Nicolas Sergeant

66
Documents

Présentation

Nicolas Sergeant is a full-time research director at Inserm UMRS 1172 Alzheimer & Tauopathies group. He is dedicated to understanding the mechanisms underlying neurodegeneration by identifying biomarkers and therapeutic targets for a family of neurological disorders called Tauopathies. He earned his degree in Biology of Aging in 1994 from the University of Paris Diderot VII/Paris Cité. His Ph.D. focused on characterizing the biochemical signatures of neurological disorders, all of which involve neurofibrillary degeneration characterized by different sets of microtubule-associated Tau proteoform aggregates. He joined Inserm in 2000 as a full-time researcher and began investigating the relationship between the lesion processes of Alzheimer's disease, specifically amyloid and Tau pathology. He developed various methods and tools to understand, identify biological markers, and explore therapeutic options to slow or halt neurodegenerative diseases, including Alzheimer’s Disease and Myotonic Dystrophy. He pioneered novel proteomics techniques to analyze protein aggregates, created biological systems for drug screening and structure-activity relationship studies, and developed polyclonal and monoclonal antibodies as well as transgenic models for studying Tau splicing, seeding, and propagation. His expertise also encompasses medicinal chemistry, therapeutic strategy design, and the development of immunological assays, as well as core skills in biochemistry and molecular biology. He holds 11 patents and has collaborated with pharmaceutical companies such as Alzprotect, Sanofi, Innogenetics, Pfizer, Biogen, and Servier to develop biomarkers and small-molecule drugs targeting Tauopathies and Alzheimer's disease. Notably, Ezeprogind, one of these compounds, recently completed a Phase II clinical trial for Supranuclear Palsy. He also contributed to gene therapy research for myotonic dystrophy, a neuromuscular disorder within the RNAopathy family characterized by Tau mis-splicing, neurofibrillary degeneration, and cognitive impairment, and translation to the clinic is held by Genethon. Nicolas Sergeant has authored over a hundred articles. He serves on numerous committees, including the operational committee of Foundation Plan Alzheimer, the Scientific Committee of L’Association France Alzheimer, the AFM task force on myotonic dystrophy, and the scientific committee of the International DMyotonic dystrophy Congress. He is also an associate editor for Frontiers in Neurology and the Exploration of Neuroprotective Therapy Journal.

Publications

Publications

Stability over Time of the Sperm Motility Biomarker proAKAP4 in Repeated Dog Ejaculates

Giulia Siena , Alain Fontbonne , Barbara Contiero , Cindy Maenhoudt , Guillaume Robiteau et al.
Animals, 2025, 15 (8), pp.1160. ⟨10.3390/ani15081160⟩
Article dans une revue hal-05080097 v1
Image document

ProAKAP4 as a motility long-lasting marker in Catalan donkey spermatozoa

Marta Dordas-Perpinyà , Nicolas Sergeant , Iván Yánez-Ortiz , Vincent Mevel , Jaime Catalán et al.
Animal Reproduction Science, 2024, pp.107427. ⟨10.1016/j.anireprosci.2024.107427⟩
Article dans une revue hal-04451177 v1

ProAKAP4 as a motility long-lasting marker in Catalan donkey spermatozoa

Marta Dordas-Perpinyà , Nicolas Sergeant , Iván Yánez-Ortiz , Vincent Mevel , Jaime Catalán et al.
Animal Reproduction Science, 2024, 262, pp.107427. ⟨10.1016/j.anireprosci.2024.107427⟩
Article dans une revue hal-05291644 v1
Image document

ProAKAP4 as Indicator of Long-Lasting Motility Marker in Post-Thaw Conditions in Stallions

Marta Dordas-Perpinyà , Iván Yánez-Ortiz , Nicolas Sergeant , Vincent Mevel , Jaime Catalán et al.
Animals, 2024, 14 (9), pp. 1264. ⟨10.3390/ani14091264⟩
Article dans une revue hal-04557009 v1
Image document

A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid Pathology

Marie Tautou , Florian Descamps , Paul-Emmanuel Larchanché , Luc Buée , Jamal El Bakali et al.
International Journal of Molecular Sciences, 2023, 24 (6), pp.5285. ⟨10.3390/ijms24065285⟩
Article dans une revue hal-04345588 v1

ProAKAP4 protein marker: Towards a functional approach to male fertility

Sara Carracedo , Lamia Briand-Amirat , Marta Dordas-Perpinyà , Yolanda Ramos Escuredo , Romain Delcombel et al.
Animal Reproduction Science, 2022, 247, pp.107074. ⟨10.1016/j.anireprosci.2022.107074⟩
Article dans une revue hal-05291658 v1
Image document

Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men.

Hamza Benderradji , Anne-Laure Barbotin , M. Leroy-Billiard , J. Prasivoravong , F. Marcelli et al.
Journal of Clinical Endocrinology and Metabolism, 2022, The Journal of clinical endocrinology & metabolism, 107 (7), p. 1878-1887. ⟨10.1210/clinem/dgac218⟩
Article dans une revue hal-04450259 v1

ProAKAP4 protein marker: Towards a functional approach to male fertility

Sara Carracedo , Lamia Briand-Amirat , Marta Dordas-Perpinyà , Yolanda Ramos Escuredo , Romain Delcombel et al.
Animal Reproduction Science, 2022, 247, pp.107074. ⟨10.1016/j.anireprosci.2022.107074⟩
Article dans une revue hal-04225735 v1
Image document

Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

Isabel Paiva , Lucrezia Cellai , Céline Meriaux , Lauranne Poncelet , Ouada Nebie et al.
The Journal of clinical investigation, 2022, 132 (12), ⟨10.1172/JCI149371⟩
Article dans une revue hal-03855350 v1

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

Hamza Benderradji , Sarra Kraiem , Emilie Courty , Sabiha Eddarkaoui , Cyril Bourouh et al.
Frontiers in Molecular Neuroscience, 2022, 15, ⟨10.3389/fnmol.2022.841892⟩
Article dans une revue hal-04470461 v1

ProAKAP4 Semen Concentrations as a Valuable Marker Protein of Post-Thawed Semen Quality and Bull Fertility: A Retrospective Study

Marta Dordas-Perpinyà , Nicolas Sergeant , Isabelle Ruelle , Jean-François Bruyas , Frédéric Charreaux et al.
Veterinary Sciences, 2022, 9 (5), pp.224. ⟨10.3390/vetsci9050224⟩
Article dans une revue hal-04225724 v1
Image document

Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration

Lee-Hsin Wang , Chien-Yu Lin , Yu-Mei Lin , Luc Buée , Nicolas Sergeant et al.
Journal of Neuroscience, 2022, pp.JN-RM-2006-21. ⟨10.1523/JNEUROSCI.2006-21.2022⟩
Article dans une revue inserm-03699311 v1
Image document

Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats

Ludovic Arandel , Magdalena Matloka , Arnaud F Klein , Frédérique Rau , Alain Sureau et al.
Nature Biomedical Engineering, 2022, 6 (2), pp.207-220. ⟨10.1038/s41551-021-00838-2⟩
Article dans une revue hal-03830811 v1

ProAKAP4 Semen Concentrations as a Valuable Marker Protein of Post-Thawed Semen Quality and Bull Fertility: A Retrospective Study

Marta Dordas-Perpinyà , Nicolas Sergeant , Isabelle Ruelle , Jean-François Bruyas , Frédéric Charreaux et al.
Veterinary Sciences, 2022, 9 (5), pp.224. ⟨10.3390/vetsci9050224⟩
Article dans une revue hal-05291662 v1
Image document

Impact of chronic doxycycline treatment in the APP/PS1 mouse model of Alzheimer's disease

Victoria Gomez-Murcia , Kevin Carvalho , Bryan Thiroux , Raphaëlle Caillierez , Melanie Besegher et al.
Neuropharmacology, 2022, 209, pp.108999. ⟨10.1016/j.neuropharm.2022.108999⟩
Article dans une revue inserm-03699325 v1
Image document

Pharmacomodulations around an anti-Alzheimer drug-candidate

Sylvain Marc , Christophe Mésangeau , Mathilde Coevoet , Amélie Barczyk , Stéphane Burlet et al.
European Journal of Medicinal Chemistry Reports, 2022, 4, pp.100020. ⟨10.1016/j.ejmcr.2021.100020⟩
Article dans une revue hal-04403572 v1
Image document

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

Hamza Benderradji , Sarra Kraiem , Emilie Courty , Sabiha Eddarkaoui , Cyril Bourouh et al.
Frontiers in Molecular Neuroscience, 2022, 15, pp.841892. ⟨10.3389/fnmol.2022.841892⟩
Article dans une revue inserm-03699324 v1
Image document

Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles

Christophe Mesangeau , Pascal Carato , Nicolas Renault , Mathilde Coevoet , Paul-Emmanuel Larchanché et al.
International Journal of Molecular Sciences, 2022, 23 (21), pp.13111. ⟨10.3390/ijms232113111⟩
Article dans une revue hal-04035715 v1
Image document

ProAKAP4 Concentration Is Related to Sperm Motility and Motile Sperm Subpopulations in Frozen–Thawed Horse Semen

Marta Dordas-Perpinyà , Ivan Yanez-Ortiz , Nicolas Sergeant , Vincent Mevel , Jean-François Bruyas et al.
Animals, 2022, 12 (23), pp.3417. ⟨10.3390/ani12233417⟩
Article dans une revue hal-04225730 v1

ProAKAP4 Concentration Is Related to Sperm Motility and Motile Sperm Subpopulations in Frozen–Thawed Horse Semen

Marta Dordas-Perpinyà , Ivan Yanez-Ortiz , Nicolas Sergeant , Vincent Mevel , Jean-François Bruyas et al.
Animals, 2022, 12 (23), pp.3417. ⟨10.3390/ani12233417⟩
Article dans une revue hal-05291652 v1

ProAKAP4 protein marker: Towards a functional approach to male fertility

Sara Carracedo , Lamia Briand-Amirat , Marta Dordas-Perpinyà , Yolanda Ramos Escuredo , Romain Delcombel et al.
Animal Reproduction Science, 2022, 247, pp.107074. ⟨10.1016/j.anireprosci.2022.107074⟩
Article dans une revue hal-05291676 v1
Image document

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

Marie Tautou , Sabiha Eddarkaoui , Florian Descamps , Paul-Emmanuel Larchanché , Jamal El Bakali et al.
Frontiers in Pharmacology, 2021, 12, pp.679335. ⟨10.3389/fphar.2021.679335⟩
Article dans une revue inserm-03366685 v1

Correction to: Gel Electrophoresis of Human Sperm: A Simple Method for Evaluating Sperm Protein Quality

Fanny Jumeau , Julien Sigala , Francisco-Jose Fernandez-Gomez , Sabiha Eddarkaoui , Sophie Duban-Deweer et al.
Basic and clinical andrology, 2020, 30, pp.4. ⟨10.1186/s12610-020-00102-8⟩
Article dans une revue hal-05149844 v1
Image document

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Nicolas Sergeant , Valérie Vingtdeux , Sabiha Eddarkaoui , Marion Gay , Caroline Evrard et al.
Neurobiology of Disease, 2019, 129, p.217-233. ⟨10.1016/j.nbd.2019.03.028⟩
Article dans une revue inserm-02350071 v1
Image document

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Emilie Faivre , Joana Coelho , Katja Zornbach , Enas Malik , Younis Baqi et al.
Frontiers in Molecular Neuroscience, 2018, 11, pp.235. ⟨10.3389/fnmol.2018.00235⟩
Article dans une revue inserm-01930489 v1
Image document

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

Marion Gay , Pascal Carato , Mathilde Coevoet , Nicolas Renault , Paul-Emmanuel Larchanché et al.
Bioorganic and Medicinal Chemistry, 2018, 26 (8), pp.2151-2164. ⟨10.1016/j.bmc.2018.03.016⟩
Article dans une revue hal-02060708 v1
Image document

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

Thomas Goiran , Eric Duplan , Mounia Chami , Alexandre Bourgeois , Wejdane El Manaa et al.
Biological Psychiatry, 2018, 83 (5), pp.416-427. ⟨10.1016/j.biopsych.2017.04.011⟩
Article dans une revue hal-02360864 v1
Image document

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Caroline Evrard , Pascal Kieulen-Campard , Mathilde Coevoet , Rémi Opsomer , Bernadette Tasiaux et al.
Frontiers in Cellular Neuroscience, 2018, 12, pp.435. ⟨10.3389/fncel.2018.00435⟩
Article dans une revue hal-02060617 v1
Image document

A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors

Marion Gay , Caroline Evrard , Florian Descamps , Pascal Carato , Nicolas Renault et al.
European Journal of Medicinal Chemistry, 2018, 159, pp.104-125. ⟨10.1016/j.ejmech.2018.08.092⟩
Article dans une revue hal-04035729 v1

Defining the human sperm microtubulome: an integrated genomics approach

Fanny Jumeau , Frédéric Chalmel , Francisco-Jose Fernandez-Gomez , Celine Carpentier , Hélène Obriot et al.
Biology of Reproduction, 2017, 96 (1), pp.93-106. ⟨10.1095/biolreprod.116.143479⟩
Article dans une revue hal-01515563 v1
Image document

Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies

Nicolas Barthélemy , Audrey Gabelle , Christophe Hirtz , François Fenaille , Nicolas Sergeant et al.
Journal of Alzheimer's Disease, 2016, 51 (4), pp.1033 - 1043. ⟨10.3233/JAD-150962⟩
Article dans une revue hal-01842422 v1

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity

Nicolas Barthélemy , François Fenaille , Christophe Hirtz , Nicolas Sergeant , Susanna Schraen-Maschke et al.
Journal of Proteome Research, 2016, 15 (2), pp.667 - 676. ⟨10.1021/acs.jproteome.5b01001⟩
Article dans une revue hal-01842426 v1
Image document

Regulation of human MAPT gene expression

Marie-Laure Caillet-Boudin , Luc Buée , Nicolas Sergeant , Bruno Lefebvre
Molecular Neurodegeneration, 2015, 10 (1), pp.28. ⟨10.1186/s13024-015-0025-8⟩
Article dans une revue inserm-04532389 v1
Image document

Chloroquine and Chloroquinoline Derivatives as Models for the Design of Modulators of Amyloid Peptide Precursor Metabolism

Patricia Melnyk , Valérie Vingtdeux , Stéphane Burlet , Sabiha Eddarkaoui , Marie-Eve Grosjean et al.
ACS Chemical Neuroscience, 2015, 6 (4), pp.559-569. ⟨10.1021/cn5003013⟩
Article dans une revue hal-02060814 v1
Image document

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

Maxime Derisbourg , Coline Leghay , Giovanni Chiappetta , Francisco-Jose Fernandez-Gomez , Cyril Laurent et al.
Scientific Reports, 2015, 5 (1), ⟨10.1038/srep09659⟩
Article dans une revue hal-01659458 v1

Human Spermatozoa as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project.

Fanny Jumeau , Emmanuelle Com , Lydie Lane , Paula Duek , Mélanie Lagarrigue et al.
Journal of Proteome Research, 2015, 14 (9), pp.3606-20. ⟨10.1021/acs.jproteome.5b00170⟩
Article dans une revue hal-03023878 v1
Image document

Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation

Anthony Papegaey , Sabiha Eddarkaoui , Vincent Deramecourt , Francisco-Jose Fernandez-Gomez , Pierre Pantano et al.
Acta Neuropathologica Communications, 2015, 4 (1), pp.74. ⟨10.1186/s40478-016-0345-0⟩
Article dans une revue inserm-01346896 v1
Image document

MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway

Audrey Bouillez , Viviane Gnemmi , Kelly Gaudelot , Brigitte Hemon , Bélinda Ringot et al.
Oncotarget, 2014
Article dans une revue hal-02905860 v1
Image document

RBFOX1 Cooperates with MBNL1 to Control Splicing in Muscle, Including Events Altered in Myotonic Dystrophy Type 1

Roscoe Klinck , Angélique Fourrier , Philippe Thibault , Johanne Toutant , Mathieu Durand et al.
PLoS ONE, 2014, 9 (9), pp.e107324. ⟨10.1371/journal.pone.0107324⟩
Article dans une revue hal-01365880 v1
Image document

MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway

Audrey Bouillez , Viviane Gnemmi , Kelly Gaudelot , Brigitte Hémon , Bélinda Ringot et al.
Oncotarget, 2014, 5 (3), pp.754-763. ⟨10.18632/oncotarget.1768⟩
Article dans une revue hal-03313775 v1

Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2

C. Carpentier , D. Ghanem , F. J. Fernandez-Gomez , F. Jumeau , J. V. Philippe et al.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2014, 1842 (4), pp.654-664. ⟨10.1016/j.bbadis.2014.01.004⟩
Article dans une revue hal-01453196 v1
Image document

Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.

Oscar Hernández-Hernández , Céline Guiraud-Dogan , Géraldine Sicot , Aline Huguet , Sabrina Luilier et al.
Brain - A Journal of Neurology , 2013, 136 (Pt 3), pp.957-70. ⟨10.1093/brain/aws367⟩
Article dans une revue inserm-00795195 v1

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.

Kunie Ando , Pierre Dourlen , Anne-Véronique Sambo , Alexis Bretteville , Karim Bélarbi et al.
Neurobiol Aging, 2013, 34 (3), pp.757-69. ⟨10.1016/j.neurobiolaging.2012.08.004⟩
Article dans une revue istex hal-00765859 v1
Image document

MBNL1 gene variants as modifiers of disease severity in myotonic dystrophy type 1

Vincent Huin , Francis Vasseur , Susanna Schraen-Maschke , Claire-Marie Dhaenens , Patrick Devos et al.
Journal of Neurology, 2013, 260 (4), pp.998-1003. ⟨10.1007/s00415-012-6740-y⟩
Article dans une revue istex hal-03555357 v1
Image document

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.

Laëticia Troquier , Raphaëlle Caillierez , Sylvie Burnouf , Francisco J. Fernandez-Gomez , Marie-Eve Grosjean et al.
Curr Alzheimer Res, 2012, 9 (4), pp.397-405
Article dans une revue inserm-00664452 v1
Image document

Mis-splicing of Tau exon 10 in myotonic dystrophy type I is reproduced by overexpression of CELF2 but not by MBNL1 silencing

C.M. Dhaenens , H. Tran , M.-L. Frandemiche , C. Carpentier , S. Schraen-Maschke et al.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2011, ⟨10.1016/j.bbadis.2011.03.010⟩
Article dans une revue hal-00694732 v1
Image document

Analysis of Exonic Regions Involved in Nuclear Localization, Splicing Activity, and Dimerization of Muscleblind-like-1 Isoforms

Helene Tran , Nathalie Gourrier , Camille Lemercier-Neuillet , Claire-Marie Dhaenens , Audrey Vautrin et al.
Journal of Biological Chemistry, 2011, 286 (18), pp.16435 - 16446. ⟨10.1074/jbc.M110.194928⟩
Article dans une revue hal-01738403 v1

Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

Charlotte Fugier , Arnaud F Klein , Caroline Hammer , Stéphane Vassilopoulos , Ylva Ivarsson et al.
Nature Medicine, 2011, 17 (6), pp.720-5. ⟨10.1038/nm.2374⟩
Article dans une revue hal-00811986 v1

Comment les acteurs moléculaires de la pathologie Alzheimer permettent de comprendre la démence ? Quelles conséquences diagnostiques et thérapeutiques ?

Luc Buée , David Blum , Stephanie Bombois , Valérie Buée-Scherrer , Marie-Laure Caillet-Boudin et al.
Alternative and Complementary Therapies, 2010, 65 (5), pp.401-407. ⟨10.2515/therapie/2010054⟩
Article dans une revue istex hal-03093376 v1
Image document

Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

Karim Belarbi , Katharina Schindowski , Sylvie Burnouf , Raphaëlle Caillierez , Marie-Eve Grosjean et al.
Current Alzheimer Research, 2009, 6 (2), pp.152-7
Article dans une revue inserm-00375282 v1
Image document

Tau as a biomarker of neurodegenerative diseases.

Susanna Schraen-Maschke , Nicolas Sergeant , Claire-Marie Dhaenens , Stephanie Bombois , Vincent Deramecourt et al.
Biomarkers in Medicine, 2008, 2 (4), pp.363-84. ⟨10.2217/17520363.2.4.363⟩
Article dans une revue inserm-00375314 v1

Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats

Claire-Marie Dhaenens , Susanna Schraen-Maschke , Ha Tran , Valérie Vingtdeux , Dana Ghanem et al.
Experimental Neurology, 2008, 210 (2), pp.467-478. ⟨10.1016/j.expneurol.2007.11.020⟩
Article dans une revue istex hal-00282892 v1

Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles.

Cahora Medina-Palazon , Henri Gruffat , Fabrice Mure , Odile Filhol , Valérie Vingtdeux-Didier et al.
Journal of Virology, 2007, 81 (21), pp.11850-60. ⟨10.1128/JVI.01421-07⟩
Article dans une revue inserm-00413477 v1

Pin1 allows for differential Tau dephosphorylation in neuronal cells.

Malika Hamdane , Pierre Dourlen , Alexis Bretteville , Anne-Véronique Sambo , Stéphanie Ferreira et al.
Molecular and Cellular Neuroscience, 2006, 32, pp.155-160
Article dans une revue hal-00085645 v1

Expression of human FE65 in Amyloid Precursor Protein transgenic mice is associated with a reduction in beta-Amyloid load

Dominique Santiard-Baron , Dominique Langui , Maryse Delehedde , Benoit Delatour , Brigitte Schombert et al.
Journal of Neurochemistry, 2005, 93 (2), pp.330-8. ⟨10.1111/j.1471-4159.2005.03026.x⟩
Article dans une revue hal-00173286 v1

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.

Valérie Vingtdeux , Malika Hamdane , Marie Gompel , Severine Begard , Hervé Drobecq et al.
Neurobiology of Disease, 2005, 20, pp.625-37
Article dans une revue hal-00098664 v1

Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities

H. Seznec , O. Agbulut , Nicolas Sergeant , C. Savouret , Antoine Ghestem et al.
Human Molecular Genetics, 2001, 10, pp.2717-2726
Article dans une revue hal-00179658 v1

Concentrations of ProAKAP4 as indicators of sperm quality in commonly used bull semen extenders

Perrine Thery , Marta Dordas-Perpinyà , Vincent Mevel , Hamed Farnia , Jean‐françois Bruyas et al.
1st European Symposium on Animal Reproduction, Sep 2023, Nantes (44000), France. pp.198
Communication dans un congrès hal-04369058 v1

Decoy gene therapy to reverse RNA toxicity in DM1

Ludovic Arandel , Arnaud F Klein , Frédérique Rau , Alain Sureau , Aurélien Cordier et al.
International Myotonic Dystrophy Consortium Meeting IDMC-13, International Myotonic Dystrophy Consortium, May 2022, Osaka, Japan
Communication dans un congrès hal-03999213 v1

Sperm-specific protein proAKAP4 as a marker to evaluate sperm quality and fertility of Alpine and Saanen Bucks

Alice Fatet , Nicolas Sergeant , M. Dordas-Perpinyà , B. Drouet , O. Ponthoreau et al.
25. Annual Conference of the Eureopean Society for Domestic Animal Reproduction (ESDAR), Sep 2022, Thessaloniki, Greece. Reproduction in Domestic Animals, 57 (S4), pp.79-79, 2022, Proceedings of the 25th Annual Conference of the Eureopean Society for Domestic Animal Reproduction (ESDAR). ⟨10.1111/rda.14244⟩
Poster de conférence hal-03839750 v1

A decoy-based gene therapy targeting CUGexp-DMPK transcripts in DM1

Magdalena Matloka , Ludovic Arandel , Arnaud Klein , Michel Ney , Alain Sureau et al.
6th International Myology Congress, Mar 2019, Bordeaux, France
Poster de conférence hal-04002587 v1

A Decoy-Based Gene Therapy to Inhibit RNA Toxicity Associated with Expanded CUG

Ludovic Arandel , Magdalena Matloka , Arnaud Klein , Joelle Marie , Frédérique Rau et al.
International Myotonic Dystrophy Consortium Meeting IDMC-12, Jun 2019, Gothenburg, Sweden
Poster de conférence hal-04002563 v1

A decoy-based gene therapy targeting CUGexp-DMPK transcripts in DM1

Ludovic Arandel , Magdalena Matloka , Arnaud Klein , Arnaud Ferry , Frédérique Rau et al.
International Myotonic Dystrophy Consortium Meeting IDMC-11, Sep 2017, San Fransisco, United States
Poster de conférence hal-04002607 v1

Frontotemporal lobar degenerations, RNAopathy leading to proteinopathies

Vincent Anquetil , Anne Bertrand , Agnès Camuzat , Pierre de La Grange , Clémence Fournier et al.
AAIC 2017 - Alzheimer's Association International Conference, Jul 2017, Londres, United Kingdom. 13 (7), 2017, ⟨10.1016/j.jalz.2017.06.1982⟩
Poster de conférence hal-01672304 v1