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Thierry BESSON

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Contribution of Professor Charles Rees to the development of the chemistry of disulfur dichloride

Thierry Besson , Lidia S Konstntinova , Panayiotis A Koutentis , Oleg A Rakitin , Sivaprasad Sivadasan
ARKIVOC - Online Journal of Organic Chemistry, 2024, Commemorative Issue in Honor of Prof. Alan R. Katritzky and Prof. Charles Rees on the occasion of the 25th anniversary of the first publication of Arkivoc (Archive for Organic Chemistry), 2024 (1), ⟨10.24820/ark.5550190.p012.136⟩
Journal articles hal-04432826v1

Contribution of Professor Charles W. Rees to the development of the chemistry of disulfur dichloride

Thierry Besson , Lidia Konstantinova , Panayiotis Koutentis , Oleg Rakitin , Sivaprasad Sivadasan
ARKIVOC - Online Journal of Organic Chemistry, 2024, 2024 (1), ⟨10.24820/ark.5550190.p012.136⟩
Journal articles hal-04435494v1

Photocatalyst-Free, Visible-Light-Mediated C–H Perfluoroalkylation of Quinazolin-4(3H)-ones with perfluoroalkyl Iodides

Thomas Delouche , Abdoul Gadiry-Diallo , Thierry Besson , Sensuke Ogoshi , Corinne Fruit
Synthesis: Journal of Synthetic Organic Chemistry, 2023, 55 (21), pp.3670-3684. ⟨10.1055/a-2054-0482⟩
Journal articles hal-04421057v1
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Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core

Mihaela-Liliana Ţînţaş , Ludovic Peauger , Florent Alix , Cyril Papamicaël , Thierry Besson
Molecules, 2023, 28 (1), pp.36. ⟨10.3390/molecules28010036⟩
Journal articles hal-03922046v1
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Synthesis of Trifunctional Thiazole-Fused Anthranilonitrile and Anthranilic Acid Derivatives

Nathan Broudic , Alexandra Pacheco-Benichou , Corinne Fruit , Thierry Besson
Synthesis: Journal of Synthetic Organic Chemistry, 2023, 55 (20), pp.3263-3271. ⟨10.1055/a-2086-3015⟩
Journal articles hal-04421061v1
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A skills framework integrating professionally relevant medicinal chemistry proficiencies to strengthen the contemporary practice of pharmacy

C. Decombat , O. Duval , T. Besson , L. Bourel , M. Pudlo
Annales Pharmaceutiques Françaises, 2022, 80 (2), pp.176-186. ⟨10.1016/j.pharma.2021.07.001⟩
Journal articles hal-03581421v1
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Review on the Synthesis and Therapeutic Potential of Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives

Joana F. Campos , Thierry Besson , Sabine Berteina-Raboin
Pharmaceuticals, 2022, 15 (3), pp.352. ⟨10.3390/ph15030352⟩
Journal articles hal-03890845v1

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

Rahul Bhansali , Malini Rammohan , Paul Lee , Anouchka Laurent , Qiang Wen
Journal of Clinical Investigation, 2021, 131 (1), ⟨10.1172/JCI135937⟩
Journal articles hal-03117656v1
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Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts

Thierry Besson , Corinne Fruit
Pharmaceuticals, 2021, 14 (7), pp.661. ⟨10.3390/ph14070661⟩
Journal articles hal-03358321v1
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Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling

Joana Campos , Manon Cailler , Remi Claudel , Benjamin Prot , Sabine Berteina-Raboin
Molecules, 2021, 26 (4), pp.1074. ⟨10.3390/molecules26041074⟩
Journal articles hal-03190807v1
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Copper-Catalyzed C–H Arylation of Fused-Pyrimidinone Derivatives Using Diaryliodonium Salts

Alexandra Pacheco-Benichou , Eugénie Ivendengani , Ioannis Kostakis , Thierry Besson , Corinne Fruit
Catalysts, 2021, 11 (1), pp.28. ⟨10.3390/catal11010028⟩
Journal articles hal-03117643v1
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Microwave-Assisted Synthesis of Potential Bioactive Benzo-, Pyrido- or Pyrazino-thieno[3,2-d]pyrimidin-4-amine Analogs of MPC-6827

Yvonnick Loidreau , Marie-Renée Nourrisson , Corinne Fruit , Cécile Corbière , Pascal Marchand
Pharmaceuticals, 2020, 13 (9), pp.202. ⟨10.3390/ph13090202⟩
Journal articles hal-03001666v1

Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald–Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol

Joana Campos , Alexandra Pacheco-Benichou , Corinne Fruit , Thierry Besson , Sabine Berteina-Raboin
Synthesis: Journal of Synthetic Organic Chemistry, 2020, ⟨10.1055/s-0040-1707158⟩
Journal articles hal-03001681v1
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Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives

Yvonnick Loidreau , Carole Dubouilh-Benard , Marie-Renée Nourrisson , Nadège Loaëc , Laurent Meijer
Pharmaceuticals, 2020, 13 (5), pp.89. ⟨10.3390/ph13050089⟩
Journal articles hal-02612282v1

Diaryliodoniums Salts as Coupling Partners for Transition-Metal Catalyzed C- and N-Arylation of Heteroarenes

Alexandra Pacheco-Benichou , Thierry Besson , Corinne Fruit
Catalysts, 2020, 10 (5), pp.483. ⟨10.3390/catal10050483⟩
Journal articles hal-02557380v1

Harnessing a Novel Dyrk1a-Ablim2-MKL1 Regulatory Module in Megakaryocyte Morphogenesis to Enable Scalable Platelet "Pharming"

Kamaleldin Elagib , Ashton Brock , Goar Mosoyan , Cara Clementelli , Lorrie Delehanty
Blood, 2019, 134 (S1), pp.3250-3250. ⟨10.1182/blood-2019-129049⟩
Journal articles hal-02384958v1
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Crystal Structure of 6,7-Dihydro-5a,7a,13,14-tetraaza-pentaphene-5,8-dione

Jean Guillon , Maria de Fatima Pereira-Rosenfeld , Noël Pinaud , Thierry Besson , Valérie Thiéry
X-Ray Structure Analysis Online, 2019, 35 (10), pp.57-59. ⟨10.2116/xraystruct.35.57⟩
Journal articles hal-02330806v1
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Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A

Corinne Fruit , Florence Couly , Rahul Bhansali , Malini Rammohan , Mattias F. Lindberg
Pharmaceuticals, 2019, 12 (4), pp.185. ⟨10.3390/ph12040185⟩
Journal articles hal-02417254v1

DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A-Rearranged Acute Lymphoblastic Leukemia

Christian Hurtz , Gerald Wertheim , Rahul Bhansali , Anne Lehman , Grace Jeschke
Blood, 2019, 134 (S1), pp.2742-2742. ⟨10.1182/blood-2019-123475⟩
Journal articles hal-02417476v1
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26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

Patrick Dallemagne , Christophe Rochais , Pascal Marchand , Thierry Besson
Pharmaceuticals, 2019, 12 (2), pp.73. ⟨10.3390/ph12020073⟩
Journal articles hal-02330438v1
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Synthesis of 2-Mercapto-(2-Oxoindolin-3-Ylidene)Acetonitriles from 3-(4-Chloro-5H-1,2,3-Dithiazol-5-Ylidene)Indolin-2-ones

Boris Letribot , Régis Delatouche , Hervé Rouillard , Antoine Bonnet , Jean-René Chérouvrier
Molecules, 2018, 23 (6), pp.1390. ⟨10.3390/molecules23061390⟩
Journal articles hal-02197268v1

The Chromosome 21 Kinase DYRK1A and Its Substrate FOXO1 Constitute a Novel Therapeutic Pathway in B-ALL

Rahul Bhansali , Malini Rammohan , Ji Heon Paul Lee , Sebastien Malinge , Yi-Chien Tsai
Blood, 2018, 132 (S1), pp.548-548. ⟨10.1182/blood-2018-99-119854⟩
Journal articles hal-02384966v1
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Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

Florence Couly , Marine Harari , Carole Dubouilh-Benard , Laëtitia Bailly , Emilie Petit
Molecules, 2018, 23 (9), pp.2181. ⟨10.3390/molecules23092181⟩
Journal articles hal-02024491v1

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

T.L. Nguyen , Corinne Fruit , Y. Hérault , L. Meijer , Thierry Besson
Expert Opinion on Therapeutic Patents, 2017, 27 (11), pp.1183-1199. ⟨10.1080/13543776.2017.1360285⟩
Journal articles hal-02046302v1

Late-Stage C-H Arylation of Thiazolo[5,4- f ]quinazolin-9(8 H)-one Backbone: Synthesis of an Array of Potential Kinase Inhibitors

Florence Couly , Carole Dubouilh-Benard , Thierry Besson , Corinne Fruit
Synthesis: Journal of Synthetic Organic Chemistry, 2017, 49 (20), pp.4615-4622. ⟨10.1055/s-0036-1588434⟩
Journal articles hal-02046272v1

Pd-Catalyzed and Copper Assisted Regioselective Sequential C2 and C7 Arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one with Aryl Halides

Marine Harari , Florence Couly , Corinne Fruit , Thierry Besson
Organic Letters, 2016, 18 (13), pp.3282-3285. ⟨10.1021/acs.orglett.6b01552⟩
Journal articles hal-02046211v1

An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases

A. Chaikuad , J. Diharce , M. Schröder , Alicia Foucourt , B. Leblond
Journal of Medicinal Chemistry, 2016, 59 (22), pp.10315-10321. ⟨10.1021/acs.jmedchem.6b01083⟩
Journal articles hal-02046195v1
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Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

Damien Hédou , Julien Godeau , N. Loaëc , L. Meijer , Corinne Fruit
Molecules, 2016, 21 (5), pp.578. ⟨10.3390/molecules21050578⟩
Journal articles hal-02046213v1
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Synthesis of bioactive 2-(arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff reaction or Cu- catalyzed intramolecular C-S bond formation

Damien Hédou , Carole Dubouilh-Benard , N. Loaëc , L. Meijer , Corinne Fruit
Molecules, 2016, 21 (6), pp.794. ⟨10.3390/molecules21060794⟩
Journal articles hal-02046212v1

Efficient Microwave-Assisted Synthesis of Methyl 4- or 5-Nitro­anthranilate

Julien Godeau , Anthony Martinet , Vincent Levacher , Corinne Fruit , Thierry Besson
Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (20), pp.3504-3508. ⟨10.1055/s-0035-1562484⟩
Journal articles hal-02046207v1

Recent Developments in Microwave-Assisted Metal-Catalyzed C-H Functionalization of Heteroarenes for Medicinal Chemistry and Material Applications

Thierry Besson , Corinne Fruit
Synthesis: Journal of Synthetic Organic Chemistry, 2016, 48 (22), pp.3879-3889. ⟨10.1055/s-0035-1562608⟩
Journal articles hal-02046186v1

A novel DYRK1A (Dual specificity tyrosine phosphorylation‐regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro

S. Coutadeur , H. Benyamine , L. Delalonde , C. de Oliveira , B. Leblond
Journal of Neurochemistry, 2015, 133 (3), pp.440-451. ⟨10.1111/jnc.13018⟩
Journal articles hal-02046148v1

Ligand-Free Pd-Catalyzed and Copper-Assisted C−H Arylation ofQuinazolin-4-ones with Aryl Iodides under Microwave Heating

Sylvain Laclef , Marine Harari , Julien Godeau , Isabelle Schmitz-Afonso , Laurent Bischoff
Organic Letters, 2015, organic letters, 17 (7), pp.1700-1713. ⟨10.1021/acs.orglett.5b00467⟩
Journal articles hal-01141150v1

Synthesis of polyfunctionalized benzo[d]thiazoles as novel anthranilic acid derivatives

Damien Hédou , Marine Harari , Julien Godeau , Carole Dubouilh-Benard , Corinne Fruit
Tetrahedron Letters, 2015, 56 (27), pp.4088-4092. ⟨10.1016/j.tetlet.2015.05.018⟩
Journal articles hal-01160622v1

Cu/Pd-catalyzed C-2-H arylation of quinazolin-4(3H)-ones with (hetero)aryl halides

Julien Godeau , Marine Harari , Sylvain Laclef , Emmanuel Deau , Corinne Fruit
European Journal of Organic Chemistry, 2015, 2015 (35), pp.7705-7717. ⟨10.1002/ejoc.201501129⟩
Journal articles hal-02046152v1
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DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

B. J. Thompson , R. Bhansali , L. Diebold , D. E. Cook , L. Stolzenburg
Journal of Experimental Medicine, 2015, 212 (6), pp.723-740. ⟨10.1084/jem.20150002⟩
Journal articles hal-01160621v1

Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors

Yvonnick Loidreau , Emmanuel Deau , Pascal Marchand , Marie-Renée Nourrisson , Cédric Logé
European Journal of Medicinal Chemistry, 2015, 92, pp.124-134. ⟨10.1016/j.ejmech.2014.12.038⟩
Journal articles hal-01135195v1

Microwave-assisted synthesis of novel N-(4-phenylthiazol-2-yl)-benzo[d]thiazole-, thiazolo[4,5-b]pyridine-, thiazolo[5,4-b]pyridine- and benzo[d]oxazole-2-carboximidamides inspired by marine topsentines and nortopsentines

Emmanuel Deau , Carole Dubouilh-Benard , Vincent Levacher , Thierry Besson
Tetrahedron, 2014, 70 (35), pp.5532-5540. ⟨10.1016/j.tet.2014.06.102⟩
Journal articles hal-01141178v1
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Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II

Alicia Foucourt , Damien Hédou , Carole Dubouilh-Benard , Angelique Girard , Thierry Taverne
Molecules, 2014, 19 (10), pp.15411-15439. ⟨10.3390/molecules191015411⟩
Journal articles hal-01135223v1

Rational multistep synthesis of a novel polyfunctionalized benzo[d]thiazole and its thiazolo[5,4-b]pyridine analogue

Damien Hédou , Emmanuel Deau , Marine Harari , Morgane Sanselme , Corinne Fruit
Tetrahedron, 2014, 70 (5541-5549), pp.5541-5549. ⟨10.1016/j.tet.2014.06.103⟩
Journal articles hal-01141181v1
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Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

Alicia Foucourt , Damien Hédou , Carole Dubouilh-Benard , Laurent Désiré , Anne-Sophie Casagrande
Molecules, 2014, 19 (10), pp.15546-15571. ⟨10.3390/molecules191015546⟩
Journal articles hal-01141172v1

Efficient new synthesis of N-arylbenzo[b]furo[3,2-d]pyrimidin-4-amines and their benzo[b]thieno[3,2-d]pyrimidin-4-amine analogues via a microwave-assisted Dimroth rearrangement

Yvonnick Loidreau , Carole Dubouilh-Benard , Pascal Marchand , Marie-Renée Nourrisson , Muriel Duflos
Journal of Heterocyclic Chemistry, 2013, 50 (5), pp.1187-1197. ⟨10.1002/jhet.1716⟩
Journal articles hal-01015485v1

Microwave-Assisted [3+2] Cycloaddition and Suzuki-Miyaura Cross-Coupling for a Concise Access to Polyaromatic Scaffolds

Damien Hédou , Emmanuel Deau , Carole Dubouilh-Benard , Morgane Sanselme , Anthony Martinet
European Journal of Organic Chemistry, 2013, 2013 (33), pp.7533-7545. ⟨10.1002/ejoc.201301014⟩
Journal articles hal-01015445v1

Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole

Rémi Guillon , Fabrice Pagniez , Carine Picot , Damien Hédou , Alain Tonnerre
ACS Medicinal Chemistry Letters, 2013, 4 (2), pp.288-292. ⟨10.1021/ml300429p⟩
Journal articles hal-01015468v1

Convenient one-pot synthesis of N3-substituted pyrido[2,3-d]-, pyrido[3,4-d]-, pyrido[4,3-d]-pyrimidin-4(3H)-ones, and quinazolin-4(3H)-ones analogs

Emmanuel Deau , Damien Hédou , Elizabeth Chosson , Vincent Levacher , Thierry Besson
Tetrahedron Letters, 2013, 54 (27), pp.3518-3521. ⟨10.1016/j.tetlet.2013.04.096⟩
Journal articles hal-01015451v1

Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.

Svetlana Postikova , Mohamad Sabbah , Daniel Wightman , Ich Tuan Nguyen , Morgane Sanselme
Journal of Organic Chemistry, 2013, 78 (16), pp.8191-8197. ⟨10.1021/jo401259w⟩
Journal articles hal-00997427v1

Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.

Emmanuel Deau , Yvonnick Loidreau , Pascal Marchand , Marie-Renée Nourrisson , Nadège Loaëc
Bioorganic and Medicinal Chemistry Letters, 2013, 23 (24), pp.6784-6788. ⟨10.1016/j.bmcl.2013.10.019⟩
Journal articles hal-00997420v1

Novel synthesis of angular thiazolo[5,4-f] and [4,5-h]quinazolines, preparation of their linear thiazolo[4,5-g] and [5,4-g]quinazoline analogs

Damien Hédou , Rémi Guillon , Charlotte Lecointe , Cédric Logé , Elizabeth Chosson
Tetrahedron, 2013, 69 (15), pp.3182-3191. ⟨10.1016/j.tet.2013.02.066⟩
Journal articles hal-01015586v1

Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.

Yvonnick Loidreau , Pascal Marchand , Carole Dubouilh-Benard , Marie-Renée Nourrisson , Muriel Duflos
European Journal of Medicinal Chemistry, 2013, 59, pp.283-295. ⟨10.1016/j.ejmech.2012.11.030⟩
Journal articles hal-00997416v1

Suzuki cross-coupling of 5-bromothieno[2,3-b]pyridines for the convenient synthesis of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines

Yvonnick Loidreau , Vincent Levacher , Thierry Besson
Tetrahedron Letters, 2013, 54 (9), pp.1160-1163. ⟨10.1016/j.tetlet.2012.12.077⟩
Journal articles hal-01015472v1

Study of N1-alkylation of indoles from the reaction of 2(or 3)-aminoindole-3-(or 2)carbonitriles with DMF-dialkylacetals

Yvonnick Loidreau , Sigismund Melissen , Vincent Levacher , Cédric Logé , Jérôme Graton
Organic & Biomolecular Chemistry, 2012, 10 (25), pp.4916-4925. ⟨10.1039/c2ob25747e⟩
Journal articles hal-00997070v1

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

Elizabeth Chosson , Francesca Santoro , Christophe Rochais , Jana Sopkova-de Oliveira Santos , Rémi Legay
Bioorganic and Medicinal Chemistry Letters, 2012, 20 (8), pp.2614-2623. ⟨10.1016/j.bmc.2012.02.043⟩
Journal articles hal-02357753v1

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors

Yvonnick Loidreau , Pascal Marchand , Carole Dubouilh-Benard , Marie-Renée Nourrisson , Muriel Duflos
European Journal of Medicinal Chemistry, 2012, 58, pp.171-183. ⟨10.1016/j.ejmech.2012.10.006⟩
Journal articles hal-02357785v1

First synthesis of 4-aminopyrido[2′,3′:4,5]furo[3,2-d]pyrimidines

Yvonnick Loidreau , Pascal Marchand , Carole Dubouilh-Benard , Marie-Renée Nourrisson , Muriel Duflos
Tetrahedron Letters, 2012, 53 (8), pp.944-947. ⟨10.1016/j.tetlet.2011.12.042⟩
Journal articles hal-01016753v1

Microwave-assisted thermal decomposition of formamide: a tool for coupling a pyrimidine ring with an aromatic partner

Yvonnick Loidreau , Thierry Besson
Tetrahedron, 2011, 67 (26), pp.4852-4857. ⟨10.1016/j.tet.2011.05.010⟩
Journal articles hal-01018135v1
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Structure of Pb2+/dCMP and Pb2+/CMP complexes as characterized by tandem mass spectrometry and IRMPD spectroscopy

Jean-Yves Salpin , Létitia Gamiette , Jeanine Tortajada , Thierry Besson , Philippe Maître
International Journal of Mass Spectrometry, 2011, 304 (2-3), pp.154-164. ⟨10.1016/j.ijms.2010.07.011⟩
Journal articles hal-00619188v1

Binaphthyl platform as starting materials for the preparation of electron rich benzo[g,h,i]perylenes. Application to molecular architectures based on amino benzo[g,h,i]perylenes and carborane combinations.

Grégory Pieters , Anne Gaucher , Damien Prim , Thierry Besson , José Giner Planas
Chemical Communications, 2011, 47 (27), pp.7725-7727. ⟨10.1039/c1cc12099a⟩
Journal articles hal-01018301v1

Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent.

Alicia Foucourt , Carole Dubouilh-Benard , Elizabeth Chosson , Cecile Corbiere , Catherine Buquet
Tetrahedron, 2010, 66 (25), pp.4495-4502. ⟨10.1016/j.tet.2010.04.066⟩
Journal articles hal-01020796v1

Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells.

Ruben F Tchokouaha , Xanthippi Alexi , Elizabeth Chosson , Thierry Besson , Alexios-Leandros Skaltsounis
Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 25 (2), pp.228-233. ⟨10.3109/14756360903169972⟩
Journal articles hal-01020552v1

First synthesis of 2-aminosubstituted-2-perfluoroalkyl-3,6-dihydro-2H-thiopyrans by hetero-Diels-Alder reactions of fluorinated thioamides under microwave heating

Sergey S Mikhailichenko , J.-P. Bouillon , Thierry Besson , Yuryi G Shermolovich
Tetrahedron Letters, 2010, 51 (6), pp.990-993. ⟨10.1016/j.tetlet.2009.12.064⟩
Journal articles hal-01019603v1

Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives

Anne Beauchard , Alexis Jaunet , Laurence Murillo , Brigitte Baldeyrou , Amélie Lansiaux
European Journal of Medicinal Chemistry, 2009, 44 (10), pp.3858-3865. ⟨10.1016/j.ejmech.2009.04.012⟩
Journal articles hal-01449310v1

Synthesis and kinase inhibitory activity of novel substituted indigoids

Anne Beauchard , Helene Laborie , Hervé Rouillard , Olivier Lozach , Yoan Ferandin
Bioorganic and Medicinal Chemistry Letters, 2009, 17 (17), pp.6257-6263. ⟨10.1016/j.bmc.2009.07.051⟩
Journal articles hal-02357759v1

Microwave-assisted synthesis of alpha-ethoxycarbamates

Alexandre Lumbroso , Floris Chevallier , Isabelle Beaudet , Jean-Paul Quintard , Thierry Besson
Tetrahedron, 2009, 65 (45), pp.9180-9187. ⟨10.1016/j.tet.2009.09.023⟩
Journal articles hal-02143508v1

Synthesis and kinase inhibitory activity of novel substituted indigoids.

Anne Beauchard , Hélène Laborie , Hervé Rouillard , Olivier Lozach , Yoan Ferandin
Bioorganic and Medicinal Chemistry, 2009, 17 (17), pp.6257-63. ⟨10.1016/j.bmc.2009.07.051⟩
Journal articles hal-00416031v1
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Tautomerism of uracil probed via IR spectroscopy of singly hydrated uracil.

Joost M. Bakker , Thierry Besson , Maurizio Brugnara , Paolo Tosi , Jean-Yves Salpin
Journal of Physical Chemistry A, 2008, 112 (48), pp.12393-12400. ⟨10.1021/jp806396t⟩
Journal articles hal-00368127v1

Microwave-assisted Synthesis of Novel Thiazolocarbazoles and Evaluation as Potential Anticancer Agents. Part III

Alexandra Testard , Laurent Picot , Ingrid Fruitier-Arnaudin , Jean-Marie Piot , Hadjila Chabane
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 19 (6), pp.467-473. ⟨10.1080/14756360412331280491⟩
Journal articles hal-01967795v1

Structure of electron-capture dissociation fragments from charge-tagged peptides probed by tunable infrared multiple photon dissociation.

Gilles Frison , Guillaume van Der Rest , Frantisek Turecek , Thierry Besson , Joël Lemaire
Journal of the American Chemical Society, 2008, 130 (45), pp.14916-14917. ⟨10.1021/ja805257v⟩
Journal articles hal-00467063v1

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies

Cédric Logé , Alexandra Testard , Valérie Thiéry , Olivier Lozach , Mélina Blairvacq
European Journal of Medicinal Chemistry, 2008, 43 (7), pp.1469-1477. ⟨10.1016/j.ejmech.2007.09.020⟩
Journal articles hal-02357774v1

Synthesis and evaluation of the antimicrobial activity of novel quinazolinones

Maria de Fatima Pereira , Romain Chevrot , Eric Rosenfeld , Valérie Thiéry , Thierry Besson
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 22 (5), pp.577-583. ⟨10.1080/14756360701425345⟩
Journal articles hal-01960717v1

Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres

François Liger , Florence Popowycz , Thierry Besson , Laurent Picot , Carlos Galmarini
Bioorganic and Medicinal Chemistry Letters, 2007, 15 (16), pp.5615-5619. ⟨10.1016/j.bmc.2007.05.033⟩
Journal articles hal-02357763v1

On the origin of some cubebene derivatives — Diels–Alder adducts and the diene structures of solidago compounds

Christopher Jankowski , André Pelletier , Eduardo Diaz T. , Jacqueline M.R Belanger , Jocelyn J.R Paré
Canadian Journal of Chemistry, 2007, 85 (11), pp.996-1005. ⟨10.1139/V07-112⟩
Journal articles hal-02357729v1

Synthesis of latonduine derivatives via intramolecular Heck coupling reaction

A. Putey , L. Joucla , L. Picot , Thierry Besson , B. Joseph.
Tetrahedron, 2007, pp.63, 867
Journal articles hal-00158714v1

Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3

Alexandra Testard , Cédric Logé , Benoît Léger , Jean-Michel Robert , Olivier Lozach
Bioorganic and Medicinal Chemistry Letters, 2006, 16 (13), pp.3419-3423. ⟨10.1016/j.bmcl.2006.04.006⟩
Journal articles hal-02357746v1

Synthesis of novel 2,3-condensed thieno[2,3- d ]pyrimidin-4-ones via Appel's salt chemistry

Maria de Fatima Pereira , Valérie Thiéry , Thierry Besson
Journal of Sulfur Chemistry, 2006, 27 (1), pp.49-55. ⟨10.1080/17415990500493213⟩
Journal articles hal-02357738v1

Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Anne Beauchard , Yoan Ferandin , Stéphane Frère , Olivier Lozach , Mélina Blairvacq
Bioorganic and Medicinal Chemistry, 2006, 14 (18), pp.6434-43. ⟨10.1016/j.bmc.2006.05.036⟩
Journal articles hal-00169371v1

Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.

Alexandra Testard , Laurent Picot , Olivier Lozach , Melina Blairvacq , Laurent Meijer
Journal of Enzyme Inhibition and Medicinal Chemistry, 2005, 20 (6), pp.557-568. ⟨10.1080/14756360500212399⟩
Journal articles hal-01443570v1

Eco-Friendly Microwave-Assisted Scaleable Synthesis of 2-Cyanobenzothiazoles via N -Arylimino-1,2,3-dithiazoles

Stéphane Frère , Valérie Thiéry , Thierry Besson
Synthetic Communications, 2003, 33 (21), pp.3795-3804. ⟨10.1081/SCC-120025190⟩
Journal articles hal-02357713v1

Eco-Friendly Microwave-Assisted Scaleable Synthesis of 2-Cyanobenzothiazoles via N -Arylimino-1,2,3-dithiazoles

Valérie Thiéry , Thierry Besson
Synthetic Communications, 2003, 33 (21), pp.3795-3804. ⟨10.1081/SCC-120025190⟩
Journal articles hal-02357727v1

Efficient solvent-free microwave phosphorylation of microcrystalline cellulose

Natalia Gospodinova , Axelle Grelard , Marc Jeannin , Gabrielle Chitanu , Adrian Carpov
Green Chemistry, 2002, 4 (3), pp.220-222. ⟨10.1039/b200295g⟩
Journal articles hal-02357733v1

Rapid synthesis of 2-cyanobenzothiazole, isothiocyanate and cyanoformanilide derivatives of dapsone †

Thierry Besson , Jérôme Guillard , Charles Rees
Journal of the Chemical Society, Perkin Transactions 1, 2000, 4, pp.563-566. ⟨10.1039/a908742g⟩
Journal articles hal-02357789v1

Imidazoquinolinethiones from 8-aminoquinolines by a novel peri-participation

Thierry Besson , Charles Rees , David Roe , Valérie Thiéry
Journal of the Chemical Society, Perkin Transactions 1, 2000, 4, pp.555-561. ⟨10.1039/a908952g⟩
Journal articles hal-02357793v1

Fe and H2O2 distributions in the upper water column in the Indian sector of the Southern Ocean

Géraldine Sarthou , C. Jeandel , Laurence Brisset , David Amouroux , Thierry Besson
Earth and Planetary Science Letters, 1998, 147 (1-4), pp.83-92. ⟨10.1016/S0012-821X(97)00004-6⟩
Journal articles hal-00456475v1

N-(Cyanothioformyl)indoline; a new indoline ring forming reaction

Thierry Besson , Gerald Guillaumet , Christelle Lamazzi , Charles Rees , Valérie Thiéry
Journal of the Chemical Society, Perkin Transactions 1, 1998
Journal articles hal-02357800v1

Rapid Synthesis of 2-Cyanobenzothiazoles from N -Aryliminodithiazoles Under Microwave Irradiation

Valérie Bénéteau , Thierry Besson , Charles Rees
Synthetic Communications, 1997, 27 (13), pp.2275-2280. ⟨10.1080/00397919708003382⟩
Journal articles hal-02357709v1

3,1-Benzoxazin-4-ones, 3,1-benzothiazin-4-ones and N-arylcyanothioformamides

Thierry Besson , Kumaraswamy Emayan , Charles Rees
Journal of the Chemical Society, Chemical Communications, 1995, 14, pp.1419. ⟨10.1039/C39950001419⟩
Journal articles hal-02357768v1

Synthesis of a benzodioxinic analog of 8-methoxypsoralen

Thierry Besson , Nicolas Ruiz , Gérard Coudert , Gerald Guillaumet
Tetrahedron, 1995, 51 (11), pp.3197-3204. ⟨10.1016/0040-4020(95)00058-G⟩
Journal articles hal-02889857v1

Biophysical and biological properties of newly synthesized dioxinocoumarin derivatives

Gabriella Csík , Györgyi Rontó , Silvano Nocentini , Simone Averbeck , Dietrich Averbeck
Journal of Photochemistry and Photobiology B: Biology, 1994, 24 (2), pp.129-139. ⟨10.1016/1011-1344(94)07015-6⟩
Journal articles hal-02889856v1

Convenient synthesis of 5-substituted-6-methoxy or 6-hydroxy-2,3-dihydro-1,4-benzodioxins via lithiated intermediates

Thierry Besson , Mohamed Hretani , Gérard Coudert , Gerald Guillaumet
Tetrahedron, 1993, 49 (7), pp.1421-1430. ⟨10.1016/S0040-4020(01)90194-2⟩
Journal articles hal-02889858v1

A mild One-Step Procedure for the Synthesis of β-Iodo Epoxides from the Corresponding Epoxy-Alcohols

Thierry Besson , Patrick Rollin
Synthetic Communications, 1990, 20 (19), pp.3039-3044. ⟨10.1080/00397919008051523⟩
Journal articles hal-02357707v1

Mitsunobu Thiofunctionalization-Part 2. 1 an Expedient Synthesis of Aza-Heterocycle/Thiosugar Hybrids

Thierry Besson , Mamdouh Al Neirabeyeh , Marie-Claude Viaud , Patrick Rollin
Synthetic Communications, 1990, 20 (11), pp.1631-1639. ⟨10.1080/00397919008053083⟩
Journal articles hal-02357706v1

Conception et synthèses d'inhibiteurs de la kinase DYRK1A

Thierry Besson
Séminaire national, Faculté de pharmacie de l'Université de Tours, Jun 2018, Tours, France
Conference papers hal-02391097v1

Promising DYRK1A inhibitor synthesized by late-stage C-H Arylation

Florence Couly , Corinne Fruit , Thierry Besson
Journées franco-belges de chimie thérapeutique (JFB, 32, 2018) - Conférences européennes des pharmacochimistes de l'Arc Atlantique (GP2A, 26, 2018), Jun 2018, Asnelles-sur-Mer, France
Conference papers hal-02384759v1

Conception of DYRK1A kinase inhibitors via metal-catalyzed C-H arylation, inspired by fragment-growing studies

Florence Couly , Julien Diharce , Pascal Bonnet , Meijer Laurent , Corinne Fruit
International Electronic Conference on Medicinal Chemistry (ECMC, 4, 2018), Jean-Jacques Vanden Eynde (coord.), Nov 2018, [online], Belgium. ⟨10.3390/ecmc-4-05580⟩
Conference papers hal-02383907v1

Design and synthesis of DYRK's family kinases inhibitors against neurodegenerative diseases

Thierry Besson
Séminaire international, Katholieke Universiteit Leuven (KU), Jun 2017, Louvain, Belgium
Conference papers hal-02390455v1

Design and synthesis of DYRK's family kinases inhibitors against neurodegenerative diseases

Thierry Besson
Séminaire international, Universiteit Gent, Jun 2017, Gand, Belgium
Conference papers hal-02390460v1

Late-stage C-H Arylation of Thiazolo[5,4-f]quinazolin-9(8H)-one Backbone: Synthesis of an Array of Potential Kinase Inhibitors

Florence Couly , Carole Dubouilh-Benard , Meijer Laurent , Corinne Fruit , Thierry Besson
International Electronic Conference on Medicinal Chemistry (ECMC, 3, 2017), Jean-Jacques Vanden Eynde, Nov 2017, [online], Belgium. ⟨10.3390/ecmc-3-04650⟩
Conference papers hal-02383887v1

Synthesis of Bioactive 2-(arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation

Damien Hédou , Carole Dubouilh-Benard , Nadège Loaëc , Meijer Laurent , Corinne Fruit
International Electronic Conference on Medicinal Chemistry (ECMC, 2, 2016), Jean-Jacques Vanden Eynde (coord.), Nov 2016, [online], Belgium. ⟨10.3390/ecmc-2-A010⟩
Conference papers hal-02383867v1

Late-Stage Sequential C-H Functionalization of Thiazolo[5,4-f]quina-zolin-9(8H)-one: Synthesis of a Library of Potential Kinase Inhibitors

Corinne Fruit , Florence Couly , Marine Harari , Vincent Levacher , Thierry Besson
International Electronic Conference on Synthetic Organic Chemistry (ECSOC, 20, 2016), Julio A. Seijas Vázquez (coord.), Nov 2016, [online], Spain
Conference papers hal-02383920v1

Thiazolo[5,4-f]quinazolines as DYRK Kinases inhibitors

Thierry Besson
Journées franco-belges de pharmacochimie (JFB, 30, 2016), May 2016, Amboise, France
Conference papers hal-02379426v1

Kinase inhibitors and microwave-assisted chemistry, a nice story

Thierry Besson
Séminaire national, Université de Versailles Saint-Quentin (UVSQ), Sep 2015, Amiens, France
Conference papers hal-02390779v1

Microwave-assisted C-H arylation of Quinazolin-4-one-type Precursors of Bioactive Heterocycles

Corinne Fruit , Julien Godeau , Marine Harari , Vincent Levacher , Thierry Besson
International Electronic Conference on Medicinal Chemistry (ECMC, 1, 2015), Jean-Jacques Vanden Eynde (coord.), Nov 2015, [online], Belgium. ⟨10.3390/ecmc-1-A004⟩
Conference papers hal-02383839v1

Kinase inhibitors and microwave-assisted chemistry, a nice story

Thierry Besson
Séminaire national, Université de Picardie Jules Verne (UPJV), Jun 2015, Amiens, France
Conference papers hal-02390509v1

Ligand-free Pd/Cu-catalyzed microwave-assisted C-H arylation of quinazolin-4(3H)-ones with aryl iodides

Marine Harari , Corinne Fruit , Thierry Besson
Semaine d'études en chimie organique (SECO, 52, 2015), May 2015, Morzine, France
Conference papers hal-02378695v1

Microwave extraction of bioactive molecules

E. Destandau , S. Zubrzycki , C. Elfakir , Abdelhakim Elomri , Thierry Besson
Cosmetic innovation days (COSMINNOV, 2013), Oct 2013, Orléans, France
Conference papers hal-02550339v1

IRMPD spectroscopy and quantum chemistry: two ideal partners for probing the structure of gaseous ions

Jean-Yves Salpin , Edith Nicol , Thierry Besson , William Buchmann , Marie-Pierre Gaigeot
35th congress of theoretical chemists of latin expression 35th QUITEL, Sep 2009, San Andres, Colombia
Conference papers hal-00514248v1

Interaction of Pb2+ ions with nucleic acids building blocks: tandem mass spectrometry and IRMPD spectroscopy

Jean-Yves Salpin , Jeanine Tortajada , Thierry Besson , Joel Lemaire , Debora Scuderi
Isolated Biomolecules and Biomolecular interactions, Apr 2008, Valladolid, Spain
Conference papers hal-00275019v1