Vincent AUCAGNE
22
Documents
Identifiants chercheurs
- vincent-aucagne
- 0000-0002-2647-0188
- IdRef : 077138120
Présentation
EDUCATION
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- 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology
- 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans
PROFESSIONAL EXPERIENCES
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- 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins
- 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures
- 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities
- 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions
- 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates
RESEARCH INTERESTS
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- Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.
- Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification
- Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry
- Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.
- Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies
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Treating mares with the long-acting kisspeptin analog C6 increases circulating gonadotropins but does not trigger ovulationAgriculture, 2022, 12 (11), pp.1846. ⟨10.3390/agriculture12111846⟩
Article dans une revue
hal-03862471v1
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The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goatPLoS ONE, 2019, 14 (3), pp.e0214424. ⟨10.1371/journal.pone.0214424⟩
Article dans une revue
hal-02088631v1
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A synthetic kisspeptin analog that triggers ovulation and advances pubertyScientific Reports, 2016, 6 (1), pp.26908. ⟨10.1038/srep26908⟩
Article dans une revue
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Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of GonadotropinsJournal of Medicinal Chemistry, 2015, 58 (8), pp.3459-3470. ⟨10.1021/jm5019675⟩
Article dans une revue
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Rational design of kisspeptin analogs for the control of reproduction4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium
Communication dans un congrès
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Design and profiling of new selective KISS1R agonists that stimulate the reproductive system8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia
Communication dans un congrès
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New KISS1R agonists with potential for the treatment of reproductive disorder11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria
Communication dans un congrès
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Rational design of kisspeptin analogs for the control of the reproductive system25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France
Poster de conférence
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In non-breeding ewes the kisspeptin analog c6 triggers ovulation without progestogen priming9th International Congress of Neuroendocrinology, Jul 2018, Toronto, Canada. , 2018, The 9th International Congress of Neuroendocrinology. Abstract book
Poster de conférence
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Long-lasting increase of gonadotropins by rational design of lipophilic kisspeptin analogs2018 International Symposium on Chemical Biology, Jan 2018, Genève, Switzerland
Poster de conférence
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The kisspeptin analog C6 triggers ovulation in non-breeding ewe in the absence of progestogen priming9. International Congress of Neuroendocrinology (ICN 2018), Jul 2018, Toronto, Canada
Poster de conférence
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Investigation of tachyphylaxis of LH response following repeated injections of the kisspeptin analog C6Colloque International NeuroFrance 2017, May 2017, Bordeaux, France. 2017, Colloque International NeuroFrance 2017
Poster de conférence
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Pattern of LH secretion after repeated treatment with kisspeptin analog C6 reveals differential sensitivity between mice and ewes42. Colloque de la société de neuroendocrinologie (SNE 2017), Sep 2017, Dijon, France
Poster de conférence
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Investigation of a kisspeptin analog effects both on synchronization of ovulation and puberty onset in domestic mammals and in rodentsReproSciences 2017, Apr 2017, Tours, France. 75 p., 2017, 2èmes Journées Scientifiques du GdR Repro
Poster de conférence
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A new selective kisspeptin analog, C6, that advance puberty in mice and stimulate fertile ovulation in eweBritish Society for Neuroendocrinology Annual Meeting, Sep 2016, Glasgow, United Kingdom
Poster de conférence
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Induction of fertile ovulation and puberty advancement by a new kisspeptin analog18th International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR)
Poster de conférence
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Induction of synchronized fertile ovulation by a new selective agonist of kisspeptin receptor1 Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro
Poster de conférence
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Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins24. Meeting of the American Peptide Society, Jun 2015, Orlando, United States. 2015, 24th Meeting of the American Peptide Society
Poster de conférence
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Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotrophins19. Congrès du Groupe Français des Peptides et des Protéines, May 2015, Port-Bail, United States. 2015
Poster de conférence
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Development of new kisspeptin analogs to stimulate the reproductive systemInternational Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. , 2014, ICGRIII International Conference on Gonadotropins & Receptors
Poster de conférence
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Design and functional profiling of new KISS1R agonists2. Annual Meeting of the GDR RCPG-PhysioMed, Oct 2013, Illkirch, France. 2013, 2nd Annual Meeting of the GDR RCPG-PhysioMed
Poster de conférence
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La kisspeptine : une nouvelle voie pour maitriser l’ovulation chez les petits ruminants ?5. Journées d'Animation Scientifique du département Phase (JAS Phase 2013), Oct 2013, Paris, France. 2013
Poster de conférence
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