
Vincent AUCAGNE
Présentation
EDUCATION
-
1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology
-
1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans
PROFESSIONAL EXPERIENCES
- 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins
- 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures
- 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities
- 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions
- 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates
RESEARCH INTERESTS
-
Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.
-
Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification
-
Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry
-
Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.
-
Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies
Publications
Publications
Palladium-mediated S-arylation and S-allylation for late-stage peptide functionalisation and protein conjugation37. European Peptide Symposium. 14. International Peptide Symposium, Aug 2024, Florence, Italy. pp.692-P2.010
Communication dans un congrès
hal-05075799
v1
|
|
Big-Defensin Diversification in Oysters: Implications for Host Defense and Microbiota Management (D. Destoumieux-Garzon INVITED SPEAKER)IMAP 2024 International Meeting on Antimicrobial Peptides, Sep 2024, Londres, United Kingdom
Communication dans un congrès
hal-04882843
v1
|
|
Bacteriocyte-specific Cysteine-Rich (BCR) peptides form a new aphid-specific defensin-like family and are promising regulators of aphid symbiosisRencontres du Réseau Ecologie des Interactions Durables (REID), May 2023, Poitiers, France
Communication dans un congrès
hal-04633283
v1
|
|
Big defensins: A Diversified Family of Antimicrobial Peptides Confronting Versatile Microbial Environments (DELPHINE DESTOUMIEUX-GARZON INVITED SPEAKER)Antimicrobial Peptides. Yesterday, Today, and Tomorrow, Oct 2023, Omaha, Nebraska, USA, United States
Communication dans un congrès
hal-04885227
v1
|
|
Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 322nd GFPP & 5th BPGM French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France
Communication dans un congrès
hal-03976595
v1
|
|
Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois.12èmes rencontres du réseau français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France
Communication dans un congrès
hal-04771966
v1
|
|
Les peptides « Bacteriocyte-specific Cystein-Rich » : une nouvelle famille de défensine. Régulateurs de la symbiose chez les pucerons ?9ème Journées du GDR "MultiFonction des Peptides AntiMicrobiens" (MuFoPAM), Oct 2022, Amboise, France
Communication dans un congrès
hal-04633233
v1
|
|
Functional DIversification of Big-Defensins and the shaping of oyster microbiotaAMP 2022 7th International Symposium on Antimicrobial Peptides, Nov 2022, Paris, France
Communication dans un congrès
hal-03976756
v1
|
|
Determination of Binding Affinities with Flow-Induced Dispersion Analysis: The Case of Synthetic AffibodiesNECTAR, annual meeting, Aug 2021, Lisbon, Portugal
Communication dans un congrès
hal-03482197
v1
|
|
A chemical toolbox for simplifying chemical protein synthesisCongrès annuel de la Société Française de Biochimie et Biologie Moléculaire (SFBBM21), Jul 2021, Paris, France
Communication dans un congrès
hal-03563426
v1
|
|
Développements méthodologiques pour la synthèse chimique de protéines33e colloque Biotechnocentre, Oct 2021, Chaumont-sur-Tharonne, France
Communication dans un congrès
hal-03563421
v1
|
|
Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation4. GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France
Communication dans un congrès
hal-02892772
v1
|
|
Développement de bras enzymo-labiles pour la synthèse totale de protéines par ligations chimiques sur support solide32e Colloque Biotechnocentre, Oct 2019, Seillac, France
Communication dans un congrès
hal-02893386
v1
|
|
Gga-AvBD11, the archetype of a new structural family of defensins21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès
hal-02892790
v1
|
|
”Tag and modify” strategy for the Pd-catalyzed Thioglycoconjugation of peptidesNoncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France
Communication dans un congrès
hal-02892775
v1
|
|
Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès
hal-02892793
v1
|
|
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteinsInstitut de Chimie des Substances Naturelles, Mar 2019, Gif-sur-Yvette, France
Communication dans un congrès
hal-02974369
v1
|
|
An improved synthesis of N-Hnb-Cys peptide crypto-thioesters ‒studies on the epimerization of cysteine during solid-phase reductive amination21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès
hal-02892784
v1
|
|
Exploring ancestral traits lost during molecular evolution of Big-Defensins Towards β-defensins (DELPHINE DESTOUMIEUX-GARZON, INVITED SPEAKER)Gordon Research Conference "Antimicrobial Peptides", Feb 2019, Barga, Italy
Communication dans un congrès
hal-04891216
v1
|
|
Séminaire invité : Développement d’une boîte à outils pour simplifier la synthèse chimique de protéinesInstitut des Biomolécules Max Mousseron, Nov 2018, Montpellier, France
Communication dans un congrès
hal-02974372
v1
|
|
Synthesis and structural characterization of naturally-occuring disulfide rich antimicrobial peptides Gyros Protein TechnologiesEuropean peptide symposium, Aug 2018, Dublin, Ireland
Communication dans un congrès
hal-02919154
v1
|
|
N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland
Communication dans un congrès
hal-02892802
v1
|
|
1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France
Communication dans un congrès
hal-02788993
v1
|
|
Fragment covalent docking (FCD) approach: An innovative in silico tools for the prediction of peptide-protein interaction256th National Meeting and Exposition of the American-Chemical-Society Nanoscience, Nanotechnology and Beyond (ACS), American Chemical Society (ACS). USA., Aug 2018, Boston, United States. pp.2
Communication dans un congrès
hal-02734800
v1
|
|
Rational design of kisspeptin analogs for the control of reproduction4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium
Communication dans un congrès
hal-02892809
v1
|
|
Simplifier la synthèse totale de protéines et de mini-protéines riches en pont disulfures7e Symposium Francophone de Synthèse Totale (SFST7), Jun 2017, Orsay, France
Communication dans un congrès
hal-02892762
v1
|
|
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural productsInstitut Européen de Chimie et Biologie, Apr 2017, Bordeaux, France
Communication dans un congrès
hal-02974400
v1
|
|
Séminaire invité : Triazolopeptides as proteolysis-resistant, highly potent KISS1R agonistsUniversiteit Gent, May 2017, Gand, Belgium
Communication dans un congrès
hal-02974376
v1
|
|
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural productsVrije Universiteit Brussel, May 2017, Bruxelles, Belgium
Communication dans un congrès
hal-02974374
v1
|
|
A non-chromatographic catch-and-release purification method to simplify the synthesis of cysteine-rich peptides20e réunion du Groupe Français des Peptides et des Protéines (GFPP 20), Mar 2017, Arcachon, France
Communication dans un congrès
hal-02893392
v1
|
|
Séminaire invité : Développement d'une boîte à outils pour simplifier la synthèse chimique de protéinesLaboratoire BioCIS - Biomolécules : Conception, Isolement et Synthèse, Université Paris-Sud, Apr 2017, Châtenay-Malabry, France
Communication dans un congrès
hal-02974390
v1
|
|
Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins.Institut Curie, Jun 2016, Paris, France
Communication dans un congrès
hal-02974405
v1
|
|
Séminaire invité : A molecular toolbox for exploring new chemical spaces: making simpler the synthesis of biologically- and therapeutically-relevant small proteins and complex peptidesSanofi, Sep 2016, Francfort, Germany
Communication dans un congrès
hal-02974403
v1
|
|
Native Chemical ligation simplifies the access of multidomain antimicrobial peptides: application to the study of big-defensinsInternational symposium on AntiMicrobial Peptides (AMP2016), Jun 2016, Montpellier, France
Communication dans un congrès
hal-02892834
v1
|
|
New KISS1R agonists with potential for the treatment of reproductive disorder11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria
Communication dans un congrès
hal-02742248
v1
|
|
Design and profiling of new selective KISS1R agonists that stimulate the reproductive system8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia
Communication dans un congrès
hal-02738894
v1
|
|
Avian beta-defensins in the control of bacterial pathogens of chicken digestive tract2. International Symposium on Antimicrobial Peptides. Food Veterinary Medical and Novel Applications, Jun 2009, Saint-Malo, France
Communication dans un congrès
hal-02751627
v1
|
|
First insights into the structure-activity relationships of avian beta-defensins.2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France
Communication dans un congrès
hal-02753345
v1
|
|
PA1b, un peptide à activité insecticide : relations structure/fonctionXVème Colloque de Physiologie de l'Insecte, 2007, Rennes (France), juillet 2007, France. pp.1-1
Communication dans un congrès
hal-00391295
v1
|
Solid phase chemical ligationBrik Asharf, Dawson Philip, Liu Lei. Total Chemical Protein Synthesis, Wiley, 2021, 978-3-527-34660-8
Chapitre d'ouvrage
hal-02974365
v1
|
|
(9H‐Fluoren‐9‐yl)methanethiolEncyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd, 2011, ⟨10.1002/047084289X.rn01287⟩
Chapitre d'ouvrage
hal-02071829
v1
|
Peptides dérivés d'une beta-défensine 11 aviaire et leurs utilisationsFrance, N° de brevet: WO 2020/030773 A1. AMV; SA, 3IMo, AIM. 2020
Brevet
hal-02595638
v1
|
|
KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammalsPatent n° : WO2014118318 (A1). 2014, 49 p. + 12 p. annexes
Brevet
hal-02793004
v1
|
|
Composés agonistes du récepteur KISS1R et leur utilisation pour induire l’ovulation chez les mammiféresN° de brevet: FR3001455 (A1). 2013, 34 p. + 10 p. annexes
Brevet
hal-02808772
v1
|
|
A straightforward method to prevent the under-estimated problem of aspartimide formation during chemical ligation-mediated protein synthesis2024
Pré-publication, Document de travail
hal-04797697
v1
|