PV

Patrick Vourc'h

Professeur des Universités-Praticien Hospitalier, Université de Tours, Faculté de médecine, CHU de Tours, Hôpital Bretonneau
47 %
Libre accès
91
Documents
Affiliations actuelles
  • Imaging, Brain & Neuropsychiatry (iBraiN)
  • Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)
  • Université de Tours (UT)
Identifiants chercheurs
Contact

Domaines de recherche

Sciences du Vivant [q-bio]

Compétences

Biologie moléculaire génétique biochimie neurosciences

Publications

Publications

Gut metabolomic and microbiota analyses in ALS mice reveal specific metabolites despite the absence of significant gut dysbiosis

Charlotte Veyrat-Durebex , Samira Osman , Yara Al Ojaimi , Philippe Gosset , Camille Dupuy et al.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2025, 26 (3-4), pp.368-374. ⟨10.1080/21678421.2024.2433578⟩

Article dans une revue hal-04877256v1
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PFMG2025–integrating genomic medicine into the national healthcare system in France

Caroline Abadie , Aldja Abderrahmane , Ouarda Abdous , Carine Abel , Oanez Ackermann et al.

The Lancet Regional Health - Europe, 2025, 50, ⟨10.1016/j.lanepe.2024.101183⟩

Article dans une revue hal-04988732v1
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Intracerebral drug delivery using microbubble/nanodroplet-assisted ultrasound to address neurodegenerative diseases

Karen Ea , Nicolas Taulier , Christiane Contino-Pépin , Wladimir Urbach , Stéphane Desgranges et al.

Journal of Clinical and Translational Research, 2025, pp.00061. ⟨10.36922/jctr.24.00061⟩

Article dans une revue hal-04974610v1
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MAPT mutations in amyotrophic lateral sclerosis: clinical, neuropathological and functional insights

Sibylle de Bertier , Géraldine Lautrette , Maria-Del-Mar Amador , Tomoko Miki , Séverine Boillée et al.

Journal of Neurology, 2025, 272, pp.272. ⟨10.1007/s00415-025-13007-1⟩

Article dans une revue hal-05008980v1
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Pharmacometabolomics applied to low-dose interleukin-2 treatment in amyotrophic lateral sclerosis

Hugo Alarcan , Clément Bruno , Patrick Emond , Cédric Raoul , Patrick Vourc’h et al.

Annals of the New York Academy of Sciences, 2024, 1536 (1), pp.82-91. ⟨10.1111/nyas.15147⟩

Article dans une revue hal-04767126v1
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Microglia Density and Its Association With Disease Duration, Severity, and Orexin Levels in Patients With Narcolepsy Type 1

Lucie Barateau , Anis Krache , Alexandre da Costa , Michel Lecendreux , Rachel Debs et al.

Neurology, 2024, 102 (10), ⟨10.1212/WNL.0000000000209326⟩

Article dans une revue hal-04561871v1

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data

Sara Saez-Atienzar , Cleide dos Santos Souza , Ruth Chia , Selina Beal , Ileana Lorenzini et al.

Cell Genomics, 2024, 4 (11), pp.100679. ⟨10.1016/j.xgen.2024.100679⟩

Article dans une revue hal-04921891v1

N-Terminal Fragments of TDP-43—In Vitro Analysis and Implication in the Pathophysiology of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration

Anna Chami , Léa Bedja-Iacona , Elodie Richard , Debora Lanznaster , Sylviane Marouillat et al.

Genes, 2024, 15 (9), pp.1157. ⟨10.3390/genes15091157⟩

Article dans une revue hal-04755409v1
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PET Study of Microglial Activation in Kleine-Levin Syndrome

Lucie Barateau , Anis Krache , Alexandre da Costa , Michel Lecendreux , Sofiene Chenini et al.

Neurology Neuroimmunology & Neuroinflammation, 2024, 11 (4), pp.e200263. ⟨10.1212/NXI.0000000000200263⟩

Article dans une revue hal-04615146v1

French National Protocol for genetic of amyotrophic lateral sclerosis

P. Corcia , Patrick Vourc’h , E. Bernard , J. Cassereau , P. Codron et al.

Revue Neurologique, 2023, 179 (9), pp.1020-1029. ⟨10.1016/j.neurol.2023.05.005⟩

Article dans une revue hal-04456548v1
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Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1

Shanez Haouari , Christian R Andres , Debora Lanznaster , Sylviane Marouillat , Céline Brulard et al.

International Journal of Molecular Sciences, 2023, 24 (2), pp.1268. ⟨10.3390/ijms24021268⟩

Article dans une revue hal-04541653v1
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Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

Paul Hop , Ramona Zwamborn , Eilis Hannon , Gemma Shireby , Marta Nabais et al.

Science Translational Medicine, 2022, 14 (633), pp.eabj0264. ⟨10.1126/scitranslmed.abj0264⟩

Article dans une revue hal-03939741v1
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Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?

Hugo Alarcan , Yara Al Ojaimi , Debora Lanznaster , Jean-Michel Escoffre , Philippe Corcia et al.

Journal of Personalized Medicine, 2022, 12, pp.1071. ⟨10.3390/jpm12071071⟩

Article dans une revue inserm-03723283v1
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Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

Ahmad Al Khleifat , Alfredo Iacoangeli , Joke van Vugt , Harry Bowles , Matthieu Moisse et al.

npj Genomic Medicine, 2022, 7 (1), pp.8. ⟨10.1038/s41525-021-00267-9⟩

Article dans une revue hal-03939759v1

Reply to the letter from Gazulla et al.

Philippe Corcia , Christian Lunetta , Philippe Couratier , Patrick Vourc’h , Marta Gromicho et al.

European Journal of Neurology, 2022, 29 (1), ⟨10.1111/ene.15134⟩

Article dans une revue hal-03521270v1
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Genes containing hexanucleotide repeats resembling C9ORF72 and expressed in the central nervous system are frequent in the human genome

Patrick Vourc’h , François Wurmser , Céline Brulard , Kevin Mouzat , Sandra Kassem et al.

Neurobiology of Aging, 2021, 97, pp.148.e1 - 148.e7. ⟨10.1016/j.neurobiolaging.2020.07.027⟩

Article dans une revue hal-03493473v1
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Targeting synaptic dysfunction using SINEUP ncRNA enhancer in neurodegenerative diseases

Kathia Zaleta-Rivera , Stefano Espinoza , Roberto F. Delgadillo , Emmanuel Astoul , Sylviane Marouillat et al.

LE STUDIUM Multidisciplinary Journal, 2021, 5, pp.62-69. ⟨10.34846/le-studium.214.02.fr.10-2021⟩

Article dans une revue hal-04198506v1
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The Effect of SMN Gene Dosage on ALS Risk and Disease Severity

Matthieu Moisse , Ramona Zwamborn , Joke Vugt , Rick Spek , Wouter Rheenen et al.

Annals of Neurology, 2021, 89 (4), pp.686-697. ⟨10.1002/ana.26009⟩

Article dans une revue hal-03350820v1

The future of ALS might move towards Genetic Therapy

Philippe Corcia , Philippe Couratier , Patrick Vourc’h

Revue Neurologique, 2021, 177 (6), pp.613-614. ⟨10.1016/j.neurol.2021.01.007⟩

Article dans une revue hal-03332250v1
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Impact of a frequent nearsplice SOD1 variant in Amyotrophic Lateral Sclerosis: optimizing SOD1 genetic screening for gene therapy opportunities

François Muratet , Elisa Teyssou , Aude Chiot , Séverine Boillée , Christian S Lobsiger et al.

Journal of Neurology, Neurosurgery and Psychiatry, 2021, 92 (9), pp.942-949. ⟨10.1136/jnnp-2020-325921⟩

Article dans une revue hal-03353407v1

Familial clustering of primary lateral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum

Philippe Corcia , Christian Lunetta , Philippe Couratier , Patrick Vourc’h , Marta Gromicho et al.

European Journal of Neurology, 2021, 28 (8), pp.2780-2783. ⟨10.1111/ene.14960⟩

Article dans une revue hal-03390641v1
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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen , Rick van der Spek , Mark Bakker , Joke van Vugt , Paul Hop et al.

Nature Genetics, 2021, 53 (12), pp.1636-1648. ⟨10.1038/s41588-021-00973-1⟩

Article dans une revue hal-03939733v1
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Primary Lateral Sclerosis: Clinical, radiological and molecular features

P. Bede , P.-F. Pradat , J. Lope , Patrick Vourc’h , Hélène Blasco et al.

Revue Neurologique, 2021, ⟨10.1016/j.neurol.2021.04.008⟩

Article dans une revue hal-03284185v1

Effect of familial clustering in the genetic screening of 235 French ALS families

Philippe Corcia , William Camu , Celine Brulard , Sylviane Marouillat , Philippe Couratier et al.

Journal of Neurology, Neurosurgery and Psychiatry, 2021, 92 (5), pp.479-484. ⟨10.1136/jnnp-2020-325064⟩

Article dans une revue hal-03369962v1

Pre-symptomatic diagnosis in ALS

P. Corcia , S. Lumbroso , C. Cazeneuve , K. Mouzat , W. Camu et al.

Revue Neurologique, 2020, 176 (3), pp.166-169. ⟨10.1016/j.neurol.2019.07.027⟩

Article dans une revue hal-03351418v1
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ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization

Gijs H P Tazelaar , Steven Boeynaems , Mathias De Decker , Joke J F a Van Vugt , Lindy Kool et al.

Brain Communications, 2020, 2 (2), pp.fcaa064. ⟨10.1093/braincomms/fcaa064⟩

Article dans une revue hal-02991948v1
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The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

Hélène Blasco , C Bessy , L Plantier , A Lefevre , E Piver et al.

Scientific Reports, 2020, 10 (1), pp.16824. ⟨10.1038/s41598-020-73966-5⟩

Article dans une revue inserm-03412059v1

Advances in disease-modifying pharmacotherapies for the treatment of amyotrophic lateral sclerosis

Rudolf Hergesheimer , Débora Lanznaster , Patrick Vourc’h , Christian R Andres , Se Bakkouche et al.

Expert Opinion on Pharmacotherapy, 2020, 21 (9), pp.1103-1110. ⟨10.1080/14656566.2020.1746270⟩

Article dans une revue hal-02869854v1

Ferritin and LDL-cholesterol as biomarkers of fat-free mass loss in ALS

Pierre Jésus , Hélène Blasco , Franck Patin , Salah Eddine Bakkouche , Stéphane Beltran et al.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2019, 20 (5-6), pp.441-444. ⟨10.1080/21678421.2019.1597126⟩

Article dans une revue hal-02363239v1
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The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls

Camille Petillon , Rudolf Hergesheimer , Hervé Puy , Philippe Corcia , Patrick Vourc’h et al.

Frontiers in Neuroscience, 2019, 12, pp.1031. ⟨10.3389/fnins.2018.01031⟩

Article dans une revue hal-02351424v1

LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability

Julie Tastet , Hélène Cuberos , Béatrice Vallée , Annick Toutain , Martine Raynaud et al.

Neuroscience, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩

Article dans une revue istex hal-02067472v1
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Recombinant Intrabodies as Molecular Tools and Potential Therapeutics for Amyotrophic Lateral Sclerosis

Dênis Reis de Assis , Anna Chami , Rudolf Hergesheimer , Judith Halewa , Seyedeh Tayebeh Ahmad Pour et al.

LE STUDIUM Multidisciplinary Journal, 2019, pp.1-7. ⟨10.34846/le-studium.173.02.fr.03-2019⟩

Article dans une revue hal-03218538v1
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The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?

Rudolf C Hergesheimer , Anna A Chami , Denis Reis de Assis , Patrick Vourc’h , Christian Andres et al.

Brain - A Journal of Neurology , 2019, 142 (5), pp.1176-1194. ⟨10.1093/brain/awz078⟩

Article dans une revue hal-02612470v1

Metabo-lipidomics of Fibroblasts and Mitochondrial-Endoplasmic Reticulum Extracts from ALS Patients Shows Alterations in Purine, Pyrimidine, Energetic, and Phospholipid Metabolisms

Charlotte Veyrat-Durebex , Céline Bris , Philippe Codron , Cinzia Bocca , Stephanie Chupin et al.

Molecular Neurobiology, 2019

Article dans une revue hal-02032108v1

C-reactive protein: A promising biomarker in ALS?

Philippe Corcia , Hélène Blasco , C Beltran , Christian R Andres , Patrick Vourc’h et al.

Revue Neurologique, 2018, 174 (3), pp.104-105. ⟨10.1016/j.neurol.2017.07.001⟩

Article dans une revue hal-02051961v1

LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b

Béatrice Vallée , Hélène Cuberos , Michel Doudeau , Fabienne Godin , David Gosset et al.

Biochemical Journal, 2018, 475 (23), pp.3745-3761

Article dans une revue hal-01966439v1

Primary fibroblasts derived from sporadic amyotrophic lateral sclerosis patients do not show ALS cytological lesions

Philippe Codron , Julien Cassereau , Patrick Vourc'H , Charlotte Veyrat-Durebex , Hélène Blasco et al.

Amyotrophic lateral sclerosis & frontotemporal degeneration, 2018, 19 (5-6), pp.446-456. ⟨10.1080/21678421.2018.1431787⟩

Article dans une revue hal-01964500v1
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Changes in glomerular filtration rate and outcomes in patients with atrial fibrillation

Laurent Fauchier , Arnaud Bisson , Nicolas Clementy , Patrick Vourc’h , Denis Angoulvant et al.

American Heart Journal, 2018, 198, pp.39-45. ⟨10.1016/j.ahj.2017.12.017⟩

Article dans une revue hal-03655485v1
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Identification of metabolic pathway disturbances using multimodal metabolomics in autistic disorders in a Middle Eastern population

Sylvie Mavel , Tania Bitar , Patrick Emond , Lydie Nadal-Desbarats , Antoine Lefèvre et al.

Journal of Pharmaceutical and Biomedical Analysis, 2018, 152, pp.57 - 65. ⟨10.1016/j.jpba.2018.01.007⟩

Article dans une revue hal-01826422v1

The combination of four analytical methods to explore skeletal muscle metabolomics: Better coverage of metabolic pathways or a marketing argument?

C. Bruno , F. Patin , C. Bocca , Lydie Nadal-Desbarats , F. Bonnier et al.

Journal of Pharmaceutical and Biomedical Analysis, 2018, 148, pp.273 - 279. ⟨10.1016/j.jpba.2017.10.013⟩

Article dans une revue hal-01655608v1
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Search for RASA1 Variants in Capillary Malformations of the Legs in 113 Children: Results from the French National Paediatric Cohort CONAPE

Annabel Maruani , Marine Durieux-Verde , Juliette Mazereeuw-Hautier , Olivia Boccara , Ludovic Martin et al.

Acta Dermato-Venereologica, 2018, 98 (2), pp.251-255. ⟨10.2340/00015555-2835⟩

Article dans une revue hal-02621329v1

The Metabolic Disturbances of Motoneurons Exposed to Glutamate

Sylvie Mavel , Blandine Madji Hounoum , Hélène Blasco , Emmanuelle Coque , Patrick Vourc’h et al.

Molecular Neurobiology, 2018, ⟨10.1007/s12035-018-0945-8⟩

Article dans une revue hal-01826389v1

Phenotypic and genotypic studies of ALS cases in ALS-SMA families

Philippe Corcia , Patrick Vourc’h , Hélène Blasco , Philippe Couratier , Audrey Dangoumau et al.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2018, 19 (5-6), pp.432-437

Article dans une revue hal-02029592v1

In ALS, a mutation could be worth two steps

Philippe Corcia , Hélène Blasco , S. Beltran , Christian R Andres , Patrick Vourc’h et al.

Revue Neurologique, 2018, 174 (10), pp.669-670

Article dans une revue hal-02025282v1
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Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

Hélène Blasco , Charlotte Veyrat-Durebex , Cinzia Bocca , Franck Patin , Patrick Vourc'H et al.

Scientific Reports, 2017, 7, pp.17652. ⟨10.1038/s41598-017-17389-9⟩

Article dans une revue hal-02104331v1
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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Russell L Mclaughlin , Dick Schijven , Wouter van Rheenen , Kristel R van Eijk , Margaret O’brien et al.

Nature Communications, 2017, 8 (1), pp.14774. ⟨10.1038/ncomms14774⟩

Article dans une revue hal-04423266v1
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Wildtype motoneurons, ALS‐Linked SOD1 mutation and glutamate profoundly modify astrocyte metabolism and lactate shuttling

Blandine Madji Hounoum , Sylvie Mavel , Emmanuelle Coque , Franck Patin , Patrick Vourc’h et al.

Glia, 2017, 65 (4), pp.592 - 605. ⟨10.1002/glia.23114⟩

Article dans une revue hal-04767249v1

Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism

Franck Patin , Philippe Corcia , Patrick Vourc’h , Lydie Nadal-Desbarats , Thomas Baranek et al.

Molecular Neurobiology, 2017, 54 (7), pp.5361-5374. ⟨10.1007/s12035-016-0078-x⟩

Article dans une revue hal-03534393v1

Ductal adenocarcinoma of the prostate: Clinical and biological profiles

Armelle Vinceneux , Franck Bruyere , Olivier Haillot , Thomas Charles , Alexandre de La Taille et al.

Prostate, 2017, 77 (12), pp.1242 - 1250. ⟨10.1002/pros.23383⟩

Article dans une revue hal-01893586v1

SOD1 mutation can mask C9orf72 abnormal expansion

P. Corcia , Hélène Blasco , G. Besson , J.P. Camdessanché , V. Pautot et al.

European Journal of Neurology, 2017, 24 (4), pp.e24 - e24. ⟨10.1111/ene.13257⟩

Article dans une revue hal-01774095v1
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Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Wouter van Rheenen , Aleksey Shatunov , Annelot Dekker , Russell Mclaughlin , Frank Diekstra et al.

Nature Genetics, 2016, 48 (9), pp.1043-1048. ⟨10.1038/ng.3622⟩

Article dans une revue hal-03939751v1

Panel of oxidative stress and inflammatory biomarkers in als: a pilot study

Helene Blasco , Guillaume Garcon , Franck Patin , Charlotte Veyrat-Durebex , Judith Boyer et al.

Canadian Journal of Neurological Sciences, 2016, The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 44 (1), pp.90-95. ⟨10.1017/cjn.2016.284⟩

Article dans une revue hal-03776862v1
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NSC-34 Motor Neuron-Like Cells Are Unsuitable as Experimental Model for Glutamate-Mediated Excitotoxicity

Blandine Madji Hounoum , Patrick Vourc’h , Romain Felix , Philippe Corcia , Franck Patin et al.

Frontiers in Cellular Neuroscience, 2016, 10, pp.118. ⟨10.3389/fncel.2016.00118⟩

Article dans une revue hal-04767258v1

Roles of LIM kinases in central nervous system function and dysfunction

H. Cuberos , B. Vallée , Patrick Vourc’h , J. Tastet , Christian R Andres et al.

FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩

Article dans une revue hal-02072231v1

A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population

Maïté Amy , Oliver Staehlin , Frédérique René , Hélène Blasco , Sylviane Marouillat et al.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2015, 16 (7-8), pp.490--496

Article dans une revue hal-01985793v1

Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism

Julie Tastet , Loïc Decalonne , Sylviane Marouillat , Joëlle Malvy , Rose-Anne Thépault et al.

Psychiatric Genetics, 2015, 25 (6), pp.263-267. ⟨10.1097/ypg.0000000000000100⟩

Article dans une revue hal-02072312v1

Deficits in Information Transfer between Hospital-Based and Primary-Care Physicians, the Case of Kidney Disease: A Cross-Sectional Study

Benedicte Sautenet , Agnès Caille , Bruno Giraudeau , Julie Léger , Patrick Vourc’h et al.

Journal of Nephrology, 2015, 28 (5), pp.563-570. ⟨10.1007/s40620-015-0175-3⟩

Article dans une revue hal-03156122v1

Serum influence on in-vitro gene delivery using microbubble-assisted ultrasound

Aya Zeghimi , Novell Anthony , Rose-Anne Thepault , Patrick Vourc'H , Ayache Bouakaz et al.

Journal of Drug Targeting, 2014, 22 (8), pp.748-760. ⟨10.3109/1061186X.2014.921922⟩

Article dans une revue inserm-02438479v1

A Prospective Study of Estimated Glomerular Filtration Rate and Outcomes in Patients With Atrial Fibrillation

Amitava Banerjee , Laurent Fauchier , Patrick Vourc'H , Christian Andres , Sophie Taillandier et al.

Chest, 2014, 145 (6), pp.1370-1382. ⟨10.1378/chest.13-2103⟩

Article dans une revue hal-03677545v1

Renal Impairment and Ischemic Stroke Risk Assessment in Patients With Atrial Fibrillation

Amitava Banerjee , Laurent Fauchier , Patrick Vourc’h , Christian R Andres , Sophie Taillandier et al.

Journal of the American College of Cardiology, 2013, 61 (20), pp.2079-2087. ⟨10.1016/j.jacc.2013.02.035⟩

Article dans une revue hal-03679433v1

Total protein level in cerebrospinal fluid is stable in elderly adults

Diane Dufour-Rainfray , Emilie Beaufils , Patrick Vourc’h , Emilie Vierron , Laurent Mereghetti et al.

Journal of the American Geriatrics Society, 2013, 61 (10), pp.1819-1821. ⟨10.1111/jgs.12489⟩

Article dans une revue istex hal-02650316v1

Xq27 FRAXA Locus is a Strong Candidate for Dyslexia: Evidence from a Genome-Wide Scan in French Families

M. Huc-Chabrolle , Céline Charon , A. Guilmatre , Patrick Vourc’h , G. Tripi et al.

Behavior Genetics, 2013, 43 (2), pp.132-140. ⟨10.1007/s10519-012-9575-5⟩

Article dans une revue cea-04608759v1
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1H-13C NMR-based urine metabolic profiling in autism spectrum disorders.

Sylvie Mavel , Lydie Nadal-Desbarats , Hélène Blasco , Frédérique Bonnet-Brilhault , Catherine Barthélémy et al.

Talanta, 2013, 114, pp.95-102. ⟨10.1016/j.talanta.2013.03.064⟩

Article dans une revue inserm-00908985v1
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GC-MS-based urine metabolic profiling of autism spectrum disorders.

Patrick Emond , Sylvie Mavel , Nacima Aïdoud , Lydie Nadal-Desbarats , Frédéric Montigny et al.

Analytical and Bioanalytical Chemistry, 2013, 405 (15), pp.5291-300. ⟨10.1007/s00216-013-6934-x⟩

Article dans une revue inserm-00908948v1
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Idiopathic Parkinson's disease phenotype related to C9ORF72 repeat expansions: contribution of the neuropsychological assessment.

Mariam Annan , Émilie Beaufils , Ursule-Catherine Viola , Patrick Vourc’h , Caroline Hommet et al.

BMC Research Notes, 2013, 6 (1), pp.343. ⟨10.1186/1756-0500-6-343⟩

Article dans une revue inserm-00871180v1

Study of the HFE gene common polymorphisms in French patients with sporadic amyotrophic lateral sclerosis.

Julien Praline , Hélène Blasco , Patrick Vourc’h , Valérian Rat , Chantal Gendrot et al.

Journal of the Neurological Sciences, 2012, 317 (1-2), pp.58-61. ⟨10.1016/j.jns.2012.02.029⟩

Article dans une revue istex hal-00927560v1

mRNA-selective translation induced by FSH in primary Sertoli cells

Astrid Musnier , K. Leon , J. Morales , Eric Reiter , Thomas Boulo et al.

Molecular Endocrinology -Baltimore-, 2012, 26 (4), pp.669-680. ⟨10.1210/me.2011-1267⟩

Article dans une revue hal-01129597v1

LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain

Julie Tastet , Patrick Vourc’h , Frédéric Laumonnier , Béatrice Vallée , Carole Michelle et al.

Biochemical and Biophysical Research Communications, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩

Article dans une revue istex hal-01136281v1

The P413L chromogranin B variation in French patients with sporadic amyotrophic lateral sclerosis.

Hélène Blasco , Philippe Corcia , Charlotte Veyrat-Durebex , Cathleen Coutadeur , Clémentine Fournier et al.

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2011, 12 (3), pp.210-4. ⟨10.3109/17482968.2010.522587⟩

Article dans une revue hal-00926892v1

Association between divalent metal transport 1 encoding gene (SLC11A2) and disease duration in amyotrophic lateral sclerosis.

Hélène Blasco , Patrick Vourc’h , Yann Nadjar , Bénédicte Ribourtout , Paul H Gordon et al.

Journal of the Neurological Sciences, 2011, 303 (1-2), pp.124-7. ⟨10.1016/j.jns.2010.12.018⟩

Article dans une revue istex hal-00926903v1
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Respiratory onset in an ALS family with L144F SOD1mutation

Philippe Corcia , Philippe Petiot , Zorica Stevic , Patrick Vourc’h , Raoul Morales et al.

Journal of Neurology, Neurosurgery and Psychiatry, 2010, 82 (7), pp.747. ⟨10.1136/jnnp.2009.197558⟩

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Study of the serotonin transporter (SLC6A4) and BDNF genes in French patients with non syndromic mental deficiency.

Refaat Tabagh , Christian R Andres , Sylviane Védrine , Catherine Cherpi-Antar , Rose-Anne Thepault et al.

BMC Medical Genetics, 2010, 11 (1), pp.30. ⟨10.1186/1471-2350-11-30⟩

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Association study of the ubiquitin conjugating enzyme gene UBE2H in sporadic ALS.

Isabelle Martin , Patrick Vourc’h , Marie Mahé , Rose-Anne Thépault , Catherine Antar et al.

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 2009, 10 (5-6), pp.432-5. ⟨10.3109/17482960802444972⟩

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Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells

Isabelle Martin , Christian Andres , Sylviane Védrine , Refaat Tabagh , Caroline Michelle et al.

Brain Research, 2009, 1284, pp.22-30. ⟨10.1016/j.brainres.2009.05.070⟩

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Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.

Agathe Paubel , Jeremy Violette , Maïté Amy , Julien Praline , Vincent Meininger et al.

Archives of Neurology -Chigago-, 2008, 65 (10), pp.1333-6. ⟨10.1001/archneur.65.10.1333⟩

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Exclusion of the coding sequence of the doublecortin gene as a susceptibility locus in autistic disorder

Patrick Vourc'H , Elisabeth Petit-Teixeira , Jean Pierre Müh , Christian Andres , Thierry Bienvenu et al.

American Journal of Medical Genetics, 2002, 108 (2), pp.164-167. ⟨10.1002/ajmg.10210⟩

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No mutations in the coding region of the Rett syndrome gene MECP2 in 59 autistic patients

Patrick Vourc'H , Thierry Bienvenu , Cherif Beldjord , Jamel Chelly , Catherine Barthélémy et al.

European Journal of Human Genetics, 2001, 9 (7), pp.556-558. ⟨10.1038/sj.ejhg.5200660⟩

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LIM kinases are promising therapeutic targets: from the development of small molecule inhibitors targeting these kinases to preclinical validation on different mouse models.

Béatrice Vallée , Rayan Berabez , Anthony Champiré , Régis Brion , Abdennour Braka et al.

47th FEBS Congress, Jul 2023, Tours (FR), France

Poster de conférence hal-04906944v1

Molecular and functional characterization of LIMK2-1, a hominidae-specific isoform of LIMK2 associated with intellectual disability

H. Bénédetti , Béatrice Vallée , J. Tastet , H. Cubéros , A. Toutain et al.

NeuroFrance 2019, May 2019, Marseille, France

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LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1

A. Champiré , A. Braka , B. Vallée , M. Doudeau , F. Godin et al.

VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria

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LIM kinases: new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , Michel Doudeau , Fabienne Godin , Anthony Champiré , Karen Plé et al.

The 7th EMBO meeting, Sep 2016, Mannheim, Germany.

Poster de conférence hal-02453490v1

The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways

Béatrice Vallée , Hélène Cuberos , Michel Doudeau , Fabienne Godin , Patrick Vourc’h et al.

EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany.

Poster de conférence hal-02453489v1

LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability

Béatrice Vallée , Hélène Cuberos , Julie Tastet , Michel Doudeau , Fabienne Godin et al.

10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark.

Poster de conférence hal-02453486v1

LIMK2 (LIM kinase2) isoforms are differentially expressed during neuronal differentiation

J. Tastet , P. Vourc'H , F. Laumonnier , C. Michelle , Anne Duittoz et al.

7. FENS Forum of European Neuroscience, Jul 2010, Amsterdam, Netherlands. n.p., 2010

Poster de conférence hal-02818145v1

Corrélations entre les paramètres biologiques et la composition corporelle dans la sclérose latérale amyotrophique

Pierre Jésus , F Patin , S.E. Bakkouche , S. Beltran , C.R. Andres et al.

Journées Francophones de Nutrition (JFN), Société Française de Nutrition (SFN) et la Société Francophone de Nutrition Clinique et Métabolisme (SFNEP), Nov 2018, Nice, France. pp.64

Communication dans un congrès hal-02365870v1

Dynamic hormonal control of mRNA translation

Kelly León , Astrid Musnier , Thomas Boulo , Gwenhael Jegot , Sophie Tesseraud et al.

GDR 3545: RCPG-Physio-Med, Centre National de la Recherche Scientifique (CNRS). Paris, FRA., Oct 2013, Paris, France. 1 p

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Dynamique du contrôle hormonal de la traduction des ARNm

Kelly León , Astrid Musnier , Thomas Boulo , Sophie Tesseraud , Vlad Costache et al.

25. Colloque Biotechnocentre, Association pour le Développement des Biotechnologies en Région Centre (Biotechnocentre). Tours, FRA., Oct 2012, Seillac, France

Communication dans un congrès hal-02748238v1

Effect of the oligodendrocyte myelin glycoprotein (OMgp) on the expansion and neuronal differentiation of rat neural stem cells

I. Martin , Charles Andres , S. Védrine , Tabagh Refaat , Michelle Caroline et al.

9. Colloque de la Société des Neurosciences, May 2009, Bordeaux, France. n.p., ⟨10.1016/j.brainres.2009.05.070⟩

Communication dans un congrès istex hal-02819790v1

Expression des isoformes de LIM Kinase 2 pendant la neurogenèse et la stimulation des neurones

J. Tastet , P. Vourc'H , F. Laumonnier , C. Michelle , Anne Duittoz et al.

22. Colloque Biotechnocentre, Oct 2009, Seillac, France

Communication dans un congrès hal-02753426v1

Inhibition of neural precursor cell proliferation by the oligodendrocyte myelin glycoprotein (OMgp)

P. Vourc'H , I. Martin , S. Védrine , M. Amy , P. Corcia et al.

8. Colloque de la Société des Neurosciences, May 2007, Montpellier, France. n.p

Communication dans un congrès hal-02819833v1