Sophie PAYOT-LACROIX
73
Documents
Researcher identifiers
sophie-payot-lacroix
- ResearcherId : https://publons.com/researcher/1555432/sophie-payot/
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0000-0001-7266-3071
- IdRef : 078886562
Presentation
**Biography:**
I obtained my PhD in cellular, molecular and structural biology at Nancy University in 1999. My PhD work, carried under the supervision of H. Petitdemange, focused on cellobiose catabolism and sporulation of the anaerobic bacterium *Clostridium cellulolyticum*. After having insight on the green waste recycling potential of bacteria, I spent one year in England (team of D. O’Connor, University of Southampton) to explore stress response and virulence of *Salmonella* Typhimurium. In September 2000, I was appointed as permanent INRA research scientist in the UR086 INRA (Tours-Nouzilly) where I joined the antibioresistance team of E. Chaslus-Dancla to work on the mechanisms of antibiotic resistance in *Campylobacter*. In 2006, I moved to Nancy to work on gene transfers mediated by Integrative Conjugative Elements (ICEs) in streptococci in the UMR1128 UL/INRA DynAMic. In January 2017, I was promoted INRA Senior Researcher (Directeur de Recherches INRA).
**Research topic:**
Since more than 20 years now, my research work focuses on the fascinating power of bacteria to adapt to their environment: from flexibility of the catabolic pathways to sporulation for a cellulolytic anaerobic bacterium, host adaptation of the zoonotic pathogen *Salmonella* Typhimurium, antibiotic resistance of the zoonotic pathogen Campylobacter and adaptation of streptococci through horizontal gene transfers mediated by mobile genetic elements. Keeping in mind the global bacterial physiology, I am interested in characterizing these mechanisms of adaptation at the molecular level. My current research projects aim at determining biotic and abiotic factors (cell surface composition, stress, sub-lethal antibiotic concentrations, biofilm) that promote transfer by conjugation of Mobile Genetic Elements (in particular Integrative and Conjugative Elements (ICEs) and Integrative Mobilizable Elements (IMEs)) of streptococci and elucidating the underlying molecular mechanisms of regulation. I am also interested in the prevalence and diversity of ICEs and IMEs in the genomes of Firmicutes and their role in antibiotic resistance dissemination.
**Responsabilities:**
Member of the Scientific Committee of the French National Observatory for Epidemiology of Bacterial Resistance to Antimicrobials ([www.onerba.org](http://www.onerba.org)) (2003-2004) and of INRA Microbiology Department (2006-), team leader (2009-2015), Quality Manager (of INRA Microbiology Department 2008-2012 and of UMR1128 since 2007) and UMR1128 Deputy Director (2018-). Coordination of 7 regional projects, an INRA-Anses national project and a national project funded by the French National Research Agency (MATICE ANR-15-CE21-0007).
**Contact:**
E-mail: [sophie.payot-lacroix@inrae.fr](mailto:sophie.payot-lacroix@inra.fr)
Tel : +33 3 72 74 51 48
Publications
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Resistance to macrolides-lincosamides and tetracyclines of Streptococcus suis strains isolated from swine in France16e congrès national de la Société Française de Microbiologie « MICROBES », Sep 2021, Nantes, France
Conference poster
hal-03495833v1
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The ICE/IME Finder approach and its application to ICE/IME annotation in StreptococcusConference poster hal-02974525v1 |
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A glimpse into an unexplored world: very high diversity of integrative and mobilizable elements in Streptococci8th ASM conference on Streptococcal Genetics, Jul 2016, Washington, United States
Conference poster
hal-02974398v1
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Diversity of Integrative and Conjugative Elements of Streptococcus salivarius and their intra- and interspecies transfers8th ASM conference on Streptococcal Genetics, Jul 2016, Washington, United States
Conference poster
hal-02974520v1
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Better Understand the Campylobacter Conundrum : Parallel Between Campylobacter Jejuni Genome, Sequence Study and Physiology.Michael C. Berger. New Developments in Food Microbiology Research, Nova Publishers, pp.1-90, 2007
Book sections
hal-00453220v1
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Les multiples façons de faire de la résistance aux antibiotiquesAntibiothérapie bovine. Acquis et Consensus, Pfizer Santé Animale, 2002
Book sections
hal-01637763v1
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La folle course aux armements des bactéries contre les antibiotiques2018
Other publications
hal-01889239v1
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Habilitation à diriger des recherches2005, 137 p
Other publications
hal-01637777v1
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Etude des conditions physiologiques influançant [i.e. influençant] la croissance, le catabolisme du cellobiose et la sporulation de Clostridium Cellulolytycum ATCC 35319Biochimie, Biologie Moléculaire. Université Henri Poincaré - Nancy 1, 1999. Français. ⟨NNT : 1999NAN10266⟩
Theses
tel-01748147v1
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