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Patrick Dallemagne

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Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents

Mirjana Antonijevic , Despoina Charou , Audrey Davis , Thomas Curel , Maria Valcarcel
Molecules, 2024, 29 (2), pp.515. ⟨10.3390/molecules29020515⟩
Journal articles hal-04414817v1

Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease

Thomas Guiselin , Cédric Lecoutey , Christophe Rochais , Patrick Dallemagne
Pharmaceutics, 2023, 15 (10), pp.2382. ⟨10.3390/pharmaceutics15102382⟩
Journal articles hal-04414828v1
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C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug

Mirjana Antonijevic , Christophe Rochais , Patrick Dallemagne
Molecules, 2023, 28 (2), pp.679. ⟨10.3390/molecules28020679⟩
Journal articles hal-03969919v1
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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

Rim Malek , Alexey Simakov , Audrey Davis , Maciej Maj , Paul Bernard
Molecules, 2023, 28 (1), pp.71. ⟨10.3390/molecules28010071⟩
Journal articles hal-03969932v1

Advances in prodrug design for Alzheimer’s disease: the state of the art

Valentin Travers--Lesage , Serge Mignani , Patrick Dallemagne , Christophe Rochais
Expert Opinion on Drug Discovery, 2022, 17 (4), pp.325-341. ⟨10.1080/17460441.2022.2031972⟩
Journal articles hal-03969939v1
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Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy

Cédric Lecoutey , Rémi Legay , Audrey Davis , Jana Sopková-de Oliveira Santos , Patrick Dallemagne
Molecules, 2021, 26 (9), pp.2536. ⟨10.3390/molecules26092536⟩
Journal articles hal-03969972v1
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First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease

Benjamin Guieu , Cedric Lecoutey , Rémi Legay , Audrey Davis , Jana Sopkova de Oliveira Santos
Molecules, 2021, 26 (1), pp.80. ⟨10.3390/molecules26010080⟩
Journal articles hal-03969980v1
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Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy

Benjamin Guieu , Jean-Pierre Jourdan , Aurore Dreneau , Nicolas Willand , Christophe Rochais
Drug Discovery Today, 2021, 26 (2), pp.315-328. ⟨10.1016/j.drudis.2020.11.026⟩
Journal articles hal-03969988v1
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
Journal articles hal-03082877v1

Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Pauline Zipfel , Julien Lalut , Jana Sopková-de Oliveira Santos , Christophe Rochais , Patrick Dallemagne
Synthesis: Journal of Synthetic Organic Chemistry, 2021, 53 (20), pp.3799-3814. ⟨10.1055/a-1523-1409⟩
Journal articles hal-03969969v1

5-HT4R modulators: a patent landscape

Patrick Dallemagne , Christophe Rochais
Pharmaceutical Patent Analyst, 2021, 10 (4), pp.179-181. ⟨10.4155/ppa-2021-0017⟩
Journal articles hal-03969965v1
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Donecopride, a Swiss army knife with potential interest against Alzheimer's disease

Christophe Rochais , Cédric Lecoutey , Katia Hamidouche , Patrizia Giannoni , Florence Gaven
British Journal of Pharmacology, inPress, 177 (9), pp.1988-2005. ⟨10.1111/bph.14964⟩
Journal articles hal-02428730v1
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Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment

Thomas Adnet , Anne-Claire Groo , Céline Picard , Audrey Davis , Sophie Corvaisier
Pharmaceutics, 2020, 12 (3), pp.251. ⟨10.3390/pharmaceutics12030251⟩
Journal articles hal-03969997v1
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Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Lauralie Peronne , Eric Denarier , Ankit Rai , Renaud Prudent , Audrey Vernet
Cancers, 2020, 12 (8), pp.2196. ⟨10.3390/cancers12082196⟩
Journal articles hal-03034449v1
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Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis

Songuigama Coulibaly , Mena Cimino , Mahama Ouattara , Cédric Lecoutey , Maria V Buchieri
European Journal of Medicinal Chemistry, 2020, 207, pp.112821. ⟨10.1016/j.ejmech.2020.112821⟩
Journal articles pasteur-03261309v1
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Drug repositioning: a brief overview

Jean-Pierre Jourdan , Ronan Bureau , Christophe Rochais , Patrick Dallemagne
Journal of Pharmacy and Pharmacology, 2020, 72 (9), pp.1145-1151. ⟨10.1111/jphp.13273⟩
Journal articles hal-03961788v1
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Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)

Caroline Lanthier , Patrick Dallemagne , Cédric Lecoutey , Sylvie Claeysen , Cédric Lecoutey
Expert Opinion on Therapeutic Patents, 2020, ⟨10.1080/13543776.2020.1767587⟩
Journal articles hal-02863879v1
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Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease

Julien Lalut , Hugo Payan , Audrey Davis , Cédric Lecoutey , Rémi Legay
Scientific Reports, 2020, 10, pp.3014. ⟨10.1038/s41598-020-59805-7⟩
Journal articles hal-02485740v1
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Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: dataset of 2,891 compounds

Côme Thieulent , Christine Fortier , Hélène Munier-Lehmann , Peggy Suzanne , Patrick Dallemagne
Data in Brief, 2020, 33, pp.106492. ⟨10.1016/j.dib.2020.106492⟩
Journal articles hal-03022297v1
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Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors

José-Carlos Valle-Casuso , Delphine Gaudaire , Lydie Martin-Faivre , Anthony Madeline , Patrick Dallemagne
Scientific Reports, 2020, 10 (1), pp.10100. ⟨10.1038/s41598-020-66944-4⟩
Journal articles inserm-02888514v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

Caroline Lanthier , Hugo Payan , Irene Liparulo , Bérénice Hatat , Cédric Lecoutey
European Journal of Medicinal Chemistry, 2019, 182, pp.111596. ⟨10.1016/j.ejmech.2019.111596⟩
Journal articles hal-02399942v1
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A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

Bérénice Hatat , Samir Yahiaoui , Cédric Lecoutey , Audrey Davis , Thomas Freret
Frontiers in Aging Neuroscience, 2019, 11, pp.148. ⟨10.3389/fnagi.2019.00148⟩
Journal articles hal-02399864v1
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A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth

Ferdousse Laggoun , Flavien Dardelle , Jérémy Dehors , Denis Falconet , Azeddine Driouich
BMC Plant Biology, 2019, 19, pp.152. ⟨10.1186/s12870-019-1743-9⟩
Journal articles hal-02106475v1

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Julien Lalut , Gianluca Santoni , Delphine Karila , Cédric Lecoutey , Audrey Davis
European Journal of Medicinal Chemistry, 2019, 162, pp.234-248. ⟨10.1016/j.ejmech.2018.10.064⟩
Journal articles hal-01994096v1
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New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Nicolas Sergeant , Valérie Vingtdeux , Sabiha Eddarkaoui , Marion Gay , Caroline Evrard
Neurobiology of Disease, 2019, 129, pp.217-233. ⟨10.1016/j.nbd.2019.03.028⟩
Journal articles inserm-02350071v1
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Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease

François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis
Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Journal articles hal-02399906v1

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

Côme Thieulent , Erika Hue , Christine Fortier , Patrick Dallemagne , Stéphan Zientara
Virology, 2019, 526, pp.105-116. ⟨10.1016/j.virol.2018.10.013⟩
Journal articles hal-01968305v1
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26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

Patrick Dallemagne , Christophe Rochais , Pascal Marchand , Thierry Besson
Pharmaceuticals, 2019, 12 (2), pp.73. ⟨10.3390/ph12020073⟩
Journal articles hal-02330438v1

Modulating 5-HT 4 and 5-HT 6 receptors in Alzheimer’s disease treatment

Julien Lalut , Delphine Karila , Patrick Dallemagne , Christophe Rochais
Future Medicinal Chemistry, 2017, 9 (8), pp.781-795. ⟨10.4155/fmc-2017-0031⟩
Journal articles hal-02043735v1

Multifaceted properties of 1,4-dimethylcarbazoles: Focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors

Domenico Iacopetta , Camillo Rosano , Francesco Puoci , Ortensia Ilaria Parisi , Carmela Saturnino
European Journal of Pharmaceutical Sciences, 2017, 96, pp.263-272. ⟨10.1016/j.ejps.2016.09.039⟩
Journal articles hal-02043748v1

The 52 nd International Conference on Medicinal Chemistry (RICT 2016) of the French Medicinal Chemistry Society (SCT) Held in Caen (Normandy)

Janos Sapi , Luc Van hijfte , Patrick Dallemagne
ChemMedChem, 2017, 12 (12), pp.862-871. ⟨10.1002/cmdc.201700336⟩
Journal articles hal-02043722v1

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

Jean-Pierre Jourdan , Marc Since , Laïla El kihel , Cédric Lecoutey , Sophie Corvaisier
ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩
Journal articles hal-02043731v1

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography

Julien Lalut , Benjamin B. Tournier , Thomas Cailly , Cédric Lecoutey , Sophie Corvaisier
European Journal of Medicinal Chemistry, 2016, 116, pp.90-101. ⟨10.1016/j.ejmech.2016.03.059⟩
Journal articles hal-02011098v1

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

Jean-Pierre Jourdan , Marc Since , Laïla El Kihel , Cédric Lecoutey , Sophie Corvaisier
European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩
Journal articles hal-02043765v1

3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression

Pietro Rizza , Michele Pellegrino , Anna Caruso , Domenico Iacopetta , Maria Stefania Sinicropi
European Journal of Medicinal Chemistry, 2016, 107, pp.275-287. ⟨10.1016/j.ejmech.2015.11.004⟩
Journal articles hal-02043777v1

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease

Samir Yahiaoui , Katia Hamidouche , Céline Ballandonne , Audrey Davis , Jana Sopkova-de Oliveira Santos
European Journal of Medicinal Chemistry, 2016, 121, pp.283-293. ⟨10.1016/j.ejmech.2016.05.048⟩
Journal articles hal-02043759v1

6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands

Paul-Emmanuel Larchanche , Vincent Ultré , Delphine Le Broc , Céline Ballandonne , Christophe Furman
European Journal of Medicinal Chemistry, 2015, 92, pp.807-817. ⟨10.1016/j.ejmech.2015.01.052⟩
Journal articles hal-01116521v1

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

Anne Quiedeville , Michel Boulouard , Katia Hamidouche , Virginie da Silva Costa-Aze , Gerald Nee
Behavioural Brain Research, 2015, 293, pp.10-17. ⟨10.1016/j.bbr.2015.07.020⟩
Journal articles hal-02043824v1

Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities

Maria Fatima Pereira , Christophe Rochais , Patrick Dallemagne
Anti-Cancer Agents in Medicinal Chemistry, 2015, 15 (9), pp.1080-1091. ⟨10.2174/1871520615666150520143600⟩
Journal articles hal-02043788v1

Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium

Anita Cohen , Peggy Suzanne , Jean-Charles Lancelot , Pierre Verhaeghe , Aurélien Lesnard
European Journal of Medicinal Chemistry, 2015, 95, pp.16-28. ⟨10.1016/j.ejmech.2015.03.011⟩
Journal articles hal-01460555v1

Therapeutic Potential of 5-HT 6 Receptor Agonists

Delphine Karila , Thomas Freret , Valentine Bouet , Michel Boulouard , Patrick Dallemagne
Journal of Medicinal Chemistry, 2015, 58 (20), pp.7901-7912. ⟨10.1021/acs.jmedchem.5b00179⟩
Journal articles hal-02043781v1

Indenopyrazole oxime ethers: Synthesis and β1-adrenergic blocking activity

Tomaso Angelone , Anna Caruso , Christophe Rochais , Angela Caputa , Maria Cerra
European Journal of Medicinal Chemistry, 2015, 92, pp.672-681. ⟨10.1016/j.ejmech.2015.01.037⟩
Journal articles hal-01116512v1
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Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

Cédric Lecoutey , Cédric Lecoutey , Florence Gaven , Patrizia Giannoni , Katia Hamidouche
Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩
Journal articles hal-02043873v1

Synthesis and evaluation of cytotoxic activities of new guanidines derived from carbazoles.

Anna Caruso , Maria Stefania Sinicropi , Jean-Charles Lancelot , Hussein El-Kashef , Carmela Saturnino
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (2), pp.467-72. ⟨10.1016/j.bmcl.2013.12.047⟩
Journal articles hal-00945836v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Journal articles hal-01800439v2
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Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents

Nicolas Primas , Peggy Suzanne , Pierre Verhaeghe , Sébastien Hutter , Charline Kieffer
European Journal of Medicinal Chemistry, 2014, 83, pp.26-35. ⟨10.1016/j.ejmech.2014.06.014⟩
Journal articles hal-01417058v1

N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.

Dominique Brossard , Ying Zhang , Shozeb Haider , Miriam Sgobba , Mohamed Khalid
Chemical Biology and Drug Design, 2013, 82 (5), pp.620-629. ⟨10.1111/cbdd.1219⟩
Journal articles hal-00918445v1

MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.

Christophe Rochais , Thierry Cresteil , Vittoria Perri , Marie Jouanne , Aurélien Lesnard
Cancer Letters, 2013, 331 (1), pp.92-8. ⟨10.1016/j.canlet.2012.12.017⟩
Journal articles hal-00807871v1

Tripentones: A Promising Series of Potent Anti-Cancer Agents.

Christophe Rochais , Sylvain Rault , Patrick Dallemagne
Anti-Cancer Agents in Medicinal Chemistry, 2013, 2, pp.313-343
Journal articles hal-00840950v1

An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one.

Jean-Pierre Jourdan , Christophe Rochais , Rémi Legay , Jana Sopkova-de Oliveira Santos , Patrick Dallemagne
Tetrahedron Letters, 2013, 54 (9), pp.1133-1136
Journal articles hal-00821455v1

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

David Genest , Christophe Rochais , Cédric Lecoutey , Jana Sopkova-de Oliveira Santos , Céline Ballandonne
MedChemComm, 2013, 4, pp.925-931
Journal articles hal-00840942v1

Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.

Cédric Lecoutey , Christophe Rochais , David Genest , Sabrina Butt-Gueulle , Céline Ballandonne
MedChemComm, 2012, 3, pp.627-634
Journal articles hal-00764795v1

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

Elizabeth Chosson , Francesca Santoro , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Rémi Legay
Bioorganic and Medicinal Chemistry Letters, 2012, 20 (8), pp.2614-2623. ⟨10.1016/j.bmc.2012.02.043⟩
Journal articles hal-02357753v1

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice.

Thomas Freret , Valentine Bouet , Anne Quiedeville , Gerald Nee , Patrick Dallemagne
Behavioural Brain Research, 2012, 230, pp.304-308
Journal articles hal-00821461v1

2,5-Dimethoxytetrahydrofuran, first update.

Christophe Rochais , Patrick Dallemagne
Encyclopedia of Reagents for Organic Synthesis, 2012, pp.2012
Journal articles hal-00821463v1

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Thomas Freret , Valentine Bouet , Anne Quiedeville , Gérald Nee , Patrick Dallemagne
Behavioural Brain Research, 2012, 230 (1), pp.304-8. ⟨10.1016/j.bbr.2012.02.012⟩
Journal articles hal-00862757v1

First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids

Elizabeth Chosson , Christophe Rochais , Rémi Legay , Jana Sopkova-de Oliveira Santos , Sylvain Rault
Tetrahedron, 2011, 67 (14), pp.2548-2554. ⟨10.1016/j.tet.2011.02.026⟩
Journal articles hal-01018072v1

One-pot synthesis of new aza- and diaza-aminopenanthrenes

Christophe Rochais , Rodrigue Yougnia , Thomas Cailly , Jana Sopkova-de Oliveira Santos , Sylvain Rault
Tetrahedron, 2011, 67 (32), pp.5806-5810. ⟨10.1016/j.tet.2011.05.116⟩
Journal articles hal-01061754v1

Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity

Vittoria Perri , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Rémi Legay , Thierry Cresteil
European Journal of Medicinal Chemistry, 2010, 45 (3), pp.1146-1150. ⟨10.1016/j.ejmech.2009.12.021⟩
Journal articles hal-02045946v1

One-pot synthesis of novel poly-substituted phenanthrenes

Rodrigue Yougnia , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Patrick Dallemagne , Sylvain Rault
Tetrahedron, 2010, 66 (15), pp.2803-2808. ⟨10.1016/j.tet.2010.02.060⟩
Journal articles hal-02045958v1

Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity

Christophe Rochais , Sylvain Rault , Patrick Dallemagne
Current Medicinal Chemistry, 2010, 17 (35), pp.4342-4369
Journal articles hal-02045949v1

Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library

Jana Sopkova-de Oliveira Santos , Aurélien Lesnard , Jean-Hugues Agondanou , Nathalie Dupont , Anne-Marie Godard
Journal of Chemical Information and Modeling, 2010, 50 (3), pp.422-428. ⟨10.1021/ci900491t⟩
Journal articles hal-00705935v1

Synthesis, reactivity and biological evaluation of novel halogenated tripentones.

Vittoria Perri , Christophe Rochais , Thierry Cresteil , Patrick Dallemagne , Sylvain Rault
Bioorganic and Medicinal Chemistry, 2009, 17 (22), pp.7783-8. ⟨10.1016/j.bmc.2009.09.027⟩
Journal articles hal-00433244v1

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.

Christophe Rochais , Nghia Vu Duc , Elodie Lescot , Jana Sopkova-de Oliveira Santos , Ronan Bureau
European Journal of Medicinal Chemistry, 2008, epub ahead of print. ⟨10.1016/j.ejmech.2008.05.011⟩
Journal articles hal-00319802v1

Synthesis of new 4-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors.

Céline Vidaillac , Jean Guillon , Stéphane Moreau , Corinne Arpin , Annie Lagardère
Journal of Enzyme Inhibition and Medicinal Chemistry, 2007, 22 (5), pp.620-31
Journal articles hal-00319134v1

Synthesis, Antimalarial Activity, and Molecular Modeling of New Pyrrolo[1,2- a ]quinoxalines, Bispyrrolo[1,2- a ]quinoxalines, Bispyrido[3,2- e ]pyrrolo[1,2- a ]pyrazines, and Bispyrrolo[1,2- a ]thieno[3,2- e ]pyrazines

Jean Guillon , Philippe Grellier , Mehdi Labaied , Pascal Sonnet , Jean-Michel Léger
Journal of Medicinal Chemistry, 2004, 47 (8), pp.1997-2009. ⟨10.1021/jm0310840⟩
Journal articles mnhn-02867477v1

Pyrrolothieno[1,4]diazepines. Part V. Study of their chemical reactivity and first synthesis of oxazino[4,3- c ]pyrrolo[1,2- a ]thieno[2,3- f ] [1,4]diazepines

Michel Boulouard , Patrick Dallemagne , Sylvain Rault
Journal of Heterocyclic Chemistry, 1997, 34 (4), pp.1219-1225. ⟨10.1002/jhet.5570340420⟩
Journal articles hal-03970074v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin
XXVèmes Journées Francophones de Virologie, Société Française de Virologie, Apr 2023, Paris, France
Conference papers hal-04481153v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin
36th International Conference on Antiviral Research, International Society for Antiviral Research (ISAR), Mar 2023, Lyon, France
Conference papers hal-04481101v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin
Journées Scientifiques et Doctorales de l'ANSES (JSDA), ANSES, Oct 2022, Maisons-Alfort, France
Conference papers hal-04481141v1

Two- and three-dimensional in vitro models for investigating TBEV-induced neuropathogenesis and discovering therapeutic drugs

Noémie Berry , Mazigh Fares , Gaëlle Gonzalez , Anne Huard de Verneuil , Noemie Aurine
Journées "Tiques et Maladies à Tiques", Groupe "Tiques et Maladies à Tiques" (TMT), Mar 2022, Nancy, France
Conference papers hal-04481097v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin
Journées d’Animation Scientifiques du Département de Santé Animale, INRAE (Département de Santé Animale), Oct 2022, Aglet, France
Conference papers hal-04481147v1

Identification of antiviral compounds against equid herpesvirus‐1 using Real‐Time Cell Analysis: screening of 2,891 molecules

Côme Thieulent , Erika Hue , Gabrielle Sutton , Christine Fortier , Patrick Dallemagne
11th International Equine Infectious Diseases Conference, Sep 2021, Online, France. ⟨10.1111/evj.83_13495⟩
Conference papers hal-03405801v1

Development of a high‐throughput screening assay to identify equine virus arteritis replication inhibitors

Gabrielle Bouet , Delphine Gaudaire , A. Madeline , Patrick Dallemagne , Stéphane Pronost
11th International Equine Infectious Diseases Conference, Sep 2021, Online, France. pp.63-64, ⟨10.1111/evj.95_13495⟩
Conference papers hal-03374819v1
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Un nouvel arsenal thérapeutique contre la rhinopneumonie équine

Côme Thieulent , Erika Hue , Christine Fortier , Patrick Dallemagne , Stéphan Zientara
Journées sciences et innovations équines 2020, Nov 2020, Le Pin au Haras, France
Conference papers hal-03219395v1

Development of a high- throughput cell-based assay to determine anti-equine arteritis virus properties of chemical compounds

Gaël Amelot , Delphine Gaudaire , Patrick Dallemagne , Stéphane Pronost , Stéphan Zientara
Emerging Infectious Diseases Congress, Apr 2016, Buenos Aires, Argentina
Conference papers hal-02953721v1

Modeling SARS-COV2-infected central nervous system using human neuronal/glial cells to identify antiviral drugs

Noémie Berry , Nazim Ahnou , Rozenn Brillet , François Piumi , Dennis Salomón López-Molina
36th International Conference on Antiviral Research, Mar 2023, Lyon, France
Conference poster hal-04481047v1

Modeling SARS-COV2-infected central nervous system using human neuronal-glial cells to identify antirviral drugs

Noémie Berry , Nazim Ahnou , Rozenn Brillet , François Piumi , Dennis Salomón López-Molina
XXVèmes Journées Francophones de Virologie, Apr 2023, Paris, France
Conference poster hal-04481111v1

Modeling SARS-COV2-infected central nervous system using human neuronal/glial cells to identify antiviral drugs

Noémie Berry , Nazim Ahnou , Rozenn Brillet , François Piumi , Dennis Salomón López-Molina
Nouvelles stratégies antivirales : de la recherche à clinique - New antiviral strategies: form bench to bedside., Apr 2023, Paris, France
Conference poster hal-04481120v1

Tick-Borne Encephalitis Virus-infected human neuronal/glial cells identify antiviral drugs

Noémie Berry , Gaëlle Gonzalez , Anne Huard de Verneuil , Valentine Chaillot , Marielle Cochet-Bernoin
36th International Conference on Antiviral Research, Mar 2023, Lyon, France
Conference poster hal-04480802v1

Purine and pyrimidine biosynthesis inhibitors efficiently suppress equine arteritis virus replication

José-Carlos Valle-Casuso , Delphine Gaudaire , A. Madeline , Patrick Dallemagne , Stéphane Pronost
11th International Equine Infectious Diseases Conference, Sep 2021, Online, France. Equine veterinary journal, 53 (S56), pp.64-65, 2021, Special Issue: Abstracts of the 11th International Equine Infectious Diseases Conference. ⟨10.1111/evj.97_13495⟩
Conference poster hal-03374831v1

Development of a nasal drug delivery composite nanosystem for Alzheimer’s desease treatment

Adnet Thomas , Anne-Claire Groo , Loïc Le Pluart , Celine Picard , A. Davis
Journée normande de recherche biomédicale, Nov 2017, caen, France
Conference poster hal-02295929v1

Virtual screening search for HIF-2alpha selective inhibitors

Jana Sopkova-de Oliveira Santos , L Belkhacem-Bouricha , Karim Bordji , Stroiazzo R , Patrick Dallemagne
RICT 2016 International conference on medicinal chemistry, 52èmes Rencontres Internationales de Chimie Thérapeutique, Jul 2016, Caen, France
Conference poster hal-02273754v1