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Sébastien Hergalant

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  • 303623
  • 413289
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Bioinformatique Cancer Biologie des systèmes Biostatistiques Multi-omiques (Epi)Génétique (Epi)Génomique Cancers cérébraux Lymphomes Maladies métaboliques Obésité Clusters de calcul Ingénierie système Plateforme de bioinformatique


Highly immunosuppressive myeloid cells correlate with early relapse after allogeneic stem cell transplantation

Anne-Béatrice Notarantonio , Allan Bertrand , Romain Piucco , Ghislain Fievet , Hervé Sartelet
Experimental Hematology & Oncology, 2024, 13 (1), pp.50. ⟨10.1186/s40164-024-00516-4⟩
Journal articles hal-04576863v1

Correction: A transgenic mice model of retinopathy of cblG‑type inherited disorder of one‑carbon metabolism highlights epigenome‑wide alterations related to cone photoreceptor cells development and retinal metabolism

Karim Matmat , Jean-Baptiste Conart , Paul-Henri Graindorge , Sandra El Kouche , Ziad Hassan
Clinical Epigenetics, 2024, 16 (1), pp.23. ⟨10.1186/s13148-024-01636-8⟩
Journal articles hal-04576854v1
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A high MCM6 proliferative index in atypical meningioma is associated with shorter progression free and overall survivals

Guillaume Gauchotte , Charles Bédel , Emilie Lardenois , Sébastien Hergalant , Laura Cuglietta
Cancers, 2023, 15 (2), pp.535. ⟨10.3390/cancers15020535⟩
Journal articles hal-03950329v1

Somatic and Germline HLA Determinants of Immune Surveillance and Escape in Myelodysplastic Syndromes

Carmelo Gurnari , Arda Durmaz , Benjamin Kroger , Hussein Awada , Jacky Chen
Blood, 2023, 142 (Supplement 1), pp.3220. ⟨10.1182/blood-2023-178890⟩
Journal articles hal-04320855v1
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Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation

Simona Pagliuca , Carmelo Gurnari , Colin Hercus , Sébastien Hergalant , Sanghee Hong
Nature Communications, 2023, 14 (1), pp.3153. ⟨10.1038/s41467-023-38113-4⟩
Journal articles hal-04162108v1

ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome

Erin Parry , Camilla Lemvigh , Stephanie Deng , Nathan Dangle , Neil Ruthen
Cancer Cell, 2023, 41 (10), pp.1803-1816.e8. ⟨10.1016/j.ccell.2023.08.013⟩
Journal articles hal-04253414v1
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Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis

Julien Broséus , Sébastien Hergalant , Julia Vogt , Eugen Tausch , Markus Kreuz
Nature Communications, 2023, 14 (1), pp.309. ⟨10.1038/s41467-022-34642-6⟩
Journal articles hal-03950368v1

Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

Erin Parry , Ignaty Leshchiner , Romain Guièze , Connor Johnson , Eugen Tausch
Nature Medicine, 2023, 29 (1), pp.158-169. ⟨10.1038/s41591-022-02113-6⟩
Journal articles hal-03950358v1

In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities

Elisa ten Hacken , Tomasz Sewastianik , Shanye Yin , Gabriela Brunsting Hoffmann , Michaela Gruber
Blood Cancer Discovery, 2023, 4 (2), pp.150-169. ⟨10.1158/2643-3230.BCD-22-0082⟩
Journal articles hal-03950340v1

Molecular landscape of immune pressure and escape in aplastic anemia

Simona Pagliuca , Carmelo Gurnari , Colin Hercus , Sébastien Hergalant , Niroshan Nadarajah
Leukemia, 2023, 37 (1), pp.202-211. ⟨10.1038/s41375-022-01723-w⟩
Journal articles hal-03950335v1
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MicroRNAs miR-16 and miR-519 control meningioma cell proliferation via overlapping transcriptomic programs shared with the RNA-binding protein HuR

Sébastien Hergalant , Jean-Matthieu Casse , Abderrahim Oussalah , Rémi Houlgatte , Deborah Helle
Frontiers in Oncology, 2023, 13, pp.1158773. ⟨10.3389/fonc.2023.1158773⟩
Journal articles hal-04176105v1
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Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12

Abderrahim Oussalah , Youssef Siblini , Sébastien Hergalant , Céline Chéry , Pierre Rouyer
Clinical Epigenetics, 2022, 14 (1), pp.52. ⟨10.1186/s13148-022-01271-1⟩
Journal articles hal-03664165v1
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ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressing Methionine Dependency

Maëlle Quéré , Jean-Marc Alberto , Franck Broly , Sébastien Hergalant , Christo Christov
Nutrients, 2022, 14 (9), pp.1887. ⟨10.3390/nu14091887⟩
Journal articles hal-03664166v1
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Correlation between DNA Methylation and cell proliferation identifies new candidate predictive markers in meningioma

Sébastien Hergalant , Chloé Saurel , Marion Divoux , Fabien Rech , Celso Pouget
Cancers, 2022, 14 (24), pp.6227. ⟨10.3390/cancers14246227⟩
Journal articles hal-03939191v1

ZNF683 (Hobit) Marks a CD8+ T Cell Population Associated with Anti-Tumor Immunity Following Anti-PD-1 Therapy for Richter Syndrome

Camilla Lemvigh , Erin Michelle Parry , Stephanie Deng , Nathan Dangle , Neil Ruthen
Blood, 2022, 140 (Supplement 1), pp.1807-1808. ⟨10.1182/blood-2022-162550⟩
Journal articles hal-03950370v1
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Long-Term Overconsumption of Fat and Sugar Causes a Partially Reversible Pre-inflammatory Bowel Disease State

Djésia Arnone , Marie Vallier , Sébastien Hergalant , Caroline Chabot , Ndeye Coumba Ndiaye
Frontiers in Nutrition, 2021, 8, pp.758518. ⟨10.3389/fnut.2021.758518⟩
Journal articles hal-03430881v1

Low-frequency coding variants associated with body-mass-index impact the success of bariatric surgery

Darlène Antoine , Rosa-Maria Guéant-Rodriguez , Jean-Claude Chèvre , Sébastien Hergalant , Tanmay Sharma
Journal of Clinical Endocrinology and Metabolism, 2021, pp.dgab774. ⟨10.1210/clinem/dgab774⟩
Journal articles hal-03411898v1

Facteurs pronostiques clinico-biologiques et génomiques de la survie dans le syndrome de Richter

C. Moulin , F. Guillemin , T. Remen , F. Bouclet , H. Augé
Epidemiology and Public Health = Revue d'Epidémiologie et de Santé Publique, 2021, 69 (1), pp.52. ⟨10.1016/j.respe.2020.11.010⟩
Journal articles hal-03238804v1

Vitamin B 12 Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions

Pauline Mosca , Aurélie Robert , Jean‐marc Alberto , Marie Meyer , Urbi Kundu
Molecular Nutrition and Food Research, 2021, 65 (17), pp.2100206. ⟨10.1002/mnfr.202100206⟩
Journal articles hal-03300551v1
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Clinical, biological, and molecular genetic features of Richter syndrome and prognostic significance: a study of the French Innovative Leukemia Organization

Charline Moulin , Francis Guillemin , Thomas Remen , Florian Bouclet , Sébastien Hergalant
American Journal of Hematology, 2021, 96 (9), pp.E311-E314. ⟨10.1002/ajh.26239⟩
Journal articles hal-03238759v1

Fetal Programming by Methyl Donor Deficiency Produces Pathological Remodeling of the Ascending Aorta

Brittany Balint , Sébastien Hergalant , Jean-Michel Camadro , Sébastien Blaise , Laetitia Vanalderwiert
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41 (6), pp.1928-1941. ⟨10.1161/atvbaha.120.315587⟩
Journal articles hal-03238712v1
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Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

Youssef Siblini , Céline Chéry , Pierre Rouyer , Jérémie Raso , Amélia Julien
Clinical Epigenetics, 2021, 13 (1), pp.212. ⟨10.1186/s13148-021-01199-y⟩
Journal articles hal-03465924v1

Clinico-Biological, Molecular and Prognostic Features of Patients with Diffuse Large B-Cell Lymphoma-Variant of Richter Syndrome: A Multicenter Retrospective Study of the French Innovative Leukemia Organization

Charline Moulin , Francis Guillemin , Thomas Rémen , Florian Bouclet , Hélène Augé
Blood, 2020, 136 (Suppl 1), pp.3-5. ⟨10.1182/blood-2020-137101⟩
Journal articles hal-03054135v1
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First identification of dopamine receptors in pikeperch, Sander lucioperca, during the pre-ovulatory period

Jennifer Roche , Sébastien Hergalant , Amandine Depp , Imen Ben Ammar , Anne-Gaelle Lafont
Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2020, 36, pp.100747. ⟨10.1016/j.cbd.2020.100747⟩
Journal articles hal-02975537v1
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Microenvironment Remodeling and Subsequent Clinical Implications in Diffuse Large B-Cell Histologic Variant of Richter Syndrome

Hélène Augé , Anne-Béatrice Notarantonio , Romain Morizot , Anne Quinquenel , Luc-Matthieu Fornecker
Frontiers in Immunology, 2020, 11, pp.594841. ⟨10.3389/fimmu.2020.594841⟩
Journal articles hal-03087137v1
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Mobilized Multipotent Hematopoietic Progenitors Stabilize and Expand Regulatory T Cells to Protect Against Autoimmune Encephalomyelitis

Sarantis Korniotis , Maud d'Aveni , Sébastien Hergalant , Hélène Letscher , Emmanuel Tejerina
Frontiers in Immunology, 2020, 11, pp.607175. ⟨10.3389/fimmu.2020.607175⟩
Journal articles hal-03087148v1

Large-Scale Proteomics Identifies Distinct Signatures for Richter Syndrome and De Novo Diffuse Large B-Cell Lymphoma: A French Study from the Filo Group

Romain Morizot , Sébastien Hergalant , Romain Piucco , Florian Bouclet , Anne Quinquenel
Blood, 2020, 136 (Supplement 1), pp.29-30. ⟨10.1182/blood-2020-137061⟩
Journal articles hal-03054165v1
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Ki‐67 and MCM6 labelling indices are correlated with overall survival in anaplastic oligodendroglioma, IDH1 ‐mutant and 1p/19q‐codeleted: a multicenter study from the French POLA network

Celso Pouget , Sébastien Hergalant , Emilie Lardenois , Stéphanie Lacomme , Rémi Houlgatte
Brain Pathology, 2020, 30 (3), pp.465-478. ⟨10.1111/bpa.12788⟩
Journal articles hal-02299833v1
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Analysis of fibroblasts from patients with cblC and cblG genetic defects of cobalamin metabolism reveals global dysregulation of alternative splicing

Charif Rashka , Sébastien Hergalant , Natacha Dreumont , Abderrahim Oussalah , Jean-Michel Camadro
Human Molecular Genetics, 2020, 29 (12), pp.1969-1985. ⟨10.1093/hmg/ddaa027⟩
Journal articles hal-03100129v1

Wnt Signaling Pathways Are Dysregulated in Rat Female Cerebellum Following Early Methyl Donor Deficiency

Jérèmy Willekens , Sébastien Hergalant , Grégory Pourié , Fabian Marin , Jean-Marc Alberto
Molecular Neurobiology, 2019, 56 (2), pp.892-906. ⟨10.1007/s12035-018-1128-3⟩
Journal articles hal-01804097v1
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Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency

Racha Zgheib , Shyue-Fang Battaglia-Hsu , Sébastien Hergalant , Maelle Quéré , Jean-Marc Alberto
Cell Death and Disease, 2019, 10 (8), pp.596. ⟨10.1038/s41419-019-1836-2⟩
Journal articles hal-02265213v1
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Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR

Shyue-Fang Battaglia-Hsu , Rose Ghemrawi , David Coelho , Natacha Dreumont , Pauline Mosca
Nucleic Acids Research, 2018, 46 (15), pp.7844-7857. ⟨10.1093/nar/gky634⟩
Journal articles hal-01844820v1

Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia

Guillaume Gauchotte , Sébastien Hergalant , Charlène Vigouroux , Matthieu Casse , Rémi Houlgatte
The Journal of pathology and bacteriology, 2017, 242 (4), pp.421 - 434. ⟨10.1002/path.4916⟩
Journal articles hal-01718786v1
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Relapsed diffuse large B-cell lymphoma present different genomic profiles between early and late relapses

Julien Broséus , Gaili Chen , Sébastien Hergalant , Gérard Ramstein , Nicolas Mounier
Oncotarget, 2016, 7 (51), pp.83987-84002. ⟨10.18632/oncotarget.9793⟩
Journal articles hal-02314515v1

Identification of master genes involved in liver key functions through transcriptomics and epigenomics of methyl donor deficiency in rat: Relevance to nonalcoholic liver disease

Gaili Chen , Julien Broséus , Sébastien Hergalant , Audrey Donnart , Catherine Chevalier
Molecular Nutrition and Food Research, 2015, 59 (2), pp.293 - 302. ⟨10.1002/mnfr.201400483⟩
Journal articles hal-01755906v1
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A new data mining approach for the detection of bacterial promoters combining stochastic and combinatorial methods

Catherine Eng , Charu Asthana , Bertrand Aigle , Sébastien Hergalant , Jean-Francois Mari
Journal of Computational Biology, 2009, 16 (9), pp.1211-1225. ⟨10.1089/cmb.2008.0122⟩
Journal articles inria-00419969v1
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Multi-omics characterization of Richter syndrome unlocks classifiers and predictors of outcome into broader and heterogeneous lymphoma datasets

Sébastien Hergalant , Romain Piucco , Ghislain Fiévet , Emil Chteinberg , Stephan Stilgenbauer
JOBIM2023, Jun 2023, Plouzané (Brest), France
Conference papers hal-04147573v1

Etude du méthylome et du transcriptome dans le Syndrome de Richter

Sébastien Hergalant , Julien Broséus
6e journées du FILO, Oct 2020, Nancy, France
Conference papers hal-03177006v1

Description d'une nouvelle signature immunitaire dans le contexte de la rechute après allogreffe de Cellules Souches Hématopoïétiques

Anne-Béatrice Notarantonio , Romain Piucco , Sébastien Hergalant , Laura Boulangé , Jordan Brouard
6ème Journée de la French Innovative Leukemia Organization, Oct 2020, Nancy, France
Conference papers hal-02976925v1

Caractérisation du profil protéomique du Syndrome de Richter

Romain Piucco , Romain Morizot , Luc-Matthieu Fornecker , Pierre Feugier , Sébastien Hergalant
6e journées de la French Innovative Leukemia Organization, Oct 2020, Nancy, France
Conference papers hal-03176937v1

Ki-67 and MCM6 labelling index are correlated with overall survival in anaplastic oligodendroglioma, IDH1-mutant and 1p/19q codeleted: a multicenter study from the French POLA Network

Celso Pouget , Sébastien Hergalant , Emilie Lardenois , Shyue-Fang Battaglia-Hsu , Rémi Houlgatte
31 st European Congress of Pathology, Sep 2019, Nice, France. pp.1-436, ⟨10.1007/s00428-019-02631-8⟩
Conference papers hal-03012220v1
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Data Mining Using Hidden Markov Models (HMM2) to Detect Heterogeneities into Bacteria Genomes

Catherine Eng , Annabelle Thibessard , Sébastien Hergalant , Jean-François Mari , Pierre Leblond
Journées Ouvertes Biologie, Informatique et Mathématiques - JOBIM 2005, JOBIM, Jul 2005, Lyon/France, France
Conference papers inria-00000142v1
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Fouille de données du génome à l'aide de modèles de Markov cachés

Sébastien Hergalant , Bertrand Aigle , Pierre Leblond , Jean-François Mari
Extraction et Gestion de Connaissances - EGC 2005, Jan 2005, Paris/France, France. pp.141 -- 148
Conference papers inria-00001213v1
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Classification non supervisée par HMM de sites de fixation de facteurs de transcription chez les bactéries

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Jean-François Mari , Pierre Leblond
5èmes Journées Ouvertes : Biologie, Informatique et Mathématiques - JOBIM'04, 2004, Montréal, Canada, 1 p
Conference papers inria-00107788v1

HMM, an Efficient Way to Detect Transcriptional Promoters in Bacterial Genomes?

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Jean-François Mari , Pierre Leblond
European Conference on Computational Biology - ECCB'2003, Sep 2003, Paris, France, pp.417--419
Conference papers inria-00099570v1

Intragenomic reiterations detection using hidden Markov models

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Pierre Leblond , Jean-François Mari
10th International Conference on Intelligent Systems for Molecular Biology - ISMB 2002, Aug 2002, Edmonton, Canada, 1 p
Conference papers inria-00100914v1

Fouille de données à l'aide de HMM : Application à la détection de réitérations intragénomiques

Sébastien Hergalant , Bertrand Aigle , Bernard Decaris , Pierre Leblond , Jean-François Mari
Journées Ouvertes Biologie Informatique Mathématiques - JOBIM'02, François Coste - Elisabeth Lebret, 2002, Saint Malo, France, pp.269-273
Conference papers inria-00100752v1
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Fouille de données du génome à l'aide de modèles de Markov cachés

Sébastien Hergalant , Bertrand Aigle , Pierre Leblond , Jean-François Mari
Extraction et gestion des connaissances. EGC 2005, Cépaduès, 2005, Revue des Nouvelles Technologies de l'Information, 2-85428-677-4 2-85428-682-0 (vol. 1) 2-85428-683-9 (vol. 2)
Book sections hal-02832934v1