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Sebastien Benzekry

Head of the Inria – Inserm project team COMPO (COMPutational pharmacology and clinical Oncology)
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Presentation

Sebastien Benzekry is a scientific researcher (PhD, HDR) at Inria, the french institute for applied mathematics, computer science and their applications. He has created (in 2021) and heads the Inria – Inserm (French national institute for biomedical research) project-team COMPO (COMPutational pharmacology and clinical Oncology), affiliated to both Inria and the Center for Research on Cancer of Marseille (Inserm U1068, CNRS UMR7258, Institut Paoli-Calmettes Institute, Aix-Marseille University, Faculty of Pharmacy). The objective of his research is to model data arising from (clinical) oncology in order to 1) bring clinical decision tools to enhance therapeutic management, 2) better inform and design clinical trials and 3) test biological hypotheses. To do so, he combines mechanistic (i.e., simulation models of the pharmaco-patho-physiological processes in cancer) and statistical learning through an approach termed 'mechanistic learning'. He has fifteen years of experience in trans-disciplinary projects in oncology, with a strong track record of publications in high impact journals (Cancer Res, PLoS Comp Biol, Clin Pharmacol Ther,...). His main topics of research are modeling metastatic development and immuno-oncology, integrating longitudinal data. These are implemented into code libraries developed with a focus on software development standards. Dr Benzekry has an initial training in applied mathematics (Ecole Normale Supérieure) followed by a PhD at Aix-Marseille University and further training in computational / systems biology as a postdoc in the Center for Cancer and Systems Biology, Tufts Univ, Boston, MA. Citations: 2095, h-index 24 (11/2011 – 03/2024), 50 research articles, 24 book chapters, editorials and proceedings. https://team.inria.fr/compo/ https://www-sop.inria.fr/members/Sebastien.Benzekry/index.html https://scholar.google.fr/citations?user=xsLpdFAAAAAJ&hl=fr&oi=ao

Publications

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A senescence-mimicking (senomimetic) VEGFR TKI side-effect primes tumor immune responses via IFN/STING signaling

Melissa Dolan , Yuhao Shi , Michalis Mastri , Mark Long , Amber Mckenery
Molecular Cancer Therapeutics, In press, Online ahead of print. ⟨10.1158/1535-7163.MCT-24-0139⟩
Journal articles hal-04571490v1
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Predicting Survival in Patients with Advanced NSCLC Treated with Atezolizumab Using Pre‐ and on‐Treatment Prognostic Biomarkers

Sébastien Benzekry , Mélanie Karlsen , Célestin Bigarré , Abdessamad El Kaoutari , Bruno Gomes
Clinical Pharmacology and Therapeutics, 2024, Online ahead of print. ⟨10.1002/cpt.3371⟩
Journal articles hal-04647230v1
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Machine-learning and mechanistic modeling of primary and metastatic breast cancer growth after neoadjuvant targeted therapy

Sébastien Benzekry , Michalis Mastri , Chiara Nicolò , John Ebos
PLoS Computational Biology, 2024, 20 (5), pp.e1012088. ⟨10.1371/journal.pcbi.1012088⟩
Journal articles hal-04384182v2

Computational markers for personalized prediction of outcomes in non-small cell lung cancer patients with brain metastases

Sébastien Benzekry , Pirmin Schlicke , Alice Mogenet , Laurent Greillier , Pascale Tomasini
Clinical and Experimental Metastasis, 2023, ⟨10.1007/s10585-023-10245-3⟩
Journal articles hal-04360487v1
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Mechanistic modeling of metastatic relapse in early breast cancer to investigate the biological impact of prognostic biomarkers

Célestin Bigarré , François Bertucci , Pascal Finetti , Gaëtan Macgrogan , Xavier Muracciole
Computer Methods and Programs in Biomedicine, 2023, 231, pp.107401. ⟨10.1016/j.cmpb.2023.107401⟩
Journal articles hal-04008520v1
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Reuniting philosophy and science to advance cancer research.

Thomas Pradeu , Bertrand Daignan-Fornier , Andrew Ewald , Pierre-Luc Germain , Samir Okasha
Biological Reviews, In press, ⟨10.1111/brv.12971⟩
Journal articles hal-04190936v1
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Tumor growth monitoring in breast cancer xenografts: A good technique for a strong ethic

Anne Rodallec , Cristina Vaghi , Joseph Ciccolini , Raphaëlle Fanciullino , Sebastien Benzekry
PLoS ONE, 2022, 17 (9), pp.e0274886. ⟨10.1371/journal.pone.0274886⟩
Journal articles hal-03924541v1
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Asymptotic analysis of a biphase tumor fluid flow: the weak coupling case.

Cristina Vaghi , Sébastien Benzekry , Clair Poignard
Applied Mathematics and Computation, 2022, 413, pp.126635. ⟨10.1016/j.amc.2021.126635⟩
Journal articles hal-03354766v2
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Practical identifiability analysis of a mechanistic model for the time to distant metastatic relapse and its application to renal cell carcinoma

Arturo Álvarez-Arenas , Wilfried Souleyreau , Andrea Emanuelli , Lindsay S Cooley , Jean-Christophe Bernhard
PLoS Computational Biology, 2022, 18, ⟨10.1371/journal.pcbi.1010444⟩
Journal articles hal-03921339v1
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Macro-scale models for fluid flow in tumour tissues: impact of microstructure properties

Cristina Vaghi , Raphaëlle Fanciullino , Sébastien Benzekry , Clair Poignard
Journal of Mathematical Biology, 2022, 84, pp.27. ⟨10.1007/s00285-022-01719-1⟩
Journal articles hal-02891573v1

Des modèles mathématiques pour la recherche clinique en cancérologie

Sébastien Benzekry
Interstices, 2022, ⟨10.60527/7cky-8075⟩
Journal articles hal-03746564v1
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Machine Learning for Prediction of Immunotherapy Efficacy in Non-Small Cell Lung Cancer from Simple Clinical and Biological Data

Sébastien Benzekry , Mathieu Grangeon , Mélanie Karlsen , Maria Alexa , Isabella Bicalho-Frazeto
Cancers, 2021, 13 (24), pp.6210. ⟨10.3390/cancers13246210⟩
Journal articles hal-03478003v2
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Development and Validation of a Prediction Model of Overall Survival in High-Risk Neuroblastoma Using Mechanistic Modeling of Metastasis

Sébastien Benzekry , Coline Sentis , Carole Coze , Laëtitia Tessonnier , Nicolas André
JCO Clinical Cancer Informatics, 2021, 5, pp.81-90. ⟨10.1200/CCI.20.00092⟩
Journal articles hal-03147049v1

Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression

Lindsay Cooley , Justine Rudewicz , Wilfried Souleyreau , Andrea Emanuelli , Arturo Alvarez-Arenas
Molecular Cancer, 2021, 20 (1), ⟨10.1186/s12943-021-01416-5⟩
Journal articles hal-03390517v1
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Artificial Intelligence and Mechanistic Modeling for Clinical Decision Making in Oncology

Sébastien Benzekry
Clinical Pharmacology and Therapeutics, 2020, ⟨10.1002/cpt.1951⟩
Journal articles hal-02916941v1
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Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors

Cristina Vaghi , Anne Rodallec , Raphaëlle Fanciullino , Joseph Ciccolini , Jonathan P Mochel
PLoS Computational Biology, 2020, 16 (2), pp.e1007178. ⟨10.1371/journal.pcbi.1007178⟩
Journal articles inserm-02515955v1
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Machine Learning and Mechanistic Modeling for Prediction of Metastatic Relapse in Early-Stage Breast Cancer

Chiara Nicolò , Cynthia Périer , Mélanie Prague , Carine Bellera , Gaëtan Macgrogan
JCO Clinical Cancer Informatics, 2020, 4, pp.259-274. ⟨10.1200/CCI.19.00133⟩
Journal articles hal-02942177v1
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Prédiction de l'efficacité de l'immunothérapie dans le cancer bronchique à partir de données cliniques et biologiques simples : apport de l'intelligence artificielle

Mathieu Grangeon , Sebastien Benzekry , Solène Chaleat , Pascale Tomasini , Dominique Barbolosi
Revue des Maladies Respiratoires Actualites, 2020, 12 (1), pp.217. ⟨10.1016/j.rmra.2019.11.477⟩
Journal articles hal-03147118v1
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Mechanistic Learning for Combinatorial Strategies With Immuno-oncology Drugs: Can Model-Informed Designs Help Investigators?

Joseph Ciccolini , Dominique Barbolosi , Nicolas André , Fabrice Barlesi , Sébastien Benzekry
JCO precision oncology, 2020, 108 (4), pp.486-491. ⟨10.1200/PO.19.00381⟩
Journal articles hal-03147084v1
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Deciphering the response and resistance to immunecheckpoint inhibitors in lung cancer with artificial intelligence-based analysis: the pioneer and quantic joint-projects

Joseph Ciccolini , Sébastien Benzekry , Fabrice Barlesi
British Journal of Cancer, 2020, 123 (3), pp.337-338. ⟨10.1038/s41416-020-0918-3⟩
Journal articles hal-03147110v1
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Is There Any Room for Pharmacometrics With Immuno-Oncology Drugs? Input from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

Anne Rodallec , Raphaelle Fanciullino , Sébastien Benzekry , Joseph Ciccolini
Anticancer Research, 2019, 39 (7), pp.3419-3422. ⟨10.21873/anticanres.13486⟩
Journal articles hal-02383831v1
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CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies

Jonathan Paul M. Mochel , Stephen C Ekker , Chad Johannes , Albert E Jergens , Karin Allenspach
AAPS Journal, 2019, 21 (3), ⟨10.1208/s12248-019-0322-1⟩
Journal articles hal-02099159v1
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Quantitative mathematical modeling of clinical brain metastasis dynamics in non-small cell lung cancer

Maria Bilous , Cindy Serdjebi , Arnaud Boyer , Claudia Pouypoudat , Pascale Tomasini
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-49407-3⟩
Journal articles hal-01928442v2
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Optimal Scheduling of Bevacizumab and Pemetrexed/cisplatin Dosing in Non‐Small Cell Lung Cancer

Benjamin K Schneider , Arnaud Boyer , Joseph Ciccolini , Fabrice Barlesi , Kenneth Wang
CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12415⟩
Journal articles hal-02109335v1
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Combinatorial immunotherapy strategies : most gods throw dice, but fate plays chess

Joseph Ciccolini , Dominique Barbolosi , Nicolas Andre , Sébastien Benzekry , Fabrice Barlesi
Annals of Oncology, 2019, ⟨10.1093/annonc/mdz297⟩
Journal articles hal-02383826v1
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Combinatorial immunotherapy strategies: most gods throw dice, but fate

Joseph Ciccolini , Dominique Barbolosi , Nicolas André , Sebastien Benzekry , Fabrice Barlesi
Annals of Oncology, 2019, 30 (11), pp.1690-1691. ⟨10.1093/annonc/mdz297/5559268⟩
Journal articles hal-03147132v1
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Revisiting bevacizumab + cytotoxics scheduling using mathematical modeling: proof of concept study in experimental non-small cell lung carcinoma

Diane-Charlotte Imbs , Raouf El Cheikh , Arnaud Boyer , Joseph Ciccolini , Celine Mascaux
CPT: Pharmacometrics and Systems Pharmacology, 2018, pp.1-9. ⟨10.1002/psp4.12265⟩
Journal articles hal-01624423v2
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Pharmacokinetics variability: why nanoparticles are not magic bullets in oncology

Anne Rodallec , Sébastien Benzekry , Bruno Lacarelle , Joseph Ciccolini , Raphaelle Fanciullino
Critical Reviews in Oncology/Hematology, 2018, 129, pp.1 - 12. ⟨10.1016/j.critrevonc.2018.06.008⟩
Journal articles hal-01821678v1
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Turning cold tumors into hot tumors: harnessing the potential of tumor immunity using nanoparticles

Anne Rodallec , Guillaume Sicard , Raphaelle Fanciullino , Sébastien Benzekry , Bruno Lacarelle
Expert Opinion on Drug Metabolism and Toxicology, 2018, 14 (11), pp.1-9. ⟨10.1080/17425255.2018.1540588⟩
Journal articles hal-01958583v1
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Model-driven optimization of antiangiogenics + cytotoxics combination: application to breast cancer mice treated with bevacizumab + paclitaxel doublet leads to reduced tumor growth and fewer metastasis

Severine Mollard , Joseph Ciccolini , Diane-Charlotte Imbs , Raouf El Cheikh , Dominique Barbolosi
Journal articles hal-01474679v1

Etude de l'effet séquence bevacizumab/pemetrexed/cisplatine chez la souris porteuse de cancer du poumon non à petites cellules

Arnaud Boyer , Joseph Ciccolini , Céline Mascaux , Diane-Charlotte Imbs , Raouf El Cheikh
Revue des Maladies Respiratoires, 2017, 34, ⟨10.1016/j.rmr.2016.10.110⟩
Journal articles hal-01540322v1
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Mathematical modeling of tumor-tumor distant interactions supports a systemic control of tumor growth

Sébastien Benzekry , Clare Lamont , Dominique Barbolosi , Lynn Hlatky , Philip Hahnfeldt
Journal articles hal-01566947v1
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Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas

Araceli M Henares-Molina , Sébastien Benzekry , Pedro C Lara , Marcial M García-Rojo , Víctor M Pérez-García
Journal articles hal-01532505v1

Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach

Madeleine Benguigui , Dror Alishekevitz , Michael Timaner , Dvir Shechter , Ziv Raviv
Oncotarget, 2017, 9 (2), pp.2574-2590. ⟨10.18632/oncotarget.23514⟩
Journal articles hal-01672568v1
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Next generation metronomic chemotherapy - report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6 - 8 May 2016, Mumbai

Pan G Pantziarka , Lisa Hutchinson , Nicolas G André , Sébastien Benzekry , Francesco Bertolini
Ecancermedicalscience, 2016, 10, ⟨10.3332/ecancer.2016.689⟩
Journal articles hal-01392473v1
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Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach

Sébastien Benzekry , Amanda Tracz , Michalis Mastri , R. Corbelli , Dominique Barbolosi
Cancer Research, 2016, 76 (3), pp.535 - 547. ⟨10.1158/0008-5472.CAN-15-1389⟩
Journal articles hal-01222046v2
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In Vivo Bioluminescence Tomography for Monitoring Breast Tumor Growth and Metastatic Spreading: Comparative Study and Mathematical Modeling

Séverine Mollard , Raphaelle Fanciullino , Sarah Giacometti , Cindy Serdjebi , Sebastien Benzekry
Scientific Reports, 2016, 6, pp.10. ⟨10.1038/srep36173⟩
Journal articles hal-01392861v1
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Les lois de la croissance tumorale

Sébastien Benzekry
Bibliothèque Tangente, 2016
Journal articles hal-01418295v1

Mathematical modeling of cancer immunotherapy and its synergy with radiotherapy

R. Serre , Sébastien Benzekry , Laetitia Padovani , C. Meille , N. Andre
Journal articles hal-01336779v1

Improving efficacy of the combination between antiangiogenic and chemotherapy: Time for mathematical modeling support

Joseph Ciccolini , Sébastien Benzekry , Bruno Lacarelle , Dominique Barbolosi , Fabrice Barlesi
Proceedings of the National Academy of Sciences of the United States of America, 2015, pp.1. ⟨10.1073/pnas.1506689112⟩
Journal articles hal-01168635v1

Host Age Is a Systemic Regulator of Gene Expression Impacting Cancer Progression

Afshin Beheshti , Sebastien Benzekry , J. Tyson Mcdonald , Lili Ma , Michael Peluso
Cancer Research, 2015, 75 (6), pp.10. ⟨10.1158/0008-5472.CAN-14-1053⟩
Journal articles hal-01132048v1
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Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks

Sebastien Benzekry , Jack A Tuszynski , Edward A Rietman , Giannoula Lakka Klement
Biology Direct, 2015, pp.14. ⟨10.1186/s13062-015-0058-5⟩
Journal articles hal-01158313v1
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Metronomic Reloaded: Theoretical Models Bringing Chemotherapy into the Era of Precision Medicine

Sébastien Benzekry , Eddy Pasquier , Dominique Barbolosi , Bruno Lacarelle , Fabrice Barlési
Seminars in Cancer Biology, 2015, pp.23. ⟨10.1016/j.semcancer.2015.09.002⟩
Journal articles hal-01195547v1
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Computational Modelling of Metastasis Development in Renal Cell Carcinoma

Etienne Baratchart , Sébastien Benzekry , Andreas Bikfalvi , Thierry Colin , Lindsay S. Cooley
PLoS Computational Biology, 2015, 11 (11), ⟨10.1371/journal.pcbi.1004626⟩
Journal articles hal-01164834v2
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Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth

Sebastien Benzekry , Afshin Beheshti , Philip Hahnfeldt , Lynn Hlatky
Bio-protocol , 2015, 5 (21)
Journal articles hal-01222068v1
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Global Dormancy of Metastases due to Systemic Inhibition of Angiogenesis

Sébastien Benzekry , Alberto Gandolfi , Philip Hahnfeldt
PLoS ONE, 2014, 9 (1), pp.e84249. ⟨10.1371/journal.pone.0084249⟩
Journal articles hal-00868592v3
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Classical Mathematical Models for Description and Forecast of Experimental Tumor Growth

Sébastien Benzekry , Clare Lamont , Afshin Beheshti , Amanda Tracz , John M.L. Ebos
PLoS Computational Biology, 2014, 10 (8), pp.e1003800. ⟨10.1371/journal.pcbi.1003800⟩
Journal articles hal-00922553v6
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Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers.

Sebastien Benzekry , Philip Hahnfeldt
Journal of Theoretical Biology, 2013, 335, pp.235-44. ⟨10.1016/j.jtbi.2013.06.036⟩
Journal articles hal-00836032v1

Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice.

Floriane Lignet , Sébastien Benzekry , Shelby Wilson , Frédérique Billy , Olivier Saut
Journal of Theoretical Biology, 2013, 320, pp.86-99. ⟨10.1016/j.jtbi.2012.12.013⟩
Journal articles hal-00785876v1
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A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology

Sébastien Benzekry , Guillemette Chapuisat , Joseph Ciccolini , Alice Erlinger , Florence Hubert
Comptes rendus de l'Académie des sciences. Série I, Mathématique, 2012, 350, pp.23-28. ⟨10.1016/j.crma.2011.11.019⟩
Journal articles hal-00641476v2
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Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers

Sebastien Benzekry
ESAIM: Mathematical Modelling and Numerical Analysis, 2012, 46 (2), pp.207-237
Journal articles hal-00518110v1
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Modeling the impact of anticancer agents on metastatic spreading

Sébastien Benzekry , Nicolas André , Assia Benabdallah , Joseph Ciccolini , Christian Faivre
Mathematical Model Natural Phenomenon, 2012, 7 (1), pp 306--336. ⟨10.1051/mmnp/20127114⟩
Journal articles hal-00657724v1
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Passing to the limit 2D-1D in a model for metastatic growth

Sebastien Benzekry
Journal of Biological Dynamics, 2011, pp.10.1080/17513758.2011.568071. ⟨10.1080/17513758.2011.568071⟩
Journal articles hal-00521968v1
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Mathematical analysis of a two-dimensional population model of metastatic growth including angiogenesis

Sebastien Benzekry
Journal of Evolution Equations, 2011, 11 (1), pp.187-213
Journal articles hal-00516693v1

Mathematical modeling of routine biological parameters kinetics in order to predict durable benefit for first-line immunotherapy in metastatic or unresectable melanoma.

Jessica Forestier , Alice Julie Daumas , Marie-Aleth Richard , Caroline Gaudy-Marqueste , Sébastien Benzekry
2024 ASCO Annual Meeting, Jun 2024, Chicago (USA), United States. pp.e21549-e21549, ⟨10.1200/jco.2024.42.16_suppl.e21549⟩
Conference papers hal-04713615v1

Long cell-free DNA fragments predict early-progression in patients with advanced or metastatic cancer treated with immune-checkpoint inhibition.

Sébastien Salas , Linh Nguyen Phuong , Jean-Charles Garcia , Laurent Greillier , Caroline Gaudy-Marqueste
2024 ASCO annual meeting - American Society of Clinical Oncology Annual meeting 2024, American Society of Clinical Oncology, May 2024, Chicago, United States. pp.e14550-e14550, ⟨10.1200/JCO.2024.42.16_suppl.e14550⟩
Conference papers hal-04717544v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry
2024 Annual conference of the Society of Mathematical Biology, Korean Society of Mathematical Biology, Jul 2024, Seoul, South Korea
Conference papers hal-04647234v1

Integrating tumor kinetics and circulating cell-free DNA markers through mechanistic modeling for early prediction of immunotherapy response

Linh Nguyen Phuong , Frederic Fina , Laurent Greillier , Caroline Gaudy-Marqueste , Jean-Laurent Deville
KSMB-SMB 2024 - Joint annual meeting of the Korean Society for Mathematical Biology and the Society for Mathematical Biology, Jul 2024, Seoul, South Korea
Conference papers hal-04665038v1

Artificial intelligence in healthcare data warehouses

Sébastien Benzekry
Annual congress of the French group of clinical pneumo-oncology (GPCO), Jun 2023, Toulon, France
Conference papers hal-04388413v1

Using statistical learning for clinical trials

Sébastien Benzekry
Annual meeting of the APHM center for early phase clinical trials in oncology, Jun 2023, Marseille, France
Conference papers hal-04388605v1
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Une comparaison des algorithmes d'apprentissage pour la survie avec données manquantes

Paul Dufossé , Sébastien Benzekry
JDS 2023 - 54e Journées de Statistique de la SFds, SFdS, Jul 2023, Bruxelles (BEL), Belgique. ⟨10.48550/arXiv.2303.13590⟩
Conference papers hal-04384220v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry
SMAI 2023 congress - 11th French Biennial of Applied and Industrial Mathematics, May 2023, Le Gosier (Guadeloupe), France
Conference papers hal-04388478v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry
CARe graduate school workshop, Jan 2023, Toulouse, France
Conference papers hal-04388750v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry
Workshop for young researchers in Cancer 2023, Cancéropôle PACA, Oct 2023, Porquerolles, France
Conference papers hal-04388572v1

Mechanistic modeling of the longitudinal tumor and biological markers combined with quantitative cell-free DNA

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia
2023 SMB annual meeting - Annual Meeting of the Society for Mathematical Biology, Society for Mathematical Biology, Jul 2023, Columbus (Ohio), United States
Conference papers hal-04388020v1

Integrative kinetics and machine learning modeling for prediction of outcome following immunotherapy in lung cancer

Sébastien Benzekry
Annual congress of the French society of pharmacology and therapeutics (SFPT), Jun 2023, Limoges, France
Conference papers hal-04388499v1
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Supporting decision making and early prediction of survival for oncology drug development using a pharmacometrics-machine learning based model

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , René Bruno , Aleš Neubert
PAGE - Population Approach Group Europe, Jun 2022, Ljubljana, Slovenia
Conference papers hal-03921394v1

Comprehensive biomarkers analysis to explain resistances to PD1-L1 ICIs: The precision immuno-oncology for advanced non-small cell lung cancer (PIONeeR) trial

Laurent Greillier , Florence Monville , Vanina Leca , Frédéric Vely , Stephane Garcia
2022 AACR annual meeting, AACR, Apr 2022, New Orleans, United States. pp.LB120, ⟨10.1158/1538-7445.AM2022-LB120⟩
Conference papers hal-03926538v1
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Pharmacometrics modeling coupled with machine learning for early prediction of survival following atezolizumab monotherapy in non-small cell lung cancer

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , Suresh Vatakuti , Petter Curle
World Conference on Pharmacometrics, Mar 2022, Cape Town, South Africa
Conference papers hal-03935768v1
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A mechanistic model for prediction of metastatic relapse in early-stage breast cancer using routine clinical features

Célestin Bigarré , Pascal Finetti , François Bertucci , Xavier Muracciole , Sébastien Benzekry
AACR, Apr 2022, New Orléans, United States. pp.2737, ⟨10.1158/1538-7445.AM2022-2737⟩
Conference papers hal-03752407v1
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Machine learning for prediction of immunotherapy efficacy in nonsmall cell lung cancer from simple clinical and biological data

Sébastien Benzekry , Mathieu Grangeon , Mélanie Karlsen , Pauline Fleury , Maria Alexa
WCoP 2022 - World Conference on Pharmacometrics, Mar 2022, Cape Town, South Africa
Conference papers hal-03935743v1
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3MO - Comprehensive biomarkers (BMs) analysis to predict efficacy of PD1/L1 immune checkpoint inhibitors (ICIs) in combination with chemotherapy: a subgroup analysis of the Precision Immuno-Oncology for advanced Non-Small CEll Lung CancER (PIONeeR) trial

Fabrice Barlesi , Laurent Greillier , Florence Monville , C Audigier-Valette , S. Martinez
2022 ESMO Immuno-Oncology Congress, Dec 2022, Geneva, Switzerland
Conference papers hal-03928784v1
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Machine learning versus mechanistic modeling for prediction of metastatic relapse in breast cancer

Sebastien Benzekry
2019 CSBC-PSON Mathematical Oncology Meeting, May 2019, Portland, United States
Conference papers hal-02424419v1
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Data-driven mechanistic modeling of metastasis: cancer at the organism scale

Sébastien Benzekry
RITS conference (Recherche en Imagerie et Technologies pour la Sante) of the French Society of Biomedical Engineering (SFGBM), May 2019, Tours, France
Conference papers hal-02424452v2
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Mechanistic modeling of metastasis: cancer at the organism scale

Sébastien Benzekry
International Society of Pharmacometrics (ISoP) workshop, Jul 2019, Paris, France
Conference papers hal-02424424v1
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Mathematical Modeling of Tumor-Tumor Distant Interactions Supports a Systemic Control of Tumor Growth

Sébastien Benzekry
3rd Mathematical Biology Modeling days of Besançon, Jun 2018, Besançon, France
Conference papers hal-01969102v1
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Optimization of sequential administration of bevacizumab plus cytotoxics in non-small cell lung cancer by combining in vivo experiments and mathematical modeling

Sébastien Benzekry
Mathematical perspectives in the biology and therapeutics of cancer, Jul 2018, Marseille, France
Conference papers hal-01969142v1
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Mathematical Modeling and Prediction of Clinical Metastasis

Sébastien Benzekry
Mathematical Challenges in the Analysis of Continuum Models for Cancer Growth, Evolution and Therapy, Nov 2018, Oaxaca, Mexico
Conference papers hal-01969108v1

Optimized radiotherapy protocols delay the malignant transformation of low-grade gliomas in-silico

Araceli Henares-Molina , Sébastien Benzekry , Pedro Lara , Marcial García-Rojo , Victor Pérez-García
5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies, May 2017, Zurich, Switzerland. pp.iii12 - iii12, ⟨10.1093/neuonc/nox036.040⟩
Conference papers hal-01517899v1

Abstract 2099: Model-driven optimization of anti-angiogenics combined with chemotherapy: application to bevacizumab + pemetrexed/cisplatin doublet in NSCLC-bearing mice

Joseph Ciccolini , Sebastien Benzekry , Sarah Giacometti , Fabrice Barlesi , Dominique Barbolosi
107th Annual Meeting of the American Association for Cancer Research, 2016, New Orleans, France. pp.20, ⟨10.1158/1538-7445.AM2016-2099⟩
Conference papers hal-01404637v1
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On the growth and dissemination laws in a mathematical model of metastatic growth

Sébastien Benzekry , John M.L. Ebos
Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500007⟩
Conference papers hal-01222088v1

Model-based optimization of combined antiangiogenic + cytotoxics modalities: application to the bevacizumab-paclitaxel association in breast cancer models

Séverine Mollard , Sébastien Benzekry , Giacometti Sarah , Christian Faivre , Florence Hubert
AACR Annual Meeting 2014, Apr 2014, San Diego, United States. ⟨10.1158/1538-7445.AM2014-3677⟩
Conference papers hal-01090883v1
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A mathematical model of systemic inhibition of angiogenesis in metastatic development

Sébastien Benzekry , Alberto Gandolfi , Philip Hahnfeldt
Congres SMAI 2013, May 2013, Seignosse, France. pp.75-87, ⟨10.1051/proc/201445008⟩
Conference papers hal-00867992v1
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PK/PD modelling to advance the preclinical development of a novel polymer prodrug in oncology

Anne Rodallec , Randy Lee , Sophie Marolleau , Sébastien Benzekry , Julien Nicolas
CRS 2024 Annual Meeting and Expo : integrating Delivery Science across disciplines, Jul 2024, Bologna, Italy
Conference poster hal-04719303v1
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Long circulating-free DNA fragments predict early-progression (EP) and progression-free-survival (PFS) in advanced carcinoma treated with immune-checkpoint inhibition (ICI): a new biomarker

Sébastien Salas , Linh Nguyen Phuong , Frédéric Ginot , Laurent Greillier , Pascale Tomasini
European Society for Medical Oncology Annual Meeting 2024, Sep 2024, Barcelone, Spain
Conference poster hal-04717549v1
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Circulating cell-free DNA size distribution as a prediction marker for early progression undergoing immune checkpoint inhibitors

Linh Nguyen Phuong , Frederic Fina , Laurent Greillier , Caroline Gaudy-Marqueste , Jean-Laurent Deville
PAGE 2024 - Annual meeting of the Population Approach Group Europe, Jun 2024, Rome, France. ⟨10.1016/j.cell.2017.01.017⟩
Conference poster hal-04665025v1
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Quantitative cell-free DNA markers for prediction of early progression in patients undergoing immunotherapy

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia
Summer School AI4Health, Jul 2023, Paris, France
Conference poster hal-04388821v1
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Quantitative cell-free DNA markers for prediction of early progression in patients undergoing immunotherapy

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia
Annual meeting of the Institute of Cancer and Immunologie of Marseille, Jun 2023, Marseille, France
Conference poster hal-04388796v1
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Quantitative cell-free DNA markers for prediction of early progression in patients undergoing immunotherapy

Linh Nguyen Phuong , Laurent Greillier , Caroline Gaudy , Jean-Laurent Deville , Jean-Charles Garcia
Department Days of the Cancer Research Cancer of Marseille, Jul 2023, Marseille, France
Conference poster hal-04388896v1
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Pharmacometrics modeling coupled with machine learning for early prediction of survival following atezolizumab monotherapy in non-small cell lung cancer

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , Suresh Vatakuti , Petter Curle
Journée de la Recherche en Pharmacie, Oct 2022, Marseille, France
Conference poster hal-03935812v1
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Pharmacometrics modeling coupled with machine learning for early prediction of survival following atezolizumab monotherapy in non-small cell lung cancer

Sébastien Benzekry , Mélanie Karlsen , Abdessamad Elkaoutari , Suresh Vatakuti , Petter Curle
compsyscan22 : A complex systems approach to cancer understanding, Oct 2022, Lyon, France
Conference poster hal-03935786v1
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Hijacked senescence secretomes as 'immune primers' of antiangiogenic TKI efficacy

Melissa Dolan , Yuhao Shi , James Hill , Michalis Mastri , Cristina Vaghi
AACR 2021, Apr 2021, Virtual meeting, United States. 81 (13_Supplement), pp.3195-3195, 2021, ⟨10.1158/1538-7445.AM2021-3195⟩
Conference poster hal-04571502v1
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Machine Learning and Mechanistic Modeling for the prediction of Overall Survival on the basis of 1st line Tumor Dynamics in Head and Neck Squamous Cell Carcinoma

Kevin Atsou , Anne Auperin , Joêl Guigay , Sébastien Salas , Sébastien Benzekry
Colloque Science numériques et intelligence Artificielle pour la Santé, AMU, Nov 2021, Marseille, France
Conference poster hal-03467230v1
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Machine learning for prediction of immunotherapy efficacy in non-small cell lung cancer from simple clinical and biological data

Sébastien Benzekry , Mathieu Grangeon , Mélanie Karlsen , Pauline Fleury , Maria Alexa
Colloque Sciences numériques et Intelligence Artificielle pour la Santé à Aix-Marseille Université, Nov 2021, Marseille, France. 2021
Conference poster hal-03467615v1
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Population modeling of tumor growth curves, the reduced Gompertz model and prediction of the age of a tumor

Cristina Vaghi , Anne Rodallec , Raphaelle Fanciullino , Joseph Ciccolini , Jonathan Paul M. Mochel
PAGE 2019 Twenty-eighth meeting, Jun 2019, Stockholm, Sweden
Conference poster hal-02424578v1
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Mathematical modeling of differential effects of neo-adjuvant Sunitinib on primary tumor and metastatic growth

Chiara Nicolò , Michalis Mastri , Amanda Tracz , John M.L. Ebos , Sébastien Benzekry
AACR Annual Meeting 2018, Apr 2018, Chicago, United States. 78 (13 Supplement), pp.4264, 2018, ⟨10.1158/1538-7445.AM2018-4264⟩
Conference poster hal-01968917v1
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A biologically-based mathematical model for prediction of metastatic relapse

Michalis Mastri , Cynthia Perier , Gaetan Macgrogan , John M.L. Ebos , Sébastien Benzekry
17th Biennial Congress of the Metastasis Research Society, Aug 2018, Princeton, United States
Conference poster hal-01968980v1
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Modeling Primary Tumor Dynamics of Human-to-Mouse Xenografted Non-Small Cell Lung Cancer in Response to Administration of Bevacizumab and Pemetrexed-Cisplatin

Benjamin Schneider , Arnaud Boyer , Joseph Ciccolini , Kenneth Wang , Martin E Fernandez-Zapico
Population Approach Group in Europe (PAGE) Meeting 2018, May 2018, Montreux, Switzerland. 2018
Conference poster hal-01968942v1
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Improving the efficacy of anti-cancer nanoparticles with data-driven mathematical modeling

Cristina Vaghi , Anne Rodallec , Raphaelle Fanciullino , Joseph Ciccolini , Clair Poignard
Data Science Summer School, Jun 2018, Palaiseau, France
Conference poster hal-01968959v1
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Computational modeling for circulating cell-free DNA in clinical oncology

Linh Nguyen Phuong , Sébastien Salas , Sébastien Benzekry
2024
Preprints, Working Papers, ... hal-04481689v3
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Comprehensive Joint Modeling of First-Line Therapeutics in Non-Small Cell Lung Cancer

Benjamin Schneider , Sébastien Benzekry , Jonathan Mochel
2024
Preprints, Working Papers, ... hal-04387881v1
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Tumor kinetics modeling outperforms best overall response for prediction of survival in head and neck squamous cell carcinoma

Kevin Atsou , Anne Auperin , Joël Guigay , Sébastien Salas , Sébastien Benzekry
2024
Preprints, Working Papers, ... hal-04558029v1
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Mechanistic modeling of brain metastases in NSCLC provides computational markers for personalized prediction of outcome

Sebastien Benzekry , Pirmin Schlicke , Pascale Tomasini , Eleonore Simon
2023
Preprints, Working Papers, ... hal-03935739v1
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Predicting survival and trial outcome in non-small cell lung cancer integrating tumor and blood markers kinetics with machine learning

Sébastien Benzekry , Mélanie Karlsen , Célestin Bigarré , Abdessamad El Kaoutari , Bruno Gomes
2023
Preprints, Working Papers, ... hal-04375606v1
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Acquired resistance to PD-L1 inhibition is associated with an enhanced type I IFN-stimulated secretory program in tumor cells

Yuhao Shi , Melissa Dolan , Michalis Mastri , Amber Mckenery , James W Hill
2023
Preprints, Working Papers, ... hal-04387866v1
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Mechanistic modeling of metastatic relapse in early breast cancer to investigate the biological impact of prognostic biomarkers

Célestin BIGARRÉ , François Bertucci , Pascal Finetti , Gaëtan Macgrogan , Xavier Muracciole
2022
Preprints, Working Papers, ... hal-03936594v1
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A reduced Gompertz model for predicting tumor age using a population approach

Cristina Vaghi , Anne Rodallec , Raphaelle Fanciullino , Joseph Ciccolini , Jonathan Paul M. Mochel
2019
Preprints, Working Papers, ... hal-02165901v1
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Quantitative Analysis of the Tumor/Metastasis System and its Optimal Therapeutic Control

Sébastien Benzekry , Dominique Barbolosi , Assia Benabdallah , Florence Hubert , Philip Hahnfeldt
2012
Preprints, Working Papers, ... hal-00836023v1
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Semaine d'Etude Mathématiques et Entreprises 1 : Deux problèmes sur les parcs solaires.

Nina Aguillon , Sebastien Benzekry , Jérémie Bettinelli , Pierre Bochard , Nicolas Bonnotte
2011
Preprints, Working Papers, ... hal-00710024v1
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Modeling, mathematical and numerical analysis of anti-cancerous therapies for metastatic cancers

Sébastien Benzekry
Analysis of PDEs [math.AP]. Université Aix-Marseille 1 – Université de Provence, 2011. English. ⟨NNT : ⟩
Theses tel-01658210v1
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Contributions in Mathematical Oncology: When Theory Meets Reality

Sébastien Benzekry
Mathematics [math]. Université de Bordeaux, 2017
Habilitation à diriger des recherches tel-01658070v1