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Sami Halila

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Project Leader in Glycochemistry – CNRS Researcher ================================================== Our research is in the field of carbohydrate chemistry at the Interface between chemical biology and physical-chemistry. The importance of carbohydrates in biological and biophysical processes is now well established. They are involved, and in particular glycoconjugates (glycoproteins, glycolipids, etc.) in a plethora of biological processes ranging from cell-cell recognition and response (e.g. bacterial and viral infection, immune response, cancer metastasis, inflammation etc.), to the cellular membrane organization. We are particularly interested in chemical synthesis, e.g. the development of synthetic methodology, allowing the direct access to various precisely modified carbohydrates from protecting-group free strategies. These developments enable the preparation of biologically important (neo)glycoconjugates, or mimics of polysaccharides as binders or as regenerative matrix, or glyco-amphiphiles (glycolipids, block copolymers, grafted glycopolymers) with self-assembled properties in solution or in solid state (nanostructured materials, liquid crystals, supramolecular fibers). The applications are found in biomedical, electronic, biosensor, composites, soft matter, etc. And we are continually attempting to develop more versatile or efficient chemoselective methods, for example by the use of novel chemical platforms.

Publications

Arylidene Meldrum's Acid: A Versatile Structural Motif for the Design of Enzyme‐Responsive “Covalent‐Assembly” Fluorescent Probes with Tailor‐Made Properties**

Kévin Renault , Yoan Capello , Shun Yao , Sami Halila , Anthony Romieu
Chemistry - An Asian Journal, 2023, 18 (12), ⟨10.1002/asia.202300258⟩
Journal articles hal-04284824v1
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Interface Manipulations Using Cross-Linked Underlayers and Surface-Active Diblock Copolymers to Extend Morphological Diversity in High-χ Diblock Copolymer Thin Films

Noémie Baumgarten , Muhammad Mumtaz , Daniel Hermida Merino , Eduardo Solano , Sami Halila
ACS Applied Materials & Interfaces, 2023, 15 (19), pp.23736-23748. ⟨10.1021/acsami.3c02247⟩
Journal articles hal-04256396v1

Redox-responsive maltoheptaose-b-polystyrene nanoparticles containing zinc phthalocyanine: Formulation, photophysical properties, release kinetic and toxicity

Patrícia Regina Ebani , Jing Chen , Marcell Valandro Soares , Felix Alexandre Antunes Soares , Sami Halila
Journal of Drug Delivery Science and Technology, 2023, 88, pp.104838. ⟨10.1016/j.jddst.2023.104838⟩
Journal articles hal-04284799v1

Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair

Hua Wei , Shengkai Yu , Yansheng Zhang , Hua Zhang , Yuxi Ma
Carbohydrate Polymers, 2023, Carbohydrate Polymers, 313, pp.120904. ⟨10.1016/j.carbpol.2023.120904⟩
Journal articles hal-04284777v1
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Biodegradable Nanoparticles Loaded with Levodopa and Curcumin for Treatment of Parkinson’s Disease

Bassam Felipe Mogharbel , Marco André Cardoso , Ana Carolina Irioda , Priscila Elias Ferreira Stricker , Robson Camilotti Slompo
Molecules, 2022, 27 (9), pp.2811. ⟨10.3390/molecules27092811⟩
Journal articles hal-03875446v1
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Supramolecular carbohydrate-based hydrogels from oxidative hydroxylation of amphiphilic β-C-glycosylbarbiturates and α-glucosidase-induced hydrogelation

Shun Yao , Robin Brahmi , Anaïs Bouschon , Jing Chen , Sami Halila
Green Chemistry, 2022, 25 (1), pp.330-335. ⟨10.1039/D2GC04180D⟩
Journal articles hal-03920384v1
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Hierarchical Self‐Assembly of Amphiphilic β‐C‐Glycosylbarbiturates into Multiresponsive Alginate‐Like Supramolecular Hydrogel Fibers and Vesicle Hydrogel

Shun Yao , Robin Brahmi , François Portier , Jean-Luc Putaux , Jing Chen
Chemistry - A European Journal, 2021, ⟨10.1002/chem.202102950⟩
Journal articles hal-03377385v1

Ultrastretchable, Highly Transparent, Self-Adhesive, and 3D-Printable Ionic Hydrogels for Multimode Tactical Sensing

Hua Wei , Zhenwu Wang , Hua Zhang , Youju Huang , Zongbao Wang
Chemistry of Materials, 2021, 33 (17), pp.6731-6742. ⟨10.1021/acs.chemmater.1c01246⟩
Journal articles hal-03755476v1
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New Biobased Polyurethane Materials from Modified Vegetable Oil

Chakib Mokhtari , Fouad Malek , Sami Halila , Mohamed Naceur Belgacem , Ramzi Khiari
Journal of Renewable Materials, 2021, 9 (7), pp.1213-1223. ⟨10.32604/jrm.2021.015475⟩
Journal articles hal-03376617v1
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Ultrastretchable, Highly Transparent, Self-Adhesive, and 3D-Printable Ionic Hydrogels for Multimode Tactical Sensing

Hua Wei , Zhenwu Wang , Hua Zhang , Youju Huang , Zongbao Wang
Chemistry of Materials, 2021, 33 (17), pp.6731-6742. ⟨10.1021/acs.chemmater.1c01246⟩
Journal articles hal-03376651v1

Drug carrier systems made from self-assembled glyco-nanoparticles of maltoheptaose-b-polyisoprene enhanced the distribution and activity of curcumin against cancer cells

Bárbara Sthéfani Caldas , Danielle Lazarin-Bidóia , Celso Vataru Nakamura , Sami Halila , Redouane Borsali
Journal of Molecular Liquids, 2020, 309, pp.113022. ⟨10.1016/j.molliq.2020.113022⟩
Journal articles hal-02954391v1
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High‐Resolution Patterned Biobased Thin Films via Self‐Assembled Carbohydrate Block Copolymers and Nanocellulose

Marie Gestranius , Issei Otsuka , Sami Halila , Daniel Hermida‐merino , Eduardo Solano
Advanced Materials Interfaces, 2020, 7 (7), pp.1901737. ⟨10.1002/admi.201901737⟩
Journal articles hal-02998234v1
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Drug carrier systems made from self-assembled glyco-nanoparticles of maltoheptaose-b-polyisoprene enhanced the distribution and activity of curcumin against cancer cells

Bárbara Sthéfani Caldas , Danielle Lazarin-Bidóia , Celso Vataru Nakamura , Sami Halila , Redouane Borsali
Journal of Molecular Liquids, 2020, 309, pp.113022. ⟨10.1016/j.molliq.2020.113022⟩
Journal articles hal-02948775v1

Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent

Hua Zhang , Penggang Ren , Hua Wei , Sami Halila , Amarachi Rosemary Osi
Soft Matter, 2020, 16 (37), pp.8647-8654. ⟨10.1039/d0sm01099e⟩
Journal articles hal-03755492v1
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Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent

Hua Zhang , Penggang Ren , Hua Wei , Sami Halila , Amarachi Rosemary Osi
Soft Matter, 2020, ⟨10.1039/d0sm01099e⟩
Journal articles hal-02948762v1

Self-assembly of copper-free maltoheptaose-block-polystyrene nanostructured thin films in real and reciprocal space

Yingjie Liao , Laurent Goujon , Eric Reynaud , Sami Halila , Alain Gibaud
Carbohydrate Polymers, 2019, 212, pp.222-228. ⟨10.1016/j.carbpol.2019.02.014⟩
Journal articles hal-02954596v1
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Expeditious Synthesis of C -Glycosyl Barbiturate Ligands of Bacterial Lectins: From Monomer Design to Glycoclusters and Glycopolymers

François Portier , Anne Imberty , Sami Halila
Bioconjugate Chemistry, 2019, 30 (3), pp.647-656. ⟨10.1021/acs.bioconjchem.8b00847⟩
Journal articles hal-02322076v1
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N , N′ -Disubstituted Barbituric Acid: A Versatile and Modular Multifunctional Platform for Obtaining β- C -Glycoconjugates from Unprotected Carbohydrates in Water

François Portier , Justine Solier , Sami Halila
European Journal of Organic Chemistry, 2019, 2019 (36), pp.6158-6162. ⟨10.1002/ejoc.201901251⟩
Journal articles hal-02322037v1
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Lyotropic liquid crystals and linear supramolecular polymers of end-functionalized oligosaccharides

Teemu Myllymäki , Aynur Guliyeva , Antti Korpi , Mauri Kostiainen , Ville Hynninen
Chemical Communications, 2019, 55 (78), pp.11739-11742. ⟨10.1039/C9CC04715H⟩
Journal articles hal-02998259v1

Synthesis and characterization of carboxymethylcellulose grafted with thermoresponsive side chains of high LCST: The high temperature and high salinity self-assembly dependence

Nívia Do N. Marques , Rosangela de C. Balaban , Sami Halila , Redouane Borsali
Carbohydrate Polymers, 2018, 184, pp.108-117. ⟨10.1016/j.carbpol.2017.12.053⟩
Journal articles hal-02954624v1
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Synthesis and characterization of carboxymethylcellulose grafted with thermoresponsive side chains of high LCST: The high temperature and high salinity self-assembly dependence

Nívia Do N. Marques , Rosangela de C. Balaban , Sami Halila , Redouane Borsali
Carbohydrate Polymers, 2018, 184, pp.108-117. ⟨10.1016/j.carbpol.2017.12.053⟩
Journal articles hal-02322152v1
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Efficient Conjugation of Oligosaccharides to Polymer Particles through Furan/Maleimide Diels-Alder Reaction: Application to the Capture of Carbohydrate-Binding Proteins

Antoine Petrelli , Eric Samain , Stéphanie Pradeau , Sami Halila , Sébastien Fort
ChemBioChem, 2017, 18 (2), pp.206-212. ⟨10.1002/cbic.201600509⟩
Journal articles hal-02115628v1

Hemicellulosic Polysaccharides Mimics: Synthesis of Tailored Bottlebrush-Like Xyloglucan Oligosaccharide Glycopolymers as Binders of Nanocrystalline Cellulose

Jing Chen , Christophe Travelet , Redouane Borsali , Sami Halila
Biomacromolecules, 2017, 18 (10), pp.3410-3417. ⟨10.1021/acs.biomac.7b01056⟩
Journal articles hal-02322175v1

Conception of Stretchable Resistive Memory Devices Based on Nanostructure-Controlled Carbohydrate- block -Polyisoprene Block Copolymers

Chih-Chien Hung , Yu-Cheng Chiu , Hung-Chin Hung , Chien Lu , Cécile Bouilhac
Advanced Functional Materials, 2017, 27 (13), pp.1606161. ⟨10.1002/adfm.201606161⟩
Journal articles hal-02114459v1

Self-Assembly of Carbohydrate- block -Poly(3-hexylthiophene) Diblock Copolymers into Sub-10 nm Scale Lamellar Structures

Yoko Sakai-Otsuka , Soraia Zaioncz , Issei Otsuka , Sami Halila , Patrice Rannou
Macromolecules, 2017, 50 (8), pp.3365-3376. ⟨10.1021/acs.macromol.7b00118⟩
Journal articles hal-02114456v1

Redox tunable delivery systems: sweet block copolymer micelles via thiol–(bromo)maleimide conjugation

Antoine Petrelli , Redouane Borsali , Sébastien Fort , Sami Halila
Chemical Communications, 2016, 52 (82), pp.12202-12205. ⟨10.1039/C6CC07136H⟩
Journal articles hal-02119204v1
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Preparation of Polymeric Micelles of Poly(Ethylene Oxide-b-Lactic Acid) and their Encapsulation With Lavender Oil

Tatiane Popiolski , Issei Otsuka , Sami Halila , Edvani Muniz , Valdir Soldi
Materials Research, 2016, 19 (6), pp.1356-1365. ⟨10.1590/1980-5373-MR-2016-0430⟩
Journal articles hal-02114462v1

Sub-20 nm Microphase-Separated Structures in Hybrid Block Copolymers Consisting of Polycaprolactone and Maltoheptaose

Takuya Isono , Issei Otsuka , Sami Halila , Redouane Borsali , Toyoji Kakuchi
Journal of Photopolymer Science and Technology, 2015, 28 (5), pp.635-642. ⟨10.2494/photopolymer.28.635⟩
Journal articles hal-02114485v1

Nanoparticles Made From Xyloglucan-Block-Polycaprolactone Copolymers: Safety Assessment for Drug Delivery

Leticia Mazzarino , Gecioni Loch-Neckel , Lorena dos Santos Bubniak , Fabiana Ourique , Issei Otsuka
Toxicological Sciences, 2015, 147 (1), pp.104-115. ⟨10.1093/toxsci/kfv114⟩
Journal articles hal-02114476v1

CGTase-Catalysed cis -Glucosylation of L -Rhamnosides for the Preparation of Shigella flexneri 2a and 3a Haptens

Carole Urbach , Sami Halila , Catherine Guerreiro , Hugues Driguez , Laurence S Mulard
ChemBioChem, 2014, 15 (2), pp.293-300. ⟨10.1002/cbic.201300597⟩
Journal articles pasteur-02043361v1

High-Performance Nonvolatile Transistor Memories of Pentacence Using the Green Electrets of Sugar-based Block Copolymers and Their Supramolecules

Yu-Cheng Chiu , Issei Otsuka , Sami Halila , Redouane Borsali , Wen-Chang Chen
Advanced Functional Materials, 2014, 24 (27), pp.4240-4249. ⟨10.1002/adfm.201304297⟩
Journal articles hal-02114565v1

Redox-stimuli responsive micelles from DOX-encapsulating polycaprolactone-g-chitosan oligosaccharide

Alexandre Guerry , Sylvain Cottaz , Etienne Fleury , Julien Bernard , Sami Halila
Carbohydrate Polymers, 2014, 112, pp.746-752. ⟨10.1016/j.carbpol.2014.06.052⟩
Journal articles hal-01089690v1

Xyloglucan- block -Poly(ϵ-Caprolactone) Copolymer Nanoparticles Coated with Chitosan as Biocompatible Mucoadhesive Drug Delivery System

Leticia Mazzarino , Issei Otsuka , Sami Halila , Lorena dos Santos Bubniak , Suelen Mazzucco
Macromolecular Bioscience, 2014, 14 (5), pp.709-719. ⟨10.1002/mabi.201300465⟩
Journal articles hal-02114567v1

Control of 10 nm scale cylinder orientation in self-organized sugar-based block copolymer thin films

Issei Otsuka , Salomé Tallegas , Yoko Sakai , Cyrille Rochas , Sami Halila
Nanoscale, 2013, 5 (7), pp.2637-2641. ⟨10.1039/c3nr00332a⟩
Journal articles hal-02114580v1

Aniline-Catalyzed Reductive Amination as a Powerful Method for the Preparation of Reducing End-"Clickable" Chitooligosaccharides

Alexandre Guerry , Julien Bernard , Eric Samain , Etienne Fleury , Sylvain Cottaz
Bioconjugate Chemistry, 2013, 24, pp.544-549. ⟨10.1021/bc3003716⟩
Journal articles hal-00862391v1

Sub-10 nm Nano-Organization in AB 2 - and AB 3 -Type Miktoarm Star Copolymers Consisting of Maltoheptaose and Polycaprolactone

Takuya Isono , Issei Otsuka , Yohei Kondo , Sami Halila , Sébastien Fort
Macromolecules, 2013, 46 (4), pp.1461-1469. ⟨10.1021/ma3026578⟩
Journal articles hal-02114582v1

Block copolymer technology applied to nanoelectronics

Salomé Tallegas , Thierry Baron , Guillaume Gay , Claire Aggrafeil , Billel Salhi
physica status solidi (c), 2013, 10 (9), pp.1195-1206. ⟨10.1002/pssc.201300002⟩
Journal articles hal-02114577v1

10 nm Scale Cylinder–Cubic Phase Transition Induced by Caramelization in Sugar-Based Block Copolymers

Issei Otsuka , Takuya Isono , Cyrille Rochas , Sami Halila , Sébastien Fort
ACS Macro Letters, 2012, 1 (12), pp.1379-1382. ⟨10.1021/mz300543u⟩
Journal articles hal-02114585v1

Thermoresponsive Self-Assemblies of Cyclic and Branched Oligosaccharide- block -poly( N -isopropylacrylamide) Diblock Copolymers into Nanoparticles

Issei Otsuka , Christophe Travelet , Sami Halila , Sébastien Fort , Isabelle Pignot-Paintrand
Biomacromolecules, 2012, 13 (5), pp.1458-1465. ⟨10.1021/bm300167e⟩
Journal articles hal-02114597v1

Sweet Block Copolymer Nanoparticles: Preparation and Self-Assembly of Fully Oligosaccharide-Based Amphiphile

Samuel de Medeiros Modolon , Issei Otsuka , Sébastien Fort , Edson Minatti , Redouane Borsali
Biomacromolecules, 2012, 13 (4), pp.1129-1135. ⟨10.1021/bm3000138⟩
Journal articles hal-02114600v1

Oligosaccharide/Silicon-Containing Block Copolymers with 5 nm Features for Lithographic Applications

Julia Cushen , Issei Otsuka , Christopher Bates , Sami Halila , Sébastien Fort
ACS Nano, 2012, 6 (4), pp.3424-3433. ⟨10.1021/nn300459r⟩
Journal articles hal-02114592v1

Nano-Organization of Amylose-b-Polystyrene Block Copolymer Films Doped with Bipyridine

Karim Aissou , Issei Otsuka , Cyrille Rochas , Sébastien Fort , Sami Halila
Langmuir, 2011, 27 (7), pp.4098-4103. ⟨10.1021/la104936k⟩
Journal articles hal-00951650v1

Nano-Organization of Amylose- b -Polystyrene Block Copolymer Films Doped with Bipyridine

Karim Aissou , Issei Otsuka , Cyrille Rochas , Sébastien Fort , Sami Halila
Langmuir, 2011, 27 (7), pp.4098-4103. ⟨10.1021/la104936k⟩
Journal articles hal-02114617v1

Thermoresponsive Vesicular Morphologies Obtained by Self-Assemblies of Hybrid Oligosaccharide- block -poly( N -isopropylacrylamide) Copolymer Systems

Issei Otsuka , Keita Fuchise , Sami Halila , Sébastien Fort , Karim Aissou
Langmuir, 2010, 26 (4), pp.2325-2332. ⟨10.1021/la902743y⟩
Journal articles hal-02114632v1

Thermoresponsive Vesicular Morphologies Obtained by Self-Assemblies of Hybrid Oligosaccharide-block-poly(N-isopropylacrylamide) Copolymer Systems

Issei Otsuka , Keita Fuchise , Sami Halila , Sébastien Fort , Karim Aissou
Langmuir, 2010, 26 (4), pp.2325-2332. ⟨10.1021/la902743y⟩
Journal articles hal-00950666v1

Synthesis of new cellobiose-based glycopolysiloxanes and their use as polymer stabilizers in miniemulsion polymerisation

S. Berson , D. Viet , Sami Halila , H. Driguez , Etienne Fleury
Macromolecular Chemistry and Physics, 2008, pp.1814-1825
Journal articles hal-00320164v1

Syntheses of well-defined glyco-polyorganosiloxanes by "click" chemistry and their surfactant properties

Sami Halila , Maggy Manguian , Sébastien Fort , Sylvain Cottaz , Thierry Hamaide
Macromolecular Chemistry and Physics, 2008, 209 (12), pp.1282-1290
Journal articles hal-00373953v1

High resolution self-​assembled patterns on flexible nanocellulose film

Gestranius Sofi Marie , Issei Otsuka , Sami Halila , Redouane Borsali , Tekla Tammelin
257th ACS National Meeting & Exposition, Mar 2019, Orlando, FL, United States
Conference papers hal-02308460v1

Alkyne-functionalized Cellulose: Toward Green Tailored Biohybrid Conception

Gino Mangiante , Morgan Tizzotti , Alexandre Guerry , Sylvain Cottaz , Michel Petit-Conil
Workshop AXELERA-ARDI, May 2014, Grenoble, France
Conference papers hal-00996264v1

Click chemistry: an efficient tool for polysaccharide modifications

M. Tizzoti , C. Creuzet , M.P. Labeau , Thierry Hamaide , Eric Drockenmuller
Workshop International, Jun 2009, Marrakech, Morocco
Conference papers hal-00379042v1

Well-defined glyco-polyorganosiloxane by click chemistry

Sami Halila , Sébastien Fort , Sylvain Cottaz , Etienne Fleury , Thierry Hamaide
ISPO 07, 5th International Workshop of Silicon-based Polymers, Jun 2007, Montpellier, France
Conference papers hal-00380010v1

Nouveaux glyco-polyorganosiloxanes

Sami Halila , Hugues Driguez , Sylvain Cottaz , Thierry Hamaide , Etienne Fleury
Meeting of ADEME/AGRICE, May 2007, Paris, France
Conference papers hal-00381728v1

Synthèses et applications de glyco polysiloxanes à propriétés tensioactives. Vers de nouvelles voies de synthèses par click chemistry

Thierry Hamaide , S. Berson , Etienne Fleury , Sami Halila , Hugues Driguez
37ème Colloque Annuel du Groupe Français des Polymères (GFP), Nov 2007, Strasbourg, France
Conference papers hal-00381730v1

Syntheses of well-Designed glyco-polyorganosiloxanes and their surface active properties

Sami Halila , Maggy Manguian , Thierry Hamaide , Etienne Fleury , Hugues Driguez
Second Chemical Workshop France Lyon- China- Xiamen, Oct 2007, Xiamen, China
Conference papers hal-00380012v1

Syntheses of well-designed glyco-polyorganosiloxanes and their surface active properties

Sami Halila , Maggy Manguian , Thierry Hamaide , Etienne Fleury , Hugues Driguez
Second Chemical Workshop France Lyon- China- Xiamen, Oct 2007, Xiamen, China
Conference papers hal-00378937v1