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Pascal Reboul

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Osteoarthritis is the most common disease in the elderly. Indeed, 65% of people over 60 years of age have osteoarthritis. Despite the high prevalence of osteoarthritis, its pathophysiology is not clearly established, especially since osteoarthritis is a multifactorial disease. The initial definition of osteoarthritis as the degeneration of cartilage with cyclic inflammatory phases under the dependence of the synovial membrane (the membrane surrounding the joint) is somewhat simplistic. Indeed, it is now accepted that bone and in particular subchondral bone (bone under the cartilage) plays a role in the arthritic process. One of the characteristics of osteoarthritis is an attempt to repair **cartilage** by chondrocytes (cartilage cells), but this repair fails, particularly under the influence of factors secreted by the **synovial membrane** and **subchondral bone**. These factors can concurrently increase cartilage degradation and decrease repair, but also cause chondrocytes to dedifferentiate and return to expressing genes normally found in growth plates (conjugation cartilage) or during bone repair (endochondral ossification). Among the different re-expressed genes are those of **collagenase-3** (MMP-13) and **galectin-3**. One of the growth factors found in greater quantity in osteoarthritic cartilage is **hepatocyte growth factor** (HGF). However, its synthesis is restricted to **osteoblasts** (bone cells), which suggests a paracrine role of this factor. In addition, in human **chondrocytes**, this HGF stimulates the production of collagenase-3, which is involved in cartilage remodeling and destruction, via the mitogen-activated protein kinases (MAPK) pathway. During their de-differentiation, osteoarthritic chondrocytes also express and produce larger quantities of galectin-3, which is a lectin with different functions depending on its intra- or extracellular distribution. Although osteoarthritic chondrocytes produce more galectin-3, they secrete only small amounts. However, its intracellular presence is beneficial for chondrocytes since animals deficient in galectin-3 develop more osteoarthritis than non-mutated animals. In addition, using in vitro experiments, galectin-3 has a protective role against chondrocyte death. These results highlight the role of galectin-3 in cartilage homeostasis. However, animals deficient in galectin-3 do not have subchondral bone abnormalities except in the induction of osteoarthritis by intra-articular injection of mono-iodoacetate. These results show that galectin-3 does not appear to be essential for bone homeostasis, but when bone is subjected to metabolic stress, the absence of intracellular galectin-3 is harmful. In contrast, galectin-3 can be secreted by the synovial membrane during inflammatory phases. During the latter, the synovial membrane generates a specific structure called pannus that envelops the cartilage and bone. Galectin-3 secretion can therefore directly reach chondrocytes and osteoblasts. Using chondrocytes, galectin-3 induces the expression of two major enzymes involved in the degradation of proteoglycans, one of the major components of the cartilage matrix. Galectin-3 also stimulates the expression of type X collagen, another cartilage compound normally expressed in the growth plate. Incubation of arthrosic osteoblasts in the presence of galectin-3 decreases the expression of osteocalcin, which is a marker of terminal osteoblast differentiation. According to literature,a truncated form of galectin-3, capable of binding to galectin-3 ligands but without activating a cellular signal, does not have this effect. Several strategies in order to produce **a Trc-gal-3**, devoid of biological activities was developed in the lab. Unfortunately, all of them presented biological effects on osteoarthritic chondrocytes. Among the Trc-gal-3 forms developed, one was selected because it had enough affinity for lactose and a great solubility. Thanks to theses properties, **this form is used to generate a new method of purification of recombinant proteins**.

Research domains



Specificity of severe AKI aetiology and care in the elderly. The IRACIBLE prospective cohort study

Antoine Cardinale , Ziyad Messikh , Valery Antoine , Cédric Aglae , Pascal Reboul
Journal of Nephrology, 2022, ⟨10.1007/s40620-022-01322-z⟩
Journal articles hal-03714055v1
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Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis

Narjès Hafsia , Marine Forien , Félix Renaudin , Delphine Delacour , Pascal Reboul
International Journal of Molecular Sciences, 2020, 21 (4), pp.1486. ⟨10.3390/ijms21041486⟩
Journal articles hal-02935722v1
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Identification of TGFβ signatures in six murine models mimicking different osteoarthritis clinical phenotypes

Marie Maumus , Danièle Noël , Hang Korng Ea , David Moulin , Maxime Ruiz
Osteoarthritis and Cartilage, 2020, 28 (10), pp.1373-1384. ⟨10.1016/j.joca.2020.06.008⟩
Journal articles hal-02899374v1
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Tofacitinib treatment alters mucosal immunity and gut microbiota during experimental arthritis

Julie Hablot , Maroua Ferhat , Aonghus Lavelle , Fatouma Salem , Mahdia Taieb
Clinical and Translational Medicine, 2020, 10 (5), pp.e163. ⟨10.1002/ctm2.163⟩
Journal articles hal-03005532v1
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Accompagnement dans l’apprentissage de l’argumentation par une équipe pluridisciplinaire : quels effets sur les acteurs?

Martine Paindorge , Virginie Lang , Virginie Libante , Pascal Reboul , Bertrand Aigle
Revue internationale de pédagogie de l’enseignement supérieur, 2020, 36 (2), ⟨10.4000/ripes.2717⟩
Journal articles hal-03041936v1
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CRD SAT generated by pCARGHO: A new efficient lectin-based affinity tag method for safe, simple and low-cost protein purification

Alexandre Kriznik , Melissa Yelehe-Okouma , Christophe Lec , Guillaume Groshenry , Hélène Le Cordier
Biotechnology Journal, 2019, 14 (4), pp.e1800214. ⟨10.1002/biot.201800214⟩
Journal articles hal-01892441v1
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ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors

G Vargas , M Bouchet , L Bouazza , P Reboul , C Boyault
Oncogene, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩
Journal articles hal-02353108v1
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Galectin-3: A key player in arthritis

Yong Hu , Mélissa Yéléhé-Okouma , Hang-Korng Ea , Jean-Yves Jouzeau , Pascal Reboul
Joint Bone Spine, 2017, 84 (1), pp.15-20. ⟨10.1016/j.jbspin.2016.02.029⟩
Journal articles hal-01704704v1
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The infrapatellar fat pad induces inflammatory and degradative effects in articular cells but not through leptin or adiponectin

Jean-Baptiste Gross , Cecile Guillaume , Pascal Gegout-Pottie , Pascal Reboul , Jean-Yves Jouzeau
Clinical and experimental rheumatology, 2017, 35 (1), pp.53-60
Journal articles hal-01532184v1
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Basic science of osteoarthritis

Magali Cucchiarini , Laura de Girolamo , Giuseppe Filardo , J. Miguel Miguel Oliveira , Patrick Orth
Journal of Experimental Orthopaedics, 2016, 3 (1), pp.22. ⟨10.1186/s40634-016-0060-6⟩
Journal articles hal-01705047v1

Fibroblast Growth Factor 23 drives MMP13 expression in human osteoarthritic chondrocytes in a Klotho-independent manner

A. Bianchi , M. Guibert , F. Cailotto , Alain Gasser , N. Presle
Osteoarthritis and Cartilage, 2016, 24 (11), pp.1961-1969. ⟨10.1016/j.joca.2016.06.003⟩
Journal articles hal-01452316v1

Identification of two populations of osteoarthritic osteoblasts according to the 1,25[OH](2) vitamin D-3 potency to stimulate osteocalcin

Yong Hu , Yang Liu , Daniel Lajeunesse , Didier Mainard , Jean-Yves Jouzeau
Bio-Medical Materials and Engineering, 2015, 25 (1), pp.S103-S110. ⟨10.3233/BME-141230⟩
Journal articles hal-01452238v1

Elevated hepatocyte growth factor levels in osteoarthritis osteoblasts contribute to their altered response to bone morphogenetic protein-2 and reduced mineralization capacity

E. Abed , B. Bouvard , X. Martineau , J.-Y. Jouzeau , P. Reboul
BONE, 2015, 75, pp.111-119. ⟨10.1016/j.bone.2015.02.001⟩
Journal articles hal-02921974v1

Oxidative stress-induced expression of HSP70 contributes to the inhibitory effect of 15d-PGJ(2) on inducible prostaglandin pathway in chondrocytes

Arnaud Bianchi , D. Moulin , S. Hupont , M. Koufany , P. Netter
Free Radical Biology and Medicine, 2014, 76, pp.114-126. ⟨10.1016/j.freeradbiomed.2014.07.028⟩
Journal articles hal-01453217v1
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Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts

Béatrice Bouvard , Elie Abed , Mélissa Yéléhé-Okouma , Arnaud Bianchi , Didier Mainard
Arthritis Research and Therapy, 2014, 16 (5), pp.459. ⟨10.1186/s13075-014-0459-3⟩
Journal articles hal-01471845v1

Osteoarthritis: rationale for a new paradigm shift involving transforming growth factor-β1

Pascal Reboul , Jean-Yves Jouzeau , Daniel Lajeunesse
OA Arthritis, 2013, 1 (1), pp.10. ⟨10.13172/2052-9554--1-702⟩
Journal articles hal-01473925v1

Galectin-3 mediates aldosterone-induced vascular fibrosis.

Laurent Calvier , Maria Miana , Pascal Reboul , Victoria Cachofeiro , Ernesto Martinez-Martinez
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (1), pp.67-75. ⟨10.1161/ATVBAHA.112.300569⟩
Journal articles hal-00812594v1

Articular cartilage calcification in osteoarthritis: Insights into crystal-induced stress

Hang-Korng Ea , Christelle Nguyen , Dominique Bazin , Arnaud Bianchi , Jérome Guicheux
Arthritis & rheumatology, 2011, 63 (1), pp.10 - 18. ⟨10.1002/art.27761⟩
Journal articles hal-01705871v1
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Calcium Input Potentiates the Transforming Growth Factor (TGF)-β1-dependent Signaling to Promote the Export of Inorganic Pyrophosphate by Articular Chondrocyte

Frederic Cailotto , Pascal Reboul , Sylvie Sébillaud , Patrick Netter , Jean-Yves Jouzeau
Journal of Biological Chemistry, 2011, 286 (22), pp.19215-19228. ⟨10.1074/jbc.M110.175448⟩
Journal articles hal-01704454v1

Estrogen receptor-related receptor α regulation by interleukin-1β in prostaglandin E2- and cAMP-dependent pathways in osteoarthritic chondrocytes

Edith E Bonnelye , Pascal Reboul , Nicolas Duval , Marco Cardelli , Jane Aubin
Arthritis and Rheumatism, 2011, 63 (8), pp.2374-2384. ⟨10.1002/art.30398⟩
Journal articles hal-01705064v1

Intracellular localisation of galectin-3 has a protective role in chondrocyte survival

C. Boileau , P. Poirier , P Pelletier , M Guévremont , N Duval
Annals of the Rheumatic Diseases, 2008, 67 (2), pp.175 - 181. ⟨10.1136/ard.2006.066514⟩
Journal articles hal-01704462v1

Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis

J. Monfort , G. Tardif , P. Roughley , P. Reboul , C. Boileau
Osteoarthritis and Cartilage, 2008, 16 (7), pp.749 - 755. ⟨10.1016/j.joca.2007.11.007⟩
Journal articles hal-01705873v1
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Extracellular localization of galectin-3 has a deleterious role in joint tissues

Audrée Janelle-Montcalm , Christelle Boileau , Françoise Poirier , Jean-Pierre Pelletier , Mélanie Guévremont
Arthritis Research and Therapy, 2007, 9 (1), pp.R20. ⟨10.1186/ar2130⟩
Journal articles hal-01704438v1
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Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site

Jordi Monfort , Ginette Tardif , Pascal Reboul , François Mineau , Peter Roughley
Arthritis Research and Therapy, 2006, 8 (1), pp.R26. ⟨10.1186/ar1873⟩
Journal articles hal-01705700v1

Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.

Patrick Marcouiller , Pierre Pelletier , Mélanie Guévremont , Johanne Martel-Pelletier , Pierre Ranger
Journal of Rheumatology, 2005, pp.704-12
Journal articles hal-01705121v1
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The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases

Jean-Pierre Pelletier , Christelle Boileau , Martin Boily , Julie Brunet , François Mineau
Arthritis Research and Therapy, 2005, 7 (5), pp.R1091. ⟨10.1186/ar1788⟩
Journal articles hal-01705710v1

Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis

P. Lavigne , M. Benderdour , D. Lajeunesse , P. Reboul , Q. Shi
Osteoarthritis and Cartilage, 2005, 13 (4), pp.310 - 317. ⟨10.1016/j.joca.2004.12.015⟩
Journal articles hal-01705735v1

Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3)

Ginette Tardif , Pascal Reboul , Jean-Pierre Pelletier , Johanne Martel-Pelletier
Modern Rheumatology, 2004, 14 (3), pp.197-204. ⟨10.1007/s10165-004-0292-7⟩
Journal articles hal-01705132v1

The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K

Jean-Pierre Pelletier , Christelle Boileau , Julie Brunet , Martin Boily , Daniel Lajeunesse
BONE, 2004, 34 (3), pp.527 - 538. ⟨10.1016/j.bone.2003.11.021⟩
Journal articles hal-01705856v1

Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3

Mélanie Guevremont , Johanne Martel-Pelletier , Christelle Boileau , Ft Liu , Michel Richard
Annals of the Rheumatic Diseases, 2004, 63 (6), pp.636 - 643. ⟨10.1136/ard.2003.007229⟩
Journal articles hal-01704652v1

Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B4 in osteoarthritic chondrocytes: Role of transforming growth factor ? and eicosanoids

Johanne Pelletier , François Mineau , Hassan Fahmi , Stefan Laufer , Pascal Reboul
Arthritis and Rheumatism, 2004, 50 (12), pp.3925 - 3933. ⟨10.1002/art.20632⟩
Journal articles hal-01705750v1

Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites

G. Tardif , M. Dupuis , P. Reboul , C.S Geng , Jean Pelletier
Osteoarthritis and Cartilage, 2003, 11 (7), pp.524 - 537. ⟨10.1016/S1063-4584(03)00079-7⟩
Journal articles hal-01705862v1

Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling.

Daniel Lajeunesse , Pascal Reboul
Current Opinion in Rheumatology, 2003, pp.628-33
Journal articles hal-01705858v1

Acid-induced Conformational Changes in Phosphoglucose Isomerase Result in Its Increased Cell Surface Association and Deposition on Fibronectin Fibrils

Mohammad Amraei , Zongjian Jia , Pascal Reboul , Ivan R Nabi
Journal of Biological Chemistry, 2003, 278 (40), pp.38935 - 38941. ⟨10.1074/jbc.M304778200⟩
Journal articles hal-01705860v1

Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

Johanne Martel-Pelletier , Daniel Lajeunesse , Pascal Reboul , Jean-Pierre Pelletier
Annals of the Rheumatic Diseases, 2003, 62 (6), pp.501 - 509. ⟨10.1136/ard.62.6.501⟩
Journal articles hal-01705863v1

Human Adult Chondrocytes Express Hepatocyte Growth Factor (HGF) Isoforms but Not HGF: Potential Implication of Osteoblasts on the Presence of HGF in Cartilage

Mélanie Guévremont , Johanne Pelletier , Frédéric Massicotte , Ginette Tardif , Pierre Pelletier
Journal of Bone and Mineral Research, 2003, 18 (6), pp.1073 - 1081. ⟨10.1359/jbmr.2003.18.6.1073⟩
Journal articles hal-01704559v1

Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta.

Mohamed Benderdour , Ginette Tardif , Pierre Pelletier , John Di Battista , Pascal Reboul
Journal of Rheumatology, 2002, pp.1262-72
Journal articles hal-01705867v1

Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening.

Qin Shi , Daniel Lajeunesse , Pascal Reboul , Johanne Pelletier , Jean-Pierre Pelletier
Journal of Rheumatology, 2002, pp.1437-45
Journal articles hal-01705866v1

Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation.

Dragan Jovanovic , François Mineau , Kohei Notoya , Pascal Reboul , Johanne Pelletier
Journal of Rheumatology, 2002, pp.2165-75
Journal articles hal-01705864v1

In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin-1β synthesis

Dragan Jovanovic , Julio C. Fernandes , Johanne Pelletier , François-Cyril Jolicoeur , Pascal Reboul
Arthritis and Rheumatism, 2001, 44 (10), pp.2320-2330. ⟨10.1002/1529-0131(200110)44:10<2320::AID-ART394>3.0.CO;2-P⟩
Journal articles hal-01705269v1

Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: Involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade

Pascal Reboul , Jean-Pierre Pelletier , Ginette Tardif , Mohamed Benderdour , Pierre Ranger
Arthritis and Rheumatism, 2001, 44 (1), pp.73 - 84. ⟨10.1002/1529-0131(200101)44:1<73::AID-ANR11>3.0.CO;2-E⟩
Journal articles hal-01705308v1

Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites.

G Tardif , P. Reboul , M. Dupuis , C. Geng , N Duval
Journal of Rheumatology, 2001, pp.1631-9
Journal articles hal-01705281v1

Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.

Jean Pelletier , J. Fernandes , J Jovanovic , P. Reboul , J. Martel-Pelletier
Journal of Rheumatology, 2001, pp.2509-19
Journal articles hal-01705868v1

Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages.

D Jovanovic , J Di Battista , J. Martel-Pelletier , P. Reboul , Y. He
Journal of Rheumatology, 2001, pp.712-8
Journal articles hal-01705579v1

Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.

Jean Pelletier , D Lajeunesse , P. Reboul , F Mineau , J. Fernandes
Journal of Rheumatology, 2001, pp.814-24
Journal articles hal-01705289v1

Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro

M. Piperno , P. Reboul , M Hellio Le Graverand , M J Peschard , M Annefeld
Osteoarthritis and Cartilage, 2000, 8 (3), pp.207 - 212. ⟨10.1053/joca.1999.0291⟩
Journal articles hal-01705629v1

The Induction of Cell Death in Human Osteoarthritis Chondrocytes by Nitric Oxide Is Related to the Production of Prostaglandin E 2 Via the Induction of Cyclooxygenase-2

Kohei Notoya , Dragan Jovanovic , P. Reboul , Johanne Martel-Pelletier , François Mineau
Journal of Immunology, 2000, 165 (6), pp.3402-3410. ⟨10.4049/jimmunol.165.6.3402⟩
Journal articles hal-01705606v1

Osteoarthritic cartilage fibrillation is associated with a decrease in chondrocyte adhesion to fibronectin.

Muriel Piperno , P. Reboul , Marie-Pierre Hellio Le Graverand , Mj Peschard , Marliese Annefeld
Osteoarthritis and Cartilage, 1998, 6 (6), pp.393-399. ⟨10.1053/joca.1998.0138⟩
Journal articles hal-01705650v1

Phospholipase A2 activity in herniated lumbar discs. Clinical correlations and inhibition by piroxicam.

M. Piperno , M Hellio Le Graverand , P. Reboul , M. Mathieu , M Tron
Spine, 1997, pp.2061-5
Journal articles hal-01705664v1

IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients.

S Tavera , T Abribat , P. Reboul , S Doré , P Brazeau
Osteoarthritis and Cartilage, 1996, pp.263-74
Journal articles hal-01705669v1

Study ofO-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid

Pascal Reboul , Pascal George , Delphine Miquel , Pierre Louisot , Pierre Broquet
Glycoconjugate Journal, 1996, 13 (1), pp.69 - 79. ⟨10.1007/BF01049682⟩
Journal articles hal-01705189v1
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The New Collagenase, Collagenase-3, Is Expressed and Synthesized by Human Chondrocytes but not by Synoviocytes A Role in Osteoarthritis

P. Reboul , Jean-Pierre Pelletier , Ginette Tardif , Jean-Marie Cloutier , Johanne Martel-Pelletier
Journal of Clinical Investigation, 1996, 97 (9), pp.2011-2019. ⟨10.1172/JCI118636⟩
Journal articles hal-01705146v1

Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins.

Ginette Tardif , Pascal Reboul , Jean-Pierre Pelletier , Changshan Geng , Jean-Marie Cloutier
Arthritis and Rheumatism, 1996, 39 (6), pp.968-978. ⟨10.1002/art.1780390614⟩
Journal articles hal-01705166v1

Study of retinoic acid effect upon retinoic acid receptors beta (RAR-beta) in C6 cultured glioma cells.

P. Reboul , P George , P. Louisot , P. Broquet
Biochemistry and molecular biology international, 1995, pp.1097-105
Journal articles hal-01705678v1

Study of o-glycan sialylation in c6 cultured glioma cells: Regulation of a β-galactoside α2,3 sialyltransferase activity by ca2+/calmodulin antagonists and phosphatase inhibitors

Pascal Reboul , Pascal George , Jocelyne Geoffroy , Pierre Louisot , Pierre Broquet
Biochemical and Biophysical Research Communications, 1992, 186 (3), pp.1575 - 1581. ⟨10.1016/S0006-291X(05)81587-6⟩
Journal articles hal-01705216v1

Study of O-glycan sialylation in C6 cultured glioma cells: Evidence for post-translational regulation of Aβ-galactoside α2,3 sialyltransferase activity by N-glycosylation

Pierre Broquet , Pascal George , Jocelyne Geoffroy , Pascal Reboul , Pierre Louisot
Biochemical and Biophysical Research Communications, 1991, 178 (3), pp.1437 - 1443. ⟨10.1016/0006-291X(91)91054-G⟩
Journal articles hal-01705236v1

Effect of retinoic acid on two glycosyltransferase activities in c6 cultured glioma cells

Pascal Reboul , Pierre Broquet , Pascal George , Pierre Louisot
The International journal of biochemistry, 1990, 22 (8), pp.889 - 893. ⟨10.1016/0020-711X(90)90293-C⟩
Journal articles hal-01705242v1

Efficient new lectin-based affinity tag allowing simple, safe and low-cost recombinant protein purification

Alexandre Kriznik , Melissa Yelehe-Okouma , Christophe Charron , Hortense Mazon , Hélène Le Cordier
The 14th International Symposium on BioChromatography and Nanoseparations, May 2018, Bordeaux, France
Conference papers hal-01719814v1

Le domaine «Netrin-Like» de la protéine sFRP3 module les effets Wnts-dépendants dans les cellules et tissus articulaires

Akim Chayem , Guillaume Toussaint , Marion Claudel , Pascal Reboul , Jean-Yves Jouzeau
30ème Congrès Français de Rhumatologie (SFR), Dec 2017, Paris, France. pp.A263 (PE.Ma-004)
Conference papers hal-01775284v1

FRI0017 Pharmacological Blockade of CCR3 Reduces Collagen-Induced Arthritis Severity

J. Hablot , M. Koufany , P. Reboul , J.-Y. Jouzeau , D. Moulin
Annual European Congress of Rheumatology (EULAR), 2016, Londres, United Kingdom. pp.431.3 - 432, ⟨10.1136/annrheumdis-2016-eular.4069⟩
Conference papers hal-01706984v1

Galectin 3 exerts a protective role in a murine model of osteoarthritis

N. Hafsia , F. Poirier , D. Delacour , Pascal Reboul , D. Côme
EULAR 2014, Jun 2014, Paris, France. pp.796
Conference papers hal-01511612v1

Hypoxia and vitamin D contribute to leptin and DKK2 production in human osteoarthritic subchondral bone osteoblasts

Béatrice Bouvard , Elie Abed , Melissa Yelehe-Okouma , Arnaud Bianchi , Didier Mainard
2014 Annual Meeting of the American Society for Bone and Mineral Research, Sep 2014, Houston, United States. pp.S161
Conference papers hal-01511623v1

Expression of HSP70 by oxidative stress contributes to the inhibitory effect of 15d-PGJ2 on inducible prostaglandin pathway in chondrocyte

Arnaud Bianchi , David Moulin , Sebastien Hupont , Meriem Koufany , Patrick Netter
10ème Congrès de la Société Française de Pharmacologie & Thérapeutique (SFP&T), Apr 2015, Caen, France. Fundamental and Clinical Pharmacology, 29 (Suppl 1), pp.31, 2015
Conference poster hal-01775312v1

Sirtuins as markers of bone disease: a focus on osteoarthritis and osteoporosis

Elie Abed , Pascal Reboul , Daniel Lajeunesse
Vinood B. Patel, Victor R. Preedy. Biomarkers in Bone Disease. Biomarkers in Disease: Methods, Discoveries and Applications, Springer publisher, pp.157-175, 2017, 978-94-007-7745-3 (online) - 978-94-007-7692-0 (print). ⟨10.1007/978-94-007-7693-7_41⟩
Book sections hal-01709897v1

The role of bone in the development of osteoarthritis.

Daniel Lajeunesse , P. Reboul
F Bronner and MC Farach-Carson. Bone and Osteoarthritis, 4, pp.19-39, 2007, Topics in Bone Biology
Book sections hal-01710478v1

The role of subchondral bone in osteoarthritis

Johanne Martel-Pelletier , Daniel Lajeunesse , Pascal Reboul , Jean-Pierre Pelletier
Leena Sharma & Francis Berenbaum. Osteoarthritis, first edition, Mosby Elsevier publisher, pp.15-32, 2007
Book sections hal-01709917v1