Pascal MARTIN

CNRS researcher, team leader of Institut Curie.
43
Documents
Affiliations actuelles
  • Laboratoire Physico-Chimie Curie [Institut Curie] (PCC)
  • Physique des Cellules et Cancer = Physics of Cells and Cancer (PCC)
Identifiants chercheurs

Présentation

ACADEMIC CURRICULUM:

  • 1989 to 1993: undergraduate studies in both Physics and Chemistry at the Ecole Supérieure de Physique et Chimie Industrielle de la ville de Paris (ESPCI Paris, France).
  • 1993: Master degree in soft-matter physics.
  • 1993-1994: "scientifique du contingent" (military service). Laboratoire Physico-Chimie Curie (PCC), Institut Curie, Paris, France.
  • 1994-1997: PhD in Physics from Université Pierre et Marie Curie (UPMC, now called Sorbonne Université, Paris, France). Dewetting of thin liquid films squeezed between a rigid plate and an elastomer. The PhD was funded by the Michelin tyre company and performed under the supervision of Prof Françoise Brochard-Wyart (PCC, Institut Curie, Paris).
  • 1997-2000: postdoc under the supervision of Prof Jim Hudspeth (Laboratory of Sensory Neuroscience, the Rockefeller University, New York, USA). Active mechanical properties of hair cells, the sensor and amplifiers of the inner ear.
  • 2000-present: CNRS researcher and principal inverstigator. Hair-cell biophysics and acto-myosin molecular systems (PCC, Institut Curie, Paris, France).

RESEARCH SUMMARY: Pascal Martin has developed micromechanical tools to study the active (tension, spontaneous oscillations) and passive (stiffness, friction) mechanical properties of the hair bundle--the mechanosensory antenna of the hair cells in the vertebrate inner ear. In close collaboration with theorists, he has combined experiments and physical models to study the various regimes of active hair-bundle motility as well as the effects of intrinsic noise, friction, and elastic coupling on hair-bundle mechanosensitivity. In parallel, he has developed minimal molecular systems comprising purified myosin molecular motors and actin filaments, demonstrating that spontaneous mechanical oscillations and wave-like beating can emerge from from dynamic instabilities in motor-filament systems. A similar biomimetic approach was also developed to study active transport and positioning of colloidal particles by molecular motors in antiparallel filament networks .


Publications

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Publications

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The Critical Thing about the Ear's Sensory Hair Cells

A.J. Hudspeth , Pascal Martin

Journal of Neuroscience, 2024, 44 (44), pp.e1583242024. ⟨10.1523/JNEUROSCI.1583-24.2024⟩

Article dans une revue hal-05387704v1
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Evolving critical oscillators for hearing

A.J. Hudspeth , Pascal Martin

Nature Reviews Physics, 2023, 6 (4), pp.210-211. ⟨10.1038/s42254-023-00672-2⟩

Article dans une revue hal-04337195v1
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Flagella-like beating of actin bundles driven by self-organized myosin waves

Marie Pochitaloff , Martin Miranda , Mathieu Richard , Atitheb Chaiyasitdhi , Yasuharu Takagi et al.

Nature Physics, 2022, 18 (10), pp.1240. ⟨10.1038/s41567-022-01688-8⟩

Article dans une revue hal-03748988v1
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Mechanical Frequency Tuning by Sensory Hair Cells, the Receptors and Amplifiers of the Inner Ear

Pascal Martin , A.J. Hudspeth

Annual Review of Condensed Matter Physics, 2021, 12 (1), ⟨10.1146/annurev-conmatphys-061020-053041⟩

Article dans une revue hal-03036747v1
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Quantifying entropy production in active fluctuations of the hair-cell bundle from time irreversibility and uncertainty relations

Édgar Roldán , Jérémie Barral , Pascal Martin , Juan Parrondo , Frank Jülicher

New Journal of Physics, 2021, 23 (8), pp.083013. ⟨10.1088/1367-2630/ac0f18⟩

Article dans une revue hal-03427220v2
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Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles

R. G Alonso , M. Tobin , Pascal Martin , A. J Hudspeth

Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (48), pp.30722-30727. ⟨10.1073/pnas.2016858117⟩

Article dans une revue hal-03076231v1
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Active cargo positioning in antiparallel transport networks

Mathieu Richard , Carles Blanch-Mercader , Hajer Ennomani , Wenxiang Cao , Enrique de La Cruz et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (30), pp.14835-14842. ⟨10.1073/pnas.1900416116⟩

Article dans une revue hal-02185109v1
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Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea

Mélanie Tobin , Atitheb Chaiyasitdhi , Vincent Michel , Nicolas Michalski , Pascal Martin

eLife, 2019, 8, pp.e43473. ⟨10.7554/eLife.43473⟩

Article dans une revue pasteur-02874559v1
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Friction from Transduction Channels’ Gating Affects Spontaneous Hair-Bundle Oscillations

Jérémie Barral , Frank Julicher , Pascal Martin

Biophysical Journal, 2018, 114 (2), pp.425-436. ⟨10.1016/j.bpj.2017.11.019⟩

Article dans une revue hal-01730607v1

Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear

Volker Bormuth , Jeremie Barral , J.-F. Joanny , Frank Juelicher , Pascal Martin

Proc Natl Acad Sci U S A, 2014, 111 (20), pp.7185-7190. ⟨10.1073/pnas.1402556111⟩

Article dans une revue hal-03299978v1
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Fluctuation-Response Theorem for the Active Noisy Oscillator of the Hair-Cell Bundle

L. Dinis , Pascal Martin , J. Barral , J. Prost , J.-F. Joanny

Physical Review Letters, 2012, 109 (16), pp.160602. ⟨10.1103/PhysRevLett.109.160602⟩

Article dans une revue hal-03299974v1

Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle

Jérémie Barral , Pascal Martin

Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (21), ⟨10.1073/pnas.1202426109⟩

Article dans une revue hal-03771351v1

The physical basis of active mechanosensitivity by the hair-cell bundle

Jérémie Barral , Pascal Martin

Current Opinion in Otolaryngology & Head and Neck Surgery, 2011, 19 (5), pp.369-375. ⟨10.1097/MOO.0b013e32834a8c33⟩

Article dans une revue hal-03771387v1

A Critique of the Critical Cochlea: Hopf—a Bifurcation—Is Better Than None

A. Hudspeth , Frank Jülicher , Pascal Martin

Journal of Neurophysiology, 2010, 104 (3), pp.1219-1229. ⟨10.1152/jn.00437.2010⟩

Article dans une revue hal-03771390v1

The remarkable cochlear amplifier

J. Ashmore , P. Avan , W.E. Brownell , P. Dallos , K. Dierkes et al.

Hearing Research, 2010, 266 (1-2), pp.1-17. ⟨10.1016/j.heares.2010.05.001⟩

Article dans une revue hal-03771392v1

Coupling a sensory hair-cell bundle to cyber clones enhances nonlinear amplification

Jérémie Barral , Kai Dierkes , Benjamin Lindner , Frank Jülicher , Pascal Martin

Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (18), pp.8079-8084. ⟨10.1073/pnas.0913657107⟩

Article dans une revue hal-03771397v1

Spontaneous Oscillations of a Minimal Actomyosin System Under Elastic Loading

Pierre-Yves Placais , Martial Balland , Thomas Guérin , Jean-François Joanny , Pascal Martin

Physical Review Letters, 2010, 103 (15), pp.158102. ⟨10.1103/PhysRevLett.103.158102⟩

Article dans une revue hal-01659711v1

Coordination and collective properties of molecular motors: theory

Thomas Guérin , J. Prost , Pascal Martin , Jean-François Joanny

Current Opinion in Cell Biology, 2010, 22 (1), pp.14-20. ⟨10.1016/j.ceb.2009.12.012⟩

Article dans une revue istex hal-01659698v1

Spontaneous movements and linear response of a noisy oscillator

F. Jülicher , K. Dierkes , B. Lindner , J. Prost , Pascal Martin

European Physical Journal E: Soft matter and biological physics, 2009, 29 (4), pp.449-460. ⟨10.1140/epje/i2009-10487-5⟩

Article dans une revue hal-03771628v1
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Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells

Nicolas Michalski , Vincent Michel , Elisa Caberlotto , Gaëlle Lefèvre , Alexander van Aken et al.

Pflügers Archiv European Journal of Physiology, 2009, 459 (1), pp.115-130. ⟨10.1007/s00424-009-0711-x⟩

Article dans une revue pasteur-02616476v1

Two-state approach to stochastic hair bundle dynamics

Diana Clausznitzer , Benjamin Lindner , Frank Jülicher , Pascal Martin

Physical Review E : Statistical, Nonlinear, and Soft Matter Physics [2001-2015], 2008, 77 (4), pp.041901. ⟨10.1103/PhysRevE.77.041901⟩

Article dans une revue hal-03771490v1

Unifying the Various Incarnations of Active Hair-Bundle Motility by the Vertebrate Hair Cell

Jean-Yves Tinevez , Frank Julicher , Pascal Martin

Biophysical Journal, 2007, 93 (11), pp.4053-4067. ⟨10.1529/biophysj.107.108498⟩

Article dans une revue hal-02616477v1

Molecular Characterization of the Ankle-Link Complex in Cochlear Hair Cells and Its Role in the Hair Bundle Functioning

N. Michalski , V. Michel , A. Bahloul , G. Lefevre , J. Barral et al.

Journal of Neuroscience, 2007, 27 (24), pp.6478-6488. ⟨10.1523/JNEUROSCI.0342-07.2007⟩

Article dans une revue hal-03771502v1

Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity

Björn Nadrowski , Pascal Martin , Frank Jülicher

Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (33), pp.12195-12200. ⟨10.1073/pnas.0403020101⟩

Article dans une revue hal-03771507v1

Spontaneous Oscillation by Hair Bundles of the Bullfrog's Sacculus

Pascal Martin , D. Bozovic , Y. Choe , A. Hudspeth

Journal of Neuroscience, 2003, 23 (11), pp.4533-4548. ⟨10.1523/JNEUROSCI.23-11-04533.2003⟩

Article dans une revue hal-03771618v1

Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process

Pascal Martin , A. Hudspeth , F. Jülicher

Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (25), pp.14380-14385. ⟨10.1073/pnas.251530598⟩

Article dans une revue hal-03771606v1
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Adhesion of soft objects on wet substrates

Françoise Brochard-Wyart , Axel Buguin , Pascal Martin , Arnaud Martin , Olivier Sandre

Journal of Physics: Condensed Matter, 2000, 12 (8A), pp.A239-A244. ⟨10.1088/0953-8984/12/8A/330⟩

Article dans une revue hal-02168817v1

Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell

Pascal Martin , A. Mehta , A. Hudspeth

Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (22), pp.12026-12031. ⟨10.1073/pnas.210389497⟩

Article dans une revue hal-03771516v1

Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells

A. Hudspeth , Y. Choe , A. Mehta , Pascal Martin

Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (22), pp.11765-11772. ⟨10.1073/pnas.97.22.11765⟩

Article dans une revue hal-03771513v1

Active hair-bundle movements can amplify a hair cell’s response to oscillatory mechanical stimuli

Pascal Martin , A. Hudspeth

Proceedings of the National Academy of Sciences of the United States of America, 1999, 96 (25), pp.14306-14311. ⟨10.1073/pnas.96.25.14306⟩

Article dans une revue hal-03771533v1

Dewetting at Soft Interfaces

Pascal Martin , Françoise Brochard-Wyart

Physical Review Letters, 1998, 80 (15), pp.3296-3299. ⟨10.1103/PhysRevLett.80.3296⟩

Article dans une revue hal-03771546v1

Dewetting of Supported Viscoelastic Polymer Films: Birth of Rims

F. Brochard-Wyart , G. Debregeas , R. Fondecave , Pascal Martin

Macromolecules, 1997, 30 (4), pp.1211-1213. ⟨10.1021/MA960929X⟩

Article dans une revue istex hal-03771566v1

Sessile Droplets at a Solid/Elastomer Interface

Pascal Martin , P. Silberzan , F. Brochard-Wyart

Langmuir, 1997, 13 (18), pp.4910-4914. ⟨10.1021/la9703151⟩

Article dans une revue istex hal-03771555v1

Viscous Bursting of Suspended Films

G. Debrégeas , Pascal Martin , F. Brochard-Wyart

Physical Review Letters, 1995, 75 (21), pp.3886-3889. ⟨10.1103/PhysRevLett.75.3886⟩

Article dans une revue hal-03771593v1

Bursting of a Liquid Film on a Liquid Substrate

Pascal Martin , A Buguin , F Brochard-Wyart

EPL - Europhysics Letters, 1994, 28 (6), pp.421-426. ⟨10.1209/0295-5075/28/6/008⟩

Article dans une revue istex hal-03771577v1

Liquid/liquid dewetting

Francoise Brochard Wyart , Pascal Martin , Claude Redon

Langmuir, 1993, 9 (12), pp.3682-3690. ⟨10.1021/la00036a053⟩

Article dans une revue istex hal-03771585v1
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The transepithelial potential can control gating compliance of the hair-cell bundle

A. Joliot , P. Martin

NONLINEARITY AND HEARING: ADVANCES IN THEORY AND EXPERIMENT: Proceedings of the 14th International Mechanics of Hearing Workshop, Jul 2022, Helsingør, Denmark. pp.050006, ⟨10.1063/5.0189296⟩

Communication dans un congrès hal-05387871v1
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The Endolymphatic Potential Can Control the Gating Force of the Hair Cell's Transduction Channels

Achille Joliot , Pascal Martin

Mechanics of Hearing Workshop 2024, Jun 2024, Ann Harbor - Michigan, United States. ⟨10.5281/zenodo.13336409⟩

Communication dans un congrès hal-04797671v1
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Nonlinear Tuning from Coupled Critical Oscillators in a Travelling-Wave Model of The Cochlea

Henri Ver Hulst , Carles Blanch-Mercader , Pascal Martin

Mechanics of Hearing Workshop 2024, Jun 2024, Ann Harbor - Michigan, United States. ⟨10.5281/zenodo.13342228⟩

Communication dans un congrès hal-04799635v1

Auditory processing by the cochlea

Pascal Martin , Geoffrey A. Manley

Eric R. Kandel; Steven A. Siegelbaum; Sarah H. Mack; John Koester,. Principles of neural science, McGraw-Hill Education / Medical; 6th edition, pp.594-624, 2021, 978-1-259-64223-4

Chapitre d'ouvrage hal-04037337v1