Séverine Derbré
Présentation
Séverine Derbré is a scientist in the field of natural products (NPs) and a trained pharmacist. After graduating from The School of Pharmacy in Angers in 2002, she obtained a PhD thesis in chemistry of NPs under the supervision of Pr. Erwan Poupon and Pr. Reynald Hocquemiller in 2006 at the Paris 11 University. Subsequently she worked as a post-doctoral fellow at the French Alternative Energies and Atomic Energy Commission (Commissariat à l'énergie atomique et aux énergies alternatives, CEA Saclay, France) together with Yves Ambroise in the laboratory directed by Charles Mioskowski and Bernard Rousseau. In 2007, she was recruited as an assistant professor of pharmacognosy by the University of Angers, School of Pharmacy, and joined the SONAS laboratory, directed by Pr Pascal Richomme (2007-2022) and Pr David Guilet (2023-). Her fields of interest relate to NPs chemistry and biological activities with special focus on the extraction, purification and structural determination of bio-active NPs from tropical endemic Clusiaceous and Calophyllaceous species. Another main focus of her research is the semisynthesis on crude vegetal extracts from more common and available plants. She also developed an automated anti-AGE screening assay facilitating a rapid evaluation of NPs and extracts for potential cosmetic and therapeutic applications (prevention of cardiovascular events and graft rejections).
She is also very involved in the development of new methods for the rapid identification of active molecules in complex matrices based on mass spectrometry (LDI-HRMS; UPLC-HRMS) and 13C NMR. In the field, with her team, she recently developed a free available software, namely MixONat (https://sourceforge.net/projects/mixonat/), to decipher complex mixtures based on 13C-NMR spectra. If you need help to install the software and/or require ad hoc databases, feel free to contact her.
Publications
Publications
The phytochemical diversity of wild hops from northern France for potential brewing applicationInternational Congress on Natural Products Research (ICNPR2024), PSE; GA; ASP; AFERP; The Japanese Society of Pharmacognosy; The Korean Society of Pharmacognosy; Societa Italiana Di Fitochimica, Jul 2024, Krakow, Poland. pp.103707, ⟨10.1016/j.phytol.2025.103707⟩ |
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Guttiferones-targeted dereplication integrating LC-HRMS/MS and 13C-NMR data: A comparative metabolomic study of Symphonia globulifera latexInternational Congress on Natural Products Research (ICNPR2024), PSE; GA; ASP; AFERP; The Japanese Society of Pharmacognosy; The Korean Society of Pharmacognosy; Societa Italiana Di Fitochimica, Jul 2024, Krakow, Poland. pp.103407, ⟨10.1016/j.phytol.2025.103407⟩ |
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Matrix free laser desorption ion mobility mass spectrometry in chemometrics: A new approach to the rapid identification of activity markers in complex mixtures of natural productsInternational Congress on Natural Products Research (ICNPR2024), PSE; GA; ASP; AFERP; The Japanese Society of Pharmacognosy; The Korean Society of Pharmacognosy; Societa Italiana Di Fitochimica, Jul 2024, Krakow, Poland. pp.103800, ⟨10.1016/j.phytol.2025.103800⟩ |
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Pharmacognosy faces new challenges: proposals to combine chemometrics and annotations based on mass spectrometry and NMR for more accurate and faster identification of bioactive natural products in complex matricesInternational Congress on Natural Products Research (ICNPR2024), Jul 2024, Krakow, Poland. pp.103076, ⟨10.1016/j.phytol.2025.103076⟩ |
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Place of 13C NMR in the annotation of natural products of interest. Examples of strategies currently being developed3th France-Brazil meeting on Natural products, Jun 2024, La Rochelle, France |
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Métabolites spécialisés de Cannabis sativa : diversité chimique et bioactivitéSéminaire thématique « Cannabis médical : enjeux réglementaires et scientifique », Chaire Innovations Agrosanté, Nov 2024, Angers, France |
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Combining chemometrics and dereplication based on NMR and/or mass spectrometry: a way for natural product chemists to work more efficiently for humanity in a changing world?4th France-Brazil meeting on Natural products, Nov 2024, Aracaju (Sergipe), Brazil |
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Finding actives in a haystack faster and more accurately? Proposed workflows combining chemometrics and dereplication based on both MS and 13C NMR6e Symposium International de l’AFERP, Association Francophone des enseignants Chercheurs en Pharmacognosie (AFERP), Jul 2023, Orsay, France |
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Looking for actives in a haystack: PAMS merges HRMS²-based molecular networking, chemometrics and 13C NMR-based dereplication approaches10+3 ans de la plateforme CORSAIRE, Plateforme CORSAIRE (Biogenouest), Jan 2023, Roscoff, France |
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MixONat: A 13C NMR-based dereplication of natural products mixtures as a complementary tool to MS analysisAFERP Virtual symposium, Association Francophone des enseignants Chercheurs en Pharmacognosie (AFERP), Jul 2021, Webinaire, France |
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Pharmacognosie : De l'usage ancestral des plantes médicinales aux valorisations actuelles des métabolites secondairesSéminaire « Innovation du végétal en sante : Les métabolites secondaires des plantes et leur valorisation pour la santé », Chaire Innovations Agrosanté, Nov 2021, Angers, France |
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13C-NMR dereplication of complex mixtures using a custom softwareJournées de l’école doctorale EGAAL, Jul 2019, Rennes, France |
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Anti-ageing NPs: screening and identification in mixtures using 13C-NMR.4th International Symposium: Analytical Chemistry Research & Development and Quality Control of Health Products., Oct 2019, Bordeaux, France |
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MixONat: Assistance aux analyses déréplicatives par RMN-13CJournée Scientifique Biogenouest « Du phénome au métabolome », Oct 2019, Angers, France |
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13C-NMR dereplication of compex mixtures: building a custom search algorithm3rd AFERP & STOLON International Symposium, Jul 2018, Rennes, France |
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Du criblage anti-AGEs d’extraits végétaux à des pharmacophores et cibles thérapeutiques potentiels pour prévenir les rejets de greffe d’organesUniversité de Montréal, Apr 2017, Montréal, Canada |
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NMR dereplication of Asian Clusiaceae and Calophyllaceae as promising sources of immunosuppressive PPAPsInternational Malaysian-French Scientific Conference, Dec 2017, Kuala-Lumpur, Malaysia |
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Usages thérapeutiques des plantes de la famille Cupressaceae4ème Journée des Pollinariums sentinelles de France, Mar 2016, Vannes, France |
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Usages thérapeutiques des plantes du genre Plantago3e Journée des Pollinariums Sentinelles de France, Mar 2015, Angers, France |
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Du criblage anti-AGEs d'extraits végétaux à un actif cosmétique breveté et commercialiséJournée d’échanges prospectifs entre acteurs académiques et socio-économiques d’Objectif végétal, Dec 2015, Angers, France |
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Lepidotols and lepidotins: new phenylcoumarins from Mesua lepidota as promising inhibitors of endothelial immune responses and dysfunction63rd international congress and annual meeting of the society for medicinal plant and natural product research (GA), Aug 2015, Budapest, Hungary. pp.16, ⟨10.1055/s-0035-1565368⟩ |
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From dereplication and anti-inflammatory screening of Clusiaceae and Calophyllaceae species to novel immunomodulatory coumarins from Mesua lepidota22e GP2A meeting of the "Groupement des Pharmacochimistes de l'Arc Atlantique, 2014, Nantes, France |
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Anti-AGE natural products : screening and valorisation22e GP2A meeting of the "Groupement des Pharmacochimistes de l'Arc Atlantique, 2014, Nantes, France |
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Effets anti-inflammatoire et immunomodulateur de composés polyphénoliques isolés de Clusiaceae et de CalophyllaceaeJournées de l’école doctorale VENAM, 2014, Angers, France |
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Plantes et santé : les plantes, de petites usines chimiques au service de notre santé ?5 conférences : Cycle végétal, 2014, Angers, France |
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Valorisation des produits d’origine végétale anti-AGEs"titre manquant", 2014, Constantine, Algérie |
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Anti-inflammatory and immunomodulatory properties of polyphenolic compounds from Clusiaceae/Calophyllaceae: A focus on coumarins62nd International Congress and Annual Meeting of the Society of Medicinal Plant and Natural Product Research, 2014, Guimarães, Portugal. pp.P1L3, ⟨10.1055/s-0034-1394661⟩ |
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Chemical composition and antiglycoxidant activities of French organic propolis extractsTrends in natural products research 2013 : A young scientists meeting of PSE and ÖPhG, 2013, Obergurgl, Austria |
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Mise au point d’un criblage automatisé d’inhibiteurs de la formation des AGEs applicable aux extraits végétaux3e Journée Inter-régionale de Chimie Moléculaire et Thérapeutique, 2012, Le Mans, France |
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Plantes et santé : Médicaments et compléments alimentaires à base de plantes : quelles efficacité, qualité et sécurité ?XIXe symposium d’hépatogastroentérologie, 2011, Angers, France |
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Formation d’AGEs sur support solide et caractérisation par fluorescenceJournées de l’école doctorale VENAM, 2011, Angers, France |
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The PROVASC project: Identification of natural products able to prevent endothelial dysfunctionCommunication orale à la Faculté de Pharmacie de Séville, 2011, Séville, Espagne |
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Recherche d’inhibiteurs des réactions de glycation : du test à la moléculeSCF-BPL 2011 - Les Journées scientifiques de la Société Chimique de France, Section Bretagne - Pays de la Loire, 2011, Noirmoutier, France |
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PROVASC : Vers l’identification de produits naturels limitant la dysfonction endothéliale1ère Journée Inter-régionale de Chimie Moléculaire et Thérapeutique, 2010, Rennes, France |
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Desorption/ionization on self-assembled monolayer surfaces (DIAMS): a new matrix-free laser desorption/ionization promising for the analysis of vegetal extracts7th Joint Meeting of GA, AFERP, ASP, PSE & SIF, 2008, Athènes, Greece. pp.093, ⟨10.1055/s-0028-1084549⟩ |
Identification of glycogen phosphorylase as molecular target for antidiabetic action of Nauclea latifolia Smith fruits.67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Sep 2019, Innsbruck, Austria. Planta Medica, 85 (18), pp.1389, 2019, ⟨10.1055/s-0039-3399633⟩ |
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Secondary metabolites from marine sources as inhibitors of advanced glycation end products (AGEs) and collagenase67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP, Sep 2019, Innsbruck, France. Planta medica, 85 (18), pp.1547, 2019, ⟨10.1055/s-0039-3400086⟩ |
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13C-NMR dereplication of medicinal plant extracts using a home-made software.67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Sep 2019, Innsbruck, Austria. Planta Medica, 85 (18), pp.1458, 2019, ⟨10.1055/s-0039-3399821⟩ |
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Secondary metabolites from lichens as promising inhibitors of the formation of pentosidine like advanced glycosylation end products3rd AFERP & STOLON International Symposium, Jul 2018, Rennes, France. |
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13C-NMR dereplication of complex mixtures using a custom algorithm: application to a Garcinia mangostana fruit peel extract3rd AFERP & STOLON International Symposium, Jul 2018, Rennes, France. |
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Modulation of the expression of MHC molecules by PPAPs from Garcinia bancana5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France. |
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Chemical engineering on St John’s wort extracts to prevent endothelial dysfunction: a bioconversion approach5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France. |
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13C-NMR dereplication of complex mixtures: predicted vs experimental chemical shifts databases5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France. |
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Total synthesis and determination of the absolute configuration of Hyperbiphenyl A and B, isolated from the roots of Hypericum perforatum5th AFERP International Conference "Pharmacognosy from here and there", Jul 2017, Angers, France. |
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Chemically engineered extracts of St John’s wort as sources of polyprenylated acylphloroglucinols to prevent endothelial dysfunction9th Joint Natural Products Conference, 2016, Copenhague, Denmark. , Planta Medica, 82 (S01), pp.S1, 2016 |
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Poplar-type propolis components as trapping agents to prevent the formation of Advanced Glycation End-products (AGEs)9th Joint Natural Product Conference, Jul 2016, Copenhague, Denmark. Thieme, Planta medica, 82 (01), pp.S01-S381, 2016, ⟨10.1055/s-0036-1596291⟩ |
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Lepidotols and Lepidotins: New Phenylcoumarins from Malaysian Mesua Species63rd international congress and annual meeting of the society for medicinal plant and natural product research (GA), Aug 2015, Budapest, Hungary. Planta Medica, 81, pp.PM124, 2015, ⟨10.1055/s-0035-1565501⟩ |
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Chemically engineered extracts of Hypericum perforatum (St John’s wort) as sources of bioactive compounds to prevent endothelial dysfunction2ème Symposium International AFERP-STOLON "Biodiversité et substances naturelles", Jul 2015, Lyon, France |
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Variability of Calophyllum tetrapterum phytoconstituents in relation with their anti-inflammatory properties2ème Symposium International AFERP-STOLON "Biodiversité et sustances naturelles", Jul 2015, Lyon, France |
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Different phytochemical compositions of propolis samples collected in Ivory Coast, Africa2nd AFERP-STOLON International Symposium, Jul 2015, Lyon, France. |
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Phloroglucinol : a simple core for new anti-AGEs derivatives - synthesis, anti-AGEs activity and RSA22e GP2A meeting of the "Groupement des Pharmacochimistes de l'Arc Atlantique", 2014, Nantes, France. 2014 |
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Anti-AGE algerian vegetal extracts. Phytochemical study of Bupleurum lancifolium (Apiaceae)5th International Chemistry Conference, 2014, Abha, Saudi Arabia. 2014 |
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Anti-AGE bioguided fractionation and dereplication study of Calophyllum wallichianum stem bark10e reuniόn internacional de investigaciόn en productos naturales, 2014, Merida, Mexico. 2014 |
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Screening of anti-AGE properties and dereplication of extracts from algerian medicinal plants22e GP2A meeting of the "Groupement des Pharmacochimistes de l'Arc Atlantique", 2014, Nantes, France. 2014 |
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New anti-AGE compounds from Mammea neurophylla (Calophyllaceae)International Conference on Natural Products Utilization: From Plants to Pharmacy Shelf, 2013, Bansko, Bulgaria. 2013 |
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Selection of Algerian medicinal plants according to a screening of their anti-AGEs propertiesAFERP & STOLON International Symposium, 2013, Bruxelles, Belgium. 2013 |
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Chemical engineering on Mammea neurophylla extract to improve anti-AGEs potentialAFERP & STOLON International Symposium, 2013, Bruxelles, Belgium. 2013 |
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Selection of Clusiaceae and Calophyllaceae extracts based on dereplication and anti-inflammatory propertiesAFERP & STOLON International Symposium, 2013, Brussels, Belgium. 2013 |
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Criblage d’extraits de plantes malaisiennes : étude phytochimique et évaluation des propriétés anti-inflammatoiresLes docteurs : acteurs de la fonction publique, 2013, Angers, France. 2013 |
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Anti-AGEs phloroglucinol derivatives. Synthesis, anti-AGEs and vaso-activity evaluationRICT 2012 - Interfacing Chemical Biology and Drug Discovery, 2012, Poitiers, France. 2012 |
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Identification of coumarins in DCM bark, leaf and fruit extracts from Mammea neurophylla (Calophyllaceae) by LC-PDA-MSnInternational Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, 2012, New-York, United States. Planta Medica, 78 (11), p. 1260, 2012, ⟨10.1055/s-0032-1321213⟩ |
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Anti-ages activity screening of molecules isolated from Tanzanian clusiaceous speciesInternational Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, 2012, New-York, États-Unis. Planta Medica, 78 (11), pp.1227 - 1228, 2012, ⟨10.1055/s-0032-1321060⟩ |
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Benzophenone derivatives : From natural source to synthetic one. Synthesis and anti-AGEs activityThe XXth meeting of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. 2011 |
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Isolement par chromatographie de partage centrifuge (CPC) des métabolites secondaires de l’extrait acétate d’éthyle des fleurs de Senecio giganteus Desf. (Asteraceae)18e Journée Jeunes chercheurs de la Société de Chimie Thérapeutique, 2011, Paris, France. 2011 |
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Formation of AGEs in heterogeneous phaseThe XXth meeting of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. , 2011 |
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Isolation and purification of anti-AGEs products from methanolic bark extract of Mammea neurophylla using bioguided fractionationThe XXth meeting of the Groupement des Pharmacochimistes de l’Arc Atlantique (GP2A), 2011, Cork, Ireland. 2011 |
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Identification de métabolites secondaires anti-oxydants et anti-AGEs à partir d’un extrait DCM d’écorce de Mammea neurophylla (Schltr.) Kosterm par criblage bioguidéJournées de l’école doctorale VENAM - Végétal, Environnement, Nutrition, Agroalimentaire, Mer, 2011, Angers, France. 2011 |
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Criblage bioguidé de métabolites secondaires anti-AGEs des feuilles de Calophyllum flavo-ramulum (Clusiaceae)4e journées internationales de l’AFERP - Association francophone pour l'enseignement et le recherche en pharmacognosie, 2010, Besançon, France. 2010 |
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Development of a 96-wells plate screening in supporting phase19e rencontres européennes du groupement des pharmacochimistes de l’arc atlantique, 2010, Mont Saint Aignan, France. 2010 |
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Photophysical behavior of 4-methylumbelliferone’s SAM’s on different substrateElecMol'10 - 5th International Conference on Molecular Electronics, 2010, Grenoble, France. 2010 |
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Mise au point d‟une nouvelle méthode de criblage sur support solide"titre manquant", 2010, Paris, France. 2010 |
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Automatisation d’un test de criblage en plaque 96 puits pour l’identification d’inhibiteurs des AGEs : application au criblage d’une petite chimiothèque de produits naturels17e journée Jeunes chercheurs de la Société de Chimie Thérapeutique, 2010, Paris, France. 2010 |
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Synthesis and anti-AGEs testing of phloroglucinol derivatives19e rencontres européennes du groupement des pharmacochimistes de l’arc atlantique, 2010, Mont Saint Aignan, France. 2010 |
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New self-assembled monolayers for DIAMS mass spectrometry"titre manquant", 2009, Dublin, Ireland. 2009 |
Use of 3-phenyl-prop-2-enoic acid esters from papaya as biodegradable anti-scaling agents to inhibit formation of limestone depositsFrance, Patent n° : FR 3072088 A1 20190412. 2019 |
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Anti-glycation agent comprising a Garcinia kola extract or fractionFrance, Patent n° : Non spécifié. 2014 |