathalie Mignet , Anne Varenne
Analyst, 2021, 146 (17), pp.5245-5254. ⟨10.1039/d1an00781e⟩
Journal articles hal-03482252v1
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Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour

Thomas Lécuyer , Nicolas Bia , Pierre Burckel , Cédric Loubat , Alain Graillot
Nanoscale, 2021, 14, pp.1386 - 1394. ⟨10.1039/d1nr07114a⟩
Journal articles hal-03875283v1
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Antioxidant activity and toxicity study of cerium oxide nanoparticles stabilized with innovative functional copolymers

Geoffroy Goujon , Victor Baldim , Caroline Roques , Nicolas Bia , Johanne Seguin
Advanced Healthcare Materials, 2021, 10 (11), pp.2100059. ⟨10.1002/adhm.202100059⟩
Journal articles hal-03452741v1
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Co-Encapsulation of Fisetin and Cisplatin into Liposomes for Glioma Therapy: From Formulation to Cell Evaluation

Morgane Renault-Mahieux , Victoire Vieillard , Johanne Seguin , Philippe Espeau , Dang Tri Le
Pharmaceutics, 2021, 13, ⟨10.3390/pharmaceutics13070970⟩
Journal articles hal-03423934v1
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Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged

Shayan Ahmed , Hugo Salmon , Nicholas Distasio , Hai Doan Do , Daniel Scherman
Pharmaceutics, 2021, 13 (4), ⟨10.3390/pharmaceutics13040479⟩
Journal articles hal-03290555v1
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Contribution of Nanotechnologies to Vaccine Development and Drug Delivery against Respiratory Viruses

Mahdi Ftouh , Nesrine Kalboussi , Nabil Abid , Souad Sfar , Nathalie Mignet
PPAR Research, 2021, 2021, pp.1-28. ⟨10.1155/2021/6741290⟩
Journal articles hal-03423555v1
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Combination of tumor cell anti-adhesion and anti-tumor effect to prevent recurrence after cytoreductive surgery in a mice model

Johanne Seguin , Cynthia Pimpie , Petronille Roy , Chantal Al Sabbagh , Marc Pocard
European Journal of Pharmaceutics and Biopharmaceutics, 2021, 169, pp.37-43. ⟨10.1016/j.ejpb.2021.01.020⟩
Journal articles hal-03290586v1

Co-Encapsulation of Fisetin and Cisplatin into Liposomes for Glioma Therapy: From Formulation to Cell Evaluation

Morgane Renault-Mahieux , Victoire Vieillard , Johanne Seguin , Philippe Espeau , Dang Tri Le
Pharmaceutics, 2021, 13, ⟨10.3390/pharmaceutics13070970⟩
Journal articles hal-04119735v1
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Drug delivery systems to prevent peritoneal metastasis after surgery of digestives or ovarian carcinoma: A review

Petronille Roy , Nathalie Mignet , Marc Pocard , Vincent Boudy
International Journal of Pharmaceutics, 2021, 592, ⟨10.1016/j.ijpharm.2020.120041⟩
Journal articles hal-03290554v1

Comprehensive and quantitative stability study of ascorbic acid using capillary zone electrophoresis with ultraviolet detection and high-resolution tandem mass spectrometry

Pauline Legrand , Rabah Gahoual , Raphael Benattar , Balthazar Toussaint , Caroline Roques
Journal of Separation Science, 2020, 43 (14), pp.2925-2935. ⟨10.1002/jssc.202000389⟩
Journal articles hal-03289975v1
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Editorial: Supramolecular Nanomaterials for Engineering, Drug Delivery, and Medical Applications

Elise Lepeltier , Vincent Levet , Tu Lee , Nathalie Mignet , Jianliang Shen
Frontiers in Chemistry, 2020, 8, pp.626468. ⟨10.3389/fchem.2020.626468⟩
Journal articles hal-03050105v1
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In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics

Pierre-Louis Destruel , Ni Zeng , Françoise Brignole-Baudouin , Sophie Douat , Johanne Seguin
Pharmaceutics, 2020, 12 (4), pp.360. ⟨10.3390/pharmaceutics12040360⟩
Journal articles hal-02798293v1
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Theranostic MRI liposomes for magnetic targeting and ultrasound triggered release of the antivascular CA4P

Caroline J Thébault , Grégory Ramniceanu , Sarah Boumati , Aude Michel , Johanne Seguin
Journal of Controlled Release, 2020, 322, pp.137-148. ⟨10.1016/j.jconrel.2020.03.003⟩
Journal articles hal-03059422v1
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Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose: Innovative rheological characterization, in vitro and in vivo evidence of a sustained precorneal retention time

Pierre-Louis Destruel , Ni Zeng , Johanne Seguin , Sophie Douat , Frederic Rosa
International Journal of Pharmaceutics, 2020, 574, pp.118734. ⟨10.1016/j.ijpharm.2019.118734⟩
Journal articles hal-03290593v1
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Thermosensitive hydrogels for local delivery of 5-fluorouracil as neoadjuvant or adjuvant therapy in colorectal cancer

Chantal Al Sabbagh , Johanne Seguin , Elena Agapova , Dounia Kramerich , Vincent Boudy
European Journal of Pharmaceutics and Biopharmaceutics, 2020, 157, pp.154-164. ⟨10.1016/j.ejpb.2020.10.011⟩
Journal articles hal-03290582v1
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Coating Persistent Luminescence Nanoparticles With Hydrophilic Polymers for in vivo Imaging

Jianhua Liu , Lenka Kotrchová , Thomas Lécuyer , Yohann Corvis , Johanne Seguin
Frontiers in Chemistry, 2020, 8, pp.584114. ⟨10.3389/fchem.2020.584114⟩
Journal articles hal-03084996v1
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Advancement in nanogel formulations provides controlled drug release

Shayan Ahmed , Khair Alhareth , Nathalie Mignet
International Journal of Pharmaceutics, 2020, 584, pp.119435 -. ⟨10.1016/j.ijpharm.2020.119435⟩
Journal articles hal-03490686v1
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Development of Theranostic Cationic Liposomes Designed for Image-Guided Delivery of Nucleic Acid

Hai Doan Do , Hai Doan Do , Christine Ménager , Aude Michel , Johanne Seguin
Pharmaceutics, 2020, 12 (9), pp.854. ⟨10.3390/pharmaceutics12090854⟩
Journal articles hal-03059436v1
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Kinetic and structural characterization of therapeutic albumin chemical functionalization using complementary mass spectrometry techniques

Rabah Gahoual , Gérard Bolbach , Ikram Ould-Melha , Gilles Clodic , Yannis Francois
Journal of Pharmaceutical and Biomedical Analysis, 2020, 185, pp.113242. ⟨10.1016/j.jpba.2020.113242⟩
Journal articles hal-03022806v1
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Mucoadhesive thermosensitive hydrogel for the intra-tumoral delivery of immunomodulatory agents, in vivo evidence of adhesion by means of non-invasive imaging techniques

Katia Lemdani , Johanne Seguin , Christelle Lesieur , Chantal Al Sabbagh , Bich-Thuy Doan
International Journal of Pharmaceutics, 2019, 567, pp.118421. ⟨10.1016/j.ijpharm.2019.06.012⟩
Journal articles hal-02325457v1

State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation

Brice Martin Couillaud , Philippe Espeau , Nathalie Mignet , Yohann Corvis
ChemMedChem, 2019, 14 (1), pp.8-23. ⟨10.1002/cmdc.201800612⟩
Journal articles hal-02123129v1
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AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

François Lux , Vu Long Tran , Eloise Thomas , Sandrine Dufort , Fabien Rossetti
British Journal of Radiology, 2019, 92 (1093), pp.20180365. ⟨10.1259/bjr.20180365⟩
Journal articles hal-01935540v1

Degradation of ZnGa2O4:Cr3+ luminescent nanoparticles in lysosomal-like medium

Cyrille Richard , Florence Gazeau , Nathalie Mignet , Daniel Scherman , Damien Alloyeau
Nanoscale, 2019, ⟨10.1039/C9NR06867H⟩
Journal articles hal-02415118v1
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Conception of nanosized hybrid liposome/poloxamer particles to thicken the interior core of liposomes and delay hydrophilic drug delivery

Shayan Ahmed , Yohann Corvis , Rabah Gahoual , Arlen Euan , Rene Lai-Kuen
International Journal of Pharmaceutics, 2019, 567, ⟨10.1016/j.ijpharm.2019.118488⟩
Journal articles hal-03290600v1
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Qualitative and quantitative analysis of the uptake of lipoplexes by villous placenta explants

Khair Alhareth , Lucie Valero , Khaled Elhady Mohamed , Louise Fliedel , Caroline Roques
International Journal of Pharmaceutics, 2019
Journal articles hal-03017996v1

Qualitative and quantitative analysis of the uptake of lipoplexes by villous placenta explants

Khair Alhareth , Lucie Valero , Khaled Elhady Mohamed , Louise Fliedel , Caroline Roques
International Journal of Pharmaceutics, 2019
Journal articles hal-04119741v1
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Advances on non-invasive physically triggered nucleic acid delivery from nanocarriers

Hai Doan Do , Brice Martin Couillaud , Bich-Thuy Do , Yohann Corvis , Nathalie Mignet
Advanced Drug Delivery Reviews, 2019, 138, pp.3-17. ⟨10.1016/j.addr.2018.10.006⟩
Journal articles hal-02123133v1
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Imaging and therapeutic applications of persistent luminescence nanomaterials

Jianhua Liu , Thomas Lécuyer , Johanne Seguin , Nathalie Mignet , Daniel Scherman
Advanced Drug Delivery Reviews, 2019, 138, pp.193-210. ⟨10.1016/j.addr.2018.10.015⟩
Journal articles hal-02123130v1
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Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics

Hugo Salmon , Rabah Gahoual , Pascal Houzé , Tayssir Ibrahim , Michel Bessodes
Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 18, pp.21-30. ⟨10.1016/j.nano.2019.02.011⟩
Journal articles hal-02123126v1

Nanomedicine as a potential approach to empower the new strategies for the treatment of preeclampsia

Lucie Valero , Khair Alhareth , Sophie Gil , Edouard Lecarpentier , Vassilis Tsatsaris
Drug Discovery Today Biosilico, 2018, 23 (5), pp.1099-1107. ⟨10.1016/j.drudis.2018.01.048⟩
Journal articles hal-02123145v1
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The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce 3+ surface area concentration

V. Baldim , F. Bedioui , Nathalie Mignet , I. Margaill , Jean-Francois Berret
Nanoscale, 2018, 10 (15), pp.6971-6980. ⟨10.1039/C8NR00325D⟩
Journal articles hal-02342481v1

Assessment of the targeting specificity of a fluorescent albumin conceived as a preclinical agent of the liver function

K. Lemdani , H. Salmon , R. Gahoual , M. Bessodes , D. Scherman
Nanoscale, 2018, 10 (45), pp.21151-21160. ⟨10.1039/c8nr04163f⟩
Journal articles hal-02123131v1
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Novel Perfluorinated Triblock Amphiphilic Copolymers for Lipid-Shelled Microbubble Stabilization

Yohann Corvis , Simona Manta , Caroline Thébault , Olivier Couture , Hélène Dhotel
Langmuir, 2018, 34 (33), pp.9744-9753. ⟨10.1021/acs.langmuir.8b01668⟩
Journal articles hal-02123140v1
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Use of mouse model in pharmacokinetic studies of poorly water soluble drugs: Application to fenofibrate

Badr Bahloul , Fathi Safta , Mohamed Ali Lassoued , Hélène Dhotel , Johanne Seguin
Journal of Drug Delivery Science and Technology, 2018, 43, pp.149 - 153. ⟨10.1016/j.jddst.2017.10.006⟩
Journal articles hal-03078844v1
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Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma

Katia Lemdani , Nathalie Mignet , Vincent Boudy , Johanne Seguin , Edward Oujagir
OncoImmunology, 2018, 8 (3), pp.1550342. ⟨10.1080/2162402X.2018.1550342⟩
Journal articles hal-02123122v1

Liposomes as Gene Delivery Vectors for Human Placental Cells

Lucie Valero , Khair Alhareth , Jenifer Espinoza Romero , Warren Viricel , Jeanne Leblond
Molecules, 2018, 23 (5), pp.1085. ⟨10.3390/molecules23051085⟩
Journal articles hal-04119751v1

In vitro distinction between proinflammatory and antiinflammatory macrophages with gadolinium-liposomes and ultrasmall superparamagnetic iron oxide particles at 3.0T

Wassef Khaled , Joao Piraquive , Benjamin Leporq , Jing Hong Wan , Simon Lambert
Journal of Magnetic Resonance Imaging, 2018, ⟨10.1002/jmri.26331⟩
Journal articles hal-01917473v1
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Liposomes as Gene Delivery Vectors for Human Placental Cells

Lucie Valero , Khair Alhareth , Jenifer Espinoza Romero , Warren Viricel , Jeanne Leblond
Molecules, 2018, 23 (5), pp.1085. ⟨10.3390/molecules23051085⟩
Journal articles hal-02123142v1

One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles

Vu-Long Tran , Vivek Thakare , Fabien Rossetti , Anne Baudouin , Grégory Ramniceanu
Journal of materials chemistry‎ B, 2018, 6 (29), pp.4821 - 4834. ⟨10.1039/c8tb00195b⟩
Journal articles hal-01861704v1
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In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI

Caroline J Thébault , Grégory Ramniceanu , Aude Michel , Claire Beauvineau , Christian Girard
Molecular Imaging and Biology, 2018, 21 (2), pp.269-278. ⟨10.1007/s11307-018-1238-3⟩
Journal articles hal-01873316v1

Liposomes as Gene Delivery Vectors for Human Placental Cells

Lucie Valero , Khair Alhareth , Jenifer Espinoza Romero , Warren Viricel , Jeanne Leblond
Molecules, 2018, 23 (5), pp.1085. ⟨10.3390/molecules23051085⟩
Journal articles hal-03806287v1
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Cationic gas-filled microbubbles for ultrasound-based nucleic acids delivery

Anthony Delalande , Colette Bastié , Lucie Pigeon , Simona Manta , Matthias Lebertre
Bioscience Reports, 2017, 37 (6), pp.BSR20160619. ⟨10.1042/BSR20160619⟩
Journal articles hal-02123147v1

Photo-stimulation of persistent luminescence nanoparticles enhances cancer cells death

Gonzalo Ramirez-Garcia , Minerva Martinez-Alfaro , Fanny d'Orlye , Fethi Bedioui , Nathalie Mignet
International Journal of Pharmaceutics, 2017, 532 (2), pp.696-703. ⟨10.1016/j.ijpharm.2017.07.009⟩
Journal articles hal-03290589v1

Electrokinetic Hummel-Dreyer characterization of nanoparticle-plasma protein corona: The non-specific interactions between PEG-modified persistent luminescence nanoparticles and albumin

Gonzalo Ramirez-Garcia , Fanny d'Orlye , Silvia Gutierrez-Granados , Minerva Martinez-Alfaro , Nathalie Mignet
Colloids and Surfaces B: Biointerfaces, 2017, 159, pp.437-444. ⟨10.1016/j.colsurfb.2017.08.012⟩
Journal articles hal-03290592v1

Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo human models: the dually perfused placenta and the suspended villous explants

Lucie Valero , Khair Alhareth , Sophie Gil , Christelle Simasotchi , Caroline Roques
International Journal of Pharmaceutics, 2017, 532 (2), pp.729-737. ⟨10.1016/j.ijpharm.2017.07.076⟩
Journal articles hal-04119770v1

Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice

Gonzalo Ramirez-Garcia , Silvia Gutierrez-Granados , Marco A. Gallegos-Corona , Lourdes Palma-Tirado , Fanny d'Orlye
International Journal of Pharmaceutics, 2017, 532 (2), pp.686-695. ⟨10.1016/j.ijpharm.2017.07.015⟩
Journal articles hal-03290595v1

Electrokinetic Hummel-Dreyer characterization of nanoparticle-plasma protein corona: The non-specific interactions between PEG-modified persistent luminescence nanoparticles and albumin

Gonzalo Ramírez-García , Fanny D’orlyé , Silvia Gutiérrez-Granados , Minerva Martínez-Alfaro , Nathalie Mignet
Colloids and Surfaces B: Biointerfaces, 2017, 159, pp.437-444. ⟨10.1016/j.colsurfb.2017.08.012⟩
Journal articles hal-03897152v1

Photo-stimulation of persistent luminescence nanoparticles enhances cancer cells death

Gonzalo Ramírez-García , Minerva Martínez-Alfaro , Fanny D’orlyé , Fethi Bedioui , Nathalie Mignet
International Journal of Pharmaceutics, 2017, 532 (2), pp.696-703. ⟨10.1016/j.ijpharm.2017.07.009⟩
Journal articles hal-03897145v1

Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice

Gonzalo Ramírez-García , Silvia Gutiérrez-Granados , Marco Gallegos-Corona , Lourdes Palma-Tirado , Fanny D’orlyé
International Journal of Pharmaceutics, 2017, 532 (2), pp.686-695. ⟨10.1016/j.ijpharm.2017.07.015⟩
Journal articles hal-03897149v1
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EVALUATION OF ANTIVASCULAR COMBRETASTATIN A4P EFFICACY BY USING SUPERSONIC SHEAR IMAGING TECHNIQUE OF ECTOPIC COLON CARCINOMA CT26

Johanne Seguin , Nathalie Mignet , Heldmuth Latorre Ossa , Mickaël Tanter , Jean-Luc Gennisson
Ultrasound Med Biol, 2017, 43 (10), pp.2352-2361
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Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery

Ni Zeng , Johanne Seguin , Pierre-Louis Destruel , Gilles Dumortier , Marc Maury
International Journal of Pharmaceutics, 2017, 534 (1-2), pp.128-135. ⟨10.1016/j.ijpharm.2017.09.073⟩
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Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound–mediated transgene expression in liver

Simona Manta , Gilles Renault , Anthony Delalande , Olivier Couture , Isabelle Lagoutte
Journal of Controlled Release, 2017, 262, pp.170 - 181. ⟨10.1016/j.jconrel.2017.07.015⟩
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Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo human models: the dually perfused placenta and the suspended villous explants

Lucie Valero , Khair Alhareth , Sophie Gil , Christelle Simasotchi , Caroline Roques
International Journal of Pharmaceutics, 2017, 532 (2), pp.729-737. ⟨10.1016/j.ijpharm.2017.07.076⟩
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Evaluation of Antivascular Combretastatin A4 P Efficacy Using Supersonic Shear Imaging Technique of Ectopic Colon Carcinoma CT26

Johanne Seguin , Nathalie Mignet , Heldmuth Latorre Ossa , Mickaël Tanter , Jean-Luc Gennisson
Ultrasound in Medicine & Biology, 2017, 43 (10), pp.2352-2361. ⟨10.1016/j.ultrasmedbio.2017.05.013⟩
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Chemically engineered persistent luminescence nanoprobes for bioimaging

Thomas Lécuyer , Eliott Teston , Gonzalo Ramirez-Garcia , Thomas Maldiney , Bruno Viana
Theranostics, 2016, 6 (13), pp.2488-2523. ⟨10.7150/thno.16589⟩
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Characterization of Positively Charged Lipid Shell Microbubbles with Tunable Resistive Pulse Sensing (TRPS) Method: A Technical Note

Simona Manta , Anthony Delalande , Michel Bessodes , Michel Francis Bureau , Daniel Scherman
Ultrasound in Medicine & Biology, 2016, 42 (2), pp.624 - 630. ⟨10.1016/j.ultrasmedbio.2015.10.010⟩
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Metabolism of Flavone-8-acetic Acid in Mice

Minh Hien Pham , Nicolas Auzeil , Anne Regazzetti , Daniel Scherman , Johanne Seguin
Anticancer Research, 2016, 36 (8), pp.3889-3898
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Delayed hepatic uptake of multi-phosphonic acid poly(ethylene glycol) coated iron oxide measured by real-time magnetic resonance imaging

G. Ramniceanu , B.-T. Doan , C. Vezignol , A. Graillot , C. Loubat
RSC Advances, 2016, 6 (68), pp.63788-63800. ⟨10.1039/C6RA09896G⟩
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Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis

Gonzalo Ramírez-García , Fanny d'Orlyé , Silvia Gutiérrez-Granados , Minerva Martínez-Alfaro , Nathalie Mignet
Colloids and Surfaces B: Biointerfaces, 2015, 136, pp.272-281. ⟨10.1016/j.colsurfb.2015.09.022⟩
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Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis

Gonzalo Ramirez-Garcia , Fanny d'Orlye , Silvia Gutierrez-Granados , Minerva Martinez-Alfaro , Nathalie Mignet
Colloids and Surfaces B: Biointerfaces, 2015, 136, pp.272-281. ⟨10.1016/j.colsurfb.2015.09.022⟩
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Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line

Ni Zeng , Nathalie Mignet , Gilles Dumortier , Elodie Olivier , Johanne Seguin
International Journal of Pharmaceutics, 2015, 495 (2), pp.1028-1037. ⟨10.1016/j.ijpharm.2015.09.045⟩
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Self-emulsifying drug delivery system developed by the HLB-RSM approach: Characterization by transmission electron microscopy and pharmacokinetic study

Johanne Seguin , Helene Dhotel , Nathalie Mignet , Badr Bahloul , Mohamed Ali Lassoued
International Journal of Pharmaceutics, 2015, 487 (1-2), pp.56-63. ⟨10.1016/j.ijpharm.2015.04.018⟩
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Preparation and Evaluation of Multiple Nanoemulsions Containing Gadolinium (III) Chelate as a Potential Magnetic Resonance Imaging (MRI) Contrast Agent

Estelle Sigward , Yohann Corvis , Bich-Thuy Doan , Kadri Kindsiko , Johanne Seguin
Pharmaceutical Research, 2015, 32 (9), pp.2983-2994. ⟨10.1007/s11095-015-1680-8⟩
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Fine tuning of mixed ionic and hydrogen bond interactions for plasmid delivery using lipoplexes

Johanne Seguin , Helene Dhotel , Rene Kai-Luen , Michel Bessodes , Nathalie Mignet
European Journal of Pharmaceutics and Biopharmaceutics, 2015, 90, pp.63-69. ⟨10.1016/j.ejpb.2014.11.001⟩
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Influence of additives on a thermosensitive hydrogel for buccal delivery of salbutamol: Relation between micellization, gelation, mechanic and release properties

Ni Zeng , Gilles Dumortier , Marc Maury , Nathalie Mignet , Vincent Boudy
International Journal of Pharmaceutics, 2014, 467 (1-2), pp.70-83. ⟨10.1016/j.ijpharm.2014.03.055⟩
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NF-kappa B related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer

S. Mahindhoratep , H. Ait Bouda , Nelly El Shafey , D. Scherman , A. Kichler
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (11), pp.3257-3263. ⟨10.1016/j.bbagen.2014.06.013⟩
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Quantification of Nitric Oxide Produced By Breast Cancer Cells Stimulated By Persistent Luminescent Nanoparticles: A Study of Nanotoxicity Mechanism

Gonzalo Ramírez García , Silvia Gutierrez Granados , Minerva Martinez Alfaro , Anne Varenne , Fanny Dxorlye
ECS Meeting Abstracts, 2014, MA2014-02 (22), pp.1330-1330. ⟨10.1149/MA2014-02/22/1330⟩
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NF-kB related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer.

S Mahindhoratep , H Ait Bouda , Nelly El Shafey , D Scherman , A Kichler
BBA - Biochimica et Biophysica Acta, 2014, 1840 (11), pp.3257-3263
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Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions

Estelle Sigward , Nathalie Mignet , Patrice Rat , Melody Dutot , Saleh Muhamed
International Journal of Nanomedicine, 2013, 8, pp.611 - 625. ⟨10.2147/IJN.S35661⟩
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Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges

Anthony Delalande , Michiel Postema , Nathalie Mignet , Patrick Midoux , Chantal Pichon
Therapeutic Delivery, 2012, 3 (10), pp.1199-1215. ⟨10.4155/TDE.12.100⟩
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Investigating relationship between transfection and permeabilization by the electric field and/or the Pluronic® L64 in vitro and in vivo.

Michel Francis Bureau , Luc Wasungu , Lauriane Jugé , Daniel Scherman , Marie-Pierre Rols
The Journal of Gene Medicine, 2012, 14 (3), pp.204-15. ⟨10.1002/jgm.2610⟩
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Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges.

Anthony Delalande , Michiel Postema , Nathalie Mignet , Patrick Midoux , Chantal Pichon
Ther Deliv, 2012, 3 (10), pp.1199-1215
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Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours.

Johanne Seguin , Céline Nicolazzi , Nathalie Mignet , Daniel Scherman , Guy G. Chabot
Tumor Biology, 2012, 33 (5), pp.1709-17. ⟨10.1007/s13277-012-0428-x⟩
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Protonation of lipids impacts the supramolecular and biological properties of their self-assembly.

Marie Breton , Jean-François Berret , Claudie Bourgaux , Teresa Kral , Martin Hof
Langmuir, 2011, 27 (20), pp.12336-45. ⟨10.1021/la202439s⟩
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Lipothioureas as Lipids for Gene Transfection: A Review

Marie Breton , Jeanne Leblond , Isabelle Tranchant , Daniel Scherman , Michel Bessodes
Pharmaceuticals, 2011, 4 (10), pp.1381-1399. ⟨10.3390/ph4101381⟩
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Synthesis and Application of Lactosylated, 99m Tc Chelating Albumin for Measurement of Liver Function

Philippe Chaumet-Riffaud , Ivan Martinez-Duncker , Anne-Laure Marty , Cyrille Richard , Alain Prigent
Bioconjugate Chemistry, 2010, 21 (4), pp.589-596. ⟨10.1021/bc900275f⟩
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Interactions between sub-10-nm iron and cerium oxide nanoparticles and 3T3 fibroblasts: the role of the coating and aggregation state

Malak Safi , Hiba Sarrouj , Olivier Sandre , Nathalie Mignet , Jean-François Berret
Nanotechnology, 2010, 21, pp.145103. ⟨10.1088/0957-4484/21/14/145103⟩
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Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly

Marie Breton , Michel Bessodes , Serge Bouaziz , Jean Herscovici , Daniel Scherman
Biophysical Chemistry, 2009, 145 (1), pp.7-16. ⟨10.1016/j.bpc.2009.08.003⟩
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Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly

Marie Breton , Michel Bessodes , Serge Bouaziz , Jean Herscovici , Daniel Scherman
Biophysical Chemistry, 2009, 145 (1), pp.7. ⟨10.1016/j.bpc.2009.08.003⟩
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Functionalization of single- and multi-walled carbon nanotubes with cationic amphiphiles for plasmid DNA complexation and transfection

Cyrille Richard , Nathalie Mignet , Céline Largeau , Virginie Escriou , Michel Bessodes
Nano Research, 2009, 2 (8), pp.638-647. ⟨10.1007/s12274-009-9066-z⟩
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Comparative gene transfer between cationic and thiourea lipoplexes

Marie Breton , Jeanne Leblond , Johanne Seguin , Patrick Midoux , Daniel Scherman
The Journal of Gene Medicine, 2009, 12 (1), pp.45-54. ⟨10.1002/jgm.1417⟩
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Amphiphilic perfluoroalkyl carbohydrates as new tools for liver imaging

C. Richard , P. Chaumet-Riffaud , A. Belland , A. Parat , C. Contino-Pepin
International Journal of Pharmaceutics, 2009, 379 (2), pp.301-308. ⟨10.1016/j.ijpharm.2009.05.045⟩
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Lipopolythiourea Transfecting Agents: Lysine Thiourea Derivatives

Jeanne Leblond , Nathalie Mignet , Celine Largeau , Johanne Seguin , Daniel Scherman
Bioconjugate Chemistry, 2007, ⟨10.1021/bc7001924⟩
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Design, Synthesis, and Evaluation of Enhanced DNA Binding New Lipopolythioureas

Jeanne Leblond , Nathalie Mignet , Lucie Leseurre , Celine Largeau , Michel Bessodes
Bioconjugate Chemistry, inPress, ⟨10.1021/bc060110g⟩
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Liposome biodistribution by time resolved fluorimetry of lipophilic europium complexes

Nathalie Mignet , Le Masne de Chermont Quentin , Randrianarivelo Tatiana , Seguin Johanne , Richard Cyrille
European Biophysics Journal, 2006, 35 (2), pp.155-161
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Design, synthesis, and evaluation of enhanced DNA binding new lipopolythioureas.

Jeanne Leblond , Nathalie Mignet , Lucie Leseurre , Céline Largeau , Michel Bessodes
Bioconjugate Chemistry, 2006, 17 (5), pp.1200-8. ⟨10.1021/bc060110g⟩
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Sparse non-negative matrix factorization for preclinical bioluminescent imaging

Erwan Dereure , Christophe Kervazo , Seguin Johanne , Anikitos Garofalakis , Elsa Angelini
IEEE International Symposium on Biomedical Imaging (ISBI), Apr 2023, Cartagena, Colombia
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Factorisation Non-Négative de Matrice pour séparation de sources en Imagerie par Bioluminescence préclinique

Erwan Dereure , Elsa Angelini , Anikitos Garofalakis , Johanne Seguin , Nathalie Mignet
GRETSI '22 : XXVIIIème Colloque Francophone de Traitement du Signal et des Images, Sep 2022, Nancy, France
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Phosphonate PEG Copolymers to control the USPIO stealthiness

Gregory Ramniceanu , Bich-Thuy Doan , Camille Vezignol , Alain Graillot , Quentin Crouzet
Journées RITS 2015, Mar 2015, Dourdan, France. p20-21
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Positively charged microbubbles to target nucleic acid delivery with ultrasound

Simona Manta , Anthony Delalande , Gilles Renault , Michel Francis Bureau , Matthias Lebertre
Journées RITS 2015, Mar 2015, Dourdan, France
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Multimodal RM and Optic Imaging using ultramagnetic liposomes to monitor a cancer therapy

Caroline J Thébault , Grégory Ramniceanu , Johanne Seguin , Aude Michel , Claire Beauvineau
Journées RITS 2015, Mar 2015, Dourdan, France. p16-17 Section nanomédecine
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Distinction between pro and anti-inflammatory macrophages using MRI relaxometry and quantitative susceptibility mapping

Wassef Khaled , Benjamin Leporq , J.H Wan , Philippe Garteiser , Simon A. Lambert
23th International Society of Magnetic Resonance in Medicine annual meeting, May 2015, Toronto, Canada
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Grading cancer from liver histology images using inter and intra region spatial relations

Mickaël Garnier , Maya Alsheh Ali , Johanne Seguin , Nathalie Mignet , Thomas Hurtut
International Conference on Image Analysis and Recognition, Oct 2014, Portugal. pp.247-254
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Comparison of the Spatial Organization in Colorectal Tumors using Second-Order Statistics and Functional ANOVA

Maya Alsheh Ali , Johanne Seguin , Aurélie Fisher , Nathalie Mignet , Laurent Wendling
Image and Signal Processing and Analysis (ISPA), 2013 8th International Symposium on, 2013, Italy. pp.257 - 261, ⟨10.1109/ISPA.2013.6703749⟩
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Comparison of the Spatial Organization in Colorectal Tumors using Second-Order Statistics and Functional ANOVA

M. Alsheh Ali , J. Seguin , A. Fischer , Nathalie Mignet , L. Wendling
Image and Signal Processing and Analysis (ISPA), 2013 8th International Symposium on, 2013, Trieste, Italy. pp.257-261, ⟨10.1109/ISPA.2013.6703749⟩
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