Thomas Secher

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Publications

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A breath of fresh air: inhaled antibodies to combat respiratory infectious diseases - a clinical trial overview

Noémie Alphonse , Thomas Secher , Nathalie Heuzé-Vourc’h
Expert Opinion on Drug Delivery, 2025, 22 (2), pp.197-218. ⟨10.1080/17425247.2024.2446608⟩
Article dans une revue hal-04976146 v1
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Synergy between Lactobacillus murinus and anti-PcrV antibody delivered in the airways to boost protection against Pseudomonas aeruginosa

Thomas Secher , Mélanie Cortes , Chloé Boisseau , Marie-Thérèse Barba Goudiaby , Aubin Pitiot et al.
Molecular Therapy - Methods and Clinical Development, 2024, 32 (4), pp.101330. ⟨10.1016/j.omtm.2024.101330⟩
Article dans une revue hal-04834283 v1

The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies

Timothée Blin , Christelle Parent , Gabrielle Pichon , Antoine Guillon , Youenn Jouan et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2024, 195, pp.114163. ⟨10.1016/j.ejpb.2023.12.003⟩
Article dans une revue hal-04484465 v1

Barriers for orally inhaled therapeutic antibodies

Thomas Secher , Nathalie Heuzé-Vourc’h
Expert Opinion on Drug Delivery, 2023, 20 (8), pp.1071-1084. ⟨10.1080/17425247.2023.2249821⟩
Article dans une revue hal-04834313 v1
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Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

Thomas Sécher , Elsa Bodier-Montagutelli , Christelle Parent , Laura Bouvart , Mélanie Cortes et al.
Pharmaceutics, 2022, 14 (3), pp.671. ⟨10.3390/pharmaceutics14030671⟩
Article dans une revue hal-03687448 v1
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Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives

Alexie Mayor , Adélaïde Chesnay , Guillaume Desoubeaux , David Ternant , Nathalie Heuzé-Vourc'H et al.
Vaccines, 2021, 9 (2), pp.151. ⟨10.3390/vaccines9020151⟩
Article dans une revue hal-03485350 v1
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Immune Checkpoint and Anti-Angiogenic Antibodies for the Treatment of Non-Small Cell Lung Cancer in the European Union and United States

Marion Ferreira , Thomas Secher , Nathalie Heuzé-Vourc'H , Karen Reckamp
Pharmaceutics, 2021, 13 (6), pp.912. ⟨10.3390/pharmaceutics13060912⟩
Article dans une revue hal-03382451 v1
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Therapeutic antibodies – natural and pathological barriers and strategies to overcome them

Yara Al Ojaimi , Timothée Blin , Juliette Lamamy , Matthieu Gracia , Aubin Pitiot et al.
Pharmacology and Therapeutics, 2021, pp.108022. ⟨10.1016/j.pharmthera.2021.108022⟩
Article dans une revue hal-03531953 v1
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Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo et al.
ImmunoHorizons , 2021, 5 (5), pp.273-283. ⟨10.4049/immunohorizons.2000095⟩
Article dans une revue hal-03258180 v1
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Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo et al.
ImmunoHorizons , 2021, 5 (5), pp.273 - 283. ⟨10.4049/immunohorizons.2000095⟩
Article dans une revue hal-03429701 v1
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MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands

Marion Pavlovic , Christelle Gross , Chahinaize Chili , Thomas Secher , Emmanuel Treiner
Frontiers in Immunology, 2020, 11 (article 2097), pp.1-16. ⟨10.3389/fimmu.2020.02097⟩
Article dans une revue hal-03154944 v1
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Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917

Clémence Massip , Priscilla Branchu , Nadège Bossuet-Greif , Camille V Chagneau , Déborah Gaillard et al.
PLoS Pathogens, 2019, 15 (9), pp.e1008029. ⟨10.1371/journal.ppat.1008029⟩
Article dans une revue inserm-02320208 v1
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Inhalation of Immuno-Therapeutics/- Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place!

Thomas Secher , Alexie Mayor , Nathalie Heuzé-Vourc'H
Frontiers in Immunology, 2019, 1, ⟨10.3389/fimmu.2019.02760⟩
Article dans une revue hal-02439828 v1

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure

Nadine Waldschmitt , Sho Kitamoto , Thomas Secher , Vassiliki Zacharioudaki , Olivier Boulard et al.
Gut, 2019, 68 (7), pp.1190-1199. ⟨10.1136/gutjnl-2018-316757⟩
Article dans une revue hal-02126570 v1
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In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration

Thomas Secher , Emilie Dalonneau , Marion Ferreira , Christelle Parent , Nicolas Azzopardi et al.
Journal of Controlled Release, 2019, 303, pp.24-33. ⟨10.1016/j.jconrel.2019.04.005⟩
Article dans une revue hal-02179896 v1
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The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice

Thomas Secher , Isabelle Maillet , Claire Mackowiak , Jessica Le Bérichel , Amandine Philippeau et al.
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29689-9⟩
Article dans une revue hal-02126575 v1

Therapeutic antibodies: A new era in the treatment of respiratory diseases?

Thomas Secher , L. Guilleminault , K. Reckamp , I. Amanam , L. Plantier et al.
Pharmacology and Therapeutics, 2018, 189, pp.149-172. ⟨10.1016/j.pharmthera.2018.05.003⟩
Article dans une revue hal-02439820 v1
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Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics

A. Guillon , Thomas Secher , L.A. Dailey , L. Vecellio , M. de Monte et al.
International Journal of Pharmaceutics, 2018, 536 (1), pp.116-126. ⟨10.1016/j.ijpharm.2017.11.049⟩
Article dans une revue hal-02439838 v1
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The food contaminant deoxynivalenol exacerbates the genotoxicity of gut microbiota

Delphine Payros , Ulrich Dobrindt , Patricia Martin-Bizon , Thomas Secher , Ana-Paula Loureiro-Bracarense et al.
mBio, 2017, 8 (2), 11 p. ⟨10.1128/mBio.00007-17⟩
Article dans une revue hal-01608529 v1

Mu and delta opioid receptor knockout mice show increased colonic sensitivity

David Reiss , R.A. Ceredig , Thomas Secher , J. Boué , Frédérick Barreau et al.
European Journal of Pain, 2017, 21 (4), pp.623-634. ⟨10.1002/ejp.965⟩
Article dans une revue hal-01607491 v1
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Oral Administration of the Probiotic Strain <em>Escherichia coli</em> Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction

Thomas Secher , Sahar Kassem , Mehdi Benamar , Isabelle Bernard-Cadenat , Michèle Boury et al.
Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.01096⟩
Article dans une revue hal-02624001 v1
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DNA Inversion Regulates Outer Membrane Vesicle Production in B<em>acteroides fragilis</em>

Haruyuki Nakayama-Imaohji , Katsuhiko Hirota , Hisashi Yamasaki , Saori Yoneda , Hirofumi Nariya et al.
PLoS ONE, 2016, 11 (2), pp.1-21. ⟨10.1371/journal.pone.0148887⟩
Article dans une revue hal-02632202 v1

Early settlers: which E. coli strains do you not want at birth?

Thomas Secher , Camille Brehin , Eric Oswald
AJP - Gastrointestinal and Liver Physiology, 2016, 311 (1), pp.G123 - G129. ⟨10.1152/ajpgi.00091.2016⟩
Article dans une revue hal-01602829 v1
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Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

Thomas Secher , Delphine Payros , Camille Brehin , Michèle Boury , Claude Watrin et al.
Infection and Immunity, 2015, 83 (6), pp.2420-2429. ⟨10.1128/IAI.00064-15⟩
Article dans une revue hal-02634629 v1

Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic <em>Escherichia coli</em>

Thomas Secher , Ayaka Shima , Karen Hinsinger , Jean Christophe Cintrat , Ludger Johannes et al.
Antimicrobial Agents and Chemotherapy, 2015, 59 (8), pp.5010-5013. ⟨10.1128/AAC.00455-15⟩
Article dans une revue hal-02640796 v1
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Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis

Delphine Payros , Thomas Secher , Michèle Boury , Camille Brehin , Sandrine Ménard et al.
Gut Microbes, 2014, 5 (3), pp.313-325. ⟨10.4161/gmic.28932⟩
Article dans une revue hal-01859355 v2
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IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice

Rodrigo Guabiraba , Anne-Gaëlle Besnard , Gustavo Batista Menezes , Thomas Secher , M. S. Jabir et al.
Mucosal Immunology, 2014, 7 (5), pp.1079-1093. ⟨10.1038/mi.2013.124⟩
Article dans une revue hal-02633989 v1
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<em>Escherichia coli</em> producing colibactin triggers premature and transmissible senescence in mammalian cells

Thomas Secher , Ascel Samba Louaka , Eric Oswald , Jean-Philippe Nougayrède
PLoS ONE, 2013, 8 (10), ⟨10.1371/journal.pone.0077157⟩
Article dans une revue hal-02646496 v1

Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice

Bérengère Villeret , Lea Brault , Aurélie Couturier-Maillard , Pauline Robinet , Virginie Vasseur et al.
American journal of Clinical and Experimental Immunology, 2013, 2 (1), pp.107-116
Article dans une revue hal-02651056 v1

Dysbiosis, a new medical concept

Sylvain Normand , Thomas Secher , Mathias Chamaillard
Médecine/Sciences, 2013, 29 (6-7), pp.586-589. ⟨10.1051/medsci/2013296011⟩
Article dans une revue hal-02180092 v1
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NOD2 prevents emergence of disease-predisposing microbiota

Thomas Secher , Sylvain Normand , Mathias Chamaillard
Gut microbes, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩
Article dans une revue hal-02180087 v1

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

Aurélie Couturier-Maillard , Thomas Secher , Ateequr Rehman , Sylvain Normand , Adèle de Arcangelis et al.
Journal of Clinical Investigation, 2013, 123 (2), pp.700-11. ⟨10.1172/JCI62236⟩
Article dans une revue hal-00944194 v1
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Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

Maïwenn Olier , Ingrid Marcq , Christel Cartier , Thomas Secher , Ulrich Dobrindt et al.
Gut microbes, 2012, 3 (6), pp.501-509. ⟨10.4161/gutmicrobes.21737⟩
Article dans une revue hal-02935516 v1

Local and remote tissue injury upon intestinal ischemia and reperfusion depends on the TLR/MyD88 signaling pathway.

Tatiana Victoni , Fernando Rodrigues Coelho , Alexandre Learth Soares , Andressa de Freitas , Thomas Secher et al.
Medical Microbiology and Immunology, 2010, 199 (1), pp.35-42. ⟨10.1007/s00430-009-0134-5⟩
Article dans une revue istex hal-00591521 v1

Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.

Kevin N Couper , Tom Barnes , Julius C R Hafalla , Valery Combes , Bernhard Ryffel et al.
PLoS Pathogens, 2010, 6 (1), pp.e1000744. ⟨10.1371/journal.ppat.1000744⟩
Article dans une revue hal-00591502 v1

Remote control of intestinal tumorigenesis by innate immunity.

Thomas Secher , Olivier Gaillot , Bernhard Ryffel , Mathias Chamaillard
Cancer Research, 2010, 70 (5), pp.1749-52. ⟨10.1158/0008-5472.CAN-09-3401⟩
Article dans une revue hal-00591500 v1
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Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.

Laure Janot , Jean-Claude Sirard , Thomas Secher , Nicolas Noulin , Lizette Fick et al.
European Journal of Immunology, 2009, 39 (6), pp.1587-96. ⟨10.1002/eji.200838907⟩
Article dans une revue inserm-00385299 v1

IL-17 receptor signaling is required to control polymicrobial sepsis.

Andressa Freitas , José C Alves-Filho , Tatiana Victoni , Thomas Secher , Henrique P Lemos et al.
Journal of Immunology, 2009, 182 (12), pp.7846-54. ⟨10.4049/jimmunol.0803039⟩
Article dans une revue hal-00404905 v1

Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis.

Thomas Secher , Virginie Vasseur , Didier Marc Poisson , Jane A Mitchell , Fernando Q Cunha et al.
Journal of Immunology, 2009, 182 (12), pp.7855-64. ⟨10.4049/jimmunol.0804008⟩
Article dans une revue hal-00404907 v1

Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.

R. Dessein , M. Gironella , Clémentine Vignal , L. Peyrin-Biroulet , H. Sokol et al.
Gut, 2009, 58 (6), pp.771-6. ⟨10.1136/gut.2008.168443⟩
Article dans une revue istex hal-00404858 v1

CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection.

Laure Janot , Thomas Secher , David Torres , Isabelle Maillet , Josef Pfeilschifter et al.
Journal of Infectious Diseases, 2008, 198 (1), pp.115-24. ⟨10.1086/588815⟩
Article dans une revue hal-00318570 v1

Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury.

Dieudonnée Togbe , Silvia Schnyder-Candrian , Bruno Schnyder , Emilie Doz , Nicolas Noulin et al.
International Journal of Experimental Pathology, 2007, 88 (6), pp.387-91. ⟨10.1111/j.1365-2613.2007.00566.x⟩
Article dans une revue hal-00318537 v1

Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.

Jonathan Zalevsky , Thomas Secher , Sergei A Ezhevsky , Laure Janot , Paul M Steed et al.
Journal of Immunology, 2007, 179 (3), pp.1872-83
Article dans une revue hal-00318488 v1

Mucosal administration of anti-bacterial antibody (Ab) provides long-term cross-protection against Pseudomonas aeruginosa respiratory infection

Aubin Pitiot , Marion Ferreira , Christelle Parent , Chloé Boisseau , Mélanie Cortes et al.
Journées d'Animation Scientifique de la FéRI 2022 - FéRi Scientific Days 2022, Fédération de Recherche en Infectiologie (FéRI), Centre Val de Loire, Jul 2022, Joué-Lès-Tours, France
Communication dans un congrès hal-03735460 v1

A c-type lectin triggers immune surveillance by innate lymphoid cells for eradication of attaching-and-effacing bacteria

Bruno Lamas , Nadine Waldschmitt , Sho Kitamoto , Thomas Secher , Vassiliki Zacharioudaki et al.
25. United European Gastroenterology: Week, Oct 2017, Barcelone, Spain
Communication dans un congrès hal-02786603 v1

Pulmonary Delivery of Antibody for the Treatment of Respiratory Diseases

Thomas Secher , Nathalie Heuzé-Vourc’h
Springer; AAPS. Respiratory Delivery of Biologics, Nucleic Acids, and Vaccines, 8, Springer International Publishing, pp.21-51, 2024, AAPS Introductions in the Pharmaceutical Sciences, ⟨10.1007/978-3-031-47567-2_2⟩
Chapitre d'ouvrage hal-04834340 v1