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A consensus protocol for functional connectivity analysis in the rat brain
Joanes Grandjean
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Article dans une revue
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A revisited version of the disputatio for pharmacological training: An educational study
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[18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans
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Matthieu Colom
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Didier Le Bars
Article dans une revue
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Positron Emission Tomography for the Discovery of New Drugs in Psychiatry
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Article dans une revue
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Anti-CD20 therapies in multiple sclerosis: From pathology to the clinic
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Article dans une revue
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Single subanesthetic dose of ketamine produces delayed impact on brain [18F]FDG PET imaging and metabolic connectivity in rats
Sarah Chaib
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Caroline Bouillot
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Sandrine Bouvard
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Benjamin Vidal
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Luc Zimmer
Article dans une revue
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PET metabolic imaging of time-dependent reorganization of olfactory cued fear memory networks in rats
Anne-Marie Mouly
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Caroline Bouillot
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Nicolas Costes
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Luc Zimmer
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Nadine Ravel
Article dans une revue
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Different alterations of agonist and antagonist binding to 5-HT1A receptor in a rat model of Parkinson's disease and levodopa-induced dyskinesia : a microPET study
Benjamin Vidal
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Elise Levigoureux
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Sarah Chaib
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Caroline Bouillot
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Thierry Billard
Article dans une revue
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[18F]F13640, a 5-HT1A Receptor Radiopharmaceutical Sensitive to Brain Serotonin Fluctuations
Matthieu Colom
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Benjamin Vidal
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Sylvain Fieux
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Jérôme Redoute
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Nicolas Costes
Article dans une revue
hal-03407570v1
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PET metabolic imaging of time-dependent reorganization of olfactory cued fear memory networks in rats
Anne-Marie Mouly
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Caroline Bouillot
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Nicolas Costes
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Luc Zimmer
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Nadine Ravel
Cerebral Cortex, In press
Article dans une revue
hal-03358716v1
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Towards in vivo imaging of functionally active 5-HT1A receptors in schizophrenia: concepts and challenges
Oriane Razakarivony
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Adrian Newman-Tancredi
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Luc Zimmer
Article dans une revue
hal-03160747v1
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Clinical research in psychopharmacology, the current situation and its perspectives. A conversation with Pierre-Michel Llorca
Pierre-Michel Llorca
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Luc Zimmer
Article dans une revue
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Innovative approaches in CNS drug discovery
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Vincent Lafon
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Franck Mouthon
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Luc Zimmer
Article dans une revue
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Functional ultrasound imaging to study brain dynamics: Application of pharmaco-fUS to atomoxetine
Benjamin Vidal
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Marine Droguerre
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Ludovic Venet
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Luc Zimmer
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Marco Valdebenito
Article dans une revue
hal-03160725v1
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Preclinical validation of [18F]2FNQ1P as a specific PET radiotracer of 5-HT6 receptors in rat, pig, non-human primate and human brain tissue
Stéphane Emery
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Sylvain Fieux
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Benjamin Vidal
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Pierre Courault
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Article dans une revue
hal-03035781v1
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Pharmaco-fUS for Characterizing Drugs for Alzheimer’s Disease – The Case of THN201, a Drug Combination of Donepezil Plus Mefloquine
Benjamin Vidal
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Marine Droguerre
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Marco Valdebenito
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Luc Zimmer
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Michel Hamon
Article dans une revue
hal-03160675v1
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Bayesian Estimation of the ntPET Model in Single-Scan Competition PET Studies
Zacharie Irace
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Inés Mérida
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Jérôme Redouté
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Clara Fonteneau
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Marie-Françoise Suaud-Chagny
Article dans une revue
hal-03160651v1
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Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer’s Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P
Pierre Courault
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Stéphane Emery
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Sandrine Bouvard
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François Liger
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Fabien Chauveau
Article dans une revue
hal-03035778v1
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18F-F13640 PET imaging of functional receptors in humans
Matthieu Colom
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Nicolas Costes
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Jerome Redoute
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Frédéric Dailler
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Florent Gobert
Article dans une revue
hal-02305453v1
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Pharmacological MRI to investigate the functional selectivity of 5-HT1A receptor biased agonists
Benjamin Vidal
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Radu Bolbos
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Jérôme Redouté
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Jean-Baptiste Langlois
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Nicolas Costes
Article dans une revue
hal-03490240v1
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Sécurisation de la prise en charge médicamenteuse des patients sous antipsychotiques : impact de la collaboration médico-pharmaceutique à la Maison d’Arrêt de Lyon-Corbas
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Article dans une revue
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Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!
Min Zhang
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Caroline Bouillot
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Radu Bolbos
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Jean-Baptiste Langlois
Article dans une revue
hal-02278818v1
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MAPSSIC, a Novel CMOS Intracerebral Positrons Probe for Deep Brain Imaging in Awake and Freely Moving Rats: A Monte Carlo Study
L. Ammour
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Article dans une revue
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Serotonin 5-HT 1A Receptor Biased Agonists Induce Different Cerebral Metabolic Responses: A [ 18 F]-Fluorodesoxyglucose Positron Emission Tomography Study in Conscious and Anesthetized Rats
Elise Levigoureux
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Benjamin Vidal
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Sylvain Fieux
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Caroline Bouillot
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Stéphane Emery
Article dans une revue
hal-02305418v1
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PET imaging of the influence of physiological and pathological α‐synuclein on dopaminergic and serotonergic neurotransmission in mouse models
Elise Levigoureux
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Caroline Bouillot
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Thierry Baron
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Luc Zimmer
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Sophie Lancelot
Article dans une revue
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Is there a Role for Agonist Radiopharmaceuticals in PET Neuroimaging?
Matthieu Colom
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Zimmer Luc
Article dans une revue
hal-02310324v1
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Meta-analysis in metastatic uveal melanoma to determine progression free and overall survival benchmarks: an international rare cancers initiative (IRCI) ocular melanoma study
L Khoja
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E. G. Atenafu
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Article dans une revue
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Evaluation of [ 18 F]2FP3 in pigs and non-human primates
Hanne Hansen
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Olivier Barret
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Matthias Herth
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Janus Magnussen
Journal of Labelled Compounds and Radiopharmaceuticals, 2019, 62 (1), pp.34-42. ⟨10.1002/jlcr.3692⟩
Article dans une revue
hal-02109621v1
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Amyloid-beta radiotracer [ 18 F]BF-227 does not bind to cytoplasmic glial inclusions of post-mortem Multiple System Atrophy brain tissue
Mathieu Verdurand
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Elise Levigoureux
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Sophie Lancelot
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Waël Zeinyeh
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Thierry Billard
Article dans une revue
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In Silico, in Vitro, and in Vivo Evaluation of New Candidates for α-Synuclein PET Imaging
Mathieu Verdurand
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Elise Levigoureux
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Wael Zeinyeh
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Laurent Berthier
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Meriem Mendjel-Herda
Molecular Pharmaceutics, 2018, 15 (8), pp.3153-3166
Article dans une revue
hal-01955442v1
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18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging
Benjamin Vidal
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Sylvain Fieux
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Matthieu Colom
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Thierry Billard
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Caroline Bouillot
Article dans une revue
hal-02107028v1
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Implantable CMOS pixel sensor for positron imaging in rat brain
J. Heymes
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L. Ammour
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M. Bautista
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Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2018, 911, pp.19-24. ⟨10.1016/j.nima.2018.09.117⟩
Article dans une revue
hal-01952201v1
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In vivo biased agonism at 5-HT1A receptors: characterisation by simultaneous PET/MR imaging
Benjamin Vidal
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Sylvain Fieux
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Jerome Redoute
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Marjorie Villien
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Frédéric Bonnefoi
Article dans une revue
hal-01917722v1
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Ozone Atmospheric Pollution and Alzheimer’s Disease: From Epidemiological Facts to Molecular Mechanisms
Marine L. Croze
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Luc Zimmer
Article dans une revue
hal-01785212v1
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Activity in the rat olfactory cortex is correlated with behavioral response to odor: a microPET study
Philippe Litaudon
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Caroline Bouillot
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Luc Zimmer
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Nicolas Costes
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Nadine Ravel
Article dans une revue
hal-03772857v1
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Hippocampal 5-HT 1A receptor expression changes in prodromal stages of Alzheimer's disease: Beneficial or deleterious?
Mathieu Verdurand
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Luc Zimmer
Article dans une revue
hal-01689706v1
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Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [ 11 C]-( R )-PK11195 PET and MRI
J. Yankam-Njiwa
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N. Costes
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C. Bouillot
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S. Bouvard
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S. Fieux
Article dans une revue
hal-01571316v1
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Contribution of Clinical Neuroimaging to the Understanding of the Pharmacology of Methylphenidate
Luc Zimmer
Article dans une revue
hal-01689783v1
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Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors
Véronique Sgambato-Faure
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Thierry Billard
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Elise Metereau
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Sandra Duperrier
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Sylvain Fieux
Article dans une revue
hal-01689720v1
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[ 11 C]PF-3274167 as a PET radiotracer of oxytocin receptors: Radiosynthesis and evaluation in rat brain
Benjamin Vidal
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Iuliia Karpenko
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François Liger
,
Sylvain Fieux
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Caroline Bouillot
Article dans une revue
hal-01689748v1
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Activity in the rat olfactory cortex is correlated with behavioral response to odor: a microPET study
Philippe Litaudon
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Caroline Bouillot
,
Luc Zimmer
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Nicolas Costes
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Nadine Ravel
Article dans une revue
hal-03773095v1
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The in Vitro Actions of Loxapine on Dopaminergic and Serotonergic Receptors. Time to Consider Atypical Classification of This Antipsychotic Drug?
Florian Ferreri
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Dominique Drapier
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Emmanuelle Baloche
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Mehemed Ouzid
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Luc Zimmer
Article dans une revue
hal-01696767v1
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Activity in the rat olfactory cortex is correlated with behavioral response to odor: a microPET study
Philippe Litaudon
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Caroline Bouillot
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Luc Zimmer
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Nicolas Costes
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Nadine Ravel
Article dans une revue
hal-02104688v1
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Marmoset Serotonin 5-HT 1A Receptor Mapping with a Biased Agonist PET Probe 18 F-F13714: Comparison with an Antagonist Tracer 18 F-MPPF in Awake and Anesthetized States
Chihiro Yokoyama
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Aya Mawatari
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Akihiro Kawasaki
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Chiho Takeda
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Kayo Onoe
Article dans une revue
hal-01488155v1
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A microPET comparison of the effects of etifoxine and diazepam on [11C]flumazenil uptake in rat brains
Caroline Bouillot
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Frédéric Bonnefoi
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François Liger
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Luc Zimmer
Article dans une revue
hal-01264750v1
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Imaging Dopamine and Serotonin Systems on MPTP Monkeys: A Longitudinal PET Investigation of Compensatory Mechanisms
Benedicte Ballanger
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Maude Beaudoin-Gobert
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Sara Neumane
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Justine Epinat
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Elise Météreau
Article dans une revue
hal-02115078v1
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Pharmacological agonists for more-targeted CNS radio-pharmaceuticals
Luc Zimmer
Article dans une revue
hal-01488034v1
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Imaging Dopamine and Serotonin Systems on MPTP Monkeys: A Longitudinal PET Investigation of Compensatory Mechanisms
Bénédicte Ballanger
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Maude Beaudoin-Gobert
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Sara Neumane
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Justine Epinat
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Elise Metereau
Article dans une revue
hal-01571297v1
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Selective serotonin 5-HT1A receptor biased agonists elicit distinct brain activation patterns: a pharmacoMRI study
G. Becker
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R. Bolbos
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N. Costes
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J. Redouté
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A. Newman-Tancredi
Article dans une revue
hal-01488190v1
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Differential effects of amyloid-beta 1–40 and 1–42 fibrils on 5-HT1A serotonin receptors in rat brain
Mathieu Verdurand
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Fabien Chauveau
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Alexia Daoust Daoust
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Anne-Laure Morel
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Frédéric Bonnefoi
Article dans une revue
hal-01291764v1
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PIXSIC, a Pixelated β(+)-Sensitive Probe for Radiopharmacological Investigations in Rat Brain: Binding Studies with [(18)F]MPPF.
Laure Balasse
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Julia Maerk
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Frédéric Pain
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Aurélie Genoux
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Sylvain Fieux
Article dans une revue
hal-01105052v1
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Selective trifluoromethylthiolation of heteroaromatic sp2 C-H bonds with the 2nd generation of trifluoromethanesulfenamide reagent
Alazet Sébastien
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Zimmer Luc
,
Billard Thierry
Journal of Fluorine Chemistry, 2015, 171, pp.78-81
Article dans une revue
hal-01152905v1
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PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats
Laure Balasse
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Julia Maerk
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Frédéric Pain
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Aurélie Genoux
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Sylvain Fieux
Article dans une revue
in2p3-01235714v1
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Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging
Guillaume Becker
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Julie Colomb
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Véronique Sgambato-Faure
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Léon Tremblay
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Thierry Billard
Article dans une revue
hal-01128421v1
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A Postmortem Study to Compare Agonist and Antagonist 5-HT1A Receptor-binding Sites in Alzheimer's Disease
Guillaume Becker
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Nathalie Streichenberger
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Thierry Billard
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Adrian Newman-Tancredi
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Luc Zimmer
Article dans une revue
hal-01128433v1
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Binding of the PET Radiotracer [18F]BF227 Does not Reflect the Presence of Alpha-Synuclein Aggregates in Transgenic Mice
Elise Levigoureux
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Sophie Lancelot
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Caroline Bouillot
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Fabien Chauveau
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Mathieu Verdurand
Article dans une revue
hal-01128444v1
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Electrophilic trifluoromethylthiolation of carbonyl compounds
Alazet Sébastien
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Zimmer Luc
,
Billard Thierry
Chemistry - A European Journal, 2014, 20 (28), pp.8589-8593
Article dans une revue
hal-01151171v1
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PET radiotracers for molecular imaging of serotonin 5-HT1A receptors
T. Billard
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D. Le Bars
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L. Zimmer
Article dans une revue
hal-00947714v1
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Syntheses, radiolabelings and in vitro evaluations of fluorinated PET radioligands of 5-HT6 serotoninergic receptors.
Julie Colomb
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Guillaume Becker
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Sylvain Fieux
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Luc Zimmer
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And Thierry Billard
Journal of Medicinal Chemistry, 2014, 57, pp.3884-90
Article dans une revue
hal-01309560v1
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A Multi-Atlas Based Method for Automated Anatomical Rat Brain MRI Segmentation and Extraction of PET Activity
Sophie Lancelot
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Roxane Roche
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Afifa Slimen
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Caroline Bouillot
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Elise Levigoureux
Article dans une revue
hal-01128452v1
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Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase
Emilie da Costa Branquinho
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Guillaume Becker
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Cédric Bouteiller
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Ludovic Jean
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Pierre-Yves Renard
Article dans une revue
hal-00847401v1
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Outcome of Poor-Grade Subarachnoid Hemorrhage as Determined by Biomarkers of Glucose Cerebral Metabolism
G.K. Barcelos
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Y. Tholance
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S. Grousson
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B. Renaud
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A. Perret-Liaudet
Article dans une revue
hal-00847412v1
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Ultra high performance liquid chromatography as a tool for the discovery and the analysis of biomarkers of diseases: A review
L. Denoroy
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L. Zimmer
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B. Renaud
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S. Parrot
Article dans une revue
hal-00847427v1
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A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats
Julia Maerk
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Didier Benoit
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Laure Balasse
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Mathieu Benoit
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Jean-Claude Clémens
Article dans une revue
in2p3-00837658v1
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Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes
S. Alazet
,
L. Zimmer
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T. Billard
Article dans une revue
hal-00948085v1
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Current status of positron emission tomography radiotracers for serotonin receptors in humans
L. Zimmer
,
D. Le Bars
Journal of Labelled Compounds and Radiopharmaceuticals, 2013, 56 (3-4), pp.105-113. ⟨10.1002/jlcr.3001⟩
Article dans une revue
hal-00828326v1
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Enhanced Anxiety Observed in Cocaine Withdrawn Rats Is Associated with Altered Reactivity of the Dorsomedial Prefrontal Cortex
Cynthia El Hage
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Virginie Rappeneau
,
Adeline Etiévant
,
Anne-Laure Morel
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Hélène Scarna
Article dans une revue
hal-03630188v1
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MicroPET imaging of 5-HT1A receptors in rat brain: a test-retest [18F]MPPF study
N. Aznavour
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C. Benkelfat
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P. Gravel
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A. Aliaga
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P. Rosa-Neto
Article dans une revue
hal-00847462v1
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Behaviour of a genetic mouse model of depression in the learned helplessness paradigm
Laure Bougarel
,
Jérôme Guitton
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Luc Zimmer
,
Jean-Marie Vaugeois
,
Malika El Yacoubi
Article dans une revue
hal-02185484v1
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Genetic Inactivation of Prokineticin Receptor-1 Leads to Heart and Kidney Disorders
Mounia Boulberdaa
,
Gulen Turkeri
,
Kyoji Urayama
,
Mojdeh Dormishian
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Cécilia Szatkowski
Article dans une revue
hal-02391087v1
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Genetic association between helpless trait and depression-related phenotypes: evidence from crossbreeding studies with H/Rouen and NH/Rouen mice.
Malika El Yacoubi
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Daniela Popa
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Benoît Martin
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Luc Zimmer
,
Michel Hamon
Article dans une revue
hal-00904261v1
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[18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging.
Laëtitia Lemoine
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Mathieu Verdurand
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Bernard Vacher
,
Elodie Blanc
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Didier Le Bars
Article dans une revue
hal-00475580v1
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Effects of amyloid-beta peptides on the serotoninergic 5-HT(1A) receptors in the rat hippocampus.
Mathieu Verdurand
,
Anne Bérod
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Didier Le Bars
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Luc Zimmer
Article dans une revue
hal-00397792v1
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F15063, a potential antipsychotic with dopamine D2/D3 receptor antagonist, 5-HT1A receptor agonist and dopamine D4 receptor partial agonist properties: Influence on neuronal firing and neurotransmitter release
Marie-Bernadette Assié
,
Ouissame Mnie-Filali
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Véronique Ravailhe
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Christelle Benas
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Marc Marien
Article dans une revue
hal-04303724v1
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A distinct [18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease
L. Truchot
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N. Costes
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L. Zimmer
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B. Laurent
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D. Le Bars
NeuroImage, 2008, 15 (40), pp.(1251-6)
Article dans une revue
hal-00443483v1
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The potential of a radiosensitive intracerebral probe to monitor 18F-MPPF binding in mouse hippocampus in vivo
A. Desbrée
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M. Verdurand
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J. Godart
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André Dubois
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R. Mastrippolito
Article dans une revue
hal-03002294v1
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Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment
L. Truchot
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N. Costes
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L. Zimmer
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B. Laurent
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D. Le Bars
Neurology, 2007, 69 (10), pp.(1012-7)
Article dans une revue
hal-00443482v1
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Simultaneous in vivo magnetic resonance imaging and radioactive measurements with the β-MicroProbe
A. Desbrée
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L. Rbah
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J.-B. Langlois
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D. Grenier
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R. Mastrippolito
Article dans une revue
hal-03015570v1
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Simultaneous in vivo Magnetic Resonance Imaging and Radioactive Measurements by the B-MicroProbe
A. Desbrée
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L. Rbah
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J. B. Langlois
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D. Grenier
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R. Mastrippolito
European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34 (11), pp.1868-72
Article dans une revue
hal-00443228v1
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Raytest ClearPET, a new generation small animal PET scanner
Pablo Sempere Roldan
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Emmanuel Chereul
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Oliver Dietzel
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Luc Magnier
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Christian Pautrot
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007, 571 (1-2), pp.498-501. ⟨10.1016/j.nima.2006.10.143⟩
Article dans une revue
hal-00443461v1
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A new multimodality system for quantitative in vivo studies in small animals: combination of nuclear magnetic resonance and the radiosensitive$\beta$-MicroProbe
A. Desbree
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Frederic Pain
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H. Gurden
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L. Pinot
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D. Grenier
Article dans une revue
in2p3-00025341v1
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A new multimodality system for quantitative in vivo studies in small animals: combination of nuclear magnetic resonance and the radiosensitive beta-MicroProbe
E. A. Desbré
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Frederic Pain
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H. Gurden
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L. Pinot
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D. Grenier
IEEE Transactions on Nuclear Science, 2005, 52 (5), pp.1281-1287
Article dans une revue
hal-00443227v1
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Combining the radiosensitive Beta MicroProbe to Nuclear Magnetic Resonance: theoretical approach for in vivo studies in small animals
A. Desbrée
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Frederic Pain
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H. Gurden
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L. Zimmer
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L. Pinot
Article dans une revue
in2p3-00025780v1
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The ANIMAGE project: a multimodal imaging platform for small animal research
D. Sappey-Marinier
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O. Beuf
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C. Billotey
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E. Chereul
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J. Dupuy
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2004, 527, pp.117-123. ⟨10.1016/j.nima.2004.03.092⟩
Article dans une revue
hal-01883295v1
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Displacement of the PET ligand18F-MPPF by the electrically evoked serotonin release in the rat hippocampus
Latifa Rbah
,
Vincent Leviel
,
Luc Zimmer
Article dans une revue
inserm-02437128v1
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The potential of the β-Microprobe, an intracerebral radiosensitive probe, to monitor the [18F]MPPF binding in the rat dorsal raphe nucleus
L. Zimmer
,
Frederic Pain
,
G. Mauger
,
A. Plenevaux
,
D. Le Bars
Article dans une revue
in2p3-00023833v1
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Neither the density nor function of striatal dopamine transporters were influenced by chronic n-3 polyunsaturated fatty acid deficiency in rodents
Ercem Kodas
,
Guylène Page
,
Luc Zimmer
,
Sylvie Vancassel
,
Denis Guilloteau
Article dans une revue
hal-02675958v1
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SIC, an intracerebral beta(+)-range-sensitive probe for radiopharmacology investigations in small laboratory animals: Binding studies with C-11-raclopride
L. Zimmer
,
W. Hassoun
,
Frederic Pain
,
F. Bonnefoi
,
P. Laniece
Journal of Nuclear Medicine, 2002, 43, pp.227-233
Article dans une revue
in2p3-00013611v1
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The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids
Luc Zimmer
,
Sylvie Vancassel
,
Sylvain Cantagrel
,
Patrick Breton
,
Séraphin Delamanche
Article dans une revue
hal-02675380v1
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Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission
S. Chalon
,
Sylvie Vancassel
,
L. Zimmer
,
D. Guilloteau
,
Georges Durand
Article dans une revue
hal-02683336v1
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Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex
L. Zimmer
,
Serge Delpal
,
D. Guilloteau
,
Josiane Aïoun
,
G. Durand
Neuroscience Letters, 2000, 284, pp.25-28
Article dans une revue
hal-02696603v1
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Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n-3 polyunsaturated fatty acids
Luc Zimmer
,
Sylvie Vancassel
,
Georges Durand
,
Denis Guilloteau
,
Sylvie Bodard
Journal of Lipid Research, 2000, 41 (1), 9 p
Article dans une revue
hal-02697599v1
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Chronic n-3 polyunsaturated fatty acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study
L. Zimmer
,
S. Hembert
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G. Durand
,
Pauline Breton
,
D. Guilloteau
Neuroscience Letters, 1998, 240, pp.177-181
Article dans une revue
hal-02697597v1
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