Sebastien Benzekry

Head of the Inria – Inserm project team COMPO (COMPutational pharmacology and clinical Oncology)
84 %
Libre accès
147
Documents
Affiliation actuelle
  • Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO)

Présentation

Sebastien Benzekry is a scientific researcher (PhD, HDR) at Inria, the french institute for applied mathematics, computer science and their applications. He has created (in 2021) and heads the Inria – Inserm (French national institute for biomedical research) project-team COMPO (COMPutational pharmacology and clinical Oncology), affiliated to both Inria and the Center for Research on Cancer of Marseille (Inserm U1068, CNRS UMR7258, Institut Paoli-Calmettes Institute, Aix-Marseille University, Faculty of Pharmacy). The objective of his research is to model data arising from (clinical) oncology in order to 1) bring clinical decision tools to enhance therapeutic management, 2) better inform and design clinical trials and 3) test biological hypotheses. To do so, he combines mechanistic (i.e., simulation models of the pharmaco-patho-physiological processes in cancer) and statistical learning through an approach termed 'mechanistic learning'. He has fifteen years of experience in trans-disciplinary projects in oncology, with a strong track record of publications in high impact journals (Cancer Res, PLoS Comp Biol, Clin Pharmacol Ther,...). His main topics of research are modeling metastatic development and immuno-oncology, integrating longitudinal data. These are implemented into code libraries developed with a focus on software development standards.

Dr Benzekry has an initial training in applied mathematics (Ecole Normale Supérieure) followed by a PhD at Aix-Marseille University and further training in computational / systems biology as a postdoc in the Center for Cancer and Systems Biology, Tufts Univ, Boston, MA.

Citations: 2095, h-index 24 (11/2011 – 03/2024), 50 research articles, 24 book chapters, editorials and proceedings.

https://team.inria.fr/compo/ https://www-sop.inria.fr/members/Sebastien.Benzekry/index.html https://scholar.google.fr/citations?user=xsLpdFAAAAAJ&hl=fr&oi=ao

Publications

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Publications

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Computational modeling for circulating cell-free DNA in clinical oncology

Linh Nguyen Phuong , Sébastien Salas , Sébastien Benzekry

JCO Clinical Cancer Informatics, 2025, 9, ⟨10.1200/CCI-24-00224⟩

Article dans une revue hal-04481689v3
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Digital Pharmacological Twins: Bridging Multi-scale Modelling and Artificial Intelligence for Precision Medicine : the DIGPHAT consortium

Jean-Baptiste Woillard , Sébastien Benzekry , Julie Josse , Mélanie White-Koning , Etienne Chatelut et al. Article dans une revue hal-05288607v1
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Optimizing First‐Line Therapeutics in Non‐Small Cell Lung Cancer: Insights From Joint Modeling and Large‐Scale Data Analysis

Benjamin K Schneider , Sébastien Benzekry , Jonathan P Mochel

CPT: Pharmacometrics and Systems Pharmacology, 2025, ⟨10.1002/psp4.70079⟩

Article dans une revue hal-05198474v1
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A senescence-mimicking (senomimetic) VEGFR TKI side-effect primes tumor immune responses via IFN/STING signaling

Melissa Dolan , Yuhao Shi , Michalis Mastri , Mark Long , Amber Mckenery et al.

Molecular Cancer Therapeutics, In press, Online ahead of print. ⟨10.1158/1535-7163.MCT-24-0139⟩

Article dans une revue hal-04571490v1
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Predicting Survival in Patients with Advanced NSCLC Treated with Atezolizumab Using Pre‐ and on‐Treatment Prognostic Biomarkers

Sébastien Benzekry , Mélanie Karlsen , Célestin Bigarré , Abdessamad El Kaoutari , Bruno Gomes et al.

Clinical Pharmacology and Therapeutics, 2024, 116 (4), pp.1110-1120. ⟨10.1002/cpt.3371⟩

Article dans une revue hal-04647230v1
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Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

Kevin Atsou , Anne Auperin , Jôel Guigay , Sébastien Salas , Sébastien Benzekry

CPT: Pharmacometrics and Systems Pharmacology, 2024, ⟨10.1002/psp4.13294⟩

Article dans une revue hal-04558029v2
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Lack of Prophylactic Cranial Irradiation for Extensive Small-Cell Lung Cancer in Real Life, with the Emergence of Immunotherapy

Alice Daumas , Celestin Bigarre , Mohamed Boucekine , Audrey Zaccariotto , Bertrand Kaeppelin et al.

Cancers, 2024, 16 (23), pp.4122. ⟨10.3390/cancers16234122⟩

Article dans une revue hal-04863847v1
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Machine-learning and mechanistic modeling of primary and metastatic breast cancer growth after neoadjuvant targeted therapy

Sébastien Benzekry , Michalis Mastri , Chiara Nicolò , John Ebos

PLoS Computational Biology, 2024, 20 (5), pp.e1012088. ⟨10.1371/journal.pcbi.1012088⟩

Article dans une revue hal-04384182v2
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Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors

Yuhao Shi , Amber Mckenery , Melissa Dolan , Michalis Mastri , James W Hill et al.

EMBO Reports, 2024, 26, pp.521 - 559. ⟨10.1038/s44319-024-00333-0⟩

Article dans une revue hal-04387866v2
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Reuniting philosophy and science to advance cancer research.

Thomas Pradeu , Bertrand Daignan-Fornier , Andrew Ewald , Pierre-Luc Germain , Samir Okasha et al.

Biological Reviews, In press, ⟨10.1111/brv.12971⟩

Article dans une revue hal-04190936v1
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Mechanistic modeling of metastatic relapse in early breast cancer to investigate the biological impact of prognostic biomarkers

Célestin Bigarré , François Bertucci , Pascal Finetti , Gaëtan Macgrogan , Xavier Muracciole et al.

Computer Methods and Programs in Biomedicine, 2023, 231, pp.107401. ⟨10.1016/j.cmpb.2023.107401⟩

Article dans une revue hal-04008520v1

Computational markers for personalized prediction of outcomes in non-small cell lung cancer patients with brain metastases

Sébastien Benzekry , Pirmin Schlicke , Alice Mogenet , Laurent Greillier , Pascale Tomasini et al.

Clinical and Experimental Metastasis, 2023, ⟨10.1007/s10585-023-10245-3⟩

Article dans une revue hal-04360487v1

Des modèles mathématiques pour la recherche clinique en cancérologie

Sébastien Benzekry

Interstices, 2022, ⟨10.60527/7cky-8075⟩

Article dans une revue hal-03746564v1
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Macro-scale models for fluid flow in tumour tissues: impact of microstructure properties

Cristina Vaghi , Raphaëlle Fanciullino , Sébastien Benzekry , Clair Poignard

Journal of Mathematical Biology, 2022, 84, pp.27. ⟨10.1007/s00285-022-01719-1⟩

Article dans une revue hal-02891573v1
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Practical identifiability analysis of a mechanistic model for the time to distant metastatic relapse and its application to renal cell carcinoma

Arturo Álvarez-Arenas , Wilfried Souleyreau , Andrea Emanuelli , Lindsay S Cooley , Jean-Christophe Bernhard et al.

PLoS Computational Biology, 2022, 18, ⟨10.1371/journal.pcbi.1010444⟩

Article dans une revue hal-03921339v1
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Asymptotic analysis of a biphase tumor fluid flow: the weak coupling case.

Cristina Vaghi , Sébastien Benzekry , Clair Poignard

Applied Mathematics and Computation, 2022, 413, pp.126635. ⟨10.1016/j.amc.2021.126635⟩

Article dans une revue hal-03354766v2
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Tumor growth monitoring in breast cancer xenografts: A good technique for a strong ethic

Anne Rodallec , Cristina Vaghi , Joseph Ciccolini , Raphaëlle Fanciullino , Sebastien Benzekry

PLoS ONE, 2022, 17 (9), pp.e0274886. ⟨10.1371/journal.pone.0274886⟩

Article dans une revue hal-03924541v1
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Machine Learning for Prediction of Immunotherapy Efficacy in Non-Small Cell Lung Cancer from Simple Clinical and Biological Data

Sébastien Benzekry , Mathieu Grangeon , Mélanie Karlsen , Maria Alexa , Isabella Bicalho-Frazeto et al.

Cancers, 2021, 13 (24), pp.6210. ⟨10.3390/cancers13246210⟩

Article dans une revue hal-03478003v2
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Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression

Lindsay Cooley , Justine Rudewicz , Wilfried Souleyreau , Andrea Emanuelli , Arturo Alvarez-Arenas et al.

Molecular Cancer, 2021, 20, pp.136. ⟨10.1186/s12943-021-01416-5⟩

Article dans une revue hal-03390517v1

Mechanistic models for hematological toxicities: Small is beautiful

Laure Deyme , Sébastien Benzekry , Joseph Ciccolini

CPT: Pharmacometrics and Systems Pharmacology, 2021, 10 (5), pp.396-398. ⟨10.1002/psp4.12590⟩

Article dans une revue hal-05240046v1
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Development and Validation of a Prediction Model of Overall Survival in High-Risk Neuroblastoma Using Mechanistic Modeling of Metastasis

Sébastien Benzekry , Coline Sentis , Carole Coze , Laëtitia Tessonnier , Nicolas André

JCO Clinical Cancer Informatics, 2021, 5, pp.81-90. ⟨10.1200/CCI.20.00092⟩

Article dans une revue hal-03147049v1
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Artificial Intelligence and Mechanistic Modeling for Clinical Decision Making in Oncology

Sébastien Benzekry

Clinical Pharmacology and Therapeutics, 2020, ⟨10.1002/cpt.1951⟩

Article dans une revue hal-02916941v1
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Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors

Cristina Vaghi , Anne Rodallec , Raphaëlle Fanciullino , Joseph Ciccolini , Jonathan P Mochel et al.

PLoS Computational Biology, 2020, 16 (2), pp.e1007178. ⟨10.1371/journal.pcbi.1007178⟩

Article dans une revue inserm-02515955v1
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Deciphering the response and resistance to immunecheckpoint inhibitors in lung cancer with artificial intelligence-based analysis: the pioneer and quantic joint-projects

Joseph Ciccolini , Sébastien Benzekry , Fabrice Barlesi

British Journal of Cancer, 2020, 123 (3), pp.337-338. ⟨10.1038/s41416-020-0918-3⟩

Article dans une revue hal-03147110v1
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Machine Learning and Mechanistic Modeling for Prediction of Metastatic Relapse in Early-Stage Breast Cancer

Chiara Nicolò , Cynthia Périer , Mélanie Prague , Carine Bellera , Gaëtan Macgrogan et al.

JCO Clinical Cancer Informatics, 2020, 4, pp.259-274. ⟨10.1200/CCI.19.00133⟩

Article dans une revue hal-02942177v1
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Mechanistic Learning for Combinatorial Strategies With Immuno-oncology Drugs: Can Model-Informed Designs Help Investigators?

Joseph Ciccolini , Dominique Barbolosi , Nicolas André , Fabrice Barlesi , Sébastien Benzekry

JCO precision oncology, 2020, 108 (4), pp.486-491. ⟨10.1200/PO.19.00381⟩

Article dans une revue hal-03147084v1
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Prédiction de l'efficacité de l'immunothérapie dans le cancer bronchique à partir de données cliniques et biologiques simples : apport de l'intelligence artificielle

Mathieu Grangeon , Sebastien Benzekry , Solène Chaleat , Pascale Tomasini , Dominique Barbolosi et al.

Revue des Maladies Respiratoires Actualites, 2020, 12 (1), pp.217. ⟨10.1016/j.rmra.2019.11.477⟩

Article dans une revue hal-03147118v1
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Combinatorial immunotherapy strategies : most gods throw dice, but fate plays chess

Joseph Ciccolini , Dominique Barbolosi , Nicolas Andre , Sébastien Benzekry , Fabrice Barlesi

Annals of Oncology, 2019, ⟨10.1093/annonc/mdz297⟩

Article dans une revue hal-02383826v1
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Quantitative mathematical modeling of clinical brain metastasis dynamics in non-small cell lung cancer

Maria Bilous , Cindy Serdjebi , Arnaud Boyer , Claudia Pouypoudat , Pascale Tomasini et al.

Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-49407-3⟩

Article dans une revue hal-01928442v2
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Optimal Scheduling of Bevacizumab and Pemetrexed/cisplatin Dosing in Non‐Small Cell Lung Cancer

Benjamin K Schneider , Arnaud Boyer , Joseph Ciccolini , Fabrice Barlesi , Kenneth Wang et al.

CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12415⟩

Article dans une revue hal-02109335v1
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CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies

Jonathan Paul M. Mochel , Stephen C Ekker , Chad Johannes , Albert E Jergens , Karin Allenspach et al.

AAPS Journal, 2019, 21 (3), ⟨10.1208/s12248-019-0322-1⟩

Article dans une revue hal-02099159v1
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Is There Any Room for Pharmacometrics With Immuno-Oncology Drugs? Input from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

Anne Rodallec , Raphaelle Fanciullino , Sébastien Benzekry , Joseph Ciccolini

Anticancer Research, 2019, 39 (7), pp.3419-3422. ⟨10.21873/anticanres.13486⟩

Article dans une revue hal-02383831v1
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Combinatorial immunotherapy strategies: most gods throw dice, but fate

Joseph Ciccolini , Dominique Barbolosi , Nicolas André , Sebastien Benzekry , Fabrice Barlesi

Annals of Oncology, 2019, 30 (11), pp.1690-1691. ⟨10.1093/annonc/mdz297/5559268⟩

Article dans une revue hal-03147132v1
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Turning cold tumors into hot tumors: harnessing the potential of tumor immunity using nanoparticles

Anne Rodallec , Guillaume Sicard , Raphaelle Fanciullino , Sébastien Benzekry , Bruno Lacarelle et al.

Expert Opinion on Drug Metabolism and Toxicology, 2018, 14 (11), pp.1-9. ⟨10.1080/17425255.2018.1540588⟩

Article dans une revue hal-01958583v1
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Revisiting bevacizumab + cytotoxics scheduling using mathematical modeling: proof of concept study in experimental non-small cell lung carcinoma

Diane-Charlotte Imbs , Raouf El Cheikh , Arnaud Boyer , Joseph Ciccolini , Celine Mascaux et al.

CPT: Pharmacometrics and Systems Pharmacology, 2018, pp.1-9. ⟨10.1002/psp4.12265⟩

Article dans une revue hal-01624423v2
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Pharmacokinetics variability: why nanoparticles are not magic bullets in oncology

Anne Rodallec , Sébastien Benzekry , Bruno Lacarelle , Joseph Ciccolini , Raphaelle Fanciullino

Critical Reviews in Oncology/Hematology, 2018, 129, pp.1 - 12. ⟨10.1016/j.critrevonc.2018.06.008⟩

Article dans une revue hal-01821678v1
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Mathematical modeling of tumor-tumor distant interactions supports a systemic control of tumor growth

Sébastien Benzekry , Clare Lamont , Dominique Barbolosi , Lynn Hlatky , Philip Hahnfeldt

Cancer Research, 2017, ⟨10.1158/0008-5472.CAN-17-0564⟩

Article dans une revue hal-01566947v1
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Model-driven optimization of antiangiogenics + cytotoxics combination: application to breast cancer mice treated with bevacizumab + paclitaxel doublet leads to reduced tumor growth and fewer metastasis

Severine Mollard , Joseph Ciccolini , Diane-Charlotte Imbs , Raouf El Cheikh , Dominique Barbolosi et al. Article dans une revue hal-01474679v1
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Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas

Araceli M Henares-Molina , Sébastien Benzekry , Pedro C Lara , Marcial M García-Rojo , Víctor M Pérez-García et al. Article dans une revue hal-01532505v1

Etude de l'effet séquence bevacizumab/pemetrexed/cisplatine chez la souris porteuse de cancer du poumon non à petites cellules

Arnaud Boyer , Joseph Ciccolini , Céline Mascaux , Diane-Charlotte Imbs , Raouf El Cheikh et al.

Revue des Maladies Respiratoires, 2017, 34, ⟨10.1016/j.rmr.2016.10.110⟩

Article dans une revue hal-01540322v1

Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach

Madeleine Benguigui , Dror Alishekevitz , Michael Timaner , Dvir Shechter , Ziv Raviv et al.

Oncotarget, 2017, 9 (2), pp.2574-2590. ⟨10.18632/oncotarget.23514⟩

Article dans une revue hal-01672568v1
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In Vivo Bioluminescence Tomography for Monitoring Breast Tumor Growth and Metastatic Spreading: Comparative Study and Mathematical Modeling

Séverine Mollard , Raphaelle Fanciullino , Sarah Giacometti , Cindy Serdjebi , Sebastien Benzekry et al.

Scientific Reports, 2016, 6, pp.10. ⟨10.1038/srep36173⟩

Article dans une revue hal-01392861v1
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Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach

Sébastien Benzekry , Amanda Tracz , Michalis Mastri , R. Corbelli , Dominique Barbolosi et al.

Cancer Research, 2016, 76 (3), pp.535 - 547. ⟨10.1158/0008-5472.CAN-15-1389⟩

Article dans une revue hal-01222046v2
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Next generation metronomic chemotherapy - report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6 - 8 May 2016, Mumbai

Pan G Pantziarka , Lisa Hutchinson , Nicolas G André , Sébastien Benzekry , Francesco Bertolini et al.

Ecancermedicalscience, 2016, 10, ⟨10.3332/ecancer.2016.689⟩

Article dans une revue hal-01392473v1
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Les lois de la croissance tumorale

Sébastien Benzekry

Bibliothèque Tangente, 2016

Article dans une revue hal-01418295v1

Mathematical modeling of cancer immunotherapy and its synergy with radiotherapy

R. Serre , Sébastien Benzekry , Laetitia Padovani , C. Meille , N. Andre et al.

Cancer Research, 2016, ⟨10.1158/0008-5472.CAN-15-3567⟩

Article dans une revue hal-01336779v1
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Metronomic Reloaded: Theoretical Models Bringing Chemotherapy into the Era of Precision Medicine

Sébastien Benzekry , Eddy Pasquier , Dominique Barbolosi , Bruno Lacarelle , Fabrice Barlési et al.

Seminars in Cancer Biology, 2015, pp.23. ⟨10.1016/j.semcancer.2015.09.002⟩

Article dans une revue hal-01195547v1
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Computational Modelling of Metastasis Development in Renal Cell Carcinoma

Etienne Baratchart , Sébastien Benzekry , Andreas Bikfalvi , Thierry Colin , Lindsay S. Cooley et al.

PLoS Computational Biology, 2015, 11 (11), ⟨10.1371/journal.pcbi.1004626⟩

Article dans une revue hal-01164834v2

Improving efficacy of the combination between antiangiogenic and chemotherapy: Time for mathematical modeling support

Joseph Ciccolini , Sébastien Benzekry , Bruno Lacarelle , Dominique Barbolosi , Fabrice Barlesi

Proceedings of the National Academy of Sciences of the United States of America, 2015, pp.1. ⟨10.1073/pnas.1506689112⟩

Article dans une revue hal-01168635v1

Host Age Is a Systemic Regulator of Gene Expression Impacting Cancer Progression

Afshin Beheshti , Sebastien Benzekry , J. Tyson Mcdonald , Lili Ma , Michael Peluso et al.

Cancer Research, 2015, 75 (6), pp.10. ⟨10.1158/0008-5472.CAN-14-1053⟩

Article dans une revue hal-01132048v1
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Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks

Sebastien Benzekry , Jack A Tuszynski , Edward A Rietman , Giannoula Lakka Klement

Biology Direct, 2015, pp.14. ⟨10.1186/s13062-015-0058-5⟩

Article dans une revue hal-01158313v1
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Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth

Sebastien Benzekry , Afshin Beheshti , Philip Hahnfeldt , Lynn Hlatky

Bio-protocol , 2015, 5 (21)

Article dans une revue hal-01222068v1
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Classical Mathematical Models for Description and Forecast of Experimental Tumor Growth

Sébastien Benzekry , Clare Lamont , Afshin Beheshti , Amanda Tracz , John M.L. Ebos et al.

PLoS Computational Biology, 2014, 10 (8), pp.e1003800. ⟨10.1371/journal.pcbi.1003800⟩

Article dans une revue hal-00922553v6
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Global Dormancy of Metastases due to Systemic Inhibition of Angiogenesis

Sébastien Benzekry , Alberto Gandolfi , Philip Hahnfeldt

PLoS ONE, 2014, 9 (1), pp.e84249. ⟨10.1371/journal.pone.0084249⟩

Article dans une revue hal-00868592v3

Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice.

Floriane Lignet , Sébastien Benzekry , Shelby Wilson , Frédérique Billy , Olivier Saut et al.

Journal of Theoretical Biology, 2013, 320, pp.86-99. ⟨10.1016/j.jtbi.2012.12.013⟩

Article dans une revue istex hal-00785876v1
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Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers.

Sebastien Benzekry , Philip Hahnfeldt

Journal of Theoretical Biology, 2013, 335, pp.235-44. ⟨10.1016/j.jtbi.2013.06.036⟩

Article dans une revue hal-00836032v1
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A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology

Sébastien Benzekry , Guillemette Chapuisat , Joseph Ciccolini , Alice Erlinger , Florence Hubert

Comptes rendus de l'Académie des sciences. Série I, Mathématique, 2012, 350, pp.23-28. ⟨10.1016/j.crma.2011.11.019⟩

Article dans une revue hal-00641476v2
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Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers

Sebastien Benzekry

ESAIM: Mathematical Modelling and Numerical Analysis, 2012, 46 (2), pp.207-237

Article dans une revue hal-00518110v1
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Modeling the impact of anticancer agents on metastatic spreading

Sébastien Benzekry , Nicolas André , Assia Benabdallah , Joseph Ciccolini , Christian Faivre et al.

Mathematical Model Natural Phenomenon, 2012, 7 (1), pp 306--336. ⟨10.1051/mmnp/20127114⟩

Article dans une revue hal-00657724v1
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Passing to the limit 2D-1D in a model for metastatic growth

Sebastien Benzekry

Journal of Biological Dynamics, 2011, pp.10.1080/17513758.2011.568071. ⟨10.1080/17513758.2011.568071⟩

Article dans une revue hal-00521968v1
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Mathematical analysis of a two-dimensional population model of metastatic growth including angiogenesis

Sebastien Benzekry

Journal of Evolution Equations, 2011, 11 (1), pp.187-213

Article dans une revue hal-00516693v1
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Mechanistic Modeling of Joint Circulating Cell-free DNA Concentration—Tumor Size Kinetics under Immune-Checkpoint Inhibitors in Advanced Cancer

Linh Nguyen Phuong , Frederic Fina , Romain Zakrajsek , Lucie Della-Negra , Pascale Tomasini et al.

PAGE 2025 - 33th Annual meeting of the Population Approach Group of Europe, Jun 2025, Thessalokini, Greece

Communication dans un congrès hal-05241536v1
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Mechanistic Learning to predict the results of clinical trials

Sébastien Benzekry

AMLD 2024 - Applied Machine Learning Days, Mar 2024, Lausanne, Switzerland

Communication dans un congrès hal-04990478v1
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Precision Immuno-Oncology in NSCLC: Challenges in machine learning biomarkers research

Sébastien Benzekry

EORTC PAMM 2024 - 44th Meeting of the European Organization of Research and Treatment of Cancer (EORTC) – Pharmacology and Molecular Mechanisms (PAMM) Group, Feb 2024, Marseille, France

Communication dans un congrès hal-04990474v1

Integrating tumor kinetics and circulating cell-free DNA markers through mechanistic modeling for early prediction of immunotherapy response

Linh Nguyen Phuong , Frederic Fina , Laurent Greillier , Caroline Gaudy-Marqueste , Jean-Laurent Deville et al.

KSMB-SMB 2024 - Joint annual meeting of the Korean Society for Mathematical Biology and the Society for Mathematical Biology, Jul 2024, Seoul, South Korea

Communication dans un congrès hal-04665038v1

Mechanistic modelling of tumor kinetics coupled with biomarker dynamics for survival prediction in non-small cell lung cancer patients

Ruben Taieb , René Bruno , Jin Jin , Pascal Chanu , Sébastien Benzekry

PAGE meeting XXXII - 2024 Population approach group meeting, 2024, Roma, France

Communication dans un congrès hal-04880274v1

Integrating kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry

ECMTB 2024 - European Conference on Theoretical and Mathematical Biology, Jul 2024, Toledo (Spain), Spain

Communication dans un congrès hal-04990489v1
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Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry

KSMB-SMB 2024 - Joint annual meeting of the Korean Society for Mathematical Biology and the Society for Mathematical Biology, Jun 2024, Seoul, South Korea

Communication dans un congrès hal-04990485v1
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Machine Learning to Predict Survival and Resistance to Immune Checkpoint Inhibition

Sébastien Benzekry

Twelfth International Workshop on Pharmacodynamics of Anticancer Agents, Sep 2024, Ponta Delgada (Açores), Portugal

Communication dans un congrès hal-04990492v1
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Une comparaison des algorithmes d'apprentissage pour la survie avec données manquantes

Paul Dufossé , Sébastien Benzekry

JDS 2023 - 54e Journées de Statistique de la SFds, SFdS, Jul 2023, Bruxelles (BEL), Belgique. ⟨10.48550/arXiv.2303.13590⟩

Communication dans un congrès hal-04384220v1

Artificial intelligence in healthcare data warehouses

Sébastien Benzekry

Annual congress of the French group of clinical pneumo-oncology (GPCO), Jun 2023, Toulon, France

Communication dans un congrès hal-04388413v1

Using statistical learning for clinical trials

Sébastien Benzekry

Annual meeting of the APHM center for early phase clinical trials in oncology, Jun 2023, Marseille, France

Communication dans un congrès hal-04388605v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry

SMAI 2023 congress - 11th French Biennial of Applied and Industrial Mathematics, May 2023, Le Gosier (Guadeloupe), France

Communication dans un congrès hal-04388478v1

Mechanistic modeling of the longitudinal tumor and biological markers combined with quantitative cell-free DNA

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia et al.

2023 SMB annual meeting - Annual Meeting of the Society for Mathematical Biology, Society for Mathematical Biology, Jul 2023, Columbus (Ohio), United States

Communication dans un congrès hal-04388020v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry

Annual congress of the French society of pharmacology and therapeutics (SFPT), Jun 2023, Limoges, France

Communication dans un congrès hal-04388499v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry

Workshop for young researchers in Cancer 2023, Cancéropôle PACA, Oct 2023, Porquerolles, France

Communication dans un congrès hal-04388572v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry

CARe graduate school workshop, Jan 2023, Toulouse, France

Communication dans un congrès hal-04388750v1
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Mechanistic modeling of the combination between cytotoxics and anti-angiogenics for sequence optimization

Sébastien Benzekry

Quantitative Systems Pharmacology, Leiden University, Apr 2022, Leiden (Netherlands), Netherlands

Communication dans un congrès hal-05239911v1
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3MO - Comprehensive biomarkers (BMs) analysis to predict efficacy of PD1/L1 immune checkpoint inhibitors (ICIs) in combination with chemotherapy: a subgroup analysis of the Precision Immuno-Oncology for advanced Non-Small CEll Lung CancER (PIONeeR) trial

Fabrice Barlesi , Laurent Greillier , Florence Monville , C Audigier-Valette , S. Martinez et al.

2022 ESMO Immuno-Oncology Congress, Dec 2022, Geneva, Switzerland

Communication dans un congrès hal-03928784v1
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Supporting decision making and early prediction of survival for oncology drug development using a pharmacometrics-machine learning based model

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , René Bruno , Aleš Neubert et al.

PAGE - Population Approach Group Europe, Jun 2022, Ljubljana, Slovenia

Communication dans un congrès hal-03921394v1

Quantitative modeling of metastasis: cancer at the organism scale

Sébastien Benzekry

8th international conference on Systems Biology of Mammalian Cells: From Systems Medicine towards Digital Health, May 2022, Heidelberg (Germany), Germany

Communication dans un congrès hal-05239921v1

Quantitative modeling of metastasis: cancer at the organism scale

Sébastien Benzekry

Mini-symposium "Mathematical approaches to advance clinical studies in oncology", Annual conference of the Society of Mathematical Biology (SMB), 2021, Virtual conference, United States

Communication dans un congrès hal-05239934v1
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Data-driven mechanistic modeling of metastasis: cancer at the organism scale

Sébastien Benzekry

RITS conference (Recherche en Imagerie et Technologies pour la Sante) of the French Society of Biomedical Engineering (SFGBM), May 2019, Tours, France

Communication dans un congrès hal-02424452v2
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Machine learning versus mechanistic modeling for prediction of metastatic relapse in breast cancer

Sebastien Benzekry

2019 CSBC-PSON Mathematical Oncology Meeting, May 2019, Portland, United States

Communication dans un congrès hal-02424419v1
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Mechanistic modeling of metastasis: cancer at the organism scale

Sébastien Benzekry

International Society of Pharmacometrics (ISoP) workshop, Jul 2019, Paris, France

Communication dans un congrès hal-02424424v1
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Mathematical Modeling of Tumor-Tumor Distant Interactions Supports a Systemic Control of Tumor Growth

Sébastien Benzekry

3rd Mathematical Biology Modeling days of Besançon, Jun 2018, Besançon, France

Communication dans un congrès hal-01969102v1
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Mathematical Modeling and Prediction of Clinical Metastasis

Sébastien Benzekry

Mathematical Challenges in the Analysis of Continuum Models for Cancer Growth, Evolution and Therapy, Nov 2018, Oaxaca, Mexico

Communication dans un congrès hal-01969108v1
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Optimization of sequential administration of bevacizumab plus cytotoxics in non-small cell lung cancer by combining in vivo experiments and mathematical modeling

Sébastien Benzekry

Mathematical perspectives in the biology and therapeutics of cancer, Jul 2018, Marseille, France

Communication dans un congrès hal-01969142v1

Optimized radiotherapy protocols delay the malignant transformation of low-grade gliomas in-silico

Araceli Henares-Molina , Sébastien Benzekry , Pedro Lara , Marcial García-Rojo , Victor Pérez-García et al.

5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies, May 2017, Zurich, Switzerland. pp.iii12 - iii12, ⟨10.1093/neuonc/nox036.040⟩

Communication dans un congrès hal-01517899v1

Abstract 2099: Model-driven optimization of anti-angiogenics combined with chemotherapy: application to bevacizumab + pemetrexed/cisplatin doublet in NSCLC-bearing mice

Joseph Ciccolini , Sebastien Benzekry , Sarah Giacometti , Fabrice Barlesi , Dominique Barbolosi

107th Annual Meeting of the American Association for Cancer Research, 2016, New Orleans, France. pp.20, ⟨10.1158/1538-7445.AM2016-2099⟩

Communication dans un congrès hal-01404637v1
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On the growth and dissemination laws in a mathematical model of metastatic growth

Sébastien Benzekry , John M.L. Ebos

Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500007⟩

Communication dans un congrès hal-01222088v1
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A mathematical model of systemic inhibition of angiogenesis in metastatic development

Sébastien Benzekry , Alberto Gandolfi , Philip Hahnfeldt

Congres SMAI 2013, May 2013, Seignosse, France. pp.75-87, ⟨10.1051/proc/201445008⟩

Communication dans un congrès hal-00867992v1

Model-based optimization of combined antiangiogenic + cytotoxics modalities: application to the bevacizumab-paclitaxel association in breast cancer models

Séverine Mollard , Sébastien Benzekry , Giacometti Sarah , Christian Faivre , Florence Hubert et al.

AACR Annual Meeting 2014, Apr 2014, San Diego, United States. ⟨10.1158/1538-7445.AM2014-3677⟩

Communication dans un congrès hal-01090883v1
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Model-driven scheduling of a novel anti-cancer prodrug administered subcutaneously

Anne Rodallec , Randy Lee , Jingming Cao , Sophie Marolleau , Julien Nicolas et al.

PAGE, Jun 2025, Thessalonic, Greece

Poster de conférence hal-05241394v1
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Cell-Free DNA Fragmentome Dynamics as a Biomarker for Immune-Checkpoint Inhibition in Advanced Carcinoma

Linh Nguyen Phuong , Frederic Fina , Romain Zakrajsek , Lucie Della-Negra , Laurent Greillier et al.

AACR 2025 - Annual meeting of American Association for Cancer Research, Apr 2025, Chicago, United States. ⟨10.1158/1538-7445.AM2025-3697⟩

Poster de conférence hal-05241485v1

Mathematical modeling of routine biological parameters kinetics in order to predict durable benefit for first-line immunotherapy in metastatic or unresectable melanoma.

Jessica Forestier , Alice Julie Daumas , Marie-Aleth Richard , Caroline Gaudy-Marqueste , Sébastien Benzekry et al.

2024 ASCO Annual Meeting - American Society of Clinical Oncology Annual meeting 2024, Jun 2024, Chicago (USA), United States. Journal of Clinical Oncology, 42 (16_suppl), pp.e21549-e21549, 2024, ⟨10.1200/jco.2024.42.16_suppl.e21549⟩

Poster de conférence hal-04713615v1
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PK/PD modelling to advance the preclinical development of a novel polymer prodrug in oncology

Anne Rodallec , Randy Lee , Sophie Marolleau , Sébastien Benzekry , Julien Nicolas

CRS 2024 Annual Meeting and Expo : integrating Delivery Science across disciplines, Jul 2024, Bologna, Italy

Poster de conférence hal-04719303v1

Long cell-free DNA fragments predict early-progression in patients with advanced or metastatic cancer treated with immune-checkpoint inhibition.

Sébastien Salas , Linh Nguyen Phuong , Jean-Charles Garcia , Laurent Greillier , Caroline Gaudy-Marqueste et al.

2024 ASCO annual meeting - American Society of Clinical Oncology Annual meeting 2024, May 2024, Chicago, United States. , Journal of clinical oncology, 42 (16_suppl), pp.e14550-e14550, 2024, ⟨10.1200/JCO.2024.42.16_suppl.e14550⟩

Poster de conférence hal-04717544v1
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Circulating cell-free DNA size distribution as a prediction marker for early progression undergoing immune checkpoint inhibitors

Linh Nguyen Phuong , Frederic Fina , Laurent Greillier , Caroline Gaudy-Marqueste , Jean-Laurent Deville et al.

PAGE 2024 - Annual meeting of the Population Approach Group Europe, Jun 2024, Rome, Italy

Poster de conférence hal-04665025v1

Long circulating-free DNA fragments predict early-progression (EP) and progression-free-survival (PFS) in advanced carcinoma treated with immune-checkpoint inhibition (ICI): a new biomarker

Sébastien Salas , Linh Nguyen Phuong , Frédéric Ginot , Laurent Greillier , Pascale Tomasini et al.

European Society for Medical Oncology Annual Meeting 2024, Sep 2024, Barcelone, Spain

Poster de conférence hal-04717549v1
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Quantitative cell-free DNA markers for prediction of early progression in patients undergoing immunotherapy

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia et al.

Summer School AI4Health, Jul 2023, Paris, France

Poster de conférence hal-04388821v1
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Quantitative cell-free DNA markers for prediction of early progression in patients undergoing immunotherapy

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia et al.

Department Days of the Cancer Research Cancer of Marseille, Jul 2023, Marseille, France

Poster de conférence hal-04388896v1
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Quantitative cell-free DNA markers for prediction of early progression in patients undergoing immunotherapy

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia et al.

Annual meeting of the Institute of Cancer and Immunologie of Marseille, Jun 2023, Marseille, France

Poster de conférence hal-04388796v1
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Machine learning for prediction of immunotherapy efficacy in nonsmall cell lung cancer from simple clinical and biological data

Sébastien Benzekry , Mathieu Grangeon , Mélanie Karlsen , Pauline Fleury , Maria Alexa et al.

WCoP 2022 - World Conference on Pharmacometrics, Mar 2022, Cape Town, South Africa

Poster de conférence hal-03935743v1
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A mechanistic model for prediction of metastatic relapse in early-stage breast cancer using routine clinical features

Célestin Bigarré , Pascal Finetti , François Bertucci , Xavier Muracciole , Sébastien Benzekry

AACR, Apr 2022, New Orléans, United States. Cancer Research, 82 (12), pp.2737, 2022, ⟨10.1158/1538-7445.AM2022-2737⟩

Poster de conférence hal-03752407v1
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Pharmacometrics modeling coupled with machine learning for early prediction of survival following atezolizumab monotherapy in non-small cell lung cancer

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , Suresh Vatakuti , Petter Curle et al.

Journée de la Recherche en Pharmacie, Oct 2022, Marseille, France

Poster de conférence hal-03935812v1
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Pharmacometrics modeling coupled with machine learning for early prediction of survival following atezolizumab monotherapy in non-small cell lung cancer

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , Suresh Vatakuti , Petter Curle et al.

compsyscan22 : A complex systems approach to cancer understanding, Oct 2022, Lyon, France

Poster de conférence hal-03935786v1

Comprehensive biomarkers analysis to explain resistances to PD1-L1 ICIs: The precision immuno-oncology for advanced non-small cell lung cancer (PIONeeR) trial

Laurent Greillier , Florence Monville , Vanina Leca , Frédéric Vely , Stephane Garcia et al.

2022 AACR annual meeting, Apr 2022, New Orleans, United States. , Cancer Research, 82 (12_Supplement), pp.LB120, 2022, ⟨10.1158/1538-7445.AM2022-LB120⟩

Poster de conférence hal-03926538v1
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Pharmacometrics modeling coupled with machine learning for early prediction of survival following atezolizumab monotherapy in non-small cell lung cancer

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , Suresh Vatakuti , Petter Curle et al.

World Conference on Pharmacometrics, Mar 2022, Cape Town, South Africa

Poster de conférence hal-03935768v1
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Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors

Anne Rodallec , Randy Lee , Sophie Marolleau , Sébastien Benzekry , Julien Nicolas

ESCDD, May 2022, Egmond aan Zee, Netherlands. 16, 2020, ⟨10.1371/journal.pcbi.1007178⟩

Poster de conférence hal-04726607v1
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Hijacked senescence secretomes as 'immune primers' of antiangiogenic TKI efficacy

Melissa Dolan , Yuhao Shi , James Hill , Michalis Mastri , Cristina Vaghi et al.

AACR 2021, Apr 2021, Virtual meeting, United States. 81 (13_Supplement), pp.3195-3195, 2021, ⟨10.1158/1538-7445.AM2021-3195⟩

Poster de conférence hal-04571502v1
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Machine Learning and Mechanistic Modeling for the prediction of Overall Survival on the basis of 1st line Tumor Dynamics in Head and Neck Squamous Cell Carcinoma

Kevin Atsou , Anne Auperin , Joêl Guigay , Sébastien Salas , Sébastien Benzekry

Colloque Science numériques et intelligence Artificielle pour la Santé, AMU, Nov 2021, Marseille, France

Poster de conférence hal-03467230v1
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Machine learning for prediction of immunotherapy efficacy in non-small cell lung cancer from simple clinical and biological data

Sébastien Benzekry , Mathieu Grangeon , Mélanie Karlsen , Pauline Fleury , Maria Alexa et al.

Colloque Sciences numériques et Intelligence Artificielle pour la Santé, Nov 2021, Marseille, France. 2021

Poster de conférence hal-03467615v1
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Population modeling of tumor growth curves, the reduced Gompertz model and prediction of the age of a tumor

Cristina Vaghi , Anne Rodallec , Raphaelle Fanciullino , Joseph Ciccolini , Jonathan Paul M. Mochel et al.

PAGE 2019 Twenty-eighth meeting, Jun 2019, Stockholm, Sweden

Poster de conférence hal-02424578v1
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Mathematical modeling of differential effects of neo-adjuvant Sunitinib on primary tumor and metastatic growth

Chiara Nicolò , Michalis Mastri , Amanda Tracz , John M.L. Ebos , Sébastien Benzekry

AACR Annual Meeting 2018, Apr 2018, Chicago, United States. 78 (13 Supplement), pp.4264, 2018, ⟨10.1158/1538-7445.AM2018-4264⟩

Poster de conférence hal-01968917v1
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A biologically-based mathematical model for prediction of metastatic relapse

Michalis Mastri , Cynthia Perier , Gaetan Macgrogan , John M.L. Ebos , Sébastien Benzekry

17th Biennial Congress of the Metastasis Research Society, Aug 2018, Princeton, United States

Poster de conférence hal-01968980v1
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Improving the efficacy of anti-cancer nanoparticles with data-driven mathematical modeling

Cristina Vaghi , Anne Rodallec , Raphaelle Fanciullino , Joseph Ciccolini , Clair Poignard et al.

Data Science Summer School, Jun 2018, Palaiseau, France

Poster de conférence hal-01968959v1
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Modeling Primary Tumor Dynamics of Human-to-Mouse Xenografted Non-Small Cell Lung Cancer in Response to Administration of Bevacizumab and Pemetrexed-Cisplatin

Benjamin Schneider , Arnaud Boyer , Joseph Ciccolini , Kenneth Wang , Martin E Fernandez-Zapico et al.

Population Approach Group in Europe (PAGE) Meeting 2018, May 2018, Montreux, Switzerland. 2018

Poster de conférence hal-01968942v1
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ROOFS: RObust biOmarker Feature Selection

Anastasiia Bakhmach , Paul Dufossé , Andrea Vaglio , Florence Monville , Laurent Greillier et al.

2026

Pré-publication, Document de travail hal-05241230v1
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The SChISM study: Circulating cell-free DNA size profiles as predictors of progression in advanced carcinoma treated with immune-checkpoint inhibitors

Linh Nguyen Phuong , Frederic Fina , Laurent Greillier , Pascale Tomasini , Jean-Laurent Deville et al.

2026

Pré-publication, Document de travail hal-05238567v3
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An integrative multimodal machine learning signature of primary resistance to immunotherapy in advanced non-small cell lung cancer: biomarker analysis from the PIONeeR study

Fabrice Barlesi , Florence Monville , Laurent Greillier , Natalie Ngoi , Joseph Ciccolini et al.

2025

Pré-publication, Document de travail hal-05241459v1
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Model-Driven Scheduling of Nanocarriers: Application to an Anticancer Polymer Prodrug Administered Subcutaneously

Anne Rodallec , Randy Lee , Jingming Cao , Sophie Marolleau , Julien Nicolas et al.

2025

Pré-publication, Document de travail hal-04937053v2
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Preclinical Pharmacokinetic-Pharmacodynamic Modeling of Antibody Nanoconjugates for Breast Cancer Treatment

Anne Rodallec , Cristina Vaghi , Joseph Ciccolini , Raphaëlle Fanciullino , Sébastien Benzekry

2025

Pré-publication, Document de travail hal-04937059v2
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Metamats: A mechanistic software for the simulation, inference and prediction of clinical metastasis

Célestin Bigarré , Alice Daumas , Laurent Greillier , Xavier Muracciole , Laeticia Padovani et al.

2025

Pré-publication, Document de travail hal-04935804v2
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Mechanistic Modeling of cfDNA Fragmentome Dynamics Predicts Progression to Immunotherapy

Linh Nguyen Phuong , Frédéric Fina , Laurent Greillier , Pascale Tomasini , Jean-Laurent Deville et al.

2025

Pré-publication, Document de travail hal-05241421v1

Large Language Models-guided Agentic Discovery of Imaging-informed Pharmacodynamic Models for Predicting Hematological Toxicity from Radioligand Therapy

Romain Ferrara , Victor Gertner , Adil Moussali , Solène Malmon , Louise Bouchard et al.

2025

Pré-publication, Document de travail hal-05241541v1
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Mechanistic Learning for Survival Prediction in NSCLC Using Routine Blood Biomarkers and Tumor Kinetics

Ruben Taieb , René Bruno , Pascal Chanu , Jin Yan Jin , Sébastien Benzekry

2025

Pré-publication, Document de travail hal-05241205v1
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Optimizing First-Line Therapeutics in Non-Small Cell Lung Cancer: Insights from Joint Modeling and Large-Scale Data Analysis

Benjamin Schneider , Sébastien Benzekry , Jonathan Mochel

2025

Pré-publication, Document de travail hal-04902176v1
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Mechanistic modeling of brain metastases in NSCLC provides computational markers for personalized prediction of outcome

Sebastien Benzekry , Pirmin Schlicke , Pascale Tomasini , Eleonore Simon

2023

Pré-publication, Document de travail hal-03935739v1
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Predicting survival and trial outcome in non-small cell lung cancer integrating tumor and blood markers kinetics with machine learning

Sébastien Benzekry , Mélanie Karlsen , Célestin Bigarré , Abdessamad El Kaoutari , Bruno Gomes et al.

2023

Pré-publication, Document de travail hal-04375606v1
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Mechanistic modeling of metastatic relapse in early breast cancer to investigate the biological impact of prognostic biomarkers

Célestin BIGARRÉ , François Bertucci , Pascal Finetti , Gaëtan Macgrogan , Xavier Muracciole et al.

2022

Pré-publication, Document de travail hal-03936594v1
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Comprehensive Joint Modeling of First-Line Therapeutics in Non-Small Cell Lung Cancer

Benjamin Schneider , Sébastien Benzekry , Jonathan Mochel

2024

Pré-publication, Document de travail hal-04387881v1
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A reduced Gompertz model for predicting tumor age using a population approach

Cristina Vaghi , Anne Rodallec , Raphaelle Fanciullino , Joseph Ciccolini , Jonathan Paul M. Mochel et al.

2019

Pré-publication, Document de travail hal-02165901v1
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Quantitative Analysis of the Tumor/Metastasis System and its Optimal Therapeutic Control

Sébastien Benzekry , Dominique Barbolosi , Assia Benabdallah , Florence Hubert , Philip Hahnfeldt

2012

Pré-publication, Document de travail hal-00836023v1
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Semaine d'Etude Mathématiques et Entreprises 1 : Deux problèmes sur les parcs solaires.

Nina Aguillon , Sebastien Benzekry , Jérémie Bettinelli , Pierre Bochard , Nicolas Bonnotte et al.

2011

Pré-publication, Document de travail hal-00710024v1
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Modeling, mathematical and numerical analysis of anti-cancerous therapies for metastatic cancers

Sébastien Benzekry

Analysis of PDEs [math.AP]. Université Aix-Marseille 1 – Université de Provence, 2011. English. ⟨NNT : ⟩

Thèse tel-01658210v1