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Curriculum Vitae of Dr Nathalie MIGNET, PhD


 

CNRS Research Director

 

National Scientific Research Center (CNRS) - France.

 

Born 01/10/1970

 

 

 

•Leader of the laboratory: UTCBS: Unité des Technologies Chimiques et Biologiques pour la Santé

Team Leader  of the team Vector for Molecular Imaging and targeted therapy in UTCBS

Université de Paris - UMR 8258 - CNRS – UMR-S 1267 Inserm

 

 

 

 

 

Main scientific field and domain of competence:

 

 

 

Diplomas

 

 

 

  1. V. Baldim, F. Bedioui, N. Mignet, I. Margaill, J.-F. Berret Ce3+-surface density superposition principle observed for CeO2-x superoxide dismutase and catalase-like catalytic activities Nanoscale 2018, 10(15):6971-6980.

     

 

2.         Zeng N., Seguin J., Dumortier G., Maury M., Bessodes M., Scherman D., Mignet N., Boudy V. Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: in vitro and in vivo validation of a sustained buccal drug delivery Int J Pharm 2017, 534(1-2):128-135.

 

 

 

3.         Ramírez-García G, Gutiérrez-Granados S, Gallegos-Corona MA, Palma-Tirado L, d'Orlyé F, Varenne A, Mignet N, Richard C, Martínez-Alfaro M. Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice. Int J Pharm. 2017, 532, 686-695.

 

4 Valero L, Alhareth K, Gil S, Simasotchi C, Roques C, Scherman D, Mignet N, Fournier T, Andrieux K. Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo models: the dually perfused human placenta and the suspended villous explants. Int J Pharm. 2017, 532(2):729-737

 

 

 

5 Manta S, Renault G, Delalande A, Couture O, Lagoutte I, Seguin J, Lager F, Houzé P, Midoux P, Bessodes M, Scherman D, Bureau MF, Marie C, Pichon C, Mignet, N. Cationic Microbubbles and Antibiotic-Free Plasmid for sustained Ultrasound-mediated Transgene Expression in liver. J. Controlled Rel. 2017, 262:170-181

 

 

 

6          Ramírez-García G, d'Orlyé F, Gutiérrez-Granados S, Martínez-Alfaro M, Mignet N, Richard C, Varenne A. Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis. Colloids Surf B Biointerfaces. 2015, 136, 272-281

 

 

 

7.         Zeng N., Mignet N, Dumortier G, Olivier E, Seguin J, Maury M, Scherman D, Rat P, Boudy V.Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line International Journal of Pharmaceutics, Int J. Pharm. 2015, 495, 1028-37.

 

 

 

8.         Seguin J, Dhotel H, Kai-Luen R, Bessodes M, Mignet N. Fine tuning of mixed ionic and hydrogen bond interactions for plasmid delivery using lipoplexes. Eur J Pharm Biopharm. 2015, 90, 63-9.

 

 

 

9.         M. Breton, J.F. Berret, C. Bourgaux, T. Kral, M. Hof, C. Pichon, M. Bessodes, D. Scherman, N. Mignet, Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly. Langmuir, 2011, 27, 12336-45

 

 

 

10.       G. Pembouong, N. Morellet, T. Kral, M. Hof, D. Scherman, M-F. Bureau, N. Mignet, Triblock copolymer L64 destabilizes lipidic membranes and does not interact with DNA J. Controlled Release, 2011, 151, 57-64

 

 

 

 

 


Journal articles79 documents

  • Thomas Lécuyer, Johanne Seguin, Alice Balfourier, Marine Delagrange, Pierre Burckel, et al.. Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up. Nanoscale, 2022, ⟨10.1039/d2nr03546d⟩. ⟨hal-03827771⟩
  • Marinella Difonzo, Louise Fliedel, Nathalie Mignet, Khair Alhareth, Karine Andrieux. How Could Nanomedicine Improve the Safety of Contrast Agents for MRI during Pregnancy?. Sci, 2022, 4 (1), pp.11. ⟨10.3390/sci4010011⟩. ⟨hal-03712176⟩
  • Gabriel Alviset, Yohann Corvis, Karim Hammad, Josiane Lemut, Marc Maury, et al.. New Preservative-Free Formulation for the Enhanced Ocular Bioavailability of Prostaglandin Analogues in Glaucoma. Pharmaceutics, 2022, 14 (2), pp.453. ⟨10.3390/pharmaceutics14020453⟩. ⟨hal-03705031⟩
  • Thomas Lécuyer, Nicolas Bia, Pierre Burckel, Cédric Loubat, Alain Graillot, et al.. Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour. Nanoscale, 2022, ⟨10.1039/D1NR07114A⟩. ⟨hal-03528462⟩
  • Thomas Lécuyer, Nicolas Bia, Pierre Burckel, Cédric Loubat, Alain Graillot, et al.. Persistent luminescence nanoparticles functionalized by polymers bearing phosphonic acid anchors: synthesis, characterization, and in vivo behaviour. Nanoscale, 2022, 14 (4), pp.1386-1394. ⟨10.1039/d1nr07114a⟩. ⟨hal-03872183⟩
  • Thomas Lécuyer, Johanne Seguin, Alice Balfourier, Marine Delagrange, Pierre Burckel, et al.. Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up. Nanoscale, In press, ⟨10.1039/d2nr03546d⟩. ⟨hal-03828116⟩
  • Louise Fliedel, Khair Alhareth, Nathalie Mignet, Thierry Fournier, Karine Andrieux. Placental Models for Evaluation of Nanocarriers as Drug Delivery Systems for Pregnancy Associated Disorders. Biomedicines, 2022, 10 (5), pp.936. ⟨10.3390/biomedicines10050936⟩. ⟨hal-03712174⟩
  • Louise Fliedel, Khair Alhareth, Johanne Seguin, Marwa El-Khashab, Audrey Chissey, et al.. Influence of Liposomes’ and Lipoplexes’ Physicochemical Characteristics on Their Uptake Rate and Mechanisms by the Placenta. International Journal of Molecular Sciences, 2022, 23 (11), pp.6299. ⟨10.3390/ijms23116299⟩. ⟨hal-03712180⟩
  • Thomas Lécuyer, Johanne Seguin, Alice Balfourier, Marine Delagrange, Pierre Burckel, et al.. Fate and biological impact of persistent luminescence nanoparticles after injection in mice: a one-year follow-up. Nanoscale, 2022, 14 (42), pp.15760-15771. ⟨10.1039/d2nr03546d⟩. ⟨hal-03872190⟩
  • Geoffroy Goujon, Victor Baldim, Caroline Roques, Nicolas Bia, Johanne Seguin, et al.. Antioxidant activity and toxicity study of cerium oxide nanoparticles stabilized with innovative functional copolymers. Advanced Healthcare Materials, 2021, 10 (11), pp.2100059. ⟨10.1002/adhm.202100059⟩. ⟨hal-03452741⟩
  • Morgane Renault-Mahieux, Victoire Vieillard, Johanne Seguin, Philippe Espeau, Dang Tri Le, et al.. Co-Encapsulation of Fisetin and Cisplatin into Liposomes for Glioma Therapy: From Formulation to Cell Evaluation. Pharmaceutics, 2021, 13, ⟨10.3390/pharmaceutics13070970⟩. ⟨hal-03423934⟩
  • Shayan Ahmed, Hugo Salmon, Nicholas Distasio, Hai Doan Do, Daniel Scherman, et al.. Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged. Pharmaceutics, 2021, 13 (4), ⟨10.3390/pharmaceutics13040479⟩. ⟨hal-03290555⟩
  • Mahdi Ftouh, Nesrine Kalboussi, Nabil Abid, Souad Sfar, Nathalie Mignet, et al.. Contribution of Nanotechnologies to Vaccine Development and Drug Delivery against Respiratory Viruses. PPAR Research, 2021, 2021, pp.1-28. ⟨10.1155/2021/6741290⟩. ⟨hal-03423555⟩
  • Petronille Roy, Nathalie Mignet, Marc Pocard, Vincent Boudy. Drug delivery systems to prevent peritoneal metastasis after surgery of digestives or ovarian carcinoma: A review. International Journal of Pharmaceutics, 2021, 592, ⟨10.1016/j.ijpharm.2020.120041⟩. ⟨hal-03290554⟩
  • Johanne Seguin, Cynthia Pimpie, Petronille Roy, Chantal Al Sabbagh, Marc Pocard, et al.. Combination of tumor cell anti-adhesion and anti-tumor effect to prevent recurrence after cytoreductive surgery in a mice model. European Journal of Pharmaceutics and Biopharmaceutics, 2021, 169, pp.37-43. ⟨10.1016/j.ejpb.2021.01.020⟩. ⟨hal-03290586⟩
  • Gonzalo Ramírez García, Fanny d'Orlyé, Cyrille Richard, Nathalie Mignet, Anne Varenne. Electrokinetic elucidation of the interactions between persistent luminescent nanoprobes and the binary apolipoprotein-E/albumin protein system. Analyst, 2021, 146 (17), pp.5245-5254. ⟨10.1039/d1an00781e⟩. ⟨hal-03482252⟩
  • Chantal Al Sabbagh, Johanne Seguin, Elena Agapova, Dounia Kramerich, Vincent Boudy, et al.. Thermosensitive hydrogels for local delivery of 5-fluorouracil as neoadjuvant or adjuvant therapy in colorectal cancer. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 157, pp.154-164. ⟨10.1016/j.ejpb.2020.10.011⟩. ⟨hal-03290582⟩
  • Caroline J Thébault, Grégory Ramniceanu, Sarah Boumati, Aude Michel, Johanne Seguin, et al.. Theranostic MRI liposomes for magnetic targeting and ultrasound triggered release of the antivascular CA4P. Journal of Controlled Release, 2020, 322, pp.137-148. ⟨10.1016/j.jconrel.2020.03.003⟩. ⟨hal-03059422⟩
  • Pierre-Louis Destruel, Ni Zeng, Johanne Seguin, Sophie Douat, Frederic Rosa, et al.. Novel in situ gelling ophthalmic drug delivery system based on gellan gum and hydroxyethylcellulose: Innovative rheological characterization, in vitro and in vivo evidence of a sustained precorneal retention time. International Journal of Pharmaceutics, 2020, 574, pp.118734. ⟨10.1016/j.ijpharm.2019.118734⟩. ⟨hal-03290593⟩
  • Pierre-Louis Destruel, Ni Zeng, Françoise Brignole-Baudouin, Sophie Douat, Johanne Seguin, et al.. In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics. Pharmaceutics, 2020, 12 (4), pp.360. ⟨10.3390/pharmaceutics12040360⟩. ⟨hal-02798293⟩
  • Elise Lepeltier, Vincent Levet, Tu Lee, Nathalie Mignet, Jianliang Shen, et al.. Editorial: Supramolecular Nanomaterials for Engineering, Drug Delivery, and Medical Applications. Frontiers in Chemistry, 2020, 8, pp.626468. ⟨10.3389/fchem.2020.626468⟩. ⟨hal-03050105⟩
  • Jianhua Liu, Lenka Kotrchová, Thomas Lécuyer, Yohann Corvis, Johanne Seguin, et al.. Coating Persistent Luminescence Nanoparticles With Hydrophilic Polymers for in vivo Imaging. Frontiers in Chemistry, 2020, 8, pp.584114. ⟨10.3389/fchem.2020.584114⟩. ⟨hal-03084996⟩
  • Rabah Gahoual, Gérard Bolbach, Ikram Ould-Melha, Gilles Clodic, Yannis Francois, et al.. Kinetic and structural characterization of therapeutic albumin chemical functionalization using complementary mass spectrometry techniques. Journal of Pharmaceutical and Biomedical Analysis, 2020, 185, pp.113242. ⟨10.1016/j.jpba.2020.113242⟩. ⟨hal-03022806⟩
  • Hai Doan Do, Hai Doan Do, Christine Ménager, Aude Michel, Johanne Seguin, et al.. Development of Theranostic Cationic Liposomes Designed for Image-Guided Delivery of Nucleic Acid. Pharmaceutics, 2020, 12 (9), pp.854. ⟨10.3390/pharmaceutics12090854⟩. ⟨hal-03059436⟩
  • Shayan Ahmed, Khair Alhareth, Nathalie Mignet. Advancement in nanogel formulations provides controlled drug release. International Journal of Pharmaceutics, 2020, 584, pp.119435 -. ⟨10.1016/j.ijpharm.2020.119435⟩. ⟨hal-03490686⟩
  • Pauline Legrand, Rabah Gahoual, Raphael Benattar, Balthazar Toussaint, Caroline Roques, et al.. Comprehensive and quantitative stability study of ascorbic acid using capillary zone electrophoresis with ultraviolet detection and high-resolution tandem mass spectrometry. Journal of Separation Science, 2020, 43 (14), pp.2925-2935. ⟨10.1002/jssc.202000389⟩. ⟨hal-03289975⟩
  • Khair Alhareth, Lucie Valero, Khaled Elhady Mohamed, Louise Fliedel, Caroline Roques, et al.. Qualitative and quantitative analysis of the uptake of lipoplexes by villous placenta explants. International Journal of Pharmaceutics, 2019. ⟨hal-03017996⟩
  • François Lux, Vu Long Tran, Eloise Thomas, Sandrine Dufort, Fabien Rossetti, et al.. AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. British Journal of Radiology, 2019, 92 (1093), pp.20180365. ⟨10.1259/bjr.20180365⟩. ⟨hal-01935540⟩
  • Brice Martin Couillaud, Philippe Espeau, Nathalie Mignet, Yohann Corvis. State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation. ChemMedChem, 2019, 14 (1), pp.8-23. ⟨10.1002/cmdc.201800612⟩. ⟨hal-02123129⟩
  • Shayan Ahmed, Yohann Corvis, Rabah Gahoual, Arlen Euan, Rene Lai-Kuen, et al.. Conception of nanosized hybrid liposome/poloxamer particles to thicken the interior core of liposomes and delay hydrophilic drug delivery. International Journal of Pharmaceutics, 2019, 567, ⟨10.1016/j.ijpharm.2019.118488⟩. ⟨hal-03290600⟩
  • Cyrille Richard, Florence Gazeau, Nathalie Mignet, Daniel Scherman, Damien Alloyeau, et al.. Degradation of ZnGa2O4:Cr3+ luminescent nanoparticles in lysosomal-like medium. Nanoscale, 2019, ⟨10.1039/C9NR06867H⟩. ⟨hal-02415118⟩
  • Hai Doan Do, Brice Martin Couillaud, Bich-Thuy Do, Yohann Corvis, Nathalie Mignet. Advances on non-invasive physically triggered nucleic acid delivery from nanocarriers. Advanced Drug Delivery Reviews, 2019, 138, pp.3-17. ⟨10.1016/j.addr.2018.10.006⟩. ⟨hal-02123133⟩
  • Hugo Salmon, Rabah Gahoual, Pascal Houzé, Tayssir Ibrahim, Michel Bessodes, et al.. Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics. Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 18, pp.21-30. ⟨10.1016/j.nano.2019.02.011⟩. ⟨hal-02123126⟩
  • Jianhua Liu, Thomas Lécuyer, Johanne Seguin, Nathalie Mignet, Daniel Scherman, et al.. Imaging and therapeutic applications of persistent luminescence nanomaterials. Advanced Drug Delivery Reviews, 2019, 138, pp.193-210. ⟨10.1016/j.addr.2018.10.015⟩. ⟨hal-02123130⟩
  • Katia Lemdani, Johanne Seguin, Christelle Lesieur, Chantal Al Sabbagh, Bich-Thuy Doan, et al.. Mucoadhesive thermosensitive hydrogel for the intra-tumoral delivery of immunomodulatory agents, in vivo evidence of adhesion by means of non-invasive imaging techniques. International Journal of Pharmaceutics, 2019, 567, pp.118421. ⟨10.1016/j.ijpharm.2019.06.012⟩. ⟨hal-02325457⟩
  • K. Lemdani, H. Salmon, R. Gahoual, M. Bessodes, D. Scherman, et al.. Assessment of the targeting specificity of a fluorescent albumin conceived as a preclinical agent of the liver function. Nanoscale, 2018, 10 (45), pp.21151-21160. ⟨10.1039/c8nr04163f⟩. ⟨hal-02123131⟩
  • Yohann Corvis, Simona Manta, Caroline Thébault, Olivier Couture, Hélène Dhotel, et al.. Novel Perfluorinated Triblock Amphiphilic Copolymers for Lipid-Shelled Microbubble Stabilization. Langmuir, 2018, 34 (33), pp.9744-9753. ⟨10.1021/acs.langmuir.8b01668⟩. ⟨hal-02123140⟩
  • Lucie Valero, Khair Alhareth, Jenifer Espinoza Romero, Warren Viricel, Jeanne Leblond, et al.. Liposomes as Gene Delivery Vectors for Human Placental Cells. Molecules, 2018, 23 (5), pp.1085. ⟨10.3390/molecules23051085⟩. ⟨hal-02123142⟩
  • Vu-Long Tran, Vivek Thakare, Fabien Rossetti, Anne Baudouin, Grégory Ramniceanu, et al.. One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles. Journal of materials chemistry‎ B, 2018, 6 (29), pp.4821 - 4834. ⟨10.1039/c8tb00195b⟩. ⟨hal-01861704⟩
  • Lucie Valero, Khair Alhareth, Sophie Gil, Edouard Lecarpentier, Vassilis Tsatsaris, et al.. Nanomedicine as a potential approach to empower the new strategies for the treatment of preeclampsia. Drug Discovery Today Biosilico, 2018, 23 (5), pp.1099-1107. ⟨10.1016/j.drudis.2018.01.048⟩. ⟨hal-02123145⟩
  • V. Baldim, F. Bedioui, Nathalie Mignet, I. Margaill, Jean-Francois Berret. The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce 3+ surface area concentration. Nanoscale, 2018, 10 (15), pp.6971-6980. ⟨10.1039/C8NR00325D⟩. ⟨hal-02342481⟩
  • Wassef Khaled, Joao Piraquive, Benjamin Leporq, Jing Hong Wan, Simon Lambert, et al.. In vitro distinction between proinflammatory and antiinflammatory macrophages with gadolinium-liposomes and ultrasmall superparamagnetic iron oxide particles at 3.0T. Journal of Magnetic Resonance Imaging, 2018, ⟨10.1002/jmri.26331⟩. ⟨hal-01917473⟩
  • Badr Bahloul, Fathi Safta, Mohamed Ali Lassoued, Hélène Dhotel, Johanne Seguin, et al.. Use of mouse model in pharmacokinetic studies of poorly water soluble drugs: Application to fenofibrate. Journal of Drug Delivery Science and Technology, 2018, 43, pp.149 - 153. ⟨10.1016/j.jddst.2017.10.006⟩. ⟨hal-03078844⟩
  • Katia Lemdani, Nathalie Mignet, Vincent Boudy, Johanne Seguin, Edward Oujagir, et al.. Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma. OncoImmunology, 2018, 8 (3), pp.1550342. ⟨10.1080/2162402X.2018.1550342⟩. ⟨hal-02123122⟩
  • Lucie Valero, Khair Alhareth, Jenifer Espinoza Romero, Warren Viricel, Jeanne Leblond, et al.. Liposomes as Gene Delivery Vectors for Human Placental Cells. Molecules, 2018, 23 (5), pp.1085. ⟨10.3390/molecules23051085⟩. ⟨hal-03806287⟩
  • Caroline J Thébault, Grégory Ramniceanu, Aude Michel, Claire Beauvineau, Christian Girard, et al.. In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI. Molecular Imaging and Biology, 2018, 21 (2), pp.269-278. ⟨10.1007/s11307-018-1238-3⟩. ⟨hal-01873316⟩
  • Ni Zeng, Johanne Seguin, Pierre-Louis Destruel, Gilles Dumortier, Marc Maury, et al.. Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery. International Journal of Pharmaceutics, 2017, 534 (1-2), pp.128-135. ⟨10.1016/j.ijpharm.2017.09.073⟩. ⟨hal-02123148⟩
  • Simona Manta, Gilles Renault, Anthony Delalande, Olivier Couture, Isabelle Lagoutte, et al.. Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound–mediated transgene expression in liver. Journal of Controlled Release, 2017, 262, pp.170 - 181. ⟨10.1016/j.jconrel.2017.07.015⟩. ⟨hal-01656574⟩
  • Gonzalo Ramirez-Garcia, Silvia Gutierrez-Granados, Marco A. Gallegos-Corona, Lourdes Palma-Tirado, Fanny d'Orlye, et al.. Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice. International Journal of Pharmaceutics, 2017, 532 (2), pp.686-695. ⟨10.1016/j.ijpharm.2017.07.015⟩. ⟨hal-03290595⟩
  • Johanne Seguin, Nathalie Mignet, Heldmuth Latorre Ossa, Mickaël Tanter, Jean-Luc Gennisson. EVALUATION OF ANTIVASCULAR COMBRETASTATIN A4P EFFICACY BY USING SUPERSONIC SHEAR IMAGING TECHNIQUE OF ECTOPIC COLON CARCINOMA CT26. Ultrasound Med Biol, 2017, 43 (10), pp.2352-2361. ⟨hal-03191947⟩
  • Lucie Valero, Khair Alhareth, Sophie Gil, Christelle Simasotchi, Caroline Roques, et al.. Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo human models: the dually perfused placenta and the suspended villous explants. International Journal of Pharmaceutics, 2017, 532 (2), pp.729-737. ⟨10.1016/j.ijpharm.2017.07.076⟩. ⟨hal-02319716⟩
  • Gonzalo Ramirez-Garcia, Minerva Martinez-Alfaro, Fanny d'Orlye, Fethi Bedioui, Nathalie Mignet, et al.. Photo-stimulation of persistent luminescence nanoparticles enhances cancer cells death. International Journal of Pharmaceutics, 2017, 532 (2), pp.696-703. ⟨10.1016/j.ijpharm.2017.07.009⟩. ⟨hal-03290589⟩
  • Gonzalo Ramirez-Garcia, Fanny d'Orlye, Silvia Gutierrez-Granados, Minerva Martinez-Alfaro, Nathalie Mignet, et al.. Electrokinetic Hummel-Dreyer characterization of nanoparticle-plasma protein corona: The non-specific interactions between PEG-modified persistent luminescence nanoparticles and albumin. Colloids and Surfaces B: Biointerfaces, 2017, 159, pp.437-444. ⟨10.1016/j.colsurfb.2017.08.012⟩. ⟨hal-03290592⟩
  • Anthony Delalande, Colette Bastié, Lucie Pigeon, Simona Manta, Matthias Lebertre, et al.. Cationic gas-filled microbubbles for ultrasound-based nucleic acids delivery. Bioscience Reports, 2017, 37 (6), pp.BSR20160619. ⟨10.1042/BSR20160619⟩. ⟨hal-02123147⟩
  • Simona Manta, Anthony Delalande, Michel Bessodes, Michel Francis Bureau, Daniel Scherman, et al.. Characterization of Positively Charged Lipid Shell Microbubbles with Tunable Resistive Pulse Sensing (TRPS) Method: A Technical Note. Ultrasound in Medicine & Biology, 2016, 42 (2), pp.624 - 630. ⟨10.1016/j.ultrasmedbio.2015.10.010⟩. ⟨hal-01407496⟩
  • Minh Hien Pham, Nicolas Auzeil, Anne Regazzetti, Daniel Scherman, Johanne Seguin, et al.. Metabolism of Flavone-8-acetic Acid in Mice. Anticancer Research, 2016, 36 (8), pp.3889-3898. ⟨hal-03290548⟩
  • G. Ramniceanu, B.-T. Doan, C. Vezignol, A. Graillot, C. Loubat, et al.. Delayed hepatic uptake of multi-phosphonic acid poly(ethylene glycol) coated iron oxide measured by real-time magnetic resonance imaging. RSC Advances, 2016, 6 (68), pp.63788-63800. ⟨10.1039/C6RA09896G⟩. ⟨hal-02342501⟩
  • Ni Zeng, Nathalie Mignet, Gilles Dumortier, Elodie Olivier, Johanne Seguin, et al.. Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line. International Journal of Pharmaceutics, 2015, 495 (2), pp.1028-1037. ⟨10.1016/j.ijpharm.2015.09.045⟩. ⟨hal-03290547⟩
  • Gonzalo Ramirez-Garcia, Fanny d'Orlye, Silvia Gutierrez-Granados, Minerva Martinez-Alfaro, Nathalie Mignet, et al.. Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis. Colloids and Surfaces B: Biointerfaces, 2015, 136, pp.272-281. ⟨10.1016/j.colsurfb.2015.09.022⟩. ⟨hal-03290598⟩
  • Johanne Seguin, Helene Dhotel, Nathalie Mignet, Badr Bahloul, Mohamed Ali Lassoued, et al.. Self-emulsifying drug delivery system developed by the HLB-RSM approach: Characterization by transmission electron microscopy and pharmacokinetic study. International Journal of Pharmaceutics, 2015, 487 (1-2), pp.56-63. ⟨10.1016/j.ijpharm.2015.04.018⟩. ⟨hal-03290584⟩
  • Estelle Sigward, Yohann Corvis, Bich-Thuy Doan, Kadri Kindsiko, Johanne Seguin, et al.. Preparation and Evaluation of Multiple Nanoemulsions Containing Gadolinium (III) Chelate as a Potential Magnetic Resonance Imaging (MRI) Contrast Agent. Pharmaceutical Research, 2015, 32 (9), pp.2983-2994. ⟨10.1007/s11095-015-1680-8⟩. ⟨hal-03290599⟩
  • Johanne Seguin, Helene Dhotel, Rene Kai-Luen, Michel Bessodes, Nathalie Mignet. Fine tuning of mixed ionic and hydrogen bond interactions for plasmid delivery using lipoplexes. European Journal of Pharmaceutics and Biopharmaceutics, 2015, 90, pp.63-69. ⟨10.1016/j.ejpb.2014.11.001⟩. ⟨hal-03290551⟩
  • S Mahindhoratep, H Ait Bouda, Nelly El Shafey, D Scherman, A Kichler, et al.. NF-kB related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer.. BBA - Biochimica et Biophysica Acta, 2014, 1840 (11), pp.3257-3263. ⟨hal-01179311⟩
  • Ni Zeng, Gilles Dumortier, Marc Maury, Nathalie Mignet, Vincent Boudy. Influence of additives on a thermosensitive hydrogel for buccal delivery of salbutamol: Relation between micellization, gelation, mechanic and release properties. International Journal of Pharmaceutics, 2014, 467 (1-2), pp.70-83. ⟨10.1016/j.ijpharm.2014.03.055⟩. ⟨hal-03290560⟩
  • Estelle Sigward, Nathalie Mignet, Patrice Rat, Melody Dutot, Saleh Muhamed, et al.. Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions. International Journal of Nanomedicine, 2013, 8, pp.611 - 625. ⟨10.2147/IJN.S35661⟩. ⟨hal-01583935⟩
  • Michel Francis Bureau, Luc Wasungu, Lauriane Jugé, Daniel Scherman, Marie-Pierre Rols, et al.. Investigating relationship between transfection and permeabilization by the electric field and/or the Pluronic® L64 in vitro and in vivo.. The Journal of Gene Medicine, 2012, 14 (3), pp.204-15. ⟨10.1002/jgm.2610⟩. ⟨inserm-00679701⟩
  • Johanne Seguin, Céline Nicolazzi, Nathalie Mignet, Daniel Scherman, Guy G. Chabot. Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours.. Tumor Biology, 2012, 33 (5), pp.1709-17. ⟨10.1007/s13277-012-0428-x⟩. ⟨inserm-00709732⟩
  • Anthony Delalande, Michiel Postema, Nathalie Mignet, Patrick Midoux, Chantal Pichon. Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges.. Ther Deliv, 2012, 3 (10), pp.1199-1215. ⟨hal-00817350⟩
  • Anthony Delalande, Michiel Postema, Nathalie Mignet, Patrick Midoux, Chantal Pichon. Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges. Therapeutic Delivery, 2012, 3 (10), pp.1199-1215. ⟨10.4155/TDE.12.100⟩. ⟨hal-03193228⟩
  • Marie Breton, Jeanne Leblond, Isabelle Tranchant, Daniel Scherman, Michel Bessodes, et al.. Lipothioureas as Lipids for Gene Transfection: A Review. Pharmaceuticals, 2011, 4 (10), pp.1381-1399. ⟨10.3390/ph4101381⟩. ⟨hal-02512516⟩
  • Marie Breton, Jean-François Berret, Claudie Bourgaux, Teresa Kral, Martin Hof, et al.. Protonation of lipids impacts the supramolecular and biological properties of their self-assembly.. Langmuir, 2011, 27 (20), pp.12336-45. ⟨10.1021/la202439s⟩. ⟨hal-00720543⟩
  • Malak Safi, Hiba Sarrouj, Olivier Sandre, Nathalie Mignet, Jean-François Berret. Interactions between sub-10-nm iron and cerium oxide nanoparticles and 3T3 fibroblasts: the role of the coating and aggregation state. Nanotechnology, 2010, 21, pp.145103. ⟨10.1088/0957-4484/21/14/145103⟩. ⟨hal-00533474⟩
  • Marie Breton, Michel Bessodes, Serge Bouaziz, Jean Herscovici, Daniel Scherman, et al.. Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly. Biophysical Chemistry, 2009, 145 (1), pp.7-16. ⟨10.1016/j.bpc.2009.08.003⟩. ⟨hal-02122492⟩
  • Marie Breton, Michel Bessodes, Serge Bouaziz, Jean Herscovici, Daniel Scherman, et al.. Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly. Biophysical Chemistry, 2009, 145 (1), pp.7. ⟨10.1016/j.bpc.2009.08.003⟩. ⟨hal-00579023⟩
  • Marie Breton, Jeanne Leblond, Johanne Seguin, Patrick Midoux, Daniel Scherman, et al.. Comparative gene transfer between cationic and thiourea lipoplexes. The Journal of Gene Medicine, 2009, 12 (1), pp.45-54. ⟨10.1002/jgm.1417⟩. ⟨hal-02512540⟩
  • Jeanne Leblond, Nathalie Mignet, Celine Largeau, Johanne Seguin, Daniel Scherman, et al.. Lipopolythiourea Transfecting Agents: Lysine Thiourea Derivatives. Bioconjugate Chemistry, 2007, ⟨10.1021/bc7001924⟩. ⟨hal-02512550⟩
  • Jeanne Leblond, Nathalie Mignet, Lucie Leseurre, Celine Largeau, Michel Bessodes, et al.. Design, Synthesis, and Evaluation of Enhanced DNA Binding New Lipopolythioureas. Bioconjugate Chemistry, In press, ⟨10.1021/bc060110g⟩. ⟨hal-02512562⟩
  • Nathalie Mignet, Le Masne de Chermont Quentin, Randrianarivelo Tatiana, Seguin Johanne, Richard Cyrille, et al.. Liposome biodistribution by time resolved fluorimetry of lipophilic europium complexes. European Biophysics Journal, 2006, 35 (2), pp.155-161. ⟨inserm-00162498⟩
  • Jeanne Leblond, Nathalie Mignet, Lucie Leseurre, Céline Largeau, Michel Bessodes, et al.. Design, synthesis, and evaluation of enhanced DNA binding new lipopolythioureas.. Bioconjugate Chemistry, 2006, 17 (5), pp.1200-8. ⟨10.1021/bc060110g⟩. ⟨inserm-00165275⟩

Conference papers7 documents

  • Simona Manta, Anthony Delalande, Gilles Renault, Michel Francis Bureau, Matthias Lebertre, et al.. Positively charged microbubbles to target nucleic acid delivery with ultrasound. Journées RITS 2015, Mar 2015, Dourdan, France. ⟨inserm-01154976⟩
  • Caroline J Thébault, Grégory Ramniceanu, Johanne Seguin, Aude Michel, Claire Beauvineau, et al.. Multimodal RM and Optic Imaging using ultramagnetic liposomes to monitor a cancer therapy. Journées RITS 2015, Mar 2015, Dourdan, France. p16-17 Section nanomédecine. ⟨inserm-01143980⟩
  • Wassef Khaled, Benjamin Leporq, J.H Wan, Philippe Garteiser, Simon A. Lambert, et al.. Distinction between pro and anti-inflammatory macrophages using MRI relaxometry and quantitative susceptibility mapping. 23th International Society of Magnetic Resonance in Medicine annual meeting, May 2015, Toronto, Canada. ⟨hal-01918412⟩
  • Gregory Ramniceanu, Bich-Thuy Doan, Camille Vezignol, Alain Graillot, Quentin Crouzet, et al.. Phosphonate PEG Copolymers to control the USPIO stealthiness. Journées RITS 2015, Mar 2015, Dourdan, France. p20-21. ⟨inserm-01145542⟩
  • Mickaël Garnier, Maya Alsheh Ali, Johanne Seguin, Nathalie Mignet, Thomas Hurtut, et al.. Grading cancer from liver histology images using inter and intra region spatial relations. International Conference on Image Analysis and Recognition, Oct 2014, Portugal. pp.247-254. ⟨hal-01063797⟩
  • Maya Alsheh Ali, Johanne Seguin, Aurélie Fisher, Nathalie Mignet, Laurent Wendling, et al.. Comparison of the Spatial Organization in Colorectal Tumors using Second-Order Statistics and Functional ANOVA. Image and Signal Processing and Analysis (ISPA), 2013 8th International Symposium on, 2013, Italy. pp.257 - 261, ⟨10.1109/ISPA.2013.6703749⟩. ⟨hal-00992369⟩
  • M. Alsheh Ali, J. Seguin, A. Fischer, Nathalie Mignet, L. Wendling, et al.. Comparison of the Spatial Organization in Colorectal Tumors using Second-Order Statistics and Functional ANOVA. Image and Signal Processing and Analysis (ISPA), 2013 8th International Symposium on, 2013, Trieste, Italy. pp.257-261, ⟨10.1109/ISPA.2013.6703749⟩. ⟨hal-01020634⟩

Book sections2 documents

  • Michel Bessodes, Helene Dhotel, Nathalie Mignet. Lipids for Nucleic Acid Delivery: Cationic or Neutral Lipoplexes, Synthesis, and Particle Formation. Methods Mol. Biol, pp.123-139, 2019. ⟨hal-02123120⟩
  • Nathalie Mignet, Corinne Marie, Anthony Delalande, Simona Manta, Johanne Seguin, et al.. Microbubbles for Nucleic Acid Delivery in Liver Using Mild Sonoporation. Nanotechnology for Nucleic Acid Delivery, pp.377-387, 2019, Methods in Molecular Biology, ⟨10.1007/978-1-4939-9092-4_25⟩. ⟨hal-02123117⟩