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Timothée Bruel

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<a name="_Toc97800269"></a>Education ------------------------------------ 2009-2013 **PhD** in Immunology with honours “très honorable” at Ecole doctorale 425 (ED425) Innovation thérapeutique, Université Paris Sud, Orsay, France 2007-09 **Master Degree** in Infectious Disease, Immunology and vaccinology with honours, Université François Rabelais, Tours, France 2004-07 **Science Degree** in Biochemistry with honours at Université François Rabelais de Tours <a name="_Toc97800270"></a>Professionnal experiences ---------------------------------------------------- January 2018 – Now **Permanent researcher** Virus &amp; Immunity unit – Olivier Schwartz’s Lab, Institut Pasteur, Paris France “*Antiviral activities of anti-HIV-1 antibodies*” January 2019 – April 2019 **Visiting Scientist** Immunology unit – Tineke Cantaert’s Lab, Institut Pasteur du Cambodge, Phnom Penh, Cambodge “Complement and Dengue” September 2013 – December 2018 **Post-doctoral Fellow** Virus &amp; Immunity unit – Olivier Schwartz’s Lab, Institut Pasteur, Paris France “*Antiviral activities of anti-HIV-1 antibodies*” September 2009 – June 2013 **PhD Student** Division of immuno-virology, CEA, Fontenay-aux-roses, France “*Dynamics of Type I IFN and plasmacytoid dendritic cell in SIV primary infection*” under supervision of Dr. Bruno Vaslin

Publications

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Estimated protection against COVID-19 based on predicted neutralisation titres from multiple antibody measurements in a longitudinal cohort, France, April 2020 to November 2021

Tom Woudenberg , Laurie Pinaud , Laura Garcia , Laura Tondeur , Stephane Pelleau
Eurosurveillance, 2023, 28 (25), ⟨10.2807/1560-7917.ES.2023.28.25.2200681⟩
Journal articles hal-04146212v1
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Polyfunctionality of broadly neutralizing HIV-1 antibodies

Lou-Léna Vrignaud , Olivier Schwartz , Timothée Bruel
Current Opinion in HIV and AIDS, 2023, 18 (4), pp.178-183. ⟨10.1097/COH.0000000000000799⟩
Journal articles pasteur-04138728v1
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Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies

Delphine Planas , Timothée Bruel , Isabelle Staropoli , Florence Guivel-Benhassine , Françoise Porrot
Nature Communications, 2023, 14 (1), pp.824. ⟨10.1038/s41467-023-36561-6⟩
Journal articles hal-04087563v1
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High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1

William Bolland , Vincent Michel , Delphine Planas , Mathieu Hubert , Isabelle Staropoli
Journal of Virology, inPress, pp.e0135123. ⟨10.1128/jvi.01351-23⟩
Journal articles pasteur-04369613v1
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Complement contributes to antibody-mediated protection against repeated SHIV challenge

Benjamin Goldberg , David Spencer , Shilpi Pandey , Tracy Ordonez , Philip Barnette
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (20), pp.e2221247120. ⟨10.1073/pnas.2221247120⟩
Journal articles pasteur-04165265v1

Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals

Mathieu Hubert , Florence Guivel-Benhassine , Timothée Bruel , Françoise Porrot , Delphine Planas
Cell Host & Microbe, 2023, 31 (6), pp.937-948.e4. ⟨10.1016/j.chom.2023.05.001⟩
Journal articles hal-04309033v1
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Modeling the evolution of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2

Quentin Clairon , Mélanie Prague , Delphine Planas , Timothée Bruel , Laurent Hocqueloux
PLoS Computational Biology, 2023
Journal articles hal-03946556v1

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Olivier Schwartz , Thierry Prazuck , Benjamin Terrier , Emmanuel André , Etienne Simon-Loriere
Nature Medicine, 2022, ⟨10.1038/s41591-022-01792-5⟩
Journal articles pasteur-03654237v1
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Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

Nell Saunders , Delphine Planas , William Bolland , Christophe Rodriguez , Slim Fourati
EBioMedicine, 2022, 77, pp.103934. ⟨10.1016/j.ebiom.2022.103934⟩
Journal articles pasteur-03654246v1
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Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2

Cyril Planchais , Ignacio Fernández , Timothée Bruel , Guilherme Dias de Melo , Matthieu Prot
Journal of Experimental Medicine, 2022, 219 (7), pp.e20220638. ⟨10.1084/jem.20220638⟩
Journal articles hal-03697587v1
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Anti-CD38 therapy impairs SARS-CoV-2 vaccine response against alpha and delta variants in patients with multiple myeloma

Soledad Henriquez , Jérémie Zerbit , Timothée Bruel , Amani Ouedrani , Delphine Planas
Blood, 2022, 139 (6), pp.942-946. ⟨10.1182/blood.2021013714⟩
Journal articles pasteur-03696807v1

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization

Delphine Planas , Nell Saunders , Piet Maes , Florence Guivel-Benhassine , Cyril Planchais
Nature, 2022, 602 (7898), pp.671-675. ⟨10.1038/s41586-021-04389-z⟩
Journal articles pasteur-03654259v1

IRF8 regulates efficacy of therapeutic anti‐CD20 monoclonal antibodies

Ludivine Grzelak , Ferdinand Roesch , Amaury Vaysse , Anne Biton , Rachel Legendre
European Journal of Immunology, 2022, 52 (10), pp.1648-1661. ⟨10.1002/eji.202250037⟩
Journal articles hal-03833626v1

Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases

Jerome Hadjadj , Delphine Planas , Amani Ouedrani , Solene Buffier , Laure Delage
Annals of the Rheumatic Diseases, 2022, 81 (5), pp.720-728. ⟨10.1136/annrheumdis-2021-221508⟩
Journal articles hal-03698561v1

A fourth dose of the mRNA-1273 SARS-CoV-2 vaccine improves serum neutralization against the Delta variant in kidney transplant recipients

Ilies Benotmane , Timothée Bruel , Delphine Planas , Samira Fafi-Kremer , Olivier Schwartz
Kidney International, 2022, 101 (5), pp.1073-1076. ⟨10.1016/j.kint.2022.02.011⟩
Journal articles pasteur-03696743v1
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Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen

Alice Mac Kain , Ghizlane Maarifi , Sophie-Marie Aicher , Nathalie Arhel , Artem Baidaliuk
Nature Communications, 2022, 13, 13 p. ⟨10.1038/s41467-022-30134-9⟩
Journal articles pasteur-03707111v2
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Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis

David Spencer , Benjamin Goldberg , Shilpi Pandey , Tracy Ordonez , Jérémy Dufloo
Nature Communications, 2022, 13 (1), pp.662. ⟨10.1038/s41467-022-28250-7⟩
Journal articles pasteur-03696775v1
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Neutralising antibody responses to SARS-CoV-2 omicron among elderly nursing home residents following a booster dose of BNT162b2 vaccine: A community-based, prospective, longitudinal cohort study

Timothée Bruel , Laurie Pinaud , Laura Tondeur , Delphine Planas , Isabelle Staropoli
EClinicalMedicine, 2022, 51, pp.101576. ⟨10.1016/j.eclinm.2022.101576⟩
Journal articles hal-03740505v1

Duration of BA.5 neutralization in sera and nasal swabs from SARS-CoV-2 vaccinated individuals, with or without omicron breakthrough infection

Delphine Planas , Isabelle Staropoli , Françoise Porot , Florence Guivel-Benhassine , Lynda Handala
Med, 2022, 3 (12), pp.838-847.e3. ⟨10.1016/j.medj.2022.09.010⟩
Journal articles pasteur-04082610v1

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies

Delphine Planas , Timothée Bruel , Isabelle Staropoli , Florence Guivel-Benhassine , Françoise Porrot
bioRxiv : the preprint server for biology, 2022, ⟨10.1101/2022.11.17.516888⟩
Journal articles pasteur-04082579v1
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Case Report: Evolution of Humoral and Cellular Immunity in Two COVID-19 Breakthrough Infections After BNT162b2 Vaccine

Floriane Gallais , Pierre Gantner , Delphine Planas , Morgane Solis , Timothée Bruel
Frontiers in Immunology, 2022, 13, pp.790212. ⟨10.3389/fimmu.2022.790212⟩
Journal articles pasteur-03696752v1
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Longitudinal analysis of serum neutralization of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 in patients receiving monoclonal antibodies

Timothée Bruel , Karl Stéfic , Yann Nguyen , Donatella Toniutti , Isabelle Staropoli
Cell Reports Medicine, 2022, 3 (12), pp.100850. ⟨10.1016/j.xcrm.2022.100850⟩
Journal articles pasteur-04165260v1
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Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

Jonathan Torres , Gabriel Ozorowski , Emanuele Andreano , Hejun Liu , Jeffrey Copps
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (20), pp.e2120976119. ⟨10.1073/pnas.2120976119⟩
Journal articles pasteur-04082754v1
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Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination

Laura Garcia , Tom Woudenberg , Jason Rosado , Adam Dyer , Françoise Donnadieu
Viruses, 2022, Special Issue SARS-CoV-2 Research in France, 14 (7), pp.1491. ⟨10.3390/v14071491⟩
Journal articles pasteur-04082742v1

COVID-19 outbreak in vaccinated patients from a haemodialysis unit: antibody titres as a marker of protection from infection

Idris Boudhabhay , Alexandra Serris , Aude Servais , Delphine Planas , Aurélie Hummel
Nephrology Dialysis Transplantation, 2022, pp.gfac016. ⟨10.1093/ndt/gfac016⟩
Journal articles pasteur-03696758v1
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Robust and Functional Immune Memory Up to 9 Months After SARS-CoV-2 Infection: A Southeast Asian Longitudinal Cohort

Hoa Thi My Vo , Alvino Maestri , Heidi Auerswald , Sopheak Sorn , Sokchea Lay
Frontiers in Immunology, 2022, 13, pp.817905. ⟨10.3389/fimmu.2022.817905⟩
Journal articles pasteur-03654271v1
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Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells

Jérémy Dufloo , Cyril Planchais , Stéphane Frémont , Valerie Lorin , Florence Guivel-Benhassine
Nature Communications, 2022, 13 (1), pp.630. ⟨10.1038/s41467-022-28307-7⟩
Journal articles pasteur-03654220v1

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

Delphine Planas , Timothée Bruel , Ludivine Grzelak , Florence Guivel-Benhassine , Isabelle Staropoli
Nature Medicine, 2021, ⟨10.1038/s41591-021-01318-5⟩
Journal articles pasteur-03207907v1
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Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2

Ludivine Grzelak , Auréie Velay-Rusch , Yoann Madec , Floriane Gallais , Isabelle Staropoli
Journal of Infectious Diseases, 2021, 224 (6), pp.983-988. ⟨10.1093/infdis/jiab127⟩
Journal articles hal-03606632v1

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas , David Veyer , Artem Baidaliuk , Isabelle Staropoli , Florence Guivel-Benhassine
Nature, 2021, 596 (7871), pp.276-280. ⟨10.1038/s41586-021-03777-9⟩
Journal articles pasteur-03696844v1
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Evolution of antibody responses up to 13 months after SARS-CoV-2 infection and risk of reinfection

Floriane Gallais , Pierre Gantner , Timothée Bruel , Aurélie Velay , Delphine Planas
EBioMedicine, 2021, 71, pp.103561. ⟨10.1016/j.ebiom.2021.103561⟩
Journal articles hal-03500711v1
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Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection

Nader Yatim , Jeremy Boussier , Pauline Tetu , Nikaïa Smith , Timothée Bruel
Science Advances , 2021, 7 (34), pp.eabg4081. ⟨10.1126/sciadv.abg4081⟩
Journal articles pasteur-03334080v1
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Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection

Stéphane Pelleau , Tom Woudenberg , Jason Rosado , Françoise Donnadieu , Laura Garcia
Journal of Infectious Diseases, 2021, 224 (9), pp.1489-1499. ⟨10.1093/infdis/jiab375⟩
Journal articles pasteur-03319587v2
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Multiplex assays for the identification of serological signatures of SARS-CoV-2 infection: an antibody-based diagnostic and machine learning study

Jason Rosado , Stéphane Pelleau , Charlotte A. Cockram , Sarah Hélène Merkling , Narimane Nekkab
The Lancet Microbe, 2021, 2 (2), pp.e60-e69. ⟨10.1016/S2666-5247(20)30197-X⟩
Journal articles hal-03128905v1
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Sera neutralizing activities against SARS-CoV-2 and multiple variants six month after hospitalization for COVID-19

Maureen Betton , Marine Livrozet , Delphine Planas , Antoine Fayol , Blandine Monel
Clinical Infectious Diseases, 2021, pp.ciab308. ⟨10.1093/cid/ciab308⟩
Journal articles pasteur-03229817v1
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Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

Nikaïa Smith , Pedro Goncalves , Bruno Charbit , Ludivine Grzelak , Maxime Beretta
Nature Immunology, 2021, ⟨10.1038/s41590-021-01028-7⟩
Journal articles pasteur-03384279v1
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Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

Benjamin S. Goldberg , Chengzi I. Kaku , Jérémy Dufloo , Timothée Bruel , Olivier Schwartz
mBio, 2021, 12 (5), pp.e01743-21. ⟨10.1128/mBio.01743-21⟩
Journal articles pasteur-03696816v1
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Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

Romain Marlin , Veronique Godot , Sylvain Cardinaud , Mathilde Galhaut , Severin Coleon
Nature Communications, 2021, 12, pp.5215. ⟨10.1038/s41467-021-25382-0⟩
Journal articles hal-03481526v1

Characteristics Associated with Olfactory and Taste Disorders in COVID-19

Simon Galmiche , Timothée Bruel , Yoann Madec , Laura Tondeur , Ludivine Grzelak
Neuroepidemiology, 2021, 55 (5), pp.381-386. ⟨10.1159/000517066⟩
Journal articles hal-03528578v1
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Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

Romain Marlin , Veronique Godot , Sylvain Cardinaud , Mathilde Galhaut , Severin Coleon
Nature Communications, 2021, 12, ⟨10.1038/s41467-021-25382-0⟩
Journal articles hal-04510002v1
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Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

Stéphane Marot , Isabelle Malet , Valentin Leducq , Karen Zafilaza , Delphine Sterlin
Nature Communications, 2021, 12 (1), pp.844. ⟨10.1038/s41467-021-21111-9⟩
Journal articles hal-03138467v1
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SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance

Rémy Robinot , Mathieu Hubert , Guilherme Dias de Melo , Françoise Lazarini , Timothée Bruel
Nature Communications, 2021, 12 (1), pp.4354. ⟨10.1038/s41467-021-24521-x⟩
Journal articles pasteur-03319522v1
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Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies

Jérémy Dufloo , Ludivine Grzelak , Isabelle Staropoli , Yoann Madec , Laura Tondeur
Cell Reports Medicine, 2021, 2 (5), pp.100275. ⟨10.1016/j.xcrm.2021.100275⟩
Journal articles pasteur-03229805v1
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SARS-CoV-2 infection in schools in a northern French city: a retrospective serological cohort study in an area of high transmission, France, January to April 2020

Arnaud Fontanet , Laura Tondeur , Rebecca Grant , Sarah Temmam , Yoann Madec
Eurosurveillance, 2021, 26 (15), pp.2001695. ⟨10.2807/1560-7917.es.2021.26.15.2001695⟩
Journal articles pasteur-03236257v1
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Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study

Blandine Monel , Delphine Planas , Ludivine Grzelak , Nikaïa Smith , Nicolas Robillard
EBioMedicine, 2021, 73, pp.103637. ⟨10.1016/j.ebiom.2021.103637⟩
Journal articles hal-03408666v1

Author Correction: Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers

Stéphane Marot , Isabelle Malet , Valentin Leducq , Karen Zafilaza , Delphine Sterlin
Nature Communications, 2021, 12 (1), pp.2824. ⟨10.1038/s41467-021-23128-6⟩
Journal articles hal-03997295v1
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Transmission of SARS-CoV-2 Alpha Variant (B.1.1.7) From a BNT162b2-Vaccinated Individual

Solen Kernéis , Delphine Planas , Sandrine Imbeaud , Isabelle Staropoli , Julien Puech
Open Forum Infectious Diseases, 2021, 8 (8), pp.ofab369. ⟨10.1093/ofid/ofab369⟩
Journal articles pasteur-03696825v1

Syncytia formation by SARS‐CoV‐2‐infected cells

Julian Buchrieser , Jérémy Dufloo , Mathieu Hubert , Blandine Monel , Delphine Planas
EMBO Journal, 2020, 39 (23), pp.e106267. ⟨10.15252/embj.2020106267⟩
Journal articles pasteur-03253133v1

Flow Cytometry Analysis of HIV-1 Env Conformations at the Surface of Infected Cells and Virions: Role of Nef, CD4, and SERINC5

Isabelle Staropoli , Jérémy Dufloo , Anaïs Ducher , Pierre-Henri Commère , Anna Sartori-Rupp
Journal of Virology, 2020, 94 (6), ⟨10.1128/JVI.01783-19⟩
Journal articles pasteur-02561978v1
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Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France

Samira Fafi-Kremer , Timothée Bruel , Yoann Madec , Rebecca Grant , Laura Tondeur
EBioMedicine, 2020, 59, pp.102915. ⟨10.1016/j.ebiom.2020.102915⟩
Journal articles hal-03606631v1
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A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

Ludivine Grzelak , Sarah Temmam , Cyril Planchais , Caroline Demeret , Laura Tondeur
Science Translational Medicine, 2020, 12 (559), pp.eabc3103. ⟨10.1126/scitranslmed.abc3103⟩
Journal articles pasteur-03139185v1
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IgA dominates the early neutralizing antibody response to SARS-CoV-2

Delphine Sterlin , Alexis Mathian , Makoto Miyara , Audrey Mohr , François Anna
Science Translational Medicine, 2020, pp.eabd2223. ⟨10.1126/scitranslmed.abd2223⟩
Journal articles hal-03105620v1
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Anti‐ HIV ‐1 antibodies trigger non‐lytic complement deposition on infected cells

Jérémy Dufloo , Florence Guivel-Benhassine , Julian Buchrieser , Valérie Lorin , Ludivine Grzelak
EMBO Reports, 2019, 21 (2), pp.e49351. ⟨10.15252/embr.201949351⟩
Journal articles pasteur-03239697v1
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Structural Basis for Broad HIV-1 Neutralization by a Novel MPER-Specific Human Broadly Neutralizing Antibody

Dora Pinto , Craig Fenwick , Christophe Caillat , Chiara Silacci , Serafima Guseva
Cell Host and Microbe, 2019, 26 (5), pp.623-637.e8. ⟨10.2139/ssrn.3416843⟩
Journal articles hal-02336304v1
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HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells

Cyril Planchais , Ayrin Kök , Alexia Kanyavuz , Valérie Lorin , Timothée Bruel
Cell Reports, 2019, 27 (2), pp.572-585.e7. ⟨10.1016/j.celrep.2019.03.032⟩
Journal articles hal-02102470v1

Accelerated thymopoiesis and improved T‐cell responses in HLA‐A2/‐DR2 transgenic BRGS‐based human immune system mice

Guillemette Masse-Ranson , Mathilde Dusseaux , Oriane Fiquet , Sylvie Darche , Maud Boussand
European Journal of Immunology, 2019, 49 (6), pp.954-965. ⟨10.1002/eji.201848001⟩
Journal articles pasteur-02875581v1
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Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection

Nadia Echebli , Nicolas Tchitchek , Stéphanie Dupuy , Timothée Bruel , Caroline Passaes
PLoS ONE, 2018, 13 (1), pp.e0190334. ⟨10.1371/journal.pone.0190334⟩
Journal articles pasteur-02861901v1
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Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

Julie Prigent , Annaëlle Jarossay , Cyril Planchais , Caroline Eden , Jérémy Dufloo
Cell Reports, 2018, 23 (9), pp.2568-2581. ⟨10.1016/j.celrep.2018.04.101⟩
Journal articles hal-01803507v1

A human immune system mouse model with robust lymph node development

Yan Li , Guillemette Masse-Ranson , Zacarias Garcia , Timothée Bruel , Ayrin Kök
Nature Methods, 2018, 15 (8), pp.623-630. ⟨10.1038/s41592-018-0071-6⟩
Journal articles pasteur-02875578v1

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents

Caroline Pereira Bittencourt Passaes , Timothée Bruel , Jérémie Decalf , Annie David , Mathieu Angin
Journal of Virology, 2017, 91 (6), pp.e02296-16. ⟨10.1128/JVI.02296-16⟩
Journal articles pasteur-01484315v1

Zika virus induces massive cytoplasmic vacuolization and paraptosis‐like death in infected cells

Blandine Monel , Alex Compton , Timothée Bruel , Sonia Amraoui , Julien Burlaud-Gaillard
EMBO Journal, 2017, 36 (12), pp.1653-1668. ⟨10.15252/embj.201695597⟩
Journal articles pasteur-03253584v1

Corrigendum: CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

B Descours , G Petitjean , Jl López-Zaragoza , T Bruel , R Raffel
Nature, 2017, 546 (7660), pp.686. ⟨10.1038/nature22807⟩
Journal articles hal-01503531v1

Lack of ADCC breadth of human non-neutralizing anti-HIV-1 antibodies.

Timothée Bruel , Florence Guivel-Benhassine , Valérie Lorin , Hugues Lortat-Jacob , Françoise Baleux
Journal of Virology, 2017, 91 (8), pp.e02440-16. ⟨10.1128/JVI.02440-16⟩
Journal articles hal-01487928v1

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

Benjamin Descours , Gaël Petitjean , José-Luis López-Zaragoza , Timothée Bruel , Raoul Raffel
Nature, 2017, 543 (7646), pp.564 - 567. ⟨10.1038/nature21710⟩
Journal articles hal-01777383v1

HIV Fusion in Dendritic Cells Occurs Mainly at the Surface and Is Limited by Low CD4 Levels

Lise Chauveau , Daniel Aaron Donahue , Blandine Monel , Francoise Porrot , Timothée Bruel
Journal of Virology, 2017, 91 (21), ⟨10.1128/JVI.01248-17⟩
Journal articles pasteur-03253577v1
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CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge.

Kevin K Ariën , Françoise Baleux , Delphine Desjardins , Françoise Porrot , Yves-Marie Coïc
Scientific Reports, 2016, 6, pp.34829. ⟨10.1038/srep34829⟩
Journal articles pasteur-01423094v1

Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity

Valérie Lorin , M Malbec , C Eden , T Bruel , F Porrot
Mucosal Immunology, 2016, ⟨10.1038/mi.2016.106⟩
Journal articles pasteur-01417469v1
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Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles

Chiraz Hamimi , Annie David , Pierre Versmisse , Laurence Weiss , Timothée Bruel
PLoS ONE, 2016, 11 (8), pp.e0160251. ⟨10.1371/journal.pone.0160251⟩
Journal articles hal-01375755v1

SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells.

Diana Ayinde , Timothée Bruel , Sylvain Cardinaud , Françoise Porrot , Julia G Prado
Journal of Virology, 2015, 89 (14), pp.6994-7006. ⟨10.1128/JVI.00069-15⟩
Journal articles pasteur-01372403v1
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Long-Term Control of Simian Immunodeficiency Virus (SIV) in Cynomolgus Macaques Not Associated with Efficient SIV-Specific CD8 + T-Cell Responses.

Timothée Bruel , Chiraz Hamimi , Nathalie Dereuddre-Bosquet , Antonio Cosma , So Youn Shin
Journal of Virology, 2015, 89 (7), pp.3542 - 3556. ⟨10.1128/JVI.03723-14⟩
Journal articles pasteur-01414959v1
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Elimination of HIV-1-infected cells by broadly neutralizing antibodies.

Timothée Bruel , Florence Guivel-Benhassine , Sonia Amraoui , Marine Malbec , Léa Richard
Nature Communications, 2015, 7, pp.10844. ⟨10.1038/ncomms10844⟩
Journal articles pasteur-01372390v1

IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread.

Alex A Compton , Timothée Bruel , Françoise Porrot , Adeline Mallet , Martin Sachse
Cell Host and Microbe, 2014, 16 (6), pp.736-47. ⟨10.1016/j.chom.2014.11.001⟩
Journal articles pasteur-01109877v1

Plasmacytoid Dendritic Cell Dynamics Tune Interferon-Alfa Production in SIV-Infected Cynomolgus Macaques

Timothée Bruel , Stéphanie Dupuy , Thomas Démoulins , Christine Rogez-Kreuz , Jacques Dutrieux
PLoS Pathogens, 2014, 10 (1), pp.e1003915. ⟨10.1371/journal.ppat.1003915⟩
Journal articles hal-02940446v1

Porcine colon explants in the study of innate immune response to Entamoeba histolytica

Fabienne Girard-Misguich , Mario Delgado-Ortega , Patricia Berthon , Christelle Rossignol , Thibaut T. Larcher
Veterinary Immunology and Immunopathology, 2012, 145 (3-4), pp.611-617. ⟨10.1016/j.vetimm.2012.01.002⟩
Journal articles hal-02650556v1
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Towards the establishment of a porcine model to study human amebiasis.

Fabienne Girard-Misguich , Juliette Cognie , Mario Delgado-Ortega , Patricia Berthon , Christelle Rossignol
PLoS ONE, 2011, 6 (12), ⟨10.1371/journal.pone.0028795⟩
Journal articles hal-01129611v1

Epithelial induction of porcine suppressor of cytokine signaling 2 (SOCS2) gene expression in response to Entamoeba histolytica

Timothée Bruel , Roseline Guibon , Sandrina Melo , Nancy Guillén , Henri H. Salmon
Developmental and Comparative Immunology, 2010, 34 (5), pp.562-571. ⟨10.1016/j.dci.2009.12.017⟩
Journal articles hal-02665993v1
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Expression and immunogenicity of the mycobacterial Ag85B/ESAT-6 antigens produced in transgenic plants by elastin-like peptide fusion strategy.

Doreen Manuela Floss , Michael Mockey , Galliano Zanello , Damien Brosson , Marie Diogon
Journal of Biomedicine and Biotechnology, 2010, 2010, pp.274346. ⟨10.1155/2010/274346⟩
Journal articles hal-00528178v1

Amibiase humaine : établissement d'un modèle porcin

Francois Meurens , F Girard-Misguich , T Bruel , R Guibon , S Melo
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu
Conference papers hal-02818906v1