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Stephanie Le Gras

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Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase

Lucía Ramos-Alonso , Petter Holland , Stéphanie Le Gras , Xu Zhao , Bernard Jost
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (4), ⟨10.1073/pnas.2210593120⟩
Journal articles hal-04098268v1
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Analysis of the P. lividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes

Ferdinand Marlétaz , Arnaud Couloux , Julie Poulain , Karine Labadie , Corinne da Silva
Cell Genomics, 2023, 3 (4), pp.100295. ⟨10.1016/j.xgen.2023.100295⟩
Journal articles hal-04093287v1
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Waves of sumoylation support transcription dynamics during adipocyte differentiation

Xu Zhao , Ivo A Hendriks , Stéphanie Le Gras , Tao Ye , Lucía Ramos-Alonso
Nucleic Acids Research, 2022, 50 (3), pp.1351-1369. ⟨10.1093/nar/gkac027⟩
Journal articles hal-03716138v1
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TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

Moïra Rossitto , Stephanie Déjardin , Chris M Rands , Stephanie Le Gras , Roberta Migale
Nature Communications, 2022, 13 (1), pp.4412. ⟨10.1038/s41467-022-32061-1⟩
Journal articles hal-03746540v1
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Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation

Emeline Fontaine , Christophe Papin , Guillaume Martinez , Stéphanie Le Gras , Roland Abi Nahed
Nucleic Acids Research, 2022, 50 (13), pp.7350-7366. ⟨10.1093/nar/gkac541⟩
Journal articles hal-03852700v1
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Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and learning-dependent transcription

Isabel Paiva , Lucrezia Cellai , Céline Meriaux , Lauranne Poncelet , Ouada Nebie
The Journal of clinical investigation, 2022, 132 (12), ⟨10.1172/JCI149371⟩
Journal articles hal-03855350v1
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Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Edmone Dewaeles , Kévin Carvalho , Sandy Fellah , Jaewon Sim , Nihad Boukrout
The Journal of clinical investigation, 2022, 132 (22), pp.e152924. ⟨10.1172/JCI152924⟩
Journal articles inserm-03865945v1
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Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy

Anna Niewiadomska-Cimicka , Antoine Hache , Stéphanie Le Gras , Céline Keime , Tao Ye
Journal of Biomedical Science, 2022, 107, ⟨10.1186/s12929-022-00892-1⟩
Journal articles hal-03935562v1
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Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells

Jiang Zhang , Stéphanie Le Gras , Kevin Pouxvielh , Fabrice Faure , Lucie Fallone
Nature Communications, 2021, 12 (1), pp.5446. ⟨10.1038/s41467-021-25758-2⟩
Journal articles hal-03357265v1
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Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells

Giovanni Cova , Chiara Taroni , Marie-Céline Deau , Qi Cai , Vincent Mittelheisser
Journal of Experimental Medicine, 2021, 218 (10), pp.e20202317. ⟨10.1084/jem.20202317⟩
Journal articles hal-03375832v1
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Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

Nour El Houda Mimouni , Isabel Paiva , Anne Laure Barbotin , Fatima Ezzahra Timzoura , Damien Plassard
Cell Metabolism, 2021, 33 (3), pp.513-530.e8. ⟨10.1016/j.cmet.2021.01.004⟩
Journal articles hal-03427354v1
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Succinylation of H3K122 destabilizes nucleosomes and enhances transcription

Lara Zorro Shahidian , Mariska Haas , Stéphanie Le Gras , Sandra Nitsch , André Mourão
EMBO Reports, 2021, 22 (3), ⟨10.15252/embr.202051009⟩
Journal articles hal-03713626v1

CpG Islands Shape the Epigenome Landscape

Christophe Papin , Stéphanie Le Gras , Abdulkhaleg Ibrahim , Hatem Salem , Mohammad Mahdi Karimi
Journal of Molecular Biology, 2021, 433 (6), pp.166659. ⟨10.1016/j.jmb.2020.09.018⟩
Journal articles hal-03450118v1

MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion

Abdulkhaleg Ibrahim , Christophe Papin , Kareem Mohideen-Abdul , Stéphanie Le Gras , Isabelle Stoll
Science, 2021, 372 (6549), ⟨10.1126/science.abd5581⟩
Journal articles inserm-03376640v1

Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process

Nour El Houda Mimouni , Isabel Paiva , Anne-Laure Barbotin , Fatima Ezzahra Timzoura , Damien Plassard
Cell Metabolism, 2021, 33 (3), pp.513-530.e8. ⟨10.1016/j.cmet.2021.01.004⟩
Journal articles hal-04161337v1
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CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma

Pietro Berico , Max Cigrang , Guillaume Davidson , Cathy Braun , Jeremy Sandoz
EMBO Reports, 2021, 22 (9), pp.e51683. ⟨10.15252/embr.202051683⟩
Journal articles inserm-03336903v1
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Ikaros antagonizes DNA binding by STAT5 in pre-B cells

Beate Heizmann , Stéphanie Le Gras , Célestine Simand , Patricia Marchal , Susan Chan
PLoS ONE, 2020, 15 (11), pp.e0242211. ⟨10.1371/journal.pone.0242211⟩
Journal articles hal-03665603v1
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Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

Adam Burton , Vincent Brochard , Carmen Galán , Elias Ruiz-Morales , Quirze Rovira
Nature Cell Biology, 2020, 22 (7), pp.767-778. ⟨10.1038/s41556-020-0536-6⟩
Journal articles hal-02903653v1
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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Kevin Carvalho , Emilie Faivre , Marie Pietrowski , Xavier Marques , Victoria Gomez-Murcia
Brain - A Journal of Neurology , 2019, 142 (11), pp.3636-3654. ⟨10.1093/brain/awz288⟩
Journal articles inserm-02350065v1
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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

Nicolas Merienne , Cécile Meunier , Anne Schneider , Jonathan Seguin , Satish Nair
Cell Reports, 2019, 26 (9), pp.2477-2493.e9. ⟨10.1016/j.celrep.2019.02.003⟩
Journal articles hal-02087719v1
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Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

Snehajyoti Chatterjee , Raphaelle Cassel , Anne Schneider‐anthony , Karine Mérienne , Brigitte Cosquer
EMBO Molecular Medicine, 2018, 10 (11), pp.e8587. ⟨10.15252/emmm.201708587⟩
Journal articles inserm-01930486v1

Genes and Pathways Regulated by Androgens in Human Neural Cells, Potential Candidates for the Male Excess in Autism Spectrum Disorder

Angélique Quartier , Laure Chatrousse , Claire Redin , Céline Keime , Nicolas Haumesser
Biological psychiatry, 2018, 84 (4), pp.239-252. ⟨10.1016/j.biopsych.2018.01.002⟩
Journal articles hal-03670936v1

La médiation corporelle dans la prise en charge globale de jeunes souffrant d’anorexie mentale

Catherine Saez , Laurence Suelves , Marie Deguitre , Blandine Deffinis , Marie-Jeanne Calmels
Soins Pédiatrie/Puériculture, 2018, 39 (303), pp.38-43. ⟨10.1016/j.spp.2018.05.009⟩
Journal articles hal-02316819v1
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Macrophage production and activation are dependent on TRIM33

Anne-Sophie Gallouet , Federica Ferri , Vanessa Petit , Aude Parcelier , Daniel Lewandowski
Oncotarget, 2017, 8 (3), pp.5111-5122. ⟨10.18632/oncotarget.13872⟩
Journal articles hal-03677820v1
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Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature

Stéphanie Le Gras , Céline Keime , Anne Anthony , Caroline Lotz , Lucie de Longprez
Scientific Reports, 2017, 7 (Article number: 42875), ⟨10.1038/srep42875⟩
Journal articles cea-01751880v1

Histone propionylation is a mark of active chromatin

Adam Kebede , Anna Nieborak , Lara Zorro Shahidian , Stephanie Le Gras , Florian Richter
Nature Structural and Molecular Biology, 2017, 24 (12), pp.1048-1056. ⟨10.1038/nsmb.3490⟩
Journal articles hal-03985649v1
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TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo

Shilpy Joshi , Guillaume Davidson , Stéphanie Le Gras , Shuichi Watanabe , Thomas Braun
PLoS Genetics, 2017, 13 (2), pp.e1006600. ⟨10.1371/journal.pgen.1006600⟩
Journal articles hal-03524880v1
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The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility

Teddy Jegu , Alaguraj Veluchamy , Juan Sebastien Ramirez Prado , Charley Rizzi Paillet , Magali Perez
Genome Biology, 2017, 18, pp.114. ⟨10.1186/s13059-017-1246-7⟩
Journal articles hal-02627578v1
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MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity

David Latrasse , Teddy Jegu , Huchen Li , Axel de Julien de Zelicourt , Cécile Raynaud
Genome Biology, 2017, 18, pp.131. ⟨10.1186/s13059-017-1261-8⟩
Journal articles hal-02627216v1

Histone propionylation is a mark of active chromatin

Adam Kebede , Anna Nieborak , Lara Shahidian , Stéphanie Le Gras , Florian Richter
Nature Structural and Molecular Biology, 2017, ⟨10.1038/nsmb.3490⟩
Journal articles hal-03677811v1

Combinatorial DNA methylation codes at repetitive elements

Ali Hamiche , Christophe Papin , Abdulkhaleg Ibrahim , Stéphanie Le Gras , Amandine Velt
Genome Research, 2017, 27 (6), pp.934-946. ⟨10.1101/gr.213983.116⟩
Journal articles hal-03484320v1

A targeted next-generation sequencing assay for the molecular diagnosis of genetic disorders with orodental involvement

Megana Prasad , Véronique Geoffroy , Serge Vicaire , Bernard Jost , Michael Dumas
Journal of Medical Genetics, 2016, 53 (2), pp.98-110. ⟨10.1136/jmedgenet-2015-103302⟩
Journal articles hal-03825993v1
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A targeted next-generation sequencing assay for the molecular diagnosis of genetic disorders with orodental involvement

Megana K. Prasad , Véronique Geoffroy , Serge Vicaire , Bernard Jost , Michael Dumas
Journal of Medical Genetics, 2016, 53 (2), pp.98--110. ⟨10.1136/jmedgenet-2015-103302⟩
Journal articles hal-01272929v1
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Genome-wide mapping of collier In vivo binding sites highlights its hierarchical position in different transcription regulatory networks

Mathilde de Taffin , Yannick Carrier , Laurence Dubois , Laetitia Bataillé , Anaïs Painset
PLoS ONE, 2015, 10 (7), ⟨10.1371/journal.pone.0133387⟩
Journal articles hal-02634392v1

Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice

M. Achour , S. Le Gras , C. Keime , F. Parmentier , F. Lejeune
Human Molecular Genetics, 2015, 24 (12), pp.3481-3496. ⟨10.1093/hmg/ddv099⟩
Journal articles hal-02106606v1
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TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

Daniil Alpern , Diana Langer , Benoit Ballester , Stephanie Le Gras , Christophe Romier
eLife, 2014, 3, pp.308-312. ⟨10.7554/eLife.03613.001⟩
Journal articles hal-01404987v1
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An integrated diagnosis strategy for congenital myopathies.

Johann Böhm , Nasim Vasli , Edoardo Malfatti , Stéphanie Le Gras , Claire Feger
PLoS ONE, 2013, 8 (6), pp.e67527. ⟨10.1371/journal.pone.0067527⟩
Journal articles inserm-00904638v1
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Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation

Hélène Neyret-Kahn , Moussa Benhamed , Tao Ye , Stéphanie Le Gras , Jack-Christophe Cossec
Genome Research, 2013, 23 (10), pp.1563-1579. ⟨10.1101/gr.154872.113⟩
Journal articles pasteur-03235077v1

Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA

Anas Fadloun , Stéphanie Le Gras , Bernard Jost , Céline Ziegler-Birling , H Takahashi
Nature Structural and Molecular Biology, 2013, 20 (3), pp.332-338. ⟨10.1038/nsmb.2495⟩
Journal articles hal-04119882v1

Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

T Strub , S. Giuliano , T Ye , C Bonet , C. Keime
Oncogene, 2011, 30 (20), pp.2319-2332. ⟨10.1038/onc.2010.612⟩
Journal articles inserm-02530755v1

Genome-wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene

Dominique Kobi , Anne-Lise Steunou , Doulaye Dembélé , Stéphanie Le Gras , Lionel Larue
Pigment Cell & Melanoma research, 2010, 23 (3), pp.404-418. ⟨10.1111/j.1755-148X.2010.00697.x⟩
Journal articles hal-04042071v1

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL

Robin Jeannet , Jérôme Mastio , Alejandra Macias Garcia , Attila Oravecz , Todd Ashworth
Blood, 2010, 116 (25), pp.5443-5454. ⟨10.1182/blood-2010-05-286658⟩
Journal articles hal-04065527v1
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Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells.

Igor Martianov , Mohamed-Amin Choukrallah , Arnaud Krebs , Tao Ye , Stephanie Legras
BMC Genomics, 2010, 11 (1), pp.530. ⟨10.1186/1471-2164-11-530⟩
Journal articles inserm-00663886v1

Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes

Philippe Kastner , Susan Chan , Walter Vogel , Ling-Juan Zhang , Acharawan Topark-Ngarm
European Journal of Immunology, 2010, 40 (8), pp.2143-2154. ⟨10.1002/eji.200940258⟩
Journal articles hal-04009063v1

A Strategy for Direct Mapping and Identification of Mutations by Whole-Genome Sequencing

Steven Zuryn , Stéphanie Le Gras , Karine Jamet , Sophie Jarriault
Genetics, 2010, 186 (1), pp.427-430. ⟨10.1534/genetics.110.119230⟩
Journal articles hal-03036122v1