Vincent AUCAGNE

169
Documents

Présentation

EDUCATION

  • 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology

  • 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans

PROFESSIONAL EXPERIENCES

  • 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins
  • 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures
  • 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities
  • 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions
  • 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates

RESEARCH INTERESTS

  • Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.

  • Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification

  • Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry

  • Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.

  • Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies

Publications

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Publications

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Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L

Kang Zhu , Chatrin Chatrin , Marcin J Suskiewicz , Vincent Aucagne , Benjamin Foster et al.
EMBO Reports, 2024, 25 (10), pp.4172-4189. ⟨10.1038/s44319-024-00235-1⟩
Article dans une revue hal-04739061 v1
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An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates

Ana Novak , Florian Kersaudy , Sylvie Berger , Séverine Morisset-Lopez , François Lefoulon et al.
European Journal of Medicinal Chemistry, 2023, 260, pp.115747. ⟨10.1016/j.ejmech.2023.115747⟩
Article dans une revue hal-04222710 v1
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DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

Kang Zhu , Marcin Suskiewicz , Andrea Hloušek-Kasun , Hervé Meudal , Andreja Mikoč et al.
Science Advances , 2022, 8 (40), ⟨10.1126/sciadv.add4253⟩
Article dans une revue hal-03862525 v1
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Treating mares with the long-acting kisspeptin analog C6 increases circulating gonadotropins but does not trigger ovulation

Flavie Derouin Tochon , Didier Lomet , Vincent Robert , Fabrice Reigner , Philippe Barrière et al.
Agriculture, 2022, 12 (11), pp.1846. ⟨10.3390/agriculture12111846⟩
Article dans une revue hal-03862471 v1
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Functional Diversification of Oyster Big Defensins Generates Antimicrobial Specificity and Synergy against Members of the Microbiota

Noémie de San Nicolas , Aromal Asokan , Rafael D Rosa , Sébastien N Voisin , Marie-Agnès Travers et al.
Marine drugs, 2022, 20 (12), pp.745. ⟨10.3390/md20120745⟩
Article dans une revue hal-04246173 v1
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Real-Time Fluorescence Microscopy on Living E. coli Sheds New Light on the Antibacterial Effects of the King Penguin beta-Defensin AvBD103b

Céline Landon , Yanyu Zhu , Mainak Mustafi , Jean-Baptiste Madinier , Dominique Lelièvre et al.
International Journal of Molecular Sciences, 2022, This article belongs to the Special Issue Antimicrobial Peptides: Structure and Mechanism of Biological Activity, 23 (2057), pp.2057. ⟨10.3390/ijms23042057⟩
Article dans une revue hal-03860107 v1
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Aphid BCR4 Structure and Activity Uncover a New Defensin Peptide Superfamily

Karine Loth , Nicolas Parisot , Françoise Paquet , Hugo Terrasson , Catherine Sivignon et al.
International Journal of Molecular Sciences, 2022, 23 (20), pp.12480. ⟨10.3390/ijms232012480⟩
Article dans une revue hal-03862651 v1

The Kisspeptin analogue C6 induces ovulation in jennies

Diana Fanelli , Massimiliano Beltramo , Giuseppe Conte , Benedetta Cerretini , Didier Lomet et al.
Theriogenology, 2022, 189, pp.107-112. ⟨10.1016/j.theriogenology.2022.06.014⟩
Article dans une revue hal-03746194 v1
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Enzyme‐Cleavable Linkers for Protein Chemical Synthesis through Solid‐Phase Ligations

Skander A Abboud , Mehdi Amoura , J.B Madinier , Brigitte Renoux , Sébastien Papot et al.
Angewandte Chemie International Edition, 2021, 60 (34), pp.18612-18618. ⟨10.1002/anie.202103768⟩
Article dans une revue hal-03335485 v1
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Des protéines de synthèse taillées sur mesure pour investiguer le vivant

Vincent Aucagne , Fabienne Burlina , Oleg Melnyk , Vladimir Torbeev
L'Actualité Chimique, 2021, 468, pp.26-28
Article dans une revue hal-02959387 v1
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A straightforward methodology to overcome solubility challenges for N-terminal cysteinyl peptide segments used in native chemical ligation

Skander A Abboud , Hadji H. , Michel Doudeau , Hélène Bénédetti , Vincent Aucagne
Chemical Science, 2021, 12, pp.3194 - 3201. ⟨10.1039/d0sc06001a⟩
Article dans une revue hal-03447239 v1
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Lanthanide DO3A-Complexes Bearing Peptide Substrates: The Effect of Peptidic Side Chains on Metal Coordination and Relaxivity

Sophie Laine , Jean-François Morfin , Mathieu Galibert , Vincent Aucagne , Celia ́ Bonnet et al.
Molecules, 2021, 26 (8), pp.2176. ⟨10.3390/molecules26082176⟩
Article dans une revue hal-03437152 v1
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Monitoring Human Neutrophil Activation by a Proteinase 3 Near-Infrared Fluorescence Substrate-Based Probe

Ahlame Saidi , Mylène Wartenberg , J.B Madinier , Guy Ilango , Seda Seren et al.
Bioconjugate Chemistry, 2021, 32 (8), pp.1782-1790. ⟨10.1021/acs.bioconjchem.1c00267⟩
Article dans une revue hal-03525228 v1

Enzyme‐Cleavable Linkers for Protein Chemical Synthesis through Solid‐Phase Ligations

Skander Abboud , Mehdi Amoura , Jean-Baptiste Madinier , Brigitte Renoux , Sébastien Papot et al.
Angewandte Chemie International Edition, 2021, 60 (34), pp.18612-18618. ⟨10.1002/anie.202103768⟩
Article dans une revue hal-05019646 v1
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An optimized protocol for the synthesis of N -2-hydroxybenzyl-cysteine peptide crypto-thioesters

Skander A. Abboud , Vincent Aucagne
Organic & Biomolecular Chemistry, 2020, 18 (40), pp.8199-8208. ⟨10.1039/d0ob01737j⟩
Article dans une revue hal-02975540 v1
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Structure, function, and evolution of Gga -AvBD11, the archetype of the structural avian-double-β-defensin family

Nicolas Guyot , Herve Meudal , Sascha Trapp , Sophie Iochmann , Anne Silvestre et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (1), pp.337-345. ⟨10.1073/pnas.1912941117⟩
Article dans une revue hal-02522250 v1
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Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights

Charlotte Rieux , Stéphane Goffinont , Franck Coste , Zahira Tber , Julien Cros et al.
International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩
Article dans une revue hal-03082414 v1
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Near-infrared emitting lanthanide(III) complexes as prototypes of optical imaging agents with peptide targeting ability: a methodological approach

Monika Cieslikiewicz-Bouet , Svetlana Eliseeva , Vincent Aucagne , A.F. Delmas , Isabelle Gillaizeau et al.
RSC Advances, 2019, 9 (3), pp.1747-1751. ⟨10.1039/c8ra09419e⟩
Article dans une revue hal-02064990 v1
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The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial Nanonets

Karine Loth , Agnès Vergnes , Cairé Barreto , Sébastien N Voisin , Hervé Meudal et al.
mBio, 2019, 10 (5), pii: e01821-19. ⟨10.1128/mBio.01821-19⟩
Article dans une revue hal-02328576 v1

Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe

Mylène Wartenberg , Ahlame Saidi , Mathieu Galibert , Alix Joulin-Giet , Julien Burlaud-Gaillard et al.
Biochimie, 2019, 166, pp.84-93. ⟨10.1016/j.biochi.2019.03.013⟩
Article dans une revue hal-03677252 v1

Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves

P.A. Parker , E.A. Coffman , K.G. Pohler , J.A. Daniel , V. Aucagne et al.
Theriogenology, 2019, 130, pp.111-119. ⟨10.1016/j.theriogenology.2019.03.002⟩
Article dans une revue hal-02088608 v1
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The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat

Caroline Decourt , Vincent Robert , Didier Lomet , Karine Anger , Marion Georgelin et al.
PLoS ONE, 2019, 14 (3), pp.e0214424. ⟨10.1371/journal.pone.0214424⟩
Article dans une revue hal-02088631 v1
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In silico peptide ligation: Iterative Residue Docking and Linking as a new approach to predict protein-peptide interactions

Julien Diharce , Mickaël Cueto , Massimiliano Beltramo , Vincent Aucagne , Pascal Bonnet
Molecules, 2019, 24 (7), pp.1-14. ⟨10.3390/molecules24071351⟩
Article dans une revue hal-03525312 v1
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Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe

Mylène Wartenberg , Ahlame Saidi , Mathieu Galibert , Alix Joulin-Giet , Julien Burlaud-Gaillard et al.
Biochimie, 2019, 166, pp.84-93. ⟨10.1016/j.biochi.2019.03.013⟩
Article dans une revue hal-02088627 v1

Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S

Matthieu Galibert , Mylène Wartenberg , Fabien Lecaille , Ahlame Saidi , Sylvie Mavel et al.
European Journal of Medicinal Chemistry, 2018, 144, pp.201-210. ⟨10.1016/j.ejmech.2017.12.012⟩
Article dans une revue hal-03677245 v1
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-Mediated conjugation

David Montoir , Mehdi Amora , Zine El Abidine Aabasa , Thimmalapura Marulappa Vishwanatha , Expédite Yen-Pon et al.
Chemical Science, 2018, 9 (46), pp.8753-8759. ⟨10.1039/C8SC02370K⟩
Article dans une revue hal-02622102 v1

Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S

Matthieu Galibert , Mylène Wartenberg , Fabien Lecaille , Ahlame Saidi , Sylvie Mavel et al.
European Journal of Medicinal Chemistry, 2018, 144, pp.201 - 210. ⟨10.1016/j.ejmech.2017.12.012⟩
Article dans une revue hal-01702303 v1

Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus , improves sperm motility and fertilization in different mammalian species

Guillaume Martinez , Jean-Pascal Hograindleur , Sébastien Voisin , Roland Abi Nahed , Tarek M. Abd El Aziz et al.
Molecular Human Reproduction, 2017, 23 (2), pp.116-131. ⟨10.1093/molehr/gaw075⟩
Article dans une revue hal-01618630 v1

Efficient synthesis of cysteine-rich cyclic peptides through intramolecular native chemical ligation of N-Hnb-Cys peptide crypto-thioesters

Victor Terrier , Agnès F. Delmas , Vincent Aucagne
Organic & Biomolecular Chemistry, 2017, 15 (2), pp.316 - 319. ⟨10.1039/c6ob02546c⟩
Article dans une revue hal-01618781 v1

A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters

Victor P. Terrier , Hélène Adihou , Mathieu Arnould , Agnès F. Delmas , Vincent Aucagne
Chemical Science, 2016, 7 (1), pp.339 - 345. ⟨10.1039/C5SC02630J⟩
Article dans une revue hal-01407765 v1

A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis

Michael T. Jacobsen , Mark E. Petersen , Xiang Ye , Mathieu Galibert , George H. Lorimer et al.
Journal of the American Chemical Society, 2016, 138 (36), pp.11775 - 11782. ⟨10.1021/jacs.6b05719⟩
Article dans une revue hal-01407028 v1
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A synthetic kisspeptin analog that triggers ovulation and advances puberty

Caroline Decourt , Vincent Robert , Karine Anger , Mathieu Galibert , Jean-Baptiste Madinier et al.
Scientific Reports, 2016, 6 (1), pp.26908. ⟨10.1038/srep26908⟩
Article dans une revue hal-01406943 v1

Native Chemical Ligation Strategy to Overcome Side Reactions during Fmoc-Based Synthesis of C-Terminal Cysteine-Containing Peptides

Dominique Lelièvre , Victor P. Terrier , Agnès F. Delmas , Vincent Aucagne
Organic Letters, 2016, 18 (5), pp.920 - 923. ⟨10.1021/acs.orglett.5b03612⟩
Article dans une revue hal-01407492 v1

Complete 1H, 15N and 13C assignment of trappin-2 and 1H assignment of its two domains, elafin and cementoin

Karine Loth , Soha Abou Ibrahim Alami , Chahrazed Habès , Solène Garrido , Vincent Aucagne et al.
Biomolecular NMR Assignments, 2016, 10 (1), pp.223 - 226. ⟨10.1007/s12104-016-9671-1⟩
Article dans une revue hal-01407495 v1

Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells.

Audrey Gambade , Sami Zreika , Maxime Guéguinou , Igor Chourpa , Gaëlle Fromont et al.
Oncotarget, 2016, 7 (17), pp.23785-23800. ⟨10.18632/oncotarget.8122⟩
Article dans une revue hal-01387061 v1

Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins

Massimiliano Beltramo , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier , Philippe Marceau et al.
Journal of Medicinal Chemistry, 2015, 58 (8), pp.3459-3470. ⟨10.1021/jm5019675⟩
Article dans une revue hal-01170460 v1
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A mechanically interlocked molecular system programmed for the delivery of an anticancer drug

Romain Barat , Thibaut Legigan , I. Tranoy-Opalinski , Brigitte Renoux , Elodie Peraudeau et al.
Chemical Science, 2015, 6 (4), pp.2608-2613. ⟨10.1039/c5sc00648a⟩
Article dans une revue hal-03127729 v1

Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues

Mathieu Galibert , Véronique Piller , Friedrich Piller , Vincent Aucagne , Agnès F. Delmas
Chemical Science, 2015, 6 (6), pp.3617-3623. ⟨10.1039/C5SC00773A⟩
Article dans une revue hal-01178852 v1

The nuclear magnetic resonance solution structure of the synthetic AhPDF1.1b plant defensin evidences the structural feature within the γ-motif

Fanny Meindre , Dominique Lelièvre , Karine Loth , Oriane Mith , Vincent Aucagne et al.
Biochemistry, 2014, 53 (49), pp.7745-54. ⟨10.1021/bi501285k⟩
Article dans une revue hal-01118914 v1

Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates

Isidore E. Decostaire , Dominique Lelièvre , Vincent Aucagne , Agnès F. Delmas
Organic & Biomolecular Chemistry, 2014, 12 (29), pp.5536-5543. ⟨10.1039/c4ob00760c⟩
Article dans une revue hal-01178857 v1
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Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments

Laurent Raibaut , Hélène Adihou , Rémi Desmet , Agnès F. Delmas , Vincent Aucagne et al.
Chemical Science, 2013, 4, pp.4061-4066. ⟨10.1039/c3sc51824h⟩
Article dans une revue hal-00944814 v2

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.

Ibai E Valverde , Fabien Lecaille , Gilles Lalmanach , Vincent Aucagne , Agnès F Delmas
Angewandte Chemie International Edition, 2012, 51 (3), pp.718-22. ⟨10.1002/anie.201107222⟩
Article dans une revue istex hal-00726293 v1
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Initial insights into structure-activity relationships of avian defensins.

Chrystelle Derache , Hervé Meudal , Vincent Aucagne , Kevin J Mark , Martine Cadène et al.
Journal of Biological Chemistry, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩
Article dans une revue hal-00721842 v1

A water soluble Cu-I-NHC for CuAAC ligation of unprotected peptides under open air conditions.

Christelle Gaulier , Audrey Hospital , Bertrand Legeret , Delmas A.F. , Vincent Aucagne et al.
Chemical Communications, 2012, 48, pp.4005-4007
Article dans une revue hal-00711780 v1

Second generation specific-enzyme-activated rotaxane propeptides.

Antony Fernandes , Aurélien Viterisi , Vincent Aucagne , David A Leigh , Sébastien Papot
Chemical Communications, 2012, 48 (15), pp.2083-5. ⟨10.1039/c2cc17458h⟩
Article dans une revue hal-00678757 v1

Towards the simplification of protein synthesis: iterative solid-supported ligations with concomitant purifications.

Vincent Aucagne , Ibai E Valverde , Philippe Marceau , Mathieu Galibert , Nabil Dendane et al.
Angewandte Chemie International Edition, 2012, 51 (45), pp.11320-4. ⟨10.1002/anie.201206428⟩
Article dans une revue istex hal-00748170 v1

Sulfur-containing amide-based [2]rotaxanes and molecular shuttles

Andrea Altieri , Vincent Aucagne , Romen Carrillo , Guy Clarkson , Daniel d'Souza et al.
Chemical Science, 2011, 2 (10), pp.1922. ⟨10.1039/C1SC00335F⟩
Article dans une revue hal-02088663 v1

Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins

Chrystelle Derache , Valérie Labas , Vincent Aucagne , Hervé Meudal , Céline Landon et al.
Antimicrobial Agents and Chemotherapy, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩
Article dans une revue hal-00522326 v1

Click a la carte: robust semi-orthogonal alkyne protecting groups for multiple successive azide/alkyne cycloadditions

Ibai E. Valverde , Agnès F. Delmas , Vincent Aucagne
Tetrahedron, 2009, 65 (36), pp.7597-7602. ⟨10.1016/j.tet.2009.06.093⟩
Article dans une revue istex hal-00525398 v1

Rotaxane-based propeptides: protection and enzymatic release of a bioactive pentapeptide.

Anthony Fernandes , Aurélien Viterisi , Frédéric Coutrot , Stéphanie Potok , David A. Leigh et al.
Angewandte Chemie International Edition, 2009, 48 (35), pp.6443-7. ⟨10.1002/anie.200903215⟩
Article dans une revue hal-00467015 v1

Thermodynamics versus kinetics in hetero-Michael cyclizations: a highly stereoselective approach to access both epimers of a C-D-mannopyranoside

Vincent Aucagne , A. Tatibouët , Patrick Rollin
Tetrahedron Letters, 2008, 49, pp.4750-4753. ⟨10.1016/j.tetlet.2008.05.117⟩
Article dans une revue istex hal-00512453 v1

Preparation of peptide thioesters using Fmoc strategy through hydroxyl side chain anchoring

Dominique Lelièvre , P. Barta , Vincent Aucagne , A.F. Delmas
Tetrahedron Letters, 2008, 49 (25), pp.4016-4019. ⟨10.1016/j.tetlet.2008.04.087⟩
Article dans une revue istex hal-00518141 v1

Study of different copper(I) catalysts for the "click chemistry" approach to carbanucleosides

J. Broggi , N. Joubert , Vincent Aucagne , T. Zevaco , S. Berteina-Raboin et al.
Nucleosides, Nucleotides and Nucleic Acids, 2007, 26, pp.779-783
Article dans une revue hal-00275217 v1

Synergic effect of hydride and proton donors in the Pd(0)-mediated deprotection of Nα-Aloc proline derivatives

Isidore P. Decostaire , Dominique Lelièvre , Vincent Aucagne , Agnès F. Delmas
Tetrahedron Letters, 2007, 48, pp.6523-6526. ⟨10.1016/j.tetlet.2007.07.061⟩
Article dans une revue istex hal-00166600 v1

Catalytic "Active-Metal" template synthesis of [2]rotaxanes, [3]rotaxanes, and molecular shuttles, and some observations on the mechanism of the Cu(I)-catalyzed azide-alkyne 1,3-cycloaddition

Vincent Aucagne , J. Berna , Jd Crowley , Sm Goldup , Kd Haenni et al.
Journal of the American Chemical Society, 2007, 129, pp.11950-11963
Article dans une revue hal-00275210 v1

Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis

Julie Broggi , Nicolas Joubert , Vincent Aucagne , Sabine Berteina-Raboin , S. Diez-Gonzalez et al.
Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (10-12), pp.1391-1394. ⟨10.1080/15257770701534139⟩
Article dans une revue hal-02086003 v1

Chemoselective formation of successive triazole linkages in one pot: "click-click" chemistry

Vincent Aucagne , David A. Leigh
Organic Letters, 2006, 8 (20), pp.4505-4507. ⟨10.1021/ol061657d⟩
Article dans une revue hal-00387909 v1

Rotaxanes of Cyclic Peptides

Vincent Aucagne , David Leigh , Julia Lock , Andrew Thomson
Journal of the American Chemical Society, 2006, 128 (6), pp.1784-1785. ⟨10.1021/ja057206q⟩
Article dans une revue istex hal-02086005 v1

Catalytic “Click” Rotaxanes: A Substoichiometric Metal-Template Pathway to Mechanically Interlocked Architectures

Vincent Aucagne , Kevin Hänni , David Leigh , Paul Lusby , D Barney Walker
Journal of the American Chemical Society, 2006, 128 (7), pp.2186-2187. ⟨10.1021/ja056903f⟩
Article dans une revue istex hal-02086010 v1

Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series

Franck Amblard , Vincent Aucagne , Pierre Guenot , Raymond Schinazi , Luigi Agrofoglio
Bioorganic and Medicinal Chemistry, 2005, 13 (4), pp.1239-1248. ⟨10.1016/j.bmc.2004.11.057⟩
Article dans une revue istex hal-02086014 v1

Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity

Vanessa Escuret , Vincent Aucagne , Nicolas Joubert , David Durantel , Kimberly Rapp et al.
Bioorganic and Medicinal Chemistry, 2005, 13 (21), pp.6015-6024. ⟨10.1016/j.bmc.2005.06.021⟩
Article dans une revue istex hal-02086013 v1

Regioselective Michael-induced cyclisation of γ- and δ-hydroxy vinyl sulfides and vinyl dithiocarbamates

V. Aucagne , C. Lorin , A. Tatibouët , P. Rollin
Tetrahedron Letters, 2005, 46 (25), pp.4349-4352. ⟨10.1016/j.tetlet.2005.04.112⟩
Article dans une revue istex hal-02086017 v1

Highly Efficient AgNO3-Catalyzed Preparation of Substituted Furanopyrimidine Nucleosides [cf. (III)].

Vincent Aucagne , Franck Amblard , Luigi Agrofoglio
ChemInform, 2005, 36 (18), ⟨10.1002/chin.200518181⟩
Article dans une revue istex hal-02086027 v1

Palladium-Catalyzed Synthesis of Uridines on Polystyrene-Based Solid Supports

Vincent Aucagne , Sabine Berteina-Raboin , Pierre Guenot , Luigi Agrofoglio
Journal of Combinatorial Chemistry, 2004, 6 (5), pp.717-723. ⟨10.1021/cc049976o⟩
Article dans une revue hal-02086022 v1

Wittig approach to carbohydrate-derived vinyl sulfides, new substrates for regiocontrolled ring-closure reactions

Vincent Aucagne , Arnaud Tatibouët , Patrick Rollin
Tetrahedron, 2004, 60 (8), pp.1817-1826. ⟨10.1016/j.tet.2003.12.040⟩
Article dans une revue istex hal-02086021 v1

Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′-Diyne seco Analogues through Olefin Metathesis Reactions

Isabelle Gillaizeau , Irene m. Lagoja , Steve p. Nolan , Vincent Aucagne , Jef Rozenski et al.
European Journal of Organic Chemistry, 2003, 2003 (4), pp.666-671. ⟨10.1002/ejoc.200390107⟩
Article dans une revue istex hal-02086029 v1

Sulfenic acids in the carbohydrate field. Synthesis of transient glycosulfenic acids and their addition to unsaturated acceptors.

Vincent Aucagne , Maria Aversa , Anna Barattucci , Paola Bonaccorsi , Placido Giannetto et al.
Journal of Organic Chemistry, 2002, 67 (20), pp.6925-30
Article dans une revue hal-02086034 v1

Synthetic Approaches to C-Glucosinolates

Vincent Aucagne , David Gueyrard , Arnaud Tatibouët , Alain Quinsac , Patrick Rollin
Tetrahedron, 2000, 56 (17), pp.2647-2654. ⟨10.1016/S0040-4020(00)00153-8⟩
Article dans une revue istex hal-02086037 v1

the first synthesis of c-glucotropeolin

V. Aucagne , D. Gueyrard , A. Tatibout , S. Cottaz , H. Driguez et al.
Tetrahedron Letters, 1999, pp.7319-7321
Article dans une revue hal-00309763 v1

Big-Defensin Diversification in Oysters: Implications for Host Defense and Microbiota Management (D. Destoumieux-Garzon INVITED SPEAKER)

Noémie de San Nicolas , A. Jouault , Aromal Asokan , Lhousseine Touqui , K Loth et al.
IMAP 2024 International Meeting on Antimicrobial Peptides, Sep 2024, Londres, United Kingdom
Communication dans un congrès hal-04882843 v1

Big defensins: A Diversified Family of Antimicrobial Peptides Confronting Versatile Microbial Environments (DELPHINE DESTOUMIEUX-GARZON INVITED SPEAKER)

Noémie de San Nicolas , Aromal Asokan , Rafaela da Rosa , Vincent Aucagne , K. Loth et al.
Antimicrobial Peptides. Yesterday, Today, and Tomorrow, Oct 2023, Omaha, Nebraska, USA, United States
Communication dans un congrès hal-04885227 v1

Bacteriocyte-specific Cysteine-Rich (BCR) peptides form a new aphid-specific defensin-like family and are promising regulators of aphid symbiosis

Hugo Terrasson , Karine Loth , Nicolas Parisot , Françoise Paquet , Isabelle Rahioui et al.
Rencontres du Réseau Ecologie des Interactions Durables (REID), May 2023, Poitiers, France
Communication dans un congrès hal-04633283 v1

Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 3

A. Asokan , Noémie de San Nicolas , H. Meudal , K. Loth , Delphine Destoumieux-Garzon et al.
22nd GFPP & 5th BPGM French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France
Communication dans un congrès hal-03976595 v1

Les peptides « Bacteriocyte-specific Cystein-Rich » : une nouvelle famille de défensine. Régulateurs de la symbiose chez les pucerons ?

Hugo Terrasson , Karine Loth , Nicolas Parisot , Françoise Paquet , Isabelle Rahioui et al.
9ème Journées du GDR "MultiFonction des Peptides AntiMicrobiens" (MuFoPAM), Oct 2022, Amboise, France
Communication dans un congrès hal-04633233 v1

Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois.

Hugo Terrasson , Karine Loth , Nicolas Parisot , Françoise Paquet , Isabelle Rahioui et al.
12èmes rencontres du réseau français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France
Communication dans un congrès hal-04771966 v1

Functional DIversification of Big-Defensins and the shaping of oyster microbiota

Noémie de San Nicolas , A. Asokan , R.D. Rosa , S.N. Voisin , Marie Agnès Travers et al.
AMP 2022 7th International Symposium on Antimicrobial Peptides, Nov 2022, Paris, France
Communication dans un congrès hal-03976756 v1

Determination of Binding Affinities with Flow-Induced Dispersion Analysis: The Case of Synthetic Affibodies

Josef Hamacek , Edina Numanovic , Vincent Aucagne
NECTAR, annual meeting, Aug 2021, Lisbon, Portugal
Communication dans un congrès hal-03482197 v1

A chemical toolbox for simplifying chemical protein synthesis

Vincent Aucagne
Congrès annuel de la Société Française de Biochimie et Biologie Moléculaire (SFBBM21), Jul 2021, Paris, France
Communication dans un congrès hal-03563426 v1

Développements méthodologiques pour la synthèse chimique de protéines

Vincent Aucagne
33e colloque Biotechnocentre, Oct 2021, Chaumont-sur-Tharonne, France
Communication dans un congrès hal-03563421 v1

Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation

David Montoir , Mehdi Amoura , Zine El Abidine Ababsa , T.M. Vishwanatha , Expédite Yen-Pon et al.
4. GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France
Communication dans un congrès hal-02892772 v1

Gga-AvBD11, the archetype of a new structural family of defensins

H. Meudal , Nicolas Guyot , K. Loth , G. Jousset , S. Trapp et al.
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès hal-02892790 v1

”Tag and modify” strategy for the Pd-catalyzed Thioglycoconjugation of peptides

D. Montoir , Mehdi Amoura , A. Ababsa Z. E. , M. Vishwanatha T. , E. Yen-Pon et al.
Noncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France
Communication dans un congrès hal-02892775 v1

Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases

G. Lalmanach , M. Wartenberg , M. Galibert , A. Saidi , F. Lecaille et al.
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès hal-02892793 v1

Développement de bras enzymo-labiles pour la synthèse totale de protéines par ligations chimiques sur support solide

S. Abboud , V. Piller , S. Papot , V. Aucagne
32e Colloque Biotechnocentre, Oct 2019, Seillac, France
Communication dans un congrès hal-02893386 v1

Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins

Vincent Aucagne
Institut de Chimie des Substances Naturelles, Mar 2019, Gif-sur-Yvette, France
Communication dans un congrès hal-02974369 v1

An improved synthesis of N-Hnb-Cys peptide crypto-thioesters ‒studies on the epimerization of cysteine during solid-phase reductive amination

S. Abboud , Mehdi Amoura , V. P. Terrier , A. F. Delmas , V. Aucagne
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès hal-02892784 v1

Exploring ancestral traits lost during molecular evolution of Big-Defensins Towards β-defensins (DELPHINE DESTOUMIEUX-GARZON, INVITED SPEAKER)

K Loth , Agnès Vergnes , C Barreto , S Voisin , H. Meudal et al.
Gordon Research Conference "Antimicrobial Peptides", Feb 2019, Barga, Italy
Communication dans un congrès hal-04891216 v1

Synthesis and structural characterization of naturally-occuring disulfide rich antimicrobial peptides Gyros Protein Technologies

A.F. Delmas , Vincent Aucagne
European peptide symposium, Aug 2018, Dublin, Ireland
Communication dans un congrès hal-02919154 v1

Séminaire invité : Développement d’une boîte à outils pour simplifier la synthèse chimique de protéines

Vincent Aucagne
Institut des Biomolécules Max Mousseron, Nov 2018, Montpellier, France
Communication dans un congrès hal-02974372 v1

1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles

Nicolas Guyot , Hervé Meudal , Karine Loth , Guillaume Jousset , Anne Silvestre et al.
5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France
Communication dans un congrès hal-02788993 v1

N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation

Mehdi Amoura , D. Sarraf , L. Nauton , V.P. Terrier , D. Lelièvre et al.
35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland
Communication dans un congrès hal-02892802 v1

Fragment covalent docking (FCD) approach: An innovative in silico tools for the prediction of peptide-protein interaction

Julien Diharce , Mickaël Cueto , Vincent Aucagne , Massimiliano Beltramo , Pascal Bonnet
256th National Meeting and Exposition of the American-Chemical-Society Nanoscience, Nanotechnology and Beyond (ACS), American Chemical Society (ACS). USA., Aug 2018, Boston, United States. pp.2
Communication dans un congrès hal-02734800 v1

Rational design of kisspeptin analogs for the control of reproduction

T.M. Vishwanatha , C. Decourt , V.P. Terrier , V. Robert , M. Galibert et al.
4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium
Communication dans un congrès hal-02892809 v1

Simplifier la synthèse totale de protéines et de mini-protéines riches en pont disulfures

Vincent Aucagne
7e Symposium Francophone de Synthèse Totale (SFST7), Jun 2017, Orsay, France
Communication dans un congrès hal-02892762 v1

Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural products

Vincent Aucagne
Institut Européen de Chimie et Biologie, Apr 2017, Bordeaux, France
Communication dans un congrès hal-02974400 v1

Séminaire invité : Triazolopeptides as proteolysis-resistant, highly potent KISS1R agonists

Vincent Aucagne
Universiteit Gent, May 2017, Gand, Belgium
Communication dans un congrès hal-02974376 v1

A non-chromatographic catch-and-release purification method to simplify the synthesis of cysteine-rich peptides

A. Casas-Mora , M. Galibert , A.F. Delmas , V. Aucagne
20e réunion du Groupe Français des Peptides et des Protéines (GFPP 20), Mar 2017, Arcachon, France
Communication dans un congrès hal-02893392 v1

Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural products

Vincent Aucagne
Vrije Universiteit Brussel, May 2017, Bruxelles, Belgium
Communication dans un congrès hal-02974374 v1

Séminaire invité : Développement d'une boîte à outils pour simplifier la synthèse chimique de protéines

Vincent Aucagne
Laboratoire BioCIS - Biomolécules : Conception, Isolement et Synthèse, Université Paris-Sud, Apr 2017, Châtenay-Malabry, France
Communication dans un congrès hal-02974390 v1

Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins.

Vincent Aucagne
Institut Curie, Jun 2016, Paris, France
Communication dans un congrès hal-02974405 v1

Séminaire invité : A molecular toolbox for exploring new chemical spaces: making simpler the synthesis of biologically- and therapeutically-relevant small proteins and complex peptides

Vincent Aucagne
Sanofi, Sep 2016, Francfort, Germany
Communication dans un congrès hal-02974403 v1

Native Chemical ligation simplifies the access of multidomain antimicrobial peptides: application to the study of big-defensins

A.F. Delmas , V.P. Terrier , R.D. Rosa , A. Bressan , P. Marceau et al.
International symposium on AntiMicrobial Peptides (AMP2016), Jun 2016, Montpellier, France
Communication dans un congrès hal-02892834 v1

New KISS1R agonists with potential for the treatment of reproductive disorder

Massimiliano Beltramo , Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier et al.
11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria
Communication dans un congrès hal-02742248 v1

Design and profiling of new selective KISS1R agonists that stimulate the reproductive system

Massimiliano Beltramo , Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier et al.
8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia
Communication dans un congrès hal-02738894 v1

Avian beta-defensins in the control of bacterial pathogens of chicken digestive tract

Anne-Christine Lalmanach , Chrystelle Derache , Evelyne Esnault , Valérie Labas , V. Aucagne et al.
2. International Symposium on Antimicrobial Peptides. Food Veterinary Medical and Novel Applications, Jun 2009, Saint-Malo, France
Communication dans un congrès hal-02751627 v1

First insights into the structure-activity relationships of avian beta-defensins.

Chrystelle Derache , Hervé Meudal , Vincent Aucagne , Martine Cadène , Agnès Delmas et al.
2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France
Communication dans un congrès hal-02753345 v1

PA1b, un peptide à activité insecticide : relations structure/fonction

P. da Silva , I. Rahioui , C. Laugier , Yvan Rahbé , A. Delmas et al.
XVème Colloque de Physiologie de l'Insecte, 2007, Rennes (France), juillet 2007, France. pp.1-1
Communication dans un congrès hal-00391295 v1

The aphid BCR4 structure and activity uncover a new defensin peptide superfamily

Hugo Terrasson , Karine Loth , Nicolas Parisot , Françoise Paquet , Isabelle Rahioui et al.
XXVII International Congress of Entomology, Aug 2024, Kyoto, Japan
Poster de conférence hal-04702878 v1

The Bacteriocyte-specific Cysteine-Rich (BCR) proteins: a role in the control of aphid symbiosis ?

Hugo Terrasson , Karine Loth , Françoise Paquet , Nicolas Parisot , Isabelle Rahioui et al.
Journée scientifique enjeu « santé globale et bio‐ingénierie » de l'INSA Lyon, Apr 2023, Villeurbanne, France
Poster de conférence hal-04633269 v1

Bacteriocyte specific Cystein Rich peptides, a new defensin like protein family , are promising regulators of aphid symbiosis

Hugo Terrasson , Karine Loth , Nicolas Parisot , Françoise Paquet , Isabelle Rahioui et al.
10th congress of the International Symbiosis Society (ISS) - 3rd International Conference on Holobionts (joint meeting), Jul 2022, Lyon, France
Poster de conférence hal-04771990 v1

Role of big-defensins in the control of oyster microbiota

Noémie de San Nicolas , A Asokan , S Voisin , A Delmas , Vincent Aucagne et al.
8ème journées du GDR MuFoPAM, Oct 2021, Marseille, France.
Poster de conférence hal-04888804 v1

Synthesis of N-Hnb-Cys peptide crypto-thioesters: identification of imadozolidinone and epimerized side products, and development of an optimized protocol

S. Abboud , A.F. Delmas , V. Aucagne
4th GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France
Poster de conférence hal-02893398 v1

Spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals.

Françoise Paquet , K. Loth , C. Arnoult , V. Aucagne , A.F. Delmas
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Poster de conférence hal-02893462 v1

A new structural family for antimicrobial defensins

H. Meudal , K. Loth , G. Jousset , V. Aucagne , Nicolas Guyot et al.
NMR : a tool for biology XIth, Jan 2019, Paris, France
Poster de conférence hal-02919171 v1

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing et al.
21e congrès du Groupe Français des Peptides et des Protéines (GFPP), May 2019, Amboise, France
Poster de conférence hal-02893471 v1
Image document

Design of GPR54 (Kiss1r) crosslinker peptides: new tools to study G protein-coupled receptors (GPCR) localization and function

Vincent Robert , Vishwanatha Thimmalapura Marulappa , Didier Lomet , Caroline Decourt , Laia Miret et al.
SNE, Oct 2019, Tours, France
Poster de conférence hal-03381932 v1

Chemical synthesis and natural abundance NMR: an efficient tandem to unravel 3D structures of unlabeled disulfide rich peptides

Herve Meudal , Françoise Paquet , Laurence Jouvensal , V. Aucagne , A.F. Delmas et al.
21e congrès du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Poster de conférence hal-02919180 v1

N-Hnb-Cys peptide crypto-thioesters: optimized synthetic protocol and second generation device

S. Abboud , Mehdi Amoura , P. Terrier V. , A.F. Delmas , V. Aucagne
Noncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France
Poster de conférence hal-02893409 v1

Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation

T.M. Vishwanatha , D. Montoir , Mehdi Amoura , Z. El Ababsa , E. Yen-Pon et al.
21. Réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Poster de conférence hal-02893488 v1

An improved synthesis of N-Hnb-Cys peptide crypto-thioesters - studies on the epimerization of cysteine during solid-phase reductive amination

S. Abboud , Mehdi Amoura , V.P. Terrier , A.F. Delmas , V. Aucagne
8th Chemical Protein Synthesis meeting (CPS2019), Jun 2019, Berlin, Germany
Poster de conférence hal-02893426 v1

Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation

T.M. Vishwanatha , D. Montoir , Mehdi Amoura , Z. El Ababsa , E. Yen-Pon et al.
26. American Peptide Symposium (APS 2019), Jun 2019, Monterey, Californie, United States
Poster de conférence hal-02893419 v1

A single injection of compound 6 evoked an LH surge and ovulation in 18 week old gilts

R. Cameron , R. Kirkwood , M. Beltramo , V. Aucagne , A. Tilbrook
100th annual meeting of the Endocrine Society (ENDO 2018), Mar 2018, Chicago, Illinois, United States. Endocrine Reviews, 39 (Suppl. 1), pp.281-282, The Endocrine Society’s 100th Annual Meeting and Expo. ⟨10.1093/edrv/39.supp.1⟩
Poster de conférence hal-02894272 v1

Design and optimization of alternative thioester precursors to simplify protein synthesis by native chemical ligation

Mehdi Amoura , V.P. Terrier , A.F. Delmas , V. Aucagne
25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France
Poster de conférence hal-02894273 v1

Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation

Mehdi Amoura , V.P. Terrier , A.F. Delmas , V. Aucagne
35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland
Poster de conférence hal-02894157 v1

Long-lasting increase of gonadotropins by rational design of lipophilic kisspeptin analogs

T.M. Vishwanatha , C. Decourt C , V. Robert , M. Galibert , J.-B. Madinier et al.
2018 International Symposium on Chemical Biology, Jan 2018, Genève, Switzerland
Poster de conférence hal-02894282 v1

The kisspeptin analog C6 triggers ovulation in non-breeding ewe in the absence of progestogen priming

C. Decourt , V. Robert , Didier Lomet , V. Aucagne , Massimiliano Beltramo
9. International Congress of Neuroendocrinology (ICN 2018), Jul 2018, Toronto, Canada
Poster de conférence hal-02894264 v1

Near-infrared emitting lanthanide molecules, macromolecules and nanomaterials: New perspectives of optical biological imaging of living systems

S.V. Eliseeva , V. Aucagne , A.F. Delmas , S. Petoud , I. Gillaizeau
GDR AIm 2018 - 1ères Journées du GDR AİM: "Agents d'imagerie moléculaire", Jun 2018, Orléans, France
Poster de conférence hal-03326661 v1

Development of chemo-enzymatic methodologies for the total synthesis of proteins through solid-supported chemical ligation

S. Abboud , V. Piller , S. Papot , A.F. Delmas , V. Aucagne
31e Colloque Biotechnocentre, Oct 2018, Seillac, France
Poster de conférence hal-02894152 v1

Rational design of kisspeptin analogs for the control of the reproductive system

T.M. Vishwanatha , C. Decourt , V.P. Terrier , V. Robert , J.-B. Madinier et al.
25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France
Poster de conférence hal-02894277 v1

Synthèse chimique et RMN en abondance naturelle : un tandem efficace pour résoudre les structures 3D de peptides/protéines riches en ponts disulfure

Françoise Paquet , H. Meudal , Laurence Jouvensal , K. Loth , V. Aucagne et al.
5es journées annuelles du GDR MuFoPAM, Oct 2018, Paris, France
Poster de conférence hal-02920025 v1

Synthesis of aryl-Thioglycopeptides through chemoselective Pd-catalyzed conjugation

David Montoir , Mehdi Amoura , Zine El Abidine Ababsa , Thimmalapura Marulappa Vishwanatha , Expédite Yen-Pon et al.
35 th European Peptide Symposium, Aug 2018, Dublin, Ireland. 2018
Poster de conférence hal-02734043 v1

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing et al.
35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland
Poster de conférence hal-02894161 v1
Image document

In non-breeding ewes the kisspeptin analog c6 triggers ovulation without progestogen priming

Massimiliano Beltramo , Caroline Decourt , Vincent Robert , Didier Lomet , Vincent Aucagne
9th International Congress of Neuroendocrinology, Jul 2018, Toronto, Canada. , 2018, The 9th International Congress of Neuroendocrinology. Abstract book
Poster de conférence hal-02735160 v1

N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation

Mehdi Amoura , V.P. Terrier , A.F. Delmas , V. Aucagne
4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium
Poster de conférence hal-02894279 v1

Chemical synthesis and natural abundance NMR: An efficient tandem to unravel 3D structures of Disulfide Rich Miniproteins

H. Meudal , Laurence Jouvensal , K. Loth , Françoise Paquet , V. Aucagne et al.
35th European Peptide Symposium, Aug 2018, Dublin, Ireland
Poster de conférence hal-02920483 v1

Development of highly base-labile linkers for the catch-and-release purification of difficult peptides. Application to Avian beta-defensin 2

N. J. Stanley , D. Lelièvre , A.F. Delmas , Vincent Aucagne
20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France.
Poster de conférence hal-02453245 v1

NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity

A. Delmas , K. Loth , Herve Meudal , V. Terrier , R.D. Rosa et al.
NMR: a tool for Biology Xth, Jan 2017, Paris, France
Poster de conférence hal-02453460 v1

Investigation of tachyphylaxis of LH response following repeated injections of the kisspeptin analog C6

Caroline Decourt , Vincent Robert , Didier Lomet , Karine Anger , A. Delmas et al.
Colloque International NeuroFrance 2017, May 2017, Bordeaux, France. 2017, Colloque International NeuroFrance 2017
Poster de conférence hal-01605114 v1

Pattern of LH secretion after repeated treatment with kisspeptin analog C6 reveals differential sensitivity between mice and ewes

C. Decourt , V. Robert , D. Lomet , Vincent Aucagne , G. Anderson et al.
42. Colloque de la société de neuroendocrinologie (SNE 2017), Sep 2017, Dijon, France
Poster de conférence hal-02894288 v1

N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation

Mehdi Amoura , V.P. Terrier , D. Lelièvre , A.F. Delmas , V. Aucagne
25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada
Poster de conférence hal-02894293 v1

Do endogenous kisspeptins and synthetic agonist C6 trigger different intracellular responses?

Vincent Robert , Vincent Aucagne , Caroline Decourt , Massimiliano Beltramo
42e colloque de la société de neuroendocrinologie (SNE 2017), Sep 2017, Dijon, France. 2017, 42ème Colloque de la Société de Neuroendocrinologie
Poster de conférence hal-02733747 v1

Design of a New N-Terminal Linker for the Capture-and-Release Purification of Biologically-Relevant Disulfide-Rich Peptides

A. Casas-Mora , M. Galibert , A.F. Delmas , V. Aucagne
25th American Peptide Symposium (APS 25), Jun 2017, Whistler, Canada
Poster de conférence hal-02894295 v1

NCL-based total synthesis of spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammals

Vincent Aucagne , E. Schmitt , P. Bulet , C. Arnoult.
20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France.
Poster de conférence hal-02453195 v1

Investigation of a kisspeptin analog effects both on synchronization of ovulation and puberty onset in domestic mammals and in rodents

Caroline Decourt , Vincent Robert , Didier Lomet , Vincent Aucagne , Greg Anderson et al.
ReproSciences 2017, Apr 2017, Tours, France. 75 p., 2017, 2èmes Journées Scientifiques du GdR Repro
Poster de conférence hal-01603310 v1

Second generation N-2-hydroxybenzyl-cysteine peptide crypto-thioesters: achieving very fast NCL kinetics at neutral pH

Mehdi Amoura , V. P. Terrier , A.F. Delmas , Vincent Aucagne
20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France
Poster de conférence hal-02453275 v1

NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinity

A.F. Delmas , K. Loth , Herve Meudal , V.P. Terrier , R.D. Rosa et al.
20e congrès annuel du Groupe Français des Peptides et Protéines (GFPP), Mar 2017, Arcachon, France
Poster de conférence hal-02894301 v1

N-2-Hydroxybenzyl-Cysteine Peptides as Efficient Thioester Surrogates for Native Chemical Ligation

Mehdi Amoura , V.P. Terrier , D. Lelièvre , A.F. Delmas , V. Aucagne
7th Chemical Protein Synthesis meeting (CPS 2017), Sep 2017, Haifa, Israel
Poster de conférence hal-02894290 v1

Induction of fertile ovulation and puberty advancement by a new kisspeptin analog

Caroline Decourt , Vincent Robert , Didier Lomet , Karine Anger , M. Galibert et al.
18th International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR)
Poster de conférence hal-01604087 v1

A new selective kisspeptin analog, C6, that advance puberty in mice and stimulate fertile ovulation in ewe

M. Beltramo , V. Robert , D. Lomet , K. Anger , M. Galibert et al.
British Society for Neuroendocrinology Annual Meeting, Sep 2016, Glasgow, United Kingdom
Poster de conférence hal-02453336 v1

A capture-and-release purification strategy to simplify the synthesis of disulfide-rich peptides

A. Casas-Mora , M. Galibert , A.F. Delmas , V. Aucagne
1st PSL Chemical Biology Meeting, Dec 2016, Paris, France.
Poster de conférence hal-02453303 v1

A straightforward strategy for automated Fmoc-based synthesis of peptide “crypto-thioesters”. Application to the total synthesis of biologically-relevant disulfide-rich peptides

V. P. Terrier , H. Adihou , D. Lelièvre , Mehdi Amoura , A.F. Delmas et al.
Journées de Chimie Organique de la Société Chimique de France (JCO2016), Dec 2016, Palaiseau, France.
Poster de conférence hal-02453318 v1

Native Chemical ligation simplifies the access of multi-domain antimicrobial peptides: application to the study of big-defensins

A.F. Delmas , V.P. Terrier , R.D. Rosa , A. Bressan , P. Marceau et al.
34th European Peptide Symposium 2016 (EPS2016), Sep 2016, Leipzig, Germany
Poster de conférence hal-02895296 v1

Laligation native simplifie l’étude de l’activité etdu mécanismed’action des peptides antimicrobiens à multiples domaines :cas des Big défensines d’huître.

Agnes Vergnes , Victor P. Terrier , Bressan Albert , Rafael Diego Rosa , Vincent Aucagne et al.
IIIèmes journées annuelles MuFoPAM « MultiFonction des Peptides AntiMicrobiens », Oct 2016, Tours, France
Poster de conférence hal-02128427 v1

Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins

Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier , P. Marceau et al.
24. Meeting of the American Peptide Society, Jun 2015, Orlando, United States. 2015, 24th Meeting of the American Peptide Society
Poster de conférence hal-02741835 v1

Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotrophins

Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier , P. Marceau et al.
19. Congrès du Groupe Français des Peptides et des Protéines, May 2015, Port-Bail, United States. 2015
Poster de conférence hal-02793091 v1

Induction of synchronized fertile ovulation by a new selective agonist of kisspeptin receptor

Caroline Decourt , Vincent Robert , Didier Lomet , Karine Anger , Mathieu Galibert et al.
1 Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro
Poster de conférence hal-02742326 v1

Development of new kisspeptin analogs to stimulate the reproductive system

Caroline Decourt , Karine Anger , Vincent Robert , Vincent Aucagne , Mathieu Galibert et al.
International Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. , 2014, ICGRIII International Conference on Gonadotropins & Receptors
Poster de conférence hal-02744014 v1
Image document

Design and functional profiling of new KISS1R agonists

Massimiliano Beltramo , V. Aucagne , Vincent Robert , M. Galibert , J.B. Madinier et al.
2. Annual Meeting of the GDR RCPG-PhysioMed, Oct 2013, Illkirch, France. 2013, 2nd Annual Meeting of the GDR RCPG-PhysioMed
Poster de conférence hal-02745908 v1

Improvement of the chemical production of β-defensins including straightforward attribution of disulfide bridges

Mathieu Galibert , Chrystelle Derache , Franck Coste , Hervé Meudal , Anne-Christine Lalmanach et al.
18. Réunion du GFPP, May 2013, Sète, France. 1 p., 2013
Poster de conférence hal-02805308 v1
Image document

La kisspeptine : une nouvelle voie pour maitriser l’ovulation chez les petits ruminants ?

Massimiliano Beltramo , V. Aucagne , R. Vincent , M. Galibert , J.B. Madinier et al.
5. Journées d'Animation Scientifique du département Phase (JAS Phase 2013), Oct 2013, Paris, France. 2013
Poster de conférence hal-02805330 v1

Antibacterial spectrum of avian defensin 2: peculiarities in relationship with structural features

Chrystelle Derache , Emmanuel Kut , Hervé Meudal , Vincent Aucagne , Agnès Delmas et al.
3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications (AMP 2012), Jun 2012, Lille, France. , pp.D-97, 2012
Poster de conférence hal-02807349 v1

Improvement of the chemical production of β-defensins including straighforward attribution of disulfide bridges

M. Galibert , Chrystelle Derache , F. Coste , H. Meudal , Anne-Christine Lalmanach et al.
3. International Symposium on Antimicrobial Peptides: Today knowledge and future applications, Jun 2012, Lille, France. , pp.C-43, 2012, AMP 2012 - Antimicrobial peptide symposium
Poster de conférence hal-02748134 v1

Synthesis and oxidative folding of functional miniproteins containing three disulfide bridges

Chrystelle Derache , Hervé Meudal , Vincent Aucagne , Anne-Christine Lalmanach , Céline Landon et al.
21e Colloque Biotechnocentre, 2008, Seillac, France. 1 p, 2008
Poster de conférence hal-02818274 v1

Solid phase chemical ligation

S. Abboud , A.F. Delmas , V. Aucagne
Brik Asharf, Dawson Philip, Liu Lei. Total Chemical Protein Synthesis, Wiley, 2021, 978-3-527-34660-8
Chapitre d'ouvrage hal-02974365 v1

(9H‐Fluoren‐9‐yl)methanethiol

Vincent Aucagne
Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd, 2011, ⟨10.1002/047084289X.rn01287⟩
Chapitre d'ouvrage hal-02071829 v1