Pascal MARTIN

40
Documents
Affiliations actuelles
  • Laboratoire Physico-Chimie Curie [Institut Curie] (PCC)
  • Physique des Cellules et Cancer = Physics of Cells and Cancer (PCC)
Identifiants chercheurs

Présentation

ACADEMIC CURRICULUM:

  • 1989 to 1993: undergraduate studies in both Physics and Chemistry at the Ecole Supérieure de Physique et Chimie Industrielle de la ville de Paris (ESPCI Paris, France).
  • 1993: Master degree in soft-matter physics.
  • 1993-1994: "scientifique du contingent" (military service). Laboratoire Physico-Chimie Curie (PCC), Institut Curie, Paris, France.
  • 1994-1997: PhD in Physics from Université Pierre et Marie Curie (UPMC, now called Sorbonne Université, Paris, France). Dewetting of thin liquid films squeezed between a rigid plate and an elastomer. The PhD was funded by the Michelin tyre company and performed under the supervision of Prof Françoise Brochard-Wyart (PCC, Institut Curie, Paris).
  • 1997-2000: postdoc under the supervision of Prof Jim Hudspeth (Laboratory of Sensory Neuroscience, the Rockefeller University, New York, USA). Active mechanical properties of hair cells, the sensor and amplifiers of the inner ear.
  • 2000-present: CNRS researcher and principal inverstigator. Hair-cell biophysics and acto-myosin molecular systems (PCC, Institut Curie, Paris, France).

RESEARCH SUMMARY: Pascal Martin has developed micromechanical tools to study the active (tension, spontaneous oscillations) and passive (stiffness, friction) mechanical properties of the hair bundle--the mechanosensory antenna of the hair cells in the vertebrate inner ear. In close collaboration with theorists, he has combined experiments and physical models to study the various regimes of active hair-bundle motility as well as the effects of intrinsic noise, friction, and elastic coupling on hair-bundle mechanosensitivity. In parallel, he has developed minimal molecular systems comprising purified myosin molecular motors and actin filaments, demonstrating that spontaneous mechanical oscillations and wave-like beating can emerge from from dynamic instabilities in motor-filament systems. A similar biomimetic approach was also developed to study active transport and positioning of colloidal particles by molecular motors in antiparallel filament networks .


Publications

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Publications

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Evolving critical oscillators for hearing

A.J. Hudspeth , Pascal Martin
Nature Reviews Physics, 2023, 6 (4), pp.210-211. ⟨10.1038/s42254-023-00672-2⟩
Article dans une revue hal-04337195 v1
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Flagella-like beating of actin bundles driven by self-organized myosin waves

Marie Pochitaloff , Martin Miranda , Mathieu Richard , Atitheb Chaiyasitdhi , Yasuharu Takagi et al.
Nature Physics, 2022, 18 (10), pp.1240. ⟨10.1038/s41567-022-01688-8⟩
Article dans une revue hal-03748988 v1
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Mechanical Frequency Tuning by Sensory Hair Cells, the Receptors and Amplifiers of the Inner Ear

Pascal Martin , A.J. Hudspeth
Annual Review of Condensed Matter Physics, 2021, 12 (1), ⟨10.1146/annurev-conmatphys-061020-053041⟩
Article dans une revue hal-03036747 v1
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Quantifying entropy production in active fluctuations of the hair-cell bundle from time irreversibility and uncertainty relations

Édgar Roldán , Jérémie Barral , Pascal Martin , Juan Parrondo , Frank Jülicher
New Journal of Physics, 2021, 23 (8), pp.083013. ⟨10.1088/1367-2630/ac0f18⟩
Article dans une revue hal-03427220 v2
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Fast recovery of disrupted tip links induced by mechanical displacement of hair bundles

R. G Alonso , M. Tobin , Pascal Martin , A. J Hudspeth
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (48), pp.30722-30727. ⟨10.1073/pnas.2016858117⟩
Article dans une revue hal-03076231 v1
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Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea

Mélanie Tobin , Atitheb Chaiyasitdhi , Vincent Michel , Nicolas Michalski , Pascal Martin
eLife, 2019, 8, pp.e43473. ⟨10.7554/eLife.43473⟩
Article dans une revue pasteur-02874559 v1
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Active cargo positioning in antiparallel transport networks

Mathieu Richard , Carles Blanch-Mercader , Hajer Ennomani , Wenxiang Cao , Enrique de La Cruz et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (30), pp.14835-14842. ⟨10.1073/pnas.1900416116⟩
Article dans une revue hal-02185109 v1
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Friction from Transduction Channels’ Gating Affects Spontaneous Hair-Bundle Oscillations

Jérémie Barral , Frank Julicher , Pascal Martin
Biophysical Journal, 2018, 114 (2), pp.425-436. ⟨10.1016/j.bpj.2017.11.019⟩
Article dans une revue hal-01730607 v1

Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear

Volker Bormuth , Jeremie Barral , J.-F. Joanny , Frank Juelicher , Pascal Martin
Proc Natl Acad Sci U S A, 2014, 111 (20), pp.7185-7190. ⟨10.1073/pnas.1402556111⟩
Article dans une revue hal-03299978 v1
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Fluctuation-Response Theorem for the Active Noisy Oscillator of the Hair-Cell Bundle

L. Dinis , Pascal Martin , J. Barral , J. Prost , J.-F. Joanny
Physical Review Letters, 2012, 109 (16), pp.160602. ⟨10.1103/PhysRevLett.109.160602⟩
Article dans une revue hal-03299974 v1

Phantom tones and suppressive masking by active nonlinear oscillation of the hair-cell bundle

Jérémie Barral , Pascal Martin
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (21), ⟨10.1073/pnas.1202426109⟩
Article dans une revue hal-03771351 v1

The physical basis of active mechanosensitivity by the hair-cell bundle

Jérémie Barral , Pascal Martin
Current Opinion in Otolaryngology & Head and Neck Surgery, 2011, 19 (5), pp.369-375. ⟨10.1097/MOO.0b013e32834a8c33⟩
Article dans une revue hal-03771387 v1

A Critique of the Critical Cochlea: Hopf—a Bifurcation—Is Better Than None

A. Hudspeth , Frank Jülicher , Pascal Martin
Journal of Neurophysiology, 2010, 104 (3), pp.1219-1229. ⟨10.1152/jn.00437.2010⟩
Article dans une revue hal-03771390 v1

The remarkable cochlear amplifier

J. Ashmore , P. Avan , W.E. Brownell , P. Dallos , K. Dierkes et al.
Hearing Research, 2010, 266 (1-2), pp.1-17. ⟨10.1016/j.heares.2010.05.001⟩
Article dans une revue hal-03771392 v1

Coupling a sensory hair-cell bundle to cyber clones enhances nonlinear amplification

Jérémie Barral , Kai Dierkes , Benjamin Lindner , Frank Jülicher , Pascal Martin
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (18), pp.8079-8084. ⟨10.1073/pnas.0913657107⟩
Article dans une revue hal-03771397 v1

Spontaneous Oscillations of a Minimal Actomyosin System Under Elastic Loading

Pierre-Yves Placais , Martial Balland , Thomas Guérin , Jean-François Joanny , Pascal Martin
Physical Review Letters, 2010, 103 (15), pp.158102. ⟨10.1103/PhysRevLett.103.158102⟩
Article dans une revue hal-01659711 v1

Coordination and collective properties of molecular motors: theory

Thomas Guérin , J. Prost , Pascal Martin , Jean-François Joanny
Current Opinion in Cell Biology, 2010, 22 (1), pp.14-20. ⟨10.1016/j.ceb.2009.12.012⟩
Article dans une revue istex hal-01659698 v1
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Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells

Nicolas Michalski , Vincent Michel , Elisa Caberlotto , Gaëlle Lefèvre , Alexander van Aken et al.
Pflügers Archiv European Journal of Physiology, 2009, 459 (1), pp.115-130. ⟨10.1007/s00424-009-0711-x⟩
Article dans une revue pasteur-02616476 v1

Spontaneous movements and linear response of a noisy oscillator

F. Jülicher , K. Dierkes , B. Lindner , J. Prost , Pascal Martin
European Physical Journal E: Soft matter and biological physics, 2009, 29 (4), pp.449-460. ⟨10.1140/epje/i2009-10487-5⟩
Article dans une revue hal-03771628 v1

Two-state approach to stochastic hair bundle dynamics

Diana Clausznitzer , Benjamin Lindner , Frank Jülicher , Pascal Martin
Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, 2008, 77 (4), pp.041901. ⟨10.1103/PhysRevE.77.041901⟩
Article dans une revue hal-03771490 v1

Molecular Characterization of the Ankle-Link Complex in Cochlear Hair Cells and Its Role in the Hair Bundle Functioning

N. Michalski , V. Michel , A. Bahloul , G. Lefevre , J. Barral et al.
Journal of Neuroscience, 2007, 27 (24), pp.6478-6488. ⟨10.1523/JNEUROSCI.0342-07.2007⟩
Article dans une revue hal-03771502 v1

Unifying the Various Incarnations of Active Hair-Bundle Motility by the Vertebrate Hair Cell

Jean-Yves Tinevez , Frank Julicher , Pascal Martin
Biophysical Journal, 2007, 93 (11), pp.4053-4067. ⟨10.1529/biophysj.107.108498⟩
Article dans une revue pasteur-02616477 v1

Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity

Björn Nadrowski , Pascal Martin , Frank Jülicher
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (33), pp.12195-12200. ⟨10.1073/pnas.0403020101⟩
Article dans une revue hal-03771507 v1

Spontaneous Oscillation by Hair Bundles of the Bullfrog's Sacculus

Pascal Martin , D. Bozovic , Y. Choe , A. Hudspeth
Journal of Neuroscience, 2003, 23 (11), pp.4533-4548. ⟨10.1523/JNEUROSCI.23-11-04533.2003⟩
Article dans une revue hal-03771618 v1

Comparison of a hair bundle's spontaneous oscillations with its response to mechanical stimulation reveals the underlying active process

Pascal Martin , A. Hudspeth , F. Jülicher
Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (25), pp.14380-14385. ⟨10.1073/pnas.251530598⟩
Article dans une revue hal-03771606 v1
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Adhesion of soft objects on wet substrates

Françoise Brochard-Wyart , Axel Buguin , Pascal Martin , Arnaud Martin , Olivier Sandre
Journal of Physics: Condensed Matter, 2000, 12 (8A), pp.A239-A244. ⟨10.1088/0953-8984/12/8A/330⟩
Article dans une revue hal-02168817 v1

Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells

A. Hudspeth , Y. Choe , A. Mehta , Pascal Martin
Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (22), pp.11765-11772. ⟨10.1073/pnas.97.22.11765⟩
Article dans une revue hal-03771513 v1

Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell

Pascal Martin , A. Mehta , A. Hudspeth
Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (22), pp.12026-12031. ⟨10.1073/pnas.210389497⟩
Article dans une revue hal-03771516 v1

Active hair-bundle movements can amplify a hair cell’s response to oscillatory mechanical stimuli

Pascal Martin , A. Hudspeth
Proceedings of the National Academy of Sciences of the United States of America, 1999, 96 (25), pp.14306-14311. ⟨10.1073/pnas.96.25.14306⟩
Article dans une revue hal-03771533 v1

Dewetting at Soft Interfaces

Pascal Martin , Françoise Brochard-Wyart
Physical Review Letters, 1998, 80 (15), pp.3296-3299. ⟨10.1103/PhysRevLett.80.3296⟩
Article dans une revue hal-03771546 v1

Dewetting of Supported Viscoelastic Polymer Films: Birth of Rims

F. Brochard-Wyart , G. Debregeas , R. Fondecave , Pascal Martin
Macromolecules, 1997, 30 (4), pp.1211-1213. ⟨10.1021/MA960929X⟩
Article dans une revue istex hal-03771566 v1

Sessile Droplets at a Solid/Elastomer Interface

Pascal Martin , P. Silberzan , F. Brochard-Wyart
Langmuir, 1997, 13 (18), pp.4910-4914. ⟨10.1021/la9703151⟩
Article dans une revue istex hal-03771555 v1

Viscous Bursting of Suspended Films

G. Debrégeas , Pascal Martin , F. Brochard-Wyart
Physical Review Letters, 1995, 75 (21), pp.3886-3889. ⟨10.1103/PhysRevLett.75.3886⟩
Article dans une revue hal-03771593 v1

Bursting of a Liquid Film on a Liquid Substrate

Pascal Martin , A Buguin , F Brochard-Wyart
EPL - Europhysics Letters, 1994, 28 (6), pp.421-426. ⟨10.1209/0295-5075/28/6/008⟩
Article dans une revue istex hal-03771577 v1

Liquid/liquid dewetting

Francoise Brochard Wyart , Pascal Martin , Claude Redon
Langmuir, 1993, 9 (12), pp.3682-3690. ⟨10.1021/la00036a053⟩
Article dans une revue istex hal-03771585 v1

Auditory processing by the cochlea

Pascal Martin , Geoffrey A. Manley
Eric R. Kandel; Steven A. Siegelbaum; Sarah H. Mack; John Koester,. Principles of neural science, McGraw-Hill Education / Medical; 6th edition, pp.594-624, 2021, 978-1-259-64223-4
Chapitre d'ouvrage hal-04037337 v1