Pierre LEBLOND
Pierre Leblond
138
Documents
Current affiliations
Researcher identifiers
- pierre-leblond
- 0000-0002-8703-454X
- IdRef : 074217127
Presentation
**Bio**
I received my PhD in molecular genetics in 1990 under the supervision of Prof. Bernard Decaris at Université Henri Poincaré in Nancy. Then, I did my military service (1 yr) as a scientist in the lab of Profs. I. Gresser and M. Tovey at Hôpital Paul Brousse (CNRS, Villejuif). Afterwards, I joined for 2 years Pr. J. Cullum at Kaiserslautern (Germany) thanks to EMBO and European Community fellowships. I was appointed to the position of Maître de Conférences at Université Henri Poincaré and was granted a professorship in 1995. Since then, I lead a research team; today named *Streptomyces Adaptation*, StrAda.
In the past, I was director of the research unit from 2007 to 2018 (co-director from 2001 to 2007). At the national level, I sat at the National University Committee (CNU 65, cellular biology, 3 terms between 2004 and 2018). I sat in several instances of the Université de Lorraine (executive board, cluster council, faculty council). I was vice-president UL in charge of technology transfer in 2017-18, and currently project manager for the construction of a research building at the Faculty of Sciences.
**Research**
The guiding thread of all my research is to better understand the molecular mechanisms of bacterial genome evolution. Early in my career, I met *Streptomyces* and it became my pet bacteria. I developed methods (pulsed-field gel electrophoresis) and applied approaches (genome mapping, comparative genomics, genome mining) to study genome structure, organization and dynamics. Notably, I focused on recombination mechanisms shaping the genome (homologous and illegitimate recombination). Hence, these soil bacteria have to face variable environmental (biotic and abiotic parameters) conditions. They show an extraordinary capacity to adapt and to evolve through horizontal gene transfer. We currently study this dynamic in natural populations of *Streptomyces* (isolated from grains of forest soil) in terms of acquisition and diversification of new genes (secondary metabolite gene clusters, nutriment utilization, mobile genetic elements).
**Teaching**
I am teaching since 1989 in the field of genetics and microbiology in undergraduate and graduate courses. I continuously managed University programs; from 1995 to 2018 Licence de Biologie, Maîtrise de Génétique Moléculaire et Cellulaire, DESS Ressources Génomiques et Traitements Informatiques, Master de Microbiologie, Master Biotechnologies, Microbiologie, Aliment, Nutrition ; and founded several of them: DESS RGTI (2001), Master de Microbiologie (2008). I also contributed to the creation of the Cursus Master of Engineering (CMI ‘Biologie Santé Environnement’) in 2010 and supervised the cursus at its opening in 2012. Since 2018, I supervise the RIM (Research in Microbiology) orientation of the Master Microbiology (M2), a project-driven course in the omics field with full immersion in research laboratories.
**Contact**
E-mail : <pierre.leblond@univ-lorraine.fr>
Téléphone : +33 (0)3 72 74 51 43
IdeHAL **pierre-leblond**
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Nonhomologous End-Joining in BacteriaJoseph Jez. Encyclopedia of Biological Chemistry 3rd Edition,, 4, Elsevier, 2021, 9780128194607
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Evolution Underway in ProkaryotesSébastien Wielgoss; Pierre Leblond; Catherine Masson-Boivin; Philippe Normand. Prokaryotes and Evolution, Springer International Publishing, pp.339-391, 2019, 978-3-319-99784-1. ⟨10.1007/978-3-319-99784-1_6⟩
Book sections
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Subtelomere Plasticity in the Bacterium StreptomycesEdward J Louis, Marion M Becker. Subtelomeres, Springer Berlin Heidelberg, pp.243-258, 2013, 978-3-642-41565-4. ⟨10.1007/978-3-642-41566-1_14⟩
Book sections
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Genome-guided Exploration of Streptomyces ambofaciens Secondary MetabolismPaul J Dyson Institute of Life Sciences, School of Medicine, Swansea, UK. Streptomyces: Molecular Biology and Biotechnology, Caister Academic Press, Chapter 10 pp. 179-194, 2011, 978-1-904455-77-6
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Using Markov Models to Mine Temporal and Spatial DataKimito Funatsu and Kiyoshi Hasegawa. New Fundamental Technologies in Data Mining, Intech, pp.561--584, 2011, 978-953-307-547-1
Book sections
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Fouille de données du génome à l'aide de modèles de Markov cachésExtraction et gestion des connaissances. EGC 2005, Cépaduès, 2005, Revue des Nouvelles Technologies de l'Information, 2-85428-677-4 2-85428-682-0 (vol. 1) 2-85428-683-9 (vol. 2)
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PFGE: électrophorèse en champs pulsés (pulse field electrophoresis)INRA. Principes des techniques de biologie moléculaire, INRA Editions, pp.152-153, 2004, 9782738010674
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Unstable Linear Chromosomes: the Case of StreptomycesRobert L Charlebois. Organization of the prokaryotic genome, ASM Press, pp.235-262, 1999, 1-55581-151-5
Book sections
hal-01659748v1
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Biosenseur bactérien de la dégradation du boisFrance, N° de brevet: WO2016131665. 2016
Patents
hal-01655306v1
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Stambomycin and derivatives: their production and their use as drugsFrance, Patent n° : WO2011009938. 2011
Patents
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La folle course aux armements des bactéries contre les antibiotiques2018
Other publications
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Ne me cassez pas les chromosomes !2018
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Activation of cryptic biosynthetic pathways by bacterial/fungal co-culturesBiomolecules: Research & Development, Markets and Acceptability - LUE Impact Biomolecule seminar, Oct 2019, Palma de Mallorca, Spain
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Massive gene flux in bacterial population fuels adaptation to forest soil ecosystem15ème congrès de la Société Française de Microbiologie, Sep 2019, Paris 19ème, France. 2019
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Bacteria/fungi Interactions (BFI): a way to awake secondary metabolite gene clustersLorraine Université d'Excellence (LUE) Séminaire Impact Biomolécules, May 2018, Nancy, France
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Deciphering and exploiting bacteria-fungi dialogues to identify new bioactive metabolites12èmes Rencontres de Phytopathologie - Mycologie de la Société Française de Phytopathologie, Jan 2018, Aussois, France
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Interplay between lateral gene transfer and rhizosphere functioningFunctional ecology conference 2018, Dec 2018, Nancy, France
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Searching for novel specialized metabolite gene clusters, a new comparative genomics-based approachDirecting Biosynthesis V, Mar 2017, Warwick, United Kingdom
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Dynamics and maintenance of ICEs from Streptococcus thermophilusFEMS 2011, Jun 2011, Geneva, Switzerland
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Etude de la régulation du transfert d'éléments intégratifs conjugatifs chez Streptococcus thermophilus16éme colloque du Club des Bactéries Lactiques, May 2009, Toulouse, France
Conference poster
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Data Mining Using Hidden Markov Models (HMM2) to Detect Heterogeneities into Bacteria Genomes6. Journées Ouvertes Biologie, Informatique et Mathématiques - JOBIM, Jul 2005, Lyon, France. , 1 p., 2005
Conference poster
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Evidence for a High Heterogeneity Between the Terminal Regions of the Chromosomes of Two Phylogenetically Close Species, Streptomyces ambofaciens and Streptomyces coelicolor by Genome ComparisonStreptomyces dissemination meeting, Jul 2003, Guilford, United Kingdom. 2003, Streptomyces dissemination meeting
Conference poster
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