Vincent AUCAGNE
Présentation
1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery. Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry. Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical SocietiesEDUCATION
PROFESSIONAL EXPERIENCES
RESEARCH INTERESTS
Publications
Publications
Palladium-mediated S-arylation and S-allylation for late-stage peptide functionalisation and protein conjugation37. European Peptide Symposium. 14. International Peptide Symposium, Aug 2024, Florence, Italy. pp.692-P2.010 |
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Big-Defensin Diversification in Oysters: Implications for Host Defense and Microbiota Management (D. Destoumieux-Garzon INVITED SPEAKER)IMAP 2024 International Meeting on Antimicrobial Peptides, Sep 2024, Londres, United Kingdom |
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Big defensins: A Diversified Family of Antimicrobial Peptides Confronting Versatile Microbial Environments (DELPHINE DESTOUMIEUX-GARZON INVITED SPEAKER)Antimicrobial Peptides. Yesterday, Today, and Tomorrow, Oct 2023, Omaha, Nebraska, USA, United States |
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Bacteriocyte-specific Cysteine-Rich (BCR) peptides form a new aphid-specific defensin-like family and are promising regulators of aphid symbiosisRencontres du Réseau Ecologie des Interactions Durables (REID), May 2023, Poitiers, France |
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Les peptides « Bacteriocyte-specific Cystein-Rich » : une nouvelle famille de défensine. Régulateurs de la symbiose chez les pucerons ?9ème Journées du GDR "MultiFonction des Peptides AntiMicrobiens" (MuFoPAM), Oct 2022, Amboise, France |
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Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 322nd GFPP & 5th BPGM French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France |
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Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois.12èmes rencontres du réseau français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France |
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Functional DIversification of Big-Defensins and the shaping of oyster microbiotaAMP 2022 7th International Symposium on Antimicrobial Peptides, Nov 2022, Paris, France |
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Développements méthodologiques pour la synthèse chimique de protéines33e colloque Biotechnocentre, Oct 2021, Chaumont-sur-Tharonne, France |
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Determination of Binding Affinities with Flow-Induced Dispersion Analysis: The Case of Synthetic AffibodiesNECTAR, annual meeting, Aug 2021, Lisbon, Portugal |
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A chemical toolbox for simplifying chemical protein synthesisCongrès annuel de la Société Française de Biochimie et Biologie Moléculaire (SFBBM21), Jul 2021, Paris, France |
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation4. GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France |
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Exploring ancestral traits lost during molecular evolution of Big-Defensins Towards β-defensins (DELPHINE DESTOUMIEUX-GARZON, INVITED SPEAKER)Gordon Research Conference "Antimicrobial Peptides", Feb 2019, Barga, Italy |
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”Tag and modify” strategy for the Pd-catalyzed Thioglycoconjugation of peptidesNoncanonical amino acids (ncAAs): Tools for biological and biophysical investigations, Oct 2019, Paris, France |
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Gga-AvBD11, the archetype of a new structural family of defensins21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France |
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Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France |
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Développement de bras enzymo-labiles pour la synthèse totale de protéines par ligations chimiques sur support solide32e Colloque Biotechnocentre, Oct 2019, Seillac, France |
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Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteinsInstitut de Chimie des Substances Naturelles, Mar 2019, Gif-sur-Yvette, France |
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An improved synthesis of N-Hnb-Cys peptide crypto-thioesters ‒studies on the epimerization of cysteine during solid-phase reductive amination21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France |
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Fragment covalent docking (FCD) approach: An innovative in silico tools for the prediction of peptide-protein interaction256th National Meeting and Exposition of the American-Chemical-Society Nanoscience, Nanotechnology and Beyond (ACS), American Chemical Society (ACS). USA., Aug 2018, Boston, United States. pp.2 |
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Rational design of kisspeptin analogs for the control of reproduction4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium |
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Synthesis and structural characterization of naturally-occuring disulfide rich antimicrobial peptides Gyros Protein TechnologiesEuropean peptide symposium, Aug 2018, Dublin, Ireland |
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Séminaire invité : Développement d’une boîte à outils pour simplifier la synthèse chimique de protéinesInstitut des Biomolécules Max Mousseron, Nov 2018, Montpellier, France |
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N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland |
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1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France |
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Séminaire invité : Développement d'une boîte à outils pour simplifier la synthèse chimique de protéinesLaboratoire BioCIS - Biomolécules : Conception, Isolement et Synthèse, Université Paris-Sud, Apr 2017, Châtenay-Malabry, France |
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Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural productsInstitut Européen de Chimie et Biologie, Apr 2017, Bordeaux, France |
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Séminaire invité : Triazolopeptides as proteolysis-resistant, highly potent KISS1R agonistsUniversiteit Gent, May 2017, Gand, Belgium |
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Simplifier la synthèse totale de protéines et de mini-protéines riches en pont disulfures7e Symposium Francophone de Synthèse Totale (SFST7), Jun 2017, Orsay, France |
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A non-chromatographic catch-and-release purification method to simplify the synthesis of cysteine-rich peptides20e réunion du Groupe Français des Peptides et des Protéines (GFPP 20), Mar 2017, Arcachon, France |
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Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins and constrained peptides natural productsVrije Universiteit Brussel, May 2017, Bruxelles, Belgium |
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Native Chemical ligation simplifies the access of multidomain antimicrobial peptides: application to the study of big-defensinsInternational symposium on AntiMicrobial Peptides (AMP2016), Jun 2016, Montpellier, France |
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Séminaire invité : Development of a molecular toolbox to simplify the chemical synthesis of proteins.Institut Curie, Jun 2016, Paris, France |
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Séminaire invité : A molecular toolbox for exploring new chemical spaces: making simpler the synthesis of biologically- and therapeutically-relevant small proteins and complex peptidesSanofi, Sep 2016, Francfort, Germany |
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New KISS1R agonists with potential for the treatment of reproductive disorder11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria |
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Design and profiling of new selective KISS1R agonists that stimulate the reproductive system8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia |
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First insights into the structure-activity relationships of avian beta-defensins.2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France |
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Avian beta-defensins in the control of bacterial pathogens of chicken digestive tract2. International Symposium on Antimicrobial Peptides. Food Veterinary Medical and Novel Applications, Jun 2009, Saint-Malo, France |
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PA1b, un peptide à activité insecticide : relations structure/fonctionXVème Colloque de Physiologie de l'Insecte, 2007, Rennes (France), juillet 2007, France. pp.1-1 |
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Solid phase chemical ligationBrik Ashraf, Dawson Philip, Liu Lei. Total Chemical Protein Synthesis, Wiley, 2021, 978-3-527-34660-8 |
(9H‐Fluoren‐9‐yl)methanethiolEncyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd, 2011, ⟨10.1002/047084289X.rn01287⟩ |
Peptides dérivés d'une beta-défensine 11 aviaire et leurs utilisationsFrance, N° de brevet: WO 2020/030773 A1. AMV; SA, 3IMo, AIM. 2020 |
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KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammalsPatent n° : WO2014118318 (A1). 2014, 49 p. + 12 p. annexes |
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Composés agonistes du récepteur KISS1R et leur utilisation pour induire l’ovulation chez les mammiféresN° de brevet: FR3001455 (A1). 2013, 34 p. + 10 p. annexes |
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A (poly)Pro tip for preserving native disulfide connectivity during thiol-maleimide bioconjugation of disulfide-rich peptides2025 |
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A straightforward method to prevent the under-estimated problem of aspartimide formation during chemical ligation-mediated protein synthesis2024 |