Thomas Secher

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Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes

Lola Bosc , Thomas Sécher , Genevieve Ball , Deborah Le Pennec , Mathilde Tribout et al.

Infection and Immunity, 2026, 94 (2), pp.e00453-25. ⟨10.1128/iai.00453-25⟩

Article dans une revue hal-05458347v1
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Exploring airway biological barriers: Implications for IgG-based therapeutics in respiratory infections

Gabrielle Pichon , Christelle Parent , Stefanie Graeter , Alexander Schaub , Anna Schnell et al.

European Journal of Pharmaceutics and Biopharmaceutics, 2025, 215, pp.114817. ⟨10.1016/j.ejpb.2025.114817⟩

Article dans une revue hal-05241299v1
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A breath of fresh air: inhaled antibodies to combat respiratory infectious diseases - a clinical trial overview

Noémie Alphonse , Thomas Secher , Nathalie Heuzé-Vourc’h

Expert Opinion on Drug Delivery, 2025, 22 (2), pp.197-218. ⟨10.1080/17425247.2024.2446608⟩

Article dans une revue hal-04976146v1
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Synergy between Lactobacillus murinus and anti-PcrV antibody delivered in the airways to boost protection against Pseudomonas aeruginosa

Thomas Secher , Mélanie Cortes , Chloé Boisseau , Marie-Thérèse Barba Goudiaby , Aubin Pitiot et al.

Molecular Therapy - Methods and Clinical Development, 2024, 32 (4), pp.101330. ⟨10.1016/j.omtm.2024.101330⟩

Article dans une revue hal-04834283v1

The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies

Timothée Blin , Christelle Parent , Gabrielle Pichon , Antoine Guillon , Youenn Jouan et al.

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 195, pp.114163. ⟨10.1016/j.ejpb.2023.12.003⟩

Article dans une revue hal-04484465v1

The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies

Timothée Blin , Christelle Parent , Gabrielle Pichon , Antoine Guillon , Youenn Jouan et al.

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 195, pp.114163. ⟨10.1016/j.ejpb.2023.12.003⟩

Article dans une revue hal-05500313v1

Barriers for orally inhaled therapeutic antibodies

Thomas Secher , Nathalie Heuzé-Vourc’h

Expert Opinion on Drug Delivery, 2023, 20 (8), pp.1071-1084. ⟨10.1080/17425247.2023.2249821⟩

Article dans une revue hal-04834313v1
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Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

Thomas Sécher , Elsa Bodier-Montagutelli , Christelle Parent , Laura Bouvart , Mélanie Cortes et al.

Pharmaceutics, 2022, 14 (3), pp.671. ⟨10.3390/pharmaceutics14030671⟩

Article dans une revue hal-03687448v1
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Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives

Alexie Mayor , Adélaïde Chesnay , Guillaume Desoubeaux , David Ternant , Nathalie Heuzé-Vourc'H et al.

Vaccines, 2021, 9 (2), pp.151. ⟨10.3390/vaccines9020151⟩

Article dans une revue hal-03485350v1
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Immune Checkpoint and Anti-Angiogenic Antibodies for the Treatment of Non-Small Cell Lung Cancer in the European Union and United States

Marion Ferreira , Thomas Secher , Nathalie Heuzé-Vourc'H , Karen Reckamp

Pharmaceutics, 2021, 13 (6), pp.912. ⟨10.3390/pharmaceutics13060912⟩

Article dans une revue hal-03382451v1
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Therapeutic antibodies – natural and pathological barriers and strategies to overcome them

Yara Al Ojaimi , Timothée Blin , Juliette Lamamy , Matthieu Gracia , Aubin Pitiot et al.

Pharmacology & Therapeutics, 2021, pp.108022. ⟨10.1016/j.pharmthera.2021.108022⟩

Article dans une revue hal-03531953v1
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Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo et al.

ImmunoHorizons , 2021, 5 (5), pp.273-283. ⟨10.4049/immunohorizons.2000095⟩

Article dans une revue hal-03258180v1
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MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands

Marion Pavlovic , Christelle Gross , Chahinaize Chili , Thomas Secher , Emmanuel Treiner

Frontiers in Immunology, 2020, 11 (article 2097), pp.1-16. ⟨10.3389/fimmu.2020.02097⟩

Article dans une revue hal-03154944v1

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure

Nadine Waldschmitt , Sho Kitamoto , Thomas Secher , Vassiliki Zacharioudaki , Olivier Boulard et al.

Gut, 2019, 68 (7), pp.1190-1199. ⟨10.1136/gutjnl-2018-316757⟩

Article dans une revue hal-02126570v1
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Inhalation of Immuno-Therapeutics/- Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place!

Thomas Secher , Alexie Mayor , Nathalie Heuzé-Vourc'H

Frontiers in Immunology, 2019, 1, ⟨10.3389/fimmu.2019.02760⟩

Article dans une revue hal-02439828v1
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Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917

Clémence Massip , Priscilla Branchu , Nadège Bossuet-Greif , Camille V Chagneau , Déborah Gaillard et al.

PLoS Pathogens, 2019, 15 (9), pp.e1008029. ⟨10.1371/journal.ppat.1008029⟩

Article dans une revue inserm-02320208v1
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In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration

Thomas Secher , Emilie Dalonneau , Marion Ferreira , Christelle Parent , Nicolas Azzopardi et al.

Journal of Controlled Release, 2019, 303, pp.24-33. ⟨10.1016/j.jconrel.2019.04.005⟩

Article dans une revue hal-02179896v1
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The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice

Thomas Secher , Isabelle Maillet , Claire Mackowiak , Jessica Le Bérichel , Amandine Philippeau et al.

Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29689-9⟩

Article dans une revue hal-02126575v1

Therapeutic antibodies: A new era in the treatment of respiratory diseases?

Thomas Secher , L. Guilleminault , K. Reckamp , I. Amanam , L. Plantier et al.

Pharmacology & Therapeutics, 2018, 189, pp.149-172. ⟨10.1016/j.pharmthera.2018.05.003⟩

Article dans une revue istex hal-02439820v1
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Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics

A. Guillon , Thomas Secher , L.A. Dailey , L. Vecellio , M. de Monte et al.

International Journal of Pharmaceutics, 2018, 536 (1), pp.116-126. ⟨10.1016/j.ijpharm.2017.11.049⟩

Article dans une revue hal-02439838v1
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The food contaminant deoxynivalenol exacerbates the genotoxicity of gut microbiota

Delphine Payros , Ulrich Dobrindt , Patricia Martin-Bizon , Thomas Secher , Ana-Paula Loureiro-Bracarense et al.

mBio, 2017, 8 (2), 11 p. ⟨10.1128/mBio.00007-17⟩

Article dans une revue hal-01608529v1

Mu and delta opioid receptor knockout mice show increased colonic sensitivity

David Reiss , Rhian Alice Ceredig , Thomas Secher , J. Boué , Frédérick Barreau et al.

European Journal of Pain, 2017, 21 (4), pp.623-634. ⟨10.1002/ejp.965⟩

Article dans une revue hal-01607491v1
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Oral Administration of the Probiotic Strain <em>Escherichia coli</em> Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction

Thomas Secher , Sahar Kassem , Mehdi Benamar , Isabelle Bernard-Cadenat , Michèle Boury et al.

Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.01096⟩

Article dans une revue hal-02624001v1
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DNA Inversion Regulates Outer Membrane Vesicle Production in B<em>acteroides fragilis</em>

Haruyuki Nakayama-Imaohji , Katsuhiko Hirota , Hisashi Yamasaki , Saori Yoneda , Hirofumi Nariya et al.

PLoS ONE, 2016, 11 (2), pp.1-21. ⟨10.1371/journal.pone.0148887⟩

Article dans une revue hal-02632202v1

Early settlers: which E. coli strains do you not want at birth?

Thomas Secher , Camille Brehin , Eric Oswald

AJP - Gastrointestinal and Liver Physiology, 2016, 311 (1), pp.G123 - G129. ⟨10.1152/ajpgi.00091.2016⟩

Article dans une revue hal-01602829v1
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Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

Thomas Secher , Delphine Payros , Camille Brehin , Michèle Boury , Claude Watrin et al.

Infection and Immunity, 2015, 83 (6), pp.2420-2429. ⟨10.1128/IAI.00064-15⟩

Article dans une revue hal-02634629v1

Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic <em>Escherichia coli</em>

Thomas Secher , Ayaka Shima , Karen Hinsinger , Jean Christophe Cintrat , Ludger Johannes et al.

Antimicrobial Agents and Chemotherapy, 2015, 59 (8), pp.5010-5013. ⟨10.1128/AAC.00455-15⟩

Article dans une revue hal-02640796v1
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IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice

Rodrigo Guabiraba , Anne-Gaëlle Besnard , Gustavo Batista Menezes , Thomas Secher , M. S. Jabir et al.

Mucosal Immunology, 2014, 7 (5), pp.1079-1093. ⟨10.1038/mi.2013.124⟩

Article dans une revue hal-02633989v1
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Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis

Delphine Payros , Thomas Secher , Michèle Boury , Camille Brehin , Sandrine Ménard et al.

Gut microbes, 2014, 5 (3), pp.313-325. ⟨10.4161/gmic.28932⟩

Article dans une revue hal-01859355v2

Dysbiosis, a new medical concept

Sylvain Normand , Thomas Secher , Mathias Chamaillard

Médecine/Sciences, 2013, 29 (6-7), pp.586-589. ⟨10.1051/medsci/2013296011⟩

Article dans une revue hal-02180092v1
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NOD2 prevents emergence of disease-predisposing microbiota

Thomas Secher , Sylvain Normand , Mathias Chamaillard

Gut microbes, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩

Article dans une revue hal-02180087v1

Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice

Bérengère Villeret , Lea Brault , Aurélie Couturier-Maillard , Pauline Robinet , Virginie Vasseur et al.

American journal of Clinical and Experimental Immunology, 2013, 2 (1), pp.107-116

Article dans une revue hal-02651056v1

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

Aurélie Couturier-Maillard , Thomas Secher , Ateequr Rehman , Sylvain Normand , Adèle de Arcangelis et al.

Journal of Clinical Investigation, 2013, 123 (2), pp.700-11. ⟨10.1172/JCI62236⟩

Article dans une revue hal-00944194v1
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<em>Escherichia coli</em> producing colibactin triggers premature and transmissible senescence in mammalian cells

Thomas Secher , Ascel Samba Louaka , Eric Oswald , Jean-Philippe Nougayrède

PLoS ONE, 2013, 8 (10), ⟨10.1371/journal.pone.0077157⟩

Article dans une revue hal-02646496v1
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Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

Maïwenn Olier , Ingrid Marcq , Christel Cartier , Thomas Secher , Ulrich Dobrindt et al.

Gut microbes, 2012, 3 (6), pp.501-509. ⟨10.4161/gutmicrobes.21737⟩

Article dans une revue hal-02935516v1

Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.

Kevin N Couper , Tom Barnes , Julius C R Hafalla , Valery Combes , Bernhard Ryffel et al.

PLoS Pathogens, 2010, 6 (1), pp.e1000744. ⟨10.1371/journal.ppat.1000744⟩

Article dans une revue hal-00591502v1

Remote control of intestinal tumorigenesis by innate immunity.

Thomas Secher , Olivier Gaillot , Bernhard Ryffel , Mathias Chamaillard

Cancer Research, 2010, 70 (5), pp.1749-52. ⟨10.1158/0008-5472.CAN-09-3401⟩

Article dans une revue hal-00591500v1

Local and remote tissue injury upon intestinal ischemia and reperfusion depends on the TLR/MyD88 signaling pathway.

Tatiana Victoni , Fernando Rodrigues Coelho , Alexandre Learth Soares , Andressa de Freitas , Thomas Secher et al.

Medical Microbiology and Immunology, 2010, 199 (1), pp.35-42. ⟨10.1007/s00430-009-0134-5⟩

Article dans une revue istex hal-00591521v1

IL-17 receptor signaling is required to control polymicrobial sepsis.

Andressa Freitas , José C Alves-Filho , Tatiana Victoni , Thomas Secher , Henrique P Lemos et al.

Journal of Immunology, 2009, 182 (12), pp.7846-54. ⟨10.4049/jimmunol.0803039⟩

Article dans une revue hal-00404905v1

Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis.

Thomas Secher , Virginie Vasseur , Didier Marc Poisson , Jane A Mitchell , Fernando Q Cunha et al.

Journal of Immunology, 2009, 182 (12), pp.7855-64. ⟨10.4049/jimmunol.0804008⟩

Article dans une revue hal-00404907v1

Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.

R. Dessein , M. Gironella , Clémentine Vignal , L. Peyrin-Biroulet , H. Sokol et al.

Gut, 2009, 58 (6), pp.771-6. ⟨10.1136/gut.2008.168443⟩

Article dans une revue istex hal-00404858v1
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Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.

Laure Janot , Jean-Claude Sirard , Thomas Secher , Nicolas Noulin , Lizette Fick et al.

European Journal of Immunology, 2009, 39 (6), pp.1587-96. ⟨10.1002/eji.200838907⟩

Article dans une revue inserm-00385299v1

CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection.

Laure Janot , Thomas Secher , David Torres , Isabelle Maillet , Josef Pfeilschifter et al.

Journal of Infectious Diseases, 2008, 198 (1), pp.115-24. ⟨10.1086/588815⟩

Article dans une revue hal-00318570v1

Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury.

Dieudonnée Togbe , Silvia Schnyder-Candrian , Bruno Schnyder , Emilie Doz , Nicolas Noulin et al.

International Journal of Experimental Pathology, 2007, 88 (6), pp.387-91. ⟨10.1111/j.1365-2613.2007.00566.x⟩

Article dans une revue hal-00318537v1

Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.

Jonathan Zalevsky , Thomas Secher , Sergei A Ezhevsky , Laure Janot , Paul M Steed et al.

Journal of Immunology, 2007, 179 (3), pp.1872-83

Article dans une revue hal-00318488v1

Mucosal administration of anti-bacterial antibody (Ab) provides long-term cross-protection against Pseudomonas aeruginosa respiratory infection

Aubin Pitiot , Marion Ferreira , Christelle Parent , Chloé Boisseau , Mélanie Cortes et al.

Journées d'Animation Scientifique de la FéRI 2022 - FéRi Scientific Days 2022, Fédération de Recherche en Infectiologie (FéRI), Centre Val de Loire, Jul 2022, Joué-Lès-Tours, France

Communication dans un congrès hal-03735460v1

A c-type lectin triggers immune surveillance by innate lymphoid cells for eradication of attaching-and-effacing bacteria

Bruno Lamas , Nadine Waldschmitt , Sho Kitamoto , Thomas Secher , Vassiliki Zacharioudaki et al.

25. United European Gastroenterology: Week, Oct 2017, Barcelone, Spain

Communication dans un congrès hal-02786603v1

Pulmonary Delivery of Antibody for the Treatment of Respiratory Diseases

Thomas Secher , Nathalie Heuzé-Vourc’h

Springer; AAPS. Respiratory Delivery of Biologics, Nucleic Acids, and Vaccines, 8, Springer International Publishing, pp.21-51, 2024, AAPS Introductions in the Pharmaceutical Sciences, ⟨10.1007/978-3-031-47567-2_2⟩

Chapitre d'ouvrage hal-04834340v1