Wassim El Nemer

45
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Publications

Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease

Steicy Sobrino , Laure Joseph , Elisa Magrin , Anne Chalumeau , Nicolas Hebert et al.

Nature Communications, 2025, 16 (1), pp.3137. ⟨10.1038/s41467-025-58321-4⟩

Article dans une revue hal-05333490v1
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Rapid change in red cell blood group systems after the main Out of Africa of Homo sapiens

Stéphane Mazières , Silvana Condemi , Wassim El Nemer , Jacques Chiaroni

Scientific Reports, 2025, 15 (1), pp.1597. ⟨10.1038/s41598-024-83023-0⟩

Article dans une revue (article de synthèse) hal-04878570v1

A Novel Method for a Precise Identification of Human Erythroblast Subpopulations by Flow Cytometry

Julien Grenier , Auria Godard , Robert Seute , Alexandra Grimaldi , Barbara Peyrard et al.

American Journal of Hematology, 2025, 100 (6), pp.1078-1081. ⟨10.1002/ajh.27668⟩

Article dans une revue hal-05333487v1
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Red Blood Cell Contribution to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Julien Grenier , Wassim El Nemer , Maria de Grandis

International Journal of Molecular Sciences, 2024, 25 (3), pp.1417. ⟨10.3390/ijms25031417⟩

Article dans une revue hal-04477024v1
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Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis

Ralfs Buks , Tracy Dagher , Maria Giustin Rotordam , David Monedero Alonso , Sylvie Cochet et al.

Cells, 2022, 11 (1), pp.49. ⟨10.3390/cells11010049⟩

Article dans une revue hal-03523607v1
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Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression

Panagiotis Antoniou , Giulia Hardouin , Pierre Martinucci , Giacomo Frati , Tristan Felix et al.

Nature Communications, 2022, 13 (1), pp.6618. ⟨10.1038/s41467-022-34493-1⟩

Article dans une revue mnhn-03868573v1
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Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease

Sophie Ramadier , Anne Chalumeau , Tristan Felix , Nadia Othman , Sherazade Aknoun et al.

Molecular Therapy, 2022, 30 (1), pp.145-163. ⟨10.1016/j.ymthe.2021.08.019⟩

Article dans une revue hal-03531070v1
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Characterisation of Asp669Tyr Piezo1 cation channel activity in red blood cells: an unexpected phenotype

Laurent Pérès , David Monedero Alonso , Morgane Nudel , Martin Figeac , Judith Bruge et al.

British Journal of Haematology, 2021, ⟨10.1111/bjh.17467⟩

Article dans une revue hal-03242645v1
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ABCG2 Is Overexpressed on Red Blood Cells in Ph-Negative Myeloproliferative Neoplasms and Potentiates Ruxolitinib-Induced Apoptosis

Ralfs Buks , Mégane Brusson , Sylvie Cochet , Tatiana Galochkina , Bruno Cassinat et al.

International Journal of Molecular Sciences, 2021, 22 (7), pp.3530. ⟨10.3390/ijms22073530⟩

Article dans une revue hal-03531056v1
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Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients

Jue Wang , Laura Hertz , Sandra Ruppenthal , Wassim El Nemer , Philippe Connes et al.

Cells, 2021, 10 (2), pp.456. ⟨10.3390/cells10020456⟩

Article dans une revue hal-03531054v1

Ineffective erythropoiesis in sickle cell disease: new insights and future implications

Wassim El Nemer , Auria Godard , Sara El Hoss

Current Opinion in Hematology, 2021, 28 (3), pp.171-176. ⟨10.1097/MOH.0000000000000642⟩

Article dans une revue hal-03291949v1
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Oxidative stress activates red cell adhesion to laminin in sickle cell disease

Maria Alejandra Lizarralde-Iragorri , Sophie Lefevre , Sylvie Cochet , Sara El Hoss , Valentine Brousse et al.

Haematologica, 2020, 106 (9), pp.haematol.2020.261586. ⟨10.3324/haematol.2020.261586⟩

Article dans une revue hal-02929195v1
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Characterization of red blood cell microcirculatory parameters using a bioimpedance microfluidic device

Tieying Xu , Maria A Lizarralde-Iragorri , Jean Roman , Rasta Ghasemi , Jean-Pierre Lefevre et al.

Scientific Reports, 2020, ⟨10.1038/s41598-020-66693-4⟩

Article dans une revue hal-02872830v1
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Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype

Leslie Weber , Giacomo Frati , Tristan Felix , Giulia Hardouin , Antonio Casini et al.

Science Advances , 2020, 6 (7), pp.eaay9392. ⟨10.1126/sciadv.aay9392⟩

Article dans une revue mnhn-03100446v1

Plasma microparticles of sickle patients during crisis or taking hydroxyurea modify endothelium inflammatory properties

Yohann Garnier , Séverine Ferdinand , Marie Garnier , Kizzy-Clara Cita , Régine Hierso et al.

Blood, 2020, 136 (2), pp.247-256. ⟨10.1182/blood.2020004853⟩

Article dans une revue hal-03091322v1

Dimerization and phosphorylation of Lutheran/basal cell adhesion molecule are critical for its function in cell migration on laminin

Anna Guadall , Sylvie Cochet , Olivier Renaud , Yves Colin , Caroline Le van Kim et al.

Journal of Biological Chemistry, 2019, 294 (41), pp.14911-14921. ⟨10.1074/jbc.RA119.007521⟩

Article dans une revue hal-02416861v1

Reticulocyte and red blood cell deformation triggers specific phosphorylation events

Pedro Moura , Maria Lizarralde Iragorri , Olivier Français , Bruno Le Pioufle , Johannes Dobbe et al.

Blood Advances, 2019, 3 (17), pp.2653-2663. ⟨10.1182/bloodadvances.2019000545⟩

Article dans une revue hal-02289553v1

Band 3 phosphorylation induces irreversible alterations of stored red blood cells

Slim Azouzi , Marc Romana , Nobuto Arashiki , Yuichi Takakuwa , Wassim El Nemer et al.

American Journal of Hematology, 2018, 93 (5), pp.E110 - E112. ⟨10.1002/ajh.25044⟩

Article dans une revue hal-01825593v1

A microfluidic approach to study the effect of mechanical stress on erythrocytes in sickle cell disease

Maria Alejandra Lizarralde Iragorri , Sara El Hoss, , Valentine Brousse , Sophie Lefevre , Michael Dussiot et al.

Lab on a Chip, 2018, 18 (19), pp.2975-2984. ⟨10.1039/C8LC00637G⟩

Article dans une revue hal-01875109v1

Absolute proteome quantification of highly purified populations of circulating reticulocytes and mature erythrocytes

Emilie-Fleur Gautier , Marjorie Leduc , Sylvie Cochet , Karine Bailly , Catherine Lacombe et al.

Blood Advances, 2018, 2 (20), pp.2646-2657. ⟨10.1182/bloodadvances.2018023515⟩

Article dans une revue hal-02365675v1

An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Disease Phenotype

L. Weber , V. Poletti , E. Magrin , C. Antoniani , S. Martin et al.

Molecular Therapy - Methods and Clinical Development, 2018, 10, pp.268-280. ⟨10.1016/j.omtm.2018.07.012⟩

Article dans une revue hal-02880821v1

Impact of hydroxycarbamide and interferon-alpha on red cell adhesion and membrane protein expression in polycythemia vera

Megane Brusson , Maria de Grandis , Sylvie Cochet , Sylvain Bigot , Mickael Marin et al.

Haematologica, 2018, 103 (6), pp.972-981. ⟨10.3324/haematol.2017.182303⟩

Article dans une revue hal-02117996v1

Prognostic factors of disease severity in infants with sickle cell anemia: A comprehensive longitudinal cohort study

Valentine Brousse , Sara El Hoss , Naim Bouazza , Cécile Arnaud , Françoise Bernaudin et al.

American Journal of Hematology, 2018, 93 (11), pp.1411-1419. ⟨10.1002/ajh.25260⟩

Article dans une revue hal-02416879v1
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Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human b-globin locus

Chiara Antoniani , Vasco Meneghini , Annalisa Lattanzi , Tristan Felix , Oriana Romano et al.

Blood, 2018, 131 (17), pp.1960-1973. ⟨10.1182/blood-2017-10-811505⟩

Article dans une revue hal-04325273v1
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Gene Therapy in a Patient with Sickle Cell Disease

Jean-Antoine Ribeil , Salima Hacein-Bey-Abina , Emmanuel Payen , Alessandra Magnani , Michaela Semeraro et al.

New England Journal of Medicine, 2017, 376 (9), pp.848 - 855. ⟨10.1056/NEJMoa1609677⟩

Article dans une revue inserm-01834781v1

Effects of Poloxamer 188 on red blood cell membrane properties in sickle cell anaemia

Barbara Sandor , Mickaël Marin , Claudine Lapouméroulie , Miklos Rabaï , Sophie Lefevre et al.

British Journal of Haematology, 2016, 173 (1), pp.145 - 149. ⟨10.1111/bjh.13937⟩

Article dans une revue hal-01881668v1
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Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria

Julien Duez , John P. Holleran , Papa Alioune Ndour , Sasdekumar Loganathan , Pascal Amireault et al.

Antimicrobial Agents and Chemotherapy, 2015, pp.AAC.05030-14. ⟨10.1128/AAC.05030-14⟩

Article dans une revue hal-01158996v1

A biomimetic microfluidic chip to study the circulation and mechanical retention of red blood cells in the spleen

Julien Picot , Papa Alioune Ndour , Sophie D. Lefevre , Wassim El Nemer , Harvey Tawfik et al.

American Journal of Hematology, 2015, ⟨10.1002/ajh.23941⟩

Article dans une revue hal-01113050v1
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JAK2V617F activates Lu/BCAM-mediated red cell adhesion in polycythemia vera through an EpoR-independent Rap1/Akt pathway.

Maria de Grandis , Marie Cambot , Marie-Paule Wautier , Bruno Cassinat , Christine Chomienne et al.

Blood, 2013, 121 (4), pp.658-65. ⟨10.1182/blood-2012-07-440487⟩

Article dans une revue inserm-00821109v1

Human induced pluripotent stem cells can reach complete terminal maturation In vivo and in vitro evidence in the erythropoietic differentiation model

L. Kobar , F. Yates , N. Oudrhiri , A. Francina , L. Kiger et al.

Haematologica, 2012, 97 (12), pp.1795-1803. ⟨10.3324/haematol.2011.055566⟩

Article dans une revue hal-02920223v1
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Novel role for the Lu/BCAM-spectrin interaction in actin cytoskeleton reorganization

Emmanuel Collec , Marie-Christine Lecomte , Wassim El-Nemer , Yves Colin , Caroline Le van Kim

Biochemical Journal, 2011, 436 (3), pp.699-708. ⟨10.1042/BJ20101717⟩

Article dans une revue hal-00596275v1
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Aggregation of mononuclear and red blood cells through an {alpha}4{beta}1-Lu/basal cell adhesion molecule interaction in sickle cell disease.

Vicky Chaar , Julien Picot , Olivier Renaud , Pablo Bartolucci , Ruben Nzouakou et al.

Haematologica, 2010, 95 (11), pp.1841-8. ⟨10.3324/haematol.2010.026294⟩

Article dans une revue inserm-00821120v1
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Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation.

Pablo Bartolucci , Vicky Chaar , Julien Picot , Dora Bachir , Anoosha Habibi et al.

Blood, 2010, 116 (12), pp.2152-9. ⟨10.1182/blood-2009-12-257444⟩

Article dans une revue inserm-00821117v1
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Ubc9 interacts with Lu/BCAM adhesion glycoproteins and regulates their stability at the membrane of polarized MDCK cells

Emmanuel Collec , Wassim El Nemer , Emilie Gauthier , Pierre Gane , Marie-Christine Lecomte et al.

Biochemical Journal, 2006, 402 (2), pp.311-319. ⟨10.1042/BJ20060861⟩

Article dans une revue hal-00478614v1

Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS.

M. André , Jean-Pierre Le Caer , C. Greco , S. Planchon , W. El Nemer et al.

Proteomics, 2006, 6 (5), pp.1437-1449. ⟨10.1002/pmic.200500180⟩

Article dans une revue istex hal-00904619v1

Le panorama du Paléolithique supérieur vu par les groupes sanguins

Stéphane Mazières , Silvana Condemi , Wassim El Nemer , Chiaroni Jacques

1849e journées de la Société d'Anthropologie de Paris, Jan 2024, Bordeaux, France

Communication dans un congrès hal-04423215v1
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Applying successive mechanical stresses on circulating cells using microfluidic vascular network to assess sickled red blood cells rigidity

Tieying Xu , Maria A. Lizarralde-Iragorri , Olivier Français , Wassim El Nemer , Bruno Le Pioufle

MicroTAS, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Oct 2022, Hangzhou, China

Communication dans un congrès hal-03831982v1
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Different miniaturization systems of electrical biosensing and data acquisition during biological cell transiting within vessel size microchannel

Tieying Xu , Maria Lizarralde Iragorri , Jean Roman , Emile Martincic , Valentine Brousse et al.

25th International Conference on Miniaturized Systems for Chemistry and Life Sciences ( MicroTAS 2021 ), Oct 2021, Palm Springs, United States

Communication dans un congrès hal-03821200v1
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A microfluidic device to statistically determine the distribution of sickle red cell subpopulations using bioimpedance

Tieying Xu , Maria A Lizarralde-Iragorri , Jean Roman , Emile Martincic , Valentine Brousse et al.

Transducers, 2021, on-line, France

Communication dans un congrès hal-03260796v1
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Spherocytes flow behaviours in microrestriction, compared by normal red blood cells of different heat treatment levels

Tieying Xu , Maria Lizarralde Iragorri , Jean Roman , Emile Martincic , Valentine Brousse et al.

MicroTAS 2021, Oct 2021, Palm Springs, United States

Communication dans un congrès hal-03821199v1
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Electrical Sensing of sickled red blood cells subpopulations in microfluidic device

Tieying Xu , Maria A Lizarralde-Iragorri , Jean Roman , Emile Martincic , Valentine Brousse et al.

MicroTAS, Oct 2020, on-line, France

Communication dans un congrès hal-03078878v1
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Electrical Detection of the Mechanical Alteration of Sickling Red Blood Cells within a Microfluidic Capillary Network

Xu Tieying , Maria Lizarralde , Jean Roman , Wassim El Nemer , Bruno Le Pioufle et al.

MicroTAS, Oct 2019, Basel, Switzerland

Communication dans un congrès hal-02387976v1
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Microfluidic device using reusable parylen-pdms packaging for the red blood cell transit time analysis in mechanical constrictions, using impedance measurement

Xu Tieying , Maria Lizarralde , Wassim El Nemer , Bruno Le Pioufle , Olivier Français

MicroTAS, Nov 2018, Kaohsiung, Taiwan

Communication dans un congrès hal-01972640v1
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Monitoring Biological Cell Flow within a Mimicking Capillary Device with Impedance Measurement

Tieying Xu, , Maria Lizarralde, , Wassim El Nemer , Bruno Le Pioufle , Olivier Français

Eurosensors 2017, Sep 2017, Paris, France. pp.3 - 6, ⟨10.3390/proceedings1040517⟩

Communication dans un congrès hal-01592142v1

A microfluidic device to study red blood cell deformability

Wassim El Nemer , Papa Alioune Ndour , Sophie D. Lefevre , Harvey Tawfik , Julien Picot et al.

4th European Conference on Microfluidics, Dec 2014, Limerick, Ireland

Communication dans un congrès hal-01113061v1