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Sophie Novault



Sophie Novault has joined the Institut Pasteur in January 2014 as a head of the flow cytometry platform, to initiate change, reorganize the team and manage the resources. Previously, she worked for ten years for a worldwide flow company, Becton Dickinson Biosciences (BD), first as an Application Specialist and then as the director of Training Center France. As a member of the European BD working group she participated to evaluation of new technologies. During the years spent at BD Sophie Novault acquired a high technical expertise in flow cytometry and cell sorting, and has developed a real sense of service activity and means to meet user’s satisfaction. Since the creation of the Center for Translational Science of the Institut Pasteur (CRT), and subsequently of the CB UTechS Sophie Novault has been responsible of the Cytometry Activity/Platform. She has been using her experience and expertise to develop new methods and applications of existing equipment, ensure the implementation of new, emerging technologies for flow cytometry and to provide excellence in training and teaching of the community. **Education** Ingénieur, Expert en Ingénierie de Biotechnologies,(BAC+5, Supbiotech). Licence/Certificat d’Etudes Spécialisées en Recherche Biomédicale «option Immunologie». Brevet de Technicien Supérieur en « Analyses biologiques ».ESTBA Baccalauréat D.Lycée Condorcet **Professional experience** 2016- present Institut Pasteur, Paris, Responsible for Flow Cytometry platform of the CB UTechS 2014-2016 Institut Pasteur, Paris, Head of Flow Cytometry platform 2010-2013 BD Biosciences, Europe, Coordinator of the Training Center France **Technical Skills** Fields of expertise: flow cytometry, cell sorting, high-end flow instrumentation, training and education, fluorescence, multi-dimensional data analysis, single cell applications of flow cytometry, different techniques of cell biology and immunology. **Teaching Activities** 2015 – present Institut Pasteur (with Universities Paris V, VI and VII) “Advanced course of Immunology program” for M2 students 2017 – present Institut Pasteur (with the HR Training department) “Basics of Flow Cytometry and Cell sorting” Organizer and teacher in the 1-week long Theoretical and Practical Work 2018 ISAC international workshop Co-organizer and teacher in the 3-weeks long Practical Work **Associations & Membership:** 2018 – present Member of Core for Life, European Cytometry working group 2017 – present 2018 – present Member of Core Technologies for Life Sciences (CTLS) 2015 – present Member of International Association of Advanced Cytometry (ISAC) 2015 – present Member of Association Française de Cytométrie (AFC)


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High-Quality Brain and Bone Marrow Nuclei Preparation for Single Nuclei Multiome Assays

Carolina Moraes-Cabe , Sophie Novault , Ana Jeemin Choi , Valerie Seffer , Laura Barrio Cano
Journal of visualized experiments : JoVE, 2023, 202, pp.e65715. ⟨10.3791/65715⟩
Journal articles pasteur-04362729v1
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T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

Céline Cuche , Marta Mastrogiovanni , Marie Juzans , Hélène Laude , Marie-Noëlle Ungeheuer
Frontiers in Immunology, 2023, 14, pp.1163466. ⟨10.3389/fimmu.2023.1163466⟩
Journal articles pasteur-04185525v1
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Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans

Juliana Rizzo , Adèle Trottier , Frédérique Moyrand , Jean-Yves J.-Y. Coppée , Corinne Maufrais
mBio, 2023, pp.e00870-23. ⟨10.1128/mbio.00870-23⟩
Journal articles pasteur-04134001v1
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TATTOO-seq delineates spatial and cell type–specific regulatory programs in the developing limb

Sébastien Bastide , Elad Chomsky , Baptiste Saudemont , Yann Loe-Mie , Sandrine Schmutz
Science Advances , 2022, 8 (50), ⟨10.1126/sciadv.add0695⟩
Journal articles pasteur-04081196v1
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Changes in Systemic Regulatory T Cells, Effector T Cells, and Monocyte Populations Associated With Early-Life Stunting

Zo Andriamanantena , Fanirisoa Randrianarisaona , Maheninasy Rakotondrainipiana , Prisca Andriantsalama , Ravaka Randriamparany
Frontiers in Immunology, 2022, 13, pp.864084. ⟨10.3389/fimmu.2022.864084⟩
Journal articles pasteur-03714245v1
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Identification of fetal liver stroma in spectral cytometry using the parameter autofluorescence†

Marcia Mesquita Peixoto , Francisca Soares‐da‐silva , Sandrine Schmutz , Marie‐pierre Mailhe , Sophie Novault
Cytometry Part A, 2022, ⟨10.1002/cyto.a.24567⟩
Journal articles pasteur-03663861v1
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Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Amaia Dominguez-Belloso , Sandrine Schmutz , Sophie Novault , Aleksandra Deczkowska , Laetitia Travier
Journal of visualized experiments : JoVE, 2022, 180, ⟨10.3791/63487⟩
Journal articles pasteur-03560536v1

Flow Cytometry Analysis of HIV-1 Env Conformations at the Surface of Infected Cells and Virions: Role of Nef, CD4, and SERINC5

Isabelle Staropoli , Jérémy Dufloo , Anaïs Ducher , Pierre-Henri Commère , Anna Sartori-Rupp
Journal of Virology, 2020, 94 (6), ⟨10.1128/JVI.01783-19⟩
Journal articles pasteur-02561978v1

Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq

Arnau Sebé-Pedrós , Baptiste Saudemont , Elad Chomsky , Flora Plessier , Marie-Pierre Mailhé
Cell, 2018, 173 (6), pp.1520 - 1534.e20. ⟨10.1016/j.cell.2018.05.019⟩
Journal articles pasteur-01838472v1
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Analysis of Cell Suspensions Isolated from Solid Tissues by Spectral Flow Cytometry

Sandrine Schmutz , Mariana Valente , Ana Cumano , Sophie Novault
Journal of visualized experiments : JoVE, 2017, 123, ⟨10.3791/55578⟩
Journal articles pasteur-02562814v1
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Spectral Cytometry Has Unique Properties Allowing Multicolor Analysis of Cell Suspensions Isolated from Solid Tissues

Sandrine Schmutz , Mariana Valente , Ana Cumano , Sophie Novault
PLoS ONE, 2016, 11 (8), pp.e0159961. ⟨10.1371/journal.pone.0159961⟩
Journal articles pasteur-01392620v1
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Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα

Sophie Viaud , Magali Terme , Caroline Flament , Julien Taieb , Fabrice André
PLoS ONE, 2009, 4 (3), pp.e4942. ⟨10.1371/journal.pone.0004942⟩
Journal articles pasteur-03360096v1
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CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner.

François Ghiringhelli , Cédric Ménard , Magali Terme , Caroline Flament , Julien Taieb
Journal of Experimental Medicine, 2007, 202 (8), pp.1075-85. ⟨10.1084/jem.20051511⟩
Journal articles pasteur-00020140v1

Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based Vaccines

Julien Taieb , Nathalie Chaput , Noël Schartz , Stéphan Roux , Sophie Novault
Journal of Immunology, 2006, 176 (5), pp.2722-2729. ⟨10.4049/jimmunol.176.5.2722⟩
Journal articles pasteur-03360098v1
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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial.

Bernard Escudier , Thierry Dorval , Nathalie Chaput , Fabrice André , Marie-Pierre Caby
J Transl Med, 2005, 3, pp.10. ⟨10.1186/1479-5876-3-10⟩
Journal articles inserm-00092539v1

The potential of exosomes in immunotherapy of cancer

Nathalie Chaput , Julien Taïeb , Noël Schartz , Caroline Flament , Sophie Novault
Blood Cells, Molecules and Diseases, 2005, 35 (2), pp.111-115. ⟨10.1016/j.bcmd.2005.05.009⟩
Journal articles pasteur-03360103v1