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Sébastien Besseau

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Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast

Thomas Perrot , Jillian Marc , Enzo Lezin , Nicolas Papon , Sébastien Besseau
Current Opinion in Biotechnology, 2024, 87, pp.103098. ⟨10.1016/j.copbio.2024.103098⟩
Article dans une revue hal-04501078v1

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast

Samuel Bradley , Beata Lehka , Frederik Hansson , Khem Adhikari , Daniela Rago
Nature Chemical Biology, 2023, 19 (12), pp.1551-1560. ⟨10.1038/s41589-023-01430-2⟩
Article dans une revue hal-04440255v1
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Terroir Influence on Polyphenol Metabolism from Grape Canes: A Spatial Metabolomic Study at Parcel Scale

Kévin Billet , Sébastien Salvador-Blanes , Thomas Dugé de Bernonville , Guillaume Delanoue , Florent Hinschberger
Molecules, 2023, 28 (11), pp.4555. ⟨10.3390/molecules28114555⟩
Article dans une revue hal-04122051v1

The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids

Emily Amor Stander , Beata Lehka , Inês Carqueijeiro , Clément Cuello , Frederik Hansson
Communications Biology, 2023, 6 (1), pp.1197. ⟨10.1038/s42003-023-05574-8⟩
Article dans une revue hal-04330724v1

Boosting lignan-precursor synthesis in yeast cell factories through co-factor supply optimization

Jennifer Perrin , Sebastien Besseau , Nicolas Papon , Vincent Courdavault
Frontiers in Bioengineering and Biotechnology, 2022, 10, ⟨10.3389/fbioe.2022.1079801⟩
Article dans une revue hal-03916793v1

Tonoplast and Peroxisome Targeting of γ-tocopherol N -methyltransferase Homologs Involved in the Synthesis of Monoterpene Indole Alkaloids

Konstantinos Koudounas , Gregory Guirimand , Luisa Fernanda Rojas Hoyos , Ines Carqueijeiro , Pamela Lemos Cruz
Plant and Cell Physiology, 2022, ⟨10.1093/pcp/pcab160⟩
Article dans une revue hal-03430222v1

Genome assembly of the medicinal plant Voacanga thouarsii

Clément Cuello , Emily Amor Stander , Hans Jansen , Thomas Dugé de Bernonville , Arnaud Lanoue
Genome Biology and Evolution, 2022, ⟨10.1093/gbe/evac158⟩
Article dans une revue hal-03833558v1
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Consecutive action of two BAHD acyltransferases promotes tetracoumaroyl spermine accumulation in chicory

Guillaume Bernard , Julie Buges , Marianne Delporte , Roland Molinié , Sebastien Besseau
Plant Physiology, 2022, ⟨10.1093/plphys/kiac234⟩
Article dans une revue hal-03692347v1

Exploiting Spermidine N -Hydroxycinnamoyltransferase Diversity and Substrate Promiscuity to Produce Various Trihydroxycinnamoyl Spermidines and Analogues in Engineered Yeast

Jennifer Perrin , Natalja Kulagina , Marianne Unlubayir , Thibaut Munsch , Inês Carqueijeiro
ACS Synthetic Biology, 2021, 10 (2), pp.286-296. ⟨10.1021/acssynbio.0c00391⟩
Article dans une revue hal-03287505v1

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Pamela Lemos Cruz , Natalja Kulagina , Grégory Guirimand , Johan-Owen de Craene , Sébastien Besseau
Molecules, 2021, 26 (12), pp.3596. ⟨10.3390/molecules26123596⟩
Article dans une revue hal-03283718v1

Efficient Terpene Production by Marine Thraustochytrids: Shedding Light on the Thermodynamic Driving Force

Natalja Kulagina , Jennifer Perrin , Sébastien Besseau , Vincent Courdavault
mBio, 2021, 12 (5), ⟨10.1128/mBio.01976-21⟩
Article dans une revue hal-03536769v1

Enhanced bioproduction of anticancer precursor vindoline by yeast cell factories

Natalja Kulagina , Grégory Guirimand , Céline Melin , Pamela Lemos‐cruz , Ines Carqueijeiro
Microbial Biotechnology, 2021, 14 (6), pp.2693-2699. ⟨10.1111/1751-7915.13898⟩
Article dans une revue hal-03339026v1

Peroxisomes: A New Hub for Metabolic Engineering in Yeast

Natalja Kulagina , Sébastien Besseau , Nicolas Papon , Vincent Courdavault
Frontiers in Bioengineering and Biotechnology, 2021, 9, ⟨10.3389/fbioe.2021.659431⟩
Article dans une revue hal-03209707v1
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Phenolamides in plants: An update on their function, regulation, and origin of their biosynthetic enzymes

Marwa Roumani , Sébastien Besseau , David Gagneul , Christophe Robin , Romain Larbat
Journal of Experimental Botany, 2021, 72 (7), pp.2334-2355. ⟨10.1093/jxb/eraa582⟩
Article dans une revue hal-03066081v1

Alternative splicing creates a pseudo-strictosidine β- d -glucosidase modulating alkaloid synthesis in Catharanthus roseus

Inês Carqueijeiro , Konstantinos Koudounas , Thomas Dugé de Bernonville , Liuda Johana Sepúlveda , Angela Mosquera
Plant Physiology, 2021, 185 (3), pp.836-856. ⟨10.1093/plphys/kiaa075⟩
Article dans une revue hal-03115782v1

Postharvest Treatment of Wood Biomass from a Large Collection of European Grape Varieties: Impact on the Selection of Polyphenol-Rich Byproducts

Kévin Billet , Marianne Unlubayir , Thibaut Munsch , Magdalena Anna Malinowska , Thomas Dugé de Bernonville
ACS Sustainable Chemistry & Engineering, 2021, 9 (9), pp.3509-3517. ⟨10.1021/acssuschemeng.0c07875⟩
Article dans une revue hal-03204455v1

Yeasts as Biopharmaceutical Production Platforms

Natalja Kulagina , Sébastien Besseau , Charlotte Godon , Gustavo Goldman , Nicolas Papon
Frontiers in Fungal Biology, 2021, 2, ⟨10.3389/ffunb.2021.733492⟩
Article dans une revue hal-03536699v1

Identifying Genes Involved in Alkaloid Biosynthesis in Vinca minor through Transcriptomics and Gene Co-Expression Analysis

Emily Amor Stander , Liuda Johana Sepúlveda , Thomas Dugé de Bernonville , Inês Carqueijeiro , Konstantinos Koudounas
Biomolecules, 2020, 10 (12), pp.1595. ⟨10.3390/biom10121595⟩
Article dans une revue hal-03062461v1

Towards the Microbial Production of Plant-Derived Anticancer Drugs

Vincent Courdavault , Sarah O’connor , Audrey Oudin , Sebastien Besseau , Nicolas Papon
Trends in Cancer, 2020, 6 (6), pp.444-448. ⟨10.1016/j.trecan.2020.02.004⟩
Article dans une revue hal-02641238v1
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Virus-Induced Gene Silencing: Hush Genes to Make Them Talk

Vincent Courdavault , Sébastien Besseau , Audrey Oudin , Nicolas Papon , Sarah Ellen O’connor
Trends in Plant Science, 2020, 25 (7), pp.714-715. ⟨10.1016/j.tplants.2020.02.013⟩
Article dans une revue hal-02866622v1
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Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle

Grégory Guirimand , Anthony Guihur , Catalina Perello , Michael Phillips , Samira Mahroug
Plants, 2020, 9 (4), pp.462. ⟨10.3390/plants9040462⟩
Article dans une revue hal-02541740v1

Setting-up a fast and reliable cytokinin biosensor based on a plant histidine kinase receptor expressed in Saccharomyces cerevisiae

Dimitri Daudu , Anna Kisiala , Carolina Werner Ribeiro , Céline Melin , Laura Perrot
Journal of Biotechnology, 2019, 289, pp.103-111. ⟨10.1016/j.jbiotec.2018.11.013⟩
Article dans une revue hal-02481316v1

Vineyard evaluation of stilbenoid‐rich grape cane extracts against downy mildew: a large‐scale study

Kevin Billet , Guillaume Delanoue , Ingrid Arnault , Sébastien Besseau , Audrey Oudin
Pest Management Science, 2019, 75 (5), pp.1252-1257. ⟨10.1002/ps.5237⟩
Article dans une revue hal-02527716v1

Genome-wide identification and biochemical characterization of the UGT88F subfamily in Malus x domestica Borkh

Carolina Elejalde-Palmett , Kevin Billet , Arnaud Lanoue , Johan-Owen de Craene , Gaelle Glevarec
Phytochemistry, 2019, 157, pp.135-144. ⟨10.1016/j.phytochem.2018.10.019⟩
Article dans une revue hal-02144180v1

Improved gene co-expression network quality through expression dataset down-sampling and network aggregation

Franziska Liesecke , Johan-Owen de Craene , Sebastien Besseau , Vincent Courdavault , Marc Clastre
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50885-8⟩
Article dans une revue hal-02483132v1

Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus

Ines Carqueijeiro , Stephanie Brown , Khoa Chung , Thu-Thuy Dang , Manish Walia
Plant Physiology, 2018, 177 (4), pp.1473-1486. ⟨10.1104/pp.18.00549⟩
Article dans une revue hal-02481447v1

Mechanical stress rapidly induces E-resveratrol and E-piceatannol biosynthesis in grape canes stored as a freshly-pruned byproduct

Kevin Billet , Benjamin Houillé , Sébastien Besseau , Céline Melin , Audrey Oudin
Food Chemistry, 2018, 240, pp.1022-1027. ⟨10.1016/j.foodchem.2017.07.105⟩
Article dans une revue hal-02407075v1

A BAHD neofunctionalization promotes tetrahydroxycinnamoyl spermine accumulation in the pollen coats of the Asteraceae family

Marianne Delporte , Guillaume Bernard , Guillaume Legrand , Björn Hielscher , Arnaud Lanoue
Journal of Experimental Botany, 2018, 69 (22), pp.5355-5371. ⟨10.1093/jxb/ery320⟩
Article dans une revue hal-02527518v1

A BAHD acyltransferase catalyzing 19‐ O ‐acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids

Ines Carqueijeiro , Thomas Duge de Bernonville , Arnaud Lanoue , Thu‐thuy Dang , Christiana Teijaro
Plant Journal, 2018, 94 (3), pp.469-484. ⟨10.1111/tpj.13868⟩
Article dans une revue hal-02481528v1

Field-Based Metabolomics of Vitis vinifera L. Stems Provides New Insights for Genotype Discrimination and Polyphenol Metabolism Structuring

Kevin Billet , Benjamin Houillé , Thomas Dugé de Bernonville , Sébastien Besseau , Audrey Oudin
Frontiers in Plant Science, 2018, 9, pp.798. ⟨10.3389/fpls.2018.00798⟩
Article dans une revue hal-02527596v1
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Ranking genome-wide correlation measurements improves microarray and RNA-seq based global and targeted co-expression networks

Franziska Liesecke , Dimitri Daudu , Rodolphe Dugé de Bernonville , Sébastien Besseau , Marc Clastre
Scientific Reports, 2018, 8 (1), pp.10885 - 10885. ⟨10.1038/s41598-018-29077-3⟩
Article dans une revue hal-01865148v1
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Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses

Thomas Dugé de Bernonville , Ines Carqueijeiro , Arnaud Lanoue , Florent Lafontaine , Paloma Sanchez-Bel
Scientific Reports, 2017, 7, ⟨10.1038/srep40453⟩
Article dans une revue hal-01602180v1

Virus-induced gene silencing in Rauwolfia species

Cyrielle Corbin , Florent Lafontaine , Liuda Johana Sepúlveda , Ines Carqueijeiro , Martine Courtois
Protoplasma, 2017, 254 (4), pp.1813-1818. ⟨10.1007/s00709-017-1079-y⟩
Article dans une revue hal-02481184v1
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CHASE-Containing Histidine Kinase Receptors in Apple Tree: From a Common Receptor Structure to Divergent Cytokinin Binding Properties and Specific Functions

Dimitri Daudu , Elsa Allion , Franziska Liesecke , Nicolas Papon , Vincent Courdavault
Frontiers in Plant Science, 2017, 8, pp.First online. ⟨10.3389/fpls.2017.01614⟩
Article dans une revue hal-01608088v1

Virus-induced gene silencing of the two squalene synthase isoforms of apple tree (Malus × domestica L.) negatively impacts phytosterol biosynthesis, plastid pigmentation and leaf growth

Sandra Navarro Gallón , Carolina Elejalde-Palmett , Dimitri Daudu , Franziska Liesecke , Frédéric Jullien
Planta, 2017, 246 (1), pp.45-60. ⟨10.1007/s00425-017-2681-0⟩
Article dans une revue hal-02152615v1

An additional Meyerozyma guilliermondii IMH3 gene confers mycophenolic acid resistance in fungal CTG clade species

Tatiana Defosse , Céline Melin , Marc Clastre , Sébastien Besseau , Arnaud Lanoue
FEMS Yeast Research, 2016, 16 (6), pp.fow078. ⟨10.1093/femsyr/fow078⟩
Article dans une revue hal-02395463v1

Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids

Claire Parage , Emilien Foureau , Franziska Kellner , Vincent Burlat , Samira Mahroug
Plant Physiology, 2016, 172 (3), pp.1563-1577. ⟨10.1104/pp.16.00801⟩
Article dans une revue hal-02395436v1

Characterization of a spermidine hydroxycinnamoyltransferase in Malus domestica highlights the evolutionary conservation of trihydroxycinnamoyl spermidines in pollen coat of core Eudicotyledons

Carolina Elejalde-Palmett , Thomas Duge de Bernonville , Gaelle Glevarec , Olivier Pichon , Nicolas Papon
Journal of Experimental Botany, 2015, 66 (22), pp.7271-7285. ⟨10.1093/jxb/erv423⟩
Article dans une revue hal-02395059v1

Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine

Thomas Dugé de Bernonville , Marc Clastre , Sebastien Besseau , Audrey Oudin , Vincent Burlat
Phytochemistry, 2015, 113, pp.9-23. ⟨10.1016/j.phytochem.2014.07.023⟩
Article dans une revue hal-03119328v1

Biosynthetic Origin of E -Resveratrol Accumulation in Grape Canes during Postharvest Storage

Benjamin Houillé , Sebastien Besseau , Vincent Courdavault , Audrey Oudin , Gaëlle Glévarec
Journal of Agricultural and Food Chemistry, 2015, 63 (5), pp.1631-1638. ⟨10.1021/jf505316a⟩
Article dans une revue hal-03119330v1

Virus-induced gene silencing in Catharanthus roseus by biolistic inoculation of tobacco rattle virus vectors

I. Carqueijeiro , E. Masini , E. Foureau , L. Sepúlveda , E. Marais
Plant Biology, 2015, 17 (6), pp.1242-1246. ⟨10.1111/plb.12380⟩
Article dans une revue hal-02395033v1
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Composition and Tissue-Specific Distribution of Stilbenoids in Grape Canes Are Affected by Downy Mildew Pressure in the Vineyard

Benjamin Houillé , Sébastien Besseau , Guillaume Delanoue , Audrey Oudin , Nicolas Papon
Journal of Agricultural and Food Chemistry, 2015, 63 (38), pp.8472-8477. ⟨10.1021/acs.jafc.5b02997⟩
Article dans une revue hal-02395067v1

Antifungal Activity of Resveratrol Derivatives against Candida Species

Benjamin Houillé , Nicolas Papon , Leslie Boudesocque-Delaye , Eric Bourdeaud , Sébastien Besseau
Journal of Natural Products, 2014, 77 (7), pp.1658-1662. ⟨10.1021/np5002576⟩
Article dans une revue hal-03333804v1

A TRP5/5-fluoroanthranilic acid counter-selection system for gene disruption in Candida guilliermondii

E. Foureau , M. Clastre , Y. Millerioux , A. J. Simkin , L. Cornet
Current Genetics, 2013, 58 (4), pp.245-254. ⟨10.1007/s00294-012-0377-3⟩
Article dans une revue hal-00818921v1

Flavonoid accumulation in Arapidopsis repressed in lignin synthesis affects auxin transport and plant growth

S. Besseau , L. Hoffmann , P. Geoffroy , C. Lapierre , B. Pollet
The Plant cell, 2007, 19, pp.148-162
Article dans une revue hal-00135740v1

Synthetic Biology in the Candida (CTG) Clade

Dalal Kasir , Marc Clastre , A. Oudin , Monzer Hamze , Sebastien Besseau
Synthetic Biology of Yeasts, 15 (19), Springer International Publishing, pp.337-375, 2022, Methods in Molecular Biology, ⟨10.1007/978-3-030-89680-5_12⟩
Chapitre d'ouvrage hal-03916787v1

Predicting Monoterpene Indole Alkaloid-Related Genes from Expression Data with Artificial Neural Networks

Thomas Duge de Bernonville , Emily Amor Stander , Géraud Dugé de Bernonville , Sebastien Besseau , Vincent Courdavault
Catharanthus roseus, 2505, Springer US, pp.131-140, 2022, Methods in Molecular Biology, ⟨10.1007/978-1-0716-2349-7_10⟩
Chapitre d'ouvrage hal-03916788v1

A Rapid and Efficient Vacuum-Based Agroinfiltration Protocol for Transient Gene Overexpression in Leaves of Catharanthus roseus

Konstantinos Koudounas , Ines Carqueijeiro , Pamela Lemos Cruz , Jennifer Perrin , A. Lanoue
Catharanthus roseus, 2505, Springer US, pp.263-279, 2022, Methods in Molecular Biology, ⟨10.1007/978-1-0716-2349-7_19⟩
Chapitre d'ouvrage hal-03916791v1

ALSV-Based Virus-Induced Gene Silencing in Apple Tree (Malus × domestica L.)

Carolina Werner Ribeiro , Thomas Dugé de Bernonville , Gaëlle Glévarec , Arnaud Lanoue , Audrey Oudin
In: Courdavault V., Besseau S. (eds) Virus-Induced Gene Silencing in Plants. Methods in Molecular Biology, vol 2172. Humana, New York, NY, pp.183-197, 2020, ⟨10.1007/978-1-0716-0751-0_14⟩
Chapitre d'ouvrage hal-03115747v1

Stilbenoid-Enriched Grape Cane Extracts for the Biocontrol of Grapevine Diseases

Kevin Billet , Magdalena Anna Malinowska , Thibaut Munsch , Marianne Unlubayir , Thomas Dugé de Bernonville
In: Mérillon JM., Ramawat K.G. (eds) Plant Defence: Biological Control. Progress in Biological Control, vol 22. Springer, Cham, pp.215-239, 2020, ⟨10.1007/978-3-030-51034-3_9⟩
Chapitre d'ouvrage hal-03115773v1

A Biolistic-Mediated Virus-Induced Gene Silencing in Apocynaceae to Map Biosynthetic Pathways of Alkaloids

Pamela Lemos Cruz , María Isabel Restrepo , Thomas Duge de Bernonville , Audrey Oudin , Thibaut Munsch
In: Courdavault V., Besseau S. (eds) Virus-Induced Gene Silencing in Plants. Methods in Molecular Biology, vol 2172. Humana, New York, NY, pp.93-110, 2020, ⟨10.1007/978-1-0716-0751-0_8⟩
Chapitre d'ouvrage hal-02877119v1

Vacuole-Targeted Proteins: Ins and Outs of Subcellular Localization Studies

Ines Carqueijeiro , Liuda Sepúlveda , Angela Mosquera , Richard Payne , Cyrielle Corbin
In: Pereira C. (eds) Plant Vacuolar Trafficking. Methods in Molecular Biology, vol 1789. Humana Press, New York, NY, 1789, pp.33-54, 2018, ⟨10.1007/978-1-4939-7856-4_4⟩
Chapitre d'ouvrage hal-02481460v1

Prequels to Synthetic Biology: From Candidate Gene Identification and Validation to Enzyme Subcellular Localization in Plant and Yeast Cells

E. Foureau , I. Carqueijeiro , T. Dugé de Bernonville , C. Melin , F. Lafontaine
Methods in Enzymology, 516, pp.167-206, 2016, ⟨10.1016/bs.mie.2016.02.013⟩
Chapitre d'ouvrage hal-02395484v1